chloroquine has been researched along with Multiple Sclerosis in 8 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (50.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 4 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Thome, R | 4 |
Bonfanti, AP | 2 |
Rasouli, J | 1 |
Mari, ER | 1 |
Zhang, GX | 1 |
Rostami, A | 1 |
Verinaud, L | 4 |
Moraes, AS | 1 |
Bombeiro, AL | 2 |
Farias, Ados S | 1 |
Francelin, C | 1 |
da Costa, TA | 3 |
Di Gangi, R | 3 |
dos Santos, LM | 1 |
de Oliveira, AL | 2 |
Issayama, LK | 2 |
Zanucoli, F | 1 |
de Carvalho, AC | 1 |
Ferreira, IT | 2 |
Machado, DR | 1 |
Rapôso, C | 1 |
Lopes, SC | 1 |
Longhini, AL | 1 |
Oliveira, AL | 1 |
da Cruz Höfling, MA | 1 |
Costa, FT | 1 |
MILLER, HG | 1 |
FOSTER, JB | 1 |
NEWELL, DJ | 1 |
BARWICK, DD | 1 |
BREWIS, RA | 1 |
SULLI, G | 1 |
VARRONE, F | 1 |
LOUYOT, P | 1 |
GAUCHER, A | 1 |
JEANBLANC, J | 1 |
MONTET, Y | 1 |
Miller, H | 1 |
2 reviews available for chloroquine and Multiple Sclerosis
Article | Year |
---|---|
[EXTRAMALARIAL THERAPUETIC APPLICATIONS OF ANTIMALARIAL DRUGS. 1. CLINICAL UTILIZATIONS].
Topics: Amodiaquine; Antimalarials; Chloroquine; Collagen Diseases; Dermatology; Drug Utilization; Epilepsy; | 1963 |
The clinical contribution to multiple sclerosis research.
Topics: Chloroquine; Climate; Diet; Female; Humans; Male; Multiple Sclerosis; Pakistan; Poland; Research; Se | 1969 |
6 other studies available for chloroquine and Multiple Sclerosis
Article | Year |
---|---|
Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity.
Topics: Animals; Autoantigens; Cells, Cultured; Chloroquine; Dendritic Cells; Disease Models, Animal; Enceph | 2018 |
Chloroquine treatment enhances regulatory T cells and reduces the severity of experimental autoimmune encephalomyelitis.
Topics: Adoptive Transfer; Animals; Anti-Inflammatory Agents; Cells, Cultured; Central Nervous System; Chlor | 2013 |
Nitric oxide plays a key role in the suppressive activity of tolerogenic dendritic cells.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Dendritic Cells; Encephalomyelitis, Autoimmune | 2015 |
Exacerbation of autoimmune neuro-inflammation in mice cured from blood-stage Plasmodium berghei infection.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chloroquine; Encephalomyelitis, Aut | 2014 |
MULTIPLE SCLEROSIS: THERAPEUTIC TRIALS OF CHLOROQUINE, SOLUBLE ASPIRIN, AND GAMMAGLOBULIN.
Topics: Aspirin; Chloroquine; gamma-Globulins; Humans; Multiple Sclerosis | 1963 |
[EVALUATION OF LONG-TERM THERAPY WITH CHLOROQUINE AND HYDROXYCHLOROQUINE IN RHEUMATOLOGY].
Topics: Arthritis; Arthritis, Rheumatoid; Chloroquine; Drug Therapy; Humans; Hydrarthrosis; Hydroxychloroqui | 1964 |