chloroquine has been researched along with Sensitivity and Specificity in 83 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We developed and evaluated a rapid, real-time polymerase chain reaction (PCR) assay to detect Plasmodium falciparum malaria and chloroquine (CQ)-resistance determinants in returned travelers who are febrile." | 7.73 | Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers. ( Farcas, GA; Kain, KC; Soeller, R; Zahirieh, A; Zhong, K, 2006) |
| "Chloroquine retinopathy was defined using previously published criteria." | 5.30 | Detection of color vision defects in chloroquine retinopathy. ( Easterbrook, M; Hovis, JK; Vu, BL, 1999) |
| "We developed and evaluated a rapid, real-time polymerase chain reaction (PCR) assay to detect Plasmodium falciparum malaria and chloroquine (CQ)-resistance determinants in returned travelers who are febrile." | 3.73 | Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers. ( Farcas, GA; Kain, KC; Soeller, R; Zahirieh, A; Zhong, K, 2006) |
| "Sulfadoxine in Homapak was more rapidly absorbed (ka = 0." | 2.72 | Pharmacokinetic interactions between chloroquine, sulfadoxine and pyrimethamine and their bioequivalence in a generic fixed-dose combination in healthy volunteers in Uganda. ( Anokbonggo, WW; Gustafsson, LL; Hellgren, U; Lundblad, MS; Mahindi, M; Ntale, M; Obua, C; Ogwal-Okeng, JW, 2006) |
| " Our results indicated that the serial sampling technique would reduce the number of animals and also compound usage, as well as improve the quality of pharmacokinetic data." | 1.38 | A modified serial blood sampling technique and utility of dried-blood spot technique in estimation of blood concentration: application in mouse pharmacokinetics. ( Kurawattimath, V; Mandlekar, S; Mariappan, TT; Pocha, K; Trivedi, RK, 2012) |
| "Malaria is a major public health problem in Mali and diagnosis is typically based on microscopy." | 1.37 | Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali. ( Beavogui, AH; Diallo, M; Djimdé, A; Doumbo, OK; Doumbo, S; Kayentao, K; Niangaly, A; Ouattara, A; Saye, R; Thera, MA; Traoré, B, 2011) |
| "Parasite recrudescences in 33 consecutive paired episodes during the same pregnancy were identified by msp1 and msp2 genotyping." | 1.35 | Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women. ( Alonso, PL; Aponte, JJ; Bardají, A; Cisteró, P; Mandomando, I; Mayor, A; Menéndez, C; Puyol, L; Sanz, S; Serra-Casas, E; Sigauque, B, 2009) |
| " One of the difficulties in this setup is the poor bioavailability of oligonucleotides, as the most frequently used transfection agents are unsuitable for in vivo use." | 1.33 | Induction of splice correction by cell-penetrating peptide nucleic acids. ( El-Andaloussi, S; Johansson, HJ; Langel, U; Lundberg, P, 2006) |
| "Chloroquine is known to inhibit platelet activation by various mechanisms including arachidonic acid liberation from membrane phospholipids." | 1.30 | Chloroquine minimizes sampling artefacts for radioimmunological determination of thromboxane B2 in plasma. ( al-Malicky, B; Kritz, H; Oguogho, A; Sinzinger, H, 1997) |
| "Chloroquine retinopathy was defined using previously published criteria." | 1.30 | Detection of color vision defects in chloroquine retinopathy. ( Easterbrook, M; Hovis, JK; Vu, BL, 1999) |
| "Chloroquine resistance was detected in 38% of the subjects by thick blood smear and in 45% by the QBC test." | 1.28 | Rapid in vivo detection of chloroquine resistance by the Quantitative Buffy Coat Malaria Diagnosis System. ( Busangu, I; Garin, B; Perrone, J; Peyron, F; Salun, JJ; Vigier, JP, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.41) | 18.7374 |
| 1990's | 17 (20.48) | 18.2507 |
| 2000's | 46 (55.42) | 29.6817 |
| 2010's | 16 (19.28) | 24.3611 |
| 2020's | 2 (2.41) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, JD | 2 |
| Dennull, RA | 1 |
| Gerena, L | 1 |
| Lopez-Sanchez, M | 1 |
| Roncal, NE | 1 |
| Waters, NC | 1 |
| Druilhe, P | 2 |
| Brasseur, P | 2 |
| Blanc, C | 1 |
| Makler, M | 1 |
| Blackie, MA | 1 |
| Beagley, P | 1 |
| Croft, SL | 1 |
| Kendrick, H | 1 |
| Moss, JR | 1 |
| Chibale, K | 1 |
| Desroches, J | 1 |
| Kieffer, C | 1 |
| Primas, N | 1 |
| Hutter, S | 1 |
| Gellis, A | 1 |
| El-Kashef, H | 1 |
| Rathelot, P | 1 |
| Verhaeghe, P | 1 |
| Azas, N | 2 |
| Vanelle, P | 1 |
| Kaagaard, MD | 1 |
| Matos, LO | 1 |
| Holm, AE | 1 |
| Gomes, LC | 1 |
| Wegener, A | 1 |
| Lima, KO | 1 |
| Vieira, IVM | 1 |
| de Souza, RM | 1 |
| Marinho, CRF | 1 |
| Hviid, L | 1 |
| Vestergaard, LS | 1 |
| Dominguez, H | 1 |
| Biering-Sørensen, T | 1 |
| Silvestre, OM | 1 |
| Brainin, P | 1 |
| Pukáncsik, M | 1 |
| Molnár, P | 1 |
| Orbán, Á | 1 |
| Butykai, Á | 1 |
| Marton, L | 1 |
| Kézsmárki, I | 1 |
| Vértessy, BG | 1 |
| Kamil, M | 1 |
| Abraham, A | 1 |
| Aly, ASI | 1 |
| Luo, X | 1 |
| Peng, Y | 1 |
| Ge, W | 1 |
| Elliott, P | 1 |
| G'Sell, M | 1 |
| Snyder, LM | 1 |
| Ross, SE | 1 |
| Ventura, V | 1 |
| Chahar, M | 1 |
| Anvikar, A | 1 |
| Dixit, R | 1 |
| Valecha, N | 2 |
| Rochford, R | 1 |
| Ohrt, C | 1 |
| Baresel, PC | 1 |
| Campo, B | 1 |
| Sampath, A | 1 |
| Magill, AJ | 1 |
| Tekwani, BL | 1 |
| Walker, LA | 1 |
| Tsang, AC | 1 |
| Ahmadi Pirshahid, S | 1 |
| Virgili, G | 1 |
| Gottlieb, CC | 1 |
| Hamilton, J | 1 |
| Coupland, SG | 1 |
| Byeon, H | 1 |
| Ha, YR | 1 |
| Lee, SJ | 1 |
| Cheruiyot, AC | 1 |
| Auschwitz, JM | 1 |
| Lee, PJ | 1 |
| Yeda, RA | 1 |
| Okello, CO | 1 |
| Leed, SE | 1 |
| Talwar, M | 1 |
| Murthy, T | 1 |
| Gaona, HW | 1 |
| Hickman, MR | 1 |
| Akala, HM | 1 |
| Kamau, E | 1 |
| dos Santos Magalhães, IR | 1 |
| Sueli Bonato, P | 1 |
| Mayor, A | 2 |
| Serra-Casas, E | 1 |
| Bardají, A | 1 |
| Sanz, S | 1 |
| Puyol, L | 1 |
| Cisteró, P | 1 |
| Sigauque, B | 1 |
| Mandomando, I | 1 |
| Aponte, JJ | 1 |
| Alonso, PL | 1 |
| Menéndez, C | 1 |
| Juliano, JJ | 2 |
| Randrianarivelojosia, M | 1 |
| Ramarosandratana, B | 1 |
| Ariey, F | 1 |
| Mwapasa, V | 3 |
| Meshnick, SR | 3 |
| Wang, Y | 1 |
| Mangipudi, SS | 1 |
| Canine, BF | 1 |
| Hatefi, A | 1 |
| Moneriz, C | 1 |
| Marín-García, P | 1 |
| Bautista, JM | 1 |
| Diez, A | 1 |
| Puyet, A | 1 |
| Gan, LS | 1 |
| Loh, JP | 1 |
| Frita, R | 1 |
| Rebelo, M | 1 |
| Pamplona, A | 1 |
| Vigario, AM | 1 |
| Mota, MM | 1 |
| Grobusch, MP | 2 |
| Hänscheid, T | 1 |
| Khalil, IF | 1 |
| Alifrangis, M | 1 |
| Recke, C | 1 |
| Hoegberg, LC | 1 |
| Ronn, A | 1 |
| Bygbjerg, IC | 1 |
| Koch, C | 1 |
| Wongwan, S | 1 |
| Scriba, GK | 1 |
| Kurawattimath, V | 1 |
| Pocha, K | 1 |
| Mariappan, TT | 1 |
| Trivedi, RK | 1 |
| Mandlekar, S | 1 |
| Ouattara, A | 1 |
| Doumbo, S | 1 |
| Saye, R | 1 |
| Beavogui, AH | 1 |
| Traoré, B | 1 |
| Djimdé, A | 1 |
| Niangaly, A | 1 |
| Kayentao, K | 1 |
| Diallo, M | 1 |
| Doumbo, OK | 1 |
| Thera, MA | 2 |
| Sabbatani, S | 1 |
| Fiorino, S | 1 |
| Manfredi, R | 1 |
| Schlagenhauf, P | 1 |
| Petersen, E | 1 |
| Kaushal, DC | 1 |
| Kaushal, NA | 1 |
| Jelinek, T | 2 |
| Aida, AO | 1 |
| Peyerl-Hoffmann, G | 1 |
| Jordan, S | 2 |
| Heuschkel, C | 1 |
| el Valy, AO | 1 |
| von Sonnenburg, F | 1 |
| Christophel, EM | 2 |
| Derleth, DP | 1 |
| Singh, N | 2 |
| Nagpal, AC | 1 |
| Mishra, SS | 1 |
| Varma, HS | 1 |
| Subbarao, SK | 1 |
| Berens, N | 1 |
| Schwoebel, B | 1 |
| Vanisaveth, V | 1 |
| Phetsouvanh, R | 1 |
| Phompida, S | 1 |
| Yin, F | 1 |
| Guo, M | 2 |
| Yao, S | 2 |
| Vessière, A | 1 |
| Berry, A | 2 |
| Fabre, R | 2 |
| Benoit-Vical, F | 2 |
| Magnaval, JF | 2 |
| Wilson, PE | 1 |
| Kazadi, W | 1 |
| Kamwendo, DD | 1 |
| Purfield, A | 1 |
| Wang, H | 1 |
| Ciobanu, L | 1 |
| Webb, A | 1 |
| Samanidou, VF | 1 |
| Evaggelopoulou, EN | 1 |
| Papadoyannis, IN | 1 |
| Mishra, AK | 1 |
| Shukla, MM | 1 |
| Chand, SK | 1 |
| Bharti, PK | 1 |
| Senescau, A | 1 |
| Landt, O | 1 |
| Lelièvre, J | 1 |
| Cassaing, S | 1 |
| Mishra, S | 1 |
| Raj, DK | 1 |
| Hazra, RK | 1 |
| Dash, AP | 1 |
| Supakar, PC | 1 |
| Farcas, GA | 1 |
| Soeller, R | 1 |
| Zhong, K | 1 |
| Zahirieh, A | 1 |
| Kain, KC | 1 |
| Deng, H | 1 |
| Liu, H | 1 |
| Krogstad, FM | 1 |
| Krogstad, DJ | 1 |
| Kosaisavee, V | 1 |
| Suwanarusk, R | 1 |
| Nosten, F | 1 |
| Kyle, DE | 1 |
| Barrends, M | 1 |
| Jones, J | 1 |
| Price, R | 1 |
| Russell, B | 1 |
| Lek-Uthai, U | 1 |
| Unger, JP | 1 |
| d'Alessandro, U | 2 |
| De Paepe, P | 1 |
| Green, A | 1 |
| El-Andaloussi, S | 1 |
| Johansson, HJ | 1 |
| Lundberg, P | 1 |
| Langel, U | 1 |
| Obua, C | 1 |
| Ntale, M | 1 |
| Lundblad, MS | 1 |
| Mahindi, M | 1 |
| Gustafsson, LL | 2 |
| Ogwal-Okeng, JW | 1 |
| Anokbonggo, WW | 1 |
| Hellgren, U | 1 |
| Kaddouri, H | 1 |
| Nakache, S | 1 |
| Houzé, S | 1 |
| Mentré, F | 1 |
| Le Bras, J | 1 |
| Chea, A | 1 |
| Hout, S | 1 |
| Long, C | 1 |
| Marcourt, L | 1 |
| Faure, R | 1 |
| Elias, R | 1 |
| Ibrahim, H | 1 |
| Bouajila, J | 1 |
| Siri, N | 1 |
| Rozing, G | 1 |
| Nepveu, F | 1 |
| Couderc, F | 1 |
| Singhal, P | 1 |
| Gaur, A | 1 |
| Behl, V | 1 |
| Gautam, A | 1 |
| Varshney, B | 1 |
| Paliwal, J | 1 |
| Batra, V | 1 |
| Ndyomugyenyi, R | 1 |
| Magnussen, P | 2 |
| Clarke, S | 1 |
| Lee, E | 1 |
| Hart, K | 1 |
| Burgess, G | 1 |
| Halverson, GR | 1 |
| Reid, ME | 1 |
| Huang, Y | 1 |
| Pan, W | 1 |
| Scotti da Silva-Colombeli, A | 1 |
| Falkenberg, M | 1 |
| Kwiek, JJ | 1 |
| Cappell, K | 1 |
| Pfeiffer, K | 1 |
| Some, F | 1 |
| Müller, O | 1 |
| Sie, A | 1 |
| Kouyaté, B | 1 |
| Haefeli, WE | 1 |
| Zoungrana, A | 1 |
| Tomson, G | 1 |
| Sauerborn, R | 1 |
| Imada, M | 1 |
| Simons, FE | 1 |
| Jay, FT | 1 |
| Hayglass, KT | 1 |
| Taylor, RB | 1 |
| Reid, RG | 1 |
| Croes, K | 1 |
| McCarthy, PT | 1 |
| Flanagan, RJ | 1 |
| Kotecka, BM | 1 |
| Rieckmann, KH | 1 |
| Hovorka, R | 1 |
| Powrie, JK | 1 |
| Smith, GD | 1 |
| Sönksen, PH | 1 |
| Carson, ER | 1 |
| Jones, RH | 1 |
| Pandya, AP | 1 |
| Lambert, WE | 1 |
| Van Bocxlaer, JF | 1 |
| De Leenheer, AP | 1 |
| Oguogho, A | 1 |
| al-Malicky, B | 1 |
| Kritz, H | 1 |
| Sinzinger, H | 1 |
| Mharakurwa, S | 1 |
| Shiff, CJ | 1 |
| Ducharme, J | 1 |
| Farinotti, R | 1 |
| Hawley, SR | 1 |
| Bray, PG | 1 |
| Mungthin, M | 1 |
| Atkinson, JD | 1 |
| O'Neill, PM | 1 |
| Ward, SA | 1 |
| Adagu, IS | 2 |
| Kremsner, PG | 1 |
| Warhurst, DC | 3 |
| Vu, BL | 1 |
| Easterbrook, M | 2 |
| Hovis, JK | 1 |
| Duraisingh, MT | 1 |
| Jones, P | 1 |
| Sambou, I | 1 |
| von Seidlein, L | 1 |
| Pinder, M | 1 |
| Carrasquilla, G | 1 |
| Banguero, M | 1 |
| Sanchez, P | 1 |
| Carvajal, F | 1 |
| Barker, RH | 1 |
| Gervais, GW | 1 |
| Algarin, E | 1 |
| Serrano, AE | 1 |
| Müller, D | 1 |
| Blaschke, G | 1 |
| Norbury, CC | 1 |
| Thiéro, M | 1 |
| Ouedraogo, A | 1 |
| Packou, J | 1 |
| Souleymane, OA | 1 |
| Fané, M | 1 |
| Ade, G | 1 |
| Alvez, F | 1 |
| Doumbo, O | 1 |
| Mockenhaupt, FP | 1 |
| May, J | 1 |
| Bergqvist, Y | 1 |
| Meyer, CG | 1 |
| Falusi, AG | 1 |
| Bienzle, U | 1 |
| Moreno, A | 1 |
| Cuzin-Ouattara, N | 1 |
| Nebie, I | 1 |
| Sanon, S | 1 |
| Ndawi, B | 1 |
| Sheshe, AK | 1 |
| Byskov, J | 1 |
| Mbwana, K | 1 |
| Basco, LK | 1 |
| Ringwald, P | 1 |
| Maguire, JD | 1 |
| Susanti, AI | 1 |
| Sismadi, P | 1 |
| Fryauff, DJ | 1 |
| Baird, JK | 1 |
| Garin, B | 1 |
| Salun, JJ | 1 |
| Peyron, F | 1 |
| Vigier, JP | 1 |
| Busangu, I | 1 |
| Perrone, J | 1 |
| Bassett, MT | 1 |
| Taylor, P | 1 |
| Bvirakare, J | 1 |
| Chiteka, F | 1 |
| Govere, E | 1 |
| Trope, G | 1 |
| Shenton, FC | 1 |
| Bots, M | 1 |
| Menon, A | 1 |
| Eggelte, TA | 1 |
| de Wit, M | 1 |
| Greenwood, BM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Malaria Heart Disease Study: A Novel Pathway to Subclinical Heart Disease[NCT04445103] | 597 participants (Actual) | Observational | 2020-06-21 | Terminated (stopped due to Due to the COVID-19 pandemic it was not possible to complete the study inclusion as originally anticipated.) | |||
| New Tools for Diagnosis and Management of Febrile Illness in Travelers to the Tropics: a Cohort Study- JOKA I[NCT02900079] | 0 participants (Actual) | Observational [Patient Registry] | 2023-07-01 | Withdrawn (stopped due to delays in obtaining study materials) | |||
| Phase 2 Proof of Concept Study of a Candidate Aminoquinoline Antimalarial (AQ-13)[NCT01614964] | Phase 2 | 66 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for chloroquine and Sensitivity and Specificity
| Article | Year |
|---|---|
Hydroxychloroquine and chloroquine retinopathy: a systematic review evaluating the multifocal electroretinogram as a screening test.
Topics: Antirheumatic Agents; Chloroquine; Electroretinography; Fluorescein Angiography; Humans; Hydroxychlo | 2015 |
Plasmodium knowlesi: from Malaysia, a novel health care threat.
Topics: Animals; Anopheles; Antimalarials; Asia, Southeastern; Chloroquine; Insect Vectors; Macaca; Malaria; | 2012 |
Potential of high-performance liquid chromatography with photodiode array detection in forensic toxicology.
Topics: Adult; Azides; Chloroquine; Chromatography, High Pressure Liquid; Cocaine; Dothiepin; Female; Forens | 1997 |
3 trials available for chloroquine and Sensitivity and Specificity
| Article | Year |
|---|---|
Pharmacokinetic interactions between chloroquine, sulfadoxine and pyrimethamine and their bioequivalence in a generic fixed-dose combination in healthy volunteers in Uganda.
Topics: Administration, Oral; Adult; Antimalarials; Biological Availability; Chloroquine; Chromatography, Hi | 2006 |
Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Genotype; Heterodup | 2007 |
Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaoundé, Cameroon.
Topics: Adolescent; Adult; Animals; Antimalarials; Cameroon; Child; Chloroquine; Codon; Drug Resistance; Fem | 2001 |
77 other studies available for chloroquine and Sensitivity and Specificity
| Article | Year |
|---|---|
Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening.
Topics: Animals; Antimalarials; Benzothiazoles; Diamines; Drug Evaluation, Preclinical; Erythrocytes; Fluore | 2007 |
Improved assessment of plasmodium vivax response to antimalarial drugs by a colorimetric double-site plasmodium lactate dehydrogenase antigen capture enzyme-linked immunosorbent assay.
Topics: Adolescent; Adult; Animals; Antigens, Protozoan; Antimalarials; Child; Child, Preschool; Chloroquine | 2007 |
Metallocene-based antimalarials: an exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Ferrous Compounds; Metallocenes; Molecular Str | 2007 |
Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold.
Topics: Antimalarials; Cell Survival; Drug Discovery; Hep G2 Cells; Humans; Plasmodium falciparum; Quinazoli | 2017 |
Frequency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malaria.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Brazil; Case-Control Studies; Chlor | 2022 |
Highly Sensitive and Rapid Characterization of the Development of Synchronized Blood Stage Malaria Parasites Via Magneto-Optical Hemozoin Quantification.
Topics: Animals; Blood Chemical Analysis; Chloroquine; Disease Models, Animal; Early Diagnosis; Female; Heme | 2019 |
A Sensitive and Optimized HPLC-FLD Method for the Simultaneous Quantification of Hydroxychloroquine and Its Two Metabolites in Blood of Systemic Lupus Erythematosus Patients.
Topics: Adult; Chloroquine; Chromatography, High Pressure Liquid; Female; Humans; Hydroxychloroquine; Linear | 2020 |
Automated acoustic detection of mouse scratching.
Topics: Acoustics; Algorithms; Animals; Automation; Chloroquine; Mice, Inbred C57BL; Models, Theoretical; Pr | 2017 |
Evaluation of four novel isothermal amplification assays towards simple and rapid genotyping of chloroquine resistant Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Colorimetry; Coloring Agents; DNA, Protozoan; Drug Resistance; Ethidium; | 2018 |
Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.
Topics: Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Combined Modality Therapy; | 2013 |
Holographic analysis on deformation and restoration of malaria-infected red blood cells by antimalarial drug.
Topics: Antimalarials; Cell Size; Cell Tracking; Cells, Cultured; Chloroquine; Equipment Design; Equipment F | 2015 |
Assessment of the Worldwide Antimalarial Resistance Network Standardized Procedure for In Vitro Malaria Drug Sensitivity Testing Using SYBR Green Assay for Field Samples with Various Initial Parasitemia Levels.
Topics: Antimalarials; Artemisinins; Atovaquone; Benzothiazoles; Biological Assay; Chloroquine; Diamines; DN | 2016 |
Enantioselective determination of chloroquine and its n-dealkylated metabolites in plasma using liquid-phase microextraction and LC-MS.
Topics: 1-Octanol; Calibration; Chemical Fractionation; Chloroquine; Chromatography, Liquid; Humans; Hydroge | 2008 |
Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women.
Topics: Adult; Animals; Antigens, Protozoan; Antimalarials; Chloroquine; Drug Combinations; Female; Genotype | 2009 |
Nonradioactive heteroduplex tracking assay for the detection of minority-variant chloroquine-resistant Plasmodium falciparum in Madagascar.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Gene Amplification; G | 2009 |
A designer biomimetic vector with a chimeric architecture for targeted gene transfer.
Topics: Animals; Biomimetics; Cell Survival; Chloroquine; DNA; Endosomes; Gene Transfer Techniques; Genetic | 2009 |
Haemoglobin interference and increased sensitivity of fluorimetric assays for quantification of low-parasitaemia Plasmodium infected erythrocytes.
Topics: Animals; Benzothiazoles; Cell Separation; Chloroquine; Cytophotometry; Diamines; DNA, Protozoan; Ery | 2009 |
Rapid identification of chloroquine and atovaquone drug resistance in Plasmodium falciparum using high-resolution melt polymerase chain reaction.
Topics: Antimalarials; Atovaquone; Chloroquine; DNA, Protozoan; Drug Resistance; Haplotypes; Humans; Malaria | 2010 |
Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing.
Topics: Animals; CD11b Antigen; Chloroquine; Erythrocyte Count; Erythrocytes; Flow Cytometry; Hemeproteins; | 2011 |
Development of ELISA-based methods to measure the anti-malarial drug chloroquine in plasma and in pharmaceutical formulations.
Topics: Animals; Antibodies, Monoclonal; Antimalarials; Chemistry Techniques, Analytical; Chloroquine; Enzym | 2011 |
Development and validation of a capillary electrophoresis assay for the determination of the stereoisomeric purity of chloroquine enantiomers.
Topics: beta-Cyclodextrins; Chloroquine; Drug Contamination; Electrophoresis, Capillary; Linear Models; Repr | 2011 |
A modified serial blood sampling technique and utility of dried-blood spot technique in estimation of blood concentration: application in mouse pharmacokinetics.
Topics: Amodiaquine; Animals; Area Under Curve; Blood Specimen Collection; Chloroquine; Chlorthalidone; Chro | 2012 |
Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Monitoring; Female; Humans; Infant; Infant | 2011 |
Standby emergency treatment of malaria in travelers: experience to date and new developments.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Atovaquone; Chloroquine; Dia | 2012 |
Diagnosis of malaria by detection of plasmodial lactate dehydrogenase with an immunodot enzyme assay.
Topics: Animals; Antibodies, Protozoan; Antibody Specificity; Antimalarials; Chloroquine; Humans; Immunoblot | 2002 |
Diagnostic value of molecular markers in chloroquine-resistant falciparum malaria in Southern Mauritania.
Topics: Adult; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Female; Genet | 2002 |
A possible antiinflammatory treatment for cystic fibrosis.
Topics: Chloroquine; Clinical Trials as Topic; Cystic Fibrosis; Female; Humans; Male; Research; Sensitivity | 2003 |
The hospital- and field-based performances of the OptiMAL test, for malaria diagnosis and treatment monitoring in central India.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Combinations; False Negative Reactions; False Posit | 2003 |
Plasmodium falciparum: correlation of in vivo resistance to chloroquine and antifolates with genetic polymorphisms in isolates from the south of Lao PDR.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinat | 2003 |
Kinetics of DNA binding with chloroquine phosphate using capacitive sensing method.
Topics: Adsorption; Binding Sites; Biosensing Techniques; Chloroquine; DNA; Electric Capacitance; Electroche | 2003 |
Detection by real-time PCR of the Pfcrt T76 mutation, a molecular marker of chloroquine-resistant Plasmodium falciparum strains.
Topics: Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Genetic Markers; Humans; Malar | 2004 |
Prevalence of pfcrt mutations in Congolese and Malawian Plasmodium falciparum isolates as determined by a new Taqman assay.
Topics: Animals; Child, Preschool; Chloroquine; Democratic Republic of the Congo; DNA, Protozoan; Drug Resis | 2005 |
Reduced data acquisition time in multi-dimensional NMR spectroscopy using multiple-coil probes.
Topics: Chloroquine; Equipment Design; Magnetic Resonance Spectroscopy; Sensitivity and Specificity; Signal | 2005 |
Simultaneous determination of quinine and chloroquine anti-malarial agents in pharmaceuticals and biological fluids by HPLC and fluorescence detection.
Topics: Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Quini | 2005 |
Diagnostic and prognostic utility of an inexpensive rapid on site malaria diagnostic test (ParaHIT f) among ethnic tribal population in areas of high, low and no transmission in central India.
Topics: Adult; Antimalarials; Child; Chloroquine; Ethnicity; Female; Humans; India; Infant; Malaria, Falcipa | 2005 |
Use of a locked-nucleic-acid oligomer in the clamped-probe assay for detection of a minority Pfcrt K76T mutant population of Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Codon; DNA, Protozoan; Drug Resistance; Humans; Malaria, Falcip | 2005 |
An efficient PCR--SSCP-based method for detection of a chloroquine resistance marker in the PfCRT gene of Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Genetic Markers; Humans; India | 2006 |
Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Membrane P | 2006 |
Sensitive fluorescence HPLC assay for AQ-13, a candidate aminoquinoline antimalarial, that also detects chloroquine and N-dealkylated metabolites.
Topics: Alkylation; Antimalarials; Calibration; Chloroquine; Chromatography, High Pressure Liquid; Humans; Q | 2006 |
Plasmodium vivax: isotopic, PicoGreen, and microscopic assays for measuring chloroquine sensitivity in fresh and cryopreserved isolates.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Cryopreservation; Female; Fluorescent Dyes; | 2006 |
Can malaria be controlled where basic health services are not used?
Topics: Africa; Antimalarials; Chloroquine; Home Nursing; Hospitalization; Humans; Malaria; Mali; Patient Ac | 2006 |
Induction of splice correction by cell-penetrating peptide nucleic acids.
Topics: Cell Membrane Permeability; Chloroquine; Endocytosis; Gene Transfer Techniques; Genetic Diseases, In | 2006 |
Assessment of the drug susceptibility of Plasmodium falciparum clinical isolates from africa by using a Plasmodium lactate dehydrogenase immunodetection assay and an inhibitory maximum effect model for precise measurement of the 50-percent inhibitory conc
Topics: Africa; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Enzyme-Linked Immunosorbe | 2006 |
Antimalarial activity of sesquiterpene lactones from Vernonia cinerea.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; In Vitro Techniques; Lactones; Magnetic Resona | 2006 |
Very small injected samples to study chloroquine and quinine in human serum using capillary-LC and native fluorescence.
Topics: Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Fluorescence; Humans; Hydrogen-Ion | 2007 |
Sensitive and rapid liquid chromatography/tandem mass spectrometric assay for the quantification of chloroquine in dog plasma.
Topics: Animals; Antimalarials; Chloroquine; Chromatography, Liquid; Dogs; Reference Standards; Sensitivity | 2007 |
Diagnosis and treatment of malaria in peripheral health facilities in Uganda: findings from an area of low transmission in south-western Uganda.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Animals; Child; Child, Presc | 2007 |
Efficacy of murine monoclonal antibodies in RBC phenotyping of DAT-positive samples.
Topics: Anemia, Hemolytic, Autoimmune; Animals; Antibodies, Monoclonal; Autoantibodies; Blood Grouping and C | 2006 |
Capillary electrophoresis with end-column electrochemiluminescence for the analysis of chloroquine phosphate and the study on its interaction with human serum albumin.
Topics: Binding Sites; Chloroquine; Clomiphene; Electrochemistry; Electrophoresis, Capillary; Humans; Lumine | 2007 |
Analytical interferences of drugs in the chemical examination of urinary protein.
Topics: Chloroquine; Ciprofloxacin; Clinical Laboratory Techniques; Humans; Pharmaceutical Preparations; Pro | 2007 |
Clinical diagnosis of malaria and the risk of chloroquine self-medication in rural health centres in Burkina Faso.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Burkina Faso; Child; Child, Preschool; Ch | 2008 |
Allergen-stimulated interleukin-4 and interferon-gamma production in primary culture: responses of subjects with allergic rhinitis and normal controls.
Topics: Adolescent; Adult; Allergens; CD4-Positive T-Lymphocytes; Cells, Cultured; Chloroquine; Female; Huma | 1995 |
Analysis of basic antimalarial drugs by CZE; Part 2. Validation and application to bioanalysis.
Topics: Antimalarials; Calibration; Chloroquine; Chromatography; Electrophoresis; Humans; Injections; Progua | 1995 |
Simple and rapid HPLC of quinine, hydroxychloroquine, chloroquine, and desethylchloroquine in serum, whole blood, and filter paper-adsorbed dry blood.
Topics: Adsorption; Chloroquine; Chromatography, High Pressure Liquid; Humans; Hydroxychloroquine; Quinine; | 1994 |
Chloroquine bioassay using malaria microcultures.
Topics: Animals; Biological Assay; Chloroquine; Chromatography, High Pressure Liquid; Double-Blind Method; H | 1993 |
Five-compartment model of insulin kinetics and its use to investigate action of chloroquine in NIDDM.
Topics: Chloroquine; Diabetes Mellitus, Type 2; Humans; Insulin; Kinetics; Models, Biological; Sensitivity a | 1993 |
A quantification methodology of conversion rate based on field detected RI cases to RII-RIII cases--an approach for an alternative anti-malaria drug strategy.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Forecasting; Health Planning; | 1996 |
Chloroquine minimizes sampling artefacts for radioimmunological determination of thromboxane B2 in plasma.
Topics: Adult; Aged; Artifacts; Chloroquine; Coronary Disease; Female; Humans; Male; Middle Aged; Peripheral | 1997 |
Post treatment sensitivity studies with the ParaSight-F test for malaria diagnosis in Zimbabwe.
Topics: Antimalarials; Chloroquine; False Negative Reactions; False Positive Reactions; Humans; Malaria, Fal | 1997 |
Rapid and simple method to determine chloroquine and its desethylated metabolites in human microsomes by high-performance liquid chromatography with fluorescence detection.
Topics: Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Humans; Microsomes, Liver; Reprodu | 1997 |
Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Chloroquine; Drug Design; Drug Resistance; Heme; Plasmodium falciparum; Poly | 1998 |
Plasmodium falciparum: in vitro chloroquine susceptibility and allele-specific PCR detection of Pfmdr1 Asn86Tyr polymorphism in Lambarene, Gabon.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers; Chloroq | 1998 |
Allele-specific, nested, one tube PCR: application to Pfmdr1 polymorphisms in Plasmodium falciparum.
Topics: Alleles; Animals; Chloroquine; DNA Primers; Drug Resistance; Genes, MDR; Genes, Protozoan; Plasmodiu | 1999 |
Detection of color vision defects in chloroquine retinopathy.
Topics: Adult; Aged; Aged, 80 and over; Antimalarials; Case-Control Studies; Chloroquine; Color Perception T | 1999 |
Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Gambia; Hematocrit; Humans; Mala | 1999 |
Epidemiologic tools for malaria surveillance in an urban setting of low endemicity along the Colombian Pacific coast.
Topics: Animals; Antimalarials; Blood; Blotting, Southern; Chloroquine; Colombia; Cross-Sectional Studies; D | 2000 |
Enantioselective assay of chloroquine and its main metabolite deethyl chloroquine in human plasma by capillary electrophoresis.
Topics: Antimalarials; Calibration; Chloroquine; Electrophoresis, Capillary; Humans; Reference Standards; Re | 2000 |
Tracing the route taken by peptides and major histocompatibility complex class I molecules in presentation of exogenous antigens.
Topics: Amiloride; Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens; beta 2-Microglobulin; | 2001 |
Child malaria treatment practices among mothers in the district of Yanfolila, Sikasso region, Mali.
Topics: Adult; Antimalarials; Child, Preschool; Chloroquine; Female; Health Knowledge, Attitudes, Practice; | 2000 |
Evidence for a reduced effect of chloroquine against Plasmodium falciparum in alpha-thalassaemic children.
Topics: alpha-Thalassemia; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Stu | 2001 |
Use of the DELI-microtest to determine the drug sensitivity of Plasmodium falciparum in Burkina Faso.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Malaria, Falciparum; Mefloquine; Parasitemia; | 2001 |
Malaria diagnosis and treatment administered by teachers in primary schools in Tanzania.
Topics: Adolescent; Antimalarials; Child; Chloroquine; Delivery of Health Care; Female; Humans; Malaria, Fal | 2001 |
The T76 mutation in the pfcrt gene of Plasmodium falciparum and clinical chloroquine resistance phenotypes in Papua, Indonesia.
Topics: Adult; Alleles; Animals; Antigens, Protozoan; Antimalarials; Child; Chloroquine; Drug Resistance; Ge | 2001 |
Rapid in vivo detection of chloroquine resistance by the Quantitative Buffy Coat Malaria Diagnosis System.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum; Sensitivi | 1992 |
Clinical diagnosis of malaria: can we improve?
Topics: Chloroquine; Humans; Malaria; Medical History Taking; Parasitology; Predictive Value of Tests; Sensi | 1991 |
Value of Humphrey perimetry in the detection of early chloroquine retinopathy.
Topics: Aged; Chloroquine; Female; Humans; Prognosis; Retinal Diseases; Sensitivity and Specificity; Visual | 1989 |
An ELISA test for detecting chloroquine in urine.
Topics: Aminoquinolines; Antibodies, Monoclonal; Child, Preschool; Chloroquine; Colorimetry; Enzyme-Linked I | 1988 |