Page last updated: 2024-10-24

chloroquine and Pyrexia

chloroquine has been researched along with Pyrexia in 99 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Research Excerpts

ExcerptRelevanceReference
"To establish the effects of chloroquine on kidney function we monitored renal parameters in age and sex matched control subjects and patients who presented with acute transient fever."7.70Chloroquine influences renal function in rural Zimbabweans with acute transient fever. ( Munjeri, O; Musabayane, CT; Musvibe, A; Osim, EE; Wenyika, J, 1999)
" In a cohort of pregnant women enrolled at first antenatal clinic visit in rural Malawi, we evaluated reported fever, determined parasitemia, and placed the women on antimalarial regimens containing chloroquine (CQ) or mefloquine (MQ)."7.69Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine. ( Breman, JG; Heymann, DL; Khoromana, CO; Slutsker, L; Steketee, RW; Wirima, JJ, 1996)
"vivax malaria was at least that of chloroquine."6.76Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial. ( Borghini-Fuhrer, I; Duparc, S; Fleckenstein, L; Poravuth, Y; Purnama, A; Pyae Phyo, A; Rao, BH; Rueangweerayut, R; Shin, CS; Socheat, D; Tjitra, E; Uthaisin, C; Valecha, N, 2011)
"Chloroquine was prescribed at 25 mg per kg body weight, and administered over 3 days to patients suffering from uncomplicated malaria."6.71[In vivo evaluation of chloroquine therapeutic efficacy in uncomplicated Plasmodium falciparum malaria in Central African Republic ine 1997 and 1998]. ( Barrau, K; Bergeri, I; Delmont, J; Madji, N; Namsenmo, A; Ndoyo, J; Zoguéreh, DD, 2003)
"Chloroquine was provided free of charge to all fever cases."5.35Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India. ( Das, LK; Jambulingam, P; Sadanandane, C, 2008)
"Chloroquine tablets were distributed by health workers belonging to the community."5.28[The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission]. ( Baudon, D; Carnevale, P; Hervy, JP; Legros, F; Robert, V; Roux, J, 1989)
"The study examined the efficacy of chloroquine (CQ), amodiaquine (AQ) and sulphadoxine-pyrimethamine (SP) for the treatment of uncomplicated Plasmodium falciparum malaria in Ghana."5.11A randomized comparative study of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Ghana. ( Amankwa, J; Ansah, NA; Ansah, P; Anto, F; Anyorigiya, T; Atuguba, F; Hodgson, A; Mumuni, G; Oduro, AR, 2005)
" Children with fever and >or=2000 asexual forms of Plasmodium falciparum/ micro L in a thick blood smear received chloroquine and were randomly assigned to receive zinc (20 mg/d for infants, 40 mg/d for older children) or placebo for 4 d."5.10Effect of zinc on the treatment of Plasmodium falciparum malaria in children: a randomized controlled trial. ( , 2002)
"A 25 year old man was rushed to the emergency department when he was found unconscious in his room after taking two chloroquine tablets (600 mg base) for fever prescribed by local practitioner."3.78Acute life-threatening methaemoglobinaemia following ingestion of chloroquine. ( Abdali, N; Asif, MS; Rizvi, I; Zaidi, N; Zaman, S, 2012)
"This study showed that, home treatment with chloroquine significantly impacts on the outcome of severe malaria."3.74Early home treatment of childhood fevers with ineffective antimalarials is deleterious in the outcome of severe malaria. ( Amodu, OK; Olumese, PE; Omotade, OO; Orimadegun, AE, 2008)
"We have previously shown that both chloroquine and paracetamol (acetaminophen) have antipyretic activity during treatment of acute uncomplicated Plasmodium falciparum malaria in children 1-4 years old."3.73Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. ( Björkman, A; Hugosson, E; Montgomery, SM; Premji, Z; Troye-Blomberg, M, 2006)
" Of the antimalarial treatments given at home, 91% were started by the second day of fever and 92% were with chloroquine, the nationally recommended antimalarial at the time."3.71Malaria control in Bungoma District, Kenya: a survey of home treatment of children with fever, bednet use and attendance at antenatal clinics. ( Deming, MS; Hamel, MJ; Odhacha, A; Roberts, JM, 2001)
" The aim was to provide a baseline understanding of illness behaviour on which to build a programme for the promotion of prepackaged chloroquine and cotrimoxazole for early and appropriate treatment of childhood fevers at the community level."3.71Treatment of childhood fevers and other illnesses in three rural Nigerian communities. ( Adeneye, AK; Afolabi, BM; Agomo, PU; Akinlade, CO; Asa, S; Brieger, WR; Nwankwo, BO; Salako, LA; Umeh, RE, 2001)
" At present, under the National guidelines; all fevers are presumed to be due to malaria and chloroquine is given as presumptive treatment."3.70Clinical case definition of malaria at a secondary level hospital in northern India. ( Anand, K; Kant, S; Kapoor, SK; Kumar, G, 1999)
" We evaluated the training by measuring changes in the proportions of drug sales where an adequate amount of chloroquine was purchased and in the percentage of home-treated childhood fevers given an adequate amount of chloroquine."3.70Changing home treatment of childhood fevers by training shop keepers in rural Kenya. ( Haaland, A; Marsh, K; Marsh, VM; Mutemi, WM; Muturi, J; Otieno, G; Watkins, WM, 1999)
"To establish the effects of chloroquine on kidney function we monitored renal parameters in age and sex matched control subjects and patients who presented with acute transient fever."3.70Chloroquine influences renal function in rural Zimbabweans with acute transient fever. ( Munjeri, O; Musabayane, CT; Musvibe, A; Osim, EE; Wenyika, J, 1999)
"The efficacity of oral chloroquine was assessed in 360 out-clinic patients with symptomatic Plasmodium falciparum malaria who were enrolled at five sites, in four administrative regions of Senegal, between 1991 and 1995."3.69[In vivo chemosensitivity tests of Plasmodium falciparum to chloroquine in Senegal: the development of resistance and the assessment of therapeutic efficacy]. ( Molez, JF; Ndiaye, P; Sane, B; Sokhna, CS; Trape, JF, 1997)
" In a cohort of pregnant women enrolled at first antenatal clinic visit in rural Malawi, we evaluated reported fever, determined parasitemia, and placed the women on antimalarial regimens containing chloroquine (CQ) or mefloquine (MQ)."3.69Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine. ( Breman, JG; Heymann, DL; Khoromana, CO; Slutsker, L; Steketee, RW; Wirima, JJ, 1996)
" The children had persistent fever (5 or more days) despite treatment with chloroquine and were admitted to the Department of Child Health of the University of Ghana Medical School in Accra with severe malaria (Plasmodium falciparum)."3.69Persistent fever in severe malaria in children. ( Agyepong, I; Commey, J; Quarm-Goka, B, 1994)
"A village-based programme of presumptive treatment of fever, using voluntary village aides to dispense oral chloroquine or amodiaquine, was established in 1982 by the Papua New Guinea Institute of Medical Research (PNG IMR) in 35 rural villages or hamlets near Madang, on the north coast of PNG."3.67The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health. ( Alpers, MP; Heywood, PF; Jolley, DJ; Moir, JS; Tulloch, JL; Vrbova, H, 1985)
"A safe and reproducible Plasmodium vivax infectious challenge method is required to evaluate the efficacy of malaria vaccine candidates."2.76Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers. ( Arévalo-Herrera, M; Echavarría, JF; Epstein, JE; Herrera, S; Jordán-Villegas, A; Palacios, R; Ramírez, O; Richie, TL; Rocha, L; Solarte, Y; Vélez, JD, 2011)
"vivax malaria was at least that of chloroquine."2.76Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial. ( Borghini-Fuhrer, I; Duparc, S; Fleckenstein, L; Poravuth, Y; Purnama, A; Pyae Phyo, A; Rao, BH; Rueangweerayut, R; Shin, CS; Socheat, D; Tjitra, E; Uthaisin, C; Valecha, N, 2011)
"Self-reported CQ treatment of fever episodes at home as well as referrals to health centres increased over the study period."2.73Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial. ( Becher, H; Coulibaly, B; Eriksen, J; Gustafsson, L; Jahn, A; Kouyaté, B; Mueller, O; Sauerborn, R; Somé, F; Tomson, G, 2008)
"5% improvement in the accumulated proportion of patients (1) treated, (2) treated within 24h of illness onset, (3) treated with the recommended antimalarials, (4) treated at an adequate dosage and (5) treated for the correct duration."2.73Home-based management of fever and malaria treatment practices in Uganda. ( Nsungwa-Sabiiti, J; Ogwal-Okeng, J; Pariyo, G; Peterson, S; Petzold, MG; Tomson, G, 2007)
"Chloroquine was prescribed at 25 mg per kg body weight, and administered over 3 days to patients suffering from uncomplicated malaria."2.71[In vivo evaluation of chloroquine therapeutic efficacy in uncomplicated Plasmodium falciparum malaria in Central African Republic ine 1997 and 1998]. ( Barrau, K; Bergeri, I; Delmont, J; Madji, N; Namsenmo, A; Ndoyo, J; Zoguéreh, DD, 2003)
"Children with deep coma (scoring 0-2) had significantly longer duration of coma before presentation (P = 0."2.68Predictors of severity of illness on presentation in children with cerebral malaria. ( Biemba, G; Gordeuk, VR; Khumalo, H; Mabeza, GF; Moyo, VM; Nyarugwe, P; Parry, D; Thuma, PE; Zulu, S, 1995)
"The efficacy and toxicity of oral quinine combined with oral chloroquine were studied in 50 Thai men with uncomplicated falciparum malaria."2.68Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria. ( Chantra, A; Chindanond, D; Clemens, R; Phophak, N; Pukrittayakamee, S; Vanijanonta, S, 1996)
"Cases of human babesiosis are rarely reported and probably under-diagnosed in China; therefore, improving our understanding of this disease as a newly emerging public health threat is imperative."1.48Human babesiosis in Southeast China: A case report. ( Chen, H; Huang, S; Jin, L; Li, J; Ni, Q; Pan, C; Yao, L; Zhang, L, 2018)
"We report a case of dual infection of scrub typhus and malaria in a 48-year-old woman."1.40Scrub typhus and malaria co-infection causing severe sepsis. ( Kaushik, M; Mahajan, SK; Raina, R; Thakur, P, 2014)
"Chloroquine was provided free of charge to all fever cases."1.35Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India. ( Das, LK; Jambulingam, P; Sadanandane, C, 2008)
" Antimalarial drug dosage was incorrect in 84% of those who initiated self-treatment."1.33[Self-treatment of fever in the northern district of Dakar, Senegal]. ( Diedhiou, A; Juergens-Behr, A; Lemort, JP; Ndiaye, P; Tal-Dia, A, 2006)
"Chloroquine was initiated for therapy and the patient was successfully treated."1.33[A transfusion-transmitted malaria case]. ( Altoparlak, U; Erol, S; Kadanali, A; Ozkurt, Z; Taşyaran, MA, 2005)
"Quinine is the drug of choice for the treatment of cerebral malaria 87."1.32Assessment of doctors' management of severe malaria in urban centres in Eastern Nigeria. ( Ele, PU; Ibeh, CC; Ukpabi, OJ, 2004)
"Chloroquine resistance was seen in 23% of the cases."1.32Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal community. ( Chand, SK; Mishra, AK; Shukla, MM; Singh, N, 2003)
"Most children with symptoms of convulsions are taken to the health center, but are more likely than children with simple malaria to receive traditional treatments as well."1.31Patterns of care for childhood malaria in Zambia. ( Baume, C; Helitzer, D; Kachur, SP, 2000)
"Malaria is the primary diagnostic consideration in any child recently returning from an endemic area who presents with fever."1.28Malaria in children. ( Newman, J; Pender, E, 1990)
" Based on children's weights and treatment histories provided by their mothers, the median total dosage of chloroquine given at home was 12."1.28Home treatment of febrile children with antimalarial drugs in Togo. ( Deming, MS; Gayibor, A; Jones, TS; Karsa, T; Murphy, K, 1989)
"Chloroquine tablets were distributed by health workers belonging to the community."1.28[The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission]. ( Baudon, D; Carnevale, P; Hervy, JP; Legros, F; Robert, V; Roux, J, 1989)

Research

Studies (99)

TimeframeStudies, this research(%)All Research%
pre-199029 (29.29)18.7374
1990's17 (17.17)18.2507
2000's34 (34.34)29.6817
2010's17 (17.17)24.3611
2020's2 (2.02)2.80

Authors

AuthorsStudies
Gao, G1
Wang, A1
Wang, S1
Qian, F1
Chen, M1
Yu, F1
Zhang, J1
Wang, X1
Ma, X1
Zhao, T1
Zhang, F1
Chen, Z1
Matangila, JR1
Nyembu, RK1
Telo, GM1
Ngoy, CD1
Sakobo, TM1
Massolo, JM1
Muyembe, BM1
Mvwala, RK1
Ilunga, CK1
Limbole, EB1
Ntalaja, JM1
Kongo, RM1
Gunawardena, S1
Daniels, RF1
Yahathugoda, TC1
Weerasooriya, MV1
Durfee, K1
Volkman, SK1
Wirth, DF1
Karunaweera, ND1
Huang, S1
Zhang, L1
Yao, L1
Li, J1
Chen, H1
Ni, Q1
Pan, C1
Jin, L1
Redditt, V1
Bogoch, I1
Rashid, M1
Mansanguan, C1
Phumratanaprapin, W1
Frauchiger, B1
Koch, D1
Gaehler, A1
Blum, J1
Lurà, M1
Kaiser, D1
Buettcher, M1
García-Gil, R1
Feliciano-Sanchez, A1
García-Gil, M1
Mahajan, SK1
Kaushik, M1
Raina, R1
Thakur, P1
Fegan, D1
Glennon, MJ1
Redig, AJ1
Vaidya, A1
Price, C2
Katz, JT1
Maguire, JH1
Ashbaugh, C1
Miller, AL1
Loscalzo, J1
Philip, KE1
Baddeley, R1
Jenkins, M1
Bovill, B1
Bouaziz, A1
Jouault, C1
Danquigny, AL1
Blanc-Pattin, V1
Rivoire, B1
Badet, F1
Vallet, H1
Orimadegun, AE1
Amodu, OK1
Olumese, PE1
Omotade, OO1
Hildenwall, H1
Lindkvist, J1
Tumwine, JK1
Bergqvist, Y1
Pariyo, G3
Tomson, G4
Peterson, S3
Poravuth, Y1
Socheat, D1
Rueangweerayut, R1
Uthaisin, C1
Pyae Phyo, A1
Valecha, N2
Rao, BH1
Tjitra, E1
Purnama, A1
Borghini-Fuhrer, I1
Duparc, S1
Shin, CS1
Fleckenstein, L1
Herrera, S1
Solarte, Y1
Jordán-Villegas, A1
Echavarría, JF1
Rocha, L1
Palacios, R1
Ramírez, O1
Vélez, JD1
Epstein, JE1
Richie, TL1
Arévalo-Herrera, M1
Zaki, SA1
Shanbag, P1
Rizvi, I1
Zaman, S1
Zaidi, N1
Asif, MS1
Abdali, N1
Liang, SY1
Westblade, LF1
Mehrtens, J1
Burnham, CA1
Kuhlmann, FM1
Sirima, SB1
Konaté, A1
Tiono, AB1
Convelbo, N1
Cousens, S1
Pagnoni, F1
Fernando, SD1
Wickremasinghe, AR1
Bergeri, I1
Zoguéreh, DD1
Madji, N1
Barrau, K1
Delmont, J1
Namsenmo, A1
Ndoyo, J1
Singh, N2
Mishra, AK1
Shukla, MM1
Chand, SK2
Bouyou-Akotet, MK1
Ionete-Collard, DE1
Mabika-Manfoumbi, M1
Kendjo, E1
Matsiegui, PB1
Mavoungou, E1
Kombila, M1
Ibeh, CC1
Ele, PU1
Ukpabi, OJ1
Daga, SR1
Patil, VB1
Verma, B1
Oduro, AR1
Anyorigiya, T1
Hodgson, A1
Ansah, P1
Anto, F1
Ansah, NA1
Atuguba, F1
Mumuni, G1
Amankwa, J1
Ozkurt, Z1
Erol, S1
Kadanali, A1
Altoparlak, U1
Taşyaran, MA1
Boecken, GH1
Bronnert, J1
Chapoy, P1
Vovan, L1
Theveniau, D1
Garnier, JM1
Perrimond, H1
Louchet, E1
Sowunmi, A2
Fehintola, FA2
Adedeji, AA2
Gbotosho, GO1
Tambo, E1
Fateye, BA1
Happi, TC1
Oduola, AM2
Ndiaye, P2
Tal-Dia, A1
Diedhiou, A1
Juergens-Behr, A1
Lemort, JP1
Hugosson, E1
Montgomery, SM1
Premji, Z1
Troye-Blomberg, M1
Björkman, A1
Nsabagasani, X1
Källander, K1
Conteh, L1
Stevens, W1
Wiseman, V1
Taubitz, W1
Cramer, JP1
Kapaun, A1
Pfeffer, M1
Drosten, C1
Dobler, G1
Burchard, GD1
Löscher, T1
Nsungwa-Sabiiti, J1
Ogwal-Okeng, J1
Petzold, MG1
Nahum, A1
Erhart, A1
Gazard, D1
Agbowai, C1
Van Overmeir, C1
van Loen, H1
Menten, J1
Akogbeto, M1
Coosemans, M1
Massougbodji, A1
D'Alessandro, U1
Kouyaté, B1
Somé, F1
Jahn, A1
Coulibaly, B1
Eriksen, J1
Sauerborn, R1
Gustafsson, L1
Becher, H1
Mueller, O1
Das, LK1
Jambulingam, P1
Sadanandane, C1
Pazzaglia, G1
Woodward, WE1
Mabeza, GF1
Moyo, VM1
Thuma, PE1
Biemba, G1
Parry, D1
Khumalo, H1
Nyarugwe, P1
Zulu, S1
Gordeuk, VR1
Commey, J1
Quarm-Goka, B1
Agyepong, I1
Slutsker, L2
Chitsulo, L1
Macheso, A1
Steketee, RW2
Raharimalala, L1
Lepers, JP1
Lepers-Rason, MD1
Rabarison, P1
Ramambanirina, L1
Roux, J2
Barnish, G1
Maude, GH1
Bockarie, MJ1
Eggelte, TA2
Greenwood, BM1
Mukherjee, H1
Hati, AK1
Wirima, JJ1
Khoromana, CO1
Heymann, DL1
Breman, JG1
Vanijanonta, S1
Chantra, A1
Phophak, N1
Chindanond, D1
Clemens, R1
Pukrittayakamee, S1
Sokhna, CS1
Molez, JF1
Sane, B1
Trape, JF1
Saxena, A1
Sharma, VP1
Musabayane, CT1
Musvibe, A1
Wenyika, J1
Munjeri, O1
Osim, EE1
Novitzky, N1
Marsh, VM1
Mutemi, WM1
Muturi, J1
Haaland, A1
Watkins, WM2
Otieno, G1
Marsh, K1
Barat, L1
Chipipa, J1
Kolczak, M1
Sukwa, T1
Verhoef, H1
Hodgins, E1
Carter, JY1
Lema, O1
West, CE1
Kok, FJ1
Viraraghavan, R1
Jantausch, B1
Anand, K1
Kant, S1
Kumar, G1
Kapoor, SK1
Rashed, S2
Johnson, H2
Dongier, P2
Moreau, R2
Lee, C2
Lambert, J2
Schaefer, C2
Falade, AG1
Falade, CO1
Akinyinka, OO1
Baume, C1
Helitzer, D1
Kachur, SP1
Nandi, J1
Sharma, SN1
Salako, LA1
Brieger, WR1
Afolabi, BM1
Umeh, RE1
Agomo, PU1
Asa, S1
Adeneye, AK1
Nwankwo, BO1
Akinlade, CO1
Hamel, MJ1
Odhacha, A1
Roberts, JM1
Deming, MS2
Gong, XS1
Talani, P1
Samba, G1
Moyen, G1
Tarimo, DS1
Minjas, JN1
Bygbjerg, IC1
Schultz, MG1
Sauerwein, HP1
DeBenedetti, C1
Berner, H1
Pender, E1
Newman, J1
Gayibor, A1
Murphy, K1
Jones, TS1
Karsa, T1
Aboff, BM1
Robert, V1
Hervy, JP1
Baudon, D1
Legros, F1
Carnevale, P1
McGlone, R1
Mulik, R1
Brandling-Bennett, AD1
Oloo, AJ1
Boriga, DA1
Kariuki, DM1
Collins, WE1
Moir, JS2
Tulloch, JL2
Vrbova, H2
Jolley, DJ2
Heywood, PF2
Alpers, MP2
Metcalfe, P1
Minchinton, RM1
Murphy, MF1
Waters, AH1
Frame, JD1
Baldwin, JM1
Gocke, DJ1
Troup, JM1
Calabro, JJ1
Katz, RM1
Maltz, BA1
Ayitey-Smith, E1
Boye, GL1
Nichani, N1
Lewis, RA1
Seeler, RA1
Miller, RA1
Lin, CH1
Lin, SK1
Geddes, AM1
Powell, RJ1
Lapierre, J1
Holler, C1
Berman, SJ1
Walker, AJ1
Lopez-Antunano, FJ1
Sheehy, TW1
Reba, RC1
Parks, GR1
Powell, RD1
McNamara, JV1
Patel, CC1
Olurin, O1
Stanfield, JP1
Misra, SS1
Sircar, AR1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase III Comparative (Double-blind, Double-dummy) Randomised Multicentre Study to Assess the Safety & Efficacy of Oral Pyronaridine Artesunate (180:60 mg) Versus Chloroquine (155 mg) in Children & Adult Patients With Acute Vivax Malaria[NCT00440999]Phase 3456 participants (Actual)Interventional2007-03-31Completed
Comparison of the Susceptibility of Naive and Pre-immune Volunteers to Infectious Challenge With Viable Plasmodium Vivax Sporozoites.[NCT01585077]Phase 1/Phase 216 participants (Actual)Interventional2012-10-31Completed
Evaluation of the Protective Efficacy of a Vaccine Derived From the Synthetic CS Protein of Plasmodium Vivax[NCT02083068]Phase 232 participants (Actual)Interventional2014-08-31Completed
Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya[NCT02281123]200 participants (Anticipated)Observational2014-07-31Active, not recruiting
A Comparative Study of Mefloquine and Sulphadoxine-pyrimethamine as Prophylaxis Against Malaria in Pregnant Human Immunodeficiency Virus Positive Patients[NCT02524444]Phase 1142 participants (Actual)Interventional2015-09-30Completed
Phase 1 and Phase 2a Clinical Trial:Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites[NCT01082341]Phase 1/Phase 227 participants (Actual)Interventional2012-06-30Completed
Evaluation of Reproducibility of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers[NCT00367380]Phase 218 participants (Actual)Interventional2006-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Fever Clearance Time

Fever clearance time is defined as the time from first dosing to the first normal reading of temperature (<37.5°C for axillary/tympanic or <38°C for oral/rectal) for 2 consecutive normal temperature readings taken between 7 and 25 hours apart. (NCT00440999)
Timeframe: Days 0 to 42

Interventionhours (Median)
Pyronaridine Artesunate15.8
Chloroquine23.8

Parasite Clearance Time

Parasite clearance time is defined as the time from first dosing to the time of first blood draw with parasite clearance. Parasite clearance is defined as zero presence of asexual parasites for 2 consecutive negative readings taken between 7 and 25 hours apart. (NCT00440999)
Timeframe: Days 0 to 42

Interventionhours (Median)
Pyronaridine Artesunate23.1
Chloroquine32.0

Crude Cure Rate on Day 14

Cure rate on Day 14 is defined as the absence of P. vivax parasitaemia on Day 14 irrespective of temperature (axillary, oral, tympanic, rectal) without previously meeting any of the criteria of treatment failure throughout the follow-up period. (NCT00440999)
Timeframe: Day 14

,
InterventionParticipants (Count of Participants)
Total curedCambodiaIndiaIndonesia/MaumereThailand/Mae SotThailand/Mae Ramatbaseline P. vivax = 250-5,000/uLbaseline P. vivax = >5,000/uL-10,000/uLbaseline P. vivax = >10,000/uLage ≤ 12 yearsage ≥ 12 yearsGender - MaleGender - FemalePrevious P. vivax episode in the past = noPrevious P. vivax episode in the past = yes
Chloroquine2097333104647805970111981486193116
Pyronaridine Artesunate21775331149506958891320416453107110

Crude Cure Rate on Days 21 and 28.

Cure on Day 21 and 28 is defined as the absence of P. vivax parasitaemia on Day 21 and 28 irrespective of temperature (axillary, oral, tympanic, rectal) without previously meeting any of the criteria of treatment failure throughout the follow-up period. (NCT00440999)
Timeframe: Day 21 and 28

,
Interventionpercentage of cured subjects (Number)
Cure rate (%) at Day 21Cure rate (%) at Day 28
Chloroquine99.598.0
Pyronaridine Artesunate99.597.1

Number of Participants With Adverse Events

Number of participants with adverse events, including clinically significant laboratory results, ECG, vital signs or physical examination abnormalities. (NCT00440999)
Timeframe: Day 0 to 42. Subjects experiencing AEs at Day 42 were followed for up to 30 days after the end of study or resolution of the event, whichever was earlier

,
InterventionParticipants (Count of Participants)
Nr subj. with ≥1 AENr subj. with ≥1 treatment-related AENr subj. with ≥1 SAENr subj. with ≥1 treatment-related SAENr subj. with ≥1 severe or life-threatening AENr subj. with ≥1 AE leading to deathNr subj. ≥1 AE leading to study drug discontinuationNr subj. with ≥1 AE leading to study withdrawal
Chloroquine7223002022
Pyronaridine Artesunate9227200000

Percentage of Subjects With Crude and PCR-corrected Cure Rate on Day 42

Cure on Day 42 is defined as the absence of P. vivax parasitaemia on Day 42 irrespective of temperature (axillary, oral, tympanic, rectal) without previously meeting any of the criteria of treatment failure throughout the follow-up period. (NCT00440999)
Timeframe: Day 42

,
Interventionpercentage of subjects (Number)
Crude cure rate (%)PCR-corrected cure rate (%)
Chloroquine92.194.1
Pyronaridine Artesunate95.595.0

Percentage of Subjects With Fever Clearance on Days 1, 2, and 3

Percentage of subjects with fever clearance on Day 1 (24 hours after first dose), Day 2 (48 hours after first dose), and Day 3 (72 hours after first dose). (NCT00440999)
Timeframe: Day 1, 2, and 3

,
Interventionpercentage of subjects (Number)
Clearance rate (%) at Day 1 (24h after first dose)Clearance rate (%) at Day 2 (48h after first dose)Clearance rate (%) at Day 3 (72h after first dose)
Chloroquine58.488.397.4
Pyronaridine Artesunate78.689.997.0

Percentage of Subjects With Parasite Clearance on Days 1, 2, and 3

Percentage of subjects with parasite clearance on Day 1 (24 hours after first dose), Day 2 (48 hours after first dose), and Day 3 (72 hours after first dose). (NCT00440999)
Timeframe: Days 1, 2, and 3

,
Interventionpercentage of subjects (Number)
Clearance rate (%) at Day 1 (24h after first dose)Clearance rate (%) at Day 2 (48h after first dose)Clearance rate (%) at Day 3 (72h after first dose)
Chloroquine30.688.096.7
Pyronaridine Artesunate71.699.5100.0

Percentage of Subjects With PCR-corrected Cure Rate on Days 14, 21, and 28

Cure on Days 14, 21, and 28 is defined as the absence of P. vivax parasitaemia on Days 14, 21, and 28 irrespective of temperature (axillary, oral, tympanic, rectal) without previously meeting any of the criteria of treatment failure throughout the follow-up period. (NCT00440999)
Timeframe: Day 14, 21, and 28

,
Interventionpercentage of subjects (Number)
Cure rate (%) at Day 14Cure rate (%) at Day 21Cure rate (%) at Day 28
Chloroquine99.599.597.9
Pyronaridine Artesunate100.0100.098.1

Infection for P. Vivax

Thick blood smear was performed to patients daily on days 7 to 23, and every other day until day 29. Any prove of P. vivax infection was considered positive and confirmed later by real time polymerase chain reaction (rPCR). (NCT00367380)
Timeframe: Twenty eight days

Interventiondays (Mean)
Group 111
Group 211
Group 39

Reviews

1 review available for chloroquine and Pyrexia

ArticleYear
A critical reappraisal of juvenile rheumatoid arthritis.
    Clinical orthopaedics and related research, 1971, Volume: 74

    Topics: Agammaglobulinemia; Arthritis, Juvenile; Aspirin; Cardiomegaly; Child; Child, Preschool; Chloroquine

1971

Trials

13 trials available for chloroquine and Pyrexia

ArticleYear
Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial.
    PloS one, 2011, Jan-18, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Do

2011
Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.
    The American journal of tropical medicine and hygiene, 2011, Volume: 84, Issue:2 Suppl

    Topics: Adult; Animals; Antimalarials; Chloroquine; Duffy Blood-Group System; Female; Fever; Humans; Malaria

2011
Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.
    The American journal of tropical medicine and hygiene, 2011, Volume: 84, Issue:2 Suppl

    Topics: Adult; Animals; Antimalarials; Chloroquine; Duffy Blood-Group System; Female; Fever; Humans; Malaria

2011
Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.
    The American journal of tropical medicine and hygiene, 2011, Volume: 84, Issue:2 Suppl

    Topics: Adult; Animals; Antimalarials; Chloroquine; Duffy Blood-Group System; Female; Fever; Humans; Malaria

2011
Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.
    The American journal of tropical medicine and hygiene, 2011, Volume: 84, Issue:2 Suppl

    Topics: Adult; Animals; Antimalarials; Chloroquine; Duffy Blood-Group System; Female; Fever; Humans; Malaria

2011
Effect of zinc on the treatment of Plasmodium falciparum malaria in children: a randomized controlled trial.
    The American journal of clinical nutrition, 2002, Volume: 76, Issue:4

    Topics: Animals; Child, Preschool; Chloroquine; Double-Blind Method; Ecuador; Fever; Ghana; Hospitalization;

2002
[In vivo evaluation of chloroquine therapeutic efficacy in uncomplicated Plasmodium falciparum malaria in Central African Republic ine 1997 and 1998].
    Bulletin de la Societe de pathologie exotique (1990), 2003, Volume: 96, Issue:1

    Topics: Administration, Oral; Antimalarials; Central African Republic; Chloroquine; Drug Resistance; Endemic

2003
A randomized comparative study of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Ghana.
    Tropical medicine & international health : TM & IH, 2005, Volume: 10, Issue:3

    Topics: Amodiaquine; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Female; Fever; Ghana;

2005
Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children.
    Tropical medicine & international health : TM & IH, 2005, Volume: 10, Issue:11

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug Com

2005
Home-based management of fever and malaria treatment practices in Uganda.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007, Volume: 101, Issue:12

    Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Services; Drug Combinations; D

2007
Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa.
    Malaria journal, 2007, Dec-21, Volume: 6

    Topics: Analysis of Variance; Anemia; Animals; Antimalarials; Artemisinins; Artesunate; Benin; Child, Presch

2007
Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial.
    Malaria journal, 2008, Mar-25, Volume: 7

    Topics: Anemia; Animals; Burkina Faso; Child, Preschool; Chloroquine; Female; Fever; Humans; Infant; Malaria

2008
Predictors of severity of illness on presentation in children with cerebral malaria.
    Annals of tropical medicine and parasitology, 1995, Volume: 89, Issue:3

    Topics: Age of Onset; Anemia; Child, Preschool; Chloroquine; Coma; Double-Blind Method; Drug Resistance; Fem

1995
Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria.
    Annals of tropical medicine and parasitology, 1996, Volume: 90, Issue:3

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Antimalarials; Chloroquine; Drug Therapy, Combination; Fev

1996
Comparative efficacy of chloroquine plus chlorpheniramine alone and in a sequential combination with sulfadoxine-pyrimethamine, for the treatment of acute, uncomplicated, falciparum malaria in children.
    Annals of tropical medicine and parasitology, 2000, Volume: 94, Issue:3

    Topics: Animals; Antimalarials; Antipruritics; Child; Child, Preschool; Chloroquine; Chlorpheniramine; Drug

2000
Sulfadoxine-pyrimethamine monotherapy in Tanzanian children gives rapid parasite clearance but slow fever clearance that is improved by chloroquine in combination therapy.
    Tropical medicine & international health : TM & IH, 2002, Volume: 7, Issue:7

    Topics: Acetaminophen; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Dru

2002

Other Studies

85 other studies available for chloroquine and Pyrexia

ArticleYear
Brief Report: Retrospective Evaluation on the Efficacy of Lopinavir/Ritonavir and Chloroquine to Treat Nonsevere COVID-19 Patients.
    Journal of acquired immune deficiency syndromes (1999), 2020, 10-01, Volume: 85, Issue:2

    Topics: Adult; Antimalarials; Chloroquine; Chronic Disease; Coronavirus Infections; COVID-19; Drug Combinati

2020
Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: Adult; Aged; Blood Coagulation; Chloroquine; Coinfection; Comorbidity; Cough; COVID-19; COVID-19 Dru

2020
Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status.
    BMC infectious diseases, 2017, 04-24, Volume: 17, Issue:1

    Topics: Adult; Antimalarials; Chloroquine; Fever; Humans; Liberia; Malaria; Malaria, Vivax; Male; Molecular

2017
Human babesiosis in Southeast China: A case report.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2018, Volume: 68

    Topics: Administration, Intravenous; Anemia, Hemolytic; Anti-Bacterial Agents; Azithromycin; Babesiosis; C-R

2018
A 38-year-old man with fever and a history of malaria.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018, 09-10, Volume: 190, Issue:36

    Topics: Adult; Antimalarials; Chloroquine; Diagnosis, Differential; Fever; Humans; Malaria, Vivax; Male; Pri

2018
Concomitant
    BMJ case reports, 2018, Dec-09, Volume: 11, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Antimalarials; Chloroquine; Coinfection; Female; Fever; Humans; Malari

2018
Don't forget the past: A sleeping disease can be awakened.
    Journal of paediatrics and child health, 2019, Volume: 55, Issue:7

    Topics: Chloroquine; Emergency Service, Hospital; Emigration and Immigration; Eritrea; Female; Fever; Humans

2019
Birth of the pharmaceutical specialty.
    Archivos de la Sociedad Espanola de Oftalmologia, 2019, Volume: 94, Issue:11

    Topics: Antimalarials; Chloroquine; Drug Compounding; Drug Packaging; Fever; History, 19th Century; Spain; T

2019
Scrub typhus and malaria co-infection causing severe sepsis.
    Tropical doctor, 2014, Volume: 44, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Azithromycin; Chloroquine; Coinfection; Doxycycline; Enzyme-Linked I

2014
SLE and dental erosion: a lethal cocktail.
    Tropical doctor, 2014, Volume: 44, Issue:2

    Topics: Adolescent; Anti-Inflammatory Agents; Antirheumatic Agents; Chloroquine; Female; Fever; Fruit; Human

2014
Interactive medical case. A chilly fever.
    The New England journal of medicine, 2014, Oct-16, Volume: 371, Issue:16

    Topics: Adult; Antimalarials; Chloroquine; Diagnosis, Differential; Fever; Humans; Life Cycle Stages; Malari

2014
Clinical problem-solving. A chilly fever.
    The New England journal of medicine, 2014, Nov-06, Volume: 371, Issue:19

    Topics: Adult; Antimalarials; Blood; Chloroquine; Circadian Rhythm; Diagnosis, Differential; Fever; Humans;

2014
Fever in the returning traveller: the importance of sensitivity.
    BMJ case reports, 2015, Oct-13, Volume: 2015

    Topics: Adult; Antimalarials; Cameroon; Chloroquine; Diagnosis, Differential; Fever; Follow-Up Studies; Huma

2015
[Fever and chills in an 85-year-old woman].
    La Revue de medecine interne, 2016, Volume: 37, Issue:7

    Topics: Aged, 80 and over; Anemia, Sideroblastic; Antimalarials; Chills; Chloroquine; Diagnosis, Differentia

2016
Early home treatment of childhood fevers with ineffective antimalarials is deleterious in the outcome of severe malaria.
    Malaria journal, 2008, Jul-29, Volume: 7

    Topics: Age Factors; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Fever; Humans; Infant; Mal

2008
Low validity of caretakers' reports on use of selected antimalarials and antibiotics in children with severe pneumonia at an urban hospital in Uganda.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2009, Volume: 103, Issue:1

    Topics: Anti-Infective Agents; Antimalarials; Caregivers; Child, Preschool; Chloroquine; Cross-Sectional Stu

2009
Plasmodium vivax malaria presenting with skin rash--a case report.
    Journal of vector borne diseases, 2011, Volume: 48, Issue:4

    Topics: Antimalarials; Child; Chloroquine; Exanthema; Female; Fever; Histamine Antagonists; Humans; Malaria,

2011
Acute life-threatening methaemoglobinaemia following ingestion of chloroquine.
    BMJ case reports, 2012, Mar-20, Volume: 2012

    Topics: Acute Disease; Adult; Antimalarials; Chloroquine; Diagnosis, Differential; Enzyme Inhibitors; Fever;

2012
Fever in a 20-year-old returned traveler.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013, Volume: 56, Issue:3

    Topics: Antimalarials; Chloroquine; Female; Fever; Humans; Malaria; Plasmodium malariae; Travel; Treatment O

2013
Early treatment of childhood fevers with pre-packaged antimalarial drugs in the home reduces severe malaria morbidity in Burkina Faso.
    Tropical medicine & international health : TM & IH, 2003, Volume: 8, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Aspirin; Burkina Faso; Child, Preschool; Chl

2003
The clinical and epidemiological features of childhood malaria in a moderately endemic area of Sri Lanka.
    The Southeast Asian journal of tropical medicine and public health, 2002, Volume: 33, Issue:4

    Topics: Administration, Oral; Antimalarials; Arthralgia; Case-Control Studies; Child; Child Welfare; Child,

2002
Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal community.
    The American journal of tropical medicine and hygiene, 2003, Volume: 68, Issue:5

    Topics: Adolescent; Adult; Age Factors; Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroqu

2003
Prevalence of Plasmodium falciparum infection in pregnant women in Gabon.
    Malaria journal, 2003, Jun-25, Volume: 2

    Topics: Adolescent; Adult; Age Factors; Animals; Chloroquine; Female; Fever; Gabon; Gravidity; Hemoglobin, S

2003
Assessment of doctors' management of severe malaria in urban centres in Eastern Nigeria.
    African journal of medicine and medical sciences, 2004, Volume: 33, Issue:2

    Topics: Adult; Analgesics; Analgesics, Non-Narcotic; Anemia; Antimalarials; Blood Transfusion; Chloroquine;

2004
Syndromic management of prolonged fever: a cost-effective approach.
    Tropical doctor, 2005, Volume: 35, Issue:1

    Topics: Anti-Infective Agents; Antimalarials; Chloramphenicol; Chloroquine; Cost-Benefit Analysis; Drug Ther

2005
[A transfusion-transmitted malaria case].
    Mikrobiyoloji bulteni, 2005, Volume: 39, Issue:1

    Topics: Animals; Antimalarials; Blood Donors; Chills; Chloroquine; Diarrhea; Female; Fever; Humans; Jaundice

2005
Pathogenesis and management of a late manifestation of vivax malaria after deployment to Afghanistan: conclusions for NATO Armed Forces Medical Services.
    Military medicine, 2005, Volume: 170, Issue:6

    Topics: Adult; Afghanistan; Anemia; Antimalarials; Chloroquine; Fever; Germany; Hospitals, Military; Humans;

2005
[Malaria in childhood and G6PD deficiency. Report of three cases].
    Annales de pediatrie, 1978, Volume: 25, Issue:10

    Topics: Adolescent; Antimalarials; Black People; Blood Transfusion; Child; Chloroquine; Comoros; Emergency T

1978
[Self-treatment of fever in the northern district of Dakar, Senegal].
    Medecine tropicale : revue du Corps de sante colonial, 2006, Volume: 66, Issue:1

    Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Studies; Dru

2006
Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes.
    Acta tropica, 2006, Volume: 99, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Child, Preschool; Chloroquine; Cyto

2006
Home-based management of fever in rural Uganda: community perceptions and provider opinions.
    Malaria journal, 2007, Jan-26, Volume: 6

    Topics: Adolescent; Adult; Antimalarials; Child, Preschool; Chloroquine; Community Health Services; Communit

2007
The role of communication between clients and health care providers: implications for adherence to malaria treatment in rural Gambia.
    Tropical medicine & international health : TM & IH, 2007, Volume: 12, Issue:3

    Topics: Antimalarials; Attitude to Health; Child; Child, Preschool; Chloroquine; Communication Barriers; Dru

2007
Chikungunya fever in travelers: clinical presentation and course.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Jul-01, Volume: 45, Issue:1

    Topics: Adolescent; Adult; Alphavirus Infections; Arthralgia; Chikungunya virus; Child; Chloroquine; Female;

2007
Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India.
    Malaria journal, 2008, May-05, Volume: 7

    Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Workers;

2008
An analysis of the relationship of host factors to clinical falciparum malaria by multiple regression techniques.
    The American journal of tropical medicine and hygiene, 1982, Volume: 31, Issue:2

    Topics: Adult; Age Factors; Black People; Body Weight; Chloroquine; Clindamycin; Fever; Humans; Malaria; Mal

1982
Persistent fever in severe malaria in children.
    The Central African journal of medicine, 1994, Volume: 40, Issue:9

    Topics: Anti-Bacterial Agents; Child; Child, Preschool; Chloroquine; Chronic Disease; Drug Resistance; Femal

1994
Treatment of malaria fever episodes among children in Malawi: results of a KAP survey.
    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1994, Volume: 45, Issue:1

    Topics: Algorithms; Ambulatory Care Facilities; Antimalarials; Caregivers; Child; Child, Preschool; Chloroqu

1994
[Aspects of Plasmodium falciparum sensitivity to chloroquine in Madagascar from 1982 to 1993].
    Archives de l'Institut Pasteur de Madagascar, 1993, Volume: 60, Issue:1-2

    Topics: Animals; Chloroquine; Drug Resistance; Fever; Humans; Madagascar; Malaria, Falciparum; Plasmodium fa

1993
The epidemiology of malaria in southern Sierra Leone.
    Parassitologia, 1993, Volume: 35 Suppl

    Topics: Child; Child, Preschool; Chloroquine; Comorbidity; Cross-Sectional Studies; Female; Fever; Hematocri

1993
Atypical postponing of fever in a case of vivax malaria.
    Journal of the Indian Medical Association, 1995, Volume: 93, Issue:7

    Topics: Adult; Chloroquine; Fever; Humans; Malaria, Vivax; Male; Time Factors

1995
Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine.
    The American journal of tropical medicine and hygiene, 1996, Volume: 55, Issue:1 Suppl

    Topics: Adolescent; Adult; Antimalarials; Chloroquine; Female; Fetal Death; Fever; Humans; Malaria, Falcipar

1996
[In vivo chemosensitivity tests of Plasmodium falciparum to chloroquine in Senegal: the development of resistance and the assessment of therapeutic efficacy].
    Bulletin de la Societe de pathologie exotique (1990), 1997, Volume: 90, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Ambulatory Care; Animals; Antimalarials; Bias; Chemop

1997
Studies on malaria during pregnancy in a tribal area of central India (Madhya Pradesh).
    The Southeast Asian journal of tropical medicine and public health, 1998, Volume: 29, Issue:1

    Topics: Adult; Antimalarials; Chloroquine; Female; Fever; Hemoglobins; Humans; India; Malaria; Malaria, Falc

1998
Chloroquine influences renal function in rural Zimbabweans with acute transient fever.
    Renal failure, 1999, Volume: 21, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Blood Pressure; Chloroquin

1999
A case of fever, confusion and anaemia in a young woman.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1999, Volume: 89, Issue:4

    Topics: Adult; Anemia; Antimalarials; Chloroquine; Confusion; Drug Therapy, Combination; Female; Fever; Huma

1999
Changing home treatment of childhood fevers by training shop keepers in rural Kenya.
    Tropical medicine & international health : TM & IH, 1999, Volume: 4, Issue:5

    Topics: Analgesics, Non-Narcotic; Antimalarials; Child; Chloroquine; Community Pharmacy Services; Drug Infor

1999
Does the availability of blood slide microscopy for malaria at health centers improve the management of persons with fever in Zambia?
    The American journal of tropical medicine and hygiene, 1999, Volume: 60, Issue:6

    Topics: Ambulatory Care Facilities; Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations

1999
Anti-malarial drug use among preschool children in an area of seasonal malaria transmission in Kenya.
    The American journal of tropical medicine and hygiene, 1999, Volume: 61, Issue:5

    Topics: Adult; Animals; Antibodies, Monoclonal; Antimalarials; Child, Preschool; Chloroquine; Cluster Analys

1999
Congenital malaria: diagnosis and therapy.
    Clinical pediatrics, 2000, Volume: 39, Issue:1

    Topics: Animals; Antimalarials; Chloroquine; District of Columbia; Female; Fever; Humans; Infant; Jaundice;

2000
Clinical case definition of malaria at a secondary level hospital in northern India.
    The Southeast Asian journal of tropical medicine and public health, 1999, Volume: 30, Issue:2

    Topics: Analysis of Variance; Antimalarials; Case-Control Studies; Child; Chloroquine; Female; Fever; Humans

1999
Economic impact of febrile morbidity and use of permethrin-impregnated bed-nets in a malarious area I. Study of demographics, morbidity, and household expenditures associated with febrile morbidity in the Republic of Benin.
    The American journal of tropical medicine and hygiene, 2000, Volume: 62, Issue:2

    Topics: Adult; Animals; Anopheles; Antimalarials; Attitude to Health; Bedding and Linens; Benin; Child, Pres

2000
Economic impact of febrile morbidity and use of permethrin-impregnated bed nets in a malarious area II. Determinants of febrile episodes and the cost of their treatment and malaria prevention.
    The American journal of tropical medicine and hygiene, 2000, Volume: 62, Issue:2

    Topics: Adult; Animals; Anopheles; Antimalarials; Bedding and Linens; Benin; Child, Preschool; Chloroquine;

2000
Patterns of care for childhood malaria in Zambia.
    Social science & medicine (1982), 2000, Volume: 51, Issue:10

    Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Female; Fever; Health Care Surveys;

2000
Efficacy of chloroquine in febrile Plasmodium falciparum infected children in Mewat region of Haryana.
    The Journal of communicable diseases, 2000, Volume: 32, Issue:2

    Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Fever; Humans; Infant; Mal

2000
Treatment of childhood fevers and other illnesses in three rural Nigerian communities.
    Journal of tropical pediatrics, 2001, Volume: 47, Issue:4

    Topics: Anti-Bacterial Agents; Antimalarials; Child; Child, Preschool; Chloroquine; Cough; Female; Fever; He

2001
Malaria control in Bungoma District, Kenya: a survey of home treatment of children with fever, bednet use and attendance at antenatal clinics.
    Bulletin of the World Health Organization, 2001, Volume: 79, Issue:11

    Topics: Antimalarials; Bedding and Linens; Child; Child Care; Chloroquine; Cluster Analysis; Communicable Di

2001
Effective control of infection-associated hemophagocytic syndrome with chloroquine.
    Journal of pediatric hematology/oncology, 2002, Volume: 24, Issue:4

    Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Fever; Histiocytosis, Non-L

2002
[Management of child fever in the battle against malaria in Brazzaville].
    Bulletin de la Societe de pathologie exotique (1990), 2002, Volume: 95, Issue:1

    Topics: Amodiaquine; Antimalarials; Asthenia; Child, Preschool; Chills; Chloroquine; Congo; Diarrhea; Fever;

2002
Exotic diseases. Ounce of prevention or pound of cure?
    Postgraduate medicine, 1977, Volume: 62, Issue:2

    Topics: Beverages; Chloroquine; Clioquinol; Diagnosis; Diarrhea; Drug Resistance, Microbial; Eosinophils; Fe

1977
[A patient with high fever].
    Nederlands tijdschrift voor geneeskunde, 1977, May-28, Volume: 121, Issue:22

    Topics: Chloroquine; Fever; Humans; Indonesia; Malaria; Male; Middle Aged; Netherlands; Nigeria; Plasmodium

1977
Juvenile rheumatoid arthritis.
    Comprehensive therapy, 1976, Volume: 2, Issue:10

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Arthritis, Juvenile; Aspirin;

1976
[Malaria in children, with special reference to cerebral malaria (author's transl)].
    Klinische Padiatrie, 1975, Volume: 187, Issue:5

    Topics: Age Factors; Anemia, Hemolytic; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; Chloroquine

1975
Malaria in children.
    Pediatric emergency care, 1990, Volume: 6, Issue:1

    Topics: Adolescent; Anemia; Animals; Child; Chloroquine; Diagnosis, Differential; Emergencies; Female; Fever

1990
Home treatment of febrile children with antimalarial drugs in Togo.
    Bulletin of the World Health Organization, 1989, Volume: 67, Issue:6

    Topics: Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Fever; Home Nursing; Humans;

1989
Febrile illness in an Afghani "freedom fighter".
    Journal of the Tennessee Medical Association, 1989, Volume: 82, Issue:11

    Topics: Administration, Oral; Adult; Afghanistan; Animals; Chloroquine; Emigration and Immigration; Fever; H

1989
[The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1989, Volume: 82, Issue:2

    Topics: Adolescent; Animals; Anopheles; Burkina Faso; Child; Child, Preschool; Chloroquine; Dose-Response Re

1989
Hypnozoites in Bradford.
    Archives of emergency medicine, 1988, Volume: 5, Issue:4

    Topics: Animals; Child, Preschool; Chloroquine; England; Fever; Humans; Infant, Newborn; Malaria; Male; Plas

1988
Chloroquine treatment of falciparum malaria in an area of Kenya of intermediate chloroquine resistance.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:6

    Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Fever; Humans; Infant; Kenya; Malari

1988
The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 1. Selection, training and practice.
    Papua and New Guinea medical journal, 1985, Volume: 28, Issue:4

    Topics: Adult; Amodiaquine; Attitude to Health; Chloroquine; Community Health Workers; Female; Fever; Humans

1985
The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health.
    Papua and New Guinea medical journal, 1985, Volume: 28, Issue:4

    Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Community Health Workers; Fever; Huma

1985
Use of chloroquine-treated granulocytes and platelets in the diagnosis of immune cytopenias.
    Vox sanguinis, 1985, Volume: 49, Issue:5

    Topics: Adult; Antibodies; Autoantibodies; Autoimmune Diseases; Blood Platelets; Chloroquine; Female; Fever;

1985
Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings.
    The American journal of tropical medicine and hygiene, 1970, Volume: 19, Issue:4

    Topics: Acute Disease; Adult; Aged; Autopsy; Back Pain; Blood; Blood Cell Count; Chloroquine; Edema; Female;

1970
Effect of hyperthermia on acute chloroquine toxicity in rabbits.
    European journal of pharmacology, 1974, Volume: 25, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Chloroquine; Electrocardiography; Female; Fever; Male

1974
Transfusion-induced malaria. Plasmodium vivax in a 5-month-old child.
    American journal of diseases of children (1960), 1973, Volume: 125, Issue:1

    Topics: Chloroquine; Fever; Hemolysis; Hepatomegaly; Humans; Infant; Malaria; Male; Plasmodium vivax; Primaq

1973
Imported infections. Unexplained fever.
    British medical journal, 1974, Nov-16, Volume: 4, Issue:5941

    Topics: Africa; Asia; Brucellosis; Chloramphenicol; Chloroquine; Fever; Humans; Leishmaniasis, Visceral; Liv

1974
Systemic lupus erythematosus with widespread subcutaneous fat calcification.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:3

    Topics: Adipose Tissue; Adult; Calcinosis; Chloroquine; Female; Fever; Humans; Lupus Erythematosus, Systemic

1974
[A febrile crisis of suspected malarial etiology in a person returning from the tropics].
    La Nouvelle presse medicale, 1974, Jun-29, Volume: 3, Issue:26

    Topics: Antimalarials; Blood; Chloroquine; Drug Synergism; Fever; Humans; Liver Function Tests; Malaria; Pla

1974
Chloroquine-pyrimethamine-sulfisoxazole therapy of Plasmodium falciparum malaria. An alternative to quinine.
    JAMA, 1969, Jan-06, Volume: 207, Issue:1

    Topics: Chloroquine; Dapsone; Drug Resistance, Microbial; Fever; Humans; Malaria; Male; Military Medicine; P

1969
Response to drugs of South American strains of Plasmodium falciparum.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1968, Volume: 62, Issue:5

    Topics: Chloroquine; Drug Resistance, Microbial; Drug Synergism; Fever; Humans; Malaria; Plasmodium falcipar

1968
Combined pyrimethamine-quinine therapy for chloroquine-resistant P. falciparum infections.
    Southern medical journal, 1969, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Agranulocytosis; Anemia, Hemolytic; Chloroquine; Clinical Laboratory Techniques;

1969
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
    Annals of the New York Academy of Sciences, 1970, Oct-30, Volume: 174, Issue:2

    Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial

1970
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
    Annals of the New York Academy of Sciences, 1970, Oct-30, Volume: 174, Issue:2

    Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial

1970
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
    Annals of the New York Academy of Sciences, 1970, Oct-30, Volume: 174, Issue:2

    Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial

1970
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
    Annals of the New York Academy of Sciences, 1970, Oct-30, Volume: 174, Issue:2

    Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial

1970
Acute febrile encephalopathy in Ugandan children.
    The African journal of medical sciences, 1971, Volume: 2, Issue:2

    Topics: Cerebrospinal Fluid; Child; Child, Preschool; Chloroquine; Encephalitis; Female; Fever; Gastrointest

1971
Cortical blindness following convulsions and fever in Nigerian children.
    Pediatrics, 1970, Volume: 46, Issue:1

    Topics: Anti-Bacterial Agents; Anticonvulsants; Blindness; Blood Transfusion; Bronchopneumonia; Cerebral Cor

1970
Fever in children in the tropics.
    British medical journal, 1969, Mar-22, Volume: 1, Issue:5646

    Topics: Anti-Bacterial Agents; Aspirin; Child; Child, Preschool; Chloroquine; Fever; Humans; Hypothermia; Ph

1969
Chloroquine therapy in pyrexia of unknown origin.
    Journal of the Indian Medical Association, 1966, Sep-01, Volume: 47, Issue:5

    Topics: Adult; Chloroquine; Female; Fever; Humans; Male; Middle Aged

1966