chloroquine has been researched along with Nerve Degeneration in 7 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine sulphate was found to be highly toxic when administered in single doses in excess of 40 mg/kg." | 1.27 | The ototoxicity of chloroquine sulphate in the guinea pig. ( Sykes, H, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, W | 1 |
| Guo, Y | 1 |
| Yang, W | 1 |
| Zheng, P | 1 |
| Zeng, J | 1 |
| Tong, W | 1 |
| Wang, C | 1 |
| Liang, CC | 1 |
| Bian, ZC | 1 |
| Zhu, Y | 1 |
| Guan, JL | 1 |
| Viscomi, MT | 1 |
| D'Amelio, M | 1 |
| Cavallucci, V | 1 |
| Latini, L | 1 |
| Bisicchia, E | 1 |
| Nazio, F | 1 |
| Fanelli, F | 1 |
| Maccarrone, M | 1 |
| Moreno, S | 1 |
| Cecconi, F | 1 |
| Molinari, M | 1 |
| Sykes, H | 1 |
| Holmin, S | 1 |
| Mathiesen, T | 1 |
| Tegnér, R | 1 |
| Tomé, FM | 1 |
| Godeau, P | 1 |
| Lhermitte, F | 1 |
| Fardeau, M | 1 |
| Gérard, JM | 1 |
| Stoupel, N | 1 |
| Collier, A | 1 |
| Flament-Durand, J | 1 |
7 other studies available for chloroquine and Nerve Degeneration
| Article | Year |
|---|---|
Involvement of autophagy in connexin 40 reduction in the late phase of traumatic brain injury in rats.
Topics: Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Brain; Brain Injuries; Brain Injuries | 2017 |
FIP200 is required for maintenance and differentiation of postnatal neural stem cells.
Topics: Acetylcysteine; Age Factors; Animals; Animals, Newborn; Apoptosis; Autophagy; Autophagy-Related Prot | 2013 |
Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Axotomy; Beclin-1; Brain Injuries; Cerebellum; Ch | 2012 |
The ototoxicity of chloroquine sulphate in the guinea pig.
Topics: Animals; Chloroquine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hair Cells, Auditory; M | 1984 |
Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Concussion; Brain Damage, Chronic; Brain Edema; Chlo | 1996 |
Morphological study of peripheral nerve changes induced by chloroquine treatment.
Topics: Adult; Biopsy; Chloroquine; Demyelinating Diseases; Female; Humans; Male; Middle Aged; Nerve Degener | 1988 |
Morphologic study of a neuromyopathy caused by prolonged chloroquine treatment.
Topics: Action Potentials; Chloroquine; Electromyography; Female; Humans; Lupus Erythematosus, Discoid; Micr | 1973 |