chloroquine has been researched along with Stroke in 3 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine treatment prevented ganglioside dysregulation 3 days post-stroke and partially prevented complex ganglioside depletion 21 days post-stroke." | 5.51 | Chloroquine Restores Ganglioside Homeostasis and Improves Pathological and Behavioral Outcomes Post-stroke in the Rat. ( Caughlin, S; Cechetto, DF; Hepburn, J; Liu, Q; Wang, L; Whitehead, SN; Yeung, KK, 2019) |
| "Chloroquine pretreatment significantly enhanced rats' short-term spatial memory capacity and attenuated the expression of TLR3, IFR3, and IFN-β in the Hippocampus compared to non-treatment control in tGCI rats." | 5.39 | Chloroquine pretreatment inhibits toll-like receptor 3 signaling after stroke. ( Chen, W; Cui, G; Hua, F; Ye, X; Zhao, H; Zhao, Q; Zuo, T, 2013) |
| "Chloroquine treatment prevented ganglioside dysregulation 3 days post-stroke and partially prevented complex ganglioside depletion 21 days post-stroke." | 1.51 | Chloroquine Restores Ganglioside Homeostasis and Improves Pathological and Behavioral Outcomes Post-stroke in the Rat. ( Caughlin, S; Cechetto, DF; Hepburn, J; Liu, Q; Wang, L; Whitehead, SN; Yeung, KK, 2019) |
| "Chloroquine pretreatment significantly enhanced rats' short-term spatial memory capacity and attenuated the expression of TLR3, IFR3, and IFN-β in the Hippocampus compared to non-treatment control in tGCI rats." | 1.39 | Chloroquine pretreatment inhibits toll-like receptor 3 signaling after stroke. ( Chen, W; Cui, G; Hua, F; Ye, X; Zhao, H; Zhao, Q; Zuo, T, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, YY | 1 |
| Zhang, TY | 1 |
| Xue, X | 1 |
| Liu, DM | 1 |
| Zhang, HT | 1 |
| Yuan, LL | 1 |
| Liu, YL | 1 |
| Yang, HL | 1 |
| Sun, SB | 1 |
| Zhang, C | 1 |
| Xu, HS | 1 |
| Wu, CF | 1 |
| Yang, JY | 1 |
| Caughlin, S | 1 |
| Hepburn, J | 1 |
| Liu, Q | 1 |
| Wang, L | 1 |
| Yeung, KK | 1 |
| Cechetto, DF | 1 |
| Whitehead, SN | 1 |
| Cui, G | 1 |
| Ye, X | 1 |
| Zuo, T | 1 |
| Zhao, H | 1 |
| Zhao, Q | 1 |
| Chen, W | 1 |
| Hua, F | 1 |
3 other studies available for chloroquine and Stroke
| Article | Year |
|---|---|
Pseudoginsenoside-F11 attenuates cerebral ischemic injury by alleviating autophagic/lysosomal defects.
Topics: Animals; Apoptosis; Autophagy; Brain; Brain Edema; Brain Ischemia; Chloroquine; Disease Models, Anim | 2017 |
Chloroquine Restores Ganglioside Homeostasis and Improves Pathological and Behavioral Outcomes Post-stroke in the Rat.
Topics: Animals; Behavior, Animal; Cell Survival; Cells, Cultured; Chloroquine; Forelimb; Gangliosides; Home | 2019 |
Chloroquine pretreatment inhibits toll-like receptor 3 signaling after stroke.
Topics: Animals; Chloroquine; Interferon Regulatory Factor-3; Interferon-beta; Male; Memory; Premedication; | 2013 |