chloroquine has been researched along with Nasopharyngeal Carcinoma in 5 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Nasopharyngeal Carcinoma: A carcinoma that originates in the EPITHELIUM of the NASOPHARYNX and includes four subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations associated with this cancer have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the role of miR129 in mediating the effect of chloroquine to enhance cisplatin- induced apoptosis in nasopharyngeal carcinoma cells (HNE1)." | 7.96 | [Chloroquine enhances cisplatin-induced apoptosis of nasopharyngeal carcinoma cells by inhibiting autophagy via upregulating miR129]. ( Cai, W; Fang, Y; He, R; Lu, H; Pei, F; Wang, X; Wei, F; Yu, Y; Zhang, H; Zhang, R, 2020) |
| "We investigated the effect of chloroquine, a known inhibitor of autophagy, on sensitization against radiation-induced apoptosis in a panel of five nasopharyngeal carcinoma cell lines and a SV40-transformed nasoepithelial cell line." | 7.83 | Chloroquine Sensitizes Nasopharyngeal Carcinoma Cells but Not Nasoepithelial Cells to Irradiation by Blocking Autophagy. ( Eble, M; Hoß, M; Kontny, U; Makowska, A; Prescher, K, 2016) |
| "To investigate the role of miR129 in mediating the effect of chloroquine to enhance cisplatin- induced apoptosis in nasopharyngeal carcinoma cells (HNE1)." | 3.96 | [Chloroquine enhances cisplatin-induced apoptosis of nasopharyngeal carcinoma cells by inhibiting autophagy via upregulating miR129]. ( Cai, W; Fang, Y; He, R; Lu, H; Pei, F; Wang, X; Wei, F; Yu, Y; Zhang, H; Zhang, R, 2020) |
| "We investigated the effect of chloroquine, a known inhibitor of autophagy, on sensitization against radiation-induced apoptosis in a panel of five nasopharyngeal carcinoma cell lines and a SV40-transformed nasoepithelial cell line." | 3.83 | Chloroquine Sensitizes Nasopharyngeal Carcinoma Cells but Not Nasoepithelial Cells to Irradiation by Blocking Autophagy. ( Eble, M; Hoß, M; Kontny, U; Makowska, A; Prescher, K, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Yu, Y | 1 |
| Cai, W | 1 |
| Lu, H | 1 |
| He, R | 1 |
| Zhang, R | 1 |
| Pei, F | 1 |
| Wang, X | 1 |
| Fang, Y | 1 |
| Wei, F | 1 |
| Li, Q | 1 |
| Wang, M | 1 |
| Zhang, Y | 1 |
| Wang, L | 1 |
| Yu, W | 1 |
| Bao, X | 1 |
| Zhang, B | 1 |
| Xiang, Y | 1 |
| Deng, A | 1 |
| Aga, T | 1 |
| Endo, K | 1 |
| Tsuji, A | 1 |
| Aga, M | 1 |
| Moriyama-Kita, M | 1 |
| Ueno, T | 1 |
| Nakanishi, Y | 1 |
| Hatano, M | 1 |
| Kondo, S | 1 |
| Sugimoto, H | 1 |
| Wakisaka, N | 1 |
| Yoshizaki, T | 1 |
| Zhou, ZR | 1 |
| Zhu, XD | 1 |
| Zhao, W | 1 |
| Qu, S | 1 |
| Su, F | 1 |
| Huang, ST | 1 |
| Ma, JL | 1 |
| Li, XY | 1 |
| Makowska, A | 1 |
| Eble, M | 1 |
| Prescher, K | 1 |
| Hoß, M | 1 |
| Kontny, U | 1 |
5 other studies available for chloroquine and Nasopharyngeal Carcinoma
| Article | Year |
|---|---|
[Chloroquine enhances cisplatin-induced apoptosis of nasopharyngeal carcinoma cells by inhibiting autophagy via upregulating miR129].
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroqu | 2020 |
BIX-01294-enhanced chemosensitivity in nasopharyngeal carcinoma depends on autophagy-induced pyroptosis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Autophagy-Related Protein 5; Aze | 2020 |
Inhibition of autophagy by chloroquine makes chemotherapy in nasopharyngeal carcinoma more efficient.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Cell Line, Tumor; Ce | 2019 |
Poly(ADP-ribose) polymerase-1 regulates the mechanism of irradiation-induced CNE-2 human nasopharyngeal carcinoma cell autophagy and inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Benzamides; Carcinoma; Cell Line, Tumor; Cell Survival; | 2013 |
Chloroquine Sensitizes Nasopharyngeal Carcinoma Cells but Not Nasoepithelial Cells to Irradiation by Blocking Autophagy.
Topics: Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Autophagy-Related Pr | 2016 |