chloroquine has been researched along with Metabolic Syndrome in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine was also postulated to enhance insulin sensitivity, which suggests potential benefit in treating the metabolic syndrome-related erectile dysfunction." | 6.44 | Chloroquine-induced nitric oxide as a potential treatment of erectile dysfunction associated with the metabolic syndrome: the science and the fiction. ( Ahmed, MH, 2007) |
| "Chloroquine was also postulated to enhance insulin sensitivity, which suggests potential benefit in treating the metabolic syndrome-related erectile dysfunction." | 2.44 | Chloroquine-induced nitric oxide as a potential treatment of erectile dysfunction associated with the metabolic syndrome: the science and the fiction. ( Ahmed, MH, 2007) |
| "Chloroquine has a protective effect on the prevalence of metabolic syndrome in these patients, and this benefit counteracts the deleterious effect of glucocorticoids in a dose-dependent manner." | 1.42 | Impact of Therapy on Metabolic Syndrome in Young Adult Premenopausal Female Lupus Patients: Beneficial Effect of Antimalarials. ( Bonfá, E; Borba, EF; Muniz, LF; Pereira, RMR; Silva, TF, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, SK | 1 |
| González-Estrada, A | 2 |
| Gomez-Morales, LB | 1 |
| García-Morillo, JS | 1 |
| Muniz, LF | 1 |
| Pereira, RMR | 1 |
| Silva, TF | 1 |
| Bonfá, E | 1 |
| Borba, EF | 1 |
| Lee, LS | 1 |
| Leow, MK | 1 |
| Xu, Y | 1 |
| Wilder-Smith, A | 1 |
| Cheung, YB | 1 |
| Paton, NI | 1 |
| Shoelson, SE | 1 |
| Ahmed, MH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Using Hydroxychloroquine to Treat Nonalcoholic Steatohepatitis[NCT05733897] | 150 participants (Anticipated) | Observational | 2022-06-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for chloroquine and Metabolic Syndrome
| Article | Year |
|---|---|
Repurposing New Use for Old Drug Chloroquine against Metabolic Syndrome: A Review on Animal and Human Evidence.
Topics: Animals; Apoptosis; Autophagy; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclinical; Dr | 2021 |
Banking on ATM as a new target in metabolic syndrome.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Atherosclerosis; Cell Cycle Proteins; Chloroquine; | 2006 |
Chloroquine-induced nitric oxide as a potential treatment of erectile dysfunction associated with the metabolic syndrome: the science and the fiction.
Topics: Chloroquine; Erectile Dysfunction; Humans; Male; Metabolic Syndrome; Nitric Oxide | 2007 |
1 trial available for chloroquine and Metabolic Syndrome
| Article | Year |
|---|---|
Low-dose chloroquine is associated with favourable effects on lipoprotein metabolism without significant influence on insulin resistance.
Topics: Adult; Blood Glucose; Chloroquine; Cholesterol; Dose-Response Relationship, Drug; Drug Administratio | 2016 |
2 other studies available for chloroquine and Metabolic Syndrome
| Article | Year |
|---|---|
Sporadic porphyria cutanea tarda: treatment with chloroquine decreases hyperglycemia and reduces development of metabolic syndrome.
Topics: Adolescent; Adult; Chloroquine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglob | 2014 |
Impact of Therapy on Metabolic Syndrome in Young Adult Premenopausal Female Lupus Patients: Beneficial Effect of Antimalarials.
Topics: Adult; Antimalarials; Brazil; Chloroquine; Cross-Sectional Studies; Female; Glucocorticoids; Humans; | 2015 |