chloroquine has been researched along with Trypanosomiasis in 10 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Trypanosomiasis: Infection with protozoa of the genus TRYPANOSOMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, a new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride (1), showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leishmaniasis model." | 3.77 | Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. ( Anklin, C; Bahar, M; Deng, Y; Doskotch, RW; Drew, ME; Gil, RR; He, S; Kinghorn, AD; Navarro-Vázquez, A; Pandharkar, T; Werbovetz, KA; Zhu, X, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bakunov, SA | 3 |
| Bakunova, SM | 3 |
| Wenzler, T | 3 |
| Barszcz, T | 3 |
| Werbovetz, KA | 4 |
| Brun, R | 4 |
| Tidwell, RR | 3 |
| Patrick, DA | 2 |
| Kumar, EV | 1 |
| Ohemeng, KA | 1 |
| Bridges, AS | 1 |
| Jones, SK | 2 |
| Holloway, GA | 1 |
| Charman, WN | 1 |
| Fairlamb, AH | 1 |
| Kaiser, M | 1 |
| Kostewicz, E | 1 |
| Novello, PM | 1 |
| Parisot, JP | 1 |
| Richardson, J | 1 |
| Street, IP | 1 |
| Watson, KG | 1 |
| Baell, JB | 1 |
| Bahar, M | 1 |
| Deng, Y | 1 |
| Zhu, X | 1 |
| He, S | 1 |
| Pandharkar, T | 1 |
| Drew, ME | 1 |
| Navarro-Vázquez, A | 1 |
| Anklin, C | 1 |
| Gil, RR | 1 |
| Doskotch, RW | 1 |
| Kinghorn, AD | 1 |
| Kumar, A | 1 |
| Boykin, DW | 1 |
| Bosc, D | 1 |
| Mouray, E | 1 |
| Cojean, S | 1 |
| Franco, CH | 1 |
| Loiseau, PM | 1 |
| Freitas-Junior, LH | 1 |
| Moraes, CB | 1 |
| Grellier, P | 1 |
| Dubois, J | 1 |
| TELLA, A | 1 |
| von Sonnenburg, F | 1 |
| Prüfer, L | 1 |
| Ogunbanwo, JA | 1 |
| Agbonlahor, DE | 1 |
| Adamu, A | 1 |
| Dalyop, P | 1 |
| Elesha, SO | 1 |
| Fagbenro-Beyioku, AF | 1 |
| Vischer, WA | 1 |
1 review available for chloroquine and Trypanosomiasis
| Article | Year |
|---|---|
[Progress in immunodiagnosis and chemotherapy of protozoan infections].
Topics: Amebiasis; Animals; Antibodies; Babesiosis; Chloroquine; Drug Resistance, Microbial; Giardiasis; Hum | 1983 |
9 other studies available for chloroquine and Trypanosomiasis
| Article | Year |
|---|---|
Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans.
Topics: Animals; Antiprotozoal Agents; Benzofurans; Cations; Disease Models, Animal; Leishmania; Mice; Molec | 2008 |
Structure-activity study of pentamidine analogues as antiprotozoal agents.
Topics: Animals; Antimalarials; Cadaverine; Drug Resistance; Female; Imidazoles; Leishmania donovani; Mice; | 2009 |
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
Topics: Animals; Antiparasitic Agents; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Molecular St | 2009 |
Potent antiprotozoal activity of a novel semi-synthetic berberine derivative.
Topics: Animals; Antiprotozoal Agents; Berberine; Chlorocebus aethiops; Disease Models, Animal; Inhibitory C | 2011 |
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.
Topics: Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania donovani; Mice; Molecula | 2013 |
Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.
Topics: Alkyl and Aryl Transferases; Animals; Antiparasitic Agents; Cell Line; Enzyme Inhibitors; Humans; Im | 2016 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
Effects of anti-protozoal drugs and histopathological studies on trypanosome species.
Topics: Animals; Chloroquine; Female; Humans; Male; Metronidazole; Parasitic Sensitivity Tests; Phenanthrene | 2001 |
Antimicrobial activity of the leprostatic drug 3-(p-chloranilino)-10-(p-chlorphenyl-2,10-dihydro-2-(isopropylimino)-phenazine (G 30'320, B. 663).
Topics: Animals; Antitubercular Agents; Aspergillosis; Candidiasis; Chloroquine; Cricetinae; Disease Models, | 1970 |