chloroquine has been researched along with Ovarian Neoplasms in 22 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested a panel of 28 epithelial ovarian cancer (EOC) cell lines with itraconazole to define its spectrum of activity." | 5.72 | Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer. ( Bowering, V; Bruce, JP; Cabanero, M; Chen, EX; Colombo, I; Dhani, NC; Garg, S; Gill, S; Joshua, AM; Ketela, T; Koritzinsky, M; Lheureux, S; Li, X; Li, ZJ; Madariaga, A; Mandilaras, V; Marastoni, S; Nair, SN; Oza, AM; Pesic, A; Pintilie, M; Rottapel, R; Shalev, Z; Wang, L; Wouters, BG; Zhang, W, 2022) |
| "Metastatic ovarian cancer spheroids exhibit cancer stem like properties and undergo a metabolic reprogramming when they disseminate from the primary tumor." | 1.72 | Metabolic Reprogramming and Lipophagy Mediates Survival of Ascites Derived Metastatic Ovarian Cancer Cells. ( Devaraj, VR; Gawari, R; N Swamy, S; Pallavi, VR; Premalatha, CS; S, SK; Sagar, BC; Shinde, DD, 2022) |
| "We tested a panel of 28 epithelial ovarian cancer (EOC) cell lines with itraconazole to define its spectrum of activity." | 1.72 | Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer. ( Bowering, V; Bruce, JP; Cabanero, M; Chen, EX; Colombo, I; Dhani, NC; Garg, S; Gill, S; Joshua, AM; Ketela, T; Koritzinsky, M; Lheureux, S; Li, X; Li, ZJ; Madariaga, A; Mandilaras, V; Marastoni, S; Nair, SN; Oza, AM; Pesic, A; Pintilie, M; Rottapel, R; Shalev, Z; Wang, L; Wouters, BG; Zhang, W, 2022) |
| "LBH and CQ inhibited ovarian cancer cell proliferation and induced apoptosis, and a strong synergistic effect was observed when combined." | 1.62 | Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair. ( González-Sarmiento, R; Herrero, AB; Ovejero-Sánchez, M, 2021) |
| "Treatment with olaparib increased phosphorylation of ATM and PTEN while decreasing the phosphorylation of AKT and mTOR and inducing autophagy." | 1.56 | Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. ( Amaravadi, RK; Bast, RC; Becker, SE; Heinzen, EP; Hou, X; Llombart-Cussac, A; Lu, Z; Matias-Guiu, X; Maurer, MJ; Oberg, AL; Pang, L; Poveda, A; Rask, P; Romero, I; Rubio, MJ; Santacana, M; Santiago-O'Farrill, JM; Weroha, SJ, 2020) |
| "Overexpression of PBK decreased ovarian cancer responsiveness to cisplatin treatment through inducing autophagy in vivo." | 1.51 | PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma. ( Gao, M; Kong, B; Li, R; Li, Y; Ma, H; Qi, G; Wang, X; Wu, H; Yan, S; Yang, N; Yuan, C, 2019) |
| " Lastly, doses of proteasome inhibitors that are inadequate to block the activity of the proteasomes, caused cell death when combined with mifepristone; this phenotype was accompanied by accumulation of poly-ubiquitinated proteins denoting proteasome inhibition." | 1.43 | Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors. ( Callegari, EA; Chien, J; Drappeau, DD; Eyster, KM; Gamarra-Luques, CD; Goyeneche, AA; Hapon, MB; Knapp, JR; Pan, B; Srinivasan, R; Telleria, CM; Terpstra, EJ; Wang, X; Zhang, L, 2016) |
| "In this study, ARHI-induced ovarian cancer cell death in culture has been found to depend upon autophagy and has been linked to G1 cell-cycle arrest, enhanced reactive oxygen species (ROS) activity, RIP1/RIP3 activation and necrosis." | 1.42 | ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts. ( Atkinson, N; Bast, RC; Liao, W; Lu, Z; Mao, W; Millward, S; Ornelas, A; Orozco, AF; Suh, G; Sutton, MN; Wang, Y; Washington, MN; Yang, H, 2015) |
| "Clinically, from the largest ovarian cancer data set (GSE 9899, n = 285) available in GEO, high levels of expression of both PTP4A3 and autophagy genes significantly predict poor prognosis of ovarian cancer patients." | 1.40 | A role of autophagy in PTP4A3-driven cancer progression. ( Al-Aidaroos, AQ; Gupta, A; Huang, YH; Lin, YB; McCrudden, CM; Murray, JT; Rozycka, E; Shen, HM; Tergaonkar, V; Thiery, JP; Yuen, HF; Zeng, Q; Zhang, SD, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 11 (50.00) | 24.3611 |
| 2020's | 7 (31.82) | 2.80 |
| Authors | Studies |
|---|---|
| S, SK | 1 |
| N Swamy, S | 1 |
| Devaraj, VR | 1 |
| Premalatha, CS | 1 |
| Pallavi, VR | 1 |
| Sagar, BC | 1 |
| Shinde, DD | 1 |
| Gawari, R | 1 |
| Ovejero-Sánchez, M | 2 |
| Rubio-Heras, J | 1 |
| Vicente de la Peña, MDC | 1 |
| San-Segundo, L | 1 |
| Pérez-Losada, J | 1 |
| González-Sarmiento, R | 2 |
| Herrero, AB | 2 |
| Marastoni, S | 1 |
| Madariaga, A | 1 |
| Pesic, A | 1 |
| Nair, SN | 1 |
| Li, ZJ | 1 |
| Shalev, Z | 1 |
| Ketela, T | 1 |
| Colombo, I | 1 |
| Mandilaras, V | 1 |
| Cabanero, M | 1 |
| Bruce, JP | 1 |
| Li, X | 1 |
| Garg, S | 1 |
| Wang, L | 1 |
| Chen, EX | 1 |
| Gill, S | 1 |
| Dhani, NC | 1 |
| Zhang, W | 2 |
| Pintilie, M | 1 |
| Bowering, V | 1 |
| Koritzinsky, M | 1 |
| Rottapel, R | 1 |
| Wouters, BG | 1 |
| Oza, AM | 1 |
| Joshua, AM | 1 |
| Lheureux, S | 1 |
| Santiago-O'Farrill, JM | 1 |
| Weroha, SJ | 1 |
| Hou, X | 1 |
| Oberg, AL | 1 |
| Heinzen, EP | 1 |
| Maurer, MJ | 1 |
| Pang, L | 1 |
| Rask, P | 1 |
| Amaravadi, RK | 2 |
| Becker, SE | 1 |
| Romero, I | 1 |
| Rubio, MJ | 1 |
| Matias-Guiu, X | 1 |
| Santacana, M | 1 |
| Llombart-Cussac, A | 1 |
| Poveda, A | 1 |
| Lu, Z | 3 |
| Bast, RC | 3 |
| Zhang, D | 1 |
| Reyes, RM | 1 |
| Osta, E | 1 |
| Kari, S | 1 |
| Gupta, HB | 1 |
| Padron, AS | 1 |
| Kornepati, AVR | 1 |
| Kancharla, A | 1 |
| Sun, X | 1 |
| Deng, Y | 1 |
| Wu, B | 1 |
| Vadlamudi, R | 1 |
| Li, R | 2 |
| Svatek, RS | 1 |
| Curiel, TJ | 1 |
| Pan, Y | 1 |
| Zhou, J | 1 |
| Yan, L | 1 |
| Lu, M | 1 |
| Dai, Y | 1 |
| Zhou, H | 1 |
| Zhang, S | 1 |
| Yang, J | 1 |
| Shao, M | 1 |
| Zhu, W | 1 |
| Lv, X | 1 |
| Yang, Q | 1 |
| Liu, X | 1 |
| Xie, Y | 1 |
| Tang, P | 1 |
| Sun, L | 1 |
| Ma, H | 1 |
| Li, Y | 1 |
| Wang, X | 2 |
| Wu, H | 2 |
| Qi, G | 1 |
| Yang, N | 1 |
| Gao, M | 1 |
| Yan, S | 1 |
| Yuan, C | 1 |
| Kong, B | 1 |
| Correa, RJ | 1 |
| Valdes, YR | 1 |
| Peart, TM | 1 |
| Fazio, EN | 1 |
| Bertrand, M | 1 |
| McGee, J | 1 |
| Préfontaine, M | 1 |
| Sugimoto, A | 1 |
| DiMattia, GE | 1 |
| Shepherd, TG | 1 |
| Huang, YH | 1 |
| Al-Aidaroos, AQ | 1 |
| Yuen, HF | 1 |
| Zhang, SD | 1 |
| Shen, HM | 1 |
| Rozycka, E | 1 |
| McCrudden, CM | 1 |
| Tergaonkar, V | 1 |
| Gupta, A | 1 |
| Lin, YB | 1 |
| Thiery, JP | 1 |
| Murray, JT | 1 |
| Zeng, Q | 1 |
| Lang, F | 1 |
| Qin, Z | 1 |
| Li, F | 1 |
| Zhang, H | 1 |
| Fang, Z | 1 |
| Hao, E | 1 |
| Washington, MN | 1 |
| Suh, G | 1 |
| Orozco, AF | 1 |
| Sutton, MN | 1 |
| Yang, H | 1 |
| Wang, Y | 1 |
| Mao, W | 1 |
| Millward, S | 1 |
| Ornelas, A | 1 |
| Atkinson, N | 1 |
| Liao, W | 1 |
| Zhang, L | 2 |
| Hapon, MB | 1 |
| Goyeneche, AA | 1 |
| Srinivasan, R | 1 |
| Gamarra-Luques, CD | 1 |
| Callegari, EA | 1 |
| Drappeau, DD | 1 |
| Terpstra, EJ | 1 |
| Pan, B | 1 |
| Knapp, JR | 1 |
| Chien, J | 1 |
| Eyster, KM | 1 |
| Telleria, CM | 1 |
| Wang, YF | 1 |
| Xu, YL | 1 |
| Tang, ZH | 1 |
| Li, T | 1 |
| Zhang, LL | 1 |
| Chen, X | 1 |
| Lu, JH | 1 |
| Leung, CH | 1 |
| Ma, DL | 1 |
| Qiang, WA | 1 |
| Wang, YT | 1 |
| Lu, JJ | 1 |
| Serikawa, T | 1 |
| Kikuchi, H | 1 |
| Oite, T | 1 |
| Tanaka, K | 1 |
| Luo, RZ | 1 |
| Lu, Y | 1 |
| Zhang, X | 1 |
| Yu, Q | 1 |
| Khare, S | 1 |
| Kondo, S | 1 |
| Kondo, Y | 1 |
| Yu, Y | 1 |
| Mills, GB | 1 |
| Liao, WS | 1 |
| Zhang, Y | 1 |
| Cheng, Y | 1 |
| Ren, X | 1 |
| Yap, KL | 1 |
| Patel, R | 1 |
| Liu, D | 1 |
| Qin, ZH | 1 |
| Shih, IM | 1 |
| Yang, JM | 1 |
| Adar, Y | 1 |
| Stark, M | 1 |
| Bram, EE | 1 |
| Nowak-Sliwinska, P | 1 |
| van den Bergh, H | 1 |
| Szewczyk, G | 1 |
| Sarna, T | 1 |
| Skladanowski, A | 1 |
| Griffioen, AW | 1 |
| Assaraf, YG | 1 |
| Kandala, PK | 1 |
| Srivastava, SK | 1 |
| Peoples, GE | 1 |
| Goedegebuure, PS | 1 |
| Andrews, JV | 1 |
| Schoof, DD | 1 |
| Eberlein, TJ | 1 |
22 other studies available for chloroquine and Ovarian Neoplasms
| Article | Year |
|---|---|
Metabolic Reprogramming and Lipophagy Mediates Survival of Ascites Derived Metastatic Ovarian Cancer Cells.
Topics: Ascites; Autophagy; Chloroquine; Female; Genital Neoplasms, Male; Humans; Lipids; Male; Ovarian Neop | 2022 |
Chloroquine-Induced DNA Damage Synergizes with Nonhomologous End Joining Inhibition to Cause Ovarian Cancer Cell Cytotoxicity.
Topics: Carcinoma, Ovarian Epithelial; Chloroquine; DNA Breaks, Double-Stranded; DNA Damage; DNA End-Joining | 2022 |
Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer.
Topics: Antifungal Agents; Antineoplastic Agents; Carcinoma, Ovarian Epithelial; Chloroquine; Drug Repositio | 2022 |
Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Drug Resistance | 2020 |
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Autophagy; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation | 2021 |
Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival | 2021 |
The Sonic Hedgehog signaling pathway regulates autophagy and migration in ovarian cancer.
Topics: Animals; Autophagic Cell Death; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Chlo | 2021 |
Encapsulation of chloroquine and doxorubicin by MPEG-PLA to enhance anticancer effects by lysosomes inhibition in ovarian cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chlo | 2018 |
PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Cisplatin | 2019 |
Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability.
Topics: Allosteric Regulation; Antineoplastic Agents; Ascites; Autophagy; Benzylamines; Cell Line, Tumor; Ce | 2014 |
A role of autophagy in PTP4A3-driven cancer progression.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy; Biocatalysis; Cell Cycle Proteins; Cell Me | 2014 |
Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Autophagy-Related Protein 5; Caspase 3; Cel | 2015 |
ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.
Topics: Antineoplastic Agents; Autophagy; Caspase 3; Cell Line, Tumor; Chloroquine; Cisplatin; Drug Resistan | 2015 |
Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.
Topics: Activating Transcription Factor 4; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chlor | 2016 |
Baicalein Induces Beclin 1- and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells.
Topics: Antimalarials; Autophagy; Beclin-1; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Su | 2017 |
Enhancement of gene expression efficiency using cationic liposomes on ovarian cancer cells.
Topics: Ammonium Chloride; Cations; Cell Line, Tumor; Chloroquine; Colchicine; Female; Gene Expression; Gene | 2008 |
Autophagy-induced tumor dormancy in ovarian cancer.
Topics: Animals; Antibiotics, Antineoplastic; Antirheumatic Agents; Autophagy; Cell Line, Tumor; Cell Surviv | 2008 |
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; Antirheumatic Agents; Autophagy; Cell Line, Tumor; Cell Surviv | 2008 |
NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Antineoplastic Agents, Alkylating; Autophagy; Cell | 2012 |
Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers.
Topics: Acridones; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, | 2012 |
Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinase Kinases; Autophagy; Autophagy-Rel | 2012 |
HLA-A2 presents shared tumor-associated antigens derived from endogenous proteins in ovarian cancer.
Topics: Antigen Presentation; Antigens, Neoplasm; Brefeldin A; Chloroquine; Cyclopentanes; Cytotoxicity, Imm | 1993 |