chloroquine has been researched along with Seizures in 36 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " They studied the effects of chloroquine, an antimutagenic with an optimal pharmacological profile for human use, as adjuvant for the treatment of patients with glioblastoma multiforme (GBM)." | 9.10 | Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine. ( Briceño, E; Reyes, S; Sotelo, J, 2003) |
| "These findings suggest that chloroquine does not play an important role in the aetiology of seizures in childhood cerebral malaria." | 9.09 | Chloroquine is not a risk factor for seizures in childhood cerebral malaria. ( Crawley, J; Kokwaro, G; Marsh, K; Ouma, D; Watkins, W, 2000) |
| "The goal of this systematic review is to assess the published literature for seizure risk with chloroquine or hydroxychloroquine therapy in persons with and without epilepsy." | 7.96 | Assessing the risk of seizures with chloroquine or hydroxychloroquine therapy for COVID-19 in persons with epilepsy. ( Houston, T; Pati, S, 2020) |
| "The effects of chloroquine on glial fibrillary acidic protein (GFAP), proliferation cell nuclear antigen (PCNA) and Cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole (PTZ) were observed in the present study." | 7.73 | Effects of chloroquine on GFAP, PCNA and cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole. ( Liu, Q; Wang, W; Zhang, S; Zhu, C, 2005) |
| "A case of tonic-clonic seizures following chloroquine treatment for leprosy reactions in a Nigerian male is reported." | 7.70 | Seizures following chloroquine treatment of type II lepra reaction: a case report. ( Ebenso, BE, 1998) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 7.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "Chloroquine poisoning in children, although infrequent, is extremely dangerous because of the narrow margin between therapeutic and toxic doses." | 7.68 | Chloroquine poisoning in a child. ( Bernard, WD; Kelly, JC; Knapp, J; Schultz, C; Wasserman, GS, 1990) |
| "Seizures were induced by pentylenetetrazol and maximal electroshock." | 5.72 | Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022) |
| "He had a single grand mal seizure 37 days following retreatment with quinine intravenously, which resulted in rapid clearance of fever and parasitemia, in addition to mefloquine." | 5.29 | [A case of mefloquine-resistant Plasmodium falciparum malaria with convulsion after antimalarial treatment]. ( Aoki, M; Kamei, K; Miyashita, T; Nishiya, H; Ohyatsu, I; Ono, Y; Shibuya, T; Sugiyama, H; Tokumura, Y; Yamaguchi, M, 1994) |
| " They studied the effects of chloroquine, an antimutagenic with an optimal pharmacological profile for human use, as adjuvant for the treatment of patients with glioblastoma multiforme (GBM)." | 5.10 | Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine. ( Briceño, E; Reyes, S; Sotelo, J, 2003) |
| "These findings suggest that chloroquine does not play an important role in the aetiology of seizures in childhood cerebral malaria." | 5.09 | Chloroquine is not a risk factor for seizures in childhood cerebral malaria. ( Crawley, J; Kokwaro, G; Marsh, K; Ouma, D; Watkins, W, 2000) |
| "The goal of this systematic review is to assess the published literature for seizure risk with chloroquine or hydroxychloroquine therapy in persons with and without epilepsy." | 3.96 | Assessing the risk of seizures with chloroquine or hydroxychloroquine therapy for COVID-19 in persons with epilepsy. ( Houston, T; Pati, S, 2020) |
| "The effects of chloroquine on glial fibrillary acidic protein (GFAP), proliferation cell nuclear antigen (PCNA) and Cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole (PTZ) were observed in the present study." | 3.73 | Effects of chloroquine on GFAP, PCNA and cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole. ( Liu, Q; Wang, W; Zhang, S; Zhu, C, 2005) |
| "A case of tonic-clonic seizures following chloroquine treatment for leprosy reactions in a Nigerian male is reported." | 3.70 | Seizures following chloroquine treatment of type II lepra reaction: a case report. ( Ebenso, BE, 1998) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 3.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| " Streptomycin, chloroquine and abortificients were used during early pregnancy." | 3.68 | Deafness in children--an analysis. ( Ganga, N; Padmanabhan, AS; Rajagopal, B; Rajendran, S, 1991) |
| "Chloroquine poisoning in children, although infrequent, is extremely dangerous because of the narrow margin between therapeutic and toxic doses." | 3.68 | Chloroquine poisoning in a child. ( Bernard, WD; Kelly, JC; Knapp, J; Schultz, C; Wasserman, GS, 1990) |
| "Seizures were induced by pentylenetetrazol and maximal electroshock." | 1.72 | Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022) |
| "Chloroquine has long been used for the treatment of malaria and rheumatological disorders." | 1.43 | Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. ( Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A, 2016) |
| "Bilateral anterior shoulder dislocation is a rare clinical entity with few case reports and limited series published in the literature." | 1.43 | Chloroquine-induced bilateral anterior shoulder dislocation: a unique aetiology for a rare clinical problem. ( Martin, AN; Rossouw, D; Tsekes, D; White, WJ, 2016) |
| "Quinine is the drug of choice for the treatment of cerebral malaria 87." | 1.32 | Assessment of doctors' management of severe malaria in urban centres in Eastern Nigeria. ( Ele, PU; Ibeh, CC; Ukpabi, OJ, 2004) |
| "Refractory seizures not responding to benzodiazepine may require an antiepileptic drug." | 1.31 | Chloroquine poisoning: report of two cases. ( Reddy, VG; Sinna, S, 2000) |
| "Malaria is a major cause of death among children in many parts of the world, even though simple and effective treatments exist." | 1.31 | Patterns of care for childhood malaria in Zambia. ( Baume, C; Helitzer, D; Kachur, SP, 2000) |
| "He had a single grand mal seizure 37 days following retreatment with quinine intravenously, which resulted in rapid clearance of fever and parasitemia, in addition to mefloquine." | 1.29 | [A case of mefloquine-resistant Plasmodium falciparum malaria with convulsion after antimalarial treatment]. ( Aoki, M; Kamei, K; Miyashita, T; Nishiya, H; Ohyatsu, I; Ono, Y; Shibuya, T; Sugiyama, H; Tokumura, Y; Yamaguchi, M, 1994) |
| "Of the 134 seizure cases seen, febrile convulsion (FC) formed the majority (55%) with cerebral malaria (CM) as the only major (33%) rival." | 1.29 | Upsurge of malaria-related convulsions in a paediatric emergency room in Nigeria. Consequence of emergence of chloroquine-resistant Plasmodium falciparum. ( Asindi, AA; Ekanem, EE; Ibia, EO; Nwangwa, MA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (36.11) | 18.7374 |
| 1990's | 12 (33.33) | 18.2507 |
| 2000's | 7 (19.44) | 29.6817 |
| 2010's | 2 (5.56) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Boroujeni, SS | 1 |
| Solaimanian, S | 1 |
| Jafari, RM | 1 |
| Sabzevari, O | 1 |
| Shafaroodi, H | 1 |
| Maleki, A | 1 |
| Mohammadi, P | 1 |
| Karimi, E | 1 |
| Dehpour, AR | 2 |
| Pati, S | 1 |
| Houston, T | 1 |
| Hassanipour, M | 1 |
| Shirzadian, A | 1 |
| Boojar, MM | 1 |
| Abkhoo, A | 2 |
| Delazar, S | 1 |
| Amiri, S | 1 |
| Rahimi, N | 1 |
| Ostadhadi, S | 1 |
| Martin, AN | 1 |
| Tsekes, D | 1 |
| White, WJ | 1 |
| Rossouw, D | 1 |
| SPILLANE, JD | 1 |
| ROSENBERG, FJ | 1 |
| BOTTIROLI, JA | 1 |
| MIZUNO, T | 1 |
| MARKOWITZ, HA | 1 |
| MCGINLEY, JM | 1 |
| HART, CW | 1 |
| NAUNTON, RF | 1 |
| MITCHELL, CL | 1 |
| Tristano, AG | 1 |
| Falcón, L | 1 |
| Willson, M | 1 |
| de Oca, IM | 1 |
| Ibeh, CC | 1 |
| Ele, PU | 1 |
| Ukpabi, OJ | 1 |
| Briceño, E | 1 |
| Reyes, S | 1 |
| Sotelo, J | 1 |
| Zhang, S | 1 |
| Zhu, C | 1 |
| Liu, Q | 1 |
| Wang, W | 1 |
| Miyashita, T | 1 |
| Tokumura, Y | 1 |
| Nishiya, H | 1 |
| Sugiyama, H | 1 |
| Yamaguchi, M | 1 |
| Ohyatsu, I | 1 |
| Aoki, M | 1 |
| Ono, Y | 1 |
| Kamei, K | 1 |
| Shibuya, T | 1 |
| Asindi, AA | 1 |
| Ekanem, EE | 1 |
| Ibia, EO | 1 |
| Nwangwa, MA | 1 |
| Courtois, X | 1 |
| Vincent, F | 1 |
| Legoff, F | 1 |
| Bhatia, MS | 1 |
| Malik, SC | 1 |
| Dixon, JM | 1 |
| Plotkin, SA | 1 |
| Loupi, E | 1 |
| Lang, J | 1 |
| Ebenso, BE | 1 |
| Reddy, VG | 1 |
| Sinna, S | 1 |
| Baume, C | 1 |
| Helitzer, D | 1 |
| Kachur, SP | 1 |
| Crawley, J | 1 |
| Kokwaro, G | 1 |
| Ouma, D | 1 |
| Watkins, W | 1 |
| Marsh, K | 1 |
| Osifo, NG | 1 |
| DiStefano, V | 1 |
| Tempe, JD | 1 |
| Jaeger, A | 1 |
| Beissel, J | 1 |
| Burg, F | 1 |
| Mantz, JM | 1 |
| Berner, H | 1 |
| Amabeoku, G | 1 |
| Ganga, N | 1 |
| Rajagopal, B | 1 |
| Rajendran, S | 1 |
| Padmanabhan, AS | 1 |
| Brewster, DR | 1 |
| Kwiatkowski, D | 1 |
| White, NJ | 1 |
| Sopeña, B | 1 |
| Fernández Rodríguez, C | 1 |
| Ledo, L | 1 |
| Rodríguez, D | 1 |
| Kelly, JC | 1 |
| Wasserman, GS | 1 |
| Bernard, WD | 1 |
| Schultz, C | 1 |
| Knapp, J | 1 |
| Patel, CC | 1 |
| Olurin, O | 1 |
| Phansalkar, AG | 1 |
| Kulkarni, SD | 1 |
| Balwani, JH | 1 |
| Stanfield, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chloroquine as Adjuvant to the Treatment of Glioblastoma Multiforme, A Randomized Trial[NCT00224978] | Phase 3 | 0 participants | Interventional | 2005-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chloroquine and Seizures
| Article | Year |
|---|---|
Neurological sequelae of cerebral malaria in children.
Topics: Adolescent; Animals; Antimalarials; Brain Diseases; Child; Chloroquine; Coma; Follow-Up Studies; Gam | 1990 |
2 trials available for chloroquine and Seizures
| Article | Year |
|---|---|
Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine.
Topics: Adolescent; Adult; Antimutagenic Agents; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuv | 2003 |
Chloroquine is not a risk factor for seizures in childhood cerebral malaria.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Double-Blind Method; Female; Humans | 2000 |
33 other studies available for chloroquine and Seizures
| Article | Year |
|---|---|
Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice.
Topics: Animals; Anticonvulsants; Chloroquine; Disease Models, Animal; Electroshock; Mefloquine; Mice; Naltr | 2022 |
Assessing the risk of seizures with chloroquine or hydroxychloroquine therapy for COVID-19 in persons with epilepsy.
Topics: Adolescent; Adult; Aged; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Dr | 2020 |
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease M | 2016 |
Chloroquine-induced bilateral anterior shoulder dislocation: a unique aetiology for a rare clinical problem.
Topics: Adult; Braces; Chloroquine; Fractures, Comminuted; Humans; Male; Seizures; Shoulder Dislocation; Tre | 2016 |
IATROGENIC NEUROLOGICAL DISEASES. DRUG-INDUCED NEUROLOGICAL DISORDERS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antihypertensive Agents | 1964 |
ANTIMALARIALS AND OTHER ANTICONVULSANT DRUGS: PREDICTIVE VALIDITY OF LABORATORY TESTS.
Topics: Animals; Anticonvulsants; Antimalarials; Chloroquine; Electric Stimulation; Hydroxychloroquine; Mice | 1964 |
[DIAGNOSIS AND THERAPY OF CONVULSIVE DISEASES IN CHILDHOOD].
Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Amino Acids; Barbiturates; Brain Diseases; C | 1964 |
CHLOROQUINE POISONING IN A CHILD.
Topics: Child; Chloroquine; Gastric Lavage; Intubation; Intubation, Intratracheal; Movement Disorders; Poiso | 1964 |
THE OTOTOXICITY OF CHLOROQUINE PHOSPHATE.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Ataxia; Cerebellar Diseases; Child; Chloroquine; Coc | 1964 |
THE ABSENCE OF ANTICONVULSANT PROPERTIES OF QUINACRINE AND CHLOROQUINE IN MICE.
Topics: Anticonvulsants; Chloroquine; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Quinacrine; Res | 1964 |
Seizure associated with chloroquine therapy in a patient with systemic lupus erythematosus.
Topics: Adolescent; Anticonvulsants; Antirheumatic Agents; Causality; Chloroquine; Female; Humans; Lupus Ery | 2004 |
Assessment of doctors' management of severe malaria in urban centres in Eastern Nigeria.
Topics: Adult; Analgesics; Analgesics, Non-Narcotic; Anemia; Antimalarials; Blood Transfusion; Chloroquine; | 2004 |
Effects of chloroquine on GFAP, PCNA and cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole.
Topics: Animals; Cerebral Cortex; Chloroquine; Cyclin D1; Glial Fibrillary Acidic Protein; Hippocampus; Male | 2005 |
[A case of mefloquine-resistant Plasmodium falciparum malaria with convulsion after antimalarial treatment].
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Male; Mefloquine; Seizure | 1994 |
Upsurge of malaria-related convulsions in a paediatric emergency room in Nigeria. Consequence of emergence of chloroquine-resistant Plasmodium falciparum.
Topics: Age Factors; Child; Child, Preschool; Chloroquine; Drug Resistance; Emergency Service, Hospital; Hos | 1993 |
[Convulsive seizures after prevention with chloroquine].
Topics: Adult; Chloroquine; Humans; Male; Seizures | 1993 |
Psychiatric complications of chloroquine.
Topics: Antimalarials; Case-Control Studies; Child; Chloroquine; Humans; India; Mental Disorders; Seizures | 1995 |
Doctors should check datasheets.
Topics: Child; Chloroquine; Drug Information Services; Drug Labeling; Humans; Male; Seizures | 1996 |
Bali Low.
Topics: Chloroquine; Humans; Immunization, Passive; Male; Rabies Vaccines; Seizures | 1997 |
Seizures following chloroquine treatment of type II lepra reaction: a case report.
Topics: Adult; Chloroquine; Humans; Leprosy, Borderline; Leprosy, Lepromatous; Male; Seizures | 1998 |
Chloroquine poisoning: report of two cases.
Topics: Adult; Anticonvulsants; Antidotes; Antimalarials; Charcoal; Chloroquine; Coma; Diazepam; Drug Overdo | 2000 |
Patterns of care for childhood malaria in Zambia.
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Female; Fever; Health Care Surveys; | 2000 |
Enhanced lethality and tissue levels of chloroquine in rats pretreated with pyrogen.
Topics: Animals; Chloroquine; Drug Interactions; Lethal Dose 50; Male; Pyrogens; Rats; Respiration; Seizures | 1978 |
[Acute intoxications due to cardiotropic drugs : ajmaline, chloroquine and digitalin].
Topics: Acute Disease; Adolescent; Adult; Ajmaline; Chloroquine; Coma; Digitalis Glycosides; Female; Humans; | 1976 |
[Malaria in children, with special reference to cerebral malaria (author's transl)].
Topics: Age Factors; Anemia, Hemolytic; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; Chloroquine | 1975 |
Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Chloroquine; Diazepam; gamma-Aminobutyric Ac | 1992 |
Deafness in children--an analysis.
Topics: Abortifacient Agents; Adolescent; Chickenpox; Child; Child, Preschool; Chloroquine; Deafness; Female | 1991 |
[Convulsions induced by a metronidazole-chloroquine combination].
Topics: Chloroquine; Humans; Male; Metronidazole; Middle Aged; Seizures | 1990 |
Chloroquine poisoning in a child.
Topics: Apnea; Arrhythmias, Cardiac; Chloroquine; Female; Humans; Infant; Poisoning; Seizures | 1990 |
Acute febrile encephalopathy in Ugandan children.
Topics: Cerebrospinal Fluid; Child; Child, Preschool; Chloroquine; Encephalitis; Female; Fever; Gastrointest | 1971 |
Cortical blindness following convulsions and fever in Nigerian children.
Topics: Anti-Bacterial Agents; Anticonvulsants; Blindness; Blood Transfusion; Bronchopneumonia; Cerebral Cor | 1970 |
Influence of some antiarrhythmic agents on electrically induced convulsive seizures in rats.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Chloroquine; Electroshock; Female; Lidocaine; Male | 1970 |
Fever in children in the tropics.
Topics: Anti-Bacterial Agents; Aspirin; Child; Child, Preschool; Chloroquine; Fever; Humans; Hypothermia; Ph | 1969 |