chloroquine has been researched along with Tachycardia, Ventricular in 2 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Atrial and ventricular tachyarrhythmias can be perpetuated by up-regulation of inward rectifier potassium channels." | 1.36 | Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets. ( Berenfeld, O; Calvo, CJ; Chapula, JA; Ferrer-Villada, T; Grzeda, KR; Jalife, J; López-Izquierdo, A; Noujaim, SF; Pandit, S; Ponce-Balbuena, D; Stuckey, JA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaagaard, MD | 1 |
| Matos, LO | 1 |
| Holm, AE | 1 |
| Gomes, LC | 1 |
| Wegener, A | 1 |
| Lima, KO | 1 |
| Vieira, IVM | 1 |
| de Souza, RM | 1 |
| Marinho, CRF | 1 |
| Hviid, L | 1 |
| Vestergaard, LS | 1 |
| Dominguez, H | 1 |
| Biering-Sørensen, T | 1 |
| Silvestre, OM | 1 |
| Brainin, P | 1 |
| Noujaim, SF | 1 |
| Stuckey, JA | 1 |
| Ponce-Balbuena, D | 1 |
| Ferrer-Villada, T | 1 |
| López-Izquierdo, A | 1 |
| Pandit, S | 1 |
| Calvo, CJ | 1 |
| Grzeda, KR | 1 |
| Berenfeld, O | 1 |
| Chapula, JA | 1 |
| Jalife, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Malaria Heart Disease Study: A Novel Pathway to Subclinical Heart Disease[NCT04445103] | 597 participants (Actual) | Observational | 2020-06-21 | Terminated (stopped due to Due to the COVID-19 pandemic it was not possible to complete the study inclusion as originally anticipated.) | |||
| Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study[NCT02932007] | Phase 2 | 40 participants (Anticipated) | Interventional | 2017-03-28 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for chloroquine and Tachycardia, Ventricular
| Article | Year |
|---|---|
Frequency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malaria.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Brazil; Case-Control Studies; Chlor | 2022 |
Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets.
Topics: Animals; Anti-Arrhythmia Agents; Chloroquine; Cytoplasm; Heart; Mice; Models, Molecular; Potassium C | 2010 |