chloroquine has been researched along with Trypanosomiasis, African in 21 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This work describes the optimization of the pharmacokinetic properties of a previously published family of triazine lead compounds." | 1.48 | Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives. ( Augustyns, K; Baán, A; Caljon, G; Kiekens, F; Maes, L; Matheeussen, A; Salado, IG; Van der Veken, P; Verdeyen, T, 2018) |
| " rhodesiense in vivo, curing three of four infected mice dosed intraperitoneally at 5 mg/kg x 4 days." | 1.35 | Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. ( Bakunov, SA; Bakunova, SM; Barzcz, T; Brun, R; Chen, H; Jones, SK; Kumar, EV; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (38.10) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodríguez, F | 1 |
| Rozas, I | 1 |
| Kaiser, M | 6 |
| Brun, R | 6 |
| Nguyen, B | 1 |
| Wilson, WD | 1 |
| García, RN | 1 |
| Dardonville, C | 2 |
| Patrick, DA | 2 |
| Bakunov, SA | 2 |
| Bakunova, SM | 2 |
| Kumar, EV | 1 |
| Chen, H | 1 |
| Jones, SK | 1 |
| Wenzler, T | 2 |
| Barzcz, T | 1 |
| Werbovetz, KA | 1 |
| Tidwell, RR | 2 |
| Ferrins, L | 1 |
| Rahmani, R | 1 |
| Sykes, ML | 1 |
| Jones, AJ | 1 |
| Avery, VM | 1 |
| Teston, E | 1 |
| Almohaywi, B | 1 |
| Yin, J | 1 |
| Smith, J | 1 |
| Hyland, C | 1 |
| White, KL | 1 |
| Ryan, E | 1 |
| Campbell, M | 1 |
| Charman, SA | 1 |
| Baell, JB | 1 |
| Ronga, L | 1 |
| Del Favero, M | 1 |
| Cohen, A | 1 |
| Soum, C | 1 |
| Le Pape, P | 1 |
| Savrimoutou, S | 1 |
| Pinaud, N | 1 |
| Mullié, C | 1 |
| Daulouede, S | 1 |
| Vincendeau, P | 1 |
| Farvacques, N | 1 |
| Agnamey, P | 1 |
| Pagniez, F | 1 |
| Hutter, S | 1 |
| Azas, N | 1 |
| Sonnet, P | 1 |
| Guillon, J | 1 |
| Ríos Martínez, CH | 1 |
| Lagartera, L | 1 |
| Sola, I | 1 |
| Castellà, S | 1 |
| Viayna, E | 1 |
| Galdeano, C | 1 |
| Taylor, MC | 1 |
| Gbedema, SY | 1 |
| Pérez, B | 1 |
| Clos, MV | 1 |
| Jones, DC | 1 |
| Fairlamb, AH | 1 |
| Wright, CW | 1 |
| Kelly, JM | 1 |
| Muñoz-Torrero, D | 1 |
| Seebacher, W | 1 |
| Wolkinger, V | 1 |
| Faist, J | 1 |
| Saf, R | 1 |
| Bucar, F | 1 |
| Gröblacher, B | 1 |
| Brantner, A | 1 |
| Merino, V | 1 |
| Kalia, Y | 1 |
| Scapozza, L | 1 |
| Perozzo, R | 1 |
| Weis, R | 1 |
| Karaaslan, C | 1 |
| Göker, H | 1 |
| Previti, S | 1 |
| Ettari, R | 1 |
| Cosconati, S | 1 |
| Amendola, G | 1 |
| Chouchene, K | 1 |
| Wagner, A | 1 |
| Hellmich, UA | 1 |
| Ulrich, K | 1 |
| Krauth-Siegel, RL | 1 |
| Wich, PR | 1 |
| Schmid, I | 1 |
| Schirmeister, T | 1 |
| Gut, J | 1 |
| Rosenthal, PJ | 1 |
| Grasso, S | 1 |
| Zappalà, M | 1 |
| Salado, IG | 1 |
| Baán, A | 1 |
| Verdeyen, T | 1 |
| Matheeussen, A | 1 |
| Caljon, G | 1 |
| Van der Veken, P | 1 |
| Kiekens, F | 1 |
| Maes, L | 1 |
| Augustyns, K | 1 |
| Saccoliti, F | 1 |
| Madia, VN | 1 |
| Tudino, V | 1 |
| De Leo, A | 1 |
| Pescatori, L | 1 |
| Messore, A | 1 |
| De Vita, D | 1 |
| Scipione, L | 1 |
| Mäser, P | 1 |
| Calvet, CM | 1 |
| Jennings, GK | 1 |
| Podust, LM | 1 |
| Costi, R | 1 |
| Di Santo, R | 1 |
| TELLA, A | 1 |
| Poltera, AA | 2 |
| Hochmann, A | 1 |
| Lambert, PH | 1 |
| Coppens, I | 1 |
| Baudhuin, P | 1 |
| Opperdoes, FR | 1 |
| Courtoy, PJ | 1 |
| Buyst, H | 2 |
| Otigbuo, IN | 1 |
| Woo, PT | 1 |
| Geddes, AM | 1 |
| Woodruff, AW | 1 |
21 other studies available for chloroquine and Trypanosomiasis, African
| Article | Year |
|---|---|
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.
Topics: Animals; Antimalarials; Cell Line; DNA; Female; Guanidines; Hemeproteins; Hemin; Imidazolines; Malar | 2008 |
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
Topics: Animals; Antiprotozoal Agents; Benzene; Cell Survival; Leishmania donovani; Mice; Myoblasts; Naphtha | 2009 |
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.
Topics: Anilides; Animals; Humans; Mice; Myoblasts, Skeletal; Rats; Species Specificity; Structure-Activity | 2013 |
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
Topics: Animals; Antiprotozoal Agents; Isoxazoles; Mice; Molecular Structure; Plasmodium falciparum; Prodrug | 2014 |
Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents--part III.
Topics: Animals; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Female; Hep G2 Cells; Hu | 2014 |
Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines.
Topics: Animals; Antiparasitic Agents; Benzamides; Binding Sites; Cell Line; Cell Survival; Disease Models, | 2014 |
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Topics: Aminoquinolines; Animals; Antimalarials; Brain; Cell Line; Dimerization; Hemeproteins; Humans; Malar | 2015 |
Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Azabicyclo Compounds; Disease Models, Animal; D | 2015 |
Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.
Topics: Aniline Compounds; Animals; Antiprotozoal Agents; Benzimidazoles; Cell Line; Humans; Malaria, Falcip | 2016 |
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
Topics: Antimalarials; Carbamates; Cathepsin L; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dip | 2017 |
Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives.
Topics: Animals; Disease Models, Animal; Humans; Mice; Structure-Activity Relationship; Triazines; Tropolone | 2018 |
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Female; Humans; Imidazoles; Inhibitory Con | 2018 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
Chemotherapy, relapses and CNS in experimental African trypanosomiasis.
Topics: Animals; Central Nervous System; Chlorocebus aethiops; Chloroquine; Melarsoprol; Mice; Recurrence; T | 1983 |
Trypanosoma brucei brucei: the response to Melarsoprol in mice with cerebral trypanosomiasis. An immunopathological study.
Topics: Animals; Antigen-Antibody Complex; Arsenicals; Brain; Brain Diseases; Chloroquine; Fluorescent Antib | 1981 |
Role of acidic compartments in Trypanosoma brucei, with special reference to low-density lipoprotein processing.
Topics: Acids; Animals; Chloroquine; Endocytosis; Lipoproteins, LDL; Microscopy, Electron; Rats; Rats, Wista | 1993 |
Sleeping sickness in children.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chloroquine; Humans; Infant; Infant, Newbor | 1977 |
The treatment of T. rhodesiense sleeping sickness, with special reference to its physio-pathological and epidemiological basis.
Topics: Arsenicals; Chloroquine; Humans; Melarsoprol; Proguanil; Suramin; Trypanosomiasis, African; Zambia | 1975 |
The in vitro and in vivo effects of metronidazole and chloroquine on Trypanosoma brucei brucei.
Topics: Animals; Chloroquine; Drug Therapy, Combination; Female; Metronidazole; Mice; Trypanosoma brucei bru | 1988 |
Imported infections. Unexplained fever.
Topics: Africa; Asia; Brucellosis; Chloramphenicol; Chloroquine; Fever; Humans; Leishmaniasis, Visceral; Liv | 1974 |
Current practice in tropical medicine.
Topics: Acute Kidney Injury; Amebiasis; Amebicides; Chloroquine; Cholera; Drug Resistance, Microbial; Hepati | 1969 |