chloroquine has been researched along with Metastase in 33 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "MiaPaCa2 (non-metastatic) and S2VP10 (metastatic) cell lines were treated with 25 and 50 µM chloroquine for 24 and 48 hours in normoxia and hypoxia (5-10% O₂)." | 7.80 | Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. ( Frieboes, HB; Huang, JS; McNally, LR; Yin, WC, 2014) |
| "Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment." | 5.43 | Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model. ( Bérubé-Lauzière, Y; Bouchard, G; Bujold, R; Geha, S; Paquette, B; Saucier, C; Therriault, H, 2016) |
| "Metastatic breast cancers are hard to treat and almost always fatal." | 5.36 | Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. ( Deng, XQ; Jiang, PD; Li, ZG; Mao, YQ; Shi, W; Tang, QQ; Wei, YQ; Yang, SY; Zhao, YL; Zheng, YZ, 2010) |
| "MiaPaCa2 (non-metastatic) and S2VP10 (metastatic) cell lines were treated with 25 and 50 µM chloroquine for 24 and 48 hours in normoxia and hypoxia (5-10% O₂)." | 3.80 | Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. ( Frieboes, HB; Huang, JS; McNally, LR; Yin, WC, 2014) |
| " Combined chloroquine and HDACi treatment abrogates growth of human MPNST xenografts and lung metastases." | 3.77 | Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: potential implications for the treatment of a therapeutic-resistant malignancy. ( Lev, D; Lopez, G; Torres, K, 2011) |
| " Chloroquine, ergotamine, ethaverine and chronic abuse of non-narcotic analgesic drugs seem to be responsible for the drug-induced cutaneous neuro-phospholipidosis, whereas the same condition was found in two patients with metastatic bronchogenic carcinoma and malignant melanoma." | 3.65 | Tumor- and drug-induced cutaneous neuro-phospholipidosis. ( Orfanos, CE; Runne, U, 1975) |
| "CAFs contribute to metastasis process through direct or indirect interaction with tumor cells; however, the underlying mechanism is largely unknown." | 1.62 | Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling. ( Cao, L; Chen, M; Furlong, F; Guo, X; Li, X; Meng, Z; Ren, Y; Wang, L; Wu, X; Xu, K; Zhang, Q; Zheng, S, 2021) |
| "Metastatic prostate cancer cell lines (PC-3 and LNCaP) were treated with Pd (II) complex, CQ, and their combination." | 1.56 | A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex. ( Akar, RO; Ari, F; Aydinlik, S; Aztopal, N; Celikler, S; Cevatemre, B; Erkisa, M; Ulukaya, E; Yilmaz, VT, 2020) |
| "Overexpression of PBK decreased ovarian cancer responsiveness to cisplatin treatment through inducing autophagy in vivo." | 1.51 | PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma. ( Gao, M; Kong, B; Li, R; Li, Y; Ma, H; Qi, G; Wang, X; Wu, H; Yan, S; Yang, N; Yuan, C, 2019) |
| " For potential clinical application, DC vaccine preparations treated with tumor cells that were already pretreated with chloroquine and shikonin further enhanced the antimetastatic activity of 4T1 tumors and reduced the effective dosage of doxorubicin." | 1.48 | Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance. ( Fan, YT; Hsiao, PW; Hsieh, SY; Lin, SY; Tsai, DH; Wei, WC; Wu, TS; Yang, NS, 2018) |
| "Trehalose-treated mice had significantly more BMDCs than either vehicle- or CQ-treated mice." | 1.43 | Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease. ( Barnard, RA; Gustafson, DL; Hansen, RJ; Maycotte, P; Regan, DP; Thorburn, A, 2016) |
| "Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment." | 1.43 | Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model. ( Bérubé-Lauzière, Y; Bouchard, G; Bujold, R; Geha, S; Paquette, B; Saucier, C; Therriault, H, 2016) |
| "Invasion of hepatocellular carcinoma (HCC) cells is a leading cause of intrahepatic dissemination and metastasis." | 1.39 | Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition. ( Guo, Y; Li, J; Shang, D; Song, Z; Wu, Y; Xiong, J; Yang, B; Zheng, Q; Zhou, Q, 2013) |
| "Metastatic breast cancers are hard to treat and almost always fatal." | 1.36 | Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. ( Deng, XQ; Jiang, PD; Li, ZG; Mao, YQ; Shi, W; Tang, QQ; Wei, YQ; Yang, SY; Zhao, YL; Zheng, YZ, 2010) |
| "Chloroquine treatment of intact cells leads to a 4-fold and a 3-fold increase in galactosylation of the Mr = 110,000 protein and glucosylceramide, respectively, suggesting that these two substrates normally reside mostly in the lysosomal or Golgi compartments." | 1.28 | Metastasis-associated murine melanoma cell surface galactosyltransferase: characterization of enzyme activity and identification of the major surface substrates. ( Hart, GW; Passaniti, A, 1990) |
| "In a patient with acute myelogenous leukemia infected with Plasmodium vivax, neither his underlying disease nor intensive cytotoxic chemotherapy appeared to ameliorate or worsen the clinical course of his infection." | 1.26 | Malaria complicating neoplastic disease. ( Armstrong, D; Tapper, ML, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (36.36) | 18.7374 |
| 1990's | 1 (3.03) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 16 (48.48) | 24.3611 |
| 2020's | 4 (12.12) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, Y | 1 |
| Cao, L | 1 |
| Wang, L | 1 |
| Zheng, S | 1 |
| Zhang, Q | 1 |
| Guo, X | 1 |
| Li, X | 1 |
| Chen, M | 1 |
| Wu, X | 2 |
| Furlong, F | 1 |
| Meng, Z | 1 |
| Xu, K | 1 |
| Erkisa, M | 1 |
| Aydinlik, S | 1 |
| Cevatemre, B | 1 |
| Aztopal, N | 1 |
| Akar, RO | 1 |
| Celikler, S | 1 |
| Yilmaz, VT | 1 |
| Ari, F | 1 |
| Ulukaya, E | 1 |
| Zhang, D | 1 |
| Reyes, RM | 1 |
| Osta, E | 1 |
| Kari, S | 1 |
| Gupta, HB | 1 |
| Padron, AS | 1 |
| Kornepati, AVR | 1 |
| Kancharla, A | 1 |
| Sun, X | 1 |
| Deng, Y | 1 |
| Wu, B | 1 |
| Vadlamudi, R | 1 |
| Li, R | 2 |
| Svatek, RS | 1 |
| Curiel, TJ | 1 |
| Chen, C | 1 |
| Zhang, H | 1 |
| Yu, Y | 1 |
| Huang, Q | 1 |
| Wang, W | 1 |
| Niu, J | 1 |
| Lou, J | 1 |
| Ren, T | 1 |
| Huang, Y | 1 |
| Guo, W | 1 |
| Lin, SY | 1 |
| Hsieh, SY | 1 |
| Fan, YT | 1 |
| Wei, WC | 1 |
| Hsiao, PW | 1 |
| Tsai, DH | 1 |
| Wu, TS | 1 |
| Yang, NS | 1 |
| Morgan, MJ | 1 |
| Fitzwalter, BE | 1 |
| Owens, CR | 1 |
| Powers, RK | 1 |
| Sottnik, JL | 1 |
| Gamez, G | 1 |
| Costello, JC | 1 |
| Theodorescu, D | 1 |
| Thorburn, A | 2 |
| Ma, H | 1 |
| Li, Y | 1 |
| Wang, X | 1 |
| Wu, H | 1 |
| Qi, G | 1 |
| Yang, N | 1 |
| Gao, M | 1 |
| Yan, S | 1 |
| Yuan, C | 1 |
| Kong, B | 1 |
| Yan, Z | 1 |
| Ohuchida, K | 1 |
| Fei, S | 1 |
| Zheng, B | 1 |
| Guan, W | 1 |
| Feng, H | 1 |
| Kibe, S | 1 |
| Ando, Y | 1 |
| Koikawa, K | 1 |
| Abe, T | 1 |
| Iwamoto, C | 1 |
| Shindo, K | 1 |
| Moriyama, T | 1 |
| Nakata, K | 1 |
| Miyasaka, Y | 1 |
| Ohtsuka, T | 1 |
| Mizumoto, K | 1 |
| Hashizume, M | 1 |
| Nakamura, M | 1 |
| Li, J | 1 |
| Yang, B | 1 |
| Zhou, Q | 1 |
| Wu, Y | 1 |
| Shang, D | 1 |
| Guo, Y | 1 |
| Song, Z | 1 |
| Zheng, Q | 1 |
| Xiong, J | 1 |
| Frieboes, HB | 1 |
| Huang, JS | 1 |
| Yin, WC | 1 |
| McNally, LR | 1 |
| Maes, H | 1 |
| Kuchnio, A | 1 |
| Carmeliet, P | 1 |
| Agostinis, P | 1 |
| Thongchot, S | 1 |
| Loilome, W | 1 |
| Yongvanit, P | 1 |
| Dokduang, H | 1 |
| Thanan, R | 1 |
| Techasen, A | 1 |
| Namwat, N | 1 |
| Margalef, P | 1 |
| Colomer, C | 1 |
| Villanueva, A | 1 |
| Montagut, C | 1 |
| Iglesias, M | 1 |
| Bellosillo, B | 1 |
| Salazar, R | 1 |
| Martínez-Iniesta, M | 1 |
| Bigas, A | 1 |
| Espinosa, L | 1 |
| Liang, DH | 1 |
| Choi, DS | 1 |
| Ensor, JE | 1 |
| Kaipparettu, BA | 1 |
| Bass, BL | 1 |
| Chang, JC | 1 |
| Barnard, RA | 1 |
| Regan, DP | 1 |
| Hansen, RJ | 1 |
| Maycotte, P | 1 |
| Gustafson, DL | 1 |
| Bouchard, G | 1 |
| Therriault, H | 1 |
| Geha, S | 1 |
| Bérubé-Lauzière, Y | 1 |
| Bujold, R | 1 |
| Saucier, C | 1 |
| Paquette, B | 1 |
| Burikhanov, R | 1 |
| Hebbar, N | 1 |
| Noothi, SK | 1 |
| Shukla, N | 1 |
| Sledziona, J | 1 |
| Araujo, N | 1 |
| Kudrimoti, M | 1 |
| Wang, QJ | 1 |
| Watt, DS | 1 |
| Welch, DR | 1 |
| Maranchie, J | 1 |
| Harada, A | 1 |
| Rangnekar, VM | 1 |
| Chi, C | 1 |
| Zhu, H | 1 |
| Han, M | 1 |
| Zhuang, Y | 1 |
| Xu, T | 1 |
| Jiang, PD | 1 |
| Zhao, YL | 1 |
| Deng, XQ | 1 |
| Mao, YQ | 1 |
| Shi, W | 1 |
| Tang, QQ | 1 |
| Li, ZG | 1 |
| Zheng, YZ | 1 |
| Yang, SY | 1 |
| Wei, YQ | 1 |
| Lopez, G | 1 |
| Torres, K | 1 |
| Lev, D | 1 |
| Giraldi, T | 1 |
| Sava, G | 1 |
| Kopitar, M | 1 |
| Brzin, J | 1 |
| Turk, V | 1 |
| Orfanos, CE | 1 |
| Runne, U | 1 |
| Tapper, ML | 1 |
| Armstrong, D | 1 |
| Passaniti, A | 1 |
| Hart, GW | 1 |
| Blanquet, P | 5 |
| Vérin, PH | 1 |
| Safi, N | 5 |
| Tanneberger, S | 1 |
| Bacigalupo, G | 1 |
| Vérin, P | 2 |
| Schaub, KJ | 1 |
| Boyd, CM | 1 |
| Lieberman, LM | 1 |
| Beierwaltes, WH | 1 |
| Varma, VM | 1 |
| Johnston, GS | 1 |
| Jones, AE | 1 |
| Le Coulant, P | 1 |
| Texier, L | 1 |
| Tamisier, JM | 1 |
| Moretti, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Study of Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer[NCT04011410] | Phase 2 | 20 participants (Actual) | Interventional | 2019-12-03 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for chloroquine and Metastase
| Article | Year |
|---|---|
Diagnostic efficacy of a radioiodinated chloroquine analog in patients with malignant melanoma.
Topics: Brain Neoplasms; Chloroquine; Clinical Trials as Topic; Eye Neoplasms; Humans; Iodine Radioisotopes; | 1970 |
32 other studies available for chloroquine and Metastase
| Article | Year |
|---|---|
Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling.
Topics: Adenine; Autophagy; Autophagy-Related Protein 5; Cancer-Associated Fibroblasts; Carcinoma, Non-Small | 2021 |
A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Barbiturates; Chloroquine; Coordination C | 2020 |
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Autophagy; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation | 2021 |
Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3.
Topics: Adult; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Bone Neoplasms; Cell Proliferation; Ch | 2021 |
Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance.
Topics: Alarmins; Animals; Apoptosis; Autophagy; Cell Communication; Cell Line, Tumor; Chloroquine; Dendriti | 2018 |
Metastatic cells are preferentially vulnerable to lysosomal inhibition.
Topics: Animals; Cell Line, Tumor; Chloroquine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neopl | 2018 |
PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Cisplatin | 2019 |
Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.
Topics: Animals; Autophagy; Carcinoma, Pancreatic Ductal; Cell Communication; Cell Line, Tumor; Cell Movemen | 2019 |
Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition.
Topics: Autophagy; Autophagy-Related Protein 7; Autophagy-Related Proteins; Carcinoma, Hepatocellular; Cell | 2013 |
Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy.
Topics: Adenocarcinoma; Apoptosis; Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; Chloroquine; Dose | 2014 |
How to teach an old dog new tricks: autophagy-independent action of chloroquine on the tumor vasculature.
Topics: Animals; Antimalarials; Autophagy; Chloroquine; Endosomes; Gene Deletion; Humans; Hypoxia; Mice; Neo | 2014 |
Chloroquine exerts anti-metastatic activities under hypoxic conditions in cholangiocarcinoma cells.
Topics: Angiogenesis Inhibitors; Cadherins; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Chloroquine; Chol | 2015 |
BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neopla | 2015 |
The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Carboplat | 2016 |
Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroqu | 2016 |
Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model.
Topics: Animals; Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Cyclooxygenase 2; Female; Gene Exp | 2016 |
Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Mice; Neoplasm Metast | 2017 |
Disruption of lysosome function promotes tumor growth and metastasis in Drosophila.
Topics: Animals; Chloroquine; Crosses, Genetic; Drosophila; Genotype; Green Fluorescent Proteins; Humans; Ly | 2010 |
Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 9; Cell Cycle; Cell | 2010 |
Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: potential implications for the treatment of a therapeutic-resistant malignancy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Chloroquine; Gene Expression Regulation, Neopl | 2011 |
Neutral proteinase inhibitors and antimetastatic effects in mice.
Topics: Animals; Aurintricarboxylic Acid; Chloroquine; Indomethacin; Lung Neoplasms; Mice; Mice, Inbred C57B | 1980 |
Tumor- and drug-induced cutaneous neuro-phospholipidosis.
Topics: Adult; Aged; Analgesics; Axons; Carcinoma, Bronchogenic; Chloroquine; Ergotamine; Female; Humans; Li | 1975 |
Malaria complicating neoplastic disease.
Topics: Adult; Antibodies; Antibody Formation; Chloroquine; Colonic Neoplasms; Female; Hemostasis, Surgical; | 1976 |
Metastasis-associated murine melanoma cell surface galactosyltransferase: characterization of enzyme activity and identification of the major surface substrates.
Topics: Animals; Antigens, CD; Cell Membrane; Chloroquine; Chromatography, Thin Layer; G(M1) Ganglioside; Ga | 1990 |
[Ocular radio isotope scanning. Instrumentation. Vectors. Medothology].
Topics: Chloroquine; Choroiditis; Eye Neoplasms; Fluoresceins; Hemangioma; Humans; Iodine Radioisotopes; Mel | 1974 |
[On the value of chloroquine in the treatment of malignant tumor diseases].
Topics: Adenocarcinoma, Scirrhous; Adult; Aged; Animals; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, E | 1967 |
[Ocular scintigraphy].
Topics: Chloroquine; Choroiditis; Diagnosis, Differential; Eye; Eye Diseases; Eye Neoplasms; Fluoresceins; H | 1974 |
[Resoquine in the therapy of malignant tumors].
Topics: Aged; Chloroquine; Cyclophosphamide; Drug Synergism; Female; Humans; Leg; Lymphatic Metastasis; Lymp | 1972 |
[Use of labelled molecules in the diagnosis and surveillance of melanomas].
Topics: Chloroquine; Eye Neoplasms; Fluoresceins; Fundus Oculi; Humans; Iodine Radioisotopes; Melanoma; Meth | 1973 |
[Conjunction of isotopic vectors in the scintigraphic diagnosis of eye tumors].
Topics: Chloroquine; Eye Neoplasms; Fluoresceins; Humans; Iodine Radioisotopes; Melanoma; Methods; Neoplasm | 1973 |
Sequential liver scanning.
Topics: Adult; Breast Neoplasms; Chloroquine; Colonic Neoplasms; Dactinomycin; Emetine; Estrogens; Female; F | 1969 |
[Use of a new iodated vector (labelled iodoquine) in the diagnosis of nevocarcinoma].
Topics: Adult; Aged; Chloroquine; Female; Humans; Iodine Radioisotopes; Melanoma; Methods; Middle Aged; Neop | 1971 |