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chloroquine and Multiple Sclerosis

chloroquine has been researched along with Multiple Sclerosis in 8 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thome, R4
Bonfanti, AP2
Rasouli, J1
Mari, ER1
Zhang, GX1
Rostami, A1
Verinaud, L4
Moraes, AS1
Bombeiro, AL2
Farias, Ados S1
Francelin, C1
da Costa, TA3
Di Gangi, R3
dos Santos, LM1
de Oliveira, AL2
Issayama, LK2
Zanucoli, F1
de Carvalho, AC1
Ferreira, IT2
Machado, DR1
Rapôso, C1
Lopes, SC1
Longhini, AL1
Oliveira, AL1
da Cruz Höfling, MA1
Costa, FT1
MILLER, HG1
FOSTER, JB1
NEWELL, DJ1
BARWICK, DD1
BREWIS, RA1
SULLI, G1
VARRONE, F1
LOUYOT, P1
GAUCHER, A1
JEANBLANC, J1
MONTET, Y1
Miller, H1

Reviews

2 reviews available for chloroquine and Multiple Sclerosis

ArticleYear
[EXTRAMALARIAL THERAPUETIC APPLICATIONS OF ANTIMALARIAL DRUGS. 1. CLINICAL UTILIZATIONS].
    La Clinica terapeutica, 1963, Oct-31, Volume: 27

    Topics: Amodiaquine; Antimalarials; Chloroquine; Collagen Diseases; Dermatology; Drug Utilization; Epilepsy;

1963
The clinical contribution to multiple sclerosis research.
    Transactions of the American Neurological Association, 1969, Volume: 94

    Topics: Chloroquine; Climate; Diet; Female; Humans; Male; Multiple Sclerosis; Pakistan; Poland; Research; Se

1969

Other Studies

6 other studies available for chloroquine and Multiple Sclerosis

ArticleYear
Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity.
    European journal of immunology, 2018, Volume: 48, Issue:7

    Topics: Animals; Autoantigens; Cells, Cultured; Chloroquine; Dendritic Cells; Disease Models, Animal; Enceph

2018
Chloroquine treatment enhances regulatory T cells and reduces the severity of experimental autoimmune encephalomyelitis.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Adoptive Transfer; Animals; Anti-Inflammatory Agents; Cells, Cultured; Central Nervous System; Chlor

2013
Nitric oxide plays a key role in the suppressive activity of tolerogenic dendritic cells.
    Cellular & molecular immunology, 2015, Volume: 12, Issue:3

    Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Dendritic Cells; Encephalomyelitis, Autoimmune

2015
Exacerbation of autoimmune neuro-inflammation in mice cured from blood-stage Plasmodium berghei infection.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chloroquine; Encephalomyelitis, Aut

2014
MULTIPLE SCLEROSIS: THERAPEUTIC TRIALS OF CHLOROQUINE, SOLUBLE ASPIRIN, AND GAMMAGLOBULIN.
    British medical journal, 1963, Dec-07, Volume: 2, Issue:5370

    Topics: Aspirin; Chloroquine; gamma-Globulins; Humans; Multiple Sclerosis

1963
[EVALUATION OF LONG-TERM THERAPY WITH CHLOROQUINE AND HYDROXYCHLOROQUINE IN RHEUMATOLOGY].
    Rhumatologie, 1964, Volume: 16

    Topics: Arthritis; Arthritis, Rheumatoid; Chloroquine; Drug Therapy; Humans; Hydrarthrosis; Hydroxychloroqui

1964