chloroquine has been researched along with Multiple Myeloma in 16 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cotreatment with chloroquine, which blocks autophagy, strongly potentiated apoptosis in vitro and in vivo." | 1.43 | Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo. ( Anel, A; de Miguel, D; Gonzalo, O; Jaime, P; Jarauta, V; Martínez-Lostao, L; Marzo, I; Naval, J; Pardo, J; Ramírez-Labrada, A, 2016) |
| "Treatment with melphalan plus the proteasome inhibitor MG132 reduced global protein degradation for MM cells to roughly 60% of that seen without drugs, but the reduction was approximately three times greater for CCL-156 cells." | 1.38 | Evidence that aberrant protein metabolism contributes to chemoresistance in multiple myeloma cells. ( Burgis, NE; Lewis, BS; Sipes, RK; Xia, X, 2012) |
| "A case of systemic lupus erythematosus (SLE) complicated by multiple myeloma is presented." | 1.32 | Multiple myeloma associated with systemic lupus erythematosus. ( Kaklamanis, P; Konstantopoulos, K; Mantzourani, M; Vaiopoulos, G, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 8 |
| Seupel, R | 1 |
| Feineis, D | 1 |
| Mudogo, V | 1 |
| Kaiser, M | 1 |
| Brun, R | 1 |
| Brünnert, D | 1 |
| Chatterjee, M | 1 |
| Seo, EJ | 1 |
| Efferth, T | 1 |
| Bringmann, G | 1 |
| Li, A | 1 |
| Li, X | 11 |
| Chen, X | 2 |
| Zeng, C | 3 |
| Wang, Z | 2 |
| Li, Z | 3 |
| Chen, J | 2 |
| Zhang, L | 3 |
| Rastgoo, N | 1 |
| Wu, J | 3 |
| Zhang, M | 5 |
| Pourabdollah, M | 1 |
| Zacksenhaus, E | 1 |
| Chen, Y | 4 |
| Chang, H | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
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| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
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| Tsybin, YO | 1 |
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| Zin, NNINM | 1 |
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| Xing, YL | 1 |
| Chen, MA | 1 |
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| Neradilek, MB | 1 |
| Wu, XT | 1 |
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| Huang, W | 1 |
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| Yang, QQ | 1 |
| Li, HW | 1 |
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| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
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| Dong, XR | 1 |
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| Chen, L | 3 |
| Shan, A | 1 |
| Zhao, H | 2 |
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| Li, Y | 5 |
| Xue, F | 1 |
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| Anastassiadou, M | 1 |
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| Wang, C | 3 |
| Zhou, X | 2 |
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| Wang, S | 2 |
| Hou, J | 1 |
| Zhang, A | 1 |
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| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 1 |
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| Zhuang, T | 1 |
| Tu, J | 1 |
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| Yao, H | 1 |
| Wang, X | 5 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
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| Zhang, Y | 5 |
| Wu, X | 1 |
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| Wu, W | 1 |
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| Xu, Z | 1 |
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1 review available for chloroquine and Multiple Myeloma
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
1 trial available for chloroquine and Multiple Myeloma
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
15 other studies available for chloroquine and Multiple Myeloma
| Article | Year |
|---|---|
Dioncophyllines C
Topics: Alkaloids; Antimalarials; Antineoplastic Agents; Humans; Isoquinolines; Magnoliopsida; Molecular Str | 2017 |
NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway.
Topics: Adenine; Apoptosis; Autophagy; Basic Helix-Loop-Helix Transcription Factors; Bone Marrow Cells; Cell | 2020 |
MARCKS inhibition cooperates with autophagy antagonists to potentiate the effect of standard therapy against drug-resistant multiple myeloma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Bortezomib; Cell Line, Tumor; Ch | 2020 |
Inhibition of autophagy enhances the antitumour activity of tigecycline in multiple myeloma.
Topics: Adenylate Kinase; Animals; Antineoplastic Agents; Autophagosomes; Autophagy; Cell Cycle Checkpoints; | 2018 |
KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models.
Topics: Adaptor Proteins, Signal Transducing; Autophagy; Cell Line, Tumor; Cell Survival; Chloroquine; Drug | 2015 |
Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; A | 2016 |
Effect of autophagy on multiple myeloma cell viability.
Topics: Adenine; Antifungal Agents; Antimalarials; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Pr | 2009 |
Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine.
Topics: Adenosine; Adenosine Triphosphate; Autophagy; Cell Line, Tumor; Cell Membrane; Cell Proliferation; C | 2009 |
Evidence that aberrant protein metabolism contributes to chemoresistance in multiple myeloma cells.
Topics: Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Resist | 2012 |
Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cells | 2012 |
Multiple myeloma associated with systemic lupus erythematosus.
Topics: Aged; Chloroquine; Female; Humans; Lupus Erythematosus, Systemic; Melphalan; Multiple Myeloma; Parap | 2003 |
Idiotype-induced T cell stimulation requires antigen presentation in association with HLA-DR molecules.
Topics: Antigen Presentation; Antigen-Presenting Cells; Chloroquine; HLA-DR Antigens; Humans; Immunoglobulin | 1996 |
In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides.
Topics: Alkaloids; Antimalarials; Benzylisoquinolines; Chloroquine; Erythrocytes; Fibroblasts; Humans; Isoqu | 1997 |
Dendritic cells derived from multiple myeloma patients efficiently internalize different classes of myeloma protein.
Topics: Antigen Presentation; Antigens, Neoplasm; Cancer Vaccines; Cell Differentiation; Cells, Cultured; Ch | 2001 |
Phagocytosis by human monocytes.
Topics: Antimetabolites; Blood Group Antigens; Candida; Carbon Isotopes; Chloroquine; Cryptococcus; Erythroc | 1968 |