chloroquine has been researched along with Muscle Relaxation in 11 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, chronic use of β-agonists to treat asthma is associated with desensitization of β-agonist signaling and a resultant loss of bronchodilator effect, worsening of airway hyperreactivity, and increased incidence of asthma-related morbidity and mortality." | 1.38 | Future bronchodilator therapy: a bitter pill to swallow? ( Clifford, RL; Knox, AJ, 2012) |
| " Acute and chronic administration of Chlo (45 mg kg-1, i." | 1.28 | Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro. ( Okwuasaba, FK; Otubu, JA; Udoh, FV, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (90.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jing, F | 1 |
| Liu, M | 1 |
| Yang, N | 1 |
| Liu, Y | 1 |
| Li, X | 1 |
| Li, J | 1 |
| Tan, X | 1 |
| Sanderson, MJ | 1 |
| Zhang, T | 1 |
| Luo, XJ | 1 |
| Sai, WB | 1 |
| Yu, MF | 1 |
| Li, WE | 1 |
| Ma, YF | 1 |
| Chen, W | 1 |
| Zhai, K | 1 |
| Qin, G | 1 |
| Guo, D | 1 |
| Zheng, YM | 1 |
| Wang, YX | 1 |
| Shen, JH | 1 |
| Ji, G | 1 |
| Liu, QH | 1 |
| Manson, ML | 2 |
| Säfholm, J | 2 |
| Al-Ameri, M | 1 |
| Bergman, P | 1 |
| Orre, AC | 1 |
| Swärd, K | 1 |
| James, A | 1 |
| Dahlén, SE | 2 |
| Adner, M | 2 |
| Camoretti-Mercado, B | 1 |
| Pauer, SH | 1 |
| Yong, HM | 2 |
| Smith, DC | 1 |
| Deshpande, DA | 1 |
| An, SS | 3 |
| Liggett, SB | 2 |
| Mikami, M | 1 |
| Zhang, Y | 1 |
| Danielsson, J | 1 |
| Joell, T | 1 |
| Townsend, E | 1 |
| Khurana, S | 1 |
| Emala, CW | 1 |
| Belvisi, MG | 1 |
| Dale, N | 1 |
| Birrell, MA | 1 |
| Canning, BJ | 1 |
| Wang, WC | 1 |
| Koziol-White, CJ | 1 |
| Ahn, K | 1 |
| Lee, DY | 1 |
| Kurten, RC | 1 |
| Panettieri, RA | 1 |
| Pulkkinen, V | 1 |
| Clifford, RL | 1 |
| Knox, AJ | 1 |
| Okwuasaba, FK | 1 |
| Otubu, JA | 1 |
| Udoh, FV | 1 |
11 other studies available for chloroquine and Muscle Relaxation
| Article | Year |
|---|---|
Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa.
Topics: Animals; Calcium; Chloroquine; Enzyme Inhibitors; Gastrointestinal Motility; Ileum; Intestinal Mucos | 2013 |
Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.
Topics: Airway Resistance; Animals; Bronchodilator Agents; Caffeine; Calcium Channel Blockers; Calcium Signa | 2014 |
Non-selective cation channels mediate chloroquine-induced relaxation in precontracted mouse airway smooth muscle.
Topics: Acetylcholine; Action Potentials; Animals; Antirheumatic Agents; Calcium; Calcium Channels, L-Type; | 2014 |
Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle.
Topics: Aged; Animals; Aorta, Thoracic; Chloroquine; Colon; Dextromethorphan; Female; Guinea Pigs; Humans; I | 2014 |
Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells.
Topics: Action Potentials; Aristolochic Acids; Calcium Signaling; Cells, Cultured; Chloroquine; Endothelin-1 | 2015 |
Impaired Relaxation of Airway Smooth Muscle in Mice Lacking the Actin-Binding Protein Gelsolin.
Topics: Actins; Animals; Biomechanical Phenomena; Cell Separation; Chloroquine; Electric Impedance; Gelsolin | 2017 |
Bronchodilator activity of bitter tastants in human tissue.
Topics: Animals; Bronchi; Bronchodilator Agents; Chloroquine; Dose-Response Relationship, Drug; Guinea Pigs; | 2011 |
TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Chloroquine; Humans; In Vitro Techniques; Isoprotereno | 2012 |
The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.
Topics: Albuterol; Animals; Bronchodilator Agents; Carbachol; Charybdotoxin; Chloroquine; Cholinergic Agonis | 2012 |
Future bronchodilator therapy: a bitter pill to swallow?
Topics: Animals; Bronchodilator Agents; Chloroquine; Humans; Male; Muscle Relaxation; Muscle, Smooth; Quater | 2012 |
Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro.
Topics: Animals; Caffeine; Calcium; Chloroquine; Dantrolene; Diaphragm; Electric Stimulation; Female; In Vit | 1990 |