chloroquine has been researched along with Skin Neoplasms in 31 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Skin Neoplasms: Tumors or cancer of the SKIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia." | 7.79 | Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013) |
| "Chloroquine (CQ) can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible." | 7.79 | PUMA: a puzzle piece in chloroquine's antimelanoma activity. ( Amaravadi, RK, 2013) |
| " We show that a lysosome-independent activity of chloroquine (CQ) prevents degradation of PUMA protein, promotes apoptosis, and reduces the growth of melanoma xenografts in mice." | 7.79 | Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. ( Androphy, EJ; Kaufmann, WK; Lakhter, AJ; Naidu, SR; Sahu, RP; Sun, Y; Travers, JB, 2013) |
| "Melanoma is one of the most common skin infections, has triggered significant morbidity and mortality across the globe." | 5.72 | In silico-prediction of chloroquine as a multi-targeted drug against CDKN2A signaling network associated with cutaneous malignant melanoma. ( Aqeel, M; Awan, L; Bashir, Z; Jan, Z; Kalsoom, S; Muhammad Ali, G; Munir, A; Nadeem, T; Sadia, H; Saeed, A; Ud Din, S, 2022) |
| "Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia." | 3.79 | Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013) |
| "Chloroquine (CQ) can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible." | 3.79 | PUMA: a puzzle piece in chloroquine's antimelanoma activity. ( Amaravadi, RK, 2013) |
| " We show that a lysosome-independent activity of chloroquine (CQ) prevents degradation of PUMA protein, promotes apoptosis, and reduces the growth of melanoma xenografts in mice." | 3.79 | Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. ( Androphy, EJ; Kaufmann, WK; Lakhter, AJ; Naidu, SR; Sahu, RP; Sun, Y; Travers, JB, 2013) |
| " Chloroquine, ergotamine, ethaverine and chronic abuse of non-narcotic analgesic drugs seem to be responsible for the drug-induced cutaneous neuro-phospholipidosis, whereas the same condition was found in two patients with metastatic bronchogenic carcinoma and malignant melanoma." | 3.65 | Tumor- and drug-induced cutaneous neuro-phospholipidosis. ( Orfanos, CE; Runne, U, 1975) |
| " Safety, pharmacokinetics and preliminary efficacy through intratumoural and peritumoural injections of DT01 were evaluated in combination with radiotherapy in a first-in-human phase I trial in patients with unresectable skin metastases from melanoma." | 2.82 | First-in-human phase I study of the DNA-repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma. ( Asselain, B; Avril, MF; Bey, P; Cosset, JM; Devun, F; Dreno, B; Dutreix, M; Dutriaux, C; Grob, JJ; Joly, P; Jouary, T; Kirova, Y; Le Tourneau, C; Lebbé, C; Marty, ME; Maubec, E; Mortier, L; Saiag, P; Sun, JS; Thomas, L, 2016) |
| "Melanoma is one of the most common skin infections, has triggered significant morbidity and mortality across the globe." | 1.72 | In silico-prediction of chloroquine as a multi-targeted drug against CDKN2A signaling network associated with cutaneous malignant melanoma. ( Aqeel, M; Awan, L; Bashir, Z; Jan, Z; Kalsoom, S; Muhammad Ali, G; Munir, A; Nadeem, T; Sadia, H; Saeed, A; Ud Din, S, 2022) |
| "Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy." | 1.40 | Tumor vessel normalization by chloroquine independent of autophagy. ( Agostinis, P; Annaert, W; Boulanger, C; Carmeliet, P; De Bock, K; Dejana, E; Dewerchin, M; Garmyn, M; Georgiadou, M; Gerhardt, H; Ghesquière, B; Kuchnio, A; Maes, H; Moens, S; Nys, K; Peric, A; Quaegebeur, A; Radtke, F; Schoors, S; Vankelecom, H; Vinckier, S; Vion, AC; Wouters, J, 2014) |
| "Early-stage cutaneous squamous cell carcinoma (cSCC) has a favourable prognosis." | 1.39 | Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy. ( Armstrong, JL; Birch-Machin, MA; Ellis, R; Lovat, PE; McKee, C; Wright, TJ, 2013) |
| "The induction of skin cancer in mice of the Swiss (Carshalton) strain, by repeated irradiation with UV-light, was strikingly reduced by the local application of caffeine prior to each exposure." | 1.26 | Inhibition of skin carcinogenesis in vivo by caffeine and other agents. ( Latarjet, R; Zajdela, F, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (51.61) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Kuria, KA | 1 |
| Chepkwony, H | 1 |
| Govaerts, C | 1 |
| Roets, E | 1 |
| Busson, R | 1 |
| De Witte, P | 1 |
| Zupko, I | 1 |
| Hoornaert, G | 1 |
| Quirynen, L | 1 |
| Maes, L | 1 |
| Janssens, L | 1 |
| Hoogmartens, J | 1 |
| Laekeman, G | 1 |
| Jan, Z | 1 |
| Aqeel, M | 1 |
| Munir, A | 1 |
| Saeed, A | 1 |
| Sadia, H | 1 |
| Kalsoom, S | 1 |
| Nadeem, T | 1 |
| Bashir, Z | 1 |
| Awan, L | 1 |
| Ud Din, S | 1 |
| Muhammad Ali, G | 1 |
| Ou, C | 1 |
| Liu, H | 1 |
| Ding, Z | 1 |
| Zhou, L | 1 |
| Motegi, SI | 1 |
| Fujiwara, C | 1 |
| Sekiguchi, A | 1 |
| Yamazaki, S | 1 |
| Yokoyama, Y | 1 |
| Yasuda, M | 1 |
| Ishikawa, O | 1 |
| Wright, TJ | 1 |
| McKee, C | 1 |
| Birch-Machin, MA | 1 |
| Ellis, R | 1 |
| Armstrong, JL | 1 |
| Lovat, PE | 1 |
| Egger, ME | 1 |
| Huang, JS | 1 |
| Yin, W | 1 |
| McMasters, KM | 1 |
| McNally, LR | 1 |
| Amaravadi, RK | 1 |
| Maes, H | 1 |
| Kuchnio, A | 1 |
| Peric, A | 1 |
| Moens, S | 1 |
| Nys, K | 1 |
| De Bock, K | 1 |
| Quaegebeur, A | 1 |
| Schoors, S | 1 |
| Georgiadou, M | 1 |
| Wouters, J | 1 |
| Vinckier, S | 1 |
| Vankelecom, H | 1 |
| Garmyn, M | 1 |
| Vion, AC | 1 |
| Radtke, F | 1 |
| Boulanger, C | 1 |
| Gerhardt, H | 1 |
| Dejana, E | 1 |
| Dewerchin, M | 1 |
| Ghesquière, B | 1 |
| Annaert, W | 1 |
| Agostinis, P | 1 |
| Carmeliet, P | 1 |
| Junco, JJ | 1 |
| Mancha-Ramirez, A | 1 |
| Malik, G | 1 |
| Wei, SJ | 1 |
| Kim, DJ | 1 |
| Liang, H | 1 |
| Slaga, TJ | 1 |
| Le Tourneau, C | 1 |
| Dreno, B | 1 |
| Kirova, Y | 1 |
| Grob, JJ | 1 |
| Jouary, T | 1 |
| Dutriaux, C | 1 |
| Thomas, L | 1 |
| Lebbé, C | 1 |
| Mortier, L | 1 |
| Saiag, P | 1 |
| Avril, MF | 1 |
| Maubec, E | 1 |
| Joly, P | 1 |
| Bey, P | 1 |
| Cosset, JM | 1 |
| Sun, JS | 1 |
| Asselain, B | 1 |
| Devun, F | 1 |
| Marty, ME | 1 |
| Dutreix, M | 1 |
| Ryabaya, OO | 1 |
| Inshakov, AN | 1 |
| Egorova, AV | 1 |
| Emelyanova, MA | 1 |
| Nasedkina, TV | 1 |
| Zasedatelev, AS | 1 |
| Khochenkov, DA | 1 |
| Stepanova, EV | 1 |
| Santos, M | 1 |
| Nogueira, L | 1 |
| Talahri, C | 1 |
| Massone, C | 1 |
| Cerroni, L | 1 |
| Mira, MT | 1 |
| Talhari, S | 1 |
| Lakhter, AJ | 1 |
| Sahu, RP | 1 |
| Sun, Y | 1 |
| Kaufmann, WK | 1 |
| Androphy, EJ | 1 |
| Travers, JB | 1 |
| Naidu, SR | 1 |
| KNOX, JM | 2 |
| FREEMAN, RG | 1 |
| WILLIAMS, DI | 1 |
| ZIEKUR, U | 1 |
| VANBREMEERSCH, F | 1 |
| Pathak, MA | 1 |
| Tokui, T | 1 |
| Kuroiwa, C | 1 |
| Tokui, Y | 1 |
| Sasagawa, K | 1 |
| Kawai, K | 1 |
| Kobayashi, T | 1 |
| Ikeda, T | 1 |
| Komai, T | 1 |
| Passos de Souza, E | 1 |
| Evangelista Segundo, PT | 1 |
| José, FF | 1 |
| Lemaire, D | 1 |
| Santiago, M | 1 |
| Orfanos, CE | 1 |
| Runne, U | 1 |
| Zajdela, F | 1 |
| Latarjet, R | 1 |
| Potekaev, NS | 1 |
| Ivanov, OL | 1 |
| Samgin, MA | 1 |
| Safi, N | 2 |
| Blanquet, P | 2 |
| Boyd, CM | 1 |
| Lieberman, LM | 1 |
| Beierwaltes, WH | 1 |
| Varma, VM | 1 |
| Van Woert, MH | 1 |
| Korb, F | 1 |
| Prasad, KN | 1 |
| Shamberger, RJ | 1 |
| Belisario, JC | 1 |
| Kramer, H | 1 |
| Kocsard, E | 1 |
| Le Coulant, P | 1 |
| Texier, L | 1 |
| Tamisier, JM | 1 |
| Moretti, JL | 1 |
| Van Duuren, BL | 1 |
| Sivak, A | 1 |
| Katz, C | 1 |
| Melchionne, S | 1 |
2 reviews available for chloroquine and Skin Neoplasms
| Article | Year |
|---|---|
ADVANCES IN THE TREATMENT OF SKIN DISEASES.
Topics: Adrenal Cortex Hormones; Chloroquine; Drug Therapy; Electric Stimulation Therapy; Idoxuridine; Lupus | 1964 |
Sunscreens: topical and systemic approaches for protection of human skin against harmful effects of solar radiation.
Topics: 5-Methoxypsoralen; Administration, Oral; Administration, Topical; beta Carotene; Carotenoids; Chloro | 1982 |
2 trials available for chloroquine and Skin Neoplasms
| Article | Year |
|---|---|
First-in-human phase I study of the DNA-repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chemoradiotherapy; Chloroquine; Cholesterol; | 2016 |
Diagnostic efficacy of a radioiodinated chloroquine analog in patients with malignant melanoma.
Topics: Brain Neoplasms; Chloroquine; Clinical Trials as Topic; Eye Neoplasms; Humans; Iodine Radioisotopes; | 1970 |
27 other studies available for chloroquine and Skin Neoplasms
| Article | Year |
|---|---|
The antiplasmodial activity of isolates from Ajuga remota.
Topics: Animals; Antimalarials; Antineoplastic Agents; Chloroquine; Chromatography, Thin Layer; Diterpenes; | 2002 |
In silico-prediction of chloroquine as a multi-targeted drug against CDKN2A signaling network associated with cutaneous malignant melanoma.
Topics: Chloroquine; Cyclin-Dependent Kinase Inhibitor p16; Humans; Melanoma; Melanoma, Cutaneous Malignant; | 2022 |
Chloroquine promotes gefitinib‑induced apoptosis by inhibiting protective autophagy in cutaneous squamous cell carcinoma.
Topics: Antimalarials; Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Line; Cel | 2019 |
Possible contribution of PDGF-BB-induced autophagy in dermatofibrosarcoma protuberans: Autophagy marker Atg5 could be a differential marker between dermatofibrosarcoma protuberans and dermatofibroma.
Topics: Adult; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Autophagy-Related | 2019 |
Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy.
Topics: Analysis of Variance; Antimalarials; Antineoplastic Agents; Autophagy; Carcinoma, Squamous Cell; Chl | 2013 |
Inhibition of autophagy with chloroquine is effective in melanoma.
Topics: Antibiotics, Antineoplastic; Antimalarials; Autophagy; Benzoquinones; Cell Line, Tumor; Chloroquine; | 2013 |
PUMA: a puzzle piece in chloroquine's antimelanoma activity.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Chloroquine; Humans; Melanoma; Proto-Oncogene Pro | 2013 |
Tumor vessel normalization by chloroquine independent of autophagy.
Topics: Angiogenesis Inhibitors; Animals; Autophagy; Autophagy-Related Protein 5; Camptothecin; Cell Line, T | 2014 |
Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; Cell Survival; | 2015 |
Autophagy inhibitors chloroquine and LY294002 enhance temozolomide cytotoxicity on cutaneous melanoma cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Prolife | 2017 |
Hydroa vacciniforme-like lymphoma in a patient from the Brazilian Amazon.
Topics: Acyclovir; Antimalarials; Antineoplastic Agents, Hormonal; Antiviral Agents; Brazil; Child; Chloroqu | 2013 |
Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation.
Topics: Animals; Antimalarials; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Chloroquine | 2013 |
Prophylactic use of chloroquine to prevent skin cancer.
Topics: Chloroquine; Humans; Skin Neoplasms | 1963 |
THE DESTRUCTIVE FORCE OF SUNLIGHT.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Antimalarials; Chloroquine; Dermatology; Humans; Neoplasms; Pho | 1964 |
[THERAPEUTIC EXPERIENCES WITH RESOCHIN AND RESOCHIN-CONTAINING PREPARATIONS IN DERMATOLOGICAL PATIENTS].
Topics: Carcinoma, Squamous Cell; Chloroquine; Drug Eruptions; Drug Therapy; Finger Injuries; Hematoma; Herp | 1964 |
[CUTANEOUS LYMPHOCYTOMAS].
Topics: Chloroquine; Humans; Lymphoma; Methylprednisolone; Neoplasms; Pathology; Pseudolymphoma; Skin Neopla | 1965 |
Contribution of serum lipoproteins as carriers of antitumour agent RS-1541 (palmitoyl rhizoxin) in mice.
Topics: Animals; Antineoplastic Agents; Autoradiography; Carbon Radioisotopes; Chloroquine; Female; In Vitro | 1994 |
Rheumatoid arthritis induced by alpha-interferon therapy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chloroquine; Drug Therapy, Co | 2001 |
Tumor- and drug-induced cutaneous neuro-phospholipidosis.
Topics: Adult; Aged; Analgesics; Axons; Carcinoma, Bronchogenic; Chloroquine; Ergotamine; Female; Humans; Li | 1975 |
Inhibition of skin carcinogenesis in vivo by caffeine and other agents.
Topics: Animals; Caffeine; Cell Line; Chloroquine; DNA; DNA Repair; Female; Malondialdehyde; Mice; Neoplasms | 1978 |
[Principles of modern therapy of primary skin reticulosis].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Chloroquine; Humans; Lymphatic Diseases; Skin Neopla | 1974 |
[Use of labelled molecules in the diagnosis and surveillance of melanomas].
Topics: Chloroquine; Eye Neoplasms; Fluoresceins; Fundus Oculi; Humans; Iodine Radioisotopes; Melanoma; Meth | 1973 |
Regulation of tyrosinase activity in mouse melanoma and skin by changes in melanosomal membrane permeability.
Topics: Animals; Bile Acids and Salts; Catechol Oxidase; Cell Membrane Permeability; Chloroquine; Chlorproma | 1971 |
Inhibitory effect of vitamin A on carcinogenesis.
Topics: Acid Phosphatase; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Benz(a)Anthracenes; B | 1971 |
[Excessive destruction of tissues caused by topical cytotoxic therapy].
Topics: Aged; Benzocycloheptenes; Carcinoma, Basal Cell; Chloroquine; Dermatitis; Facial Neoplasms; Female; | 1970 |
[Use of a new iodated vector (labelled iodoquine) in the diagnosis of nevocarcinoma].
Topics: Adult; Aged; Chloroquine; Female; Humans; Iodine Radioisotopes; Melanoma; Methods; Middle Aged; Neop | 1971 |
Inhibition of tumor induction in two-stage carcinogenesis on mouse skin.
Topics: Aflatoxins; Animals; Antineoplastic Agents; Benz(a)Anthracenes; Chloroquine; Cyclohexanes; Cytarabin | 1969 |