chloroquine has been researched along with Sickle Cell Trait in 5 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Sickle Cell Trait: The condition of being heterozygous for hemoglobin S.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The hypothesis that chloroquine-induced pruritus (CIP) may be determined by certain genetic factors was tested by investigating the epidemiology of CIP with respect to certain genetic red cell markers namely, haemoglobin genotype, glucose-6-phosphate dehydrogenase (G6PD) deficiency and the ABO blood groups." | 7.71 | Certain red cell genetic factors and prevalence of chloroquine-induced pruritus. ( Ademowo, OG; Sodeinde, O, 2002) |
| "The hypothesis that chloroquine-induced pruritus (CIP) may be determined by certain genetic factors was tested by investigating the epidemiology of CIP with respect to certain genetic red cell markers namely, haemoglobin genotype, glucose-6-phosphate dehydrogenase (G6PD) deficiency and the ABO blood groups." | 3.71 | Certain red cell genetic factors and prevalence of chloroquine-induced pruritus. ( Ademowo, OG; Sodeinde, O, 2002) |
| "Chloroquine resistance has been associated with the emergence of Pfcrt mutant genes." | 1.35 | Chloroquine prophylaxis associated with high prevalence of Plasmodium falciparum pfcrt K76T mutation in people with sickle-cell disease in Benin City, Nigeria. ( Adeolu, A; Agbonlahor, DE; Okodua, M; Omolu, PI; Tatfeng, YM; Tchounga, KS; Yah, CS, 2008) |
| "Intact erythrocytes from subjects with sickle cell anemia bound approximately 71 mumoles of chloroquine per kg with an apparent Kd of 10(-6) M." | 1.27 | Toxic heme in sickle cells: an explanation for death of malaria parasites. ( Chevli, R; Fitch, CD; Orjih, AU, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ademowo, OG | 1 |
| Sodeinde, O | 1 |
| Tatfeng, YM | 1 |
| Agbonlahor, DE | 1 |
| Tchounga, KS | 1 |
| Omolu, PI | 1 |
| Okodua, M | 1 |
| Yah, CS | 1 |
| Adeolu, A | 1 |
| Fowler, VG | 1 |
| Lemnge, M | 1 |
| Irare, SG | 1 |
| Malecela, E | 1 |
| Mhina, J | 1 |
| Mtui, S | 1 |
| Mashaka, M | 1 |
| Mtoi, R | 1 |
| Ogunranti, JO | 1 |
| Aguiyi, JC | 1 |
| Roma, S | 1 |
| Onwukeme, KE | 1 |
| Orjih, AU | 1 |
| Chevli, R | 1 |
| Fitch, CD | 1 |
5 other studies available for chloroquine and Sickle Cell Trait
| Article | Year |
|---|---|
Certain red cell genetic factors and prevalence of chloroquine-induced pruritus.
Topics: Adolescent; Adult; Antimalarials; Biomarkers; Child; Child, Preschool; Chloroquine; Erythrocytes; Fe | 2002 |
Chloroquine prophylaxis associated with high prevalence of Plasmodium falciparum pfcrt K76T mutation in people with sickle-cell disease in Benin City, Nigeria.
Topics: Anemia, Sickle Cell; Animals; Antimalarials; Chemoprevention; Chloroquine; Drug Resistance; Humans; | 2008 |
Efficacy of chloroquine on Plasmodium falciparum transmitted at Amani, eastern Usambara Mountains, north-east Tanzania: an area where malaria has recently become endemic.
Topics: Adolescent; Adult; Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Dose-Response Relatio | 1993 |
Chloroquine-induced pruritus and sickle cell gene trait in Africans: possible pharmacogenetic relationship.
Topics: Adult; Chloroquine; Female; Humans; Male; Middle Aged; Pain Measurement; Pruritus; Sickle Cell Trait | 1992 |
Toxic heme in sickle cells: an explanation for death of malaria parasites.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Animals; Chloroquine; Erythrocytes; Female; Heme; Hemin; Hum | 1985 |