chloroquine has been researched along with Retinal Degeneration in 28 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Corneal opacity, reversible retinal lipidosis and irreversible receptor cell degeneration are known to occur after long-term treatment with chloroquine." | 1.29 | Chloroquine-induced lipidosis in the rat retina: a functional and morphological study. ( Bredehorn, T; Duncker, G; Schmiederer, M, 1995) |
| "It is known to cause lipidosis and photoreceptor degeneration in the human and the rat retina." | 1.29 | Chloroquine-induced lipidosis in the rat retina: functional and morphological changes after withdrawal of the drug. ( Bredehorn, T; Duncker, G, 1996) |
| "In untreated rheumatoid arthritis 20% of the patients has a EOG Lp/Dt ratio lower than the lower 5% limit calculated for normal patients." | 1.27 | The EOG in rheumatoid arthritis. ( Broekhuyse, RM; Pinckers, A, 1983) |
| "A case of maculopathy mimicking chloroquine toxicity without exposure to the drug is described." | 1.26 | Retinal vascular changes in bull's eye maculopathy. ( Chopdar, A, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (92.86) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SMITH, JL | 1 |
| PENNER, R | 1 |
| SOMERS, K | 1 |
| Pinckers, A | 1 |
| Broekhuyse, RM | 1 |
| Duncker, G | 2 |
| Schmiederer, M | 1 |
| Bredehorn, T | 2 |
| Meyer, JJ | 1 |
| Korol, S | 1 |
| Babel, J | 1 |
| Miyata, M | 1 |
| Nasu, K | 3 |
| Chopdar, A | 1 |
| Bonnet, M | 1 |
| Leroy, D | 1 |
| Meier-Ruge, W | 1 |
| Deutman, AF | 1 |
| van Lith, GH | 1 |
| Krause, A | 1 |
| Beetz, S | 1 |
| Barg, TsM | 1 |
| François, J | 1 |
| Lakowski, R | 1 |
| Thaler, A | 1 |
| Heilig, P | 1 |
| Slezak, H | 1 |
| Branchevskaia, SIa | 1 |
| Weise, EE | 1 |
| Yannuzzi, LA | 1 |
| Adlakha, D | 1 |
| Crews, SJ | 1 |
| Shearer, AC | 1 |
| Tonks, EL | 1 |
| Berato, J | 1 |
| Commandre, F | 1 |
| Albatro, J | 1 |
| Gilly, R | 1 |
| Paufique, L | 1 |
| Magnard, P | 1 |
| Weinstein, GW | 1 |
| Weinberg, RS | 1 |
| Hobson, RR | 1 |
| Hodgkinson, BJ | 1 |
| Kolb, H | 1 |
| Tsuchida, Y | 1 |
| Kawasaki, K | 1 |
| Jacobson, JH | 1 |
| Sobrepere, G | 1 |
| Rampin, S | 1 |
| Farnarier, G | 1 |
1 review available for chloroquine and Retinal Degeneration
| Article | Year |
|---|---|
[Eye complications during use of various medicinal substances with general effects (review of the literature)].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Allopurinol; Anti-Bacterial Agents; Antimalari | 1969 |
27 other studies available for chloroquine and Retinal Degeneration
| Article | Year |
|---|---|
Chloroquine macular degeneration.
Topics: Blindness; Chloroquine; Disease; Humans; Macula Lutea; Macular Degeneration; Retinal Degeneration | 1962 |
Bilateral macular degeneration associated with chloroquine therapy.
Topics: Chloroquine; Disease; Humans; Macula Lutea; Macular Degeneration; Retinal Degeneration | 1962 |
The EOG in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Autoimmune Diseases; Chloroquine; Electrooculography; Female; Humans; H | 1983 |
Chloroquine-induced lipidosis in the rat retina: a functional and morphological study.
Topics: Animals; Chloroquine; Electroretinography; Female; Lipidoses; Rats; Rats, Wistar; Retina; Retinal De | 1995 |
Chloroquine-induced lipidosis in the rat retina: functional and morphological changes after withdrawal of the drug.
Topics: Animals; Antimalarials; Chloroquine; Electroretinography; Female; Lipidoses; Photoreceptor Cells; Ra | 1996 |
[Functional exploration of the perimacular and macular retinal region by means of flicker E.R.G. and the determination of perceptive fusion thresholds of an intermittent light (De Lange's curve)].
Topics: Adult; Chloroquine; Electroretinography; Ethambutol; Flicker Fusion; Humans; Macula Lutea; Methods; | 1975 |
[Neurolo-toxicological disorders and retinal pigmentary degeneration].
Topics: Chloroquine; Humans; Nervous System Diseases; Phenothiazines; Retinal Degeneration | 1978 |
[Studies on drug-induced retinal degeneration. Part 3. Long-term observation on chloroquine retinopathy (author's transl)].
Topics: Adult; Chloroquine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Retinal Degeneration; Visu | 1977 |
Retinal vascular changes in bull's eye maculopathy.
Topics: Chloroquine; Female; Fluorescein Angiography; Humans; Macular Degeneration; Middle Aged; Retinal Deg | 1976 |
[The "bull's eye" maculopathy (symptomatology)].
Topics: Chloroquine; Humans; Macular Degeneration; Retinal Degeneration | 1976 |
[Toxic macular injuries].
Topics: Animals; Cats; Chloroquine; Dogs; Humans; Macula Lutea; Macular Degeneration; Phenothiazines; Retina | 1975 |
[Differential diagnosis of the "bull's eye" macula].
Topics: Chloroquine; Diagnosis, Differential; Female; Humans; Macular Degeneration; Male; Retinal Degenerati | 1975 |
[Side effects of chloroquine therapy].
Topics: Adult; Arthritis, Rheumatoid; Chloroquine; Diagnosis, Differential; Electroretinography; Female; Hum | 1989 |
[Diagnostic importance of electro-oculography in various hereditary dystrophies of the chorioretina].
Topics: Chloroquine; Electrooculography; Electroretinography; Humans; Macula Lutea; Retinal Degeneration; Re | 1974 |
The Pickford-Nicolson anomaloscope as a test for acquired dyschromatopsias.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Cataract; Cataract Extraction; Child; Chloroquine; C | 1972 |
[Chloroquine retinopathy and unilateral sectoral pigmentary degeneration of the retina (author's transl)].
Topics: Chloroquine; Diagnosis, Differential; Electrooculography; Female; Fundus Oculi; Humans; Middle Aged; | 1973 |
[Secondary toxic tapetoretinal dystrophy of the retina caused by delagil intoxication].
Topics: Adult; Chloroquine; Humans; Lupus Erythematosus, Systemic; Male; Retinal Degeneration; Retinal Disea | 1974 |
Ring maculopathies mimicking chloroquine retinopathy.
Topics: Adult; Blindness; Child; Chloroquine; Diagnosis, Differential; Female; Fluorescein Angiography; Fluo | 1974 |
Electrodiagnosis in drug-induced disorders of the eye.
Topics: Adult; Animals; Chloroquine; Electrodiagnosis; Electrooculography; Electroretinography; Eye Diseases | 1967 |
[Studies on drug-induced retinal degeneration. I. Early stages of experimental chloroquine retinopathy].
Topics: Animals; Chloroquine; Microscopy, Electron; Rabbits; Retina; Retinal Degeneration; Spectrum Analysis | 1969 |
[Oculo-neuro-myopathic syndrome due to chloroquine intoxication].
Topics: Arthritis, Rheumatoid; Chloroquine; Female; Humans; Macula Lutea; Middle Aged; Neuromuscular Disease | 1969 |
[Retinal degeneration in 2 children following preventive antimalarial treatment of the mother during pregnancy].
Topics: Adolescent; Adult; Chloroquine; Female; Fetal Diseases; Humans; Malaria; Pregnancy; Pregnancy Compli | 1969 |
Constant amplitude electroretinography for the determination of retinal sensitivity in normal and abnormal subjects.
Topics: Adaptation, Ocular; Adolescent; Adult; Aged; Child; Chloroquine; Dark Adaptation; Electrodes; Electr | 1970 |
[Studies on drug-induced retinal degeneration. 2. Changes in fine structures of inner layers of the retina in experimental chloroquine retinopathy].
Topics: Animals; Chloroquine; Microscopy, Electron; Rabbits; Retinal Degeneration | 1970 |
A preliminary study of the effect of chloroquine on the rat retina.
Topics: Animals; Chloroquine; Cytoplasmic Granules; Microscopy, Electron; Phosphates; Rats; Retina; Retinal | 1970 |
Rhythmic wavelets of the positive off effect in the human electroretinogram.
Topics: Adaptation, Ocular; Adult; Amplifiers, Electronic; Child, Preschool; Chloroquine; Computers; Diabeti | 1971 |
[2 cases of ocular disorders due to a synthesized antimalarial].
Topics: Adolescent; Chloroquine; Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Retinal Degener | 1968 |