chloroquine has been researched along with Muscle Contraction in 32 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The pKB values obtained from the initial parallel shift of the dose-response curves for histamine in the presence of these drugs were 5." | 1.30 | Interaction of local anaesthetics with histamine H1 receptors in guinea-pig ileum. ( Horio, S; Ishida, Y; Moritoki, H; Nagare, T, 1997) |
| "The functional effects on chick smooth and skeletal muscle of chronic administration of 60 mg kg-1 chloroquine or quinacrine given as daily intraperitoneal injections for 70 days have been investigated." | 1.28 | Smooth muscle sensitization and neuromuscular depression induced by chronic administration of antimalarial drugs. ( Lot, TY, 1992) |
| " Acute and chronic administration of Chlo (45 mg kg-1, i." | 1.28 | Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro. ( Okwuasaba, FK; Otubu, JA; Udoh, FV, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (56.25) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 7 (21.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hirasawa, Y | 1 |
| Arai, H | 1 |
| Zaima, K | 1 |
| Oktarina, R | 1 |
| Rahman, A | 1 |
| Ekasari, W | 1 |
| Widyawaruyanti, A | 1 |
| Indrayanto, G | 1 |
| Zaini, NC | 1 |
| Morita, H | 1 |
| Zheng, K | 1 |
| Lu, P | 1 |
| Delpapa, E | 1 |
| Bellve, K | 1 |
| Deng, R | 1 |
| Condon, JC | 1 |
| Fogarty, K | 1 |
| Lifshitz, LM | 1 |
| Simas, TAM | 1 |
| Shi, F | 1 |
| ZhuGe, R | 1 |
| Campos, JC | 1 |
| Baehr, LM | 1 |
| Gomes, KMS | 1 |
| Bechara, LRG | 1 |
| Voltarelli, VA | 1 |
| Bozi, LHM | 1 |
| Ribeiro, MAC | 1 |
| Ferreira, ND | 1 |
| Moreira, JBN | 1 |
| Brum, PC | 1 |
| Bodine, SC | 1 |
| Ferreira, JCB | 1 |
| Maeda, H | 1 |
| Nagai, H | 1 |
| Takemura, G | 1 |
| Shintani-Ishida, K | 1 |
| Komatsu, M | 1 |
| Ogura, S | 1 |
| Aki, T | 1 |
| Shirai, M | 1 |
| Kuwahira, I | 1 |
| Yoshida, K | 1 |
| Jing, F | 1 |
| Liu, M | 1 |
| Yang, N | 1 |
| Liu, Y | 1 |
| Li, X | 1 |
| Li, J | 1 |
| Zhang, T | 1 |
| Luo, XJ | 1 |
| Sai, WB | 2 |
| Yu, MF | 2 |
| Li, WE | 1 |
| Ma, YF | 1 |
| Chen, W | 2 |
| Zhai, K | 2 |
| Qin, G | 2 |
| Guo, D | 2 |
| Zheng, YM | 2 |
| Wang, YX | 2 |
| Shen, JH | 1 |
| Ji, G | 2 |
| Liu, QH | 2 |
| Wei, MY | 1 |
| Xue, L | 1 |
| Tan, L | 1 |
| Liu, XC | 1 |
| Jiang, QJ | 1 |
| Shen, J | 1 |
| Peng, YB | 1 |
| Zhao, P | 1 |
| Ma, LQ | 1 |
| Zou, C | 1 |
| Pulkkinen, V | 1 |
| Manson, ML | 1 |
| Säfholm, J | 1 |
| Adner, M | 1 |
| Dahlén, SE | 1 |
| Fontaine, J | 3 |
| Ouedraogo, CO | 1 |
| Famaey, JP | 2 |
| Reuse, J | 3 |
| Witiak, DT | 1 |
| Grattan, DA | 1 |
| Heaslip, RJ | 1 |
| Rahwan, RG | 1 |
| Ette, EI | 1 |
| Essien, EE | 1 |
| Marquis, VO | 1 |
| Ojewole, JA | 1 |
| Minker, E | 1 |
| Kádár, T | 1 |
| Matejka, Z | 1 |
| Horio, S | 1 |
| Nagare, T | 1 |
| Ishida, Y | 1 |
| Moritoki, H | 1 |
| Cao, J | 1 |
| Chen, M | 1 |
| Wang, Q | 1 |
| Nwaigwe, CI | 1 |
| Adegunloye, BJ | 1 |
| Sofola, OA | 1 |
| Famaey, J | 1 |
| Ayitey-Smith, E | 1 |
| Vartanian, GA | 3 |
| Akubue, PI | 1 |
| Kasperek, GJ | 1 |
| Conway, GR | 1 |
| Krayeski, DS | 1 |
| Lohne, JJ | 1 |
| Lot, TY | 1 |
| Okwuasaba, FK | 1 |
| Otubu, JA | 1 |
| Udoh, FV | 1 |
| Sackeyfio, AC | 1 |
| Amankwaah, DK | 1 |
| Yahaya, AS | 1 |
| Ebeigbe, AB | 1 |
| Aloamaka, CP | 1 |
| Alohan, FI | 1 |
| Zijlstra, FJ | 1 |
| Vincent, JE | 1 |
| Damerau, B | 1 |
| Roesler, J | 1 |
| Vogt, W | 1 |
| Welkov, S | 1 |
| Bajdekoff, B | 1 |
| Chinyanga, HM | 2 |
| Okai, EA | 1 |
| Greenberger, DV | 1 |
| Garcia, M | 1 |
| Miyares, C | 1 |
| Sainz, F | 1 |
| Castles, TR | 1 |
| Loth, E | 1 |
| Crawford, CR | 1 |
| Lee, CC | 1 |
| Aviado, DM | 1 |
| Bellet, S | 1 |
32 other studies available for chloroquine and Muscle Contraction
| Article | Year |
|---|---|
Alstiphyllanines A-D, indole alkaloids from Alstonia macrophylla.
Topics: Alstonia; Animals; Antimalarials; Aorta; Endothelium; Indole Alkaloids; Indonesia; Molecular Structu | 2009 |
Bitter taste receptors as targets for tocolytics in preterm labor therapy.
Topics: Albuterol; Animals; Calcium; Chloroquine; Female; Gene Expression Regulation; Humans; Magnesium Sulf | 2017 |
Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy.
Topics: Animals; Antirheumatic Agents; Autophagy; Chloroquine; Male; Mice, Knockout; Mice, Transgenic; Muscl | 2018 |
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.
Topics: Adenine; Animals; Autophagy; Chloroquine; Heart Diseases; Heart Failure; Hypoxia; Lysosomes; Male; M | 2013 |
Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa.
Topics: Animals; Calcium; Chloroquine; Enzyme Inhibitors; Gastrointestinal Motility; Ileum; Intestinal Mucos | 2013 |
Non-selective cation channels mediate chloroquine-induced relaxation in precontracted mouse airway smooth muscle.
Topics: Acetylcholine; Action Potentials; Animals; Antirheumatic Agents; Calcium; Calcium Channels, L-Type; | 2014 |
Involvement of large-conductance Ca2+-activated K+ channels in chloroquine-induced force alterations in pre-contracted airway smooth muscle.
Topics: Animals; Calcium Channel Blockers; Calcium Signaling; Chloroquine; In Vitro Techniques; Large-Conduc | 2015 |
The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.
Topics: Albuterol; Animals; Bronchodilator Agents; Carbachol; Charybdotoxin; Chloroquine; Cholinergic Agonis | 2012 |
An analysis of the inhibitory effects of quinine and mepacrine in the guinea-pig isolated ileum.
Topics: Animals; Chloroquine; Depression, Chemical; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contract | 1980 |
Synthesis and preliminary pharmacological evaluation of asymmetric chloroquine analogues.
Topics: Acetylcholine; Animals; Chloroquine; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Sm | 1981 |
Actions of chloroquine and its N-oxidation metabolites on the rectus abdominis muscle of the toad (Bufo regularis).
Topics: Acetylcholine; Animals; Biotransformation; Bufonidae; Carbachol; Chloroquine; Cyclic N-Oxides; In Vi | 1981 |
Effect of chloroquine and mepacrine on the spontaneous and evoked movements of the rat portal vein.
Topics: Animals; Chloroquine; Dose-Response Relationship, Drug; Epinephrine; Female; In Vitro Techniques; Ma | 1980 |
Interaction of local anaesthetics with histamine H1 receptors in guinea-pig ileum.
Topics: Anesthetics, Local; Animals; Binding, Competitive; Chloroquine; Dose-Response Relationship, Drug; Fe | 1997 |
[Mechanism of vascular desensitization to agonists].
Topics: Angiotensin II; Animals; Arsenicals; Chloroquine; Male; Muscle Contraction; Muscle, Smooth, Vascular | 1996 |
Effect of chloroquine on the contractility of the smooth muscles of the rat uterus, trachea and urinary bladder.
Topics: Animals; Chloroquine; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rats; Rats, S | 1997 |
An analysis of the inhibitory effects and of possible prostaglandins antagonism of chloroquine in the guinea-pig isolated ileum.
Topics: Acetylcholine; Animals; Chloroquine; Guinea Pigs; Histamine Antagonists; Ileum; In Vitro Techniques; | 1977 |
Dual action of chloroquine on frog's skeletal muscle contraction.
Topics: Acetylcholine; Animals; Caffeine; Carbachol; Chloroquine; Cholinesterase Inhibitors; Cholinesterases | 1975 |
Inhibiting effects of morphine, chloroquine, nonsteroidal and steroidal anti-inflammatory drugs on electrically-induced contractions of guinea-pig ileum and the reversing effect of prostaglandins.
Topics: Animals; Anti-Inflammatory Agents; Chloroquine; Drug Interactions; Electric Stimulation; Guinea Pigs | 1975 |
The action of chloroquine on the histamine receptors of the isolated guinea-pig ileum.
Topics: Acetylcholine; Animals; Chloroquine; Electric Stimulation; Guinea Pigs; Hypogastric Plexus; Ileum; I | 1975 |
A reexamination of the effect of exercise on rate of muscle protein degradation.
Topics: Animals; Chloroquine; Electric Stimulation; Lysosomes; Male; Methylhistidines; Motor Activity; Muscl | 1992 |
Smooth muscle sensitization and neuromuscular depression induced by chronic administration of antimalarial drugs.
Topics: Acetylcholine; Animals; Chickens; Chloroquine; Culture Techniques; Dose-Response Relationship, Drug; | 1992 |
Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro.
Topics: Animals; Caffeine; Calcium; Chloroquine; Dantrolene; Diaphragm; Electric Stimulation; Female; In Vit | 1990 |
Interaction between chloroquine and indomethacin in airways smooth muscle in vivo.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bronchi; Chloroquine; Female; Guinea Pigs; Histamine; | 1987 |
Mechanism of chloroquine-induced inhibition of smooth muscle contraction.
Topics: Acetylcholine; Animals; Calcium; Chloroquine; In Vitro Techniques; Isometric Contraction; Male; Musc | 1986 |
Leukotriene D4 and phospholipase A2 release thromboxane A2 of different origin in the guinea pig lung parenchymal strip.
Topics: Animals; Chloroquine; Guinea Pigs; Indomethacin; Lung; Muscle Contraction; Phospholipases; Phospholi | 1985 |
Pharmacological characterization of the slow component of deactivation of guinea-pig isolated ileum to the spasmogenic action of C5adesArg.
Topics: Animals; Chloroquine; Colchicine; Complement C5; Complement C5a, des-Arginine; Cycloheximide; Cytoch | 1985 |
[Artroquine action on the serotonin effect in vitro and in vivo].
Topics: Animals; Capillary Permeability; Chloroquine; Drug Synergism; Female; Male; Muscle Contraction; Musc | 1972 |
Chloroquine-induced depression of neuromuscular transmission.
Topics: Action Potentials; Animals; Anura; Axons; Chloroquine; Depression, Chemical; Electric Stimulation; E | 1972 |
The mechanism of acute neuromuscular weakness induced by chloroquine.
Topics: Action Potentials; Animals; Anura; Axons; Chloroquine; Electric Stimulation; In Vitro Techniques; Me | 1972 |
An eserine-like action of chloroquine.
Topics: Acetylcholine; Animals; Chloroquine; Cholinesterase Inhibitors; Duodenum; Guinea Pigs; Ileum; Kymogr | 1971 |
The neuromuscular blocking properties of the antimalarial agent, bis((chloro-7"-quinolyl-4")amino-2'-propyl)-1,4-piperazine.
Topics: Acetylcholine; Animals; Antimalarials; Apnea; Calcium; Chloroquine; Diaphragm; Electric Stimulation; | 1970 |
Comparative toxicity of chloroquine and bis[(chloro-7"-quinolyl-4")-amino-2'propyl]-1,4-piperazine (WR 3863).
Topics: Animals; Animals, Newborn; Antimalarials; Aorta; Blood Pressure; Cardiac Output; Cats; Chloroquine; | 1969 |