chloroquine has been researched along with Neural Tube Defects in 1 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| " It also appears that although the individual enantiomers show minimal embryotoxicity at the dosage used, they potentiate each other's effects in the racemic mixture." | 1.29 | Effects of chloroquine and its enantiomers on the development of rat embryos in vitro. ( Ofori-Adjei, D; Tagoe, CN, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tagoe, CN | 1 |
| Ofori-Adjei, D | 1 |
1 other study available for chloroquine and Neural Tube Defects
| Article | Year |
|---|---|
Effects of chloroquine and its enantiomers on the development of rat embryos in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Anthropometry; Antimalarials; Chloroquine; Embryo, Mammalian; | 1995 |