chloroquine has been researched along with Neuroblastoma in 30 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria." | 7.80 | Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria. ( du Plessis, LH; Helena, C; Kotzé, AF; van Huysteen, E; Wiesner, L, 2014) |
| "Two lysosomotropic agents, ammonium chloride and chloroquine inhibit the infection of murine neuroblastoma cells by rabies virus." | 7.67 | Ammonium chloride and chloroquine inhibit rabies virus infection in neuroblastoma cells. Brief report. ( Superti, F; Tsiang, H, 1984) |
| "Treatment of ellipticine-sensitive UKF-NB-4 and ellipticine-resistant UKF-NB-4ELLI cells with ellipticine-induced cytoplasmic vacuolization and ellipticine is concentrated in these vacuoles." | 5.42 | Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells. ( Adam, V; Cerna, T; Doktorova, H; Eckschlager, T; Frei, E; Groh, T; Hrabeta, J; Khalil, MA; Kizek, R; Poljakova, J; Stiborova, M; Uhlik, J, 2015) |
| "Chloroquine was administered intraperitoneally at a dose of 40 mg/kg body weight for 10 of 14 treatment days." | 5.28 | The effect of chloroquine and hyperthermia on murine neuroblastoma. ( Faught, PR; Grosfeld, JL; Thomas, R; Vane, DW, 1990) |
| " Here, we analyze the effects of the broad-spectrum HDAC inhibitors (HDACi) panobinostat and vorinostat on the transcriptional regulation of autophagy with respect to autophagy transcription factor activity (Transcription factor EB-TFEB, forkhead boxO-FOXO) and autophagic flux in neuroblastoma cells." | 4.02 | Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma. ( Frese, K; Gerloff, XF; Körholz, K; Krunic, D; Meder, B; Najafi, S; Oehme, I; Peterziel, H; Ridinger, J; Vega-Rubin-de-Celis, S; Witt, O, 2021) |
| "Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria." | 3.80 | Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria. ( du Plessis, LH; Helena, C; Kotzé, AF; van Huysteen, E; Wiesner, L, 2014) |
| "Addition of 50 micrograms/ml chloroquine to neuroblastoma cells 1 h before infection with temperature-sensitive mutant ts G31 (III) of vesicular stomatitis virus (VSV) prevented virus-induced cell fusion from occurring." | 3.66 | Inhibition of vesicular stomatitis virus glycoprotein expression by chloroquine. ( Dille, BJ; Johnson, TC, 1982) |
| "Treatment of ellipticine-sensitive UKF-NB-4 and ellipticine-resistant UKF-NB-4ELLI cells with ellipticine-induced cytoplasmic vacuolization and ellipticine is concentrated in these vacuoles." | 1.42 | Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells. ( Adam, V; Cerna, T; Doktorova, H; Eckschlager, T; Frei, E; Groh, T; Hrabeta, J; Khalil, MA; Kizek, R; Poljakova, J; Stiborova, M; Uhlik, J, 2015) |
| "Treatment with methylamine and ammonium chloride, inhibitors interfering with intracellular transport mechanisms, inhibits beta-secretase activity without influencing the physiological APP cleavage by alpha-secretase activity." | 1.29 | Inhibition of beta A4 production by specific modulation of beta-secretase activity. ( Beyreuther, K; Czech, C; Dyrks, T; Reinsch, C; Turner, J; Urmoneit, B, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (23.33) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 1 (3.33) | 29.6817 |
| 2010's | 11 (36.67) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kommalapati, VK | 1 |
| Kumar, D | 1 |
| Tangutur, AD | 1 |
| Corallo, D | 1 |
| Pastorino, F | 1 |
| Pantile, M | 1 |
| Mariotto, E | 1 |
| Caicci, F | 1 |
| Viola, G | 1 |
| Ponzoni, M | 1 |
| Tonini, GP | 1 |
| Aveic, S | 1 |
| Körholz, K | 1 |
| Ridinger, J | 1 |
| Krunic, D | 1 |
| Najafi, S | 1 |
| Gerloff, XF | 1 |
| Frese, K | 1 |
| Meder, B | 1 |
| Peterziel, H | 1 |
| Vega-Rubin-de-Celis, S | 1 |
| Witt, O | 1 |
| Oehme, I | 1 |
| Liang, Y | 1 |
| Zhou, T | 1 |
| Chen, Y | 1 |
| Lin, D | 1 |
| Jing, X | 1 |
| Peng, S | 1 |
| Zheng, D | 1 |
| Zeng, Z | 1 |
| Lei, M | 1 |
| Wu, X | 1 |
| Huang, K | 1 |
| Yang, L | 1 |
| Xiao, S | 1 |
| Liu, J | 1 |
| Tao, E | 1 |
| Zarei, H | 1 |
| Kazemi Oskuee, R | 1 |
| Hanafi-Bojd, MY | 1 |
| Gholami, L | 1 |
| Ansari, L | 1 |
| Malaekeh-Nikouei, B | 1 |
| Rodrigo, MAM | 1 |
| Buchtelova, H | 1 |
| Jimenez, AMJ | 1 |
| Adam, P | 1 |
| Babula, P | 1 |
| Heger, Z | 1 |
| Adam, V | 2 |
| Hui, L | 1 |
| Ye, Y | 1 |
| Soliman, ML | 1 |
| Lakpa, KL | 1 |
| Miller, NM | 1 |
| Afghah, Z | 1 |
| Geiger, JD | 1 |
| Chen, X | 1 |
| du Plessis, LH | 1 |
| Helena, C | 1 |
| van Huysteen, E | 1 |
| Wiesner, L | 1 |
| Kotzé, AF | 1 |
| Alquezar, C | 1 |
| Esteras, N | 1 |
| de la Encarnación, A | 1 |
| Moreno, F | 1 |
| López de Munain, A | 1 |
| Martín-Requero, Á | 1 |
| Pajuelo-Reguera, D | 1 |
| Alán, L | 1 |
| Olejár, T | 1 |
| Ježek, P | 1 |
| Hrabeta, J | 1 |
| Groh, T | 1 |
| Khalil, MA | 1 |
| Poljakova, J | 1 |
| Kizek, R | 1 |
| Uhlik, J | 1 |
| Doktorova, H | 1 |
| Cerna, T | 1 |
| Frei, E | 1 |
| Stiborova, M | 1 |
| Eckschlager, T | 1 |
| Wilson, SR | 1 |
| Gerhold, KA | 1 |
| Bifolck-Fisher, A | 1 |
| Liu, Q | 1 |
| Patel, KN | 1 |
| Dong, X | 1 |
| Bautista, DM | 1 |
| Travelli, C | 1 |
| Drago, V | 1 |
| Maldi, E | 1 |
| Kaludercic, N | 1 |
| Galli, U | 1 |
| Boldorini, R | 1 |
| Di Lisa, F | 1 |
| Tron, GC | 1 |
| Canonico, PL | 1 |
| Genazzani, AA | 1 |
| Cagnin, M | 1 |
| Ozzano, M | 1 |
| Bellio, N | 1 |
| Fiorentino, I | 1 |
| Follo, C | 1 |
| Isidoro, C | 1 |
| Seitz, C | 1 |
| Hugle, M | 1 |
| Cristofanon, S | 1 |
| Tchoghandjian, A | 1 |
| Fulda, S | 1 |
| Tsiang, H | 1 |
| Superti, F | 1 |
| Dille, BJ | 2 |
| Hughes, JV | 1 |
| Johnson, TC | 2 |
| Rabinowitz, SG | 1 |
| Dal Canto, MC | 1 |
| Waechter, CJ | 1 |
| Schmidt, JW | 1 |
| Catterall, WA | 1 |
| Law, PY | 1 |
| Hom, DS | 1 |
| Loh, HH | 1 |
| Fuller, SJ | 1 |
| Storey, E | 1 |
| Li, QX | 1 |
| Smith, AI | 1 |
| Beyreuther, K | 2 |
| Masters, CL | 1 |
| Suárez, N | 1 |
| Eriksson, H | 1 |
| Urmoneit, B | 1 |
| Reinsch, C | 1 |
| Turner, J | 1 |
| Czech, C | 1 |
| Dyrks, T | 1 |
| Hari, T | 1 |
| Bütikofer, P | 1 |
| Wiesmann, UN | 1 |
| Brodbeck, U | 1 |
| Shapira, M | 1 |
| Keren, O | 1 |
| Gafni, M | 1 |
| Sarne, Y | 1 |
| Passafaro, M | 1 |
| Clementi, F | 1 |
| Sher, E | 1 |
| Donovan, MG | 1 |
| Storm, DR | 1 |
| Thomas, R | 1 |
| Vane, DW | 1 |
| Grosfeld, JL | 1 |
| Faught, PR | 1 |
| Klein, C | 1 |
| Levy, R | 1 |
| Simantov, R | 1 |
| Heidenreich, KA | 1 |
| Gilmore, PR | 1 |
30 other studies available for chloroquine and Neuroblastoma
| Article | Year |
|---|---|
Inhibition of JNJ-26481585-mediated autophagy induces apoptosis via ROS activation and mitochondrial membrane potential disruption in neuroblastoma cells.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Caspase 3; Cel | 2020 |
Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib.
Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Dru | 2020 |
Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma.
Topics: Animals; Antimalarials; Autophagy; Chloroquine; Forkhead Box Protein O1; Forkhead Box Protein O3; Ge | 2021 |
Rifampicin inhibits rotenone-induced microglial inflammation via enhancement of autophagy.
Topics: Analysis of Variance; Antirheumatic Agents; Autophagy; Cell Line, Tumor; Chloroquine; Coculture Tech | 2017 |
Enhanced gene delivery by polyethyleneimine coated mesoporous silica nanoparticles.
Topics: Animals; Cell Line, Tumor; Chloroquine; DNA; Gene Expression Regulation; Gene Transfer Techniques; G | 2019 |
Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells.
Topics: Cell Line, Tumor; Cell Shape; Chloroquine; Cisplatin; Clone Cells; Drug Resistance, Neoplasm; Gene E | 2019 |
Antiretroviral Drugs Promote Amyloidogenesis by De-Acidifying Endolysosomes.
Topics: Amyloid; Amyloid beta-Peptides; Amyloidosis; Animals; Anti-HIV Agents; Cell Line, Tumor; Cells, Cult | 2021 |
Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria.
Topics: Animals; Biological Availability; Cell Line, Tumor; Chemistry, Pharmaceutical; Chloroquine; Coated V | 2014 |
Increasing progranulin levels and blockade of the ERK1/2 pathway: upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia.
Topics: Aged; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chloroquine; DNA-Binding Pr | 2015 |
Dichloroacetate stimulates changes in the mitochondrial network morphology via partial mitophagy in human SH-SY5Y neuroblastoma cells.
Topics: Autophagy; Cell Line, Tumor; Cell Survival; Chloroquine; Dichloroacetic Acid; DNA Copy Number Variat | 2015 |
Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chloroquine; DNA Adducts; Drug Resistance, Neopl | 2015 |
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antirheumatic Agents; Calcium; Capsaicin; Cells, Cu | 2011 |
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells.
Topics: Acrylamides; Adenosine; Adenosine Triphosphate; Annexin A5; Antineoplastic Agents; Antineoplastic Ag | 2011 |
Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals | 2012 |
The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk.
Topics: Antimalarials; Apoptosis; Autophagy; bcl-2-Associated X Protein; Blotting, Western; Cell Membrane Pe | 2013 |
Ammonium chloride and chloroquine inhibit rabies virus infection in neuroblastoma cells. Brief report.
Topics: Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Endocytosis; Endosomes; Lysosomes; Mice; N | 1984 |
Cytopathic effects in mouse neuroblastoma cells during a non-permissive infection with a mutant of vesicular stomatitis virus.
Topics: Animals; Cell Fusion; Cell Line; Chloroquine; Cycloheximide; Cytopathogenic Effect, Viral; Dactinomy | 1981 |
Inhibition of vesicular stomatitis virus glycoprotein expression by chloroquine.
Topics: Animals; Cell Fusion; Cell Line; Cell Membrane; Chloroquine; Glycoproteins; Mice; Neuroblastoma; Tun | 1982 |
Glycosylation is required for maintenance of functional sodium channels in neuroblastoma cells.
Topics: Amphibian Proteins; Animals; Carbohydrate Metabolism; Carrier Proteins; Cell Line; Chloroquine; Ion | 1983 |
Down-regulation of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Chloroquine promotes accumulation of tritiated enkephalin in the lysosomes.
Topics: Animals; Cell Line; Chloroquine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid | 1984 |
Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein.
Topics: Alzheimer Disease; Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid | 1995 |
Receptor-mediated endocytosis of a manganese complex of transferrin into neuroblastoma (SHSY5Y) cells in culture.
Topics: Chloroquine; Cold Temperature; Endocytosis; Humans; Manganese; Neuroblastoma; Precipitin Tests; Pron | 1993 |
Inhibition of beta A4 production by specific modulation of beta-secretase activity.
Topics: Ammonium Chloride; Amyloid; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Ac | 1995 |
Uptake and intracellular stability of glycosylphosphatidylinositol-specific phospholipase D in neuroblastoma cells.
Topics: Animals; Cattle; Chloroquine; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Stability; | 1997 |
Divers pathways mediate delta-opioid receptor down regulation within the same cell.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Cysteine Proteinase | 2001 |
Metabolism of omega-conotoxin-sensitive voltage-operated calcium channels in human neuroblastoma cells: modulation by cell differentiation and anti-channel antibodies.
Topics: Antibodies; Calcium Channels; Cell Differentiation; Chloroquine; Electrophysiology; Humans; Leupepti | 1992 |
Evidence that the adenylate cyclase secreted from Bordetella pertussis does not enter animal cells by receptor-mediated endocytosis.
Topics: Adenylyl Cyclases; Ammonium Chloride; Animals; Biological Transport; Bordetella pertussis; Cell Line | 1990 |
The effect of chloroquine and hyperthermia on murine neuroblastoma.
Topics: Animals; Chloroquine; Combined Modality Therapy; Hyperthermia, Induced; Male; Mice; Neoplasm Transpl | 1990 |
Subcellular compartmentation of opioid receptors: modulation by enkephalin and alkaloids.
Topics: Animals; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Chloroquine; Diprenorphine; Enk | 1986 |
Structural and functional characteristics of insulin receptors in rat neuroblastoma cells.
Topics: Animals; Biological Transport, Active; Cell Line; Chloroquine; Deoxyglucose; Insulin; Kinetics; Neur | 1985 |