chloroquine has been researched along with Motor Neuron Disease in 1 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human cerebral malaria causes neurological and behavioral deficits which persist long after resolution of infection and clearance of parasites with antimalarial drugs." | 1.36 | Persistent cognitive and motor deficits after successful antimalarial treatment in murine cerebral malaria. ( Dai, M; Desruisseaux, MS; Gulinello, M; Reznik, SE; Spray, DC; Tanowitz, HB; Weiss, LM, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, M | 1 |
| Reznik, SE | 1 |
| Spray, DC | 1 |
| Weiss, LM | 1 |
| Tanowitz, HB | 1 |
| Gulinello, M | 1 |
| Desruisseaux, MS | 1 |
1 other study available for chloroquine and Motor Neuron Disease
| Article | Year |
|---|---|
Persistent cognitive and motor deficits after successful antimalarial treatment in murine cerebral malaria.
Topics: Animals; Antimalarials; Chloroquine; Cognition Disorders; Disease Models, Animal; Female; Malaria, C | 2010 |