chloroquine has been researched along with Nervous System Diseases in 15 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the efficacy of chloroquine (Aralen) phosphate and hydroxychloroquine (Plaquenil) sulfate in the treatment of patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects." | 7.70 | Effectiveness of chloroquine and hydroxychloroquine in treating selected patients with sarcoidosis with neurological involvement. ( Sharma, OP, 1998) |
| "To compare the frequency of adverse events, particularly neuropsychiatric effects, from mefloquine and from chloroquine plus proguanil as used for malaria chemoprophylaxis." | 7.69 | Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers. ( Barrett, PJ; Bradley, DJ; Clarke, PD; Emmins, PD, 1996) |
| " Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), rheumatological (systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, Sjögren's syndrome), and other immunological diseases." | 4.98 | Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review. ( Koudriavtseva, T; Plantone, D, 2018) |
| "To assess the efficacy of chloroquine (Aralen) phosphate and hydroxychloroquine (Plaquenil) sulfate in the treatment of patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects." | 3.70 | Effectiveness of chloroquine and hydroxychloroquine in treating selected patients with sarcoidosis with neurological involvement. ( Sharma, OP, 1998) |
| "To compare the frequency of adverse events, particularly neuropsychiatric effects, from mefloquine and from chloroquine plus proguanil as used for malaria chemoprophylaxis." | 3.69 | Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers. ( Barrett, PJ; Bradley, DJ; Clarke, PD; Emmins, PD, 1996) |
| "A marked cutaneous axonal dystrophy has been observed electronmicroscopically for the first time in the skin of three patients: (a) lesion of pityriasis lichenoides chronica in a patient with bronchogenic carcinoma, (b) non involved skin of a patient with malignant melanoma and (c) non involved skin of a patient with gout and retinal damage after prolonged use of chloroquine." | 3.65 | [Tumor- and drug-induced cutaneous axonal dystrophy. An electronmicrocopy proof of multiple lamellated bodies]. ( Orfanos, CE; Runne, U, 1975) |
| " A stepwise multiple regression analysis was used to evaluate the dose-response relationship between the registered data on one hand and solvent exposure, employment on chemical tankers, age, alcohol and chloroquine phosphate consumption on the other." | 1.27 | Seamen exposed to organic solvents. A cross-sectional study with special reference to the nervous system. ( Fossan, GO; Moen, BE; Riise, T; Todnem, K, 1988) |
| "Chloroquine is a neuromyotoxin that affects nerves and cardiac and skeletal muscles." | 1.27 | Chloroquine neuromyotoxicity. Clinical and pathologic perspective. ( Chou, SM; Estes, ML; Ewing-Wilson, D; Hanson, M; Mitsumoto, H; Ratliff, NB; Shirey, E, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Plantone, D | 1 |
| Koudriavtseva, T | 1 |
| Adonis-Koffy, L | 1 |
| Daubrey, T | 1 |
| Kouadio, A | 1 |
| Timité-Konan, AM | 1 |
| Kabran, J | 1 |
| Bischoff, A | 1 |
| Barrett, PJ | 1 |
| Emmins, PD | 1 |
| Clarke, PD | 1 |
| Bradley, DJ | 1 |
| Sharma, OP | 1 |
| Runne, U | 1 |
| Orfanos, CE | 1 |
| Klinghardt, GW | 2 |
| Miyata, M | 1 |
| Mayer, K | 1 |
| Moen, BE | 1 |
| Riise, T | 1 |
| Todnem, K | 1 |
| Fossan, GO | 1 |
| Havens, PL | 1 |
| Splaingard, ML | 1 |
| Bousounis, D | 1 |
| Hoffman, GM | 1 |
| Estes, ML | 1 |
| Ewing-Wilson, D | 1 |
| Chou, SM | 1 |
| Mitsumoto, H | 1 |
| Hanson, M | 1 |
| Shirey, E | 1 |
| Ratliff, NB | 1 |
| Erringer, A | 1 |
| Colville, P | 1 |
| Mikula, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Proflaxis for Healthcare Professionals Using Hydroxychloroquine Plus Vitamin Combining Vitamins C, D and Zinc During COVID-19 Pandemia: An Observational Study[NCT04326725] | 80 participants (Anticipated) | Observational | 2020-03-20 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chloroquine and Nervous System Diseases
| Article | Year |
|---|---|
Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antimalarials; Antineoplastic Agents; Antirheumatic | 2018 |
Experimental neuropathology and clinical neurology of chloroquine side effects.
Topics: Animals; Axons; Chloroquine; Cytoplasmic Granules; Dose-Response Relationship, Drug; Ganglia, Spinal | 1978 |
13 other studies available for chloroquine and Nervous System Diseases
| Article | Year |
|---|---|
[Misunderstood neurological side effects of amodiaquine: apropos of 35 cases in children at Central University Hospital of Yopougon at Abidjan, Côte d' Ivoire].
Topics: Adolescent; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Cote d'Ivoire; Drug Re | 2003 |
Clinical and experimental work in neurotoxicity.
Topics: Animals; Axons; Chickens; Chloroquine; Cresols; Humans; Lysosomes; Male; Models, Biological; Nervous | 1980 |
Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers.
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Health Surveys; Hospitalizatio | 1996 |
Effectiveness of chloroquine and hydroxychloroquine in treating selected patients with sarcoidosis with neurological involvement.
Topics: Adult; Antimalarials; Brain; Chloroquine; Female; Humans; Hydroxychloroquine; Magnetic Resonance Ima | 1998 |
[Tumor- and drug-induced cutaneous axonal dystrophy. An electronmicrocopy proof of multiple lamellated bodies].
Topics: Adult; Aged; Axons; Bronchial Neoplasms; Chloroquine; Cytoplasm; Drug Hypersensitivity; Female; Gout | 1975 |
[Neurolo-toxicological disorders and retinal pigmentary degeneration].
Topics: Chloroquine; Humans; Nervous System Diseases; Phenothiazines; Retinal Degeneration | 1978 |
[Neurogenic symptoms for the early diagnosis of adverse drug effects].
Topics: Anti-Bacterial Agents; Anticoagulants; Basal Ganglia Diseases; Chloroquine; Cortisone; Depression; D | 1976 |
Seamen exposed to organic solvents. A cross-sectional study with special reference to the nervous system.
Topics: Chloroquine; Cross-Sectional Studies; Environmental Exposure; Ethanol; Humans; Male; Naval Medicine; | 1988 |
Survival after chloroquine ingestion in a child.
Topics: Brain Edema; Chloroquine; Coma; Electroencephalography; Evoked Potentials; Humans; Infant; Male; Ner | 1988 |
Chloroquine neuromyotoxicity. Clinical and pathologic perspective.
Topics: Aged; Biopsy; Cardiomyopathies; Chloroquine; Female; Humans; Hydroxychloroquine; Male; Middle Aged; | 1987 |
[Experimental lesions of the nervous and muscular systems due to chloroquine: models of various storage dystrophies (author's transl)].
Topics: Animals; Chloroquine; Chromatography, Thin Layer; Disease Models, Animal; Germ-Free Life; Glycogen S | 1974 |
Chloroquine neuromyopathy associated with keratopathy and retinopathy.
Topics: Chloroquine; Corneal Dystrophies, Hereditary; Eye Diseases; Female; Humans; Middle Aged; Muscular Di | 1967 |
[Therapeutic use of chloroquine in neurology].
Topics: Chloroquine; Humans; Nervous System Diseases | 1966 |