chloroquine has been researched along with Melanoma in 61 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cutaneous melanomas frequently metastasize to the brain, with temozolomide (TMZ) plus radiotherapy (RT) offering little control of these lesions." | 7.91 | Trehalose inhibits cell proliferation and amplifies long-term temozolomide- and radiation-induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence. ( Allavena, G; Del Bello, B; Maellaro, E; Miracco, C; Pirtoli, L; Tini, P; Valacchi, G; Volpi, N, 2019) |
| "It has been confirmed that multidrug resistant (MDR) melanoma cells (M14 ADR2) are more sensitive than their wild-type counterparts (M14 WT) to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 7.80 | The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach. ( Agostinelli, E; Arancia, G; Bozzuto, G; Calcabrini, A; Condello, M; Macone, A; Molinari, A; Ohkubo, S; Tempera, G, 2014) |
| "The aim of the present study was to compare the effect of realgar nanoparticles and arsenic trioxide (ATO) on viability, DNA damage, proliferation, autophagy and apoptosis in the human melanoma cell lines BOWES and A375." | 7.80 | Realgar (As4S4) nanoparticles and arsenic trioxide (As2O3) induced autophagy and apoptosis in human melanoma cells in vitro. ( Balaz, P; Bujnakova, Z; Cholujova, D; Duraj, J; Gronesova, P; Hunakova, L; Lee, TC; Pastorek, M; Sedlak, J, 2014) |
| "Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia." | 7.79 | Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013) |
| "Chloroquine (CQ) can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible." | 7.79 | PUMA: a puzzle piece in chloroquine's antimelanoma activity. ( Amaravadi, RK, 2013) |
| " We show that a lysosome-independent activity of chloroquine (CQ) prevents degradation of PUMA protein, promotes apoptosis, and reduces the growth of melanoma xenografts in mice." | 7.79 | Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. ( Androphy, EJ; Kaufmann, WK; Lakhter, AJ; Naidu, SR; Sahu, RP; Sun, Y; Travers, JB, 2013) |
| " We find that leucine deprivation causes the caspase-dependent apoptotic death of melanoma cells because it fails to appropriately activate autophagy." | 7.77 | Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. ( Kim, D; Sabatini, DM; Sheen, JH; Zoncu, R, 2011) |
| "Cucurbitacin B (CuB) is reported to have anti-proliferation effects on a variety of tumors including melanoma, and more effective regimens by combination of this agent with others are under investigation." | 7.77 | Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment. ( He, X; Li, J; Ouyang, D; Xu, L; Zha, Q; Zhang, Y, 2011) |
| "Melanoma is a fatal cancer with a significant feature of resistance to traditional chemotherapeutic drugs and radiotherapy." | 5.72 | Novel chloroquine derivative suppresses melanoma cell growth by DNA damage through increasing ROS levels. ( Chen, X; Li, J; Liu, N; Long, J; Peng, C; Tang, L; Yan, B; Zhang, J, 2022) |
| "Melanoma is one of the most common skin infections, has triggered significant morbidity and mortality across the globe." | 5.72 | In silico-prediction of chloroquine as a multi-targeted drug against CDKN2A signaling network associated with cutaneous malignant melanoma. ( Aqeel, M; Awan, L; Bashir, Z; Jan, Z; Kalsoom, S; Muhammad Ali, G; Munir, A; Nadeem, T; Sadia, H; Saeed, A; Ud Din, S, 2022) |
| "Danusertib is an inhibitor of aurora kinase, and recent studies have shown that danusertib treatment induces autophagy in several types of cancer." | 5.56 | Augmentation of danusertib's anticancer activity against melanoma by blockage of autophagy. ( Dang, J; Jiao, YN; Li, W; Li, YF; Ma, CM; Shang, YY; Wang, Y; Xia, L; Yu, N; Yu, YY, 2020) |
| "Treatment with chloroquine at a dose of 62 mg/kg i." | 5.29 | Antimelanoma activity of chloroquine, an antimalarial agent with high affinity for melanin. ( Fujita, K; Hasegawa, K; Inoue, S; Ito, S; Wakamatsu, K, 1993) |
| "These results suggest that YAP, MEK1/2, and lysosome function are necessary and critical targets for the therapy of GNAQ/11-driven melanoma, and identify trametinib plus hydroxychloroquine as a potential treatment strategy for metastatic uveal melanoma." | 3.96 | Chloroquine Sensitizes ( Blumer, KJ; Dale, KJ; Ghazi, PC; Kinsey, CG; McMahon, M; Odelberg, SJ; Onken, MD; Richards, JR; Sanchez, JMS; Scherzer, MT; Shin, D; Truong, A; Yoo, JH, 2020) |
| "Cutaneous melanomas frequently metastasize to the brain, with temozolomide (TMZ) plus radiotherapy (RT) offering little control of these lesions." | 3.91 | Trehalose inhibits cell proliferation and amplifies long-term temozolomide- and radiation-induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence. ( Allavena, G; Del Bello, B; Maellaro, E; Miracco, C; Pirtoli, L; Tini, P; Valacchi, G; Volpi, N, 2019) |
| " We previously reported that in human melanoma and osteosarcoma cells, autophagy inhibitors, such as 3‑methyladenine and chloroquine increased the sensitivity to apoptosis induced by tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL)." | 3.91 | Autophagy inhibitors regulate TRAIL sensitivity in human malignant cells by targeting the mitochondrial network and calcium dynamics. ( Ochiai, T; Onoe-Takahashi, A; Suzuki-Karasaki, M; Suzuki-Karasaki, Y, 2019) |
| "It has been confirmed that multidrug resistant (MDR) melanoma cells (M14 ADR2) are more sensitive than their wild-type counterparts (M14 WT) to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 3.80 | The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach. ( Agostinelli, E; Arancia, G; Bozzuto, G; Calcabrini, A; Condello, M; Macone, A; Molinari, A; Ohkubo, S; Tempera, G, 2014) |
| "The aim of the present study was to compare the effect of realgar nanoparticles and arsenic trioxide (ATO) on viability, DNA damage, proliferation, autophagy and apoptosis in the human melanoma cell lines BOWES and A375." | 3.80 | Realgar (As4S4) nanoparticles and arsenic trioxide (As2O3) induced autophagy and apoptosis in human melanoma cells in vitro. ( Balaz, P; Bujnakova, Z; Cholujova, D; Duraj, J; Gronesova, P; Hunakova, L; Lee, TC; Pastorek, M; Sedlak, J, 2014) |
| "Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia." | 3.79 | Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013) |
| "Chloroquine (CQ) can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible." | 3.79 | PUMA: a puzzle piece in chloroquine's antimelanoma activity. ( Amaravadi, RK, 2013) |
| " We show that a lysosome-independent activity of chloroquine (CQ) prevents degradation of PUMA protein, promotes apoptosis, and reduces the growth of melanoma xenografts in mice." | 3.79 | Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. ( Androphy, EJ; Kaufmann, WK; Lakhter, AJ; Naidu, SR; Sahu, RP; Sun, Y; Travers, JB, 2013) |
| "Serum-deprived U251 glioma, B16 melanoma and L929 fibrosarcoma cells were treated with chloroquine in vitro." | 3.78 | Chloroquine-mediated lysosomal dysfunction enhances the anticancer effect of nutrient deprivation. ( Arsikin, K; Bumbasirevic, V; Harhaji-Trajkovic, L; Janjetovic, K; Kravic-Stevovic, T; Pantovic, A; Petricevic, S; Ristic, B; Tovilovic, G; Trajkovic, V; Zogovic, N, 2012) |
| " We find that leucine deprivation causes the caspase-dependent apoptotic death of melanoma cells because it fails to appropriately activate autophagy." | 3.77 | Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. ( Kim, D; Sabatini, DM; Sheen, JH; Zoncu, R, 2011) |
| "Cucurbitacin B (CuB) is reported to have anti-proliferation effects on a variety of tumors including melanoma, and more effective regimens by combination of this agent with others are under investigation." | 3.77 | Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment. ( He, X; Li, J; Ouyang, D; Xu, L; Zha, Q; Zhang, Y, 2011) |
| "1) activity of cell-free extracts (TyH) of B16 melanoma cells cultured in the presence of 5 to 10 mM ammonium chloride was considerably higher than that of cells from control cultures." | 3.66 | Stimulation of tyrosinase activity of cultured melanoma cells by lysosomotropic agents. ( Oikawa, A; Saeki, H, 1983) |
| "A marked cutaneous axonal dystrophy has been observed electronmicroscopically for the first time in the skin of three patients: (a) lesion of pityriasis lichenoides chronica in a patient with bronchogenic carcinoma, (b) non involved skin of a patient with malignant melanoma and (c) non involved skin of a patient with gout and retinal damage after prolonged use of chloroquine." | 3.65 | [Tumor- and drug-induced cutaneous axonal dystrophy. An electronmicrocopy proof of multiple lamellated bodies]. ( Orfanos, CE; Runne, U, 1975) |
| " Chloroquine, ergotamine, ethaverine and chronic abuse of non-narcotic analgesic drugs seem to be responsible for the drug-induced cutaneous neuro-phospholipidosis, whereas the same condition was found in two patients with metastatic bronchogenic carcinoma and malignant melanoma." | 3.65 | Tumor- and drug-induced cutaneous neuro-phospholipidosis. ( Orfanos, CE; Runne, U, 1975) |
| " Safety, pharmacokinetics and preliminary efficacy through intratumoural and peritumoural injections of DT01 were evaluated in combination with radiotherapy in a first-in-human phase I trial in patients with unresectable skin metastases from melanoma." | 2.82 | First-in-human phase I study of the DNA-repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma. ( Asselain, B; Avril, MF; Bey, P; Cosset, JM; Devun, F; Dreno, B; Dutreix, M; Dutriaux, C; Grob, JJ; Joly, P; Jouary, T; Kirova, Y; Le Tourneau, C; Lebbé, C; Marty, ME; Maubec, E; Mortier, L; Saiag, P; Sun, JS; Thomas, L, 2016) |
| "Melanoma is a fatal cancer with a significant feature of resistance to traditional chemotherapeutic drugs and radiotherapy." | 1.72 | Novel chloroquine derivative suppresses melanoma cell growth by DNA damage through increasing ROS levels. ( Chen, X; Li, J; Liu, N; Long, J; Peng, C; Tang, L; Yan, B; Zhang, J, 2022) |
| "Melanoma is one of the most common skin infections, has triggered significant morbidity and mortality across the globe." | 1.72 | In silico-prediction of chloroquine as a multi-targeted drug against CDKN2A signaling network associated with cutaneous malignant melanoma. ( Aqeel, M; Awan, L; Bashir, Z; Jan, Z; Kalsoom, S; Muhammad Ali, G; Munir, A; Nadeem, T; Sadia, H; Saeed, A; Ud Din, S, 2022) |
| "Danusertib is an inhibitor of aurora kinase, and recent studies have shown that danusertib treatment induces autophagy in several types of cancer." | 1.56 | Augmentation of danusertib's anticancer activity against melanoma by blockage of autophagy. ( Dang, J; Jiao, YN; Li, W; Li, YF; Ma, CM; Shang, YY; Wang, Y; Xia, L; Yu, N; Yu, YY, 2020) |
| "Treatment with chloroquine at a dose of 62 mg/kg i." | 1.29 | Antimelanoma activity of chloroquine, an antimalarial agent with high affinity for melanin. ( Fujita, K; Hasegawa, K; Inoue, S; Ito, S; Wakamatsu, K, 1993) |
| "Chloroquine treatment of intact cells leads to a 4-fold and a 3-fold increase in galactosylation of the Mr = 110,000 protein and glucosylceramide, respectively, suggesting that these two substrates normally reside mostly in the lysosomal or Golgi compartments." | 1.28 | Metastasis-associated murine melanoma cell surface galactosyltransferase: characterization of enzyme activity and identification of the major surface substrates. ( Hart, GW; Passaniti, A, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (45.90) | 18.7374 |
| 1990's | 4 (6.56) | 18.2507 |
| 2000's | 1 (1.64) | 29.6817 |
| 2010's | 20 (32.79) | 24.3611 |
| 2020's | 8 (13.11) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 9 |
| Long, J | 1 |
| Zhang, J | 4 |
| Liu, N | 1 |
| Yan, B | 1 |
| Tang, L | 1 |
| Chen, X | 2 |
| Peng, C | 1 |
| Fei, X | 1 |
| Xie, X | 2 |
| Qin, R | 1 |
| Wang, A | 1 |
| Meng, X | 1 |
| Sun, F | 1 |
| Zhao, Y | 3 |
| Jiang, D | 1 |
| Chen, H | 2 |
| Huang, Q | 1 |
| Ji, X | 1 |
| Wang, Z | 2 |
| Jan, Z | 1 |
| Aqeel, M | 1 |
| Munir, A | 1 |
| Saeed, A | 1 |
| Sadia, H | 1 |
| Kalsoom, S | 1 |
| Nadeem, T | 1 |
| Bashir, Z | 1 |
| Awan, L | 1 |
| Ud Din, S | 1 |
| Muhammad Ali, G | 1 |
| Shang, YY | 1 |
| Yu, N | 2 |
| Xia, L | 1 |
| Yu, YY | 1 |
| Ma, CM | 1 |
| Jiao, YN | 1 |
| Li, YF | 1 |
| Wang, Y | 3 |
| Dang, J | 1 |
| Li, W | 3 |
| Sciarretta, F | 1 |
| Fulci, C | 1 |
| Palumbo, C | 1 |
| Rotili, D | 1 |
| Tentori, L | 1 |
| Graziani, G | 1 |
| Caccuri, AM | 1 |
| Gil, D | 1 |
| Zarzycka, M | 1 |
| Ciołczyk-Wierzbicka, D | 1 |
| Laidler, P | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 2 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 3 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 2 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, Y | 3 |
| Chen, L | 3 |
| Shan, A | 1 |
| Zhao, H | 2 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Wang, J | 4 |
| Zhang, E | 1 |
| Li, Y | 5 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
| Verani, A | 1 |
| Du, L | 1 |
| Liu, X | 1 |
| Ren, Y | 1 |
| Li, P | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 2 |
| Wang, YS | 1 |
| Wang, C | 3 |
| Zhou, X | 2 |
| Wang, W | 1 |
| Wang, S | 2 |
| Hou, J | 1 |
| Zhang, A | 1 |
| Lv, B | 1 |
| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 1 |
| Zhu, J | 2 |
| Zhang, L | 2 |
| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
| Qu, Y | 1 |
| Yao, H | 1 |
| Wang, X | 5 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Zhao, Q | 1 |
| Hu, W | 1 |
| Zhang, Y | 5 |
| Wu, X | 1 |
| Lu, J | 2 |
| Li, M | 1 |
| Wu, W | 1 |
| Du, F | 1 |
| Ji, H | 1 |
| Yang, X | 2 |
| Xu, Z | 1 |
| Wan, L | 1 |
| Wen, Q | 1 |
| Cho, CH | 1 |
| Zou, C | 1 |
| Xiao, Z | 1 |
| Liao, J | 1 |
| Su, X | 1 |
| Bi, Z | 1 |
| Su, Q | 1 |
| Huang, H | 1 |
| Wei, Y | 2 |
| Gao, Y | 2 |
| Na, KJ | 1 |
| Choi, H | 1 |
| Oh, HR | 1 |
| Kim, YH | 1 |
| Lee, SB | 1 |
| Jung, YJ | 1 |
| Koh, J | 1 |
| Park, S | 1 |
| Lee, HJ | 1 |
| Jeon, YK | 1 |
| Chung, DH | 1 |
| Paeng, JC | 1 |
| Park, IK | 1 |
| Kang, CH | 1 |
| Cheon, GJ | 1 |
| Kang, KW | 1 |
| Lee, DS | 1 |
| Kim, YT | 1 |
| Pajuelo-Lozano, N | 1 |
| Alcalá, S | 1 |
| Sainz, B | 1 |
| Perona, R | 1 |
| Sanchez-Perez, I | 1 |
| Logotheti, S | 1 |
| Marquardt, S | 1 |
| Gupta, SK | 1 |
| Richter, C | 1 |
| Edelhäuser, BAH | 1 |
| Engelmann, D | 1 |
| Brenmoehl, J | 1 |
| Söhnchen, C | 1 |
| Murr, N | 1 |
| Alpers, M | 1 |
| Singh, KP | 1 |
| Wolkenhauer, O | 1 |
| Heckl, D | 1 |
| Spitschak, A | 1 |
| Pützer, BM | 1 |
| Liao, Y | 1 |
| Cheng, J | 1 |
| Kong, X | 1 |
| Li, S | 1 |
| Zhang, M | 4 |
| Zhang, H | 1 |
| Yang, T | 2 |
| Dong, Y | 1 |
| Xu, Y | 1 |
| Yuan, Z | 1 |
| Cao, J | 1 |
| Zheng, Y | 1 |
| Luo, Z | 1 |
| Mei, Z | 1 |
| Yao, Y | 1 |
| Liu, Z | 2 |
| Liang, C | 1 |
| Yang, H | 1 |
| Song, Y | 1 |
| Yu, K | 1 |
| Zhu, C | 1 |
| Huang, Z | 1 |
| Qian, J | 1 |
| Ge, J | 1 |
| Hu, J | 2 |
| Wang, H | 2 |
| Liu, Y | 4 |
| Mi, Y | 1 |
| Kong, H | 1 |
| Xi, D | 1 |
| Yan, W | 1 |
| Luo, X | 1 |
| Ning, Q | 1 |
| Chang, X | 2 |
| Zhang, T | 2 |
| Wang, Q | 2 |
| Rathore, MG | 1 |
| Reddy, K | 1 |
| Shin, SH | 1 |
| Ma, WY | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Mu, W | 1 |
| Liu, C | 3 |
| Gao, F | 1 |
| Qi, Y | 1 |
| Lu, H | 1 |
| Zhang, X | 4 |
| Cai, X | 1 |
| Ji, RY | 1 |
| Hou, Y | 3 |
| Tian, J | 2 |
| Shi, Y | 1 |
| Ying, S | 1 |
| Tan, M | 1 |
| Feng, G | 1 |
| Kuang, Y | 1 |
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2 reviews available for chloroquine and Melanoma
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Driving Cytotoxic Natural Killer Cells into Melanoma: If CCL5 Plays the Music, Autophagy Calls the Shots.
Topics: Adipogenesis; Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Proteins; Biomarkers; Che | 2018 |
4 trials available for chloroquine and Melanoma
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
First-in-human phase I study of the DNA-repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chemoradiotherapy; Chloroquine; Cholesterol; | 2016 |
Diagnostic efficacy of a radioiodinated chloroquine analog in patients with malignant melanoma.
Topics: Brain Neoplasms; Chloroquine; Clinical Trials as Topic; Eye Neoplasms; Humans; Iodine Radioisotopes; | 1970 |
125I-labelled chloroquine analog in the diagnosis of ocular melanomas.
Topics: Autoradiography; Chloroquine; Choroid Neoplasms; Clinical Trials as Topic; Conjunctiva; Eye Neoplasm | 1971 |
56 other studies available for chloroquine and Melanoma
| Article | Year |
|---|---|
Novel chloroquine derivative suppresses melanoma cell growth by DNA damage through increasing ROS levels.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Chloroquine; DNA Damage; Drug Resistance, Neoplasm; | 2022 |
Proteomics analysis: inhibiting the expression of P62 protein by chloroquine combined with dacarbazine can reduce the malignant progression of uveal melanoma.
Topics: Animals; Cell Line, Tumor; Chloroquine; Dacarbazine; Humans; Melanoma; Mice; Mice, Nude; Proteomics; | 2022 |
In silico-prediction of chloroquine as a multi-targeted drug against CDKN2A signaling network associated with cutaneous malignant melanoma.
Topics: Chloroquine; Cyclin-Dependent Kinase Inhibitor p16; Humans; Melanoma; Melanoma, Cutaneous Malignant; | 2022 |
Augmentation of danusertib's anticancer activity against melanoma by blockage of autophagy.
Topics: Animals; Autophagy; Benzamides; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chl | 2020 |
Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells.
Topics: Autophagy; B7-H1 Antigen; Cell Line, Tumor; Chloroquine; Gene Expression Regulation; Glutathione Tra | 2019 |
Integrin linked kinase regulates endosomal recycling of N-cadherin in melanoma cells.
Topics: Cadherins; Cell Line, Tumor; Cell Membrane; Cell Survival; Chloroquine; Endocytosis; Endosomes; Huma | 2020 |
Chloroquine Sensitizes
Topics: Animals; Antimalarials; Apoptosis; Cell Proliferation; Chloroquine; Drug Resistance, Neoplasm; Drug | 2020 |
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Autophagy; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation | 2021 |
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Topics: Animals; Antimalarials; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Proliferation; Chlo | 2017 |
Novel organometallic chloroquine derivative inhibits tumor growth.
Topics: Animals; Antimalarials; Apoptosis; Cell Proliferation; Chloroquine; Drug Resistance, Neoplasm; Femal | 2018 |
Trehalose inhibits cell proliferation and amplifies long-term temozolomide- and radiation-induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Chloroquine; Drug R | 2019 |
Autophagy inhibitors regulate TRAIL sensitivity in human malignant cells by targeting the mitochondrial network and calcium dynamics.
Topics: Autophagy; Biomarkers, Tumor; Bone Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Su | 2019 |
Inhibition of autophagy with chloroquine is effective in melanoma.
Topics: Antibiotics, Antineoplastic; Antimalarials; Autophagy; Benzoquinones; Cell Line, Tumor; Chloroquine; | 2013 |
PUMA: a puzzle piece in chloroquine's antimelanoma activity.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Chloroquine; Humans; Melanoma; Proto-Oncogene Pro | 2013 |
Dynamic interplay between autophagic flux and Akt during melanoma progression in vitro.
Topics: Autophagy; Cell Line, Tumor; Chloroquine; Disease Progression; Humans; In Vitro Techniques; Melanocy | 2014 |
Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib.
Topics: Acridines; Animals; Antimalarials; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Proto | 2014 |
The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cells, Cultured; Chloroquine; | 2014 |
Realgar (As4S4) nanoparticles and arsenic trioxide (As2O3) induced autophagy and apoptosis in human melanoma cells in vitro.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Aut | 2014 |
The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.
Topics: Acetylcysteine; Antigen Presentation; Antigens, Neoplasm; Autophagy; Autophagy-Related Protein 12; C | 2016 |
Autophagy inhibitors chloroquine and LY294002 enhance temozolomide cytotoxicity on cutaneous melanoma cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Prolife | 2017 |
NF-κB Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance.
Topics: Animals; Antimalarials; Antineoplastic Agents; Autophagosomes; Autophagy; Carcinoma, Squamous Cell; | 2017 |
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Autophagy; Caspase 3; Cell Line, Tumor; Chloroquine; Humans; Leucine | 2011 |
Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment.
Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Drug Synergism; Histone Deacetylase In | 2011 |
Chloroquine-mediated lysosomal dysfunction enhances the anticancer effect of nutrient deprivation.
Topics: Animals; Antimalarials; Caloric Restriction; Cell Death; Cell Line, Tumor; Cell Survival; Chloroquin | 2012 |
Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation.
Topics: Animals; Antimalarials; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Chloroquine | 2013 |
Stimulation of tyrosinase activity of cultured melanoma cells by lysosomotropic agents.
Topics: Ammonium Chloride; Animals; Catechol Oxidase; Cell Line; Chloroquine; Cycloheximide; Ethylamines; Hy | 1983 |
Mechanism of autodegradation of cell-surface macromolecules shed by human melanoma cells.
Topics: Ammonium Chloride; Biological Transport; Cadaverine; Cell Line; Chloroquine; Coated Pits, Cell-Membr | 1984 |
[Influence of x-rays and quinacrine (atebrine) or chloroquine (resochine)--alone or in combination--on growth and melanin formation of Harding-Passey melanoma cells in monolayer culture].
Topics: Cell Survival; Cells, Cultured; Chloroquine; Dose-Response Relationship, Radiation; Melanins; Melano | 1982 |
Antimelanoma activity of chloroquine, an antimalarial agent with high affinity for melanin.
Topics: Animals; Antimalarials; Antineoplastic Agents; Chloroquine; Chromatography, High Pressure Liquid; Do | 1993 |
Tumor cell retention of antibody Fab fragments is enhanced by an attached HIV TAT protein-derived peptide.
Topics: Amino Acid Sequence; Biological Transport; Carbon Radioisotopes; Cell Membrane; Chloroquine; Colonic | 1993 |
The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites.
Topics: Adult; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Bridged Bicyclo Compounds, Heteroc | 1995 |
Rheumatoid arthritis induced by alpha-interferon therapy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chloroquine; Drug Therapy, Co | 2001 |
[Tumor- and drug-induced cutaneous axonal dystrophy. An electronmicrocopy proof of multiple lamellated bodies].
Topics: Adult; Aged; Axons; Bronchial Neoplasms; Chloroquine; Cytoplasm; Drug Hypersensitivity; Female; Gout | 1975 |
Tumor- and drug-induced cutaneous neuro-phospholipidosis.
Topics: Adult; Aged; Analgesics; Axons; Carcinoma, Bronchogenic; Chloroquine; Ergotamine; Female; Humans; Li | 1975 |
Radionuclidic explorations in ophthalmology.
Topics: Chloroquine; Diabetic Retinopathy; Eye Neoplasms; Fluoresceins; Glaucoma; Hemangioma; Humans; Iodine | 1975 |
Metastasis-associated murine melanoma cell surface galactosyltransferase: characterization of enzyme activity and identification of the major surface substrates.
Topics: Animals; Antigens, CD; Cell Membrane; Chloroquine; Chromatography, Thin Layer; G(M1) Ganglioside; Ga | 1990 |
Chloroquine as a hyperthermia potentiator.
Topics: Cell Survival; Chloroquine; Hyperthermia, Induced; Melanoma; Temperature; Time Factors; Tumor Cells, | 1989 |
Potential radiopharmaceuticals for the detection of ocular melanoma. Part II. Iodoquinoline derivatives and 67Ga-citrate.
Topics: Aminoquinolines; Animals; Chloroquine; Cricetinae; Eye Neoplasms; Gallium Radioisotopes; Humans; Iod | 1986 |
[Ultrastructural studies of the effect of x-rays and quinacrine (Atebrin) or chloroquine (Resochin)--alone or in combination--on Harding-Passey melanoma cells in monolayer culture].
Topics: Animals; Chloroquine; Combined Modality Therapy; In Vitro Techniques; Melanoma; Mice; Microscopy, El | 1985 |
Accumulation of drugs on melanin.
Topics: Animals; Autoradiography; Carbon Isotopes; Catechol Oxidase; Catecholamines; Cattle; Chloroquine; Ch | 1973 |
Inhibiting effect of chloroquine diphosphate on the growth of tumors and activity of some acid hydrolases of a melanotic melanoma in golden hamsters (Mesocricetus auratus, Waterhouse).
Topics: Acid Phosphatase; Animals; Catechol Oxidase; Catechols; Cathepsins; Chloroquine; Cricetinae; Liver; | 1973 |
[Ocular radio isotope scanning. Instrumentation. Vectors. Medothology].
Topics: Chloroquine; Choroiditis; Eye Neoplasms; Fluoresceins; Hemangioma; Humans; Iodine Radioisotopes; Mel | 1974 |
[Ocular scintigraphy].
Topics: Chloroquine; Choroiditis; Diagnosis, Differential; Eye; Eye Diseases; Eye Neoplasms; Fluoresceins; H | 1974 |
[Resoquine in the therapy of malignant tumors].
Topics: Aged; Chloroquine; Cyclophosphamide; Drug Synergism; Female; Humans; Leg; Lymphatic Metastasis; Lymp | 1972 |
Effect of x-irradiation on melanosomal tyrosinase activity.
Topics: Animals; Catechol Oxidase; Chloroquine; Melanocytes; Melanoma; Mice; Neoplasm Transplantation; Neopl | 1973 |
Enhancement of the radiation response of cultured tumor cells by chloroquine.
Topics: Carbon Isotopes; Cell Line; Chloroquine; Female; HeLa Cells; Humans; Lung; Melanoma; Neoplasms, Expe | 1973 |
[Use of labelled molecules in the diagnosis and surveillance of melanomas].
Topics: Chloroquine; Eye Neoplasms; Fluoresceins; Fundus Oculi; Humans; Iodine Radioisotopes; Melanoma; Meth | 1973 |
[Conjunction of isotopic vectors in the scintigraphic diagnosis of eye tumors].
Topics: Chloroquine; Eye Neoplasms; Fluoresceins; Humans; Iodine Radioisotopes; Melanoma; Methods; Neoplasm | 1973 |
[Recent diagnostic and therapeutic acquisitions in malignant melanoma].
Topics: Antineoplastic Agents; Camptothecin; Chloroquine; Colchicine; Humans; Hydroxyurea; Imidazoles; Immun | 1974 |
Regulation of tyrosinase activity in mouse melanoma and skin by changes in melanosomal membrane permeability.
Topics: Animals; Bile Acids and Salts; Catechol Oxidase; Cell Membrane Permeability; Chloroquine; Chlorproma | 1971 |
Effect of chloroquine on malignant lymphoreticular and pigmented cells in vitro.
Topics: Animals; Burkitt Lymphoma; Cell Nucleolus; Cell Nucleus; Chloroquine; Culture Techniques; Cytoplasm; | 1970 |
Radioisotope detection of ocular melanomas.
Topics: Adult; Aged; Child; Chloroquine; Choroid Neoplasms; Diagnosis, Differential; Eye Diseases; Female; H | 1971 |
Treatment doses of 131-I-labeled chloroquine analog in normal and malignant melanoma dogs.
Topics: Animals; Chloroquine; Choroid; Dog Diseases; Dogs; Electroretinography; Eye Neoplasms; Iodine Isotop | 1971 |
[Use of a new iodated vector (labelled iodoquine) in the diagnosis of nevocarcinoma].
Topics: Adult; Aged; Chloroquine; Female; Humans; Iodine Radioisotopes; Melanoma; Methods; Middle Aged; Neop | 1971 |
The effect of DNA repair inhibitors on e response of tumors treated with x-ray and alkylating agents.
Topics: Alkylating Agents; Animals; Bone Marrow; Caffeine; Chloroquine; Cricetinae; Cyclophosphamide; DNA; L | 1971 |
Visualizing human malignant melanoma and metastases. Use of chloroquine analog tagged with iodine 125.
Topics: Adult; Aged; Chloroquine; Feces; Female; Humans; Iodine Radioisotopes; Lymphatic Metastasis; Male; M | 1968 |