Page last updated: 2024-10-24

chloroquine and Obesity

chloroquine has been researched along with Obesity in 12 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"The phytochemical sulforaphane (SFN) has been studied for its potential anti-obesity effect, but neither its molecular targets nor its interaction with the antimalarial drug chloroquine (CQ) has been fully delineated."8.12Chloroquine modulates the sulforaphane anti-obesity mechanisms in a high-fat diet model: Role of JAK-2/ STAT-3/ SOCS-3 pathway. ( Abdallah, DM; Ali, MA; Ashmawy, AI; El-Abhar, HS, 2022)
"Cardiotoxicity is a well-known side effect of chloroquine."3.91Revisiting the Cardiotoxic Effect of Chloroquine. ( Blignaut, M; Dhanabalan, K; Espach, Y; Huisamen, B; van Vuuren, M, 2019)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's4 (33.33)24.3611
2020's6 (50.00)2.80

Authors

AuthorsStudies
Ashmawy, AI1
El-Abhar, HS1
Abdallah, DM1
Ali, MA1
Chee, YJ1
Tan, SK1
Yeoh, E1
Watanabe, LM1
Pires, IF1
Noronha, NY1
Pinhel, MAS1
Nonino, CB1
Nachega, JB1
Ishoso, DK1
Otokoye, JO1
Hermans, MP1
Machekano, RN1
Sam-Agudu, NA1
Bongo-Pasi Nswe, C1
Mbala-Kingebeni, P1
Madinga, JN1
Mukendi, S1
KoliƩ, MC1
Nkwembe, EN1
Mbuyi, GM1
Nsio, JM1
Mukeba Tshialala, D1
Tshiasuma Pipo, M1
Ahuka-Mundeke, S1
Muyembe-Tamfum, JJ1
Mofenson, L1
Smith, G1
Mills, EJ1
Mellors, JW1
Zumla, A1
Mavungu Landu, DJ1
Kayembe, JM1
Huang, C1
Hsu, HJ1
Wang, ME1
Hsu, MC1
Wu, LS1
Jong, DS1
Jiang, YF1
Chiu, CH1
Zhang, S1
Zhu, H1
Ye, H1
Hu, Y1
Zheng, N1
Huang, Z1
Xiong, Z1
Fu, L1
Cai, T1
Gabriel, TL2
Mirzaian, M1
Hooibrink, B2
Ottenhoff, R1
van Roomen, C2
Aerts, JMFG1
van Eijk, M2
Blignaut, M1
Espach, Y1
van Vuuren, M1
Dhanabalan, K1
Huisamen, B1
Tol, MJ1
Ottenhof, R1
Aten, J1
Claessen, N1
de Weijer, B1
Serlie, MJ1
Argmann, C1
van Elsenburg, L1
Aerts, JM1
Mu, Y1
Yan, WJ1
Yin, TL1
Zhang, Y1
Li, J1
Yang, J1
Osman, MM1
Khalil, A1
Ahmed, MH1
Fischer, P1
Nostitz, HJ1

Reviews

1 review available for chloroquine and Obesity

ArticleYear
Dissecting the interaction between COVID-19 and diabetes mellitus.
    Journal of diabetes investigation, 2020, Volume: 11, Issue:5

    Topics: Antibodies, Monoclonal, Humanized; Antiviral Agents; Blood Glucose; Chloroquine; Comorbidity; COVID-

2020

Other Studies

11 other studies available for chloroquine and Obesity

ArticleYear
Chloroquine modulates the sulforaphane anti-obesity mechanisms in a high-fat diet model: Role of JAK-2/ STAT-3/ SOCS-3 pathway.
    European journal of pharmacology, 2022, Jul-15, Volume: 927

    Topics: Animals; Chloroquine; Diet, High-Fat; Isothiocyanates; Janus Kinase 2; Liver; Obesity; Random Alloca

2022
The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19.
    Clinics (Sao Paulo, Brazil), 2020, Volume: 75

    Topics: Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Obe

2020
Clinical Characteristics and Outcomes of Patients Hospitalized for COVID-19 in Africa: Early Insights from the Democratic Republic of the Congo.
    The American journal of tropical medicine and hygiene, 2020, Volume: 103, Issue:6

    Topics: Adolescent; Adult; Asymptomatic Diseases; Azithromycin; Chloroquine; COVID-19; COVID-19 Drug Treatme

2020
Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy.
    Scientific reports, 2021, 06-15, Volume: 11, Issue:1

    Topics: Animals; Autophagy; Chloroquine; Cholesterol Side-Chain Cleavage Enzyme; Endocrine Cells; Fatty Acid

2021
Risk factors for prolonged virus shedding of respiratory tract and fecal in adults with severe acute respiratory syndrome coronavirus-2 infection.
    Journal of clinical laboratory analysis, 2021, Volume: 35, Issue:9

    Topics: Adult; Animals; Antiviral Agents; CD4 Lymphocyte Count; Chloroquine; COVID-19; Feces; Female; Humans

2021
Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Adipose Tissue; Animals; CD11b Antigen; Cell Survival; Cells, Cultured; Chloroquine; Cluster Analysi

2017
Revisiting the Cardiotoxic Effect of Chloroquine.
    Cardiovascular drugs and therapy, 2019, Volume: 33, Issue:1

    Topics: Animals; Antimalarials; Cardiotoxicity; Cell Survival; Chloroquine; Dose-Response Relationship, Drug

2019
Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction.
    Diabetes, 2014, Volume: 63, Issue:10

    Topics: Adipose Tissue; Adult; Animals; Cell Nucleus; Cells, Cultured; Chloroquine; Female; Humans; Interleu

2014
Diet-induced obesity impairs spermatogenesis: a potential role for autophagy.
    Scientific reports, 2017, 03-09, Volume: 7

    Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Chloroquine; Diet, High-Fat; Humans; Infert

2017
Chloroquine-induced nitric oxide: new treatment for an emerging epidemic of obesity-related glomerulopathy.
    Diabetes technology & therapeutics, 2006, Volume: 8, Issue:6

    Topics: Antirheumatic Agents; Chloroquine; Glomerulonephritis; Humans; Nitric Oxide; Obesity

2006
[Progressive chronic polyarthritis and active body mass].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1971, Jan-15, Volume: 26, Issue:2

    Topics: Adipose Tissue; Adult; Arthritis, Rheumatoid; Body Weight; Chloroquine; Creatinine; Humans; Methods;

1971