chloroquine has been researched along with Methemoglobinemia in 10 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 25 year old man was rushed to the emergency department when he was found unconscious in his room after taking two chloroquine tablets (600 mg base) for fever prescribed by local practitioner." | 3.78 | Acute life-threatening methaemoglobinaemia following ingestion of chloroquine. ( Abdali, N; Asif, MS; Rizvi, I; Zaidi, N; Zaman, S, 2012) |
| "Methemoglobin, a toxic ferric form of hemoglobin, is continuously formed in normal erythrocytes, but during abnormal situations in situ, the level is enhanced." | 1.31 | A simple and rapid evaluation of methemoglobin toxicity of 8-aminoquinolines and related compounds. ( Jain, GK; Pandey, VC; Puri, SK; Singh, S; Srivastava, P, 2000) |
| "Primaquine was not detectable in the plasma of any of the volunteers, 24 h after each daily dose." | 1.26 | Studies on the pharmacokinetics of primaquine. ( Bunnag, D; Evans, DA; Fletcher, KA; Gilles, HM; Greaves, J; Harinasuta, T, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuipers, MT | 1 |
| van Zwieten, R | 1 |
| Heijmans, J | 1 |
| Rutten, CE | 1 |
| de Heer, K | 1 |
| Kater, AP | 1 |
| Nur, E | 1 |
| Vieira, JL | 1 |
| Ferreira, MES | 1 |
| Ferreira, MVD | 1 |
| Gomes, MM | 1 |
| Rizvi, I | 1 |
| Zaman, S | 1 |
| Zaidi, N | 1 |
| Asif, MS | 1 |
| Abdali, N | 1 |
| WITTMER, JF | 1 |
| Fletcher, KA | 1 |
| Evans, DA | 1 |
| Gilles, HM | 1 |
| Greaves, J | 1 |
| Bunnag, D | 1 |
| Harinasuta, T | 1 |
| Jaremin, B | 1 |
| Felczak-Korzybska, I | 1 |
| Myjak, P | 1 |
| Srivastava, P | 1 |
| Singh, S | 1 |
| Jain, GK | 1 |
| Puri, SK | 1 |
| Pandey, VC | 1 |
| Clyde, DF | 1 |
| Rebert, CC | 1 |
| McCarthy, VC | 1 |
| Dawkins, AT | 1 |
| Cucinell, SA | 1 |
| Cohen, RJ | 1 |
| Sachs, JR | 1 |
| Wicker, DJ | 1 |
| Conrad, ME | 1 |
| Sietsma, A | 1 |
| Naughton, MA | 1 |
| Harley, JD | 1 |
1 trial available for chloroquine and Methemoglobinemia
| Article | Year |
|---|---|
Diformyl diaminodiphenyl sufone (DFD) as an antimalarial in man.
Topics: Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Dapsone; Formates; Humans; Malaria; Mal | 1970 |
9 other studies available for chloroquine and Methemoglobinemia
| Article | Year |
|---|---|
Glucose-6-phosphate dehydrogenase deficiency-associated hemolysis and methemoglobinemia in a COVID-19 patient treated with chloroquine.
Topics: Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Glucosephos | 2020 |
Primaquine in Plasma and Methemoglobinemia in Patients with Malaria Due to
Topics: Adolescent; Adult; Antimalarials; Brazil; Chloroquine; Drug Administration Schedule; Drug Therapy, C | 2017 |
Acute life-threatening methaemoglobinaemia following ingestion of chloroquine.
Topics: Acute Disease; Adult; Antimalarials; Chloroquine; Diagnosis, Differential; Enzyme Inhibitors; Fever; | 2012 |
AEROMEDICAL ASPECTS OF MALARIA PROPHYLAXIS WITH CHLOROQUINE-PRIMAQUINE.
Topics: Aerospace Medicine; Anemia; Anemia, Hemolytic; Chloroquine; Humans; Malaria; Methemoglobinemia; Moto | 1963 |
Studies on the pharmacokinetics of primaquine.
Topics: Chloroquine; Half-Life; Humans; Male; Methemoglobinemia; Primaquine | 1981 |
[A case of methemoglobinemia and agranulocytosis during the treatment of malaria (pl. ovale) with arequine and primaquine].
Topics: Adult; Agranulocytosis; Antimalarials; Chloroquine; Humans; Malaria; Male; Methemoglobinemia; Primaq | 1982 |
A simple and rapid evaluation of methemoglobin toxicity of 8-aminoquinolines and related compounds.
Topics: Administration, Cutaneous; Administration, Oral; Aminoquinolines; Animals; Antimalarials; Artemisini | 2000 |
Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam.
Topics: Antimalarials; Chloroquine; Cyanosis; Dapsone; Diseases in Twins; Erythrocytes; Female; Hematocrit; | 1968 |
"Blue soldiers".
Topics: Australia; Chloroquine; Cyanosis; Humans; Male; Methemoglobinemia; Military Medicine; Primaquine | 1968 |