chloroquine has been researched along with Mucopolysaccharidoses in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Mucopolysaccharidoses: Group of lysosomal storage diseases each caused by an inherited deficiency of an enzyme involved in the degradation of glycosaminoglycans (mucopolysaccharides). The diseases are progressive and often display a wide spectrum of clinical severity within one enzyme deficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response curves were established for (a) the intracellular accumulation of 35S-GAGs and (b) the release of beta-hexosaminidase after exposure (72 hr) to tilorone (1-35 microM)." | 1.29 | Tilorone-induced lysosomal storage of sulphated glycosaminoglycans can be separated from tilorone-induced enhancement of lysosomal enzyme secretion. ( Lüllmann-Rauch, R; Pods, R; Von Witzendorff, B, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garvin, AJ | 1 |
| Lyubsky, S | 1 |
| Poore, CM | 1 |
| Lüllmann-Rauch, R | 2 |
| Pods, R | 2 |
| Von Witzendorff, B | 2 |
| Szabó, E | 1 |
| Dobozy, A | 1 |
| Kovács, L | 1 |
| Husz, S | 1 |
| Klinghardt, GW | 1 |
| Lie, SO | 1 |
6 other studies available for chloroquine and Mucopolysaccharidoses
| Article | Year |
|---|---|
A cytochemical study of GERL in cultured human fibroblasts.
Topics: Acid Phosphatase; Ammonium Chloride; Cells, Cultured; Centrioles; Chloroquine; Fibroblasts; Golgi Ap | 1981 |
Tilorone-induced lysosomal storage of sulphated glycosaminoglycans can be separated from tilorone-induced enhancement of lysosomal enzyme secretion.
Topics: Ammonium Chloride; Animals; beta-N-Acetylhexosaminidases; Cattle; Cells, Cultured; Chloroquine; Dose | 1995 |
The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; beta-N-Acetylhexosaminidases; Cattle; Cells, Cultu | 1996 |
[The REM syndrome].
Topics: Adult; Antibodies, Anti-Idiotypic; Autoantibodies; Chloroquine; Female; Fluorescent Antibody Techniq | 1979 |
[Experimental lesions of the nervous and muscular systems due to chloroquine: models of various storage dystrophies (author's transl)].
Topics: Animals; Chloroquine; Chromatography, Thin Layer; Disease Models, Animal; Germ-Free Life; Glycogen S | 1974 |
Induction of "storage disease" in normal human fibroblasts.
Topics: Cells, Cultured; Chloroquine; Fibroblasts; Glycosaminoglycans; Humans; Hydrogen-Ion Concentration; L | 1974 |