chloroquine has been researched along with Scotoma in 32 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Scotoma: A localized defect in the visual field bordered by an area of normal vision. This occurs with a variety of EYE DISEASES (e.g., RETINAL DISEASES and GLAUCOMA); OPTIC NERVE DISEASES, and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A simple scheme for rendering patients ophthalmologically safe is presented, employing the recording of central fields to red targets." | 6.63 | Chloroquine: ophthalmological safety, and clinical assessment in rheumatoid arthritis. ( Meanock, I; Percival, SP, 1968) |
| "A 60-year-old woman presented for routine ocular examination with a medical history of severe rheumatoid arthritis, for which she had been receiving 3 mg chloroquine (CQ) per kilogram for the past 17 years." | 3.76 | Macular sensitivity changes for detection of chloroquine toxicity in asymptomatic patient. ( Angi, M; Romano, F; Romano, MR; Romano, V; Valldeperas, X, 2010) |
| "A 59-year-old man took a daily dosage of 250 mg chloroquine for his rheumatoid arthritis (up to a total dose of 540 g)." | 3.74 | Electrophysiologic findings in chloroquine maculopathy. ( Halfeld Furtado de Mendonça, R; Maia, OO; Yukihiko Takahashi, W, 2007) |
| " Differential diagnoses include Leber's congenital amaurosis, central gyrate atrophy, central areolar choroidal sclerosis, progressive cone-rod dystrophy, syphilitic retinopathy, retinal toxicity from phenothiazine use, and chloroquine/hydroxychloroquine retinopathy." | 3.70 | Retinitis pigmentosa inversa. ( Anderson, SF; Ferrucci, S; Townsend, JC, 1998) |
| "Delayed-onset chloroquine retinopathy was diagnosed in a patient seven years after cessation of treatment by a total dose of 730 g of chloroquine for rheumatoid arthritis." | 3.67 | Delayed-onset chloroquine retinopathy. ( Ehrenfeld, M; Merin, S; Nesher, R, 1986) |
| " A simple scheme for rendering patients ophthalmologically safe is presented, employing the recording of central fields to red targets." | 2.63 | Chloroquine: ophthalmological safety, and clinical assessment in rheumatoid arthritis. ( Meanock, I; Percival, SP, 1968) |
| "All cases arose because of failure by physicians to avoid dosing above published safe levels." | 1.31 | Hydroxychloroquine and chloroquine retinopathy: screening for drug toxicity. ( Browning, DJ, 2002) |
| "Four cases of irreversible bilateral scotomas were detected in 8 eyes of 4 patients with normal static and kinetic fields in 7 of the 8 eyes." | 1.27 | The sensitivity of Amsler grid testing in early chloroquine retinopathy. ( Easterbrook, M, 1985) |
| "Surgical treatment of cataracts, band keratopathy, and glaucoma achieved uniformly discouraging results." | 1.25 | Ocular manifestations of juvenile rheumatoid arthritis. ( Bellows, AR; Bienfang, DC; Chylack, LT; Stillman, JS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (81.25) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Angi, M | 1 |
| Romano, V | 1 |
| Valldeperas, X | 1 |
| Romano, F | 1 |
| Romano, MR | 1 |
| Gentille Lorente, DI | 1 |
| VOIPIO, H | 1 |
| REISSEL, P | 1 |
| ALGVERE, P | 1 |
| CARLBERG, O | 1 |
| ERICSON, L | 1 |
| HERMANN, P | 1 |
| SOURDILLE, P | 1 |
| COVO, Y | 1 |
| GALDETTI, M | 1 |
| PINHAS, Y | 1 |
| DEVRIES, A | 1 |
| LAMERS, WP | 1 |
| VOIPOI, H | 1 |
| REISSELL, P | 1 |
| LLOYD, LA | 1 |
| HILTZ, JW | 1 |
| REED, H | 1 |
| CAMPBELL, AA | 1 |
| Halfeld Furtado de Mendonça, R | 1 |
| Maia, OO | 1 |
| Yukihiko Takahashi, W | 1 |
| Le Rebeller, MJ | 1 |
| Lanneluc, C | 1 |
| Lotte, C | 1 |
| Ferrucci, S | 1 |
| Anderson, SF | 1 |
| Townsend, JC | 1 |
| Browning, DJ | 1 |
| Brinkley, JR | 1 |
| Dubois, EL | 1 |
| Ryan, SJ | 1 |
| Chylack, LT | 1 |
| Bienfang, DC | 1 |
| Bellows, AR | 1 |
| Stillman, JS | 1 |
| Easterbrook, M | 2 |
| Ehrenfeld, M | 1 |
| Nesher, R | 1 |
| Merin, S | 1 |
| François, J | 1 |
| de Rouck, A | 1 |
| Cambie, E | 1 |
| de Laey, JJ | 1 |
| Nylander, U | 2 |
| Percival, SP | 1 |
| Meanock, I | 1 |
| Smiley, WK | 1 |
| Godel, V | 1 |
| Nemet, P | 1 |
| Stein, R | 1 |
| Podos, SM | 1 |
| Meadows, SP | 1 |
| Newman, M | 1 |
| Carr, RE | 1 |
| Bertrand, JJ | 1 |
| Debeyre, N | 1 |
| Kahn, MF | 1 |
| Ryckewaert, A | 1 |
| Kearns, TP | 2 |
| Hollenhorst, RW | 2 |
1 review available for chloroquine and Scotoma
| Article | Year |
|---|---|
The eye in arthritis.
Topics: Adrenal Cortex Hormones; Adult; Antimalarials; Arthritis; Arthritis, Juvenile; Arthritis, Reactive; | 1969 |
1 trial available for chloroquine and Scotoma
| Article | Year |
|---|---|
Chloroquine: ophthalmological safety, and clinical assessment in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chloroquine; Clinical Trials as Topic; Color Vision Defects; Cor | 1968 |
30 other studies available for chloroquine and Scotoma
| Article | Year |
|---|---|
Macular sensitivity changes for detection of chloroquine toxicity in asymptomatic patient.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Early Diagnosis; Female; Fixation, Ocular; | 2010 |
[Ocular and cardiac toxicity by chloroquine].
Topics: Antimalarials; Chloroquine; Female; Heart Block; Humans; Lupus Erythematosus, Systemic; Middle Aged; | 2011 |
[Chloroquine-induced retinopathia].
Topics: Chloroquine; Cornea; Humans; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Retina; Sc | 1963 |
RETINAL DAMAGE IN CHLOROQUINE THERAPY.
Topics: Arthritis; Arthritis, Rheumatoid; Blindness; Chloroquine; Color Vision Defects; Humans; Lupus Erythe | 1963 |
[OCULAR LESIONS INDUCED BY A SYNTHETIC ANTIMALARIAL AGENT].
Topics: Antimalarials; Chloroquine; Eye; Hyperplasia; Hypertrophy; Iritis; Retinitis; Scotoma; Toxicology | 1963 |
[MYOSITIS AND PARACENTRAL SCOTOMA DUE TO EMETINE AND ARALEN THERAPIES].
Topics: Chloroquine; Emetine; Myositis; Scotoma; Toxicology | 1963 |
[RETINOPATHY FOLLOWING PROLONGED CHLOQUINE (NIVAQUINE) USE].
Topics: Chloroquine; Electroretinography; Ophthalmology; Retina; Retinal Diseases; Scotoma; Toxicology | 1964 |
[CHLOROQUINE-INDUCED RETINOPATHY].
Topics: Chloroquine; Cornea; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Ophthalmology; Ret | 1963 |
OCULAR COMPLICATIONS OF CHLOROQUINE THERAPY.
Topics: Arthritis, Rheumatoid; Blindness; Chloroquine; Collagen Diseases; Cornea; Corneal Opacity; Drug Ther | 1965 |
Central scotomata following chloroquine therapy.
Topics: Chloroquine; Humans; Scotoma | 1962 |
Electrophysiologic findings in chloroquine maculopathy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Electrodiagnosis; Electrooculography; Elec | 2007 |
[Monitoring and prevention of iatrogenic ocular effect in general therapy].
Topics: Adult; Aged; Antimalarials; Chloroquine; Ethambutol; Eye Diseases; Humans; Male; Middle Aged; Scotom | 1981 |
Retinitis pigmentosa inversa.
Topics: Adult; Atrophy; Blindness; Chloroquine; Diagnosis, Differential; Follow-Up Studies; Humans; Hydroxyc | 1998 |
Hydroxychloroquine and chloroquine retinopathy: screening for drug toxicity.
Topics: Aged; Antirheumatic Agents; Chloroquine; Dermatologic Agents; Drug-Related Side Effects and Adverse | 2002 |
Long-term course of chloroquine retinopathy after cessation of medication.
Topics: Adult; Aged; Chloroquine; Color Perception Tests; Female; Fluorescein Angiography; Follow-Up Studies | 1979 |
Ocular manifestations of juvenile rheumatoid arthritis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Arthritis, Juvenile; Atropine; Cataract; Ch | 1975 |
Long-term course of antimalarial maculopathy after cessation of treatment.
Topics: Chloroquine; Follow-Up Studies; Humans; Hydroxychloroquine; Longitudinal Studies; Macula Lutea; Mala | 1992 |
The sensitivity of Amsler grid testing in early chloroquine retinopathy.
Topics: Adult; Chloroquine; Humans; Hydroxychloroquine; Retinal Diseases; Scotoma; Vision Tests | 1985 |
Delayed-onset chloroquine retinopathy.
Topics: Arthritis, Rheumatoid; Chloroquine; Electrooculography; Female; Humans; Middle Aged; Retinal Disease | 1986 |
[Chloroquine retinopathy].
Topics: Adult; Aged; Chloroquine; Color Vision Defects; Dark Adaptation; Electrooculography; Electroretinogr | 1972 |
Ocular damage in chloroquine therapy.
Topics: Adult; Arthritis, Rheumatoid; Child; Chloroquine; Color Perception Tests; Color Vision Defects; Corn | 1967 |
[Ocular involvement in chloroquine therapy].
Topics: Adult; Angiography; Chloroquine; Corneal Opacity; Dark Adaptation; Electroretinography; Eye Diseases | 1972 |
Retinal pigmentary disease.
Topics: Adolescent; Adult; Blindness; Brain Diseases; Chloroquine; Chorioretinitis; Choroid; Diagnosis, Diff | 1967 |
Visual failure and optic atrophy.
Topics: Adult; Amblyopia; Anemia, Pernicious; Child; Chloroquine; Craniocerebral Trauma; Cyanides; Female; H | 1970 |
Modern techniques in perimetry.
Topics: Adaptation, Ocular; Adolescent; Adult; Amblyopia; Brain Diseases; Chloroquine; Chorioretinitis; Eye | 1967 |
Chloroquine and organic changes in the eye.
Topics: Chloroquine; Diagnosis, Differential; Electrooculography; Electroretinography; Eye Diseases; Female; | 1968 |
[Supervision of the eyes during prolonged treatment with synthetic antimalarial drugs. Results in 237 patients followed up for 4 years on the average].
Topics: Antimalarials; Chloroquine; Corneal Opacity; Drug Tolerance; Electroretinography; Eye Diseases; Hydr | 1968 |
Chloroquine retinopathy. Evaluation by fluorescein fundus angiography.
Topics: Angiography; Chloroquine; Eye Diseases; Fluoresceins; Fundus Oculi; Ophthalmoscopy; Photography; Ret | 1966 |
Ocular damage in chloroquine therapy.
Topics: Arthritis; Chloroquine; Color Perception; Electroretinography; Eye Diseases; Female; Humans; Lupus E | 1966 |
Chloroquine retinopathy: evaluation by fluorescein fundus angiography.
Topics: Chloroquine; Eye Diseases; Female; Fluoresceins; Fundus Oculi; Humans; Middle Aged; Ophthalmoscopy; | 1966 |