chloroquine has been researched along with Retinoblastoma in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the inhibition of retinoblastoma cell viability by two commonly used autophagy inhibitors, chloroquine (CQ) and 3-methyladenine (3-MA), alone or in combination with the conventional chemotherapeutic drug vincristine (VCR), and to investigate whether the mechanisms of these drugs are related to inhibition of autophagy." | 7.81 | Low concentrations of chloroquine and 3-methyladenine suppress the viability of retinoblastoma cells synergistically with vincristine independent of autophagy inhibition. ( Chen, X; Chen, YH; Jiang, PF; Li, LJ; Li, W; Shen, HQ; Zheng, XY, 2015) |
| "To study the inhibition of retinoblastoma cell viability by two commonly used autophagy inhibitors, chloroquine (CQ) and 3-methyladenine (3-MA), alone or in combination with the conventional chemotherapeutic drug vincristine (VCR), and to investigate whether the mechanisms of these drugs are related to inhibition of autophagy." | 3.81 | Low concentrations of chloroquine and 3-methyladenine suppress the viability of retinoblastoma cells synergistically with vincristine independent of autophagy inhibition. ( Chen, X; Chen, YH; Jiang, PF; Li, LJ; Li, W; Shen, HQ; Zheng, XY, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, XY | 1 |
| Li, LJ | 1 |
| Li, W | 1 |
| Jiang, PF | 1 |
| Shen, HQ | 1 |
| Chen, YH | 1 |
| Chen, X | 1 |
| Mäenpää, H | 1 |
| Toimela, T | 1 |
| Mannerström, M | 1 |
| Saransaari, P | 1 |
| Tähti, H | 1 |
| Safi, N | 3 |
| Blanquet, P | 3 |
| Basse-Cathalina, B | 1 |
| Ducassou, D | 1 |
| Verin, P | 2 |
| Vérin, PH | 1 |
| Frayer, WC | 1 |
1 review available for chloroquine and Retinoblastoma
| Article | Year |
|---|---|
Recent advances in pediatric ophthalmology.
Topics: Child, Preschool; Chloroquine; Eye Diseases; Eye Neoplasms; Herpes Zoster Ophthalmicus; Humans; Infa | 1968 |
5 other studies available for chloroquine and Retinoblastoma
| Article | Year |
|---|---|
Low concentrations of chloroquine and 3-methyladenine suppress the viability of retinoblastoma cells synergistically with vincristine independent of autophagy inhibition.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Antirheumatic Agents; Apoptosis; Autophagy; Blotting, We | 2015 |
Toxicity of selected cationic drugs in retinoblastomal cultures and in cocultures of retinoblastomal and retinal pigment epithelial cell lines.
Topics: Cations; Cell Line; Cell Survival; Chloroquine; Coculture Techniques; Estrogen Receptor Modulators; | 2004 |
Radionuclidic explorations in ophthalmology.
Topics: Chloroquine; Diabetic Retinopathy; Eye Neoplasms; Fluoresceins; Glaucoma; Hemangioma; Humans; Iodine | 1975 |
[Ocular radio isotope scanning. Instrumentation. Vectors. Medothology].
Topics: Chloroquine; Choroiditis; Eye Neoplasms; Fluoresceins; Hemangioma; Humans; Iodine Radioisotopes; Mel | 1974 |
[Ocular scintigraphy].
Topics: Chloroquine; Choroiditis; Diagnosis, Differential; Eye; Eye Diseases; Eye Neoplasms; Fluoresceins; H | 1974 |