chloroquine has been researched along with Osteosarcoma in 11 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated the combined effect of the autophagy inhibitor chloroquine and the mTOR inhibitor rapamycin on MG63 osteosarcoma cells." | 3.91 | Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells. ( Fukuoka, N; Ishibashi, Y; Nakamura, O; Nishimura, H; Yamagami, Y; Yamamoto, T, 2019) |
| " We previously reported that in human melanoma and osteosarcoma cells, autophagy inhibitors, such as 3‑methyladenine and chloroquine increased the sensitivity to apoptosis induced by tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL)." | 3.91 | Autophagy inhibitors regulate TRAIL sensitivity in human malignant cells by targeting the mitochondrial network and calcium dynamics. ( Ochiai, T; Onoe-Takahashi, A; Suzuki-Karasaki, M; Suzuki-Karasaki, Y, 2019) |
| " Here we reported that CA-4 could induce cell-protective autophagy, and combination treatment of CA-4 and autophagy inhibitor chloroquine (CQ) exerted synergistic cytotoxic effect on human osteosarcoma (OS) cells." | 3.85 | NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy. ( Cai, Z; Chang, S; Hua, Y; Li, W; Lin, B; Sun, M; Sun, W; Wang, G; Wang, H; Wang, Z; Xu, J; Zhang, T; Zhou, Z; Zuo, D, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, SC | 1 |
| Chen, HY | 1 |
| Chuang, WL | 1 |
| Wang, HC | 1 |
| Hsieh, CP | 1 |
| Huang, YF | 1 |
| Feng, H | 1 |
| Zhang, Q | 1 |
| Zhao, Y | 1 |
| Zhao, L | 1 |
| Shan, B | 1 |
| Liu, Z | 1 |
| Wang, H | 2 |
| Hu, C | 1 |
| Wu, C | 1 |
| Wang, J | 1 |
| Hu, F | 1 |
| Fu, Y | 1 |
| Wen, J | 1 |
| Zhang, W | 1 |
| Chen, C | 1 |
| Zhang, H | 1 |
| Yu, Y | 1 |
| Huang, Q | 1 |
| Wang, W | 2 |
| Niu, J | 1 |
| Lou, J | 1 |
| Ren, T | 1 |
| Huang, Y | 1 |
| Guo, W | 1 |
| Li, W | 1 |
| Xu, J | 1 |
| Zhang, T | 1 |
| Zuo, D | 1 |
| Zhou, Z | 1 |
| Lin, B | 1 |
| Wang, G | 1 |
| Wang, Z | 1 |
| Sun, W | 1 |
| Sun, M | 1 |
| Chang, S | 1 |
| Cai, Z | 1 |
| Hua, Y | 1 |
| Ishibashi, Y | 1 |
| Nakamura, O | 1 |
| Yamagami, Y | 1 |
| Nishimura, H | 1 |
| Fukuoka, N | 1 |
| Yamamoto, T | 1 |
| Onoe-Takahashi, A | 1 |
| Suzuki-Karasaki, M | 2 |
| Ochiai, T | 1 |
| Suzuki-Karasaki, Y | 1 |
| Shen, C | 1 |
| Tao, L | 1 |
| Liu, B | 1 |
| Yang, Z | 1 |
| Tao, H | 1 |
| Wang, CK | 1 |
| Yu, XD | 1 |
| Li, Q | 1 |
| Xie, G | 1 |
| Teng, Y | 1 |
| Zhang, G | 1 |
| Bi, H | 1 |
| Gao, J | 1 |
| Lu, X | 1 |
| Zheng, Y | 1 |
| Levy, JR | 1 |
| Murray, E | 1 |
| Manolagas, S | 1 |
| Olefsky, JM | 1 |
11 other studies available for chloroquine and Osteosarcoma
| Article | Year |
|---|---|
Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines.
Topics: Antineoplastic Agents, Phytogenic; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Surviv | 2022 |
Leptin acts on mesenchymal stem cells to promote chemoresistance in osteosarcoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Carcinogenesis; Chloroquine; Cisplatin; D | 2020 |
Targeting autophagy enhances atezolizumab-induced mitochondria-related apoptosis in osteosarcoma.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosi | 2021 |
Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3.
Topics: Adult; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Bone Neoplasms; Cell Proliferation; Ch | 2021 |
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagosomes; Autophagy; Cell Cycle Pro | 2017 |
Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Autophagy; Bone Neoplasms; Cell Line, Tumor; Cell Proliferat | 2019 |
Autophagy inhibitors regulate TRAIL sensitivity in human malignant cells by targeting the mitochondrial network and calcium dynamics.
Topics: Autophagy; Biomarkers, Tumor; Bone Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Su | 2019 |
Chloroquine blocks the autophagic process in cisplatin-resistant osteosarcoma cells by regulating the expression of p62/SQSTM1.
Topics: Adaptor Proteins, Signal Transducing; Autophagy; Cell Death; Cell Line, Tumor; Chloroquine; Cisplati | 2013 |
Chloroquine and valproic acid combined treatment in vitro has enhanced cytotoxicity in an osteosarcoma cell line.
Topics: Anticonvulsants; Antimalarials; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, | 2013 |
Inhibition of autophagy and enhancement of endoplasmic reticulum stress increase sensitivity of osteosarcoma Saos-2 cells to cannabinoid receptor agonist WIN55,212-2.
Topics: Adenine; Apoptosis; Autophagy; Benzoxazines; Cannabinoid Receptor Agonists; Cell Line, Tumor; Cell P | 2016 |
Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells.
Topics: Affinity Labels; Alkaline Phosphatase; Aminoisobutyric Acids; Animals; Binding, Competitive; Cell Li | 1986 |