chloroquine has been researched along with Sjogren's Syndrome in 22 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy." | 5.51 | The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model. ( Cheon, EJ; Chung, SH; Lee, HJ; Shin, S; Yoon, SG, 2019) |
| "Hydroxychloroquine (HCQ) is a lysosomotropic agent that is commonly used for treating Sjögren's disease (SjD)." | 1.91 | Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren's disease. ( Afione, SA; Atsumi, T; Chiorini, JA; Ji, Y; Motta, ACF; Nakamura, H; Noguchi, M; Oliveira, FR; Rocha, EM; Tanaka, T; Warner, BM; Zheng, C, 2023) |
| "Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy." | 1.51 | The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model. ( Cheon, EJ; Chung, SH; Lee, HJ; Shin, S; Yoon, SG, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (45.45) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Nakamura, H | 1 |
| Tanaka, T | 1 |
| Ji, Y | 1 |
| Zheng, C | 1 |
| Afione, SA | 1 |
| Warner, BM | 1 |
| Oliveira, FR | 1 |
| Motta, ACF | 1 |
| Rocha, EM | 1 |
| Noguchi, M | 1 |
| Atsumi, T | 1 |
| Chiorini, JA | 1 |
| Lee, HJ | 1 |
| Shin, S | 1 |
| Yoon, SG | 1 |
| Cheon, EJ | 1 |
| Chung, SH | 1 |
| Dos Reis Neto, ET | 1 |
| Kakehasi, AM | 1 |
| de Medeiros Pinheiro, M | 1 |
| Ferreira, GA | 1 |
| Marques, CDL | 1 |
| da Mota, LMH | 1 |
| Dos Santos Paiva, E | 1 |
| Pileggi, GCS | 1 |
| Sato, EI | 1 |
| Reis, APMG | 1 |
| Xavier, RM | 1 |
| Provenza, JR | 1 |
| Fegan, D | 1 |
| Glennon, MJ | 1 |
| Wu, CH | 1 |
| Li, KJ | 1 |
| Yu, CL | 1 |
| Tsai, CY | 1 |
| Hsieh, SC | 1 |
| Pavsic, N | 1 |
| Mraz, J | 1 |
| Strazar, ZD | 1 |
| Gabrijelcic, J | 1 |
| Toplisek, J | 1 |
| Kozelj, M | 1 |
| Prokselj, K | 1 |
| Kobak, S | 1 |
| Deveci, H | 1 |
| Jin, M | 1 |
| Hwang, SM | 1 |
| Davies, AJ | 1 |
| Shin, Y | 1 |
| Bae, JS | 1 |
| Lee, JH | 1 |
| Lee, EB | 1 |
| Song, YW | 1 |
| Park, K | 1 |
| Müller-Höcker, J | 1 |
| Schmid, H | 1 |
| Weiss, M | 1 |
| Dendorfer, U | 1 |
| Braun, GS | 1 |
| HEATON, JM | 1 |
| Milic, V | 1 |
| Ostojic, P | 1 |
| Brahma, AK | 1 |
| Hay, E | 1 |
| Sturgess, DA | 1 |
| Morgan, LH | 1 |
| Peris, P | 1 |
| Font, J | 1 |
| Grau, JM | 1 |
| Martínez de Osaba, MJ | 1 |
| Filella, X | 1 |
| Muñoz-Gómez, J | 1 |
| Vasil'ev, VI | 1 |
| Simonova, MV | 1 |
| Safonova, TN | 1 |
| Mach, ES | 1 |
| Ivanova, AV | 1 |
| Bezuglov, MF | 1 |
| Dugowson, CE | 1 |
| Gilliland, BC | 1 |
| Coles, RS | 1 |
| Henkind, P | 1 |
| Gold, DH | 1 |
| Cziráki, L | 1 |
| Szemere, P | 1 |
| Missmahl, HP | 1 |
| Deseö, E | 1 |
| Chlebowski, J | 1 |
| Propkopczuk, J | 1 |
5 reviews available for chloroquine and Sjogren's Syndrome
| Article | Year |
|---|---|
Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases.
Topics: Antimalarials; Antiphospholipid Syndrome; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; | 2020 |
Management of rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Azathioprine; Chloroquine; Cyc | 1986 |
Ocular manifestations of connective tissue disease.
Topics: Adrenal Cortex Hormones; Child; Chloroquine; Connective Tissue Diseases; Eye Diseases; Female; Giant | 1985 |
Ocular manifestations of rheumatic disorders. Natural and iatrogenic.
Topics: Adrenal Cortex Hormones; Arteritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Chloroquine; Conjunc | 1973 |
[Amyloidosis in chronic rheumatic diseases].
Topics: Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Biopsy; Chloroquine; Chronic Disease; Collagen Dise | 1968 |
1 trial available for chloroquine and Sjogren's Syndrome
| Article | Year |
|---|---|
[Comparative evaluation of the treatment of Sjögren's syndrome with anti-rheumatic preparations].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Chlorambucil; Chloroquine; Clinical Trials as Topic; Dr | 1988 |
16 other studies available for chloroquine and Sjogren's Syndrome
| Article | Year |
|---|---|
Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren's disease.
Topics: Animals; Chloroquine; Hydroxychloroquine; Lysosomal Membrane Proteins; Mice; Retrospective Studies; | 2023 |
The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model.
Topics: Animals; Antirheumatic Agents; Autophagy; Autophagy-Related Protein 5; Biomarkers; Chloroquine; Corn | 2019 |
SLE and dental erosion: a lethal cocktail.
Topics: Adolescent; Anti-Inflammatory Agents; Antirheumatic Agents; Chloroquine; Female; Fever; Fruit; Human | 2014 |
Sjögren's Syndrome Antigen B Acts as an Endogenous Danger Molecule to Induce Interleukin-8 Gene Expression in Polymorphonuclear Neutrophils.
Topics: Ammonium Chloride; Autoantigens; Chloroquine; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; HL- | 2015 |
Shunt reversal due to deterioration of chloroquine-induced cardiomyopathy in a patient with primary Sjögren syndrome.
Topics: Aged; Antimalarials; Cardiac Catheterization; Cardiomyopathies; Chloroquine; Female; Follow-Up Studi | 2016 |
Retinopathy due to antimalarial drugs in patients with connective tissue diseases: are they so innocent? A single center retrospective study.
Topics: Adolescent; Adult; Aged; Antimalarials; Arthritis, Rheumatoid; Chi-Square Distribution; Chloroquine; | 2010 |
Autoantibodies in primary Sjögren's syndrome patients induce internalization of muscarinic type 3 receptors.
Topics: Adult; Aged; Autoantibodies; Calcium; Carbachol; Chloroquine; Clathrin; Down-Regulation; Female; Flu | 2012 |
Chloroquine-induced phospholipidosis of the kidney mimicking Fabry's disease: case report and review of the literature.
Topics: alpha-Galactosidase; Chloroquine; Diagnosis, Differential; Fabry Disease; Female; Humans; Hypertensi | 2003 |
Antimalarials in treatment of Sjogren's syndrome.
Topics: Antimalarials; Blood Group Antigens; Chloroquine; Sjogren's Syndrome | 1959 |
Cerebellar ataxia in a patient with primary Sjögren's syndrome after treatment with chloroquine.
Topics: Aged; Antirheumatic Agents; Cerebellar Ataxia; Chloroquine; Female; Humans; Sjogren's Syndrome | 2008 |
Acquired Brown's syndrome and primary Sjogren's syndrome.
Topics: Adult; Chloroquine; Diplopia; Female; Humans; Ophthalmoplegia; Prednisolone; Sjogren's Syndrome | 1995 |
Calcitriol-mediated hypercalcaemia and increased interleukins in a patient with sarcoid myopathy.
Topics: Antirheumatic Agents; Calcitonin; Calcitriol; Chloroquine; Clodronic Acid; Female; Humans; Hypercalc | 1999 |
[Comparative evaluation of various methods of treatment of patients with Sjögren's disease and syndrome at the hospital-polyclinic stages].
Topics: Ambulatory Care; Chloroquine; Dose-Response Relationship, Drug; Hospitalization; Humans; Prednisolon | 1988 |
[Successful combined immunosuppressive and corticosteroid therapy of Sjögren's disease].
Topics: Adult; Azathioprine; Chloroquine; Female; Humans; Male; Middle Aged; Prednisolone; Sjogren's Syndrom | 1974 |
Treatment of Sjögren's syndrome by delagil.
Topics: Adult; Chloroquine; Female; Humans; Middle Aged; Phosphates; Sjogren's Syndrome | 1968 |
[Trial of Sjögren's syndrome treatment with arechin (Resochin)].
Topics: Chloroquine; Female; Humans; Middle Aged; Sjogren's Syndrome | 1966 |