chloroquine has been researched along with Nerve Sheath Neoplasms in 2 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Nerve Sheath Neoplasms: Neoplasms which arise from nerve sheaths formed by SCHWANN CELLS in the PERIPHERAL NERVOUS SYSTEM or by OLIGODENDROCYTES in the CENTRAL NERVOUS SYSTEM. Malignant peripheral nerve sheath tumors, NEUROFIBROMA, and NEURILEMMOMA are relatively common tumors in this category.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Combined chloroquine and HDACi treatment abrogates growth of human MPNST xenografts and lung metastases." | 3.77 | Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: potential implications for the treatment of a therapeutic-resistant malignancy. ( Lev, D; Lopez, G; Torres, K, 2011) |
| "Malignant peripheral nerve sheath tumors (MPNSTs) are rapidly progressive Schwann cell neoplasms." | 1.38 | The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells. ( Byer, S; Carroll, SL; Kaza, N; Kohli, L; Lavalley, NJ; Roth, KA; Turner, KL, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lopez, G | 1 |
| Torres, K | 1 |
| Lev, D | 1 |
| Kohli, L | 1 |
| Kaza, N | 1 |
| Lavalley, NJ | 1 |
| Turner, KL | 1 |
| Byer, S | 1 |
| Carroll, SL | 1 |
| Roth, KA | 1 |
2 other studies available for chloroquine and Nerve Sheath Neoplasms
| Article | Year |
|---|---|
Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: potential implications for the treatment of a therapeutic-resistant malignancy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Chloroquine; Gene Expression Regulation, Neopl | 2011 |
The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Ce | 2012 |