chloroquine has been researched along with Pulmonary Hypertension in 8 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to investigate whether chloroquine induced relaxation in the pulmonary artery (PA) and attenuates hypoxia-induced pulmonary hypertension (HPH)." | 7.85 | Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. ( Ayon, RJ; Balistrieri, A; Black, SM; Garcia, JGN; Gu, Y; Liang, Z; Lu, W; Makino, A; McDermott, KM; Song, S; Tang, H; Wang, C; Wang, J; Wang, Z; Wu, K; Wu, X; Yuan, JX; Zhang, Q, 2017) |
| "Chloroquine treatment increased whole lung and PASMC p62 protein levels consistent with inhibition of autophagy, and increased levels of BMPR-II protein." | 5.39 | Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. ( Dunmore, BJ; Long, L; Lu, J; Marciniak, SJ; Morrell, NW; Southwood, M; Yang, X, 2013) |
| " The purpose of this study was to investigate whether chloroquine induced relaxation in the pulmonary artery (PA) and attenuates hypoxia-induced pulmonary hypertension (HPH)." | 3.85 | Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. ( Ayon, RJ; Balistrieri, A; Black, SM; Garcia, JGN; Gu, Y; Liang, Z; Lu, W; Makino, A; McDermott, KM; Song, S; Tang, H; Wang, C; Wang, J; Wang, Z; Wu, K; Wu, X; Yuan, JX; Zhang, Q, 2017) |
| "Chloroquine treatment increased whole lung and PASMC p62 protein levels consistent with inhibition of autophagy, and increased levels of BMPR-II protein." | 1.39 | Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. ( Dunmore, BJ; Long, L; Lu, J; Marciniak, SJ; Morrell, NW; Southwood, M; Yang, X, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Ishikawa, T | 1 |
| Abe, K | 1 |
| Takana-Ishikawa, M | 1 |
| Yoshida, K | 1 |
| Watanabe, T | 1 |
| Imakiire, S | 1 |
| Hosokawa, K | 1 |
| Hirano, M | 1 |
| Hirano, K | 1 |
| Tsutsui, H | 1 |
| Wu, K | 1 |
| Zhang, Q | 1 |
| Wu, X | 1 |
| Lu, W | 1 |
| Tang, H | 1 |
| Liang, Z | 1 |
| Gu, Y | 1 |
| Song, S | 1 |
| Ayon, RJ | 1 |
| Wang, Z | 1 |
| McDermott, KM | 1 |
| Balistrieri, A | 1 |
| Wang, C | 1 |
| Black, SM | 1 |
| Garcia, JGN | 1 |
| Makino, A | 1 |
| Yuan, JX | 2 |
| Wang, J | 1 |
| Zhou, Y | 1 |
| Wang, Y | 2 |
| Wang, X | 1 |
| Tian, X | 1 |
| Zhang, S | 1 |
| Yang, F | 1 |
| Guo, H | 1 |
| Fan, R | 1 |
| Feng, N | 1 |
| Jia, M | 1 |
| Gu, X | 1 |
| Li, J | 1 |
| Pei, J | 1 |
| Long, L | 1 |
| Yang, X | 1 |
| Southwood, M | 1 |
| Lu, J | 1 |
| Marciniak, SJ | 1 |
| Dunmore, BJ | 2 |
| Morrell, NW | 2 |
| Fraidenburg, DR | 1 |
| Drake, KM | 1 |
| Upton, PD | 1 |
| Toshner, MR | 1 |
| Aldred, MA | 1 |
| Ryan, JJ | 1 |
| Teng, RJ | 1 |
| Du, J | 1 |
| Welak, S | 1 |
| Guan, T | 1 |
| Eis, A | 1 |
| Shi, Y | 1 |
| Konduri, GG | 1 |
8 other studies available for chloroquine and Pulmonary Hypertension
| Article | Year |
|---|---|
Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats.
Topics: Animals; Antirheumatic Agents; Chloroquine; Disease Models, Animal; Hypertension, Pulmonary; Male; M | 2021 |
Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.
Topics: Animals; Calcium Channels; Cell Proliferation; Cell Survival; Cells, Cultured; Chloroquine; Humans; | 2017 |
The Protective Effects of Κ-Opioid Receptor Stimulation in Hypoxic Pulmonary Hypertension Involve Inhibition of Autophagy Through the AMPK-MTOR Pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; AMP-Activa | 2017 |
Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
Topics: Animals; Autophagy; Bone Morphogenetic Protein Receptors, Type II; Cells, Cultured; Chloroquine; Dis | 2013 |
Hungry for more: autophagy in the pathogenesis of pulmonary arterial hypertension.
Topics: Animals; Autophagy; Bone Morphogenetic Protein Receptors, Type II; Chloroquine; Hypertension, Pulmon | 2013 |
The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations.
Topics: Bone Morphogenetic Protein Receptors, Type II; Cell Line; Cell Membrane; Cells, Cultured; Chloroquin | 2013 |
Chloroquine in pulmonary arterial hypertension: a new role for an old drug?
Topics: Animals; Autophagy; Bone Morphogenetic Protein Receptors, Type II; Chloroquine; Hypertension, Pulmon | 2013 |
Cross talk between NADPH oxidase and autophagy in pulmonary artery endothelial cells with intrauterine persistent pulmonary hypertension.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Cells, Cultured; Chloroquine; Endothelia | 2012 |