chloroquine has been researched along with Muscular Atrophy, Spinal in 2 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Muscular Atrophy, Spinal: A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gopalsamy, A | 1 |
| Narayanan, A | 1 |
| Liu, S | 1 |
| Parikh, MD | 1 |
| Kyne, RE | 1 |
| Fadeyi, O | 1 |
| Tones, MA | 1 |
| Cherry, JJ | 2 |
| Nabhan, JF | 1 |
| LaRosa, G | 1 |
| Petersen, DN | 1 |
| Menard, C | 1 |
| Foley, TL | 1 |
| Noell, S | 1 |
| Ren, Y | 1 |
| Loria, PM | 1 |
| Maglich-Goodwin, J | 1 |
| Rong, H | 1 |
| Jones, LH | 1 |
| Rietz, A | 1 |
| Li, H | 1 |
| Quist, KM | 1 |
| Lorson, CL | 1 |
| Burnett, BG | 1 |
| Kern, NL | 1 |
| Calder, AN | 1 |
| Fritsche, M | 1 |
| Lusic, H | 1 |
| Boaler, PJ | 1 |
| Choi, S | 1 |
| Xing, X | 1 |
| Glicksman, MA | 1 |
| Cuny, GD | 1 |
| Androphy, EJ | 1 |
| Hodgetts, KJ | 1 |
2 other studies available for chloroquine and Muscular Atrophy, Spinal
| Article | Year |
|---|---|
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Topics: Animals; Disease Models, Animal; Drug Design; Endoribonucleases; Enzyme Inhibitors; HEK293 Cells; Hu | 2017 |
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.
Topics: Anilides; Area Under Curve; Benzamides; Cell Line; Drug Discovery; Half-Life; Humans; Isoxazoles; Mo | 2017 |