chloroquine has been researched along with Splenic Rupture in 4 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Splenic Rupture: Rupture of the SPLEEN due to trauma or disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malaria is a particularly important problem in the southeast Anatolia region of Turkey." | 2.41 | Spontaneous rupture of malarial spleen: two case reports and review of literature. ( Aldemir, M; Büyükbayram, H; Kara , IH; Keles, C; Tacyildiz, IH; Yagmur, Y, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yagmur, Y | 1 |
| Kara , IH | 1 |
| Aldemir, M | 1 |
| Büyükbayram, H | 1 |
| Tacyildiz, IH | 1 |
| Keles, C | 1 |
| Touze, JE | 1 |
| Martet, G | 1 |
| Garnotel, E | 1 |
| Beauté, D | 1 |
| Ducourau, JP | 1 |
| Raphenon, G | 1 |
| Aubry, P | 1 |
| Davis, R | 1 |
| Martelo, OJ | 1 |
| Smoller, M | 1 |
| Saladin, TA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Reproducibility of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers[NCT00367380] | Phase 2 | 18 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Thick blood smear was performed to patients daily on days 7 to 23, and every other day until day 29. Any prove of P. vivax infection was considered positive and confirmed later by real time polymerase chain reaction (rPCR). (NCT00367380)
Timeframe: Twenty eight days
| Intervention | days (Mean) |
|---|---|
| Group 1 | 11 |
| Group 2 | 11 |
| Group 3 | 9 |
1 review available for chloroquine and Splenic Rupture
| Article | Year |
|---|---|
Spontaneous rupture of malarial spleen: two case reports and review of literature.
Topics: Acute Disease; Adult; Antimalarials; Chloroquine; Endemic Diseases; Humans; Incidence; Malaria; Male | 2000 |
3 other studies available for chloroquine and Splenic Rupture
| Article | Year |
|---|---|
[An uncommon complication of chloroquine resistant Plasmodium falciparum malaria: spontaneous splenic rupture].
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparum; Rupture, | 1989 |
Spontaneous rupture of the pathological spleen in malaria.
Topics: Acute Disease; Adult; Chloroquine; Female; Humans; Malaria; Rupture, Spontaneous; Splenectomy; Splen | 1973 |
Malaria in American soldiers.
Topics: Anemia, Hemolytic; Blood Cell Count; Carrier State; Chloroquine; Hematocrit; Hemoglobinometry; Hepat | 1969 |