chloroquine has been researched along with Triple Negative Breast Neoplasms in 16 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Triple Negative Breast Neoplasms: Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment." | 5.43 | Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model. ( Bérubé-Lauzière, Y; Bouchard, G; Bujold, R; Geha, S; Paquette, B; Saucier, C; Therriault, H, 2016) |
| "Notwithstanding, Triple Negative Breast Cancer (TNBC) is responsible for 15-20% of breast cancer mortality." | 2.72 | New Insight into Triple-Negative Breast Cancer Therapy: The Potential Roles of Endoplasmic Reticulum Stress and Autophagy Mechanisms. ( Ahmadi, Z; Ashrafizadeh, M; Mohammadinejad, R; Sahebkar, A; Tavakol, S, 2021) |
| "Using as in vitro models the colorectal cancer cell lines HCT116, HT29, and CT26, and as triple-negative breast cancer models the 4T1, M-406, and MDA-MB-231 cell lines, we evaluated the effect of the drugs combination on the viability, apoptosis, clonogenicity, and cellular migratory capacity." | 1.91 | Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers. ( Anselmino, LE; Baglioni, MV; Menacho-Márquez, M; Reynoso, G; Rico, MJ; Rozados, VR; Scharovsky, OG, 2023) |
| " We, therefore, investigated if two PI3K/AKT inhibitors, ipatasertib and taselisib, could induce autophagy in breast cancer models, and whether chloroquine (CQ), a well known autophagy inhibitor, could potentiate ipatasertib and taselisib anti-cancer effect in combination with conventional chemotherapy." | 1.72 | Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models. ( Bruzzese, F; Budillon, A; Caputo, R; Ciardiello, C; Cocco, S; Costantini, S; De Laurentiis, M; Leone, A; Lombardi, R; Piezzo, M; Roca, MS; Sisalli, MJ, 2022) |
| "Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment." | 1.43 | Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model. ( Bérubé-Lauzière, Y; Bouchard, G; Bujold, R; Geha, S; Paquette, B; Saucier, C; Therriault, H, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 9 (56.25) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, H | 1 |
| Bakas, NA | 1 |
| Vamos, M | 1 |
| Chaikuad, A | 1 |
| Limpert, AS | 1 |
| Wimer, CD | 1 |
| Brun, SN | 1 |
| Lambert, LJ | 1 |
| Tautz, L | 1 |
| Celeridad, M | 1 |
| Sheffler, DJ | 1 |
| Knapp, S | 1 |
| Shaw, RJ | 1 |
| Cosford, NDP | 1 |
| Kim, JH | 1 |
| Choi, HS | 1 |
| Lee, DS | 1 |
| Cocco, S | 1 |
| Leone, A | 1 |
| Roca, MS | 1 |
| Lombardi, R | 1 |
| Piezzo, M | 1 |
| Caputo, R | 1 |
| Ciardiello, C | 1 |
| Costantini, S | 1 |
| Bruzzese, F | 1 |
| Sisalli, MJ | 1 |
| Budillon, A | 1 |
| De Laurentiis, M | 1 |
| Wang, X | 1 |
| Yu, J | 1 |
| Liu, X | 1 |
| Luo, D | 1 |
| Li, Y | 2 |
| Song, L | 1 |
| Jiang, X | 2 |
| Yin, X | 1 |
| Wang, Y | 1 |
| Chai, L | 1 |
| Luo, T | 2 |
| Jing, J | 1 |
| Shi, H | 1 |
| Liu, N | 1 |
| Zhang, J | 1 |
| Han, LN | 1 |
| Duan, WQ | 1 |
| Lu, WX | 1 |
| Qiu, H | 1 |
| Lin, Y | 1 |
| Wu, YM | 1 |
| Zhang, H | 2 |
| Yang, FF | 1 |
| Ge, D | 1 |
| Anselmino, LE | 1 |
| Baglioni, MV | 1 |
| Reynoso, G | 1 |
| Rozados, VR | 1 |
| Scharovsky, OG | 1 |
| Rico, MJ | 1 |
| Menacho-Márquez, M | 1 |
| Ashrafizadeh, M | 1 |
| Mohammadinejad, R | 1 |
| Tavakol, S | 1 |
| Ahmadi, Z | 1 |
| Sahebkar, A | 1 |
| El-Ashmawy, NE | 1 |
| Al-Ashmawy, GM | 1 |
| Amr, EA | 1 |
| Khedr, EG | 1 |
| Chen, J | 1 |
| Yang, Y | 1 |
| Russu, WA | 1 |
| Chan, WK | 1 |
| Bousquet, G | 1 |
| El Bouchtaoui, M | 1 |
| Sophie, T | 1 |
| Leboeuf, C | 1 |
| de Bazelaire, C | 1 |
| Ratajczak, P | 1 |
| Giacchetti, S | 1 |
| de Roquancourt, A | 1 |
| Bertheau, P | 1 |
| Verneuil, L | 1 |
| Feugeas, JP | 1 |
| Espié, M | 1 |
| Janin, A | 1 |
| Hu, J | 1 |
| Zhang, Y | 1 |
| Gao, Z | 1 |
| Fu, R | 1 |
| Li, L | 1 |
| Li, J | 1 |
| Cui, H | 1 |
| Gao, N | 1 |
| Maycotte, P | 1 |
| Gearheart, CM | 1 |
| Barnard, R | 1 |
| Aryal, S | 1 |
| Mulcahy Levy, JM | 1 |
| Fosmire, SP | 1 |
| Hansen, RJ | 1 |
| Morgan, MJ | 1 |
| Porter, CC | 1 |
| Gustafson, DL | 1 |
| Thorburn, A | 1 |
| Choi, DS | 2 |
| Blanco, E | 1 |
| Kim, YS | 1 |
| Rodriguez, AA | 1 |
| Zhao, H | 1 |
| Huang, TH | 1 |
| Chen, CL | 1 |
| Jin, G | 1 |
| Landis, MD | 1 |
| Burey, LA | 1 |
| Qian, W | 1 |
| Granados, SM | 1 |
| Dave, B | 1 |
| Wong, HH | 1 |
| Ferrari, M | 1 |
| Wong, ST | 1 |
| Chang, JC | 2 |
| Vogel, RI | 1 |
| Coughlin, K | 1 |
| Scotti, A | 1 |
| Iizuka, Y | 1 |
| Anchoori, R | 1 |
| Roden, RB | 1 |
| Marastoni, M | 1 |
| Bazzaro, M | 1 |
| Liang, DH | 1 |
| Ensor, JE | 1 |
| Kaipparettu, BA | 1 |
| Bass, BL | 1 |
| Bouchard, G | 1 |
| Therriault, H | 1 |
| Geha, S | 1 |
| Bérubé-Lauzière, Y | 1 |
| Bujold, R | 1 |
| Saucier, C | 1 |
| Paquette, B | 1 |
1 review available for chloroquine and Triple Negative Breast Neoplasms
| Article | Year |
|---|---|
New Insight into Triple-Negative Breast Cancer Therapy: The Potential Roles of Endoplasmic Reticulum Stress and Autophagy Mechanisms.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Biomarkers, Tumor; Cell Line, Tumor; Cell Prol | 2021 |
15 other studies available for chloroquine and Triple Negative Breast Neoplasms
| Article | Year |
|---|---|
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Line | 2020 |
Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation.
Topics: Antimalarials; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation | 2021 |
Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models.
Topics: Animals; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Resistance, Neoplasm; Hu | 2022 |
PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Autophagy; Cell Line, Tumor; Chaperonins; Chl | 2022 |
YF343, A Novel Histone Deacetylase Inhibitor, Combined with CQ to Inhibit- Autophagy, Contributes to Increased Apoptosis in Triple- Negative Breast Cancer.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Histone Deacetylase Inhibit | 2023 |
Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chloroquine; Colorectal Neoplasms; Humans; | 2023 |
Inhibition of lovastatin- and docosahexaenoic acid-initiated autophagy in triple negative breast cancer reverted resistance and enhanced cytotoxicity.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Autophagy; Autophagy-Related Protein 7; Ce | 2020 |
The Aryl Hydrocarbon Receptor Undergoes Chaperone-Mediated Autophagy in Triple-Negative Breast Cancer Cells.
Topics: Amino Acid Sequence; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Chaperone-Media | 2021 |
Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer.
Topics: Animals; Antineoplastic Agents; Autophagy; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chlor | 2017 |
ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Calcium-Calmodulin-Dependent Protein Kinase | 2019 |
STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious.
Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein | 2014 |
Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1.
Topics: Animals; Autophagy; Cell Line, Tumor; Chloroquine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytos | 2014 |
Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; | 2015 |
The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Carboplat | 2016 |
Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model.
Topics: Animals; Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Cyclooxygenase 2; Female; Gene Exp | 2016 |