chloroquine has been researched along with Pyrexia in 99 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To establish the effects of chloroquine on kidney function we monitored renal parameters in age and sex matched control subjects and patients who presented with acute transient fever." | 7.70 | Chloroquine influences renal function in rural Zimbabweans with acute transient fever. ( Munjeri, O; Musabayane, CT; Musvibe, A; Osim, EE; Wenyika, J, 1999) |
| " In a cohort of pregnant women enrolled at first antenatal clinic visit in rural Malawi, we evaluated reported fever, determined parasitemia, and placed the women on antimalarial regimens containing chloroquine (CQ) or mefloquine (MQ)." | 7.69 | Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine. ( Breman, JG; Heymann, DL; Khoromana, CO; Slutsker, L; Steketee, RW; Wirima, JJ, 1996) |
| "vivax malaria was at least that of chloroquine." | 6.76 | Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial. ( Borghini-Fuhrer, I; Duparc, S; Fleckenstein, L; Poravuth, Y; Purnama, A; Pyae Phyo, A; Rao, BH; Rueangweerayut, R; Shin, CS; Socheat, D; Tjitra, E; Uthaisin, C; Valecha, N, 2011) |
| "Chloroquine was prescribed at 25 mg per kg body weight, and administered over 3 days to patients suffering from uncomplicated malaria." | 6.71 | [In vivo evaluation of chloroquine therapeutic efficacy in uncomplicated Plasmodium falciparum malaria in Central African Republic ine 1997 and 1998]. ( Barrau, K; Bergeri, I; Delmont, J; Madji, N; Namsenmo, A; Ndoyo, J; Zoguéreh, DD, 2003) |
| "Chloroquine was provided free of charge to all fever cases." | 5.35 | Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India. ( Das, LK; Jambulingam, P; Sadanandane, C, 2008) |
| "Chloroquine tablets were distributed by health workers belonging to the community." | 5.28 | [The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission]. ( Baudon, D; Carnevale, P; Hervy, JP; Legros, F; Robert, V; Roux, J, 1989) |
| "The study examined the efficacy of chloroquine (CQ), amodiaquine (AQ) and sulphadoxine-pyrimethamine (SP) for the treatment of uncomplicated Plasmodium falciparum malaria in Ghana." | 5.11 | A randomized comparative study of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Ghana. ( Amankwa, J; Ansah, NA; Ansah, P; Anto, F; Anyorigiya, T; Atuguba, F; Hodgson, A; Mumuni, G; Oduro, AR, 2005) |
| " Children with fever and >or=2000 asexual forms of Plasmodium falciparum/ micro L in a thick blood smear received chloroquine and were randomly assigned to receive zinc (20 mg/d for infants, 40 mg/d for older children) or placebo for 4 d." | 5.10 | Effect of zinc on the treatment of Plasmodium falciparum malaria in children: a randomized controlled trial. ( , 2002) |
| "A 25 year old man was rushed to the emergency department when he was found unconscious in his room after taking two chloroquine tablets (600 mg base) for fever prescribed by local practitioner." | 3.78 | Acute life-threatening methaemoglobinaemia following ingestion of chloroquine. ( Abdali, N; Asif, MS; Rizvi, I; Zaidi, N; Zaman, S, 2012) |
| "This study showed that, home treatment with chloroquine significantly impacts on the outcome of severe malaria." | 3.74 | Early home treatment of childhood fevers with ineffective antimalarials is deleterious in the outcome of severe malaria. ( Amodu, OK; Olumese, PE; Omotade, OO; Orimadegun, AE, 2008) |
| "We have previously shown that both chloroquine and paracetamol (acetaminophen) have antipyretic activity during treatment of acute uncomplicated Plasmodium falciparum malaria in children 1-4 years old." | 3.73 | Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. ( Björkman, A; Hugosson, E; Montgomery, SM; Premji, Z; Troye-Blomberg, M, 2006) |
| " Of the antimalarial treatments given at home, 91% were started by the second day of fever and 92% were with chloroquine, the nationally recommended antimalarial at the time." | 3.71 | Malaria control in Bungoma District, Kenya: a survey of home treatment of children with fever, bednet use and attendance at antenatal clinics. ( Deming, MS; Hamel, MJ; Odhacha, A; Roberts, JM, 2001) |
| " The aim was to provide a baseline understanding of illness behaviour on which to build a programme for the promotion of prepackaged chloroquine and cotrimoxazole for early and appropriate treatment of childhood fevers at the community level." | 3.71 | Treatment of childhood fevers and other illnesses in three rural Nigerian communities. ( Adeneye, AK; Afolabi, BM; Agomo, PU; Akinlade, CO; Asa, S; Brieger, WR; Nwankwo, BO; Salako, LA; Umeh, RE, 2001) |
| " At present, under the National guidelines; all fevers are presumed to be due to malaria and chloroquine is given as presumptive treatment." | 3.70 | Clinical case definition of malaria at a secondary level hospital in northern India. ( Anand, K; Kant, S; Kapoor, SK; Kumar, G, 1999) |
| " We evaluated the training by measuring changes in the proportions of drug sales where an adequate amount of chloroquine was purchased and in the percentage of home-treated childhood fevers given an adequate amount of chloroquine." | 3.70 | Changing home treatment of childhood fevers by training shop keepers in rural Kenya. ( Haaland, A; Marsh, K; Marsh, VM; Mutemi, WM; Muturi, J; Otieno, G; Watkins, WM, 1999) |
| "To establish the effects of chloroquine on kidney function we monitored renal parameters in age and sex matched control subjects and patients who presented with acute transient fever." | 3.70 | Chloroquine influences renal function in rural Zimbabweans with acute transient fever. ( Munjeri, O; Musabayane, CT; Musvibe, A; Osim, EE; Wenyika, J, 1999) |
| "The efficacity of oral chloroquine was assessed in 360 out-clinic patients with symptomatic Plasmodium falciparum malaria who were enrolled at five sites, in four administrative regions of Senegal, between 1991 and 1995." | 3.69 | [In vivo chemosensitivity tests of Plasmodium falciparum to chloroquine in Senegal: the development of resistance and the assessment of therapeutic efficacy]. ( Molez, JF; Ndiaye, P; Sane, B; Sokhna, CS; Trape, JF, 1997) |
| " In a cohort of pregnant women enrolled at first antenatal clinic visit in rural Malawi, we evaluated reported fever, determined parasitemia, and placed the women on antimalarial regimens containing chloroquine (CQ) or mefloquine (MQ)." | 3.69 | Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine. ( Breman, JG; Heymann, DL; Khoromana, CO; Slutsker, L; Steketee, RW; Wirima, JJ, 1996) |
| " The children had persistent fever (5 or more days) despite treatment with chloroquine and were admitted to the Department of Child Health of the University of Ghana Medical School in Accra with severe malaria (Plasmodium falciparum)." | 3.69 | Persistent fever in severe malaria in children. ( Agyepong, I; Commey, J; Quarm-Goka, B, 1994) |
| "A village-based programme of presumptive treatment of fever, using voluntary village aides to dispense oral chloroquine or amodiaquine, was established in 1982 by the Papua New Guinea Institute of Medical Research (PNG IMR) in 35 rural villages or hamlets near Madang, on the north coast of PNG." | 3.67 | The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health. ( Alpers, MP; Heywood, PF; Jolley, DJ; Moir, JS; Tulloch, JL; Vrbova, H, 1985) |
| "A safe and reproducible Plasmodium vivax infectious challenge method is required to evaluate the efficacy of malaria vaccine candidates." | 2.76 | Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers. ( Arévalo-Herrera, M; Echavarría, JF; Epstein, JE; Herrera, S; Jordán-Villegas, A; Palacios, R; Ramírez, O; Richie, TL; Rocha, L; Solarte, Y; Vélez, JD, 2011) |
| "vivax malaria was at least that of chloroquine." | 2.76 | Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial. ( Borghini-Fuhrer, I; Duparc, S; Fleckenstein, L; Poravuth, Y; Purnama, A; Pyae Phyo, A; Rao, BH; Rueangweerayut, R; Shin, CS; Socheat, D; Tjitra, E; Uthaisin, C; Valecha, N, 2011) |
| "Self-reported CQ treatment of fever episodes at home as well as referrals to health centres increased over the study period." | 2.73 | Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial. ( Becher, H; Coulibaly, B; Eriksen, J; Gustafsson, L; Jahn, A; Kouyaté, B; Mueller, O; Sauerborn, R; Somé, F; Tomson, G, 2008) |
| "5% improvement in the accumulated proportion of patients (1) treated, (2) treated within 24h of illness onset, (3) treated with the recommended antimalarials, (4) treated at an adequate dosage and (5) treated for the correct duration." | 2.73 | Home-based management of fever and malaria treatment practices in Uganda. ( Nsungwa-Sabiiti, J; Ogwal-Okeng, J; Pariyo, G; Peterson, S; Petzold, MG; Tomson, G, 2007) |
| "Chloroquine was prescribed at 25 mg per kg body weight, and administered over 3 days to patients suffering from uncomplicated malaria." | 2.71 | [In vivo evaluation of chloroquine therapeutic efficacy in uncomplicated Plasmodium falciparum malaria in Central African Republic ine 1997 and 1998]. ( Barrau, K; Bergeri, I; Delmont, J; Madji, N; Namsenmo, A; Ndoyo, J; Zoguéreh, DD, 2003) |
| "Children with deep coma (scoring 0-2) had significantly longer duration of coma before presentation (P = 0." | 2.68 | Predictors of severity of illness on presentation in children with cerebral malaria. ( Biemba, G; Gordeuk, VR; Khumalo, H; Mabeza, GF; Moyo, VM; Nyarugwe, P; Parry, D; Thuma, PE; Zulu, S, 1995) |
| "The efficacy and toxicity of oral quinine combined with oral chloroquine were studied in 50 Thai men with uncomplicated falciparum malaria." | 2.68 | Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria. ( Chantra, A; Chindanond, D; Clemens, R; Phophak, N; Pukrittayakamee, S; Vanijanonta, S, 1996) |
| "Cases of human babesiosis are rarely reported and probably under-diagnosed in China; therefore, improving our understanding of this disease as a newly emerging public health threat is imperative." | 1.48 | Human babesiosis in Southeast China: A case report. ( Chen, H; Huang, S; Jin, L; Li, J; Ni, Q; Pan, C; Yao, L; Zhang, L, 2018) |
| "We report a case of dual infection of scrub typhus and malaria in a 48-year-old woman." | 1.40 | Scrub typhus and malaria co-infection causing severe sepsis. ( Kaushik, M; Mahajan, SK; Raina, R; Thakur, P, 2014) |
| "Chloroquine was provided free of charge to all fever cases." | 1.35 | Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India. ( Das, LK; Jambulingam, P; Sadanandane, C, 2008) |
| " Antimalarial drug dosage was incorrect in 84% of those who initiated self-treatment." | 1.33 | [Self-treatment of fever in the northern district of Dakar, Senegal]. ( Diedhiou, A; Juergens-Behr, A; Lemort, JP; Ndiaye, P; Tal-Dia, A, 2006) |
| "Chloroquine was initiated for therapy and the patient was successfully treated." | 1.33 | [A transfusion-transmitted malaria case]. ( Altoparlak, U; Erol, S; Kadanali, A; Ozkurt, Z; Taşyaran, MA, 2005) |
| "Quinine is the drug of choice for the treatment of cerebral malaria 87." | 1.32 | Assessment of doctors' management of severe malaria in urban centres in Eastern Nigeria. ( Ele, PU; Ibeh, CC; Ukpabi, OJ, 2004) |
| "Chloroquine resistance was seen in 23% of the cases." | 1.32 | Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal community. ( Chand, SK; Mishra, AK; Shukla, MM; Singh, N, 2003) |
| "Most children with symptoms of convulsions are taken to the health center, but are more likely than children with simple malaria to receive traditional treatments as well." | 1.31 | Patterns of care for childhood malaria in Zambia. ( Baume, C; Helitzer, D; Kachur, SP, 2000) |
| "Malaria is the primary diagnostic consideration in any child recently returning from an endemic area who presents with fever." | 1.28 | Malaria in children. ( Newman, J; Pender, E, 1990) |
| " Based on children's weights and treatment histories provided by their mothers, the median total dosage of chloroquine given at home was 12." | 1.28 | Home treatment of febrile children with antimalarial drugs in Togo. ( Deming, MS; Gayibor, A; Jones, TS; Karsa, T; Murphy, K, 1989) |
| "Chloroquine tablets were distributed by health workers belonging to the community." | 1.28 | [The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission]. ( Baudon, D; Carnevale, P; Hervy, JP; Legros, F; Robert, V; Roux, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (29.29) | 18.7374 |
| 1990's | 17 (17.17) | 18.2507 |
| 2000's | 34 (34.34) | 29.6817 |
| 2010's | 17 (17.17) | 24.3611 |
| 2020's | 2 (2.02) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, G | 1 |
| Wang, A | 1 |
| Wang, S | 1 |
| Qian, F | 1 |
| Chen, M | 1 |
| Yu, F | 1 |
| Zhang, J | 1 |
| Wang, X | 1 |
| Ma, X | 1 |
| Zhao, T | 1 |
| Zhang, F | 1 |
| Chen, Z | 1 |
| Matangila, JR | 1 |
| Nyembu, RK | 1 |
| Telo, GM | 1 |
| Ngoy, CD | 1 |
| Sakobo, TM | 1 |
| Massolo, JM | 1 |
| Muyembe, BM | 1 |
| Mvwala, RK | 1 |
| Ilunga, CK | 1 |
| Limbole, EB | 1 |
| Ntalaja, JM | 1 |
| Kongo, RM | 1 |
| Gunawardena, S | 1 |
| Daniels, RF | 1 |
| Yahathugoda, TC | 1 |
| Weerasooriya, MV | 1 |
| Durfee, K | 1 |
| Volkman, SK | 1 |
| Wirth, DF | 1 |
| Karunaweera, ND | 1 |
| Huang, S | 1 |
| Zhang, L | 1 |
| Yao, L | 1 |
| Li, J | 1 |
| Chen, H | 1 |
| Ni, Q | 1 |
| Pan, C | 1 |
| Jin, L | 1 |
| Redditt, V | 1 |
| Bogoch, I | 1 |
| Rashid, M | 1 |
| Mansanguan, C | 1 |
| Phumratanaprapin, W | 1 |
| Frauchiger, B | 1 |
| Koch, D | 1 |
| Gaehler, A | 1 |
| Blum, J | 1 |
| Lurà, M | 1 |
| Kaiser, D | 1 |
| Buettcher, M | 1 |
| García-Gil, R | 1 |
| Feliciano-Sanchez, A | 1 |
| García-Gil, M | 1 |
| Mahajan, SK | 1 |
| Kaushik, M | 1 |
| Raina, R | 1 |
| Thakur, P | 1 |
| Fegan, D | 1 |
| Glennon, MJ | 1 |
| Redig, AJ | 1 |
| Vaidya, A | 1 |
| Price, C | 2 |
| Katz, JT | 1 |
| Maguire, JH | 1 |
| Ashbaugh, C | 1 |
| Miller, AL | 1 |
| Loscalzo, J | 1 |
| Philip, KE | 1 |
| Baddeley, R | 1 |
| Jenkins, M | 1 |
| Bovill, B | 1 |
| Bouaziz, A | 1 |
| Jouault, C | 1 |
| Danquigny, AL | 1 |
| Blanc-Pattin, V | 1 |
| Rivoire, B | 1 |
| Badet, F | 1 |
| Vallet, H | 1 |
| Orimadegun, AE | 1 |
| Amodu, OK | 1 |
| Olumese, PE | 1 |
| Omotade, OO | 1 |
| Hildenwall, H | 1 |
| Lindkvist, J | 1 |
| Tumwine, JK | 1 |
| Bergqvist, Y | 1 |
| Pariyo, G | 3 |
| Tomson, G | 4 |
| Peterson, S | 3 |
| Poravuth, Y | 1 |
| Socheat, D | 1 |
| Rueangweerayut, R | 1 |
| Uthaisin, C | 1 |
| Pyae Phyo, A | 1 |
| Valecha, N | 2 |
| Rao, BH | 1 |
| Tjitra, E | 1 |
| Purnama, A | 1 |
| Borghini-Fuhrer, I | 1 |
| Duparc, S | 1 |
| Shin, CS | 1 |
| Fleckenstein, L | 1 |
| Herrera, S | 1 |
| Solarte, Y | 1 |
| Jordán-Villegas, A | 1 |
| Echavarría, JF | 1 |
| Rocha, L | 1 |
| Palacios, R | 1 |
| Ramírez, O | 1 |
| Vélez, JD | 1 |
| Epstein, JE | 1 |
| Richie, TL | 1 |
| Arévalo-Herrera, M | 1 |
| Zaki, SA | 1 |
| Shanbag, P | 1 |
| Rizvi, I | 1 |
| Zaman, S | 1 |
| Zaidi, N | 1 |
| Asif, MS | 1 |
| Abdali, N | 1 |
| Liang, SY | 1 |
| Westblade, LF | 1 |
| Mehrtens, J | 1 |
| Burnham, CA | 1 |
| Kuhlmann, FM | 1 |
| Sirima, SB | 1 |
| Konaté, A | 1 |
| Tiono, AB | 1 |
| Convelbo, N | 1 |
| Cousens, S | 1 |
| Pagnoni, F | 1 |
| Fernando, SD | 1 |
| Wickremasinghe, AR | 1 |
| Bergeri, I | 1 |
| Zoguéreh, DD | 1 |
| Madji, N | 1 |
| Barrau, K | 1 |
| Delmont, J | 1 |
| Namsenmo, A | 1 |
| Ndoyo, J | 1 |
| Singh, N | 2 |
| Mishra, AK | 1 |
| Shukla, MM | 1 |
| Chand, SK | 2 |
| Bouyou-Akotet, MK | 1 |
| Ionete-Collard, DE | 1 |
| Mabika-Manfoumbi, M | 1 |
| Kendjo, E | 1 |
| Matsiegui, PB | 1 |
| Mavoungou, E | 1 |
| Kombila, M | 1 |
| Ibeh, CC | 1 |
| Ele, PU | 1 |
| Ukpabi, OJ | 1 |
| Daga, SR | 1 |
| Patil, VB | 1 |
| Verma, B | 1 |
| Oduro, AR | 1 |
| Anyorigiya, T | 1 |
| Hodgson, A | 1 |
| Ansah, P | 1 |
| Anto, F | 1 |
| Ansah, NA | 1 |
| Atuguba, F | 1 |
| Mumuni, G | 1 |
| Amankwa, J | 1 |
| Ozkurt, Z | 1 |
| Erol, S | 1 |
| Kadanali, A | 1 |
| Altoparlak, U | 1 |
| Taşyaran, MA | 1 |
| Boecken, GH | 1 |
| Bronnert, J | 1 |
| Chapoy, P | 1 |
| Vovan, L | 1 |
| Theveniau, D | 1 |
| Garnier, JM | 1 |
| Perrimond, H | 1 |
| Louchet, E | 1 |
| Sowunmi, A | 2 |
| Fehintola, FA | 2 |
| Adedeji, AA | 2 |
| Gbotosho, GO | 1 |
| Tambo, E | 1 |
| Fateye, BA | 1 |
| Happi, TC | 1 |
| Oduola, AM | 2 |
| Ndiaye, P | 2 |
| Tal-Dia, A | 1 |
| Diedhiou, A | 1 |
| Juergens-Behr, A | 1 |
| Lemort, JP | 1 |
| Hugosson, E | 1 |
| Montgomery, SM | 1 |
| Premji, Z | 1 |
| Troye-Blomberg, M | 1 |
| Björkman, A | 1 |
| Nsabagasani, X | 1 |
| Källander, K | 1 |
| Conteh, L | 1 |
| Stevens, W | 1 |
| Wiseman, V | 1 |
| Taubitz, W | 1 |
| Cramer, JP | 1 |
| Kapaun, A | 1 |
| Pfeffer, M | 1 |
| Drosten, C | 1 |
| Dobler, G | 1 |
| Burchard, GD | 1 |
| Löscher, T | 1 |
| Nsungwa-Sabiiti, J | 1 |
| Ogwal-Okeng, J | 1 |
| Petzold, MG | 1 |
| Nahum, A | 1 |
| Erhart, A | 1 |
| Gazard, D | 1 |
| Agbowai, C | 1 |
| Van Overmeir, C | 1 |
| van Loen, H | 1 |
| Menten, J | 1 |
| Akogbeto, M | 1 |
| Coosemans, M | 1 |
| Massougbodji, A | 1 |
| D'Alessandro, U | 1 |
| Kouyaté, B | 1 |
| Somé, F | 1 |
| Jahn, A | 1 |
| Coulibaly, B | 1 |
| Eriksen, J | 1 |
| Sauerborn, R | 1 |
| Gustafsson, L | 1 |
| Becher, H | 1 |
| Mueller, O | 1 |
| Das, LK | 1 |
| Jambulingam, P | 1 |
| Sadanandane, C | 1 |
| Pazzaglia, G | 1 |
| Woodward, WE | 1 |
| Mabeza, GF | 1 |
| Moyo, VM | 1 |
| Thuma, PE | 1 |
| Biemba, G | 1 |
| Parry, D | 1 |
| Khumalo, H | 1 |
| Nyarugwe, P | 1 |
| Zulu, S | 1 |
| Gordeuk, VR | 1 |
| Commey, J | 1 |
| Quarm-Goka, B | 1 |
| Agyepong, I | 1 |
| Slutsker, L | 2 |
| Chitsulo, L | 1 |
| Macheso, A | 1 |
| Steketee, RW | 2 |
| Raharimalala, L | 1 |
| Lepers, JP | 1 |
| Lepers-Rason, MD | 1 |
| Rabarison, P | 1 |
| Ramambanirina, L | 1 |
| Roux, J | 2 |
| Barnish, G | 1 |
| Maude, GH | 1 |
| Bockarie, MJ | 1 |
| Eggelte, TA | 2 |
| Greenwood, BM | 1 |
| Mukherjee, H | 1 |
| Hati, AK | 1 |
| Wirima, JJ | 1 |
| Khoromana, CO | 1 |
| Heymann, DL | 1 |
| Breman, JG | 1 |
| Vanijanonta, S | 1 |
| Chantra, A | 1 |
| Phophak, N | 1 |
| Chindanond, D | 1 |
| Clemens, R | 1 |
| Pukrittayakamee, S | 1 |
| Sokhna, CS | 1 |
| Molez, JF | 1 |
| Sane, B | 1 |
| Trape, JF | 1 |
| Saxena, A | 1 |
| Sharma, VP | 1 |
| Musabayane, CT | 1 |
| Musvibe, A | 1 |
| Wenyika, J | 1 |
| Munjeri, O | 1 |
| Osim, EE | 1 |
| Novitzky, N | 1 |
| Marsh, VM | 1 |
| Mutemi, WM | 1 |
| Muturi, J | 1 |
| Haaland, A | 1 |
| Watkins, WM | 2 |
| Otieno, G | 1 |
| Marsh, K | 1 |
| Barat, L | 1 |
| Chipipa, J | 1 |
| Kolczak, M | 1 |
| Sukwa, T | 1 |
| Verhoef, H | 1 |
| Hodgins, E | 1 |
| Carter, JY | 1 |
| Lema, O | 1 |
| West, CE | 1 |
| Kok, FJ | 1 |
| Viraraghavan, R | 1 |
| Jantausch, B | 1 |
| Anand, K | 1 |
| Kant, S | 1 |
| Kumar, G | 1 |
| Kapoor, SK | 1 |
| Rashed, S | 2 |
| Johnson, H | 2 |
| Dongier, P | 2 |
| Moreau, R | 2 |
| Lee, C | 2 |
| Lambert, J | 2 |
| Schaefer, C | 2 |
| Falade, AG | 1 |
| Falade, CO | 1 |
| Akinyinka, OO | 1 |
| Baume, C | 1 |
| Helitzer, D | 1 |
| Kachur, SP | 1 |
| Nandi, J | 1 |
| Sharma, SN | 1 |
| Salako, LA | 1 |
| Brieger, WR | 1 |
| Afolabi, BM | 1 |
| Umeh, RE | 1 |
| Agomo, PU | 1 |
| Asa, S | 1 |
| Adeneye, AK | 1 |
| Nwankwo, BO | 1 |
| Akinlade, CO | 1 |
| Hamel, MJ | 1 |
| Odhacha, A | 1 |
| Roberts, JM | 1 |
| Deming, MS | 2 |
| Gong, XS | 1 |
| Talani, P | 1 |
| Samba, G | 1 |
| Moyen, G | 1 |
| Tarimo, DS | 1 |
| Minjas, JN | 1 |
| Bygbjerg, IC | 1 |
| Schultz, MG | 1 |
| Sauerwein, HP | 1 |
| DeBenedetti, C | 1 |
| Berner, H | 1 |
| Pender, E | 1 |
| Newman, J | 1 |
| Gayibor, A | 1 |
| Murphy, K | 1 |
| Jones, TS | 1 |
| Karsa, T | 1 |
| Aboff, BM | 1 |
| Robert, V | 1 |
| Hervy, JP | 1 |
| Baudon, D | 1 |
| Legros, F | 1 |
| Carnevale, P | 1 |
| McGlone, R | 1 |
| Mulik, R | 1 |
| Brandling-Bennett, AD | 1 |
| Oloo, AJ | 1 |
| Boriga, DA | 1 |
| Kariuki, DM | 1 |
| Collins, WE | 1 |
| Moir, JS | 2 |
| Tulloch, JL | 2 |
| Vrbova, H | 2 |
| Jolley, DJ | 2 |
| Heywood, PF | 2 |
| Alpers, MP | 2 |
| Metcalfe, P | 1 |
| Minchinton, RM | 1 |
| Murphy, MF | 1 |
| Waters, AH | 1 |
| Frame, JD | 1 |
| Baldwin, JM | 1 |
| Gocke, DJ | 1 |
| Troup, JM | 1 |
| Calabro, JJ | 1 |
| Katz, RM | 1 |
| Maltz, BA | 1 |
| Ayitey-Smith, E | 1 |
| Boye, GL | 1 |
| Nichani, N | 1 |
| Lewis, RA | 1 |
| Seeler, RA | 1 |
| Miller, RA | 1 |
| Lin, CH | 1 |
| Lin, SK | 1 |
| Geddes, AM | 1 |
| Powell, RJ | 1 |
| Lapierre, J | 1 |
| Holler, C | 1 |
| Berman, SJ | 1 |
| Walker, AJ | 1 |
| Lopez-Antunano, FJ | 1 |
| Sheehy, TW | 1 |
| Reba, RC | 1 |
| Parks, GR | 1 |
| Powell, RD | 1 |
| McNamara, JV | 1 |
| Patel, CC | 1 |
| Olurin, O | 1 |
| Stanfield, JP | 1 |
| Misra, SS | 1 |
| Sircar, AR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase III Comparative (Double-blind, Double-dummy) Randomised Multicentre Study to Assess the Safety & Efficacy of Oral Pyronaridine Artesunate (180:60 mg) Versus Chloroquine (155 mg) in Children & Adult Patients With Acute Vivax Malaria[NCT00440999] | Phase 3 | 456 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Comparison of the Susceptibility of Naive and Pre-immune Volunteers to Infectious Challenge With Viable Plasmodium Vivax Sporozoites.[NCT01585077] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| Evaluation of the Protective Efficacy of a Vaccine Derived From the Synthetic CS Protein of Plasmodium Vivax[NCT02083068] | Phase 2 | 32 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya[NCT02281123] | 200 participants (Anticipated) | Observational | 2014-07-31 | Active, not recruiting | |||
| A Comparative Study of Mefloquine and Sulphadoxine-pyrimethamine as Prophylaxis Against Malaria in Pregnant Human Immunodeficiency Virus Positive Patients[NCT02524444] | Phase 1 | 142 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Phase 1 and Phase 2a Clinical Trial:Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites[NCT01082341] | Phase 1/Phase 2 | 27 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Evaluation of Reproducibility of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers[NCT00367380] | Phase 2 | 18 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Fever clearance time is defined as the time from first dosing to the first normal reading of temperature (<37.5°C for axillary/tympanic or <38°C for oral/rectal) for 2 consecutive normal temperature readings taken between 7 and 25 hours apart. (NCT00440999)
Timeframe: Days 0 to 42
| Intervention | hours (Median) |
|---|---|
| Pyronaridine Artesunate | 15.8 |
| Chloroquine | 23.8 |
Parasite clearance time is defined as the time from first dosing to the time of first blood draw with parasite clearance. Parasite clearance is defined as zero presence of asexual parasites for 2 consecutive negative readings taken between 7 and 25 hours apart. (NCT00440999)
Timeframe: Days 0 to 42
| Intervention | hours (Median) |
|---|---|
| Pyronaridine Artesunate | 23.1 |
| Chloroquine | 32.0 |
Cure rate on Day 14 is defined as the absence of P. vivax parasitaemia on Day 14 irrespective of temperature (axillary, oral, tympanic, rectal) without previously meeting any of the criteria of treatment failure throughout the follow-up period. (NCT00440999)
Timeframe: Day 14
| Intervention | Participants (Count of Participants) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total cured | Cambodia | India | Indonesia/Maumere | Thailand/Mae Sot | Thailand/Mae Ramat | baseline P. vivax = 250-5,000/uL | baseline P. vivax = >5,000/uL-10,000/uL | baseline P. vivax = >10,000/uL | age ≤ 12 years | age ≥ 12 years | Gender - Male | Gender - Female | Previous P. vivax episode in the past = no | Previous P. vivax episode in the past = yes | |
| Chloroquine | 209 | 73 | 33 | 10 | 46 | 47 | 80 | 59 | 70 | 11 | 198 | 148 | 61 | 93 | 116 |
| Pyronaridine Artesunate | 217 | 75 | 33 | 11 | 49 | 50 | 69 | 58 | 89 | 13 | 204 | 164 | 53 | 107 | 110 |
Cure on Day 21 and 28 is defined as the absence of P. vivax parasitaemia on Day 21 and 28 irrespective of temperature (axillary, oral, tympanic, rectal) without previously meeting any of the criteria of treatment failure throughout the follow-up period. (NCT00440999)
Timeframe: Day 21 and 28
| Intervention | percentage of cured subjects (Number) | |
|---|---|---|
| Cure rate (%) at Day 21 | Cure rate (%) at Day 28 | |
| Chloroquine | 99.5 | 98.0 |
| Pyronaridine Artesunate | 99.5 | 97.1 |
Number of participants with adverse events, including clinically significant laboratory results, ECG, vital signs or physical examination abnormalities. (NCT00440999)
Timeframe: Day 0 to 42. Subjects experiencing AEs at Day 42 were followed for up to 30 days after the end of study or resolution of the event, whichever was earlier
| Intervention | Participants (Count of Participants) | |||||||
|---|---|---|---|---|---|---|---|---|
| Nr subj. with ≥1 AE | Nr subj. with ≥1 treatment-related AE | Nr subj. with ≥1 SAE | Nr subj. with ≥1 treatment-related SAE | Nr subj. with ≥1 severe or life-threatening AE | Nr subj. with ≥1 AE leading to death | Nr subj. ≥1 AE leading to study drug discontinuation | Nr subj. with ≥1 AE leading to study withdrawal | |
| Chloroquine | 72 | 23 | 0 | 0 | 2 | 0 | 2 | 2 |
| Pyronaridine Artesunate | 92 | 27 | 2 | 0 | 0 | 0 | 0 | 0 |
Cure on Day 42 is defined as the absence of P. vivax parasitaemia on Day 42 irrespective of temperature (axillary, oral, tympanic, rectal) without previously meeting any of the criteria of treatment failure throughout the follow-up period. (NCT00440999)
Timeframe: Day 42
| Intervention | percentage of subjects (Number) | |
|---|---|---|
| Crude cure rate (%) | PCR-corrected cure rate (%) | |
| Chloroquine | 92.1 | 94.1 |
| Pyronaridine Artesunate | 95.5 | 95.0 |
Percentage of subjects with fever clearance on Day 1 (24 hours after first dose), Day 2 (48 hours after first dose), and Day 3 (72 hours after first dose). (NCT00440999)
Timeframe: Day 1, 2, and 3
| Intervention | percentage of subjects (Number) | ||
|---|---|---|---|
| Clearance rate (%) at Day 1 (24h after first dose) | Clearance rate (%) at Day 2 (48h after first dose) | Clearance rate (%) at Day 3 (72h after first dose) | |
| Chloroquine | 58.4 | 88.3 | 97.4 |
| Pyronaridine Artesunate | 78.6 | 89.9 | 97.0 |
Percentage of subjects with parasite clearance on Day 1 (24 hours after first dose), Day 2 (48 hours after first dose), and Day 3 (72 hours after first dose). (NCT00440999)
Timeframe: Days 1, 2, and 3
| Intervention | percentage of subjects (Number) | ||
|---|---|---|---|
| Clearance rate (%) at Day 1 (24h after first dose) | Clearance rate (%) at Day 2 (48h after first dose) | Clearance rate (%) at Day 3 (72h after first dose) | |
| Chloroquine | 30.6 | 88.0 | 96.7 |
| Pyronaridine Artesunate | 71.6 | 99.5 | 100.0 |
Cure on Days 14, 21, and 28 is defined as the absence of P. vivax parasitaemia on Days 14, 21, and 28 irrespective of temperature (axillary, oral, tympanic, rectal) without previously meeting any of the criteria of treatment failure throughout the follow-up period. (NCT00440999)
Timeframe: Day 14, 21, and 28
| Intervention | percentage of subjects (Number) | ||
|---|---|---|---|
| Cure rate (%) at Day 14 | Cure rate (%) at Day 21 | Cure rate (%) at Day 28 | |
| Chloroquine | 99.5 | 99.5 | 97.9 |
| Pyronaridine Artesunate | 100.0 | 100.0 | 98.1 |
Thick blood smear was performed to patients daily on days 7 to 23, and every other day until day 29. Any prove of P. vivax infection was considered positive and confirmed later by real time polymerase chain reaction (rPCR). (NCT00367380)
Timeframe: Twenty eight days
| Intervention | days (Mean) |
|---|---|
| Group 1 | 11 |
| Group 2 | 11 |
| Group 3 | 9 |
1 review available for chloroquine and Pyrexia
| Article | Year |
|---|---|
A critical reappraisal of juvenile rheumatoid arthritis.
Topics: Agammaglobulinemia; Arthritis, Juvenile; Aspirin; Cardiomegaly; Child; Child, Preschool; Chloroquine | 1971 |
13 trials available for chloroquine and Pyrexia
| Article | Year |
|---|---|
Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Do | 2011 |
Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.
Topics: Adult; Animals; Antimalarials; Chloroquine; Duffy Blood-Group System; Female; Fever; Humans; Malaria | 2011 |
Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.
Topics: Adult; Animals; Antimalarials; Chloroquine; Duffy Blood-Group System; Female; Fever; Humans; Malaria | 2011 |
Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.
Topics: Adult; Animals; Antimalarials; Chloroquine; Duffy Blood-Group System; Female; Fever; Humans; Malaria | 2011 |
Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.
Topics: Adult; Animals; Antimalarials; Chloroquine; Duffy Blood-Group System; Female; Fever; Humans; Malaria | 2011 |
Effect of zinc on the treatment of Plasmodium falciparum malaria in children: a randomized controlled trial.
Topics: Animals; Child, Preschool; Chloroquine; Double-Blind Method; Ecuador; Fever; Ghana; Hospitalization; | 2002 |
[In vivo evaluation of chloroquine therapeutic efficacy in uncomplicated Plasmodium falciparum malaria in Central African Republic ine 1997 and 1998].
Topics: Administration, Oral; Antimalarials; Central African Republic; Chloroquine; Drug Resistance; Endemic | 2003 |
A randomized comparative study of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Ghana.
Topics: Amodiaquine; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Female; Fever; Ghana; | 2005 |
Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug Com | 2005 |
Home-based management of fever and malaria treatment practices in Uganda.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Services; Drug Combinations; D | 2007 |
Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa.
Topics: Analysis of Variance; Anemia; Animals; Antimalarials; Artemisinins; Artesunate; Benin; Child, Presch | 2007 |
Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial.
Topics: Anemia; Animals; Burkina Faso; Child, Preschool; Chloroquine; Female; Fever; Humans; Infant; Malaria | 2008 |
Predictors of severity of illness on presentation in children with cerebral malaria.
Topics: Age of Onset; Anemia; Child, Preschool; Chloroquine; Coma; Double-Blind Method; Drug Resistance; Fem | 1995 |
Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antimalarials; Chloroquine; Drug Therapy, Combination; Fev | 1996 |
Comparative efficacy of chloroquine plus chlorpheniramine alone and in a sequential combination with sulfadoxine-pyrimethamine, for the treatment of acute, uncomplicated, falciparum malaria in children.
Topics: Animals; Antimalarials; Antipruritics; Child; Child, Preschool; Chloroquine; Chlorpheniramine; Drug | 2000 |
Sulfadoxine-pyrimethamine monotherapy in Tanzanian children gives rapid parasite clearance but slow fever clearance that is improved by chloroquine in combination therapy.
Topics: Acetaminophen; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Dru | 2002 |
85 other studies available for chloroquine and Pyrexia
| Article | Year |
|---|---|
Brief Report: Retrospective Evaluation on the Efficacy of Lopinavir/Ritonavir and Chloroquine to Treat Nonsevere COVID-19 Patients.
Topics: Adult; Antimalarials; Chloroquine; Chronic Disease; Coronavirus Infections; COVID-19; Drug Combinati | 2020 |
Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study.
Topics: Adult; Aged; Blood Coagulation; Chloroquine; Coinfection; Comorbidity; Cough; COVID-19; COVID-19 Dru | 2020 |
Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status.
Topics: Adult; Antimalarials; Chloroquine; Fever; Humans; Liberia; Malaria; Malaria, Vivax; Male; Molecular | 2017 |
Human babesiosis in Southeast China: A case report.
Topics: Administration, Intravenous; Anemia, Hemolytic; Anti-Bacterial Agents; Azithromycin; Babesiosis; C-R | 2018 |
A 38-year-old man with fever and a history of malaria.
Topics: Adult; Antimalarials; Chloroquine; Diagnosis, Differential; Fever; Humans; Malaria, Vivax; Male; Pri | 2018 |
Concomitant
Topics: Adult; Anti-Bacterial Agents; Antimalarials; Chloroquine; Coinfection; Female; Fever; Humans; Malari | 2018 |
Don't forget the past: A sleeping disease can be awakened.
Topics: Chloroquine; Emergency Service, Hospital; Emigration and Immigration; Eritrea; Female; Fever; Humans | 2019 |
Birth of the pharmaceutical specialty.
Topics: Antimalarials; Chloroquine; Drug Compounding; Drug Packaging; Fever; History, 19th Century; Spain; T | 2019 |
Scrub typhus and malaria co-infection causing severe sepsis.
Topics: Animals; Anti-Bacterial Agents; Azithromycin; Chloroquine; Coinfection; Doxycycline; Enzyme-Linked I | 2014 |
SLE and dental erosion: a lethal cocktail.
Topics: Adolescent; Anti-Inflammatory Agents; Antirheumatic Agents; Chloroquine; Female; Fever; Fruit; Human | 2014 |
Interactive medical case. A chilly fever.
Topics: Adult; Antimalarials; Chloroquine; Diagnosis, Differential; Fever; Humans; Life Cycle Stages; Malari | 2014 |
Clinical problem-solving. A chilly fever.
Topics: Adult; Antimalarials; Blood; Chloroquine; Circadian Rhythm; Diagnosis, Differential; Fever; Humans; | 2014 |
Fever in the returning traveller: the importance of sensitivity.
Topics: Adult; Antimalarials; Cameroon; Chloroquine; Diagnosis, Differential; Fever; Follow-Up Studies; Huma | 2015 |
[Fever and chills in an 85-year-old woman].
Topics: Aged, 80 and over; Anemia, Sideroblastic; Antimalarials; Chills; Chloroquine; Diagnosis, Differentia | 2016 |
Early home treatment of childhood fevers with ineffective antimalarials is deleterious in the outcome of severe malaria.
Topics: Age Factors; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Fever; Humans; Infant; Mal | 2008 |
Low validity of caretakers' reports on use of selected antimalarials and antibiotics in children with severe pneumonia at an urban hospital in Uganda.
Topics: Anti-Infective Agents; Antimalarials; Caregivers; Child, Preschool; Chloroquine; Cross-Sectional Stu | 2009 |
Plasmodium vivax malaria presenting with skin rash--a case report.
Topics: Antimalarials; Child; Chloroquine; Exanthema; Female; Fever; Histamine Antagonists; Humans; Malaria, | 2011 |
Acute life-threatening methaemoglobinaemia following ingestion of chloroquine.
Topics: Acute Disease; Adult; Antimalarials; Chloroquine; Diagnosis, Differential; Enzyme Inhibitors; Fever; | 2012 |
Fever in a 20-year-old returned traveler.
Topics: Antimalarials; Chloroquine; Female; Fever; Humans; Malaria; Plasmodium malariae; Travel; Treatment O | 2013 |
Early treatment of childhood fevers with pre-packaged antimalarial drugs in the home reduces severe malaria morbidity in Burkina Faso.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Aspirin; Burkina Faso; Child, Preschool; Chl | 2003 |
The clinical and epidemiological features of childhood malaria in a moderately endemic area of Sri Lanka.
Topics: Administration, Oral; Antimalarials; Arthralgia; Case-Control Studies; Child; Child Welfare; Child, | 2002 |
Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal community.
Topics: Adolescent; Adult; Age Factors; Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroqu | 2003 |
Prevalence of Plasmodium falciparum infection in pregnant women in Gabon.
Topics: Adolescent; Adult; Age Factors; Animals; Chloroquine; Female; Fever; Gabon; Gravidity; Hemoglobin, S | 2003 |
Assessment of doctors' management of severe malaria in urban centres in Eastern Nigeria.
Topics: Adult; Analgesics; Analgesics, Non-Narcotic; Anemia; Antimalarials; Blood Transfusion; Chloroquine; | 2004 |
Syndromic management of prolonged fever: a cost-effective approach.
Topics: Anti-Infective Agents; Antimalarials; Chloramphenicol; Chloroquine; Cost-Benefit Analysis; Drug Ther | 2005 |
[A transfusion-transmitted malaria case].
Topics: Animals; Antimalarials; Blood Donors; Chills; Chloroquine; Diarrhea; Female; Fever; Humans; Jaundice | 2005 |
Pathogenesis and management of a late manifestation of vivax malaria after deployment to Afghanistan: conclusions for NATO Armed Forces Medical Services.
Topics: Adult; Afghanistan; Anemia; Antimalarials; Chloroquine; Fever; Germany; Hospitals, Military; Humans; | 2005 |
[Malaria in childhood and G6PD deficiency. Report of three cases].
Topics: Adolescent; Antimalarials; Black People; Blood Transfusion; Child; Chloroquine; Comoros; Emergency T | 1978 |
[Self-treatment of fever in the northern district of Dakar, Senegal].
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Studies; Dru | 2006 |
Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Child, Preschool; Chloroquine; Cyto | 2006 |
Home-based management of fever in rural Uganda: community perceptions and provider opinions.
Topics: Adolescent; Adult; Antimalarials; Child, Preschool; Chloroquine; Community Health Services; Communit | 2007 |
The role of communication between clients and health care providers: implications for adherence to malaria treatment in rural Gambia.
Topics: Antimalarials; Attitude to Health; Child; Child, Preschool; Chloroquine; Communication Barriers; Dru | 2007 |
Chikungunya fever in travelers: clinical presentation and course.
Topics: Adolescent; Adult; Alphavirus Infections; Arthralgia; Chikungunya virus; Child; Chloroquine; Female; | 2007 |
Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Workers; | 2008 |
An analysis of the relationship of host factors to clinical falciparum malaria by multiple regression techniques.
Topics: Adult; Age Factors; Black People; Body Weight; Chloroquine; Clindamycin; Fever; Humans; Malaria; Mal | 1982 |
Persistent fever in severe malaria in children.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Chloroquine; Chronic Disease; Drug Resistance; Femal | 1994 |
Treatment of malaria fever episodes among children in Malawi: results of a KAP survey.
Topics: Algorithms; Ambulatory Care Facilities; Antimalarials; Caregivers; Child; Child, Preschool; Chloroqu | 1994 |
[Aspects of Plasmodium falciparum sensitivity to chloroquine in Madagascar from 1982 to 1993].
Topics: Animals; Chloroquine; Drug Resistance; Fever; Humans; Madagascar; Malaria, Falciparum; Plasmodium fa | 1993 |
The epidemiology of malaria in southern Sierra Leone.
Topics: Child; Child, Preschool; Chloroquine; Comorbidity; Cross-Sectional Studies; Female; Fever; Hematocri | 1993 |
Atypical postponing of fever in a case of vivax malaria.
Topics: Adult; Chloroquine; Fever; Humans; Malaria, Vivax; Male; Time Factors | 1995 |
Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Female; Fetal Death; Fever; Humans; Malaria, Falcipar | 1996 |
[In vivo chemosensitivity tests of Plasmodium falciparum to chloroquine in Senegal: the development of resistance and the assessment of therapeutic efficacy].
Topics: Administration, Oral; Adolescent; Adult; Aged; Ambulatory Care; Animals; Antimalarials; Bias; Chemop | 1997 |
Studies on malaria during pregnancy in a tribal area of central India (Madhya Pradesh).
Topics: Adult; Antimalarials; Chloroquine; Female; Fever; Hemoglobins; Humans; India; Malaria; Malaria, Falc | 1998 |
Chloroquine influences renal function in rural Zimbabweans with acute transient fever.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Blood Pressure; Chloroquin | 1999 |
A case of fever, confusion and anaemia in a young woman.
Topics: Adult; Anemia; Antimalarials; Chloroquine; Confusion; Drug Therapy, Combination; Female; Fever; Huma | 1999 |
Changing home treatment of childhood fevers by training shop keepers in rural Kenya.
Topics: Analgesics, Non-Narcotic; Antimalarials; Child; Chloroquine; Community Pharmacy Services; Drug Infor | 1999 |
Does the availability of blood slide microscopy for malaria at health centers improve the management of persons with fever in Zambia?
Topics: Ambulatory Care Facilities; Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations | 1999 |
Anti-malarial drug use among preschool children in an area of seasonal malaria transmission in Kenya.
Topics: Adult; Animals; Antibodies, Monoclonal; Antimalarials; Child, Preschool; Chloroquine; Cluster Analys | 1999 |
Congenital malaria: diagnosis and therapy.
Topics: Animals; Antimalarials; Chloroquine; District of Columbia; Female; Fever; Humans; Infant; Jaundice; | 2000 |
Clinical case definition of malaria at a secondary level hospital in northern India.
Topics: Analysis of Variance; Antimalarials; Case-Control Studies; Child; Chloroquine; Female; Fever; Humans | 1999 |
Economic impact of febrile morbidity and use of permethrin-impregnated bed-nets in a malarious area I. Study of demographics, morbidity, and household expenditures associated with febrile morbidity in the Republic of Benin.
Topics: Adult; Animals; Anopheles; Antimalarials; Attitude to Health; Bedding and Linens; Benin; Child, Pres | 2000 |
Economic impact of febrile morbidity and use of permethrin-impregnated bed nets in a malarious area II. Determinants of febrile episodes and the cost of their treatment and malaria prevention.
Topics: Adult; Animals; Anopheles; Antimalarials; Bedding and Linens; Benin; Child, Preschool; Chloroquine; | 2000 |
Patterns of care for childhood malaria in Zambia.
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Female; Fever; Health Care Surveys; | 2000 |
Efficacy of chloroquine in febrile Plasmodium falciparum infected children in Mewat region of Haryana.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Fever; Humans; Infant; Mal | 2000 |
Treatment of childhood fevers and other illnesses in three rural Nigerian communities.
Topics: Anti-Bacterial Agents; Antimalarials; Child; Child, Preschool; Chloroquine; Cough; Female; Fever; He | 2001 |
Malaria control in Bungoma District, Kenya: a survey of home treatment of children with fever, bednet use and attendance at antenatal clinics.
Topics: Antimalarials; Bedding and Linens; Child; Child Care; Chloroquine; Cluster Analysis; Communicable Di | 2001 |
Effective control of infection-associated hemophagocytic syndrome with chloroquine.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Fever; Histiocytosis, Non-L | 2002 |
[Management of child fever in the battle against malaria in Brazzaville].
Topics: Amodiaquine; Antimalarials; Asthenia; Child, Preschool; Chills; Chloroquine; Congo; Diarrhea; Fever; | 2002 |
Exotic diseases. Ounce of prevention or pound of cure?
Topics: Beverages; Chloroquine; Clioquinol; Diagnosis; Diarrhea; Drug Resistance, Microbial; Eosinophils; Fe | 1977 |
[A patient with high fever].
Topics: Chloroquine; Fever; Humans; Indonesia; Malaria; Male; Middle Aged; Netherlands; Nigeria; Plasmodium | 1977 |
Juvenile rheumatoid arthritis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Arthritis, Juvenile; Aspirin; | 1976 |
[Malaria in children, with special reference to cerebral malaria (author's transl)].
Topics: Age Factors; Anemia, Hemolytic; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; Chloroquine | 1975 |
Malaria in children.
Topics: Adolescent; Anemia; Animals; Child; Chloroquine; Diagnosis, Differential; Emergencies; Female; Fever | 1990 |
Home treatment of febrile children with antimalarial drugs in Togo.
Topics: Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Fever; Home Nursing; Humans; | 1989 |
Febrile illness in an Afghani "freedom fighter".
Topics: Administration, Oral; Adult; Afghanistan; Animals; Chloroquine; Emigration and Immigration; Fever; H | 1989 |
[The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission].
Topics: Adolescent; Animals; Anopheles; Burkina Faso; Child; Child, Preschool; Chloroquine; Dose-Response Re | 1989 |
Hypnozoites in Bradford.
Topics: Animals; Child, Preschool; Chloroquine; England; Fever; Humans; Infant, Newborn; Malaria; Male; Plas | 1988 |
Chloroquine treatment of falciparum malaria in an area of Kenya of intermediate chloroquine resistance.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Fever; Humans; Infant; Kenya; Malari | 1988 |
The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 1. Selection, training and practice.
Topics: Adult; Amodiaquine; Attitude to Health; Chloroquine; Community Health Workers; Female; Fever; Humans | 1985 |
The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health.
Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Community Health Workers; Fever; Huma | 1985 |
Use of chloroquine-treated granulocytes and platelets in the diagnosis of immune cytopenias.
Topics: Adult; Antibodies; Autoantibodies; Autoimmune Diseases; Blood Platelets; Chloroquine; Female; Fever; | 1985 |
Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings.
Topics: Acute Disease; Adult; Aged; Autopsy; Back Pain; Blood; Blood Cell Count; Chloroquine; Edema; Female; | 1970 |
Effect of hyperthermia on acute chloroquine toxicity in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Chloroquine; Electrocardiography; Female; Fever; Male | 1974 |
Transfusion-induced malaria. Plasmodium vivax in a 5-month-old child.
Topics: Chloroquine; Fever; Hemolysis; Hepatomegaly; Humans; Infant; Malaria; Male; Plasmodium vivax; Primaq | 1973 |
Imported infections. Unexplained fever.
Topics: Africa; Asia; Brucellosis; Chloramphenicol; Chloroquine; Fever; Humans; Leishmaniasis, Visceral; Liv | 1974 |
Systemic lupus erythematosus with widespread subcutaneous fat calcification.
Topics: Adipose Tissue; Adult; Calcinosis; Chloroquine; Female; Fever; Humans; Lupus Erythematosus, Systemic | 1974 |
[A febrile crisis of suspected malarial etiology in a person returning from the tropics].
Topics: Antimalarials; Blood; Chloroquine; Drug Synergism; Fever; Humans; Liver Function Tests; Malaria; Pla | 1974 |
Chloroquine-pyrimethamine-sulfisoxazole therapy of Plasmodium falciparum malaria. An alternative to quinine.
Topics: Chloroquine; Dapsone; Drug Resistance, Microbial; Fever; Humans; Malaria; Male; Military Medicine; P | 1969 |
Response to drugs of South American strains of Plasmodium falciparum.
Topics: Chloroquine; Drug Resistance, Microbial; Drug Synergism; Fever; Humans; Malaria; Plasmodium falcipar | 1968 |
Combined pyrimethamine-quinine therapy for chloroquine-resistant P. falciparum infections.
Topics: Adolescent; Adult; Agranulocytosis; Anemia, Hemolytic; Chloroquine; Clinical Laboratory Techniques; | 1969 |
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial | 1970 |
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial | 1970 |
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial | 1970 |
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial | 1970 |
Acute febrile encephalopathy in Ugandan children.
Topics: Cerebrospinal Fluid; Child; Child, Preschool; Chloroquine; Encephalitis; Female; Fever; Gastrointest | 1971 |
Cortical blindness following convulsions and fever in Nigerian children.
Topics: Anti-Bacterial Agents; Anticonvulsants; Blindness; Blood Transfusion; Bronchopneumonia; Cerebral Cor | 1970 |
Fever in children in the tropics.
Topics: Anti-Bacterial Agents; Aspirin; Child; Child, Preschool; Chloroquine; Fever; Humans; Hypothermia; Ph | 1969 |
Chloroquine therapy in pyrexia of unknown origin.
Topics: Adult; Chloroquine; Female; Fever; Humans; Male; Middle Aged | 1966 |