chloroquine has been researched along with Malaria in 2908 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tafenoquine, co-administered with chloroquine, is approved for the radical cure (prevention of relapse) of Plasmodium vivax malaria." | 9.69 | Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study. ( Baird, JK; Berni, A; Budiman, W; Cedar, E; Chand, K; Crenna-Darusallam, C; Duparc, S; Ekawati, LL; Elyazar, I; Fernando, D; Fletcher, K; Goyal, N; Green, JA; Instiaty, I; Jones, S; Kleim, JP; Lardo, S; Martin, A; Noviyanti, R; Prasetya, CB; Rolfe, K; Santy, YW; Satyagraha, AW; Sharma, H; Soebandrio, A; Subekti, D; Sutanto, I; Tan, LK; Taylor, M, 2023) |
| "Pyronaridine-artesunate was recently strongly recommended in the 2022 update of the WHO Guidelines for the Treatment of Malaria, becoming the newest artemisinin-based combination therapy (ACT) for both uncomplicated Plasmodium falciparum and Plasmodium vivax malaria." | 9.41 | Pyronaridine: a review of its clinical pharmacology in the treatment of malaria. ( Chu, WY; Dorlo, TPC, 2023) |
| "A randomized controlled trial was conducted in 3 district hospitals in Sabah, Malaysia to compare the efficacy of AL against chloroquine (CQ) for uncomplicated knowlesi malaria." | 9.27 | Artemether-Lumefantrine Versus Chloroquine for the Treatment of Uncomplicated Plasmodium knowlesi Malaria: An Open-Label Randomized Controlled Trial CAN KNOW. ( Anstey, NM; Barber, BE; Chandna, A; Grigg, MJ; Menon, J; Patel, K; Price, RN; Rajahram, GS; Schimann, E; Wilkes, CS; William, T; Yeo, TW, 2018) |
| "Chloroquine administered as intermittent therapy did not provide better protection from malaria and related adverse effects compared with intermittent sulfadoxine-pyrimethamine in a setting of high resistance to sulfadoxine-pyrimethamine." | 9.27 | Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial. ( Boudová, S; Divala, TH; Goswami, J; Kanjala, M; Kennedy, J; Laufer, MK; Masonga, R; Mawindo, PM; Mbilizi, Y; Muehlenbachs, A; Mungwira, RG; Muwalo, F; Mvula, P; Ndaferankhande, M; Ndovie, L; Nyirenda, OM; Potter, GE; Tomoka, T; Tsirizani, LE; Wylie, BJ, 2018) |
| "A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries." | 9.22 | Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review. ( Bwire, GM; Chamani, AT; Mutagonda, RF; Mwakyandile, T; Njiro, BJ; Sabas, D, 2022) |
| " Patients aged 1 year or older with uncomplicated P knowlesi malaria were randomly assigned, via computer-generated block randomisation (block sizes of 20), to receive oral artesunate-mefloquine (target dose 12 mg/kg artesunate and 25 mg/kg mefloquine) or chloroquine (target dose 25 mg/kg)." | 9.22 | Artesunate-mefloquine versus chloroquine for treatment of uncomplicated Plasmodium knowlesi malaria in Malaysia (ACT KNOW): an open-label, randomised controlled trial. ( Anstey, NM; Barber, BE; Dhanaraj, P; Grigg, MJ; McCarthy, JS; Menon, J; Pasay, C; Price, RN; Rajahram, GS; von Seidlein, L; Wilkes, CS; William, T; Yeo, TW, 2016) |
| "Chloroquine has been the treatment of choice for acute vivax malaria for more than 60 years." | 9.22 | Comparison of the safety and efficacy of fixed-dose combination of arterolane maleate and piperaquine phosphate with chloroquine in acute, uncomplicated Plasmodium vivax malaria: a phase III, multicentric, open-label study. ( Anvikar, AR; Arora, S; Gogtay, N; Iyer, SS; Jalali, RK; Kochar, SK; Kumar, NB; Lakhani, JD; Rajadhyaksha, GC; Rao, BH; Roy, A; Saha, N; Savargaonkar, D; Sharma, P; Solanki, BB; Srivastava, B; Tripathi, SK; Valecha, N, 2016) |
| " Asiatic acid suppressed parasitaemia while oral chloroquine (30 mg/kg) did not influence malaria induction." | 9.22 | Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats. ( Mabandla, MV; Mavondo, GA; Mkhwananzi, BN, 2016) |
| "Chloroquine-azithromycin is being evaluated as combination therapy for malaria." | 9.19 | Chloroquine-azithromycin combination antimalarial treatment decreases risk of respiratory- and gastrointestinal-tract infections in Malawian children. ( Claassen, CW; Dzinjalamala, FK; Gilliams, EA; Jumare, J; Laufer, MK; Nyirenda, OM; Plowe, CV; Taylor, T; Thesing, PC; Tracy, LA, 2014) |
| "The predominance of chloroquine-susceptible falciparum malaria in Malawi more than a decade after chloroquine's withdrawal permits contemplation of re-introducing chloroquine for targeted uses." | 9.16 | A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria. ( Dzinjalamala, FK; Laufer, MK; Laurens, MB; Masonga, R; Nyirenda, OM; Plowe, CV; Stokes-Riner, A; Taylor, TE; Thesing, PC, 2012) |
| "To compare the efficacy of monthly SP presumptive treatment, versus weekly chloroquine for malaria prophylaxis in children attending the Sickle Cell Clinic, Mulago Hospital." | 9.14 | Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial. ( Nakiboneka, D; Nakibuuka, V; Ndeezi, G; Ndugwa, CM; Tumwine, JK, 2009) |
| "The in vivo therapeutic efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination was evaluated in the treatment of uncomplicated Plasmodium falciparum malaria and of chloroquine for P." | 9.13 | [Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006]. ( Cortés, LJ; Guerra, AP; Knudson, A; Nicholls, RS; Pérez, MA; Usta, C, 2008) |
| "The study design was an open randomized control trial comparing anaemia incidence among pregnant women on intermittent presumptive treatment of malaria with SP with those on chloroquine (CQ)." | 9.13 | Efficacy of intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine in preventing anaemia in pregnancy among Nigerian women. ( Abiona, TC; Asa, OO; Fatusi, AO; Ijadunola, KT; Onayade, AA, 2008) |
| " The aims were (i) to update our knowledge of the burden of Plasmodium malariae infection and (ii) to assess the therapeutic efficacy of chloroquine for uncomplicated quartan malaria." | 9.12 | Short report: prevalence and chloroquine sensitivity of Plasmodium malariae in Madagascar. ( Barnadas, C; Ménard, D; Picot, S; Rabekotonorina, V; Ralaizandry, D; Ranaivosoa, H; Ratsimbasoa, A; Raveloariseheno, D, 2007) |
| "Atovaquone-proguanil has been shown to be effective and well tolerated for malaria prophylaxis in residents of countries of endemicity and in nonimmune adult travelers, but data about traveling children are limited." | 9.11 | Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study. ( Camus, D; De Boever, EH; Djossou, F; Dutoit, E; Hedgley, C; Høgh, B; Malvy, D; Miller, GB; Roskell, NS; Schilthuis, HJ, 2004) |
| " The high endemicity of malaria in Africa may impact on the efficacy of artemisinin-based combination therapy." | 9.11 | Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. ( Bakyaita, N; Banek, K; Dorsey, G; Kamya, MR; Kilian, A; Kironde, F; Nsobya, SL; Reingold, A; Rosenthal, PJ; Slater, M; Staedke, SG; Talisuna, A; Wabwire-Mangen, F; Yeka, A, 2005) |
| "At a public hospital in Georgetown, Guyana, 44 patients seeking treatment for symptomatic, slide-confirmed malaria were given standard chloroquine (CQ) therapy and followed for 28 days." | 9.10 | Chloroquine for the treatment of uncomplicated malaria in Guyana. ( Baird, JK; Bravet, PP; Carucci, D; Ferrel, M; Hoffman, SL; Martin, GJ; Prout, TM; Rawlins, S; Tamminga, CL; Tiwari, T; Tjaden, J, 2002) |
| "To improve upon the efficacy of primaquine prophylaxis for malaria (94%, Plasmodium falciparum malaria; 85%, Plasmodium vivax malaria), we administered chloroquine (300 mg weekly) in combination with primaquine (30 mg daily) to nonimmune Colombian soldiers during 16 weeks of patrol in a region of endemicity and for a further 1 week in base camp." | 9.09 | Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in nonimmune Colombian soldiers. ( Berman, J; Herrera, R; Padilla, J; Rodriquez, M; Sanchez, J; Soto, J; Toledo, J, 1999) |
| "Consumption of chloroquine (CQ) and subtherapeutic drug levels in blood are considered to be widespread in areas where malaria is endemic." | 9.09 | Concentrations of chloroquine and malaria parasites in blood in Nigerian children. ( Ademowo, OG; Bergqvist, Y; Bienzle, U; Falusi, AG; Grossterlinden, L; May, J; Meyer, CG; Mockenhaupt, FP; Olumese, PE, 2000) |
| "A randomized, double-blind, placebo-controlled trial, which compared the effects of three interventions (weekly chloroquine prophylaxis, daily iron and weekly folic-acid supplementation, and case management of malaria) on congenital malaria, maternal haemoglobin (Hb) and foetal outcome, was conducted among primigravidae resident in Hoima district, Uganda." | 9.09 | Chloroquine prophylaxis, iron/folic-acid supplementation or case management of malaria attacks in primigravidae in western Uganda: effects on congenital malaria and infant haemoglobin concentrations. ( Magnussen, P; Ndyomugyenyi, R, 2000) |
| "Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 9.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
| "We conducted a double-blind, randomized, parallel group study to examine and compare the antipruritic effects of promethazine, niacin, prednisolone and their combination on pruritus induced by chloroquine, in 28 historical itching patients with parasitologically proven malaria fever." | 9.08 | Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine. ( Adebayo, RA; Ajayi, AA; Onayemi, O; Sofowora, GG; Udoh, SJ, 1997) |
| "Immune suppression resulting from prolonged chemoprophylaxis and potential drug-vaccine interaction were investigated within the context of a randomized placebo-controlled trial that compared daily primaquine or weekly chloroquine administration for malaria prevention." | 9.08 | Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis. ( Church, LW; Cryz, SJ; Fryauff, DJ; Hoffman, SL; Mouzin, E; Richards, AL; Subianto, B; Sutamihardja, MA; Widjaja, H, 1998) |
| "In a controlled trial of weekly malaria chemoprophylaxis with chloroquine and pyrimethamine there were no significant differences in type and frequency of severe morbidity during chemoprophylaxis." | 9.07 | Severe morbidity among children in a trial malaria chemoprophylaxis with pyrimethamine or chloroquine in Ibarapa, Nigeria. ( Asuzu, MC; Bamgboye, A; Ogunba, EO; Osunkoya, BO; Oyediran, AB; Topley, E; Williams, AI, 1993) |
| "To determine the effect of chloroquine chemoprophylaxis during pregnancy on birth weights, a randomized trial was carried out in 1987 and 1988 in Banfora, Burkina Faso (West Africa)." | 9.07 | Effect of chloroquine chemoprophylaxis during pregnancy on birth weight: results of a randomized trial. ( Barro, D; Breart, G; Carnevale, P; Cot, M; Roisin, A; Verhave, JP; Yada, A, 1992) |
| "The incidence and nature of pruritus induced by chloroquine and halofantrine were studied in 82 patients with acute malaria and in 40 healthy subjects, using a visual analogue scale for quantitating pruritus." | 9.07 | Halofantrine-induced pruritus amongst subjects who itch to chloroquine. ( Abila, B; Ambakederemo, AW; Ezeamuzie, IC; Igbigbi, PS; Nwaejike, IN, 1991) |
| "Weekly oral chloroquine prophylaxis for malaria has been associated with impaired antibody response to intradermal rabies vaccination." | 9.07 | The effect of chloroquine prophylaxis on yellow fever vaccine antibody response: comparison of plaque reduction neutralization test and enzyme-linked immunosorbent assay. ( Barry, M; Cullen, MR; Patterson, JE; Shope, RE; Tirrell, S, 1991) |
| "One hundred thirty nonimmune subjects living in Yaoundé, Cameroon, completed an 18-month prospective study on the efficacy and safety of weekly chloroquine and daily proguanil (chloroguanide) (Ch-P) in malaria prevention." | 9.07 | Prolonged malaria prophylaxis with chloroquine and proguanil (chloroguanide) in a nonimmune resident population of an endemic area with a high prevalence of chloroquine resistance. ( Fadat, G; Gozal, D; Hengy, C, 1991) |
| "The efficacy of a loading dose of 20 mg of chloroquine per kg of body weight per os given at intervals during the first day was evaluated in 27 patients in Madagascar with Plasmodium falciparum malaria." | 9.07 | Efficacy of a loading dose of oral chloroquine in a 36-hour treatment schedule for uncomplicated plasmodium falciparum malaria. ( Bergqvist, Y; Clavier, F; Frisk-Holmberg, M; Le Bras, J; Lepers, JP; Pussard, E; Raharimalala, L; Verdier, F, 1991) |
| "The efficacy of chlorpheniramine in the prevention of choroquine-induced pruritus was assessed in a trial involving 132 malaria patients with a history of chloroquine-induced pruritus." | 9.07 | The efficacy of piriton on chloroquine-induced pruritus in patients with malaria. ( Mnyika, KS, 1991) |
| "To compare the efficacy and side-effects of two therapeutic regimens for chloroquine-resistant falciparum malaria, a randomized study was carried out in 69 patients in Maputo Central Hospital in 1986-1987." | 9.06 | [Comparative study of sulfadoxine-pyrimethamine and amodiaquine + sulfadoxine-pyrimethamine for the treatment of malaria caused by chloroquine-resistant Plasmodium falciparum in Maputo, Mozambique]. ( Dinis, DV; Schapira, A, 1990) |
| "5 mg base/kg every 6 h) and intramuscular quinine (20 mg salt/kg followed by 10 mg/kg every 12 h) was carried out in 50 Gambian children with severe falciparum malaria." | 9.06 | Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria. ( Brewster, D; Craddock, C; Krishna, S; Kwiatkowski, D; Waller, D; White, NJ, 1989) |
| "In Nigeria chloroquine remains the drug of choice for the treatment of falciparum malaria since chloroquine resistance is not yet a problem." | 9.06 | Comparison of the susceptibility of falciparum malaria to mefloquine-sulphadoxine-pyrimethamine and chloroquine in Nigeria. ( Aina Adio, R; Fadeke Aderounmu, A; Laoye, AJ; Modupe Makinde, J; Salako, LA, 1988) |
| "Halofantrine hydrochloride given to 46 Kenyan children with falciparum malaria at 10 mg/kg for two doses, and to 60 other children at 8 mg/kg for three doses, resulted in rapid parasite clearance, mean parasite clearance times being 45." | 9.06 | Efficacy of multiple-dose halofantrine in treatment of chloroquine-resistant falciparum malaria in children in Kenya. ( Gilles, HM; Kariuki, D; Koech, DK; Lury, JD; Mjomba, M; Mosoba, M; Oloo, JA; Watkins, WM, 1988) |
| "A randomized double blind study in long term malaria chemoprophylaxis was performed to compare the tolerability of Fansimef (1 tablet containing 250 mg mefloquine + 500 mg sulfadoxine + 25 mg pyrimethamine per week) with chloroquine (300 mg per week)." | 9.06 | Tolerability of long-term malaria prophylaxis with the combination mefloquine + sulfadoxine + pyrimethamine (Fansimef): results of a double blind field trial versus chloroquine in Nigeria. ( Kollaritsch, H; Kollaritsch, R; Kremsner, P; Leimer, R; Mailer, H; Stemberger, H; Wiedermann, G, 1988) |
| " Fifty cases of falciparum malaria were treated with 1800 mg amodiaquine for 3 days: the cure rate was 65." | 9.06 | Effectiveness of amodiaquine, sulfadoxine-pyrimethamine, and combinations of these drugs for treating chloroquine-resistant falciparum malaria in Hainan Island, China. ( Cai, XZ; Fu, SG; Huang, JK; Huang, OL; Ouyang, WC; Pang, XJ; Wang, XF; Wu, Z; Zhang, KY; Zhou, JX, 1988) |
| "Chloroquine (25 mg/kg over 3 d) was compared to quinine (10 mg/kg 3 times daily for 5 d) in 20 adult Filipino males with uncomplicated Plasmodium falciparum malaria in a double-blind, randomized trial." | 9.06 | Chloroquine and quinine: a randomized, double-blind comparison of efficacy and side effects in the treatment of Plasmodium falciparum malaria in the Philippines. ( Alban, P; Long, GW; Padre, LP; Ranoa, CP; Sangalang, R; Watt, G, 1988) |
| "The sensitivity of Plasmodium falciparum to quinine in Nigeria was examined in vivo and in vitro prior to the re-introduction of the drug into malaria therapy in that country in the face of spreading chloroquine resistance in Africa." | 9.06 | Evaluation of the sensitivity in vivo and in vitro of Plasmodium falciparum malaria to quinine in an area of full sensitivity to chloroquine. ( Laoye, OJ; Salako, LA; Sowunmi, A, 1988) |
| "As malaria caused by Plasmodium falciparum has become resistant to chloroquine alternative drug regimens need to be developed." | 9.06 | Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine. ( Bygbjerg, IC; Fogh, S; Gøtzsche, PC; Jepsen, S; Kuijlen, K; Mordhorst, CH; Ravn, P; Rønn, A; Schapira, A, 1988) |
| "We studied the effects of daily proguanil compared to weekly chloroquine as malaria prophylaxis in 170 children living in a malaria-endemic area along the Thai-Burmese border." | 9.06 | Malaria prophylaxis with proguanil in children living in a malaria-endemic area. ( Limsomwong, N; Pang, LW; Singharaj, P, 1988) |
| "The standard chloroquine treatment for Plasmodium falciparum malaria is 25 mg (base)/kg (C25) given over 3 days." | 9.06 | Parasitologic and clinical efficacy of 25 and 50 mg/kg of chloroquine for treatment of Plasmodium falciparum malaria in Rwandan children. ( Bugilimfura, L; Deloron, P; Neill, M; Ntilivamunda, A; Sexton, JD, 1988) |
| "Mefloquine is a highly effective drug for the treatment of falciparum malaria among adults, but studies of its effects on children are lacking." | 9.06 | A phase-III clinical trial of mefloquine in children with chloroquine-resistant falciparum malaria in Thailand. ( Attanath, P; Chantavanich, P; Chongsuphajaisiddhi, T; Sabchareon, A; Sheth, UK; Singhasivanon, V; Wernsdorfer, WH, 1987) |
| "Adults with malaria in Sri Lanka were treated with parenteral chloroquine diphosphate, either 2." | 9.06 | Divided dose intramuscular regimen and single dose subcutaneous regimen for chloroquine: plasma concentrations and toxicity in patients with malaria. ( Abeysekera, DT; Dissanayaka, P; Edwards, G; Galagedera, Y; Phillips, RE; Theakston, RD; Warrell, DA, 1986) |
| "There is no information and therefore no consensus on how chloroquine should be administered to persons with severe malaria." | 9.06 | Parenteral chloroquine for treating falciparum malaria. ( Bergqvist, Y; Njelesani, EK; Watt, G; White, NJ, 1987) |
| "Amodiaquine was compared to chloroquine in two groups of Filipino patients with uncomplicated falciparum malaria." | 9.06 | Amodiaquine less effective than chloroquine in the treatment of falciparum malaria in the Philippines. ( Alban, P; Laughlin, LW; Long, GW; Padre, L; Ranoa, CP; Sangalang, R; Watt, G, 1987) |
| "Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been commonly used for the treatment and prevention of malaria, and the treatment of autoimmune diseases for several decades." | 9.05 | Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19. ( Chen, ZS; Dong, S; Ke, Z; Lei, ZN; Wu, ZX; Yang, DH; Zhang, L; Zou, C, 2020) |
| "The study was carried out to assess the efficacy of quinine in children with Falciparum malaria in relation to in vitro sensitivity (measured in terms of minimum inhibitory concentration: MIC) and to trough serum levels of quinine during the course of treatment." | 9.05 | In vivo and in vitro sensitivity of Falciparum malaria to quinine in Thai children. ( Attanath, P; Chongsuphajaisiddhi, T; Sabcharoen, A, 1981) |
| "A double-blind, randomized, dose-finding, phase II mefloquine trial was carried out in 147 adult male patients suffering from acute, uncomplicated, falciparum malaria and admitted to the Hospital for Tropical Diseases, Bangkok, between January 1980 and April 1981." | 9.05 | A phase II clinical trial of mefloquine in patients with chloroquine-resistant falciparum malaria in Thailand. ( Bunnag, D; Harinasuta, T; Wernsdorfer, WH, 1983) |
| "A total of 99 male Zambian patients with symptomatic falciparum malaria were treated in a double-blind randomized manner with either mefloquine (1000 mg given in one day) or chloroquine (1500 mg given over 3 days)." | 9.05 | A double-blind comparative clinical trial of mefloquine and chloroquine in symptomatic falciparum malaria. ( Kofi Ekue, JM; Rwabwogo-Atenyi, J; Sheth, UK; Ulrich, AM, 1983) |
| "A clinical trial of malaria prophylaxis using a single dose of chloroquine at different intervals was carried out to determine if chloroquine could be given at intervals longer than advocated." | 9.05 | A clinical trial of malaria prophylaxis using a single dose of chloroquine at different intervals in an endemic malarious area. ( Karunakaran, CS, 1980) |
| "Chloroquine-resistant Plasmodium falciparum malaria is increasing in prevelance in Papua New Guinea and alternative therapies for acute malaria are being sought." | 9.05 | Sulfadoxine-pyrimethamine for the treatment of acute malaria in children in Papua New Guinea. I. Plasmodium falciparum. ( Alpers, M; Darlow, B; Gibney, S; Jolley, D; Stace, J; Vrbova, H, 1982) |
| "Responses of parasitemia and fever in vivax malaria to standard doses of chloroquine and different dosage schedules of co-trimoxazole were compared in 165 children." | 9.05 | A comparative trial of oral chloroquine and oral co-trimoxazole in vivax malaria in children. ( Lal, H, 1982) |
| " In one trial mefloquine was compared with chloroquine in 40 patients with Plasmodium vivax malaria and in the other one mefloquine was compared with MSP in 40 patients with P falciparum malaria." | 9.05 | Trials of mefloquine in vivax and of mefloquine plus 'fansidar' in falciparum malaria. ( Bunnag, D; Harinasuta, T; Lasserre, R; Leimer, R; Vinijanont, S, 1985) |
| "The immune response of 198 young Nigerian children protected against malaria by chemoprophylaxis with chloroquine to immunization with triple, poliomyelitis, measles, typhoid, meningococcal and BCG vaccines was compared with the immune response to vaccination of 185 control children." | 9.05 | Malaria chemoprophylaxis with chloroquine in young Nigerian children. II. Effect on the immune response to vaccination. ( Bartlett, A; Bidwell, DE; Bradley, AK; Bradley-Moore, AM; Craske, J; Gilles, HM; Greenwood, BM; Kirkwood, BR; Voller, A, 1985) |
| "Haematological measurements were made in 198 Nigerian children aged three months to two years who received weekly malaria chemoprophylaxis with chloroquine from shortly after birth until the age of one or two years and in 185 age-matched control children." | 9.05 | Malaria chemoprophylaxis with chloroquine in young Nigerian children. IV. Its effect on haematological measurements. ( Akintunde, A; Attai, ED; Bradley, AK; Bradley-Moore, AM; Fleming, AF; Flynn, FV; Gilles, HM; Greenwood, BM; Kirkwood, BR, 1985) |
| "A clinical field trial was conducted to determine if mefloquine is effective in the treatment of malaria due to Plasmodium vivax." | 9.05 | A clinical trial of mefloquine in the treatment of Plasmodium vivax malaria. ( Dixon, KE; Phintuyothin, P; Pitaktong, U, 1985) |
| "Forty-six patients with Plasmodium vivax malaria were evaluated for their clinical and parasitological response to the two single doses of mefloquine in comparison with the standard 3-day treatment with chloroquine." | 9.05 | A comparative clinical study of mefloquine and chloroquine in the treatment of vivax malaria. ( Alcantara, AK; Cross, JH; Sangalang, RP; Uylangco, CV, 1985) |
| "The nutrition of a group of Nigerian children who received weekly chemoprophylaxis with chloroquine during their first one or two years of life was compared with the nutrition of a group of children exposed frequently to malaria." | 9.05 | Malaria chemoprophylaxis with chloroquine in young Nigerian children. III. Its effect on nutrition. ( Bradley, AK; Bradley-Moore, AM; Gilles, HM; Greenwood, BM; Kirkwood, BR, 1985) |
| "Two field trials to detect chloroquine-resistant malaria were conducted according to WHO recommendations in a malaria free area near Rangoon." | 9.04 | Chloroquine-resistant malaria in Burma. ( Hlaing, N; Htun Nyun, R; Kyi, KK; Myint, T; Tin, F; U, T, 1975) |
| "A trial of suppression of malaria by administration of combined sulphadoxine-pyrimethamine tablets every 28 days was undertaken in West Malaysia during 1972." | 9.04 | Suppression of malaria with monthly administration of combined sulphadoxine and pyrimethamine. ( Lewis, AN; Ponnampalam, JT, 1975) |
| "Amodiaquine cured 38% (13/34) of patients with falciparum malaria in Southeast Thailand." | 9.04 | Amodiaquine resistant falciparum malaria in Thailand. ( Hall, AP; Kosakal, S; Pearlman, EJ; Phintuyothin, P; Segal, HE, 1975) |
| "Chloroquine (CQ) is an antimalarial drug that elicits severe pruritus in black Africans with malaria fever." | 9.01 | Itching, chloroquine, and malaria: a review of recent molecular and neuroscience advances and their contribution to mechanistic understanding and therapeutics of chronic non-histaminergic pruritus. ( Ajayi, AAL, 2019) |
| "Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure')." | 8.98 | Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. ( Ashley, EA; Recht, J; White, NJ, 2018) |
| "Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing history as potent antimalarial agents." | 8.91 | Quinoline-based antimalarial hybrid compounds. ( D'hooghe, M; Vandekerckhove, S, 2015) |
| "Coartem(®), the combination of artemether (an artemisinin derivative) and lumefantrine, has been adopted as the first-line treatment for uncomplicated malaria in many countries." | 8.88 | Update on the in vivo tolerance and in vitro reduced susceptibility to the antimalarial lumefantrine. ( Al-Thukair, A; Nzila, A; Ohuma, E; Okombo, J, 2012) |
| "Recent publication have provided strong evidence that activity and cellular uptake of 4-aminoquinoline antimalarials depends on vacuolar haemoglobin degradation and that haematin is the drug target." | 8.81 | Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials. ( Egan, TJ, 2001) |
| "The development of chloroquine as an antimalarial drug and the subsequent evolution of drug-resistant Plasmodium strains had major impacts on global public health in the 20th century." | 8.81 | Chloroquine-resistant malaria. ( Plowe, CV; Wellems, TE, 2001) |
| "Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever." | 8.81 | Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2001) |
| "Chloroquine is a drug with over 60 years of safe clinical use in the treatment of malaria." | 8.81 | [Chloroquine--miscellaneous properties of the antimalarial drug]. ( Jarzyna, R, 2002) |
| "The malarial parasite manifests unique features of heme metabolism." | 8.80 | Heme metabolism of Plasmodium is a major antimalarial target. ( Padmanaban, G; Rangarajan, PN, 2000) |
| "A meta-analysis study evaluating the efficacy and safety of chloroquine and alternative antimalarial drugs used in six African countries including Ethiopia, Kenya, Uganda, Cote D'Ivoire, Gambia and Nigeria is presented." | 8.80 | Comparative efficacy and safety of chloroquine and alternative antimalarial drugs: a meta-analysis from six African countries. ( Makonnen, E; Mengesha, T, 1999) |
| "Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever." | 8.80 | Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2000) |
| "Chloroquine maculopathy is a major complication observed during prophylactic treatment of malaria." | 8.79 | [Chloroquine maculopathy and prevention of malaria]. ( Balo, KP; Mensah, A; Mihluedo, H, 1996) |
| "The mechanisms whereby the intrinsic pruritogenic effect of chloroquine (a property also encountered among some other 4-amino-quinolines including amodiaquine) becomes aggravated during paroxysmal malarial suppressive chemotherapy with the drug form the basis of this paper." | 8.77 | Mechanisms of enhanced pruritogenicity of chloroquine among patients with malaria: a review. ( Osifo, NG, 1989) |
| "Spreading from 2 countries in 1978 to at least 29 in 1988, chloroquine-resistant Plasmodium falciparum malaria has become a significant concern for travelers to Africa." | 8.77 | The spread of chloroquine-resistant malaria in Africa. Implications for travelers. ( Bernard, KW; Moran, JS, 1989) |
| "A review of all available evidence supports the hypothesis that FP is the receptor for chloroquine and mediator of its antimalarial activity." | 8.77 | Ferriprotoporphyrin IX: role in chloroquine susceptibility and resistance in malaria. ( Fitch, CD, 1989) |
| "The efficacy of chloroquine treatment for vivax malaria has been rarely evaluated due to a lack of an appropriate testing method." | 8.31 | Molecular surveillance of chloroquine resistance in Plasmodium vivax isolates from malaria cases in Yunnan Province of China using pvcrt-o gene polymorphisms. ( Chen, M; Deng, Y; Ding, H; Dong, Y; Lin, Y; Liu, L; Liu, Y; Wu, J; Xu, Y; Zhang, C, 2023) |
| "A series of heterocyclic chloroquine hybrids containing either a β-phenethylamine fragment or a 2-aminoindane moiety were synthesized and screened in vitro as inhibitors of β-hematin formation and in vivo for their antimalarial activity against chloroquine-sensitive strains of Plasmodium berghei ANKA." | 8.12 | Synthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity. ( Ángel, JE; Charris, JE; Fernandez-Moreira, E; Mijares, MR; Ramírez, H; Rodrigues, JR, 2022) |
| "Artesunate-amodiaquine (ASAQ) and Artemether-lumefantrine (AL) are the recommended treatment for uncomplicated Plasmodium falciparum malaria in Liberia." | 8.12 | Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers. ( Asinya, M; Jeuronlon, MK; Kamara, P; Koko, VS; Kollie, A; Ma, L; Menard, D; Nyansaiye, P; Parwon, S; Pratt, OJ; Ringwald, P; Taweh, F; Tehmeh, L; Vonhm, B; Warsame, M, 2022) |
| "We developed a novel clickable, photo-affinity chloroquine analog probe (CQP) which retains the antimalarial activity in the nanomole range, and identified a total of 40 proteins that specifically interacted and photo-crosslinked with CQP which was inhibited in the presence of excess CQ." | 8.12 | Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA. ( Chen, JY; Dai, LY; Gao, P; Gu, LW; Guo, QY; Li, ZJ; Liu, YQ; Meng, YQ; Shi, QL; Tang, H; Wang, JG; Xia, F; Xiao, W; Xu, CC; Yang, F; Zhang, JZ; Zhang, Q; Zhang, Y; Zheng, LH; Zhu, YP, 2022) |
| "Based on reports of parasite resistance and on World Health Organization recommendation, chloroquine was replaced with the artemisinin-based combination therapies (ACTs) as the first choice of drugs for the treatment of uncomplicated malaria." | 8.02 | Treatment of COVID-19 with Chloroquine: Implication for Malaria Chemotherapy Using ACTs in Disease Endemic Countries. ( Duah-Quashie, NO; Quashie, NB, 2021) |
| "The quest for the development of a novel antimalarial drug informed the decision to subject phytol to in vivo trials following a demonstration of therapeutic potential against chloroquine sensitive strain of Plasmodium falciparum under in vitro condition." | 8.02 | Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei. ( Abubakar, MS; Adamu, A; Ibrahim, MA; Salman, AA; Usman, FI; Usman, MA, 2021) |
| "We reviewed the clinical efficacy of chloroquine for Plasmodium vivax malaria, the changing trend of parasite clearance time, and fever clearance time during 2000-2016 in South Korea." | 7.96 | Increasing Malaria Parasite Clearance Time after Chloroquine Therapy, South Korea, 2000-2016. ( Cho, SH; Kwak, YG; Lee, KS; Lee, SE; Park, SY; Park, Y; Park, YS; Shin, HI; Song, JE; Yeom, JS, 2020) |
| "Treatment Failure with chloroquine is one of the challenges that faced the dedicated efforts to eradicate malaria This study aims at investigating the impact of treatment failure with chloroquine on the progression of the disease-induced histo-pathogenic and immunogenic outcomes." | 7.96 | Progression of malaria induced pathogenicity during chloroquine therapy. ( Abd Majid, R; Abd Rachman-Isnadi, MF; Basir, R; Bello, RO; Chin, VK; Noor, SM; Sidek, HM; Zaid, OI, 2020) |
| "Antimalarial interventions mostly rely upon drugs, as chloroquine." | 7.88 | In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06. ( Areas, ALL; Bozza, PT; Costa, NF; da Silva Frutuoso, V; de Castro-Faria-Neto, HC; de Lima Ferreira, M; de Souza, MVN; Douradinha, B; Kaiser, CR; Pais, KC; Pereira, MF; Reis, PA; Zalis, MG, 2018) |
| "We describe the first systematic study of antimalarial 1,2,4-trioxolanes bearing a substitution pattern regioisomeric to that of arterolane." | 7.85 | Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. ( Blank, BR; Gut, J; Renslo, AR; Rosenthal, PJ, 2017) |
| "The trans platinum-chloroquine diphosphate dichloride (PtCQ) is a new type of antimalarial drug used to fight parasites resistant to traditional drugs." | 7.85 | Effective-Loading of Platinum-Chloroquine into PEGylated Neutral and Cationic Liposomes as a Drug Delivery System for Resistant Malaria Parasites. ( Ibrahim, S; Ozeki, T; Tagami, T, 2017) |
| " A fixed ratio method based on the SYBR Green I fluorescence-based assay was used to build isobolograms from a combination of cryptolepine with four standard anti-malarial drugs in vitro using the chloroquine sensitive strain 3D7." | 7.85 | In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine. ( Annan, K; Ansah, C; Forkuo, AD; Gyan, B; Mancama, D; Mensah, KB; Theron, A; Wright, CW, 2017) |
| "Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyrazine series led to the identification of highly potent compounds against the blood life-cycle stage of the human malaria parasite Plasmodium falciparum." | 7.83 | Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle. ( Angulo-Barturen, I; Antonova-Koch, Y; Bashyam, S; Birkholtz, LM; Botha, ME; Charman, SA; Chibale, K; Ferrer, S; Gonzàlez Cabrera, D; Han, Z; Jiménez-Díaz, MB; Lawrence, N; Le Manach, C; Martínez, MS; Meister, S; Nchinda, AT; Nondaba, SH; Paquet, T; Reader, J; Street, LJ; Taylor, D; Waterson, D; White, KL; Winzeler, EA; Wittlin, S; Witty, MJ; Younis, Y; Zabiulla, M, 2016) |
| "Co-administration of amodiaquine with MAMA decoction (MD), an herbal antimalarial drug comprising the leaves of Mangifera indica L." | 7.83 | Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model. ( Adepiti, AO; Bolaji, OO; Elujoba, AA, 2016) |
| "Oral Asiatic acid administration influenced %parasitaemia suppression, ameliorated malarial anaemia and increased biophysical properties on infected animals." | 7.83 | Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P. berghei infected Sprague-Dawley male rats. ( Mabandla, MV; Mavondo, GA; Mkhwananzi, BN; Musabayane, CT, 2016) |
| "Faced with intense levels of chloroquine (CQ) resistance in Plasmodium falciparum malaria, Rwanda replaced CQ with amodiaquine (AQ)+sulfadoxine-pyrimethamine (SP) in 2001, and subsequently with artemether-lumefantrine (AL) in 2006, as first-line treatments for uncomplicated malaria." | 7.83 | Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda. ( Grobusch, MP; Hakizimana, E; Kateera, F; Kumar, N; Mens, PF; Mutesa, L; Nsobya, SL; Tukwasibwe, S; van Vugt, M, 2016) |
| "The present study investigated the effects of transdermally delivered oleanolic acid (OA) monotherapy and in combination with chloroquine (CHQ) on malaria parasites and glucose homeostasis of P." | 7.83 | The Effects of Transdermally Delivered Oleanolic Acid on Malaria Parasites and Blood Glucose Homeostasis in P. berghei-Infected Male Sprague-Dawley Rats. ( Mabandla, MV; Musabayane, CT; Sibiya, HP, 2016) |
| "A series of novel aminoalkylated quercetin analogs, prepared via the Mannich reaction of various primary and secondary amines with formaldehyde, were tested for antimalarial activity." | 7.81 | The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs. ( Akoto, M; Avery, VM; Duffy, S; Hagen, TJ; Helgren, TR; Igbinoba, O; Lee, P; Sciotti, RJ, 2015) |
| " The best inhibitors were tested in vivo as potential antimalarials in mice infected with Plasmodium berghei ANKA chloroquine susceptible strain, three of them (11b, 11d and 11h) displayed an antimalarial activity comparable to that of chloroquine." | 7.81 | Synthesis, β-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei. ( Acosta, ME; Charris, JE; Gamboa, N; López, SE; Romero, AH; Salazar, J, 2015) |
| "A novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resistant) and NF54 (sensitive) strains of the malaria parasite Plasmodium falciparum." | 7.81 | Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. ( Chibale, K; Egan, TJ; Jurva, U; Masimirembwa, CM; Njoroge, M; Ongarora, DS; Strydom, N; Wicht, K; Wiesner, L; Wittlin, S, 2015) |
| " In our study, chitosan-tripolyphosphate (CS-TPP) particles was conjugated with an undervalued antimalarial drug, chloroquine to find out the proficiency against ROS mediated caspase activation and apoptosis in liver during Plasmodium berghei NK65 infection." | 7.81 | Chitosan conjugated chloroquine: proficient to protect the induction of liver apoptosis during malaria. ( Chattopadhyay, S; Chowdhuri, AR; Das, S; Dash, SK; Majumdar, S; Roy, S; Sahu, SK; Tripathy, S, 2015) |
| " The compounds were evaluated for their in vivo antimalarial activity against Plasmodium berghei infected mice and the most active derivatives were further examined for their in vitro antimalarial activity against chloroquine resistant (RKL9) strain of Plasmodium falciparum." | 7.81 | New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. ( Abd El Razik, HA; Bekhit, AA; Bekhit, Ael-D; El-Agroudy, EJ; El-Miligy, MM; Hassan, AM, 2015) |
| "Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria." | 7.81 | Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria. ( Bijker, EM; Cockburn, I; Nganou-Makamdop, K; Sauerwein, RW; van Gemert, GJ; Zavala, F, 2015) |
| "In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line treatment of Plasmodium falciparum infections has typically led to the restoration of CQ susceptibility through the reexpansion of the wild-type (WT) allele K76 of the chloroquine resistance transporter gene (pfcrt) at the expense of less fit mutant alleles carrying the CQ resistance (CQR) marker K76T." | 7.81 | Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt. ( Casteras, J; Dhingra, SK; Fidock, DA; Gabryszewski, SJ; Legrand, E; Moss, EL; Musset, L; Neafsey, DE; Pelleau, S; Volkman, SK; Volney, B; Wirth, DF, 2015) |
| "The antimalarial activity and lipid profiles of Methyl Jasmonate (MJ) were investigated against established malaria infection in vivo using BALB/c mice." | 7.81 | Potential antimalarial activity of Methyl Jasmonate and its effect on lipid profiles in Plasmodium Berghei infected mice. ( Ademowo, OG; Emikpe, B; Falade, CO; Kosoko, AM; Oyinloye, OE, 2015) |
| "Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria." | 7.80 | Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria. ( du Plessis, LH; Helena, C; Kotzé, AF; van Huysteen, E; Wiesner, L, 2014) |
| "Plumbagin exhibited promising antimalarial activity with in vitro IC50 (concentration that inhibits parasite growth to 50%) against 3D7 chloroquine-sensitive P." | 7.80 | Antimalarial activity of plumbagin in vitro and in animal models. ( Chaijaroenkul, W; Karbwang, J; Na-Bangchang, K; Plengsuriyakarn, T; Sumsakul, W; Viyanant, V, 2014) |
| "To investigate the antimalarial potential of kolaviron (KV), a biflavonoid fraction from Garcinia kola seeds, against Plasmodium berghei (P." | 7.80 | Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice. ( Aderemi, K; Ayokulehin, K; Catherine, F; Olusegun, A; Oluwatosin, A; Patricia, O; Tolulope, A, 2014) |
| "An alternative antimalarial pathway of an 'outdated' drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials." | 7.80 | Validation of a chloroquine-induced cell death mechanism for clinical use against malaria. ( Batty, KT; Ch'ng, JH; Chang, ZW; Chia, WN; Gun, SY; Lee, YQ; Nosten, F; Renia, L; Russell, B; Tan, KS; Wong, LK, 2014) |
| "Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported." | 7.80 | Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat province, Western Cambodia. ( Amaratunga, C; Anderson, JM; Chuor, CM; Fairhurst, RM; Mao, S; Sreng, S; Suon, S; Tullo, GS, 2014) |
| "Results indicate prominent anti-malarial action of tigecycline in vitro and in vivo in combination with CQ and support further evaluation of tigecycline as a potential combination candidate for treatment of drug-resistant cases of malaria." | 7.80 | In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine. ( Sahu, R; Tekwani, BL; Walker, LA, 2014) |
| "To obtain a high antimalarial activity with neocryptolepine derivatives, modifying and changing the side chains at the C11 position with varying the substituents of an electron-withdrawing or electron-donating nature at the C2 position for a SAR study were executed." | 7.79 | Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines. ( El Sayed, I; Inokuchi, T; Kaiser, M; Lu, WJ; Maeda, T; Mei, ZW; Pang, CQ; Peng, W; Wang, L, 2013) |
| "Due to the widespread prevalence of resistant parasites, chloroquine (CQ) was removed from front-line antimalarial chemotherapy in the 1990s despite its initial promise of disease eradication." | 7.79 | A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. ( Boudhar, A; Bozdech, Z; Ch'ng, JH; Lear, MJ; Mok, S; Nosten, F; Russell, B; Tan, KS, 2013) |
| "Previously reported studies identified analogues of propafenone that had potent antimalarial activity, reduced cardiac ion channel activity, and properties that suggested the potential for clinical development for malaria." | 7.78 | Lead optimization of antimalarial propafenone analogues. ( Clark, JA; Connelly, MC; Derisi, JL; Furimsky, A; Gow, J; Guiguemde, WA; Guy, RK; Iyer, LV; Kyle, DE; Lemoff, A; Lowes, D; Mirsalis, J; Parman, T; Pradhan, A; Sigal, M; Tang, L; Wilson, E; Zhu, F, 2012) |
| "Chloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or therapeutic index)." | 7.78 | Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites. ( Aguiar, AC; Cortopassi, WA; Figueiredo, FJ; França, TC; Krettli, AU; Meneghetti, MR; Pimentel, AS; Santos, Rde M, 2012) |
| "The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei." | 7.78 | The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. ( Aldana, I; Bertani, S; Deharo, E; Garavito, G; Quiliano, M; Valentin, A, 2012) |
| "Reports of potential drug-resistant strains of Plasmodium malariae in western Indonesia raise concerns that chloroquine resistance may be emerging in P." | 7.77 | In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. ( Anstey, NM; Chalfein, F; Ebsworth, EP; Kenangalem, E; Marfurt, J; Piera, KA; Prasetyorini, B; Price, RN; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, M, 2011) |
| "An ethnopharmacological investigation was undertaken on Western Ghats plants traditionally used to treat malaria; 50 plants were very carefully selected from total of 372 plants, and 216 extracts were prepared and tested for in vivo antiplasmodial activity alone and in combination with chloroquine (CQ) against CQ-tolerant Plasmodium berghei (strain NK65)." | 7.77 | Antimalarial activity of traditionally used Western Ghats plants from India and their interactions with chloroquine against chloroquine-tolerant Plasmodium berghei. ( Kadarkari, M; Samy, K, 2011) |
| "The local atomic structure around the central iron of the synthetic soluble analog of malarial pigment in acetic acid solution and with addition of chloroquine as found by X-ray absorption spectroscopy is reported." | 7.77 | Toward understanding the chloroquine action at the molecular level in antimalarial therapy--X-ray absorption studies in acetic acid solution. ( Bellemare, MJ; Bohle, DS; Kosar, AJ; Lawniczak-Jablonska, K; Sienkiewicz, A; Sikora, M; Suárez, L; Walczak, MS; Wolska, A, 2011) |
| "Chloroquine (CQ) is an important antimalarial drug for the treatment of special patient groups and as a comparator for preclinical testing of new drugs." | 7.77 | Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model. ( Batty, KT; Ilett, KF; Jago, JD; Moore, BR; Page-Sharp, M; Stoney, JR, 2011) |
| "Chloroquine-proguanil association is recommended for prophylaxis against falciparum malaria in countries with a low prevalence of chloroquine resistance." | 7.76 | [Duodenal ulcers caused by chloroquine-proguanil association]. ( Imbert, P; Méchaï, F; Rapp, C; Rivière, F; Roux, X, 2010) |
| "Synthesis of new 6-ureido-4-anilinoquinazolines have been accomplished and their in vitro antimalarial activity against chloroquine-sensitive P." | 7.75 | Search for new pharmacophores for antimalarial activity. Part II: synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines. ( Batra, S; Madapa, S; Mishra, A; Pandey, SK; Puri, SK; Srivastava, K; Tripathi, R; Tusi, Z, 2009) |
| "In an attempt to augment the efficacy of 7-chloro 4-aminoquinoline analogs and also to overcome resistance to antimalarial agents, we synthesized three cyclen (1,4,7,10-tetraazacyclododecane) analogs of chloroquine [a bisquinoline derivative, 7-chloro-4-(1,4,7,10-tetraaza-cyclododec-1-yl)-quinoline HBr, and a 7-chloro-4-(1,4,7,10-tetraaza-cyclododec-1-yl)-quinoline-Zn(2+) complex]." | 7.75 | Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs. ( Borne, RF; Khan, MO; Khan, SI; Kimura, E; Levi, MS; Tekwani, BL, 2009) |
| "We retrospectively assessed the impact of chloroquine (CQ) resistance in the rural region of Niakhar, Senegal, where resistance to CQ emerged in 1992, from increases in consultations and returns of patients to the health centre following antimalarial treatment." | 7.75 | Absence of an impact of resistance to chloroquine on consultations for malaria in Niakhar, Senegal (1992-2004). ( Chippaux, JP; Diallo, A; Munier, A, 2009) |
| "Antiretroviral protease inhibitors significantly potentiated the sensitivity of chloroquine-resistant malaria parasites to the antimalarial drug in vitro and in vivo." | 7.75 | Antiretroviral protease inhibitors potentiate chloroquine antimalarial activity in malaria parasites by regulating intracellular glutathione metabolism. ( Chen, L; Chen, X; He, Z; Qin, L; You, J, 2009) |
| " We describe a patient with recurrent malaria, prophylactically treated with low-dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction." | 7.75 | Cardiotoxicity after low-dose chloroquine antimalarial therapy. ( Baratto, F; Doglioni, C; Fragasso, G; Margonato, A; Martinenghi, S; Sanvito, F, 2009) |
| "Recently, it has been assumed that resistance of Plasmodium to chloroquine increased malaria mortality." | 7.75 | Evolution of malaria mortality and morbidity after the emergence of chloroquine resistance in Niakhar, Senegal. ( Arduin, P; Chippaux, JP; Cot, M; Diallo, A; Gning, B; Marra, A; Mboup, BM; Munier, A; Ndiaye, O, 2009) |
| "Amodiaquine (AQ) and tebuquine are 4-aminoquinoline antimalarials with Mannich base side chain and are highly effective against chloroquine (CQ)-resistant strains of Plasmodium falciparum." | 7.74 | Synthesis and antimalarial activity of new isotebuquine analogues. ( Gerena, L; Hudson, TH; Kyle, DE; Lin, AJ; Miroshnikova, OV, 2007) |
| "The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo." | 7.74 | Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1). ( Milhous, WK; Milić, D; Opsenica, D; Smith, KS; Solaja, BA; Terzić, N; Tinant, B, 2007) |
| "In West Africa, treatment for the prevention of malaria during pregnancy has recently changed from chloroquine (CQ) prophylaxis to intermittent preventive treatment (IPTp)." | 7.74 | Efficacy of intermittent preventive treatment versus chloroquine prophylaxis to prevent malaria during pregnancy in Benin. ( Briand, V; Cot, M; Denoeud, L; Massougbodji, A, 2008) |
| "The emergence and spread of Plasmodium falciparum with resistance to chloroquine (CQ), the safest and cheapest antimalarial drug coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the need to optimize antimalarial actions of plant extracts and restore chloroquine efficacy." | 7.74 | Enhanced antimalarial effects of chloroquine by aqueous Vernonia amygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasmodium berghei strains. ( Iwalokun, BA, 2008) |
| "Methanolic extracts from 15 medicinal plants representing 11 families, used traditionally for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ)-tolerant Plasmodium berghei NK65, either alone or in combination with CQ." | 7.74 | Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice. ( Amano, T; Ishih, A; Kino, H; Miyase, T; Mkoji, GM; Muregi, FW; Suzuki, T; Terada, M, 2007) |
| "Hot water extracts from eight medicinal plants representing five families, used for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ) resistant Plasmodium berghei NK65, either alone or in combination with CQ." | 7.74 | In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice. ( Amano, T; Ishih, A; Kino, H; Miyase, T; Mkoji, GM; Muregi, FW; Suzuki, T; Terada, M, 2007) |
| "Having reliable forecasts is critical now for producers, malaria-endemic countries and agencies in order to adapt production and procurement of the artemisinin-based combination treatments (ACTs), the new first-line treatments of malaria." | 7.74 | Estimating antimalarial drugs consumption in Africa before the switch to artemisinin-based combination therapies (ACTs). ( D'Altilia, JP; Kindermans, JM; Olliaro, P; Vandenbergh, D; Vreeke, E, 2007) |
| " Anti-malaria drug policy (2007) of the NVBDC recommends chloroquine (CQ) as the first line of drug for the treatment of all malarias." | 7.74 | Battling the malaria iceberg with chloroquine in India. ( Sharma, VP, 2007) |
| "The antimalarial activity of chloroquine-pyrazole analogues, synthesized from the reaction of 1,1,1-trifluoro-4-methoxy-3-alken-2-ones with 4-hydrazino-7-chloroquinoline, has been evaluated in vitro against a chloroquine resistant Plasmodium falciparum clone." | 7.73 | Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues. ( Bonacorso, HG; Cechinel, CA; Cunico, W; de Souza, MV; Freitas, IO; Krettli, AU; Martins, MA; Soares, RP; Zanatta, N, 2006) |
| "Using easily accessible keto-trioxanes 7a-g as the starting materials, a series of new variously functionalized 1,2,4-trioxanes 10-36 have been prepared and evaluated for antimalarial activity against multi-drug-resistant Plasmodium yoelii nigeriensis in mice in the dose range of 24 mg/kg x 4 days to 96 mg/kg x 4 days by oral route." | 7.73 | Orally active 1,2,4-trioxanes: synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant plasmodium yoelii nigeriensis in mice. ( Malik, H; Puri, SK; Singh, C, 2006) |
| "Febrifugine (1), a quinazoline alkaloid, isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum." | 7.73 | Exploration of a new type of antimalarial compounds based on febrifugine. ( Hariguchi, N; Hirai, S; Horoiwa, S; Kasahara, R; Kikuchi, H; Matsumoto, M; Oshima, Y; Yamamoto, K, 2006) |
| "Amodiaquine (AQ) (2) is a 4-aminoquinoline antimalarial that can cause adverse side effects including agranulocytosis and liver damage." | 7.72 | Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials. ( Bickley, JF; Bray, PG; Hindley, S; Hughes, RH; Maggs, JL; Mukhtar, A; O'Neil, IA; O'Neill, PM; Park, BK; Randle, LE; Stocks, PA; Storr, RC; Ward, SA; Winstanley, PA, 2003) |
| "To eliminate an unwarranted metabolic pathway of the quinoline ring, a set of two compounds, where C-2 position of the antimalarial drug primaquine is blocked by metabolically stable bulky alkyl group are synthesized." | 7.72 | Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity. ( Jain, M; Jain, R; Jena, GB; Kaul, CL; Ramarao, P; Sachdeva, S; Singh, PP; Singh, S; Tikoo, K; Vangapandu, S, 2004) |
| "The antimalarial activity of benzo[a]phenazines synthesized from 1,2-naphthoquinone, lapachol, beta-lapachone and several derivatives have been tested against Plasmodium falciparum in vitro using isolates of parasites with various susceptibilities to chloroquine and/or mefloquine." | 7.72 | Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. ( Carvalho, LH; da Silva Filho, JF; da Silva, MJ; de Andrade-Neto, VF; Goulart, MO; Krettli, AU; Pinto, AV; Pinto, Mdo C; Zalis, MG, 2004) |
| "To study the relationship between neutral aminopeptidase activity and hemoglobin accumulation in malaria parasites, we treated mice infected with Plasmodium berghei NYU-2 with chloroquine intraperitoneally in doses ranging from 0." | 7.72 | Relationship of chloroquine-induced redistribution of a neutral aminopeptidase to hemoglobin accumulation in malaria parasites. ( Cai, GZ; Chen, YF; Fitch, CD; Ryerse, JS, 2003) |
| "To study the antimalarial effect of agmatine (Agm) on chloroquine-susceptible Plasmodium berghei K173 strain (S strain) and the P berghei K173 resistant strain (R strain)." | 7.72 | Antimalarial effect of agmatine on Plasmodium berghei K173 strain. ( Li, J; Liu, Y; Su, RB; Wei, XL, 2003) |
| " A major determinant of compliance with treatment in this environment is the pruritus chloroquine induces when ingested." | 7.72 | Pattern of chloroquine-induced pruritus in antenatal patients at the University College Hospital, Ibadan. ( Adeniji, AR; Aimakhu, CO; Fehintola, FA; Olayemi, O; Osungbade, A; Udoh, ES, 2003) |
| "Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance." | 7.72 | The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. ( , 2003) |
| "Chloroquine and related anti-malarial drugs appear to promote apoptosis in T-cells by suppressing NF-kappa-B, which enhances the expression of anti-apoptotic proteins (e." | 7.72 | Hypothesis links emergence of chloroquine-resistant malaria and other intracellular pathogens and suggests a new strategy for treatment of diseases caused by intracellular parasites. ( Parris, GE, 2004) |
| "To document successful community chloroquine distribution for malaria control in Bushenyi district, southwestern Uganda." | 7.72 | Community chloroquine distribution for malaria control in Bushenyi district of Uganda. ( Nuwaha, F; Okware, J; Timbyetaho, HN, 2003) |
| "The role of haem iron (II) and oxidative stress in the activation and antimalarial activity of artemisinin is unclear." | 7.72 | Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin. ( Basilico, N; Mondani, M; Monti, D; Olliaro, P; Parapini, S; Taramelli, D, 2004) |
| " The physiological hormone dehydroepiandrosterone sulfate (DHEAS) is a potent inhibitor of G6PD activity, and G6PD deficiency is known to exert antimalaria protection." | 7.72 | Plasmodium berghei: dehydroepiandrosterone sulfate reverses chloroquino-resistance in experimental malaria infection; correlation with glucose 6-phosphate dehydrogenase and glutathione synthesis pathway. ( Haumont, G; Malvy, D; Mangou, F; Millet, P; Mossalayi, D; Olliaro, P; Safeukui, I; Vatan, R; Vincendeau, P, 2004) |
| "This study was carried out in the village of Faladié, Mali located in the malaria-endemic Kati region, two years after routine use of chloroquine prophylaxis was discontinued in children 0 to 9 years old." | 7.72 | [Assessment of chloroquine resistance two years after stopping chemoprophylaxis in 0 to 9-year-old children living in a malaria-endemic village of Mali]. ( Diallo, M; Diawara, A; Doumbo, O; Sacko, M; Sangho, H; Sango, HA; Sow, S, 2004) |
| "The potent antimalarial activity of chloroquine against chloroquine-sensitive strains can be attributed, in part, to its high accumulation in the acidic environment of the heme-rich parasite food vacuole." | 7.71 | Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues. ( Bray, PG; Davies, J; Hindley, S; O'Neill, PM; Park, BK; Searle, NL; Storr, RC; Ward, SA, 2002) |
| "Although febrifugine (1) and isofebrifugine (2), alkaloids isolated from roots of the Dichroa febrifuga plant, show powerful antimalarial activity against Plasmodium falciparum, strong side effects such as the emetic effect have precluded their clinical use against malaria." | 7.71 | Potent antimalarial febrifugine analogues against the plasmodium malaria parasite. ( Hatakeyama, S; Hirai, S; Iwabuchi, Y; Kikuchi, H; Kim, HS; Ooi, H; Oshima, Y; Takaya, Y; Tasaka, H; Wataya, Y, 2002) |
| "Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro." | 7.71 | Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine. ( Biswas, S; Dua, VK; Puri, SK; Sharma, VP; Sinha, SN; Valecha, N, 2002) |
| "A retrospective examination was made of archival data on the response of Plasmodium malariae infections in humans to chloroquine." | 7.71 | Extended clearance time after treatment of infections with Plasmodium malariae may not be indicative of resistance to chloroquine. ( Collins, WE; Jeffery, GM, 2002) |
| "The hypothesis that chloroquine-induced pruritus (CIP) may be determined by certain genetic factors was tested by investigating the epidemiology of CIP with respect to certain genetic red cell markers namely, haemoglobin genotype, glucose-6-phosphate dehydrogenase (G6PD) deficiency and the ABO blood groups." | 7.71 | Certain red cell genetic factors and prevalence of chloroquine-induced pruritus. ( Ademowo, OG; Sodeinde, O, 2002) |
| "In the fight against malaria, chemotherapy using bisacridines may represent an alternative method to overcoming chloroquine-resistance." | 7.71 | Antimalarial in-vivo activity of bis(9-amino-6-chloro-2-methoxyacridines). ( Berecibar, A; Debreu-Fontaine, MA; Delarue, S; Girault, S; Grellier, P; Lemiere, P; Maes, L; Quirijnen, L; Sergheraert, C, 2001) |
| "Chloroquine retinopathy (CR) is a major complication of long-term malaria prophylaxis (LTMP) causing permanent visual dysfunction and occasionally blindness." | 7.71 | Case report: Retinopathy after malaria prophylaxis with chloroquine. ( Bertagnolio, S; Camilli, G; Tacconelli, E; Tumbarello, M, 2001) |
| "Prior to policy change from chloroquine (CQ) to sulphadoxine/pyrimethamine (S/P; Fansidar) we assessed the perception of CQ efficacy and the alternative treatment options for malaria in children among parents/guardians (N=527) of under-fives attending first level health facilities on account of fever." | 7.71 | Perception of chloroquine efficacy and alternative treatments for uncomplicated malaria in children in a holoendemic area of Tanzania: implications for the change of treatment policy. ( Bygbjerg, IC; Minjas, JN; Tarimo, DS, 2001) |
| "Study of children treated for uncomplicated malaria in the sub-prefecture of Zouan Hounien in Western Côte d'Ivoire demonstrated that clinical failure rates (WHO 14-day test) were 43% for chloroquine and 6% for pyrimethamine-sulfadoxine (PS)." | 7.71 | [Which medication should be used to treat uncomplicated malaria when chloroquine becomes ineffective in Western Côte d'Ivoire?]. ( Henry, MC; Kone, M; Niangue, J, 2002) |
| "Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy." | 7.70 | Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy. ( Edwards, R; Fuchs, E; Kerr, L; Phillips-Howard, PA; Schildknecht, J; Steffen, R; Vanhauwere, B, 1998) |
| "Oxygenated chalcones (3a,b) and bischalcones (4a-j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice." | 7.70 | Oxygenated chalcones and bischalcones as potential antimalarial agents. ( Chandra, S; Ram, VJ; Saxena, AS; Srivastava, S, 2000) |
| "Several compounds in current clinical use as antihistaminic agents, among them cyproheptadine (CYP), have been shown, in experimental models, to reverse resistance of the asexual, intra-erythrocytic stages of rodent or human malarial parasites to chloroquine (CQ)." | 7.70 | The chemotherapy of rodent malaria. LIX. Drug combinations to impede the selection of drug resistance, Part 3: Observations on cyproheptadine, an antihistaminic agent, with chloroquine. ( Butcher, GA; Peters, W; Robinson, BL; Stewart, LB, 2000) |
| "The antimalarial activities of ferrocenic compounds mimicking chloroquine and active upon chloroquine-resistant strains of Plasmodium falciparum were evaluated." | 7.69 | Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue. ( Biot, C; Brocard, JS; Glorian, G; Maciejewski, LA, 1997) |
| " He used chloroquine as a malaria prophylaxis during his stay and for 6 weeks after his return to Japan." | 7.69 | [A case of Plasmodium ovale malaria with thrombocytopenia and an abnormality grade in FDP concentration despite the use of chloroquine as a malaria prophylaxis]. ( Karino, T; Miyashita, N; Nagatomo, Y; Nakajima, M; Niki, Y; Okimoto, N; Soejima, R; Yoshida, K, 1995) |
| "Chloroquine continues to have a limited role in the chemoprophylaxis against malaria." | 7.69 | No evidence for chloroquine-associated retinopathy among missionaries on long-term malaria chemoprophylaxis. ( Contoreggi, CS; Frame, JD; Frankenfield, DL; Lange, WR; Moriarty-Sheehan, M, 1994) |
| "Ajoene (4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a product initially isolated from extracts of garlic (Allium sativum), was tested for its antimalarial activity in vivo in a well-characterized murine model." | 7.69 | In vivo activity of ajoene against rodent malaria. ( Apitz, R; De la Rosa, M; Perez, HA, 1994) |
| "A severe flare-up of chronic hepatitis B infection with liver cell insufficiency has been observed in two patients after discontinuation of chloroquine administered either as malaria prophylaxis or as treatment of presumed rheumatoid arthritis." | 7.69 | [Reactivation of hepatitis B following withdrawal of chloroquine]. ( Helbling, B; Reichen, J, 1994) |
| "To compare the frequency of adverse events, particularly neuropsychiatric effects, from mefloquine and from chloroquine plus proguanil as used for malaria chemoprophylaxis." | 7.69 | Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers. ( Barrett, PJ; Bradley, DJ; Clarke, PD; Emmins, PD, 1996) |
| "Chloroquine is widely used in malaria chemotherapy." | 7.69 | Carboxylic ionophores in malaria chemotherapy: the effects of monensin and nigericin on Plasmodium falciparum in vitro and Plasmodium vinckei petteri in vivo. ( Adovelande, J; Schrével, J, 1996) |
| "In this study we describe the application of a bioassay for measuring chloroquine equivalent concentrations in plasma samples obtained from soldiers on chloroquine (300 mg weekly) and doxycycline (50 or 100 mg daily) for malaria prophylaxis." | 7.69 | Chloroquine bioassay of plasma specimens obtained from soldiers on chloroquine plus doxycycline for malaria prophylaxis. ( Edstein, MD; Kotecka, BM; Rieckmann, KH, 1996) |
| "Fenozan B07, a 1,2,4-trioxane endoperoxide with potent blood schizontocidal activity against drug-sensitive and drug-resistant rodent malaria parasites, exerted a modest potentiating action when administered with chloroquine (CQ) to mice infected with parasites of the CQ-resistant P." | 7.69 | The chemotherapy of rodent malaria. LIV. Combinations of 'Fenozan B07' (Fenozan-50F), a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane, with other drugs against drug-sensitive and drug-resistant parasites. ( Fleck, SL; Peters, W; Robinson, BL, 1997) |
| " Two subgroups used malaria prophylaxis (mefloquine or proguanil/proguanil-chloroquine): the control group used no prophylaxis." | 7.69 | [Not more symptoms with mefloquine use than with other drugs in malaria prophylaxis]. ( Bosje, T; Luinstra-Passchier, MJ; Wolters, BA, 1997) |
| "Routine malaria prophylaxis with chloroquine (CQ) is recommended to pregnant semi-immune women in several countries in Africa." | 7.69 | Chloroquine blood concentrations and malaria prophylaxis in Tanzanian women during the second and third trimesters of pregnancy. ( Aden Abdi, Y; Diwan, VK; Ericsson, O; Gustafsson, LL; Kilewo, C; Massele, AY; Rimoy, G; Tomson, G, 1997) |
| "On the basis of observations that several bisquinolines such as piperaquine possess notable activity against chloroquine-resistant malaria, 13 N,N-bis-(7-chloroquinolin-4-yl)alkanediamines were synthesized and screened against Plasmodium falciparum in vitro and Plasmodium berghei in vivo." | 7.68 | Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. ( Ager, AL; Andersen, SL; Ellis, WY; Gerena, L; Milhous, WK; Vennerstrom, JL, 1992) |
| "Several antibiotics that inhibit protein synthesis on 70S ribosomes, including the macrolide erythromycin, and the azalides azithromycin (ZITHROMAX) and CP-63,956, demonstrated antimalarial activity against two strains of Plasmodium berghei." | 7.68 | Antimalarial activity of azithromycin and erythromycin against Plasmodium berghei. ( Gingras, BA; Jensen, JB, 1993) |
| "The antimalarial activity of beta-artemether and beta-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P." | 7.68 | Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. ( Ager, AL; Canfield, CJ; Heiffer, MH; Klayman, DL; Kyle, DE; Milhous, WK; Rossan, RN; Schuster, BG; Shmuklarsky, MJ; Tang, DB, 1993) |
| "An oligomeric ester of prostaglandin B2 (OC-5186) was found to reverse chloroquine resistance in the murine malarial parasite Plasmodium berghei." | 7.68 | Reversal of chloroquine resistance in murine malaria parasites by prostaglandin derivatives. ( Chandra, S; Dhawan, BN; Ohnishi, ST, 1993) |
| "A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice." | 7.68 | Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine. ( Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Rudolph, R, 1992) |
| "To confirm reports that chloroquine-induced pruritus might have a negative impact on chloroquine utilization on malaria control in Dar es Salaam, a precoded questionnaire was administered to 300 malaria patients and the respondents were then followed up at their homes during the period of their malaria treatment." | 7.68 | Chloroquine-induced pruritus: its impact on chloroquine utilization in malaria control in Dar es Salaam. ( Kihamia, CM; Mnyika, KS, 1991) |
| "The antimalarial chloroquine, by virtue of its weak base properties, concentrates in the acidic compartment(s) of the intraerythrocytic parasite." | 7.68 | Kinetic modelling of chloroquine uptake by malaria-infected erythrocytes. Assessment of the factors that may determine drug resistance. ( Ginsburg, H; Stein, WD, 1991) |
| "Although the use of chloroquine (C) and hydroxychloroquine (HC) in the treatment of malaria prophylaxis during pregnancy is probably safe, the use of much higher doses for treatment of systemic lupus erythematosus (SLE) and rheumatoid arthritis during pregnancy has been controversial." | 7.68 | Pregnancy outcome following first trimester exposure to chloroquine. ( Buskila, D; Gladman, DD; Koren, G; Levy, M; Urowitz, MB, 1991) |
| "Two patients with psoriasis vulgaris who travelled to endemic malaria areas developed erythroderma and generalized psoriasis guttata 3-4 weeks after starting prophylactic antimalarial medication with chloroquine/proguanil." | 7.68 | [Exacerbation of psoriasis caused by malaria prophylaxis with chloroquine and proguanil]. ( Damstra, RJ; van Vloten, WA, 1991) |
| " In the clinical study, 125 patients given intramuscular chloroquine for malaria were followed for 2 months in order to detect local injection site complications." | 7.68 | Acute gluteal abscess following intramuscular chloroquine injection: a clinical and experimental study. ( Ahmed, ME; elHassan, AM; elZaki, K; Fahal, AH; Yousif, MA, 1991) |
| "From 1986 until 1988 chloroquine sensitivity of Plasmodium falciparum malaria was monitored in 515 hospital patients in Nchelenge district, northeastern Zambia." | 7.68 | Chloroquine-resistant Plasmodium falciparum malaria at Nchelenge, northeastern Zambia. Follow-up on 515 hospital patients. ( Gernaat, HB; Verhagen, MA; Woods, SM, 1990) |
| "59 cases of Plasmodium falciparum malaria fever occurring in non-immune Caucasian subjects having got a correct chemoprophylaxis by chloroquine were treated by halofantrine (HALFAN)." | 7.68 | [The treatment of imported Plasmodium falciparum malaria with halofantrine. Apropos of 59 case reports (corrected and republished article orginally printed in Med Trop (Mars) 1990 Jan-Mar;50(1):113-7)]. ( Becker, JM; Bernard, J; Dupasquier, I; Geffray, L; Gimenez, M; Jourdan, G; Lesbordes, JL; Molinas, JM; Sarrouy, J, 1990) |
| "Six hundred and twenty pregnant women, living under conditions of year-round transmission of malaria in a rural coastal area of Madang, Papua New Guinea (PNG), were followed while attending mobile antenatal clinics and receiving chloroquine prophylaxis (300 mg base weekly)." | 7.68 | Failure of chloroquine prophylaxis for falciparum malaria in pregnant women in Madang, Papua New Guinea. ( Alpers, M; Brabin, BJ; Brabin, L; Eggelte, T; Ginny, M; Van der Kaay, HJ, 1990) |
| "The good results achieved in the treatment of malaria with a 7 and 5 days one of quinine (orally dose 8 mg/kg/8 h), incited the authors to try a 3 days long treatment at the same dose." | 7.68 | [Uncomplicated attack of malaria in an area with high resistance to chloroquine. I. Evaluation of a short treatment with quinine]. ( Abissegue, B; Farinotti, R; Gelas, H; Ghipponi, PM; Hengy, C; Jambou, R; Le Bras, J, 1990) |
| "The authors evaluate the comparative efficiency of chloroquine and amodiaquine (35 mg/kg during 3 days) for uncomplicated malaria treatment in an area with high chemoresistance level." | 7.68 | [Uncomplicated malaria attack in an area with high chloroquine resistance. 2. Evaluation of first-choice therapeutic scheme]. ( Arrive, A; Eberlé, F; Gazin, P; Hengy, C; Jambou, R; Kouka-Bemba, D, 1990) |
| "In October and November 1988 we carried out in vivo Plasmodium falciparum sensitivity tests for chloroquine in the town of Dakar, where malaria is endemic with increased transmission during the rainy season (July to October)." | 7.68 | [The emergence of chloroquine-resistant malaria in Dakar, Senegal]. ( Bah, IB; Bengua, E; Diallo, S; Faye, O; Gaye, O; Victorius, A, 1990) |
| "In Eastern Thailand the increasing resistance of Plasmodium falciparum to all available antimalarial drugs prompted a reassessment of chloroquine in combination with either erythromycin or tetracycline." | 7.67 | Failure of chloroquine-erythromycin and chloroquine-tetracycline combinations in treatment of chloroquine-resistant falciparum malaria in eastern Thailand. ( Karbwang, J; Kasemsarn, P; Looareesuwan, S; Phillips, RE; Warhurst, DC; Warrell, DA; White, NJ, 1984) |
| "A determination of the sensitivity to chloroquine and to mefloquine was carried out in malaria patients of the Albert Schweitzer Hospital, Lambarene, Gabon, by using the schizont maturation test." | 7.67 | Plasmodium falciparum-malaria: resistance to chloroquine, but sensitivity to mefloquine in the Gabon. A prospective in-vitro study. ( Burchard, GD; Dietrich, M; Horstmann, RD; Wernsdorfer, WH, 1984) |
| "Mössbauer studies of rat erythrocytes infected by Plasmodium berghei malaria parasites, using 57Fe-enriched rat red blood cells, were carried out in order to determine the physical parameters which characterize the malarial pigment iron and to test the effect of the widely used antimalaria drug, chloroquine, on these parameters." | 7.67 | The malarial pigment in rat infected erythrocytes and its interaction with chloroquine. A Mössbauer effect study. ( Bauminger, ER; Ginsburg, H; Ofer, S; Yayon, A, 1984) |
| "A 16-year old girl with insulin-dependent diabetes mellitus (8 years' duration) developed tropic malaria 7 weeks after her return from Kenya despite a longtime prophylaxis using pyrimethamine and sulfadoxine (Fansidar)." | 7.67 | [Chloroquine and pyrimethamine/sulfadoxine resistant malaria tropica in a child with diabetes mellitus]. ( Bienzle, U; Burger, W; Kroll, MH; Weber, B, 1984) |
| "Chloroquine-resistant Plasmodium falciparum malaria has been described in East, Central and West Africa." | 7.67 | Probable chloroquine-resistant Plasmodium falciparum malaria in south-western Africa. ( Blumenfeld, AM; Davidson, A; Isaäcson, M; Sieling, WL, 1984) |
| "Chloroquine (CQ), the most widely used antimalarial drug, is an acidotropic agent (De Duve, 1983) which accumulates to high levels in malaria-infected erythrocytes." | 7.67 | Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine. ( Cabantchik, ZI; Ginsburg, H; Yayon, A, 1984) |
| "A questionnaire survey was performed among 550 acutely febrile patients with malaria to determine whether pruritus accompanied chloroquine therapy when the drug was employed to suppress paroxysmal febrile attacks." | 7.67 | Chloroquine-induced pruritus among patients with malaria. ( Osifo, NG, 1984) |
| "Chloroquine (Cq) and desethyl-chloroquine ( CqM ) levels were measured by HPLC in the blood, plasma, and erythrocytes of 9 healthy subjects under standard prophylactic treatment (100 mg/day for 10 days) and 8 malarial patients given a therapeutic regimen (10 or 25 mg/kg)." | 7.67 | [Distribution of chloroquine and desethylchloroquine in blood, plasma and erythrocytes of healthy subjects and malaria patients. Assay using HPLC]. ( Blayo, MC; Clavier, F; Deloron, P; Verdier, F, 1984) |
| "Racemic verapamil and close structural derivatives gallopamil and devapamil completely reverse chloroquine-resistance in falciparum malaria at 1-2 micromolar concentrations." | 7.67 | Reversal of chloroquine resistance in falciparum malaria independent of calcium channels. ( Van Dyke, K; Ye, ZG, 1988) |
| "A number of bis(benzyl)polyamine analogs were found to be potent inhibitors of both chloroquine-resistant and chloroquine-sensitive strains of the human malaria parasite Plasmodium falciparum in vitro (IC50 values = 0." | 7.67 | Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria. ( Bitonti, AJ; Bush, TL; Dumont, JA; Edwards, ML; McCann, PP; Sjoerdsma, A; Stemerick, DM, 1989) |
| "A 39-year-old Japanese male engineer who stayed in Nigeria from August 17, 1987 through January 22, 1988, presented chloroquine-resistant Plasmodium falciparum malaria." | 7.67 | [Chloroquine-resistant Plasmodium falciparum malaria confirmed by semi-micro sensitivity test for chloroquine seen in a person returned from Nigeria to Japan]. ( Kano, S; Matsuoka, Y; Obana, M; Suzuki, M; Waki, S; Yamakawa, H, 1989) |
| "To develop a malaria treatment policy for children with Plasmodium falciparum, an in vivo and in vitro chloroquine (CQ) sensitivity study was conducted in Côte d'Ivoire in September 1986." | 7.67 | Formulation of malaria treatment policy for children in Côte d'Ivoire as chloroquine resistant Plasmodium falciparum spreads into west Africa. ( Breman, JG; Davis, CE; Nguyen-Dinh, P; Peyron, FM; Saki, ZM; Soro, B; Yao, F, 1989) |
| "The use of Méfloquine in the prophylactic treatment of malaria has, up to now, been hampered by the standpoint adopted by the WHO, the Conseil Supérieur d'Hygiène and some specialists, for whom Méfloquine should be administered only for short stays in areas of strong chloroquine-resistance." | 7.67 | [The role of mefloquine in the prevention of malaria]. ( Lapierre, J; Périn, M; Sureau, C, 1989) |
| "In this study, the advantage of the use of chloroquine (CQ) containing liposomes (lipCQ) over free CQ in the chemotherapy of murine malaria (Plasmodium berghei) was demonstrated." | 7.67 | Chloroquine containing liposomes in the chemotherapy of murine malaria. ( Crommelin, DJ; Eling, WM; Huiskamp, CW; Peeters, PA, 1989) |
| "Feeding a vitamin E-deficient diet containing 5% menhaden oil to mice affords significant protection against both a chloroquine-sensitive and a chloroquine-resistant line of the malarial parasite." | 7.67 | Menhaden-fish oil in a vitamin E-deficient diet: protection against chloroquine-resistant malaria in mice. ( Ager, AL; Levander, OA; May, RG; Morris, VC, 1989) |
| "The Nigerian Federal Ministry of Health in 1987 instituted a nationwide programme to gather data on the efficacy of chloroquine in treating malaria in children as a basis for the development of a national malaria therapy policy." | 7.67 | Efficacy of chloroquine in the treatment of malaria in children under five years in Baissa (Gongola State, Nigeria). ( Daniel, HI; Molta, NB, 1989) |
| " No malaria attack was observed in the group (n = 32) taking chlorproguanil and chloroquine for chemoprophylaxis." | 7.67 | [A study of the efficacy of the chemoprevention of malaria using chlorproguanil alone or in combination with chloroquine in French expatriates in Dar-es-Salaam, Tanzania]. ( Flachs, H; Havermann, K; Le Bras, J; Ringwald, P, 1989) |
| "In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h." | 7.67 | Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. ( Attanath, P; Benjasurat, Y; Karbwang, J; Looareesuwan, S; Phillips, RE; Warrell, DA; White, NJ, 1985) |
| "Standard triple-dose therapy with chloroquine (25 mg base/kg) failed to clear asexual Plasmodium falciparum parasites from the blood of 22 of 98 patients infected in various parts of Ethiopia and evaluated in Addis Ababa, a malaria-free city." | 7.67 | Chloroquine-resistant Plasmodium falciparum malaria in Ethiopia. ( Teklehaimanot, A, 1986) |
| "Two hundred and fifty-one Nigerian medical and nursing students from the University of Maiduguri Teaching Hospital completed a questionnaire on chloroquine-induced pruritus." | 7.67 | Chloroquine-induced pruritus in Nigerian medical and nursing students. ( Chugh, KS; Harries, AD, 1986) |
| " Thirty-four patients with falciparum malaria were screened for in-vitro resistance to chloroquine, mefloquine and quinine using the WHO standard micro-test." | 7.67 | Response of Kampuchean strains of Plasmodium falciparum to antimalarials: in-vivo assessment of quinine and quinine plus tetracycline; multiple drug resistance in vitro. ( Denis, MB; Giboda, M, 1988) |
| "Within the framework of its surveillance of Plasmodium falciparum chloroquine sensitivity in eight West African countries (Benin, Burkina Faso, Côte d'lvoire, Mali, Mauritany, Niger, Senegal, and Togo) the Reference Centre for Chemoresistant Malaria (CRCP) at the Organization for Coordination and Cooperation to Control Major Endemic Diseases (O." | 7.67 | [Emergence of chloroquine-resistant malaria in West Africa: the case of Sokode (Togo)]. ( Gbary, AR; Guiguemdé, TR; Ouedraogo, JB, 1988) |
| "Oral mepacrine dihydrochloride, 200 mg (158 mg of the base) six-hourly for five doses followed by 100 mg (79 mg of the base) eight-hourly for six days (half dosage for those less than or equal to 50 kg) was given to 21 patients with high-grade chloroquine-resistant falciparum malaria in eastern Thailand." | 7.67 | Mepacrine accumulation during treatment of chloroquine-resistant falciparum malaria. ( Chanthavanich, P; Edwards, G; Looareesuwan, S; Phillips, RE; Rodick, CL; Supanaranond, W; Warrell, DA, 1988) |
| "Although empirical regimens of parenteral chloroquine have been used extensively to treat severe malaria for 40 years, recent recommendations state that parenteral chloroquine should no longer be used because of potential toxicity." | 7.67 | Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations. ( Berry, C; Brown, J; Churchill, FC; Greenwood, BM; Miller, KD; White, NJ; Williams, SB, 1988) |
| "Proguanil 200mg daily and chloroquine base 300mg weekly along with maloprim 1 tablet weekly was used as malaria chemoprophylaxis for 140 Hong Kong based soliders on a seven-week jungle exercise in a holoendemic malarial area of Papua New Guinea." | 7.67 | Malaria chemoprophylaxis with a proguanil-chloroquine-maloprim combination in Papua New Guinea. ( Heap, BJ, 1988) |
| "In vivo sensitivity of Plasmodium falciparum to chloroquine was evaluated in 4 of 9 regions of Zaire in 1985 to develop a national strategy for treatment of malaria." | 7.67 | Response of children with Plasmodium falciparum to chloroquine and development of a national malaria treatment policy in Zaire. ( Breman, JG; ma-Disu, M; Moore, M; Ngimbi, NP; Paluku, KM; Roy, J; Sexton, JD; Steketee, RW; Weinman, JM, 1988) |
| "The drug of choice in the treatment of chloroquine-resistant Plasmodium falciparum malaria is parenteral quinine dihydrochloride." | 7.67 | Ineffectiveness of continuous quinidine gluconate infusion in the treatment of severe chloroquine-resistant Plasmodium falciparum malaria. ( Chan, LA; Matsuura, GK, 1988) |
| "Representatives of 200 urban and 200 rural households were interviewed to determine the extent and appropriateness of the use of chloroquine obtained over-the-counter for malaria prophylaxis." | 7.67 | Self-medication with chloroquine for malaria prophylaxis in urban and rural Zimbabweans. ( Gora, NP; Macheka, BM; Stein, CM, 1988) |
| "Using [G-3H]hypoxanthine uptake as a radioactive indicator for the growth of malarial parasites, we measured the antimalarial activity of artemisinin (Qinghaosu, QHS) against FCMSU1/Sudan strain (chloroquine-sensitive strain) and FCB K+ strain (chloroquine-resistant strain) of Plasmodium falciparum in continuous culture in vitro." | 7.67 | Effect of artemisinin (qinghaosu) and chloroquine on drug-sensitive and drug-resistant strains of Plasmodium falciparum malaria: use of [2,8-3H]adenosine as an alternative to [G-3H]hypoxanthine in the assessment of in vitro antimalarial activity. ( Van Dyke, K; Wimmer, M; Ye, ZG, 1987) |
| "World areas with chloroquine-resistant falciparum malaria are progressively spreading, in Africa from East to West." | 7.67 | [A case of chloroquine-resistant malaria of type R3 originating in Cameroon]. ( Alvar, J; Barreiros, G; Benito, A; Martin-Fontelos, P; Ortiz, M, 1987) |
| "A case of chloroquine-resistant falciparum malaria imported into Italy from Angola is reported." | 7.67 | [Chloroquine-resistant Plasmodium falciparum malaria imported into Italy]. ( Fossaluzza, V; Rossi, P; Schiavon, I; Tosato, F; Udina, P, 1987) |
| "The concentrations of chloroquine and desethylchloroquine in the blood of 10 healthy adult Swedish volunteers who had been taking 310 mg chloroquine base once a week for at least 8 months for malaria prophylaxis were measured." | 7.67 | Chloroquine and desethylchloroquine concentrations during regular long-term malaria prophylaxis. ( Bergqvist, Y; Hellgren, U; Rombo, L, 1987) |
| "A death from chloroquinoresistant falciparum malaria contracted by a traveller under chloroquine chemoprophylaxis during a stay in the Cameroon provides the authors with an opportunity to analyze the extension of chloroquinoresistance in Africa." | 7.67 | [A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon]. ( Beylot, J; Combe, A; Le Bras, J; Le Bras, M; Raccurt, CP; Ripert, C, 1986) |
| "Six imported cases of chloroquine-resistant Falciparum malaria have been studied since October 1984." | 7.67 | Imported cases of chloroquine-resistant falciparum malaria in Iran. ( Afshar, A; Edrissian, GH; Emadi, AM; Ghorbani, M; Hajseyed-Javadi, J; Khaleghian, B; Pishva, E; Saghari, H; Shahabi, S, 1986) |
| "Chloroquine-resistant Plasmodium falciparum malaria contracted in Mozambique by a patient taking correct prophylaxis is reported." | 7.67 | Chloroquine-resistant malaria. A case report. ( Dini, GC, 1986) |
| "Seven patients (one black African and six white Europeans) developed chloroquine-resistant falciparum malaria in East Africa." | 7.67 | Chloroquine-resistant falciparum malaria from East Africa. ( Bhattacharya, DN; Hall, AP, 1986) |
| "Sixty-eight cases of vivax and 30 cases of falciparum malaria patients were treated with a combination of sulfamonomethoxine-pyrimethamine (MP tablet with 500 mg of sulfamonomethoxine and 25 mg of pyrimethamine) and the results were compared with those with chloroquine, Fansidar and quinine." | 7.67 | A combination of sulfamonomethoxine and pyrimethamine versus other drugs for the treatment of malaria. ( Ebisawa, I; Ohara, H, 1986) |
| "Mefloquine-sulphadoxine-pyrimethamine (MSP) in combination has proved effective against multiple-drug-resistant falciparum malaria, but nothing is known about mefloquine absorption when it is given in this formulation." | 7.67 | Plasma and whole blood mefloquine concentrations during treatment of chloroquine-resistant falciparum malaria with the combination mefloquine-sulphadoxine-pyrimethamine. ( Back, DJ; Karbwang, J; Looareesuwan, S; Molyneux, ME; Nagachinta, B; Phillips, RE; Warrell, DA; Wattanagoon, Y, 1987) |
| "Urinary excretion of chloroquine and its desethyl-metabolite was monitored for up to 395 days after the last dose of oral chloroquine (300 mg base) taken once weekly for 10 weeks as malaria prophylaxis." | 7.67 | Chloroquine excretion following malaria prophylaxis. ( Alván, G; Grahnén, A; Gustafsson, LL; Lindström, B, 1987) |
| "A community-based malaria control programme in Saradidi, Kenya provided chloroquine treatment for malaria in each village beginning in May 1982." | 7.67 | Consumption of chloroquine phosphate provided for treatment of malaria by volunteer village health workers in Saradidi, Kenya. ( Huong, AY; Kaseje, DC; Roberts, JM; Spencer, HC, 1987) |
| "A fatal case of Stevens-Johnson syndrome associated with Fansidar and chloroquine is reported in a 5-year-old boy." | 7.67 | Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine. ( Bamber, MG; Elder, AT; Gray, JA; Minns, RA, 1986) |
| "Administration of chloroquine after major surgery is indicated in malaria endemic areas." | 7.67 | Chloroquine administration for malaria suppression after abdominal surgery. ( Betschart, B; Burnier, E; Mwakilasa, A; Schweizer, W; Stahel, E; Stutz, P; Tanner, M, 1987) |
| "A prospective study of imported chloroquine-resistant falciparum malaria in the Netherlands is described." | 7.67 | Chloroquine-resistant falciparum malaria imported into the Netherlands. ( de Geus, A; Wetsteyn, JC, 1985) |
| "Chloroquine (CQ) accumulates in the acidic food vacuole of intraerythrocytic malaria parasites (Plasmodium falciparum) by virtue of its weak base properties." | 7.67 | Susceptibility of human malaria parasites to chloroquine is pH dependent. ( Cabantchik, ZI; Ginsburg, H; Yayon, A, 1985) |
| "A Venda child with Plasmodium falciparum malaria had a recurrence of illness 3 weeks after an adequate course of chloroquine." | 7.67 | In vivo and in vitro chloroquine-resistant falciparum malaria in Venda. A case report. ( Bac, DJ; Cox, GA; Isaäcson, M, 1985) |
| " falciparum, parasitemia recurred following treatment with the candidate antimalarial drug enpiroline." | 7.67 | Mefloquine failure in a case of falciparum malaria induced with a multidrug-resistant isolate in a non-immune subject. ( Canfield, CJ; Cosgriff, TM; Pamplin, CL; Willet, GP, 1985) |
| "An American Peace Corps volunteer contracted chloroquine-resistant Plasmodium falciparum malaria while serving in Malawi and taking regular chloroquine prophylaxis." | 7.67 | Chloroquine-resistant falciparum malaria in northern Malawi. ( Ainsworth, B; Breman, JG; Patchen, LC; Teklehaimanot, A; Wolfe, MS, 1985) |
| "Chloroquine-resistant plasmodium falciparum malaria has been described in many parts of the world, including Africa as far south as south-western Africa." | 7.67 | Chloroquine-resistant Plasmodium falciparum malaria in South Africa. A case report. ( Sieling, WL; Visagie, NJ, 1985) |
| "Blood samples from 77 patients with Plasmodium falciparum malaria resident in the Natal/Kwazulu area, were tested for chloroquine resistance by an in vitro microtechnique; 6 of these patients were infected by asexual parasites which proved resistant in varying degrees to chloroquine." | 7.67 | In vitro chloroquine-resistant Plasmodium falciparum malaria in the Natal/Kwazulu area. ( Herbst, JM; Joubert, SM; Taylor, LA, 1985) |
| "In eastern Thailand, falciparum malaria is highly chloroquine-resistant and is quickly becoming quinine-resistant." | 7.67 | Failure of large-dose erythromycin in combination with a standard dose of chloroquine or quinine in the treatment of human falciparum malaria. ( Boudreau, EF; Childs, GE; Pang, LW; Somutsakorn, P; Supanantalerk, C; Webster, HK, 1985) |
| "A cohort of 169 births to women who were exposed throughout pregnancy to chloroquine 300 mg base once a week for chemosuppression of malaria was studied." | 7.67 | Safety of chloroquine in chemosuppression of malaria during pregnancy. ( Cordero, JF; Wolfe, MS, 1985) |
| "The efficacy of chloroquine and pyrimethamine as malaria chemoprophylactics was investigated in young Nigerian children." | 7.67 | A comparison of chloroquine and pyrimethamine as malaria chemoprophylactics in young Nigerian children. ( Akintunde, A; Attai, ED; Bartlett, A; Bidwell, DE; Bradley, AK; Bradley-Moore, AM; Fleming, AF; Greenwood, BM; Kirkwood, BR; Voller, A, 1985) |
| "The initial rates of uptake of L-tryptophan into normal human red blood cells and into cells infected by the malarial parasite Plasmodium falciparum in vitro, were investigated." | 7.66 | Uptake of L-tryptophan by erythrocytes infected with malaria parasites (Plasmodium falciparum). ( Ginsburg, H; Krugliak, M, 1983) |
| "A case of chloroquine-resistant falciparum malaria in a non-immune Swiss tourist is described." | 7.66 | [A case of chloroquine-resistant tropical malaria from eastern Africa (Kenya)]. ( Gorecka, M; Reber-Liske, R; Stuby, K; von Schulthess, F, 1983) |
| "The first two cases from East Africa of RII chloroquine- and Fansidar-resistant falciparum malaria are described." | 7.66 | Combined chloroquine/Fansidar-resistant falciparum malaria appears in East Africa. ( Hess, U; Jones, M; Timmermans, PM, 1983) |
| "A case is reported of Plasmodium falciparum malaria from East Africa resistant to chloroquine in the in vivo test at the RII level." | 7.66 | RII-RIII chloroquine resistant Plasmodium falciparum malaria from East Africa: studies of the in vivo and in vitro response to chloroquine. ( Black, F; Fogh, S; Jepsen, S; Peterslund, N, 1983) |
| "Data concerning 11 cases of cerebral malaria treated with high doses of chloroquine base (18mg/kg/day) are reported." | 7.66 | Cerebral malaria treated with high doses of chloroquine. ( Nuti, S; Savioli, L, 1983) |
| "Twelve children with acute falciparum malaria were treated with 25 mg/kg chloroquine orally in three divided doses at 24 h intervals." | 7.66 | Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria. ( Adeyokunnu, AA; Alvan, G; Dawodu, AH; Salako, LA; Walker, O, 1983) |
| "1 Ten children with Plasmodium falciparum malaria were treated with 25 mg/kg chloroquine over 3 days and observed for 7 days." | 7.66 | Kinetics of the uptake and elimination of chloroquine in children with malaria. ( Adelusi, SA; Dawodu, AH; Salako, LA, 1982) |
| "Bovine serum albumin and preparations of cell sap from malaria parasites and normal erythrocytes were tested for ability to protect cellular membranes against the toxicity of ferriprotoporphyrin IX (FP) and a chloroquine-FP complex." | 7.66 | Ferriprotoporphyrin IX binding substances and the mode of action of chloroquine against malaria. ( Banyal, HS; Fitch, CD, 1982) |
| "Evidence of resistance ot chloroquine was found in 13 out of 14 children from the East New Britain Province of Papua New Guinea, with Plasmodium falciparum malaria." | 7.66 | Chloroquine resistant Plasmodium falciparum malaria in East New Britain, Papua New Guinea. ( Tulloch, A, 1980) |
| "The prevalence of chloroquine-resistant falciparum malaria was determined for humans living at 28 different sites in the Brazilian Amazon." | 7.66 | Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon. ( Ferraroni, JJ; Hayes, J; Speer, CA; Suzuki, M, 1981) |
| "Two cases of chloroquine-resistant Plasmodium falciparum malaria have been reported from eastern Papua New Guinea in order to alert the medical profession about the spread of resistant strains throughout that territory." | 7.66 | The spread of chloroquine-resistant falciparum malaria in Papua New Guinea. ( Simpson, M; Williams, P, 1978) |
| "A case of chloroquine-resistant Plasmodium falciparum malaria in a non-immune male is reported." | 7.66 | Chloroquine-resistant Plasmodium falciparum malaria in Kenya. ( Effersøe, P; Fogh, S; Jepsen, S, 1979) |
| "Chloroquine is considered essentially nontoxic when used for the chemosuppression of malaria, but gastrointestinal upsets, headache, blurring of vision, pruritus, and uritcaria may occur during chloroquine therapy." | 7.66 | Extrapyramidal syndrome following chloroquine therapy. ( Singh, M; Singhi, P; Singhi, S, 1979) |
| "Chloroquine resistance has arisen in both human and murine forms of malaria." | 7.65 | Host heme catabolism in drug-sensitive and drug-resistant malaria. ( Berger, E; Eaton, JW; Eckman, JR; Engel, RR; Modler, S, 1977) |
| "Attention has once again been directed to the very uncomfortable itching following chloroquine chemotherapy of malaria in about 8% of the Nigeria population." | 7.65 | The practical and therapeutic implications of chloroquine-induced itching in tropical Africa. ( Olatunde, A, 1977) |
| "The infectivity of 25 falciparum malaria patients for Anopheles balabacensis and Anopheles minimus, before and after chloroquine therapy, was studied in central Thailand." | 7.65 | Infectivity of falciparum malaria patients for anopheline mosquitoes before and after chloroquine treatment. ( Gould, DJ; Noeypatimanondh, S; Wilkinson, RN, 1976) |
| "Clindamycin, a semi-synthetic antibiotic of the lincomycin family, at a dose of 450 mg eight-hourly for three days in adults cured five out of 10 patients moderately ill with chloroquine-resistant falciparum malaria." | 7.65 | Falciparum malaria semi-resistant to clindamycin. ( Doberstyn, EB; Hall, AP; Nanokorn, A; Sonkom, P, 1975) |
| "A female patient with Plasmodium falciparum malaria apparently resistant to chloroquine is descirbed." | 7.65 | Probable chloroquine-resistant Plasmodium falciparum malaria from Mozambique A case report. ( Bhoola, RL; Pillay, N, 1975) |
| "The efficacy of chloroquine in the treatment of falciparum malaria was studied in two villages in Northeast Thailand, an area endemic for chloroquine-resistant falciparum infections." | 7.65 | Longitudinal malaria studies in rural Northeast Thailand. Chloroquine treatment of falciparum malaria infections. ( Gresso, WE; Segal, HE; Thiemanun, W, 1975) |
| "Malaria and its local vector, Anopheles darlingi, were eradicated from the coastlands and near interior of Guyana by DDT house-spraying in 1945-51." | 7.64 | Interruption of malaria transmission by chloroquinized salt in Guyana, with observations on a chloroquine-resistant strain of Plasmodium falciparum. ( Giglioli, G; Ramjattan, S; Rutten, FJ, 1967) |
| "The authors present the results of a study carried out to determine the efficacy of chloroquine- and pyrimethamine-salt mixtures as a suppressive against sporozoite-induced vivax malaria (Chesson strain)." | 7.63 | Chloroquine or pyrimethamine in salt as a supressive against sporozoite-induced vivax malaria (Chesson strain). ( BURGESS, RW; COATNEY, GR; MICKELSEN, O; PIRKLE, CI; YOUNG, MD, 1958) |
| " Within a decade of its introduction, reports of the side effects associated with its long-term use surfaced." | 6.72 | Mefloquine as a prophylaxis for malaria needs to be revisited. ( Ahmad, SS; Rahi, M; Ranjan, V; Sharma, A, 2021) |
| "Malaria is a major cause of morbidity and mortality among children under five in sub-Saharan Africa." | 6.70 | Improving adherence to malaria treatment for children: the use of pre-packed chloroquine tablets vs. chloroquine syrup. ( Agyepong, IA; Ansah, EK; Evans, DB; Gyapong, JO, 2001) |
| " Despite the dosage employed, the frequency and duration of use, and excretion primarily through the bowels as the active parent compound, primaquine appeared to have little or no significant effect against a variety of common intestinal parasites." | 6.69 | Intestinal parasite infections after extended use of chloroquine or primaquine for malaria prevention. ( Basri, H; Fryauff, DJ; Jones, TR; Mouzin, E; Prodjodipuro, P; Subianto, B; Widjaja, H, 1998) |
| "Chloroquine was given under observation at a weekly oral dose of 300 mg." | 6.68 | Increase of birth weight following chloroquine chemoprophylaxis during the first pregnancy: results of a randomized trial in Cameroon. ( Breart, G; Cot, M; Esveld, M; Etya'ale, D; Le Hesran, JY; Miailhes, P, 1995) |
| "Chloroquine has been reported to antagonise the anti-parasitic action of quinine against Plasmodium falciparum in vitro." | 6.67 | Efficacy of quinine for falciparum malaria according to previous chloroquine exposure. ( Mansor, S; Molyneux, ME; Taylor, TE; Thomas, CG; Wirima, JJ, 1991) |
| "Malaria is a threat to human mankind and kills about half a million people every year." | 6.66 | Insights in Chloroquine Action: Perspectives and Implications in Malaria and COVID-19. ( de Souza, EE; Guimarães, LMF; Krüger, A; Lameu, C; Pillat, MM; Ulrich, H; Wrenger, C, 2020) |
| "Clinical malaria was documented significantly less frequently in protected children than in control children, and only 9% of random blood films obtained from protected children were positive for Plasmodium falciparum while 41% of random blood films from control children were positive for this parasite." | 6.66 | Malaria chemoprophylaxis with chloroquine in young Nigerian children. I. Its effect on mortality, morbidity and the prevalence of malaria. ( Bartlett, A; Bidwell, DE; Bradley, AK; Bradley-Moore, AM; Gilles, HM; Greenwood, BM; Kirkwood, BR; Voller, A, 1985) |
| "Treatment of malaria has involved chemotherapy since 168 BC, with the most prevalent and successful forms using plant alkaloids." | 6.55 | The "pushmi-pullyu" of resistance to chloroquine in malaria. ( Callaghan, R; Skrzypek, R, 2017) |
| "Chloroquine resistance has been genetically linked to mutations in a parasite protein (PfCRT) that might confer resistance by inhibiting chloroquine accumulation in infected erythrocytes." | 6.42 | Can a proteomics strategy be used to identify the anti-malarial activity of chloroquine? ( Petri, WA, 2003) |
| "Chloroquine treatment causes the activity of the catalyst to decrease by 80 to 90 percent." | 6.40 | Involvement of heme in the antimalarial action of chloroquine. ( Fitch, CD, 1998) |
| "Malaria is a global health challenge with endemicity in sub-Saharan Africa, where there are multiple drug-resistant strains and limited access to modern health care facilities, especially in rural areas." | 5.91 | Anti-malarial and haematological evaluation of the ethanolic, ethyl acetate and aqueous fractions of Chromolaena odorata. ( Adeyemi, OS; Elebiyo, TC; Oluba, OM, 2023) |
| "Rutin was examined in this work for its anti-plasmodial activity against chloroquine-sensitive and resistant Plasmodium falciparum strains, as well as its anti-oxidative and anti-inflammatory activity against LPS-stimulated macrophage cells." | 5.72 | Rutin ameliorates malaria pathogenesis by modulating inflammatory mechanism: an in vitro and in vivo study. ( Bawankule, DU; Bhatt, D; Bisht, S; Kumar, A; Kumar, P; Kumar, S; Maurya, AK; Pal, A, 2022) |
| "Tafenoquine, co-administered with chloroquine, is approved for the radical cure (prevention of relapse) of Plasmodium vivax malaria." | 5.69 | Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study. ( Baird, JK; Berni, A; Budiman, W; Cedar, E; Chand, K; Crenna-Darusallam, C; Duparc, S; Ekawati, LL; Elyazar, I; Fernando, D; Fletcher, K; Goyal, N; Green, JA; Instiaty, I; Jones, S; Kleim, JP; Lardo, S; Martin, A; Noviyanti, R; Prasetya, CB; Rolfe, K; Santy, YW; Satyagraha, AW; Sharma, H; Soebandrio, A; Subekti, D; Sutanto, I; Tan, LK; Taylor, M, 2023) |
| "Chloroquine was measured by high-performance liquid chromatography." | 5.62 | Exposure to chloroquine in male adults and children aged 9-11 years with malaria due to Plasmodium vivax. ( Ferreira Vieira, MVD; Vieira, JLF, 2021) |
| "Malaria is a disease that requires new drugs not only to fight Plasmodium but also to reduce symptoms of infection such as fever and inflammation." | 5.56 | Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission. ( Bastos, MM; Boechat, N; Carvalho, RCC; Coutinho, JP; Ferreira, MLG; Krettli, AU; Pinheiro, LCS; Rosas, EC; Sa, PM; Seito, LN, 2020) |
| " We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an optimal maternal/fetal dosing regimen to prevent ZIKV endocytosis in brain cells." | 5.51 | Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection. ( Badhan, RKS; Olafuyi, O, 2019) |
| " In the search, we used the keywords: (Plasmodium Berghei) AND (Malaria) AND (Parasitemia) AND (antimalarial activity) AND (nanoparticles) AND (Solid lipid NPS) AND (Nano lipid carriers) AND (Artemether) AND (Chloroquine) AND (intraperitoneal) AND (in vivo)." | 5.41 | New Strategies in the Treatment of ( Azarhazin, M; Cheraghipour, K; Fallahi, S; Khan, IA; Mardanshah, O; Marzban, A; Shakib, P, 2023) |
| "Pyronaridine-artesunate was recently strongly recommended in the 2022 update of the WHO Guidelines for the Treatment of Malaria, becoming the newest artemisinin-based combination therapy (ACT) for both uncomplicated Plasmodium falciparum and Plasmodium vivax malaria." | 5.41 | Pyronaridine: a review of its clinical pharmacology in the treatment of malaria. ( Chu, WY; Dorlo, TPC, 2023) |
| " A 4-day dosage of 1,200 mg/kg of the extract showed, in the P." | 5.40 | Antimalarial efficacy, cytotoxicity, and genotoxicity of methanolic stem bark extract from Hintonia latiflora in a Plasmodium yoelii yoelii lethal murine malaria model. ( Beltrán, HI; Fortoul, TI; López, PY; Malagón, F; Reyes, AJ; Reynada, DY; Rivera, E; Rivera, N; Rojas, M, 2014) |
| "The chloroquine was treated by the actual drug content of effective nanochloroquine and the nanodrug was charged with its effective dose for fifteen days, after successive infection development in Swiss mice." | 5.39 | A novel chitosan based antimalarial drug delivery against Plasmodium berghei infection. ( Chattopadhyay, S; Das, S; Dash, SK; Mahapatra, SK; Majumder, S; Pramanik, P; Roy, S; Tripathy, S, 2013) |
| "Febrifugine is an alkaloid isolated from Dichroa febrifuga Lour as the active component against Plasmodium falciparum, but exhibits toxic side effects." | 5.38 | Febrifugine analogue compounds: synthesis and antimalarial evaluation. ( Chandrashekar, G; Chatterji, D; Meng, L; Robinson, K; Zhu, S, 2012) |
| "Parasitemia was 4% on day 8 when compared to that on day 0, whereas it was 9% on day 9." | 5.38 | Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis. ( Abolghasemi, E; Davoudi, M; Moosa-Kazemi, SH; Reisi, A; Satvat, MT, 2012) |
| "Prodiginines are a family of linear and cyclic oligopyrrole red-pigmented compounds." | 5.37 | Antimalarial activity of natural and synthetic prodiginines. ( Alhamadsheh, M; Challis, GL; Haynes, SW; Kelly, JX; Papireddy, K; Reynolds, KA; Salem, SM; Smilkstein, M, 2011) |
| " Pharmacokinetic studies in rats revealed good oral bioavailability (51% at 22 mg/kg) with a moderate rate of absorption, reasonable half-life (t(1/2) 3 h), and high volume of distribution with moderately high plasma and blood clearance after IV administration." | 5.37 | Novel orally active antimalarial thiazoles. ( Burrows, JN; Charman, SA; Chibale, K; Douelle, F; Feng, TS; González Cabrera, D; Nchinda, AT; Ryan, E; Waterson, D; White, KL; Wittlin, S; Witty, MJ; Wu, Q; Younis, Y, 2011) |
| "Febrifugine is an alkaloid isolated from Dichroa febrifuga Lour as the active component against Plasmodium falciparum." | 5.35 | Synthesis and biological evaluation of febrifugine analogues as potential antimalarial agents. ( Gudise, C; Smith, E; Wei, L; Zeng, Y; Zhang, Q; Zhu, S, 2009) |
| "Immunity to malaria has long been thought to be stage-specific." | 5.35 | Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage. ( Belnoue, E; Costa, FT; Depinay, N; Grüner, AC; Kayibanda, M; Mauduit, M; Mazier, D; Rénia, L; Rosa, DS; Sinnis, P; Snounou, G; Vigário, AM; Voza, T, 2008) |
| "Malaria is a leading cause of death in Sub-Saharan Africa." | 5.33 | How sulfadoxine-pyrimethamine (SP) was perceived in some rural communities after phasing out chloroquine (CQ) as a first-line drug for uncomplicated malaria in Tanzania: lessons to learn towards moving from monotherapy to fixed combination therapy. ( Nsimba, SE, 2006) |
| " The study findings showed that antimalarial property of goniothalamin was enhanced by combination with chloroquine at lower dose of each drug." | 5.33 | Antimalarial properties of Goniothalamin in combination with chloroquine against Plasmodium yoelii and Plasmodium berghei growth in mice. ( Khozirah, S; Mohd Ridzuan, MA; Noor Rain, A; Ruenruetai, U; Zakiah, I, 2006) |
| "Malaria is a major tropical disease, which kills two million people annually." | 5.31 | Aminonaphthoquinones--a novel class of compounds with potent antimalarial activity against Plasmodium falciparum. ( Azuine, MA; Balasubramanian, V; Kapadia, GJ; Sridhar, R, 2001) |
| "Chloroquine-treated and artemether-treated parasites displayed a pigment-clumping morphology and lowered the parasitaemia faster than dioncophylline B." | 5.31 | A comparison of the stage-specific efficacy of chloroquine, artemether and dioncophylline B against the rodent malaria parasite Plasmodium chabaudi chabaudi in vivo. ( Bringmann, G; Chimanuka, B; François, G; Heyden, YV; Holenz, J; Plaizier-Vercammen, J; Timperman, G, 2001) |
| "Spermidine was detected in about five-fold higher concentrations than putrescine and spermine which were detected in equimolar levels." | 5.30 | Polyamine metabolism in various tissues during pathogenesis of chloroquine-susceptible and resistant malaria. ( Chandra, S; Mishra, M; Pandey, VC; Tekwani, BL, 1997) |
| " While most patients with tertian malaria were cured with the standard chloroquine and primaquine regimen, a higher dosage was required for one case acquired in Papua New Guinea." | 5.30 | Imported malaria: successful treatment of 31 patients in the era of chloroquine resistance. ( Chang, HL; Chang, SC; Chen, YC; Fang, CT; Hsieh, WC; Hsueh, PR; Hung, CC, 1999) |
| " The concentration-time course was fitted to a multiple-dose pharmacokinetic model." | 5.29 | The pharmacokinetics of three multiple dose regimens of chloroquine: implications for malaria chemoprophylaxis. ( De Vries, PJ; Oosterhuis, B; Van Boxtel, CJ; Wetsteyn, JC, 1995) |
| " The chloroquine delivered in these liposomes intravenously at a dosage of 5 mg/kg of body weight per day on days 4 and 6 postinfection completely cured the animals (75 to 90%) of chloroquine-resistant P." | 5.29 | Chloroquine encapsulated in malaria-infected erythrocyte-specific antibody-bearing liposomes effectively controls chloroquine-resistant Plasmodium berghei infections in mice. ( Chandra, S; Choudhury, A; Gupta, CM; Owais, M; Varshney, GC, 1995) |
| "Chloroquine treatment did not cause any significant alteration in the above-mentioned enzymes of normal mice." | 5.29 | Effect of Plasmodium berghei infection and antimalarial treatment on heme synthesis in mice. ( Pandey, VC; Puri, SK; Srivastava, P, 1994) |
| " To reduce the side effects, another test was carried out in 3 monkeys and the dosage regimen was modified to pyronaridine 6 mg/kg-artemether 10 mg/kg-chloroquine 20 mg/kg (PAC-2) once daily for 3 days." | 5.29 | [Studies on the establishment of malarial animal model of short-term relapse. III. Combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance]. ( Fang, Y; Lin, BY; Pan, YR; Zhang, JX; Zheng, H, 1993) |
| "Chloroquine treatment of malarious mice reduces by 80 percent the activity of this enzyme, without inhibiting release of FP from hemoglobin, and thereby causes excess nonpolymerized, nonhemozoin FP to accumulate." | 5.28 | Heme polymerase: modulation by chloroquine treatment of a rodent malaria. ( Chou, AC; Fitch, CD, 1992) |
| "Chloroquine alone was successful in 83% of cases and chloroquine-spiramycin in 95% of cases (statistically significant)." | 5.28 | [Assessment of a chloroquine-spiramycin combination in the treatment of malaria in an area of moderate resistance]. ( Faurant, C; Kabeya, K; Kankolongo, L; Krim, G; Tshibemba, M, 1990) |
| "Homoharringtonine, 2." | 5.28 | Treatment of chloroquine-resistant malaria with esters of cephalotaxine: homoharringtonine. ( Brown, ND; Whaun, JM, 1990) |
| "Desethylchloroquine and BDCQ were concentrated in the red cells of uninfected blood to the same extent as chloroquine." | 5.28 | Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. ( Ajayi, FO; Kuye, JO; Salako, LA, 1989) |
| "Chloroquine (CQ) solution was separately mixed with the serum of mice infected with chloroquine-resistant 'NS' line (SMNS), the serum of mice infected with chloroquine-sensitive Plasmodium berghei ANKA strain (SMCS), and the serum of normal mice (SM)." | 5.28 | Antagonism of serum of mice infected with chloroquine-resistant 'NS' line to the antimalarial action of chloroquine. ( Chen, L; Li, GD; Qian, YL, 1989) |
| "Chloroquine tablets were distributed by health workers belonging to the community." | 5.28 | [The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission]. ( Baudon, D; Carnevale, P; Hervy, JP; Legros, F; Robert, V; Roux, J, 1989) |
| "A randomized controlled trial was conducted in 3 district hospitals in Sabah, Malaysia to compare the efficacy of AL against chloroquine (CQ) for uncomplicated knowlesi malaria." | 5.27 | Artemether-Lumefantrine Versus Chloroquine for the Treatment of Uncomplicated Plasmodium knowlesi Malaria: An Open-Label Randomized Controlled Trial CAN KNOW. ( Anstey, NM; Barber, BE; Chandna, A; Grigg, MJ; Menon, J; Patel, K; Price, RN; Rajahram, GS; Schimann, E; Wilkes, CS; William, T; Yeo, TW, 2018) |
| "Chloroquine administered as intermittent therapy did not provide better protection from malaria and related adverse effects compared with intermittent sulfadoxine-pyrimethamine in a setting of high resistance to sulfadoxine-pyrimethamine." | 5.27 | Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial. ( Boudová, S; Divala, TH; Goswami, J; Kanjala, M; Kennedy, J; Laufer, MK; Masonga, R; Mawindo, PM; Mbilizi, Y; Muehlenbachs, A; Mungwira, RG; Muwalo, F; Mvula, P; Ndaferankhande, M; Ndovie, L; Nyirenda, OM; Potter, GE; Tomoka, T; Tsirizani, LE; Wylie, BJ, 2018) |
| " A 25-mg base/kg dosage of amodiaquine produced parasite clearance in 34 of 38 (89%) children in a mean of 2." | 5.27 | Evaluation of amodiaquine treatment of chloroquine-resistant Plasmodium falciparum malaria on Zanzibar, 1982. ( Campbell, CC; Khatib, OJ; Payne, D; Schwartz, IK, 1983) |
| "The malaria was resistant to chloroquine at the RI level, the first such case reported from BMH Dharan." | 5.27 | Chloroquine resistant malignant subtertian malaria unmasked by systematic steroid therapy. ( Henderson, A; Livesey, JR, 1983) |
| " falciparum infections during the year died, and (v) increasing the dosage of chloroquine base from 15 to 25 to 37." | 5.27 | Absence of malaria mortality in villagers with chloroquine-resistant Plasmodium falciparum treated with chloroquine. ( Campbell, JR; Harun, S; Hoffman, SL; Hussein, PR; Marwoto, HA; Masbar, S; Smrkovski, L; Soewarta, A; Wiady, I, 1984) |
| "Desipramine was found to be one of the most effective compounds yet described for the reversal of chloroquine resistance both in vitro and in vivo." | 5.27 | Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine. ( Bitonti, AJ; Davidson, DE; Kyle, DE; McCann, PP; Milhous, WK; Oduola, AM; Rossan, RN; Sjoerdsma, A, 1988) |
| "Chloroquine resistance was first detected in 1981 and this increased markedly in 1982." | 5.27 | Serial studies on the evolution of chloroquine resistance in an area of East Africa receiving intermittent malaria chemosuppression. ( Brubaker, G; Draper, CC; Geser, A; Kilimali, VA; Wernsdorfer, WH, 1985) |
| "Chloroquine treatment (25 mg base/kg body-weight) giving serum concentrations of 0." | 5.26 | Serum concentrations of chloroquine in a patient with a late recrudescence of Kenyan Plasmodium falciparum malaria. ( Faehlmann, M; Hedman, P; Rombo, L, 1981) |
| " A sigmoidal dose-response curve is followed with 50% hemolysis being produced by 4 microM FP." | 5.26 | Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications. ( Chou, AC; Fitch, CD, 1980) |
| "When sulfalene was administered during malaria, this difference was no longer apparent." | 5.26 | The influence of acetylator phenotype on the response to sulfalene in individuals with chloroquine-resistant falciparum malaria. ( Carson, PE; Frischer, H; Rieckmann, KH; Trenholme, GM; Williams, RL, 1978) |
| "The treatment of chloroquine resistant malaria in West Malaysia is a subject of another paper but suffice it to say that increased doses of chloroquine have still been found to be effective in treating many cases of falciparum malaria from areas of chloroquine resistance." | 5.25 | Chloroquine resistant malaria in West Malaysia. ( Ali, AR; Fredericks, HJ; Ismail, O; Othman, AM; Ponnampalam, JT; Sandosham, AA; Seow, CL, 1975) |
| "Chloroquine-(14)C was used to study the processes which concentrate chloroquine in mouse red blood cells infected with chloroquine-sensitive or with chloroquine-resistant Plasmodium berghei." | 5.25 | Chloroquine resistance in malaria: a deficiency of chloroquine binding. ( Fitch, CD, 1969) |
| "A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries." | 5.22 | Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review. ( Bwire, GM; Chamani, AT; Mutagonda, RF; Mwakyandile, T; Njiro, BJ; Sabas, D, 2022) |
| " Patients aged 1 year or older with uncomplicated P knowlesi malaria were randomly assigned, via computer-generated block randomisation (block sizes of 20), to receive oral artesunate-mefloquine (target dose 12 mg/kg artesunate and 25 mg/kg mefloquine) or chloroquine (target dose 25 mg/kg)." | 5.22 | Artesunate-mefloquine versus chloroquine for treatment of uncomplicated Plasmodium knowlesi malaria in Malaysia (ACT KNOW): an open-label, randomised controlled trial. ( Anstey, NM; Barber, BE; Dhanaraj, P; Grigg, MJ; McCarthy, JS; Menon, J; Pasay, C; Price, RN; Rajahram, GS; von Seidlein, L; Wilkes, CS; William, T; Yeo, TW, 2016) |
| "Chloroquine has been the treatment of choice for acute vivax malaria for more than 60 years." | 5.22 | Comparison of the safety and efficacy of fixed-dose combination of arterolane maleate and piperaquine phosphate with chloroquine in acute, uncomplicated Plasmodium vivax malaria: a phase III, multicentric, open-label study. ( Anvikar, AR; Arora, S; Gogtay, N; Iyer, SS; Jalali, RK; Kochar, SK; Kumar, NB; Lakhani, JD; Rajadhyaksha, GC; Rao, BH; Roy, A; Saha, N; Savargaonkar, D; Sharma, P; Solanki, BB; Srivastava, B; Tripathi, SK; Valecha, N, 2016) |
| " Asiatic acid suppressed parasitaemia while oral chloroquine (30 mg/kg) did not influence malaria induction." | 5.22 | Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats. ( Mabandla, MV; Mavondo, GA; Mkhwananzi, BN, 2016) |
| "Chloroquine-azithromycin is being evaluated as combination therapy for malaria." | 5.19 | Chloroquine-azithromycin combination antimalarial treatment decreases risk of respiratory- and gastrointestinal-tract infections in Malawian children. ( Claassen, CW; Dzinjalamala, FK; Gilliams, EA; Jumare, J; Laufer, MK; Nyirenda, OM; Plowe, CV; Taylor, T; Thesing, PC; Tracy, LA, 2014) |
| "Chloroquine combined with primaquine has been the standard radical curative regimen for Plasmodium vivax and Plasmodium ovale malaria for over half a century." | 5.19 | Pharmacokinetic interactions between primaquine and chloroquine. ( Ashley, EA; Charunwatthana, P; Day, NP; Hanboonkunupakarn, B; Hanpithakpong, W; Jittamala, P; Lawpoolsri, S; Lee, SJ; Pukrittayakamee, S; Tarning, J; White, NJ, 2014) |
| "The predominance of chloroquine-susceptible falciparum malaria in Malawi more than a decade after chloroquine's withdrawal permits contemplation of re-introducing chloroquine for targeted uses." | 5.16 | A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria. ( Dzinjalamala, FK; Laufer, MK; Laurens, MB; Masonga, R; Nyirenda, OM; Plowe, CV; Stokes-Riner, A; Taylor, TE; Thesing, PC, 2012) |
| "To compare the efficacy of monthly SP presumptive treatment, versus weekly chloroquine for malaria prophylaxis in children attending the Sickle Cell Clinic, Mulago Hospital." | 5.14 | Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial. ( Nakiboneka, D; Nakibuuka, V; Ndeezi, G; Ndugwa, CM; Tumwine, JK, 2009) |
| "Chloroquine plus primaqine is an inexpensive and highly effective treatment for uncomplicated knowlesi malaria infections in humans and there is no evidence of drug resistance." | 5.14 | Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections. ( Cox-Singh, J; Daneshvar, C; Davis, TM; Divis, PC; Rafa'ee, MZ; Singh, B; Zakaria, SK, 2010) |
| "The in vivo therapeutic efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination was evaluated in the treatment of uncomplicated Plasmodium falciparum malaria and of chloroquine for P." | 5.13 | [Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006]. ( Cortés, LJ; Guerra, AP; Knudson, A; Nicholls, RS; Pérez, MA; Usta, C, 2008) |
| "Intermittent preventive treatment with three doses of sulfadoxine-pyrimethamine is a more effective strategy to prevent maternal anemia during pregnancy in Burkina Faso." | 5.13 | [Comparative impact of three malaria preventive regimens during pregnancy on maternal anemia due to malaria in Burkina Faso]. ( Bougouma, EC; Diarra, A; Konaté, AT; Nébié, I; Ouédraogo, A; Sirima, SB; Tiono, AB, 2008) |
| "The study design was an open randomized control trial comparing anaemia incidence among pregnant women on intermittent presumptive treatment of malaria with SP with those on chloroquine (CQ)." | 5.13 | Efficacy of intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine in preventing anaemia in pregnancy among Nigerian women. ( Abiona, TC; Asa, OO; Fatusi, AO; Ijadunola, KT; Onayade, AA, 2008) |
| " The aims were (i) to update our knowledge of the burden of Plasmodium malariae infection and (ii) to assess the therapeutic efficacy of chloroquine for uncomplicated quartan malaria." | 5.12 | Short report: prevalence and chloroquine sensitivity of Plasmodium malariae in Madagascar. ( Barnadas, C; Ménard, D; Picot, S; Rabekotonorina, V; Ralaizandry, D; Ranaivosoa, H; Ratsimbasoa, A; Raveloariseheno, D, 2007) |
| "Atovaquone-proguanil has been shown to be effective and well tolerated for malaria prophylaxis in residents of countries of endemicity and in nonimmune adult travelers, but data about traveling children are limited." | 5.11 | Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study. ( Camus, D; De Boever, EH; Djossou, F; Dutoit, E; Hedgley, C; Høgh, B; Malvy, D; Miller, GB; Roskell, NS; Schilthuis, HJ, 2004) |
| "In Mali, IPT with SP appears more efficacious than weekly chloroquine chemoprophylaxis in preventing malaria during pregnancy." | 5.11 | Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of malaria during pregnancy in Mali. ( Coulibaly, D; Doumbo, O; Doumtabe, D; Kayentao, K; Keita, AS; Kodio, M; Maiga, B; Maiga, H; Mungai, M; Newman, RD; Ongoiba, A; Parise, ME, 2005) |
| " The high endemicity of malaria in Africa may impact on the efficacy of artemisinin-based combination therapy." | 5.11 | Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. ( Bakyaita, N; Banek, K; Dorsey, G; Kamya, MR; Kilian, A; Kironde, F; Nsobya, SL; Reingold, A; Rosenthal, PJ; Slater, M; Staedke, SG; Talisuna, A; Wabwire-Mangen, F; Yeka, A, 2005) |
| "At a public hospital in Georgetown, Guyana, 44 patients seeking treatment for symptomatic, slide-confirmed malaria were given standard chloroquine (CQ) therapy and followed for 28 days." | 5.10 | Chloroquine for the treatment of uncomplicated malaria in Guyana. ( Baird, JK; Bravet, PP; Carucci, D; Ferrel, M; Hoffman, SL; Martin, GJ; Prout, TM; Rawlins, S; Tamminga, CL; Tiwari, T; Tjaden, J, 2002) |
| "Children with symptomatic malaria in Bissau were randomly assigned to treatment with chloroquine 25 mg base/kg given supervised at a health centre or unsupervised by the mothers at home." | 5.10 | Can mothers be trusted to give malaria treatment to their children at home? ( Aaby, P; Hedegaard, K; Kofoed, PE; Lopez, F; Rombo, L, 2003) |
| "To improve upon the efficacy of primaquine prophylaxis for malaria (94%, Plasmodium falciparum malaria; 85%, Plasmodium vivax malaria), we administered chloroquine (300 mg weekly) in combination with primaquine (30 mg daily) to nonimmune Colombian soldiers during 16 weeks of patrol in a region of endemicity and for a further 1 week in base camp." | 5.09 | Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in nonimmune Colombian soldiers. ( Berman, J; Herrera, R; Padilla, J; Rodriquez, M; Sanchez, J; Soto, J; Toledo, J, 1999) |
| "In 1996, Zambia's Ministry of Health made sulfadoxine-pyrimethamine (SP) available as a second-line antimalarial." | 5.09 | A community perspective on the efficacy of malaria treatment options for children in Lundazi district, Zambia. ( Hightower, A; Kachur, SP; Mphande, PC; Nalwamba, NC; Simoonga, C; Williams, HA, 1999) |
| "Consumption of chloroquine (CQ) and subtherapeutic drug levels in blood are considered to be widespread in areas where malaria is endemic." | 5.09 | Concentrations of chloroquine and malaria parasites in blood in Nigerian children. ( Ademowo, OG; Bergqvist, Y; Bienzle, U; Falusi, AG; Grossterlinden, L; May, J; Meyer, CG; Mockenhaupt, FP; Olumese, PE, 2000) |
| " INTERVENTION MEASURES: The intervention measures were intermittent and continuous malaria chemoprophylaxis using chloroquine and proguanil." | 5.09 | Randomised trial of alternative malaria chemoprophylaxis strategies among pregnant women in Kigoma, Tanzania: I. Rationale and design. ( Kabalimu, TK; Mnyika, KS; Mpanju-Shumbusho, W; Rukinisha, K, 2000) |
| "A randomized, double-blind, placebo-controlled trial, which compared the effects of three interventions (weekly chloroquine prophylaxis, daily iron and weekly folic-acid supplementation, and case management of malaria) on congenital malaria, maternal haemoglobin (Hb) and foetal outcome, was conducted among primigravidae resident in Hoima district, Uganda." | 5.09 | Chloroquine prophylaxis, iron/folic-acid supplementation or case management of malaria attacks in primigravidae in western Uganda: effects on congenital malaria and infant haemoglobin concentrations. ( Magnussen, P; Ndyomugyenyi, R, 2000) |
| "One hundred patients were included in a randomised trial to identify surgical factors inducing malaria and assess the impact of chloroquine prophylaxis in Niamey where resistance to the drug is moderate." | 5.09 | [Value of malaria prophylaxis in surgical intervention in a malaria endemic zone , Niamey, Niger]. ( Bougarel, J; Chippaux, JP; Djibo, A; Madougou, B, 2001) |
| "Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 5.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
| "Immune suppression and disturbances of normal leukocyte populations are side effects attributed to many antimalarial drugs and were concerns during a recent year-long placebo-controlled trial that compared daily primaquine (0." | 5.08 | Lymphocyte proliferative response and subset profiles during extended periods of chloroquine or primaquine prophylaxis. ( Baird, JK; Fryauff, DJ; Hadiputranto, H; Hoffman, SL; Larasati, RP; Mouzin, E; Pudjoprawoto, N; Ratiwayanto, S; Richards, AL; Richie, TL; Subianto, B; Sutamihardja, MA; Tjitra, E, 1996) |
| "We conducted a double-blind, randomized, parallel group study to examine and compare the antipruritic effects of promethazine, niacin, prednisolone and their combination on pruritus induced by chloroquine, in 28 historical itching patients with parasitologically proven malaria fever." | 5.08 | Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine. ( Adebayo, RA; Ajayi, AA; Onayemi, O; Sofowora, GG; Udoh, SJ, 1997) |
| "Immune suppression, a potential side effect of long-term chemoprophylaxis, was evaluated as part of a randomized, placebo-controlled trial that compared daily primaquine against weekly chloroquine for malaria prevention." | 5.08 | Lymphocyte response to tetanus toxoid among Indonesian men immunized with tetanus-diphtheria during extended chloroquine or primaquine prophylaxis. ( Church, LW; Fryauff, DJ; Hadiputranto, H; Hoffman, SL; Mouzin, E; Ratiwayanto, S; Richards, AL; Richie, TL; Subianto, B; Sutamihardja, MA; Tjitra, E; Widjaja, H, 1997) |
| "Immune suppression resulting from prolonged chemoprophylaxis and potential drug-vaccine interaction were investigated within the context of a randomized placebo-controlled trial that compared daily primaquine or weekly chloroquine administration for malaria prevention." | 5.08 | Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis. ( Church, LW; Cryz, SJ; Fryauff, DJ; Hoffman, SL; Mouzin, E; Richards, AL; Subianto, B; Sutamihardja, MA; Widjaja, H, 1998) |
| "In a controlled trial of weekly malaria chemoprophylaxis with chloroquine and pyrimethamine there were no significant differences in type and frequency of severe morbidity during chemoprophylaxis." | 5.07 | Severe morbidity among children in a trial malaria chemoprophylaxis with pyrimethamine or chloroquine in Ibarapa, Nigeria. ( Asuzu, MC; Bamgboye, A; Ogunba, EO; Osunkoya, BO; Oyediran, AB; Topley, E; Williams, AI, 1993) |
| "The malaria prophylactic effects of chloroquine (CQ), proguanil (PROG), and chloroquine-proguanil combination (CQ+PROG) during pregnancy on maternal haemoglobin levels (Hb), placental malaria, and birth weight were assessed in Muheza, Tanzania." | 5.07 | Malaria chemosuppression in pregnancy. II. Its effect on maternal haemoglobin levels, placental malaria and birth weight. ( de Geus, A; Malle, LN; Mutabingwa, TK; Oosting, J, 1993) |
| "To determine the effect of chloroquine chemoprophylaxis during pregnancy on birth weights, a randomized trial was carried out in 1987 and 1988 in Banfora, Burkina Faso (West Africa)." | 5.07 | Effect of chloroquine chemoprophylaxis during pregnancy on birth weight: results of a randomized trial. ( Barro, D; Breart, G; Carnevale, P; Cot, M; Roisin, A; Verhave, JP; Yada, A, 1992) |
| "The incidence and nature of pruritus induced by chloroquine and halofantrine were studied in 82 patients with acute malaria and in 40 healthy subjects, using a visual analogue scale for quantitating pruritus." | 5.07 | Halofantrine-induced pruritus amongst subjects who itch to chloroquine. ( Abila, B; Ambakederemo, AW; Ezeamuzie, IC; Igbigbi, PS; Nwaejike, IN, 1991) |
| "Weekly oral chloroquine prophylaxis for malaria has been associated with impaired antibody response to intradermal rabies vaccination." | 5.07 | The effect of chloroquine prophylaxis on yellow fever vaccine antibody response: comparison of plaque reduction neutralization test and enzyme-linked immunosorbent assay. ( Barry, M; Cullen, MR; Patterson, JE; Shope, RE; Tirrell, S, 1991) |
| "One hundred thirty nonimmune subjects living in Yaoundé, Cameroon, completed an 18-month prospective study on the efficacy and safety of weekly chloroquine and daily proguanil (chloroguanide) (Ch-P) in malaria prevention." | 5.07 | Prolonged malaria prophylaxis with chloroquine and proguanil (chloroguanide) in a nonimmune resident population of an endemic area with a high prevalence of chloroquine resistance. ( Fadat, G; Gozal, D; Hengy, C, 1991) |
| "The efficacy of a loading dose of 20 mg of chloroquine per kg of body weight per os given at intervals during the first day was evaluated in 27 patients in Madagascar with Plasmodium falciparum malaria." | 5.07 | Efficacy of a loading dose of oral chloroquine in a 36-hour treatment schedule for uncomplicated plasmodium falciparum malaria. ( Bergqvist, Y; Clavier, F; Frisk-Holmberg, M; Le Bras, J; Lepers, JP; Pussard, E; Raharimalala, L; Verdier, F, 1991) |
| "The efficacy of chlorpheniramine in the prevention of choroquine-induced pruritus was assessed in a trial involving 132 malaria patients with a history of chloroquine-induced pruritus." | 5.07 | The efficacy of piriton on chloroquine-induced pruritus in patients with malaria. ( Mnyika, KS, 1991) |
| "In 17 semi-immune adult volunteers, chemoprophylaxis with 300 mg chloroquine base weekly for six months was found to be effective in suppressing malaria." | 5.06 | The effect of short-term malaria chemoprophylaxis on the immune response of semi-immune adult volunteers. ( Eckerbom, S; Lege-Oguntoye, L; Maiha, BB; Onyemelukwe, GC; Udezue, EO, 1990) |
| "To compare the efficacy and side-effects of two therapeutic regimens for chloroquine-resistant falciparum malaria, a randomized study was carried out in 69 patients in Maputo Central Hospital in 1986-1987." | 5.06 | [Comparative study of sulfadoxine-pyrimethamine and amodiaquine + sulfadoxine-pyrimethamine for the treatment of malaria caused by chloroquine-resistant Plasmodium falciparum in Maputo, Mozambique]. ( Dinis, DV; Schapira, A, 1990) |
| "New studies on the suppressive and curative effects of the anti-malarial drug pyrimethamine in pregnant women from Ilorin, Nigeria showed both ineffective prophylaxis and suppression, and parasite resistance." | 5.06 | Lack of efficacy of pyrimethamine prophylaxis in pregnant Nigerian women. ( Adetoro, O; Akintunde, A; Alakija, T; Breman, JG; Edungbola, LD; Nahlen, BL; Nguyen-Dinh, P; Ogunbode, O, 1989) |
| "5 mg base/kg every 6 h) and intramuscular quinine (20 mg salt/kg followed by 10 mg/kg every 12 h) was carried out in 50 Gambian children with severe falciparum malaria." | 5.06 | Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria. ( Brewster, D; Craddock, C; Krishna, S; Kwiatkowski, D; Waller, D; White, NJ, 1989) |
| "In Nigeria chloroquine remains the drug of choice for the treatment of falciparum malaria since chloroquine resistance is not yet a problem." | 5.06 | Comparison of the susceptibility of falciparum malaria to mefloquine-sulphadoxine-pyrimethamine and chloroquine in Nigeria. ( Aina Adio, R; Fadeke Aderounmu, A; Laoye, AJ; Modupe Makinde, J; Salako, LA, 1988) |
| "188 schoolchildren aged 10-15 living in a malaria endemic area along the Thai-Burmese border were matched for age, splenomegaly, and weight and were then randomly assigned to receive either doxycycline (adult equivalent of 100 mg daily) or chloroquine (adult equivalent of 300 mg base weekly)." | 5.06 | Doxycycline prophylaxis for falciparum malaria. ( Boudreau, EF; Limsomwong, N; Pang, LW; Singharaj, P, 1987) |
| "Two drug strategies for the control of malaria in children aged 3-59 months have been compared in a rural area of The Gambia--treatment of presumptive episodes of clinical malaria with chloroquine by village health workers, and treatment combined with fortnightly chemoprophylaxis with 'Maloprim' (pyrimethamine/dapsone) which was also given by village health workers." | 5.06 | Comparison of two strategies for control of malaria within a primary health care programme in the Gambia. ( Bradley, AK; Byass, P; Greenwood, AM; Greenwood, BM; Hayes, RJ; N'Jie, AB; Snow, RW, 1988) |
| "Halofantrine hydrochloride given to 46 Kenyan children with falciparum malaria at 10 mg/kg for two doses, and to 60 other children at 8 mg/kg for three doses, resulted in rapid parasite clearance, mean parasite clearance times being 45." | 5.06 | Efficacy of multiple-dose halofantrine in treatment of chloroquine-resistant falciparum malaria in children in Kenya. ( Gilles, HM; Kariuki, D; Koech, DK; Lury, JD; Mjomba, M; Mosoba, M; Oloo, JA; Watkins, WM, 1988) |
| "A randomized double blind study in long term malaria chemoprophylaxis was performed to compare the tolerability of Fansimef (1 tablet containing 250 mg mefloquine + 500 mg sulfadoxine + 25 mg pyrimethamine per week) with chloroquine (300 mg per week)." | 5.06 | Tolerability of long-term malaria prophylaxis with the combination mefloquine + sulfadoxine + pyrimethamine (Fansimef): results of a double blind field trial versus chloroquine in Nigeria. ( Kollaritsch, H; Kollaritsch, R; Kremsner, P; Leimer, R; Mailer, H; Stemberger, H; Wiedermann, G, 1988) |
| " Fifty cases of falciparum malaria were treated with 1800 mg amodiaquine for 3 days: the cure rate was 65." | 5.06 | Effectiveness of amodiaquine, sulfadoxine-pyrimethamine, and combinations of these drugs for treating chloroquine-resistant falciparum malaria in Hainan Island, China. ( Cai, XZ; Fu, SG; Huang, JK; Huang, OL; Ouyang, WC; Pang, XJ; Wang, XF; Wu, Z; Zhang, KY; Zhou, JX, 1988) |
| "Chloroquine (25 mg/kg over 3 d) was compared to quinine (10 mg/kg 3 times daily for 5 d) in 20 adult Filipino males with uncomplicated Plasmodium falciparum malaria in a double-blind, randomized trial." | 5.06 | Chloroquine and quinine: a randomized, double-blind comparison of efficacy and side effects in the treatment of Plasmodium falciparum malaria in the Philippines. ( Alban, P; Long, GW; Padre, LP; Ranoa, CP; Sangalang, R; Watt, G, 1988) |
| "The sensitivity of Plasmodium falciparum to quinine in Nigeria was examined in vivo and in vitro prior to the re-introduction of the drug into malaria therapy in that country in the face of spreading chloroquine resistance in Africa." | 5.06 | Evaluation of the sensitivity in vivo and in vitro of Plasmodium falciparum malaria to quinine in an area of full sensitivity to chloroquine. ( Laoye, OJ; Salako, LA; Sowunmi, A, 1988) |
| "In Nigeria chloroquine remains the drug of choice for the treatment of falciparum malaria, since chloroquine resistance is not yet a problem." | 5.06 | Sensitivity of Plasmodium falciparum to mefloquine-sulphadoxine-pyrimethamine (Fansimef) in vivo and to mefloquine alone in vitro in Nigeria. ( Aderounmu, AF; Adio, RA; Laoye, JO; Makinde, JM; Salako, LA, 1988) |
| "As malaria caused by Plasmodium falciparum has become resistant to chloroquine alternative drug regimens need to be developed." | 5.06 | Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine. ( Bygbjerg, IC; Fogh, S; Gøtzsche, PC; Jepsen, S; Kuijlen, K; Mordhorst, CH; Ravn, P; Rønn, A; Schapira, A, 1988) |
| "We studied the effects of daily proguanil compared to weekly chloroquine as malaria prophylaxis in 170 children living in a malaria-endemic area along the Thai-Burmese border." | 5.06 | Malaria prophylaxis with proguanil in children living in a malaria-endemic area. ( Limsomwong, N; Pang, LW; Singharaj, P, 1988) |
| "The standard chloroquine treatment for Plasmodium falciparum malaria is 25 mg (base)/kg (C25) given over 3 days." | 5.06 | Parasitologic and clinical efficacy of 25 and 50 mg/kg of chloroquine for treatment of Plasmodium falciparum malaria in Rwandan children. ( Bugilimfura, L; Deloron, P; Neill, M; Ntilivamunda, A; Sexton, JD, 1988) |
| "Mefloquine is a highly effective drug for the treatment of falciparum malaria among adults, but studies of its effects on children are lacking." | 5.06 | A phase-III clinical trial of mefloquine in children with chloroquine-resistant falciparum malaria in Thailand. ( Attanath, P; Chantavanich, P; Chongsuphajaisiddhi, T; Sabchareon, A; Sheth, UK; Singhasivanon, V; Wernsdorfer, WH, 1987) |
| "The effects of chloroquine, amodiaquine and pyrimethamine-sulfadoxine (SP) (Fansidar) on the infection rate and density of Plasmodium falciparum gametocytes were studied in 198 patients with falciparum malaria from an area in the Punjab where malaria is endemic but seasonally transmitted." | 5.06 | Effects of chloroquine, amodiaquine and pyrimethamine-sulfadoxine on Plasmodium falciparum gametocytemia. ( Fox, E; Khaliq, AA; Macdonald, M; Sarwar, M; Strickland, GT, 1986) |
| "Adults with malaria in Sri Lanka were treated with parenteral chloroquine diphosphate, either 2." | 5.06 | Divided dose intramuscular regimen and single dose subcutaneous regimen for chloroquine: plasma concentrations and toxicity in patients with malaria. ( Abeysekera, DT; Dissanayaka, P; Edwards, G; Galagedera, Y; Phillips, RE; Theakston, RD; Warrell, DA, 1986) |
| "There is no information and therefore no consensus on how chloroquine should be administered to persons with severe malaria." | 5.06 | Parenteral chloroquine for treating falciparum malaria. ( Bergqvist, Y; Njelesani, EK; Watt, G; White, NJ, 1987) |
| "Amodiaquine was compared to chloroquine in two groups of Filipino patients with uncomplicated falciparum malaria." | 5.06 | Amodiaquine less effective than chloroquine in the treatment of falciparum malaria in the Philippines. ( Alban, P; Laughlin, LW; Long, GW; Padre, L; Ranoa, CP; Sangalang, R; Watt, G, 1987) |
| "Since in vitro studies and a preliminary clinical report suggested the efficacy of chloroquine for COVID-19-associated pneumonia, there is increasing interest in this old antimalarial drug." | 5.05 | Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties. ( Knibbe, CAJ; Peeters, MYM; Smit, C; van den Anker, JN, 2020) |
| "Chloroquine and hydroxychloroquine are quinoline derivatives used to treat malaria." | 5.05 | Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection. ( Cook, J; Joshi, A; Nicol, MR; Rizk, ML; Sabato, PE; Savic, RM; Wesche, D; Zheng, JH, 2020) |
| "Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been commonly used for the treatment and prevention of malaria, and the treatment of autoimmune diseases for several decades." | 5.05 | Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19. ( Chen, ZS; Dong, S; Ke, Z; Lei, ZN; Wu, ZX; Yang, DH; Zhang, L; Zou, C, 2020) |
| "A randomized double-blind study was performed to compare the side effects of long-term chemoprophylaxis of malaria with Fansidar (1 tablet a week) with those of a 300-mg weekly chloroquine regimen." | 5.05 | Tolerability of long-term prophylaxis with fansidar: a randomized double-blind study in Nigeria. ( Leimer, R; Stemberger, H; Wiedermann, G, 1984) |
| "The study was carried out to assess the efficacy of quinine in children with Falciparum malaria in relation to in vitro sensitivity (measured in terms of minimum inhibitory concentration: MIC) and to trough serum levels of quinine during the course of treatment." | 5.05 | In vivo and in vitro sensitivity of Falciparum malaria to quinine in Thai children. ( Attanath, P; Chongsuphajaisiddhi, T; Sabcharoen, A, 1981) |
| "A double-blind, randomized, dose-finding, phase II mefloquine trial was carried out in 147 adult male patients suffering from acute, uncomplicated, falciparum malaria and admitted to the Hospital for Tropical Diseases, Bangkok, between January 1980 and April 1981." | 5.05 | A phase II clinical trial of mefloquine in patients with chloroquine-resistant falciparum malaria in Thailand. ( Bunnag, D; Harinasuta, T; Wernsdorfer, WH, 1983) |
| "A total of 99 male Zambian patients with symptomatic falciparum malaria were treated in a double-blind randomized manner with either mefloquine (1000 mg given in one day) or chloroquine (1500 mg given over 3 days)." | 5.05 | A double-blind comparative clinical trial of mefloquine and chloroquine in symptomatic falciparum malaria. ( Kofi Ekue, JM; Rwabwogo-Atenyi, J; Sheth, UK; Ulrich, AM, 1983) |
| "A clinical trial of malaria prophylaxis using a single dose of chloroquine at different intervals was carried out to determine if chloroquine could be given at intervals longer than advocated." | 5.05 | A clinical trial of malaria prophylaxis using a single dose of chloroquine at different intervals in an endemic malarious area. ( Karunakaran, CS, 1980) |
| "The chemotherapy of malaria is incomplete without taking into consideration the widespread presence of chloroquine resistant falciparum malaria necessitating the use of a combination of antimalarials in order to effect a radical cure." | 5.05 | Chemotherapy of malaria. ( Ponnampalam, JT, 1981) |
| "Fifty-eight Nigerian children with Plasmodium falciparum malaria were allocated randomly into two groups and treated with either chloroquine (25 mg/kg over three days) or Fansidar (35 mg sulphadoxin (+ 1/20 pyrimethamine) per kg single dose))." | 5.05 | The in vivo sensitivity of Plasmodium falciparum to chloroquine and to sulphadoxine-pyrimethamine combination in Ibadan, Nigeria. ( Olatunde, A; Salako, LA; Walker, O, 1981) |
| "Chloroquine-resistant Plasmodium falciparum malaria is increasing in prevelance in Papua New Guinea and alternative therapies for acute malaria are being sought." | 5.05 | Sulfadoxine-pyrimethamine for the treatment of acute malaria in children in Papua New Guinea. I. Plasmodium falciparum. ( Alpers, M; Darlow, B; Gibney, S; Jolley, D; Stace, J; Vrbova, H, 1982) |
| "Responses of parasitemia and fever in vivax malaria to standard doses of chloroquine and different dosage schedules of co-trimoxazole were compared in 165 children." | 5.05 | A comparative trial of oral chloroquine and oral co-trimoxazole in vivax malaria in children. ( Lal, H, 1982) |
| " In one trial mefloquine was compared with chloroquine in 40 patients with Plasmodium vivax malaria and in the other one mefloquine was compared with MSP in 40 patients with P falciparum malaria." | 5.05 | Trials of mefloquine in vivax and of mefloquine plus 'fansidar' in falciparum malaria. ( Bunnag, D; Harinasuta, T; Lasserre, R; Leimer, R; Vinijanont, S, 1985) |
| "The immune response of 198 young Nigerian children protected against malaria by chemoprophylaxis with chloroquine to immunization with triple, poliomyelitis, measles, typhoid, meningococcal and BCG vaccines was compared with the immune response to vaccination of 185 control children." | 5.05 | Malaria chemoprophylaxis with chloroquine in young Nigerian children. II. Effect on the immune response to vaccination. ( Bartlett, A; Bidwell, DE; Bradley, AK; Bradley-Moore, AM; Craske, J; Gilles, HM; Greenwood, BM; Kirkwood, BR; Voller, A, 1985) |
| "Haematological measurements were made in 198 Nigerian children aged three months to two years who received weekly malaria chemoprophylaxis with chloroquine from shortly after birth until the age of one or two years and in 185 age-matched control children." | 5.05 | Malaria chemoprophylaxis with chloroquine in young Nigerian children. IV. Its effect on haematological measurements. ( Akintunde, A; Attai, ED; Bradley, AK; Bradley-Moore, AM; Fleming, AF; Flynn, FV; Gilles, HM; Greenwood, BM; Kirkwood, BR, 1985) |
| "A clinical field trial was conducted to determine if mefloquine is effective in the treatment of malaria due to Plasmodium vivax." | 5.05 | A clinical trial of mefloquine in the treatment of Plasmodium vivax malaria. ( Dixon, KE; Phintuyothin, P; Pitaktong, U, 1985) |
| "Forty-six patients with Plasmodium vivax malaria were evaluated for their clinical and parasitological response to the two single doses of mefloquine in comparison with the standard 3-day treatment with chloroquine." | 5.05 | A comparative clinical study of mefloquine and chloroquine in the treatment of vivax malaria. ( Alcantara, AK; Cross, JH; Sangalang, RP; Uylangco, CV, 1985) |
| "The nutrition of a group of Nigerian children who received weekly chemoprophylaxis with chloroquine during their first one or two years of life was compared with the nutrition of a group of children exposed frequently to malaria." | 5.05 | Malaria chemoprophylaxis with chloroquine in young Nigerian children. III. Its effect on nutrition. ( Bradley, AK; Bradley-Moore, AM; Gilles, HM; Greenwood, BM; Kirkwood, BR, 1985) |
| "Two field trials to detect chloroquine-resistant malaria were conducted according to WHO recommendations in a malaria free area near Rangoon." | 5.04 | Chloroquine-resistant malaria in Burma. ( Hlaing, N; Htun Nyun, R; Kyi, KK; Myint, T; Tin, F; U, T, 1975) |
| "A trial of suppression of malaria by administration of combined sulphadoxine-pyrimethamine tablets every 28 days was undertaken in West Malaysia during 1972." | 5.04 | Suppression of malaria with monthly administration of combined sulphadoxine and pyrimethamine. ( Lewis, AN; Ponnampalam, JT, 1975) |
| "Amodiaquine cured 38% (13/34) of patients with falciparum malaria in Southeast Thailand." | 5.04 | Amodiaquine resistant falciparum malaria in Thailand. ( Hall, AP; Kosakal, S; Pearlman, EJ; Phintuyothin, P; Segal, HE, 1975) |
| "Chloroquine (CQ) is an antimalarial drug that elicits severe pruritus in black Africans with malaria fever." | 5.01 | Itching, chloroquine, and malaria: a review of recent molecular and neuroscience advances and their contribution to mechanistic understanding and therapeutics of chronic non-histaminergic pruritus. ( Ajayi, AAL, 2019) |
| "Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure')." | 4.98 | Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. ( Ashley, EA; Recht, J; White, NJ, 2018) |
| " Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), rheumatological (systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, Sjögren's syndrome), and other immunological diseases." | 4.98 | Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review. ( Koudriavtseva, T; Plantone, D, 2018) |
| " We describe recent successes using this technique, including a case where digestomics provided the link between hemoglobin digestion by the malaria parasite and the world-wide distribution of chloroquine resistance." | 4.95 | Digestomics: an emerging strategy for comprehensive analysis of protein catabolism. ( Bingeman, TS; Lewis, IA; Perlman, DH; Storey, DG, 2017) |
| "Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing history as potent antimalarial agents." | 4.91 | Quinoline-based antimalarial hybrid compounds. ( D'hooghe, M; Vandekerckhove, S, 2015) |
| " Chemopreventive strategies have been increasingly deployed in Africa, notably intermittent sulfadoxine-pyrimethamine treatment in pregnancy, and monthly amodiaquine-sulfadoxine-pyrimethamine during the rainy season months in children aged between 3 months and 5 years across the sub-Sahel." | 4.90 | Malaria. ( Dondorp, AM; Faiz, MA; Hien, TT; Mokuolu, OA; Pukrittayakamee, S; White, NJ, 2014) |
| " It is known that the once best antimalarial drug, chloroquine, exerted its effect through interference with the process of hemozoin formation." | 4.90 | Malarial hemozoin: from target to tool. ( Coronado, LM; Nadovich, CT; Spadafora, C, 2014) |
| "For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment." | 4.89 | Chloroquine: modes of action of an undervalued drug. ( Costa, FT; Lopes, SC; Thomé, R; Verinaud, L, 2013) |
| " knowlesi was again brought to the attention of the medical community when in 2004, Balbir Singh and his co-workers reported that about 58% of malaria cases observed in the Kapit district of the Malaysian Borneo were actually caused by P." | 4.89 | Plasmodium knowlesi: the emerging zoonotic malaria parasite. ( Antinori, S; Corbellino, M; Galimberti, L; Milazzo, L, 2013) |
| "Coartem(®), the combination of artemether (an artemisinin derivative) and lumefantrine, has been adopted as the first-line treatment for uncomplicated malaria in many countries." | 4.88 | Update on the in vivo tolerance and in vitro reduced susceptibility to the antimalarial lumefantrine. ( Al-Thukair, A; Nzila, A; Ohuma, E; Okombo, J, 2012) |
| "The antimalarial drugs chloroquine (CQ) and hydroxychloroquine (HCQ) have been used for decades to treat rheumatic diseases." | 4.87 | Ocular toxicity in children exposed in utero to antimalarial drugs: review of the literature. ( Koren, G; Osadchy, A; Ratnapalan, T, 2011) |
| "Plasmodium falciparum resistance to chloroquine and sulphadoxine-pyrimethamine has led to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of treatment against malaria." | 4.85 | Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. ( Eastman, RT; Fidock, DA, 2009) |
| "Chloroquine (CHQ) is a cheap, relatively well tolerated drug initially developed for the treatment of malaria in the 1930s." | 4.84 | Chloroquine: novel uses & manifestations. ( Cooper, RG; Magwere, T, 2008) |
| "To assess the relationship between the genetic and phenotypic factors linked to the cytochrome P-450 enzyme system and the response to the antimalarial drugs chloroquine, amodiaquine, mefloquine, and proguanil, as well as to determine how certain biological and social factors of the host influence the behavior of this enzymatic complex." | 4.83 | [Cytochrome P-450 and the response to antimalarial drugs]. ( Carmona-Fonseca, J; Guzmán, V, 2006) |
| " military aviators are currently restricted to the use of chloroquine or doxycycline for malaria prophylaxis." | 4.82 | Military aviators, special operations forces, and causal malaria prophylaxis. ( Chambers, JA, 2003) |
| "Drug resistance is one of the major factors contributing to the resurgence of malaria, especially resistance to the most affordable drugs such as chloroquine and Fansidar, a combination drug of pyrimethamine and sulfadoxine." | 4.82 | Genetic and biochemical aspects of drug resistance in malaria parasites. ( Hayton, K; Su, XZ, 2004) |
| "Chloroquine (CQ) has been the front line antimalarial drug due to its efficacy, low cost and scanty side effects, until resistance has evolved." | 4.82 | Should chloroquine be laid to rest? ( Ginsburg, H, 2005) |
| "Recent publication have provided strong evidence that activity and cellular uptake of 4-aminoquinoline antimalarials depends on vacuolar haemoglobin degradation and that haematin is the drug target." | 4.81 | Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials. ( Egan, TJ, 2001) |
| "The development of chloroquine as an antimalarial drug and the subsequent evolution of drug-resistant Plasmodium strains had major impacts on global public health in the 20th century." | 4.81 | Chloroquine-resistant malaria. ( Plowe, CV; Wellems, TE, 2001) |
| "Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever." | 4.81 | Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2001) |
| "Chloroquine is a drug with over 60 years of safe clinical use in the treatment of malaria." | 4.81 | [Chloroquine--miscellaneous properties of the antimalarial drug]. ( Jarzyna, R, 2002) |
| "The malarial parasite manifests unique features of heme metabolism." | 4.80 | Heme metabolism of Plasmodium is a major antimalarial target. ( Padmanaban, G; Rangarajan, PN, 2000) |
| "A meta-analysis study evaluating the efficacy and safety of chloroquine and alternative antimalarial drugs used in six African countries including Ethiopia, Kenya, Uganda, Cote D'Ivoire, Gambia and Nigeria is presented." | 4.80 | Comparative efficacy and safety of chloroquine and alternative antimalarial drugs: a meta-analysis from six African countries. ( Makonnen, E; Mengesha, T, 1999) |
| "Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever." | 4.80 | Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2000) |
| "Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy." | 4.79 | The safety of antimalarial drugs in pregnancy. ( Phillips-Howard, PA; Wood, D, 1996) |
| "Chloroquine maculopathy is a major complication observed during prophylactic treatment of malaria." | 4.79 | [Chloroquine maculopathy and prevention of malaria]. ( Balo, KP; Mensah, A; Mihluedo, H, 1996) |
| "Recent studies on the pharmacokinetics of parenteral chloroquine and quinine have resulted in safer regimens for the treatment of severe falciparum malaria." | 4.78 | Therapeutics review: the use of parenteral drugs for falciparum malaria. ( Davidson, RN; Houston, S; Stein, CM, 1990) |
| "The mechanisms whereby the intrinsic pruritogenic effect of chloroquine (a property also encountered among some other 4-amino-quinolines including amodiaquine) becomes aggravated during paroxysmal malarial suppressive chemotherapy with the drug form the basis of this paper." | 4.77 | Mechanisms of enhanced pruritogenicity of chloroquine among patients with malaria: a review. ( Osifo, NG, 1989) |
| "Spreading from 2 countries in 1978 to at least 29 in 1988, chloroquine-resistant Plasmodium falciparum malaria has become a significant concern for travelers to Africa." | 4.77 | The spread of chloroquine-resistant malaria in Africa. Implications for travelers. ( Bernard, KW; Moran, JS, 1989) |
| "A review of all available evidence supports the hypothesis that FP is the receptor for chloroquine and mediator of its antimalarial activity." | 4.77 | Ferriprotoporphyrin IX: role in chloroquine susceptibility and resistance in malaria. ( Fitch, CD, 1989) |
| "We report a case of congenital malaria due to a chloroquine-resistant strain of Plasmodium falciparum acquired in Mali." | 4.77 | [Malaria and pregnancy. Report of a case of congenital Plasmodium falciparum malaria]. ( Chabasse, D; de Gentile, L; Larget-Piet, L; Ligny, C; Minckes, O; Pineau, P, 1989) |
| "The widespread emergence of chloroquine-resistant Plasmodium falciparum led to the formulation of an effective, fixed combination of two antimalarial agents, pyrimethamine and the long-acting sulfonamide sulfadoxine, for prophylaxis and treatment." | 4.77 | Use of pyrimethamine-sulfadoxine (Fansidar) in prophylaxis against chloroquine-resistant Plasmodium falciparum and Pneumocystis carinii. ( Hewlett, EL; Pearson, RD, 1987) |
| "At least four doses of quinine followed by a single dose of mefloquine or by a single dose of sulfadoxine-pyrimethamine are two highly effective regimens for chloroquine-resistant falciparum malaria." | 4.75 | The treatment of malaria. ( Hall, AP, 1976) |
| "The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are still commonly used for malaria treatment, either alone (CQ) or in combination with artemisinin derivatives." | 4.31 | Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities. ( Basilico, N; D'Alessandro, S; Dondio, G; Misiano, P; Nasser, S; Nosten, F; Parapini, S; Rénia, L; Romeo, S; Russell, BM; Sparatore, A; Suwanarusk, R; Taramelli, D; Vivas, L; Yardley, V, 2023) |
| "Pfcrt gene has been associated with chloroquine resistance and the pfmdr1 gene can alter malaria parasite susceptibility to lumefantrine, mefloquine, and chloroquine." | 4.31 | Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia. ( Amambua-Ngwa, A; Dugassa, S; Golassa, L; Jawara, A; Oboh, M; Oriero, E; Tadele, G, 2023) |
| "Malaria parasites generate toxic heme during hemoglobin digestion, which is neutralized by crystallizing into inert hemozoin (β-hematin)." | 4.31 | ( Makde, RD; Singh, R; Srihari, V, 2023) |
| "The efficacy of chloroquine treatment for vivax malaria has been rarely evaluated due to a lack of an appropriate testing method." | 4.31 | Molecular surveillance of chloroquine resistance in Plasmodium vivax isolates from malaria cases in Yunnan Province of China using pvcrt-o gene polymorphisms. ( Chen, M; Deng, Y; Ding, H; Dong, Y; Lin, Y; Liu, L; Liu, Y; Wu, J; Xu, Y; Zhang, C, 2023) |
| "The online and command line versions of Malaria-Profiler detect ~ 250 markers from genome sequences covering Plasmodium speciation, likely geographical source, and resistance to chloroquine, sulfadoxine-pyrimethamine (SP), and other anti-malarial drugs for P." | 4.31 | Rapid profiling of Plasmodium parasites from genome sequences to assist malaria control. ( Beshir, KB; Binh, NTH; Bousema, T; Campino, S; Clark, TG; Di Santi, SM; Dombrowski, JG; Gitaka, J; Manko, E; Ngoc, NTH; Nolder, D; Phelan, JE; Sutherland, CJ; Thieu, NQ; Thorpe, J; Turkiewicz, A; van de Vegte-Bolmer, M; Vanheer, LN, 2023) |
| "The study concluded that the water extract with higher antimalarial activity could be optimized for chloroquine-resistant malaria and can thus facilitate the production of liquid and solid dosage forms." | 4.12 | Comparative in vivo antimalarial activities of aqueous and methanol extracts of MAMA powder - A herbal antimalarial preparation. ( Adepiti, AO; Adeyoju, EO; Ajayi, CO; Elujoba, AA, 2022) |
| "A series of heterocyclic chloroquine hybrids containing either a β-phenethylamine fragment or a 2-aminoindane moiety were synthesized and screened in vitro as inhibitors of β-hematin formation and in vivo for their antimalarial activity against chloroquine-sensitive strains of Plasmodium berghei ANKA." | 4.12 | Synthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity. ( Ángel, JE; Charris, JE; Fernandez-Moreira, E; Mijares, MR; Ramírez, H; Rodrigues, JR, 2022) |
| "Using data from a trial of medication to prevent malaria in pregnancy that randomized 600 women to receive chloroquine or sulfadoxine-pyrimethamine during pregnancy, we conducted a NCC study assessing the role of prospectively collected AEs, as exposure of interest, on treatment non-adherence and study non-completion." | 4.12 | Effect of adverse events on non-adherence and study non-completion in malaria chemoprevention during pregnancy trial: A nested case control study. ( Chirwa, T; Divala, T; Kazembe, L; Laufer, MK; Mathanga, D; Mukaka, M; Patson, N; Peterson, I, 2022) |
| "Artesunate-amodiaquine (ASAQ) and Artemether-lumefantrine (AL) are the recommended treatment for uncomplicated Plasmodium falciparum malaria in Liberia." | 4.12 | Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers. ( Asinya, M; Jeuronlon, MK; Kamara, P; Koko, VS; Kollie, A; Ma, L; Menard, D; Nyansaiye, P; Parwon, S; Pratt, OJ; Ringwald, P; Taweh, F; Tehmeh, L; Vonhm, B; Warsame, M, 2022) |
| "We developed a novel clickable, photo-affinity chloroquine analog probe (CQP) which retains the antimalarial activity in the nanomole range, and identified a total of 40 proteins that specifically interacted and photo-crosslinked with CQP which was inhibited in the presence of excess CQ." | 4.12 | Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA. ( Chen, JY; Dai, LY; Gao, P; Gu, LW; Guo, QY; Li, ZJ; Liu, YQ; Meng, YQ; Shi, QL; Tang, H; Wang, JG; Xia, F; Xiao, W; Xu, CC; Yang, F; Zhang, JZ; Zhang, Q; Zhang, Y; Zheng, LH; Zhu, YP, 2022) |
| " The mice were infected with standard inoculum of the strain NK65 Plasmodium berghei (chloroquine sensitive) and the percentage parasitemia suppression were evaluated." | 4.12 | Effect of black seeds (Nigella sativa) on inflammatory and immunomodulatory markers in Plasmodium berghei-infected mice. ( Ademosun, AO; Oboh, G; Ojueromi, OO, 2022) |
| "The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic development of the human malaria parasite Plasmodium falciparum." | 4.12 | The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum. ( Barrett, MP; Lanzer, M; Mandel, L; Manson, EDT; Moliner Cubel, S; Sanchez, CP; Weidt, SK, 2022) |
| "Until late 2015, Botswana recommended preventive treatment for pregnant women in malarial regions with chloroquine and proguanil (CP)." | 4.12 | Impact of prophylactic antimalarials in pregnant women living with Human Immunodeficiency Virus on birth outcomes in Botswana. ( Diseko, M; Lockman, S; Mabuta, J; Makhema, J; Mayondi, G; Melton, ML; Mmalane, M; Olaleye, OA; Shapiro, RL; Zash, R, 2022) |
| " Chloroquine (CQ) is a low-cost antimalarial used worldwide for the treatment of Plasmodium vivax malaria." | 4.12 | Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues. ( Annunciato, Y; Caroline C Aguiar, A; Cortopassi, WA; Dos Santos Ferreira, A; Garcia Teles, CB; Gazarini, ML; Guido, RVC; Gunderson, E; Jacobson, MP; Krettli, AU; Meneghetti, MR; Pereira, DB; Pimentel, AS; Ramamoorthi, R; Silva, AES, 2022) |
| "Chloroquine (CQ) has been the main treatment for malaria in regions where there are no resistant strains." | 4.02 | In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization. ( Abramo, C; David da Silva, A; de Almeida Pimentel, G; de Pilla Varotti, F; Glanzmann, N; Gualberto Pereira, HM; Karine da Costa Nunes, I; Marinho, JA; Martins Guimarães, DS; Navarro, M, 2021) |
| "The FDA approved drug Dronabinol was identified in a previous study applying virtual screening using the haemozoin crystal as a target against malaria parasites." | 4.02 | THC shows activity against cultured Plasmodium falciparum. ( Combrinck, JM; de Sousa, ACC; Egan, TJ; Maepa, K, 2021) |
| "Based on reports of parasite resistance and on World Health Organization recommendation, chloroquine was replaced with the artemisinin-based combination therapies (ACTs) as the first choice of drugs for the treatment of uncomplicated malaria." | 4.02 | Treatment of COVID-19 with Chloroquine: Implication for Malaria Chemotherapy Using ACTs in Disease Endemic Countries. ( Duah-Quashie, NO; Quashie, NB, 2021) |
| " The inhibition of heme detoxification test as one of the antimalarial mechanisms was carried out using the Basilico method." | 4.02 | Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification. ( Arwati, H; Basuki, DR; Ekasari, W; Wahyuni, TS, 2021) |
| "The quest for the development of a novel antimalarial drug informed the decision to subject phytol to in vivo trials following a demonstration of therapeutic potential against chloroquine sensitive strain of Plasmodium falciparum under in vitro condition." | 4.02 | Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei. ( Abubakar, MS; Adamu, A; Ibrahim, MA; Salman, AA; Usman, FI; Usman, MA, 2021) |
| "This study aimed to analyze the interaction of primaquine (PQ), chloroquine (CQ), and liposomes to support the design of optimal liposomal delivery for hepatic stage malaria infectious disease." | 4.02 | Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes. ( Ekowati, J; Hendradi, E; Miatmoko, A; Nehru, NF; Nurjannah, I; Rosita, N; Sari, R, 2021) |
| " The antimalarial activity was evaluated using chloroquine-sensitive Plasmodium berghei on swiss albino mice, in a chemosuppressive test, at 150, 350, and 700 mg/kg, p." | 4.02 | Developmental stages influence in vivo antimalarial activity of aerial part extracts of Schkuhria pinnata. ( Adriko, J; Ajayi, CO; Kagoro, GR; Nuwagira, C; Ogwang, PE; Olet, EA; Peter, EL; Tolo, CU, 2021) |
| "Probiotic in combination with chloroquine showed complete suppression in parasitemia rate." | 4.02 | Evaluation of the effect of probiotic as add-on therapy with conventional therapy and alone in malaria induced mice. ( Bhatia, A; Mahajan, E; Medhi, B; Sehgal, R; Sinha, S, 2021) |
| "Hence, this study was therefore aimed at evaluating the antimalarial activity of a probiotic bacterium Lactobacillus sakei isolated from traditionally fermented milk in mice infected with chloroquine sensitive Plasmodium berghei ANKA." | 4.02 | In vivo antimalarial activity of a probiotic bacterium Lactobacillus sakei isolated from traditionally fermented milk in BALB/c mice infected with Plasmodium berghei ANKA. ( Achidi, EA; Bila, RB; Feugaing Sofeu, DD; Ivo, EP; Taiwe, GS; Tatsinkou Fossi, B; Toukam, LL, 2021) |
| " Two of the molecules which were designed based on the results of this QSAR study, had shown good percentage of parasitemia against both chloroquine sensitive (3D7) and chloroquine resistant (Dd2) strains of Plasmodium falciparum respectively." | 3.96 | Discovery of potential 1,3,5-Triazine compounds against strains of Plasmodium falciparum using supervised machine learning models. ( Ghosh, SK; Ginjupalli, MC; K, KR; Kalita, JM; Sahu, S, 2020) |
| "Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment." | 3.96 | Concentration-dependent mortality of chloroquine in overdose. ( Baud, FJ; Clemessy, JL; Hoglund, RM; Megarbane, B; Tarning, J; Watson, JA; White, NJ, 2020) |
| "We reviewed the clinical efficacy of chloroquine for Plasmodium vivax malaria, the changing trend of parasite clearance time, and fever clearance time during 2000-2016 in South Korea." | 3.96 | Increasing Malaria Parasite Clearance Time after Chloroquine Therapy, South Korea, 2000-2016. ( Cho, SH; Kwak, YG; Lee, KS; Lee, SE; Park, SY; Park, Y; Park, YS; Shin, HI; Song, JE; Yeom, JS, 2020) |
| "A tremendous level of success has been achieved since the introduction of chloroquine and the combination of amodiaquine and artemisinin for the treatment of both complicated and uncomplicated malaria infections in sub-Saharan Africa." | 3.96 | Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria. ( Adeniyi, OM; Ajibaye, O; Aremu, OI; Asogwa, N; Babamale, OA; Fakayode, O; Fatoba, IM; Iyiola, OA; Omotesho, OB; Opeyemi, OA; Salawu, KM; Shittu, O, 2020) |
| "Treatment Failure with chloroquine is one of the challenges that faced the dedicated efforts to eradicate malaria This study aims at investigating the impact of treatment failure with chloroquine on the progression of the disease-induced histo-pathogenic and immunogenic outcomes." | 3.96 | Progression of malaria induced pathogenicity during chloroquine therapy. ( Abd Majid, R; Abd Rachman-Isnadi, MF; Basir, R; Bello, RO; Chin, VK; Noor, SM; Sidek, HM; Zaid, OI, 2020) |
| "Phenyl- and bioisosteric ferrocenyl-derived aminoquinoline-benzimidazole hybrid compounds were synthesised and evaluated for their in vitro antiplasmodial activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human malaria parasite, Plasmodium falciparum." | 3.91 | Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights. ( Baartzes, N; Chibale, K; Seldon, R; Smith, GS; Stringer, T; Taylor, D; Warner, DF; Wittlin, S, 2019) |
| "Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug resistance confronts this regimen and threatens malaria control programs." | 3.91 | Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross. ( Abebe, Y; Bailey, JA; Brazeau, NF; Chakravarty, S; DeConti, DK; Dinglasan, RR; Eastman, RT; Engels, T; Fasinu, PS; Fay, MP; Gibson, TJ; Gwadz, RW; Han, PK; Hoffman, SL; James, ER; Juliano, JJ; Kaslow, SR; Kessler, EG; Kim, A; Kite, WA; Krause, MA; Lambert, LE; Melendez-Muniz, V; Moraes Barros, RR; Mu, J; Orr-Gonzalez, S; Parobek, CM; Sá, JM; Salzman, RE; Serre, D; Sim, BKL; Tao, D; Thomas, ML; Velmurugan, S; Walker, L; Wellems, TE, 2019) |
| "This study aimed to investigate the in vitro anti-malarial activity of methanol and dichloromethane extracts of the two plants against chloroquine sensitive (D6) and chloroquine resistant (Dd2) strains of Plasmodium falciparum." | 3.91 | In vitro and in vivo studies on anti-malarial activity of Commiphora africana and Dichrostachys cinerea used by the Maasai in Arusha region, Tanzania. ( Assob, JN; Efange, N; Kitau, J; Kweyamba, PA; Nyindo, M; Zofou, D, 2019) |
| "Balb/C mice infected by Plasmodium chabaudi were treated with captopril, an angiotensin I-converting enzyme (ACE) inhibitor, used alone or in association with the anti-malarial chloroquine in order to study the effect of ACE inhibition on mice survival and the activation of liver responses involving B1R and B2R signaling pathways." | 3.91 | Malaria infection promotes a selective expression of kinin receptors in murine liver. ( Barros, NMT; Carmona, AK; Carvalho, CPF; Dantas, EO; Gazarini, ML; Martinez, C; Martins-Silva, L; Melo, PMS; Nagaoka, MR; Pesquero, JB; Ventura, PDS, 2019) |
| " Two days after initiation of oral chloroquine treatment, an acute respiratory distress syndrome was diagnosed through chest X-ray and chest CT scan with intravenous contrast." | 3.88 | Severe Plasmodium ovale malaria complicated by acute respiratory distress syndrome in a young Caucasian man. ( Corpolongo, A; D'Abramo, A; Gebremeskel Tekle, S; Iannetta, M; Nicastri, E; Oliva, A; Paglia, MG; Scorzolini, L, 2018) |
| "Antimalarial interventions mostly rely upon drugs, as chloroquine." | 3.88 | In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06. ( Areas, ALL; Bozza, PT; Costa, NF; da Silva Frutuoso, V; de Castro-Faria-Neto, HC; de Lima Ferreira, M; de Souza, MVN; Douradinha, B; Kaiser, CR; Pais, KC; Pereira, MF; Reis, PA; Zalis, MG, 2018) |
| "A series of 4-anilinoquinoline triazine derivatives were designed, synthesized and screened for in vivo antimalarial activity against a chloroquine-sensitive strain of Plasmodium berghei." | 3.85 | Docking, synthesis and antimalarial activity of novel 4-anilinoquinoline derivatives. ( Mahajan, S; Vijayaraghavan, S, 2017) |
| "Epoxyazadiradione (1), a major compound derived from Neem oil, showed modest anti-plasmodial activity against CQ-resistant and CQ-sensitive strains of the most virulent human malaria parasite P." | 3.85 | Synthesis and evaluation of anti-plasmodial and cytotoxic activities of epoxyazadiradione derivatives. ( Allanki, AD; Ashok Yadav, P; Jain, N; Pavan Kumar, C; Sijwali, PS; Siva, B; Suresh Babu, K; Veerabhadra Rao, A, 2017) |
| "We describe the first systematic study of antimalarial 1,2,4-trioxolanes bearing a substitution pattern regioisomeric to that of arterolane." | 3.85 | Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. ( Blank, BR; Gut, J; Renslo, AR; Rosenthal, PJ, 2017) |
| "The trans platinum-chloroquine diphosphate dichloride (PtCQ) is a new type of antimalarial drug used to fight parasites resistant to traditional drugs." | 3.85 | Effective-Loading of Platinum-Chloroquine into PEGylated Neutral and Cationic Liposomes as a Drug Delivery System for Resistant Malaria Parasites. ( Ibrahim, S; Ozeki, T; Tagami, T, 2017) |
| "The present study was aimed at determining and comparing the effects of Artecxin (ART), P - Alaxin (P-ALA), Lonart (LON) and Chloroquine (CQ) on oxidative stress parameters and mitochondrial membrane composition in the course of malaria infection." | 3.85 | Assessment of liver antioxidant status and mitochondrial membrane composition of Plasmodium berghei-infected mice treated with selected antimalarials. ( Adisa, RA; Sulaimon, LA, 2017) |
| "The Wolrd Health Organization (WHO) encourages all countries to investigate antimalarial drug substances derived from herbal sources with the slogan "Hunt of the Next Artemisinin" due to the emergence of resistant strains of Plasmodium species to artemisinin." | 3.85 | In vivo and in vitro Models for Scanning Drug Substances in Malaria: Prestudy. ( Çavuş, İ; Kaya, T; Nuraydın, A; Özbilgin, A, 2017) |
| " A fixed ratio method based on the SYBR Green I fluorescence-based assay was used to build isobolograms from a combination of cryptolepine with four standard anti-malarial drugs in vitro using the chloroquine sensitive strain 3D7." | 3.85 | In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine. ( Annan, K; Ansah, C; Forkuo, AD; Gyan, B; Mancama, D; Mensah, KB; Theron, A; Wright, CW, 2017) |
| "New treatments against malaria (artemisinin-based combination therapies, ACT) resulted in profound changes in the therapeutic behaviours in Africa." | 3.85 | [Practices of caregivers and national recommendations for treatment of malaria in Benin in 2009]. ( Bruneton, C; Guévart, E; Robin, S, 2017) |
| "Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyrazine series led to the identification of highly potent compounds against the blood life-cycle stage of the human malaria parasite Plasmodium falciparum." | 3.83 | Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle. ( Angulo-Barturen, I; Antonova-Koch, Y; Bashyam, S; Birkholtz, LM; Botha, ME; Charman, SA; Chibale, K; Ferrer, S; Gonzàlez Cabrera, D; Han, Z; Jiménez-Díaz, MB; Lawrence, N; Le Manach, C; Martínez, MS; Meister, S; Nchinda, AT; Nondaba, SH; Paquet, T; Reader, J; Street, LJ; Taylor, D; Waterson, D; White, KL; Winzeler, EA; Wittlin, S; Witty, MJ; Younis, Y; Zabiulla, M, 2016) |
| "To understand the endemic situation of chloroquine-resistant falciparum malaria in Yunnan Province by analyzing the polymorphism of the 72-76 amino-acid coding sequence within exon 2 region of Plasmodium falciparum chloroquine resistant transporter (Pfcrt) gene （referred to as the 72-76 coding region） in malaria patients." | 3.83 | [Polymorphism of 72-76 Coding Sequence within Exon 2 Region of Pfcrt in Yunnan Province]. ( Chen, MN; Deng, Y; Dong, Y; Mao, XH; Xu, YC; Zhu, YJ, 2016) |
| "Co-administration of amodiaquine with MAMA decoction (MD), an herbal antimalarial drug comprising the leaves of Mangifera indica L." | 3.83 | Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model. ( Adepiti, AO; Bolaji, OO; Elujoba, AA, 2016) |
| "In 1993, Malawi changed its first-line anti-malarial treatment for uncomplicated malaria from chloroquine to sulfadoxine-pyrimethamine (SP), and in 2007, it changed from SP to lumefantrine-artemether." | 3.83 | Malaria research and its influence on anti-malarial drug policy in Malawi: a case study. ( de Jager, C; Hongoro, C; Longwe, H; Mutero, CM; Mwendera, C; Phiri, K, 2016) |
| "Oral Asiatic acid administration influenced %parasitaemia suppression, ameliorated malarial anaemia and increased biophysical properties on infected animals." | 3.83 | Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P. berghei infected Sprague-Dawley male rats. ( Mabandla, MV; Mavondo, GA; Mkhwananzi, BN; Musabayane, CT, 2016) |
| "Faced with intense levels of chloroquine (CQ) resistance in Plasmodium falciparum malaria, Rwanda replaced CQ with amodiaquine (AQ)+sulfadoxine-pyrimethamine (SP) in 2001, and subsequently with artemether-lumefantrine (AL) in 2006, as first-line treatments for uncomplicated malaria." | 3.83 | Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda. ( Grobusch, MP; Hakizimana, E; Kateera, F; Kumar, N; Mens, PF; Mutesa, L; Nsobya, SL; Tukwasibwe, S; van Vugt, M, 2016) |
| "The present study investigated the effects of transdermally delivered oleanolic acid (OA) monotherapy and in combination with chloroquine (CHQ) on malaria parasites and glucose homeostasis of P." | 3.83 | The Effects of Transdermally Delivered Oleanolic Acid on Malaria Parasites and Blood Glucose Homeostasis in P. berghei-Infected Male Sprague-Dawley Rats. ( Mabandla, MV; Musabayane, CT; Sibiya, HP, 2016) |
| "A series of novel aminoalkylated quercetin analogs, prepared via the Mannich reaction of various primary and secondary amines with formaldehyde, were tested for antimalarial activity." | 3.81 | The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs. ( Akoto, M; Avery, VM; Duffy, S; Hagen, TJ; Helgren, TR; Igbinoba, O; Lee, P; Sciotti, RJ, 2015) |
| "Chloroquine (CQ) has been used as first line malaria therapeutic drug for decades." | 3.81 | Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives. ( Caridha, D; Gerena, L; Korotchenko, V; Kreishman-Deitrick, M; Li, Q; Lin, AJ; Sathunuru, R; Smith, PL, 2015) |
| " The best inhibitors were tested in vivo as potential antimalarials in mice infected with Plasmodium berghei ANKA chloroquine susceptible strain, three of them (11b, 11d and 11h) displayed an antimalarial activity comparable to that of chloroquine." | 3.81 | Synthesis, β-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei. ( Acosta, ME; Charris, JE; Gamboa, N; López, SE; Romero, AH; Salazar, J, 2015) |
| "A novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resistant) and NF54 (sensitive) strains of the malaria parasite Plasmodium falciparum." | 3.81 | Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. ( Chibale, K; Egan, TJ; Jurva, U; Masimirembwa, CM; Njoroge, M; Ongarora, DS; Strydom, N; Wicht, K; Wiesner, L; Wittlin, S, 2015) |
| "42), showing antimalarial activity against drug-resistant and sensitive strains (EC50 values ∼ 3 μM), selectivity for malaria parasite and no cross-resistance with chloroquine, thus representing a potential new chemotype for further optimization towards novel and affordable antimalarial drugs." | 3.81 | Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype. ( Coelho, L; Lukens, AK; Mazitschek, R; Moreira, R; Nogueira, F; Paulo, A; Santos, SA; Wirth, DF, 2015) |
| "A new series of chloroquinoline-4H-chromene conjugates incorporating piperizine or azipane tethers were synthesized and their anti-malarial activity were evaluated against two Plasmodium falciparum strains namely 3D7 chloroquine sensitive (CQS) and K1 chloroquine resistant (CQR)." | 3.81 | Synthesis, in vitro and in silico antimalarial activity of 7-chloroquinoline and 4H-chromene conjugates. ( Krishna, R; Manhas, A; Muthukumaran, J; Parthiban, A; Rao, HS; Srivastava, K, 2015) |
| " In our study, chitosan-tripolyphosphate (CS-TPP) particles was conjugated with an undervalued antimalarial drug, chloroquine to find out the proficiency against ROS mediated caspase activation and apoptosis in liver during Plasmodium berghei NK65 infection." | 3.81 | Chitosan conjugated chloroquine: proficient to protect the induction of liver apoptosis during malaria. ( Chattopadhyay, S; Chowdhuri, AR; Das, S; Dash, SK; Majumdar, S; Roy, S; Sahu, SK; Tripathy, S, 2015) |
| "Protection against malaria in humans can be achieved by repeated exposure to infected mosquito bites during prophylactic chloroquine treatment (chemoprophylaxis and sporozoites (CPS))." | 3.81 | Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization. ( Jarra, W; Langhorne, J; Lévy, P; Nahrendorf, W; Sauerwein, RW; Spence, PJ; Tumwine, I, 2015) |
| " The compounds were evaluated for their in vivo antimalarial activity against Plasmodium berghei infected mice and the most active derivatives were further examined for their in vitro antimalarial activity against chloroquine resistant (RKL9) strain of Plasmodium falciparum." | 3.81 | New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. ( Abd El Razik, HA; Bekhit, AA; Bekhit, Ael-D; El-Agroudy, EJ; El-Miligy, MM; Hassan, AM, 2015) |
| "Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria." | 3.81 | Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria. ( Bijker, EM; Cockburn, I; Nganou-Makamdop, K; Sauerwein, RW; van Gemert, GJ; Zavala, F, 2015) |
| "Chloroquine (CQ) has been the mainstay of malaria treatment for more than 60 years." | 3.81 | Contrasting ex vivo efficacies of "reversed chloroquine" compounds in chloroquine-resistant Plasmodium falciparum and P. vivax isolates. ( Burgess, SJ; Chalfein, F; Handayuni, I; Kenangalem, E; Marfurt, J; Noviyanti, R; Peyton, DH; Poespoprodjo, JR; Price, RN; Sebayang, BF; Wirjanata, G, 2015) |
| "In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line treatment of Plasmodium falciparum infections has typically led to the restoration of CQ susceptibility through the reexpansion of the wild-type (WT) allele K76 of the chloroquine resistance transporter gene (pfcrt) at the expense of less fit mutant alleles carrying the CQ resistance (CQR) marker K76T." | 3.81 | Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt. ( Casteras, J; Dhingra, SK; Fidock, DA; Gabryszewski, SJ; Legrand, E; Moss, EL; Musset, L; Neafsey, DE; Pelleau, S; Volkman, SK; Volney, B; Wirth, DF, 2015) |
| "The antimalarial activity and lipid profiles of Methyl Jasmonate (MJ) were investigated against established malaria infection in vivo using BALB/c mice." | 3.81 | Potential antimalarial activity of Methyl Jasmonate and its effect on lipid profiles in Plasmodium Berghei infected mice. ( Ademowo, OG; Emikpe, B; Falade, CO; Kosoko, AM; Oyinloye, OE, 2015) |
| "The control of malaria has been complicated by increased resistance of the malaria parasite to existing antimalarials such as chloroquine (CQ)." | 3.80 | Pentacycloundecylamines and conjugates thereof as chemosensitizers and reversed chloroquine agents. ( Fortuin, EE; Joubert, J; Malan, SF; Smith, PJ; Taylor, D, 2014) |
| "Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria." | 3.80 | Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria. ( du Plessis, LH; Helena, C; Kotzé, AF; van Huysteen, E; Wiesner, L, 2014) |
| " We tested this hypothesis with a clinically derived chloroquine-resistant (CQ(r)) malaria parasite and with parasites derived by in vitro selection with Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors." | 3.80 | Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance. ( Booker, ML; Hartl, DL; Heidebrecht, R; Javier Gamo, F; Lafuente-Monasterio, MJ; Lukens, AK; Ross, LS; Wiegand, RC; Wirth, DF, 2014) |
| "Plumbagin exhibited promising antimalarial activity with in vitro IC50 (concentration that inhibits parasite growth to 50%) against 3D7 chloroquine-sensitive P." | 3.80 | Antimalarial activity of plumbagin in vitro and in animal models. ( Chaijaroenkul, W; Karbwang, J; Na-Bangchang, K; Plengsuriyakarn, T; Sumsakul, W; Viyanant, V, 2014) |
| "To investigate the antimalarial potential of kolaviron (KV), a biflavonoid fraction from Garcinia kola seeds, against Plasmodium berghei (P." | 3.80 | Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice. ( Aderemi, K; Ayokulehin, K; Catherine, F; Olusegun, A; Oluwatosin, A; Patricia, O; Tolulope, A, 2014) |
| "Sterile protection against malaria infection can be achieved by the inoculation of intact sporozoites while treating concomitantly with the 4-aminoquinoline chloroquine." | 3.80 | CD8(+) T cells mediate robust stage-specific immunity to P. berghei under chemoprophylaxis and this protective environment is not downregulated by the presence of blood-stage infection. ( Heiss, K; Lewis, MD; Mueller, AK; Pfeil, J, 2014) |
| "Chloroquine (CQ), a cost effective antimalarial drug with a relatively good safety profile and therapeutic index, is no longer used by itself to treat patients with Plasmodium falciparum due to CQ-resistant strains." | 3.80 | Plasmodium vivax and Plasmodium falciparum ex vivo susceptibility to anti-malarials and gene characterization in Rondônia, West Amazon, Brazil. ( Aguiar, AC; Amaral, NS; De Marco, L; Krettli, AU; Pereira, DB, 2014) |
| " Juss (Meliaceae) leaves, plus four new variants of this combination were subjected to three in vivo antimalarial test models using chloroquine-sensitive Plasmodium berghei berghei to determine the most active under each of the test models." | 3.80 | Influence of formulation ratio of the plant components on the antimalarial properties of MAMA decoction. ( Adebajo, AC; Elujoba, AA; Odediran, SA, 2014) |
| "Increased resistance by Plasmodium falciparum parasites led to the withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in Ethiopia." | 3.80 | Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia. ( Aseffa, A; Berhe, N; Clouse, RM; Gebru, T; Medhin, G; Mekonnen, SK; Teklehaymanot, T; Velavan, TP, 2014) |
| "An alternative antimalarial pathway of an 'outdated' drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials." | 3.80 | Validation of a chloroquine-induced cell death mechanism for clinical use against malaria. ( Batty, KT; Ch'ng, JH; Chang, ZW; Chia, WN; Gun, SY; Lee, YQ; Nosten, F; Renia, L; Russell, B; Tan, KS; Wong, LK, 2014) |
| " Radical cure with primaquine was prescribed after the first bout of malaria for 6 patients." | 3.80 | Compliance to recommendations for the management of curative treatment of Plasmodium vivax/ovale infections. ( Bellanger, AP; Chirouze, C; Faucher, JF; Hoen, B; Hustache-Mathieu, L; Shaniya, N, 2014) |
| "Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported." | 3.80 | Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat province, Western Cambodia. ( Amaratunga, C; Anderson, JM; Chuor, CM; Fairhurst, RM; Mao, S; Sreng, S; Suon, S; Tullo, GS, 2014) |
| "Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure." | 3.80 | Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta). ( Gettyacamin, M; Imerbsin, R; Khemawoot, P; Lanteri, C; Nanayakkara, NP; Ohrt, C; Sampath, A; Saunders, D; Siripokasupkul, R; Teja-Isavadharm, P; Tekwani, BL; Vanachayangkul, P; Walker, L, 2014) |
| "Results indicate prominent anti-malarial action of tigecycline in vitro and in vivo in combination with CQ and support further evaluation of tigecycline as a potential combination candidate for treatment of drug-resistant cases of malaria." | 3.80 | In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine. ( Sahu, R; Tekwani, BL; Walker, LA, 2014) |
| "Chloroquine (CQ), a well-known anti-malarial drug, has long been used for the treatment of autoimmune diseases because of its profound immunomodulatory effects." | 3.80 | Early treatment with chloroquine inhibits the immune response against Plasmodium yoelii infection in mice. ( Cao, Y; Chen, G; Du, Y; Feng, Y; Pang, W; Qi, Z; Qin, X; Zhu, X, 2014) |
| "To obtain a high antimalarial activity with neocryptolepine derivatives, modifying and changing the side chains at the C11 position with varying the substituents of an electron-withdrawing or electron-donating nature at the C2 position for a SAR study were executed." | 3.79 | Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines. ( El Sayed, I; Inokuchi, T; Kaiser, M; Lu, WJ; Maeda, T; Mei, ZW; Pang, CQ; Peng, W; Wang, L, 2013) |
| "Due to the widespread prevalence of resistant parasites, chloroquine (CQ) was removed from front-line antimalarial chemotherapy in the 1990s despite its initial promise of disease eradication." | 3.79 | A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. ( Boudhar, A; Bozdech, Z; Ch'ng, JH; Lear, MJ; Mok, S; Nosten, F; Russell, B; Tan, KS, 2013) |
| "The emergence of artemisinin-resistant Plasmodium falciparum malaria in Southeast Asia has reinforced the urgent need to discover novel chemotherapeutic strategies to treat and control malaria." | 3.79 | An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites. ( Amewu, RK; Guedes, RC; Gut, J; Lopes, F; Miranda, D; Moreira, R; Newton, AS; O'Neill, PM; Oliveira, R; Rosenthal, PJ; Srivastava, A; Ward, SA, 2013) |
| "PU-H71 exhibited antimalarial activity in the nanomolar range, displayed synergistic activity with chloroquine in vitro." | 3.79 | A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90). ( Chiosis, G; Crandall, I; Folefoc, A; Pillai, DR; Shahinas, D; Taldone, T, 2013) |
| "Evidence suggests that Plasmodium knowlesi malaria in Sarawak, Malaysian Borneo remains zoonotic, meaning anti-malarial drug resistance is unlikely to have developed in the absence of drug selection pressure." | 3.79 | Susceptibility of human Plasmodium knowlesi infections to anti-malarials. ( Ahmed, MA; Cox-Singh, J; Fatih, FA; Kocken, CH; Krishna, S; Pasini, EM; Siner, A; Singh, B; Staines, HM; Woon, LC, 2013) |
| "Widespread resistance to chloroquine was the mainstay to implement artemisinin-based combination therapy (ACT) in the year 2007 in few malaria endemic states in India including Jharkhand as the first line of treatment for uncomplicated Plasmodium falciparum malaria." | 3.79 | Insights following change in drug policy: a descriptive study for antimalarial prescription practices in children of public sector health facilities in Jharkhand state of India. ( Anvikar, AR; Das, MK; Gupta, R; Mishra, N; Rana, R; Shahi, B; Singh, S; Valecha, N, 2013) |
| "Previously reported studies identified analogues of propafenone that had potent antimalarial activity, reduced cardiac ion channel activity, and properties that suggested the potential for clinical development for malaria." | 3.78 | Lead optimization of antimalarial propafenone analogues. ( Clark, JA; Connelly, MC; Derisi, JL; Furimsky, A; Gow, J; Guiguemde, WA; Guy, RK; Iyer, LV; Kyle, DE; Lemoff, A; Lowes, D; Mirsalis, J; Parman, T; Pradhan, A; Sigal, M; Tang, L; Wilson, E; Zhu, F, 2012) |
| "As part of a research program aimed at discovering new antimalarial leads from Australian macrofungi a unique fungi-derived prefractionated library was screened against a chloroquine-sensitive Plasmodium falciparum line (3D7) using a radiometric growth inhibition assay." | 3.78 | Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold. ( Andrews, KT; Choomuenwai, V; Davis, RA, 2012) |
| "The increasing spread of chloroquine resistant malaria has intensified the search for new antimalarial treatment, especially drugs that can be used in combination." | 3.78 | Interaction between ciprofloxacin and chloroquine in mice infected with chloroquine resistant Plasmodium berghei: interaction between ciprofloxacin and chloroqune. ( Abiodun, OO; Gbotosho, GO; Happi, CT; Oduola, AM; Sowunmi, A; Woranola, O, 2012) |
| " The questionnaire elicited information on their: knowledge about malaria, attitude, chemotherapy and chemoprophylaxis using pyrimethamine, chloroquine proguanil as well as IPTp with sulphadoxine-pyrimethamine (SP)." | 3.78 | Patterns of case management and chemoprevention for malaria-in-pregnancy by public and private sector health providers in Enugu state, Nigeria. ( Onwujekwe, O; Onwujekwe, OC; Shu, E; Soremekun, RO; Uzochukwu, B, 2012) |
| " berghei malaria can successfully be induced in mice by immunization with both radiation attenuated sporozoites (RAS) arresting early during liver stage development, or sporozoites combined with chloroquine chemoprophylaxis (CPS), resulting in complete intra-hepatic parasite development before killing of blood-stages by chloroquine takes place." | 3.78 | Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells. ( Arens, T; Hermsen, CC; Nganou-Makamdop, K; Sauerwein, RW; van Gemert, GJ, 2012) |
| "Chloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or therapeutic index)." | 3.78 | Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites. ( Aguiar, AC; Cortopassi, WA; Figueiredo, FJ; França, TC; Krettli, AU; Meneghetti, MR; Pimentel, AS; Santos, Rde M, 2012) |
| "The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei." | 3.78 | The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. ( Aldana, I; Bertani, S; Deharo, E; Garavito, G; Quiliano, M; Valentin, A, 2012) |
| "In the human malaria parasite Plasmodium falciparum, the major determinant of chloroquine resistance, P." | 3.78 | Tricks in Plasmodium's molecular repertoire--escaping 3'UTR excision-based conditional silencing of the chloroquine resistance transporter gene. ( Ecker, A; Ekland, EH; Fidock, DA; Jayabalasingham, B; Lewis, RE, 2012) |
| "Reports of potential drug-resistant strains of Plasmodium malariae in western Indonesia raise concerns that chloroquine resistance may be emerging in P." | 3.77 | In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. ( Anstey, NM; Chalfein, F; Ebsworth, EP; Kenangalem, E; Marfurt, J; Piera, KA; Prasetyorini, B; Price, RN; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, M, 2011) |
| " In this study, a new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride (1), showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leishmaniasis model." | 3.77 | Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. ( Anklin, C; Bahar, M; Deng, Y; Doskotch, RW; Drew, ME; Gil, RR; He, S; Kinghorn, AD; Navarro-Vázquez, A; Pandharkar, T; Werbovetz, KA; Zhu, X, 2011) |
| " Compounds 1-6, were evaluated for their antimalarial activity against the erythrocytic stages of the Plasmodium falciparum chloroquine-sensitive strain 3D7 and the chloroquine-resistant clone Dd2." | 3.77 | Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections. ( da Cruz, FP; Ferreira, MJ; Lopes, D; Mulhovo, S; Prudêncio, M; Ramalhete, C; Rosário, VE, 2011) |
| "An ethnopharmacological investigation was undertaken on Western Ghats plants traditionally used to treat malaria; 50 plants were very carefully selected from total of 372 plants, and 216 extracts were prepared and tested for in vivo antiplasmodial activity alone and in combination with chloroquine (CQ) against CQ-tolerant Plasmodium berghei (strain NK65)." | 3.77 | Antimalarial activity of traditionally used Western Ghats plants from India and their interactions with chloroquine against chloroquine-tolerant Plasmodium berghei. ( Kadarkari, M; Samy, K, 2011) |
| "Naphthoquine (NQ), as a component of ARCO® which composed of NQ and artemisinin, is a new 4-aminoquinoline antimalarial synthesized by our institute." | 3.77 | Plasmodium berghei K173: selection of resistance to naphthoquine in a mouse model. ( Bei, ZC; Cao, WC; Wang, H; Wang, JY, 2011) |
| "In an attempt to separate the antimalarial activity of tafenoquine (3) from its hemolytic side effects in glucose-6-phosphate dehydrogenase (G6PD) deficiency patients, a series of 5-aryl-8-aminoquinoline derivatives was prepared and assessed for antimalarial activities." | 3.77 | Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives. ( Hudson, TH; Kozar, MP; Lin, AJ; Magill, AJ; Melendez, V; Ohrt, C; Shiraki, H, 2011) |
| "Resistance of the human malarial parasite Plasmodium falciparum to the antimalarial drug chloroquine has rapidly spread from several independent origins and is now widely prevalent throughout the majority of malaria-endemic areas." | 3.77 | Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes. ( Coppens, I; Ecker, A; Fidock, DA; Lakshmanan, V; Sinnis, P, 2011) |
| "The local atomic structure around the central iron of the synthetic soluble analog of malarial pigment in acetic acid solution and with addition of chloroquine as found by X-ray absorption spectroscopy is reported." | 3.77 | Toward understanding the chloroquine action at the molecular level in antimalarial therapy--X-ray absorption studies in acetic acid solution. ( Bellemare, MJ; Bohle, DS; Kosar, AJ; Lawniczak-Jablonska, K; Sienkiewicz, A; Sikora, M; Suárez, L; Walczak, MS; Wolska, A, 2011) |
| "Chloroquine (CQ) is an important antimalarial drug for the treatment of special patient groups and as a comparator for preclinical testing of new drugs." | 3.77 | Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model. ( Batty, KT; Ilett, KF; Jago, JD; Moore, BR; Page-Sharp, M; Stoney, JR, 2011) |
| " Antimalarial chemoprophylaxis compliance with a regime of weekly chloroquine and daily proguanil was poor (30%) during OTX 1." | 3.77 | Improvements in compliance with medical force protection measures by simplification of the anti-malarial chemoprophylaxis regime. ( Green, AD; Ross, DA; Sellers, EL, 2011) |
| " Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy." | 3.77 | Prophylactic use of antimalarials during pregnancy. ( Bozzo, P; Einarson, A; Irvine, MH, 2011) |
| "Drug resistance against dihydrofolate reductase (DHFR) inhibitors-such as pyrimethamine (PM)-has now spread to almost all regions where malaria is endemic, rendering antifolate-based malaria treatments highly ineffective." | 3.76 | Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. ( Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B, 2010) |
| "Anti-malarial drug resistance in Kenya prompted two drug policy changes within a decade: sulphadoxine-pyrimethamine (SP) replaced chloroquine (CQ) as the first-line anti-malarial in 1998 and artemether-lumefantrine (AL) replaced SP in 2004." | 3.76 | Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya. ( Akala, HM; Bedno, SA; Coldren, RL; Eyase, FL; Moss, WJ; Prigge, ST; Spalding, MD; Waters, NC, 2010) |
| "Chloroquine-proguanil association is recommended for prophylaxis against falciparum malaria in countries with a low prevalence of chloroquine resistance." | 3.76 | [Duodenal ulcers caused by chloroquine-proguanil association]. ( Imbert, P; Méchaï, F; Rapp, C; Rivière, F; Roux, X, 2010) |
| "The synthesis of novel chlorovinyl sulfone-like chalcone derivatives and their antimalarial activity against cultured Plasmodium falciparum parasites, hemozoin formation, hemoglobin hydrolysis and murine malaria model are described." | 3.75 | Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities. ( Dominguez, JN; Gamboa de Dominguez, N; Gut, J; Leon, C; Rodrigues, J; Rosenthal, PJ, 2009) |
| "Synthesis of new 6-ureido-4-anilinoquinazolines have been accomplished and their in vitro antimalarial activity against chloroquine-sensitive P." | 3.75 | Search for new pharmacophores for antimalarial activity. Part II: synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines. ( Batra, S; Madapa, S; Mishra, A; Pandey, SK; Puri, SK; Srivastava, K; Tripathi, R; Tusi, Z, 2009) |
| "In an attempt to augment the efficacy of 7-chloro 4-aminoquinoline analogs and also to overcome resistance to antimalarial agents, we synthesized three cyclen (1,4,7,10-tetraazacyclododecane) analogs of chloroquine [a bisquinoline derivative, 7-chloro-4-(1,4,7,10-tetraaza-cyclododec-1-yl)-quinoline HBr, and a 7-chloro-4-(1,4,7,10-tetraaza-cyclododec-1-yl)-quinoline-Zn(2+) complex]." | 3.75 | Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs. ( Borne, RF; Khan, MO; Khan, SI; Kimura, E; Levi, MS; Tekwani, BL, 2009) |
| "A guideline which illustrated the presentation of clinical types of malaria, the appropriate steps to take for each type and the correct dosage schedule of chloroquine (based on the age of the child) for treatment of uncomplicated malaria was developed." | 3.75 | The development of a treatment guideline for childhood malaria in rural Southwest Nigeria using participatory approach. ( Ajayi, IO; Bamgboye, EA; Falade, CO; Kale, O; Oladepo, O, 2009) |
| " We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge." | 3.75 | Violacein extracted from Chromobacterium violaceum inhibits Plasmodium growth in vitro and in vivo. ( Blanco, YC; Brocchi, M; Costa, FT; Duran, N; Facchini, G; Goelnitz, U; Justo, GZ; Lopes, SC; Nogueira, PA; Rodrigues, FL; Wunderlich, G, 2009) |
| "Burkina Faso has recently changed the antimalarial drug policy to artesunate/amodiaquine or artemether/lumefantrine as the first-line antimalarial drug and sulfadoxine/pyrimethamine for the intermittent preventive treatment in pregnant woman." | 3.75 | [Change of antimalarial first-line treatment in Burkina Faso in 2005]. ( Diarra, A; Gansané, A; Konaté, AT; Nébié, I; Ouédraogo, A; Sirima, BS; Soulama, I; Tiono, A, 2009) |
| "We retrospectively assessed the impact of chloroquine (CQ) resistance in the rural region of Niakhar, Senegal, where resistance to CQ emerged in 1992, from increases in consultations and returns of patients to the health centre following antimalarial treatment." | 3.75 | Absence of an impact of resistance to chloroquine on consultations for malaria in Niakhar, Senegal (1992-2004). ( Chippaux, JP; Diallo, A; Munier, A, 2009) |
| "Antiretroviral protease inhibitors significantly potentiated the sensitivity of chloroquine-resistant malaria parasites to the antimalarial drug in vitro and in vivo." | 3.75 | Antiretroviral protease inhibitors potentiate chloroquine antimalarial activity in malaria parasites by regulating intracellular glutathione metabolism. ( Chen, L; Chen, X; He, Z; Qin, L; You, J, 2009) |
| " knowlesi infection had uncomplicated malaria that responded to chloroquine and primaquine treatment." | 3.75 | Clinical and laboratory features of human Plasmodium knowlesi infection. ( Cox-Singh, J; Daneshvar, C; Davis, TM; Divis, PC; Rafa'ee, MZ; Singh, B; Zakaria, SK, 2009) |
| " We describe a patient with recurrent malaria, prophylactically treated with low-dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction." | 3.75 | Cardiotoxicity after low-dose chloroquine antimalarial therapy. ( Baratto, F; Doglioni, C; Fragasso, G; Margonato, A; Martinenghi, S; Sanvito, F, 2009) |
| "Recently, it has been assumed that resistance of Plasmodium to chloroquine increased malaria mortality." | 3.75 | Evolution of malaria mortality and morbidity after the emergence of chloroquine resistance in Niakhar, Senegal. ( Arduin, P; Chippaux, JP; Cot, M; Diallo, A; Gning, B; Marra, A; Mboup, BM; Munier, A; Ndiaye, O, 2009) |
| "Amodiaquine (AQ) and tebuquine are 4-aminoquinoline antimalarials with Mannich base side chain and are highly effective against chloroquine (CQ)-resistant strains of Plasmodium falciparum." | 3.74 | Synthesis and antimalarial activity of new isotebuquine analogues. ( Gerena, L; Hudson, TH; Kyle, DE; Lin, AJ; Miroshnikova, OV, 2007) |
| "We have synthesized a series of sulfonylureas and have tested their antimalarial activities, including inhibition of in vitro development of a chloroquine-resistant strain of Plasmodium falciparum, in vitro hemoglobin hydrolysis, hemozoin formation, and development of Plasmodium berghei in murine malaria." | 3.74 | Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials. ( Charris, J; Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ, 2007) |
| "The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo." | 3.74 | Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1). ( Milhous, WK; Milić, D; Opsenica, D; Smith, KS; Solaja, BA; Terzić, N; Tinant, B, 2007) |
| "Primaquine is the drug of choice for the radical cure of Plasmodium vivax malaria, but possesses serious side effects." | 3.74 | Synthesis and evaluation of naphthyridine compounds as antimalarial agents. ( Gudise, C; Kong, Y; Meng, L; Smith, E; Wei, L; Zhang, Q; Zhu, S, 2007) |
| " Their antimalarial effects have been characterized in parasite assays using chloroquine-sensitive and -resistant strains of Plasmodium, alone or in drug combination, and in the Plasmodium berghei rodent model." | 3.74 | Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. ( Becker, K; Davioud-Charvet, E; Friebolin, W; Furrer, J; Jannack, B; Lanzer, M; Oeser, T; Sanchez, CP; Wenzel, N; Yardley, V, 2008) |
| "A series of diaryl ether substituted 4-pyridones have been identified as having potent antimalarial activity superior to that of chloroquine against Plasmodium falciparum in vitro and murine Plasmodium yoelii in vivo." | 3.74 | Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials. ( Batchelor, JF; Bueno, JM; Capon, EC; Cheesman, NJ; Chicharro, J; Fernández, E; Fiandor, JM; Fry, M; Gargallo-Viola, D; Gómez de las Heras, F; Herreros, E; Hudson, AT; León, ML; Pudney, M; Trimming, H; Woolven, J; Yeates, CL, 2008) |
| "The synergy of the activities between chloroquine and various human immunodeficiency virus protease inhibitors was investigated in chloroquine-resistant and -sensitive malaria parasites." | 3.74 | Synergy of human immunodeficiency virus protease inhibitors with chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo. ( Chen, L; Chen, X; He, Z; Peng, N; Qin, L; You, J, 2008) |
| " They displayed micromolar range activity on two enzymatic targets of importance for the control of malaria, the plasmodial kinase Pfnek-1 and a protein farnesyl transferase, as well as on different chloroquine-sensitive and -resistant strains of Plasmodium falciparum." | 3.74 | Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge. ( Ausseil, F; Chevalley, S; Debitus, C; Desoubzdanne, D; Doerig, C; Dorin, D; Marcourt, L; Raux, R; Valentin, A, 2008) |
| "The present study was envisaged to evaluate potential of combination therapy comprising of immunomodulator picroliv and antimalarial chloroquine against drug resistant Plasmodium yoelii (P." | 3.74 | Immunomodulator effect of picroliv and its potential in treatment against resistant Plasmodium yoelii (MDR) infection in mice. ( Dangi, A; Dwivedi, V; Fatima, N; Khan, A; Misra-Bhattacharya, S; Owais, M; Soni, VK; Vasco, A, 2008) |
| "The results of the present study suggest that chloroquine can interfere with several putative mosquito mechanisms of defense against Plasmodium at the level of gene expression and highlight the need for a better understanding of the impacts of antimalarial agents on parasite transmission." | 3.74 | Chloroquine mediated modulation of Anopheles gambiae gene expression. ( Abrantes, P; Dimopoulos, G; do Rosário, VE; Grosso, AR; Silveira, H, 2008) |
| "In West Africa, treatment for the prevention of malaria during pregnancy has recently changed from chloroquine (CQ) prophylaxis to intermittent preventive treatment (IPTp)." | 3.74 | Efficacy of intermittent preventive treatment versus chloroquine prophylaxis to prevent malaria during pregnancy in Benin. ( Briand, V; Cot, M; Denoeud, L; Massougbodji, A, 2008) |
| "This study showed that, home treatment with chloroquine significantly impacts on the outcome of severe malaria." | 3.74 | Early home treatment of childhood fevers with ineffective antimalarials is deleterious in the outcome of severe malaria. ( Amodu, OK; Olumese, PE; Omotade, OO; Orimadegun, AE, 2008) |
| "To assess the knowledge of dispensers in private pharmacies on new malaria treatment guidelines which involved switching from chloroquine (CQ) to sulfadoxine pyrimethamine (SP) and from SP to artemether-lumefantrine." | 3.74 | Poor knowledge on new malaria treatment guidelines among drug dispensers in private pharmacies in Tanzania: the need for involving the private sector in policy preparations and implementation. ( Haule, AF; Minzi, OM, 2008) |
| "Questioning was centred by frequency order on: the pregnancy antecedents (65%), the chloroquine direction for use (34." | 3.74 | [Quality of malaria prevention during prenatal consultations in Niakhar (Senegal)]. ( Faye, A; Ndiaye, P; Tal, DA, 2007) |
| "The emergence and spread of Plasmodium falciparum with resistance to chloroquine (CQ), the safest and cheapest antimalarial drug coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the need to optimize antimalarial actions of plant extracts and restore chloroquine efficacy." | 3.74 | Enhanced antimalarial effects of chloroquine by aqueous Vernonia amygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasmodium berghei strains. ( Iwalokun, BA, 2008) |
| "Methanolic extracts from 15 medicinal plants representing 11 families, used traditionally for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ)-tolerant Plasmodium berghei NK65, either alone or in combination with CQ." | 3.74 | Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice. ( Amano, T; Ishih, A; Kino, H; Miyase, T; Mkoji, GM; Muregi, FW; Suzuki, T; Terada, M, 2007) |
| "Chloroquine (CLQ) and Pyrimethamine (PYR) are used for the treatment of malaria and some autoimmune diseases; although their mechanism of action is only partially understood, their therapeutic effectiveness in the second case has been attributed to their ability to increase apoptosis of T lymphocytes." | 3.74 | Immunomodulatory role of chloroquine and pyrimethamine in Plasmodium yoelii 17XL infected mice. ( Legorreta-Herrera, M; Machuca-Rodríguez, C; Moreno-Altamirano, MM; Narváez, V; Ramos-Avila, A; Ventura-Gallegos, JL; Zentella-Dehesa, A, 2007) |
| "Hot water extracts from eight medicinal plants representing five families, used for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ) resistant Plasmodium berghei NK65, either alone or in combination with CQ." | 3.74 | In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice. ( Amano, T; Ishih, A; Kino, H; Miyase, T; Mkoji, GM; Muregi, FW; Suzuki, T; Terada, M, 2007) |
| "The anti-malarial chloroquine can modulate the outcome of infection during the Plasmodium sporogonic development, interfering with Plasmodium gene expression and subsequently, with transmission." | 3.74 | Effect of chloroquine on gene expression of Plasmodium yoelii nigeriensis during its sporogonic development in the mosquito vector. ( Abrahamsen, MS; Abrantes, P; do Rosario, VE; Lopes, LF; Ramos, S; Silveira, H, 2007) |
| "Having reliable forecasts is critical now for producers, malaria-endemic countries and agencies in order to adapt production and procurement of the artemisinin-based combination treatments (ACTs), the new first-line treatments of malaria." | 3.74 | Estimating antimalarial drugs consumption in Africa before the switch to artemisinin-based combination therapies (ACTs). ( D'Altilia, JP; Kindermans, JM; Olliaro, P; Vandenbergh, D; Vreeke, E, 2007) |
| " Anti-malaria drug policy (2007) of the NVBDC recommends chloroquine (CQ) as the first line of drug for the treatment of all malarias." | 3.74 | Battling the malaria iceberg with chloroquine in India. ( Sharma, VP, 2007) |
| "The use of the guideline with adequate training significantly improved correctness of malaria treatment with chloroquine at home." | 3.74 | Assessment of a treatment guideline to improve home management of malaria in children in rural south-west Nigeria. ( Ajayi, IO; Bamgboye, EA; Falade, CO; Kale, OO; Oduola, AM, 2008) |
| "Phenylurenyl chalcone derivatives have been synthesized and tested as inhibitors of in vitro development of a chloroquine-resistant strain of Plasmodium falciparum, activity of the cysteine protease falcipain-2, in vitro globin hydrolysis, beta-hematin formation, and murine Plasmodium berghei malaria." | 3.73 | Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. ( Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ, 2005) |
| "The antimalarial activity of chloroquine-pyrazole analogues, synthesized from the reaction of 1,1,1-trifluoro-4-methoxy-3-alken-2-ones with 4-hydrazino-7-chloroquinoline, has been evaluated in vitro against a chloroquine resistant Plasmodium falciparum clone." | 3.73 | Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues. ( Bonacorso, HG; Cechinel, CA; Cunico, W; de Souza, MV; Freitas, IO; Krettli, AU; Martins, MA; Soares, RP; Zanatta, N, 2006) |
| "Using easily accessible keto-trioxanes 7a-g as the starting materials, a series of new variously functionalized 1,2,4-trioxanes 10-36 have been prepared and evaluated for antimalarial activity against multi-drug-resistant Plasmodium yoelii nigeriensis in mice in the dose range of 24 mg/kg x 4 days to 96 mg/kg x 4 days by oral route." | 3.73 | Orally active 1,2,4-trioxanes: synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant plasmodium yoelii nigeriensis in mice. ( Malik, H; Puri, SK; Singh, C, 2006) |
| "Febrifugine (1), a quinazoline alkaloid, isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum." | 3.73 | Exploration of a new type of antimalarial compounds based on febrifugine. ( Hariguchi, N; Hirai, S; Horoiwa, S; Kasahara, R; Kikuchi, H; Matsumoto, M; Oshima, Y; Yamamoto, K, 2006) |
| "An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasmodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria." | 3.73 | Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites. ( Chibale, K; Chouteau, F; Ramanitrahasimbola, D; Rasoanaivo, P, 2005) |
| "The direct antimalarial activity of ferroquine (FQ, SSR97193), a chloroquine (CQ) derivative, is well established." | 3.73 | Analysis of immune response patterns in naïve and Plasmodium berghei-infected young rats following a ferroquine treatment. ( Brocard, J; Dive, D; Fraisse, L; Khalife, J; Lafitte, S; Pierrot, C, 2005) |
| "In 126 Ghanaian children with uncomplicated malaria, associations between mutations conferring resistance in the Plasmodium falciparum dihydrofolate reductase (dhfr; SP) and chloroquine resistance transporter (crt; CQ) genes, concentrations of residual antimalarial drugs, and gametocyte carriage were examined." | 3.73 | Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana. ( Bienzle, U; Bousema, JT; Eggelte, TA; Ehrhardt, S; Mockenhaupt, FP; Otchwemah, RN; Sauerwein, RW, 2005) |
| "To evaluate treatment practices for uncomplicated malaria after the policy change from chloroquine to sulfadoxine-pyrimethamine and to artemether-lumefantrine in Zambia." | 3.73 | Treatment of paediatric malaria during a period of drug transition to artemether-lumefantrine in Zambia: cross sectional study. ( Hamer, DH; Ndhlovu, M; Rowe, AK; Snow, RW; Thea, DM; Zurovac, D, 2005) |
| "We examined whether the initial number of parasites inoculated and the starting day of medication post-infection influenced the antimalarial efficacy of chloroquine (CQ) against Plasmodium berghei NK65 infection in ICR mice." | 3.73 | Chloroquine efficacy in Plasmodium berghei NK65-infected ICR mice, with reference to the influence of initial parasite load and starting day of drug administration on the outcome of treatment. ( Ishih, A; Matsui, K; Muregi, FW; Suzuki, T; Terada, M, 2006) |
| "The anti-malarial agent chloroquine has activity against HIV." | 3.73 | Impact of chloroquine on viral load in breast milk. ( Aldrovandi, G; Ghosh, M; Kankasa, C; Kasonde, P; Kuhn, L; Semrau, K; Shutes, E; Sinkala, M; Thea, DM; Vwalika, C, 2006) |
| "Amodiaquine (AQ) (2) is a 4-aminoquinoline antimalarial that can cause adverse side effects including agranulocytosis and liver damage." | 3.72 | Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials. ( Bickley, JF; Bray, PG; Hindley, S; Hughes, RH; Maggs, JL; Mukhtar, A; O'Neil, IA; O'Neill, PM; Park, BK; Randle, LE; Stocks, PA; Storr, RC; Ward, SA; Winstanley, PA, 2003) |
| "To eliminate an unwarranted metabolic pathway of the quinoline ring, a set of two compounds, where C-2 position of the antimalarial drug primaquine is blocked by metabolically stable bulky alkyl group are synthesized." | 3.72 | Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity. ( Jain, M; Jain, R; Jena, GB; Kaul, CL; Ramarao, P; Sachdeva, S; Singh, PP; Singh, S; Tikoo, K; Vangapandu, S, 2004) |
| "The antimalarial activity of benzo[a]phenazines synthesized from 1,2-naphthoquinone, lapachol, beta-lapachone and several derivatives have been tested against Plasmodium falciparum in vitro using isolates of parasites with various susceptibilities to chloroquine and/or mefloquine." | 3.72 | Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. ( Carvalho, LH; da Silva Filho, JF; da Silva, MJ; de Andrade-Neto, VF; Goulart, MO; Krettli, AU; Pinto, AV; Pinto, Mdo C; Zalis, MG, 2004) |
| "To study the relationship between neutral aminopeptidase activity and hemoglobin accumulation in malaria parasites, we treated mice infected with Plasmodium berghei NYU-2 with chloroquine intraperitoneally in doses ranging from 0." | 3.72 | Relationship of chloroquine-induced redistribution of a neutral aminopeptidase to hemoglobin accumulation in malaria parasites. ( Cai, GZ; Chen, YF; Fitch, CD; Ryerse, JS, 2003) |
| "The influence of combinations containing the blood schizontocides chloroquine (CQ) or mefloquine (MEF), together with the 8-aminoquinolines (8AQ) primaquine (PQ) or the new, long-acting compound, tafenoquine (TAF), on the rate of selection of resistance to the individual compounds was examined using the asexual, intra-erythrocytic stages in rodent malaria models." | 3.72 | The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines. ( Peters, W; Robinson, BL; Stewart, LB, 2003) |
| "To study the antimalarial effect of agmatine (Agm) on chloroquine-susceptible Plasmodium berghei K173 strain (S strain) and the P berghei K173 resistant strain (R strain)." | 3.72 | Antimalarial effect of agmatine on Plasmodium berghei K173 strain. ( Li, J; Liu, Y; Su, RB; Wei, XL, 2003) |
| " A major determinant of compliance with treatment in this environment is the pruritus chloroquine induces when ingested." | 3.72 | Pattern of chloroquine-induced pruritus in antenatal patients at the University College Hospital, Ibadan. ( Adeniji, AR; Aimakhu, CO; Fehintola, FA; Olayemi, O; Osungbade, A; Udoh, ES, 2003) |
| "Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance." | 3.72 | The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. ( , 2003) |
| "Chloroquine and related anti-malarial drugs appear to promote apoptosis in T-cells by suppressing NF-kappa-B, which enhances the expression of anti-apoptotic proteins (e." | 3.72 | Hypothesis links emergence of chloroquine-resistant malaria and other intracellular pathogens and suggests a new strategy for treatment of diseases caused by intracellular parasites. ( Parris, GE, 2004) |
| " One-third of general retailers stocking drugs had antimalarials, usually chloroquine alone." | 3.72 | Retail supply of malaria-related drugs in rural Tanzania: risks and opportunities. ( Abdulla, S; Bloland, P; Goodman, C; Kachur, SP; Mills, A; Mwageni, E; Nyoni, J; Schellenberg, JA, 2004) |
| "To document successful community chloroquine distribution for malaria control in Bushenyi district, southwestern Uganda." | 3.72 | Community chloroquine distribution for malaria control in Bushenyi district of Uganda. ( Nuwaha, F; Okware, J; Timbyetaho, HN, 2003) |
| "The effects of p-chlorophenylalanine, an inhibitor of serotonin synthesis, indomethacin, an inhibitor of prostaglandin synthesis, cyproheptadine, a serotonin, bradykinin and histamine antagonist, were assessed separately and in combination with chloroquine (CQ) in Vom strains of Swiss albino mice (18-22 g) of either sex infected intraperitoneally with 1 x 10(7) Plasmodium yoelii nigeriensis-induced malaria." | 3.72 | Effects of autacoid inhibitors and of an antagonist on malaria infection in mice. ( Agbani, EO; Iwalewa, EO, 2004) |
| "The role of haem iron (II) and oxidative stress in the activation and antimalarial activity of artemisinin is unclear." | 3.72 | Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin. ( Basilico, N; Mondani, M; Monti, D; Olliaro, P; Parapini, S; Taramelli, D, 2004) |
| " The physiological hormone dehydroepiandrosterone sulfate (DHEAS) is a potent inhibitor of G6PD activity, and G6PD deficiency is known to exert antimalaria protection." | 3.72 | Plasmodium berghei: dehydroepiandrosterone sulfate reverses chloroquino-resistance in experimental malaria infection; correlation with glucose 6-phosphate dehydrogenase and glutathione synthesis pathway. ( Haumont, G; Malvy, D; Mangou, F; Millet, P; Mossalayi, D; Olliaro, P; Safeukui, I; Vatan, R; Vincendeau, P, 2004) |
| "Chloroquine remains the first line antimalarial drug in Ghana." | 3.72 | Antimalarial drug use among caregivers in Ghana. ( Abuaku, BK; Binka, FN; Koram, KA, 2004) |
| "This study was carried out in the village of Faladié, Mali located in the malaria-endemic Kati region, two years after routine use of chloroquine prophylaxis was discontinued in children 0 to 9 years old." | 3.72 | [Assessment of chloroquine resistance two years after stopping chemoprophylaxis in 0 to 9-year-old children living in a malaria-endemic village of Mali]. ( Diallo, M; Diawara, A; Doumbo, O; Sacko, M; Sangho, H; Sango, HA; Sow, S, 2004) |
| "The potent antimalarial activity of chloroquine against chloroquine-sensitive strains can be attributed, in part, to its high accumulation in the acidic environment of the heme-rich parasite food vacuole." | 3.71 | Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues. ( Bray, PG; Davies, J; Hindley, S; O'Neill, PM; Park, BK; Searle, NL; Storr, RC; Ward, SA, 2002) |
| "Although febrifugine (1) and isofebrifugine (2), alkaloids isolated from roots of the Dichroa febrifuga plant, show powerful antimalarial activity against Plasmodium falciparum, strong side effects such as the emetic effect have precluded their clinical use against malaria." | 3.71 | Potent antimalarial febrifugine analogues against the plasmodium malaria parasite. ( Hatakeyama, S; Hirai, S; Iwabuchi, Y; Kikuchi, H; Kim, HS; Ooi, H; Oshima, Y; Takaya, Y; Tasaka, H; Wataya, Y, 2002) |
| "Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro." | 3.71 | Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine. ( Biswas, S; Dua, VK; Puri, SK; Sharma, VP; Sinha, SN; Valecha, N, 2002) |
| " The aim was to test the impact of a combination of improved information provision to patients and drug labeling on adherence to recommended anti-malarial treatment regimens focusing on oral chloroquine, for the outpatient management of acute uncomplicated malaria." | 3.71 | Strategies to improve adherence to recommended chloroquine treatment regimes: a quasi-experiment in the context of integrated primary health care delivery in Ghana. ( Adjei, S; Agyepong, IA; Ansah, E; Barnish, G; Evans, D; Gyapong, M, 2002) |
| "A retrospective examination was made of archival data on the response of Plasmodium malariae infections in humans to chloroquine." | 3.71 | Extended clearance time after treatment of infections with Plasmodium malariae may not be indicative of resistance to chloroquine. ( Collins, WE; Jeffery, GM, 2002) |
| "Following the severe malaria outbreak in the central highlands in Madagascar in 1986, a vector control program by use DDT pm 75 house-spraying has been implemented to operate in areas located at altitudes between 1000 and 1500 m." | 3.71 | [Geographic approach in malaria control in the central highlands of Madagascar]. ( Ariey, F; Duchemin, JB; Jeanne, I; Pietra, V; Raharimalala, L; Rakotomanana, F; Tombo, ML, 2001) |
| "The hypothesis that chloroquine-induced pruritus (CIP) may be determined by certain genetic factors was tested by investigating the epidemiology of CIP with respect to certain genetic red cell markers namely, haemoglobin genotype, glucose-6-phosphate dehydrogenase (G6PD) deficiency and the ABO blood groups." | 3.71 | Certain red cell genetic factors and prevalence of chloroquine-induced pruritus. ( Ademowo, OG; Sodeinde, O, 2002) |
| "A child with malaria from a chloroquine-resistant area received an accidental overdose of chloroquine administered by a parent." | 3.71 | Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity. ( Corry, A; Fitzmaurice, L; Jackson, MA; Kearns, GL; Lowry, JA, 2001) |
| " citizens died from malaria after taking chloroquine alone or with proguanil for malaria chemoprophylaxis in countries with known chloroquine-resistant Plasmodium falciparum malaria." | 3.71 | Malaria deaths following inappropriate malaria chemoprophylaxis--United States, 2001. ( , 2001) |
| "In the fight against malaria, chemotherapy using bisacridines may represent an alternative method to overcoming chloroquine-resistance." | 3.71 | Antimalarial in-vivo activity of bis(9-amino-6-chloro-2-methoxyacridines). ( Berecibar, A; Debreu-Fontaine, MA; Delarue, S; Girault, S; Grellier, P; Lemiere, P; Maes, L; Quirijnen, L; Sergheraert, C, 2001) |
| "To assess the effect of introducing chloroquine prophylaxis during pregnancy on prevalence of anemia (<10." | 3.71 | Malaria prophylaxis and the reduction of anemia at childbirth. ( Addae, V; Asare, K; Geelhoed, DW; Schagen van Leeuwen, JH; van Roosmalen, J; Visser, LE, 2001) |
| " The aim was to provide a baseline understanding of illness behaviour on which to build a programme for the promotion of prepackaged chloroquine and cotrimoxazole for early and appropriate treatment of childhood fevers at the community level." | 3.71 | Treatment of childhood fevers and other illnesses in three rural Nigerian communities. ( Adeneye, AK; Afolabi, BM; Agomo, PU; Akinlade, CO; Asa, S; Brieger, WR; Nwankwo, BO; Salako, LA; Umeh, RE, 2001) |
| "Chloroquine retinopathy (CR) is a major complication of long-term malaria prophylaxis (LTMP) causing permanent visual dysfunction and occasionally blindness." | 3.71 | Case report: Retinopathy after malaria prophylaxis with chloroquine. ( Bertagnolio, S; Camilli, G; Tacconelli, E; Tumbarello, M, 2001) |
| " Of the antimalarial treatments given at home, 91% were started by the second day of fever and 92% were with chloroquine, the nationally recommended antimalarial at the time." | 3.71 | Malaria control in Bungoma District, Kenya: a survey of home treatment of children with fever, bednet use and attendance at antenatal clinics. ( Deming, MS; Hamel, MJ; Odhacha, A; Roberts, JM, 2001) |
| "Prior to policy change from chloroquine (CQ) to sulphadoxine/pyrimethamine (S/P; Fansidar) we assessed the perception of CQ efficacy and the alternative treatment options for malaria in children among parents/guardians (N=527) of under-fives attending first level health facilities on account of fever." | 3.71 | Perception of chloroquine efficacy and alternative treatments for uncomplicated malaria in children in a holoendemic area of Tanzania: implications for the change of treatment policy. ( Bygbjerg, IC; Minjas, JN; Tarimo, DS, 2001) |
| "Access to effective treatment would substantially reduce the burden of malaria in sub-Saharan Africa, but resistance to chloroquine, the most commonly used first line drug, is now widespread." | 3.71 | Changing the first line drug for malaria treatment--cost-effectiveness analysis with highly uncertain inter-temporal trade-offs. ( Coleman, PG; Goodman, CA; Mills, AJ, 2001) |
| "To study case management of malaria in children under 5 years of age at primary health care facilities in Kibaha district, Tanzania and to evaluate the accuracy of self-reported mothers'/guardians' information on chloroquine use in children." | 3.71 | Case management of malaria in under-fives at primary health care facilities in a Tanzanian district. ( Eriksen, J; Gustafsson, LL; Massele, AY; Nsimba, SE; Tomson, G; Warsame, M, 2002) |
| "To evaluate the quality of pharmaceutical care of malaria for children in eastern Uganda prescribed at government health units and drug shops, and administered by caretakers at home; and to assess its appropriateness in relation to national treatment guidelines, which recommend chloroquine over 3 days." | 3.71 | Appropriate treatment of malaria? Use of antimalarial drugs for children's fevers in district medical units, drug shops and homes in eastern Uganda. ( Kristensen, M; Nshakira, N; Ssali, F; Whyte, SR, 2002) |
| "Study of children treated for uncomplicated malaria in the sub-prefecture of Zouan Hounien in Western Côte d'Ivoire demonstrated that clinical failure rates (WHO 14-day test) were 43% for chloroquine and 6% for pyrimethamine-sulfadoxine (PS)." | 3.71 | [Which medication should be used to treat uncomplicated malaria when chloroquine becomes ineffective in Western Côte d'Ivoire?]. ( Henry, MC; Kone, M; Niangue, J, 2002) |
| "Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy." | 3.70 | Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy. ( Edwards, R; Fuchs, E; Kerr, L; Phillips-Howard, PA; Schildknecht, J; Steffen, R; Vanhauwere, B, 1998) |
| "A 23 year old man with no history of neurological or psychiatric illness ingested three weekly 228 mg doses of mefloquine base (250 mg salt) as malaria prophylaxis while in India." | 3.70 | A severe adverse reaction to mefloquine and chloroquine prophylaxis. ( Kvern, BL; Lysack, CL; Lysack, JT, 1998) |
| "Self-treatment of malaria with chloroquine is extremely common in West Africa for the febrile attacks self-diagnosed as a presumed malaria case." | 3.70 | [Sale of chloroquine in the street in Niamey (Niger)]. ( Julvez, J, 1999) |
| " We evaluated the training by measuring changes in the proportions of drug sales where an adequate amount of chloroquine was purchased and in the percentage of home-treated childhood fevers given an adequate amount of chloroquine." | 3.70 | Changing home treatment of childhood fevers by training shop keepers in rural Kenya. ( Haaland, A; Marsh, K; Marsh, VM; Mutemi, WM; Muturi, J; Otieno, G; Watkins, WM, 1999) |
| "The spectrum of antimalarial activity of the new macrolide antibiotic azithromycin was evaluated against blood- and sporozoite-induced infections with a chloroquine-resistant strain of Plasmodium yoelii nigeriensis (N-67) in Swiss mice and with simian parasite Plasmodium cynomolgi B in rhesus monkeys." | 3.70 | Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys. ( Puri, SK; Singh, N, 2000) |
| " Mefloquine should be recommended as prophylaxis to the majority of travellers visiting regions with chloroquine-resistant malaria." | 3.70 | [Malaria imported to Norway 1989-98]. ( Blystad, H, 2000) |
| "As an approach to explain the possible in vivo interaction of paracetamol (acetaminophen) with various chloroquine salts that are often administered during malaria tropica, the effects of these salts (chloroquine sulphate, chloroquine phosphate, chloroquine hydrochloride and ferrous sulphate) were examined in male rats." | 3.70 | The contributions of various chloroquine salts to the biliary and urinary execretion of hepatic paracetamol conjugation metabolites in the rat. ( Anyogo, S; Oforah, E, 2000) |
| "Oxygenated chalcones (3a,b) and bischalcones (4a-j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice." | 3.70 | Oxygenated chalcones and bischalcones as potential antimalarial agents. ( Chandra, S; Ram, VJ; Saxena, AS; Srivastava, S, 2000) |
| "The effect of a number of pharmacological agents on the enhancement of antimalarial activity of chloroquine was evaluated against chloroquine resistant line of Plasmodium yoelii nigeriensis (N-67)." | 3.70 | Interaction between chloroquine and diverse pharmacological agents in chloroquine resistant Plasmodium yoelii nigeriensis. ( Puri, SK; Singh, N, 2000) |
| "Several compounds in current clinical use as antihistaminic agents, among them cyproheptadine (CYP), have been shown, in experimental models, to reverse resistance of the asexual, intra-erythrocytic stages of rodent or human malarial parasites to chloroquine (CQ)." | 3.70 | The chemotherapy of rodent malaria. LIX. Drug combinations to impede the selection of drug resistance, Part 3: Observations on cyproheptadine, an antihistaminic agent, with chloroquine. ( Butcher, GA; Peters, W; Robinson, BL; Stewart, LB, 2000) |
| "The antimalarial peroxide, dispiro-1,2,4,5-tetraoxane WR 148999, was synergistic with chloroquine, quinine, mefloquine, and artemisinin against both D6 and W2 clones of Plasmodium falciparum." | 3.70 | Assessment of the antimalarial potential of tetraoxane WR 148999. ( Ager, AL; Andersen, SL; Angerhofer, CK; Grace, JM; Hu, JK; Vennerstrom, JL; Wesche, DL; Wongpanich, V, 2000) |
| "The antimalarial activities of ferrocenic compounds mimicking chloroquine and active upon chloroquine-resistant strains of Plasmodium falciparum were evaluated." | 3.69 | Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue. ( Biot, C; Brocard, JS; Glorian, G; Maciejewski, LA, 1997) |
| " He used chloroquine as a malaria prophylaxis during his stay and for 6 weeks after his return to Japan." | 3.69 | [A case of Plasmodium ovale malaria with thrombocytopenia and an abnormality grade in FDP concentration despite the use of chloroquine as a malaria prophylaxis]. ( Karino, T; Miyashita, N; Nagatomo, Y; Nakajima, M; Niki, Y; Okimoto, N; Soejima, R; Yoshida, K, 1995) |
| "Chloroquine continues to have a limited role in the chemoprophylaxis against malaria." | 3.69 | No evidence for chloroquine-associated retinopathy among missionaries on long-term malaria chemoprophylaxis. ( Contoreggi, CS; Frame, JD; Frankenfield, DL; Lange, WR; Moriarty-Sheehan, M, 1994) |
| " vivax malaria attacks were treated with quinine or chloroquine plus primaquine." | 3.69 | Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon. ( Camargo, LM; Cardoso, MA; Ferreira, MU; Szarfarc, SC, 1994) |
| "Ajoene (4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a product initially isolated from extracts of garlic (Allium sativum), was tested for its antimalarial activity in vivo in a well-characterized murine model." | 3.69 | In vivo activity of ajoene against rodent malaria. ( Apitz, R; De la Rosa, M; Perez, HA, 1994) |
| "A severe flare-up of chronic hepatitis B infection with liver cell insufficiency has been observed in two patients after discontinuation of chloroquine administered either as malaria prophylaxis or as treatment of presumed rheumatoid arthritis." | 3.69 | [Reactivation of hepatitis B following withdrawal of chloroquine]. ( Helbling, B; Reichen, J, 1994) |
| "The resurgence of malaria in form of resistance against chloroquine (CQ) has decreased the importance of the drug as a chemotherapeutic agent." | 3.69 | Evaluation of resistant-reversal, CDRI compound 87/209 and its possible mode of action in rodent experimental malaria. ( Bhaduri, AP; Pandey, VC; Srivastava, R, 1995) |
| " As Ivelip showed no interference with the antimalarial activity of chloroquine, it could be considered for use in the treatment of severe human malaria in association with 4-aminoquinolines to expedite the clearance of parasites." | 3.69 | Antimalarial properties of soy-bean fat emulsions. ( Baccam, D; Deharo, E; Ginsburg, H; Krugliak, M, 1995) |
| "To compare the frequency of adverse events, particularly neuropsychiatric effects, from mefloquine and from chloroquine plus proguanil as used for malaria chemoprophylaxis." | 3.69 | Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers. ( Barrett, PJ; Bradley, DJ; Clarke, PD; Emmins, PD, 1996) |
| "We have synthesized several 4-aminoquinolines with shortened side chains that retain activity against chloroquine-resistant isolates of Plasmodium falciparum malaria (W." | 3.69 | 4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum. ( Dorn, A; Girometta, MA; Guenzi, A; Hofheinz, W; Huber, W; Jaquet, C; Jolidon, S; Masciadri, R; Matile, H; Peters, W; Richter, WF; Ridley, RG; Thaithong, S; Urwyler, H, 1996) |
| "Chloroquine is widely used in malaria chemotherapy." | 3.69 | Carboxylic ionophores in malaria chemotherapy: the effects of monensin and nigericin on Plasmodium falciparum in vitro and Plasmodium vinckei petteri in vivo. ( Adovelande, J; Schrével, J, 1996) |
| "The antimalarial activity of boiled water extracts of two medicinal plants (Cymbopogon giganteus and Enantia chlorantha) against chloroquine resistant Plasmodium yoelii nigeriensis in albino mice was assessed." | 3.69 | Efficacy of Cymbopogon giganteus and Enantia chrantha against chloroquine resistant Plasmodium yoelii nigeriensis. ( Fagbenro-Beyioku, AF; Kimbi, HK, 1996) |
| "In this study we describe the application of a bioassay for measuring chloroquine equivalent concentrations in plasma samples obtained from soldiers on chloroquine (300 mg weekly) and doxycycline (50 or 100 mg daily) for malaria prophylaxis." | 3.69 | Chloroquine bioassay of plasma specimens obtained from soldiers on chloroquine plus doxycycline for malaria prophylaxis. ( Edstein, MD; Kotecka, BM; Rieckmann, KH, 1996) |
| "Fenozan B07, a 1,2,4-trioxane endoperoxide with potent blood schizontocidal activity against drug-sensitive and drug-resistant rodent malaria parasites, exerted a modest potentiating action when administered with chloroquine (CQ) to mice infected with parasites of the CQ-resistant P." | 3.69 | The chemotherapy of rodent malaria. LIV. Combinations of 'Fenozan B07' (Fenozan-50F), a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane, with other drugs against drug-sensitive and drug-resistant parasites. ( Fleck, SL; Peters, W; Robinson, BL, 1997) |
| " Two subgroups used malaria prophylaxis (mefloquine or proguanil/proguanil-chloroquine): the control group used no prophylaxis." | 3.69 | [Not more symptoms with mefloquine use than with other drugs in malaria prophylaxis]. ( Bosje, T; Luinstra-Passchier, MJ; Wolters, BA, 1997) |
| "The sensitivity to chloroquine according to the degree of synchronicity of Plasmodium yoelii nigeriensis, which is considered to be the most resistant of the rodent malaria strains, was studied." | 3.69 | Plasmodium yoelii nigeriensis: biological mechanisms of resistance to chloroquine. ( Altemayer-Caillard, V; Beauté-Lafitte, A; Chabaud, AG; Landau, I, 1994) |
| "Routine malaria prophylaxis with chloroquine (CQ) is recommended to pregnant semi-immune women in several countries in Africa." | 3.69 | Chloroquine blood concentrations and malaria prophylaxis in Tanzanian women during the second and third trimesters of pregnancy. ( Aden Abdi, Y; Diwan, VK; Ericsson, O; Gustafsson, LL; Kilewo, C; Massele, AY; Rimoy, G; Tomson, G, 1997) |
| "On the basis of observations that several bisquinolines such as piperaquine possess notable activity against chloroquine-resistant malaria, 13 N,N-bis-(7-chloroquinolin-4-yl)alkanediamines were synthesized and screened against Plasmodium falciparum in vitro and Plasmodium berghei in vivo." | 3.68 | Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. ( Ager, AL; Andersen, SL; Ellis, WY; Gerena, L; Milhous, WK; Vennerstrom, JL, 1992) |
| "Five cases of malaria were detected among cocaine users by the local health service in Bauru, a city with a population of 260,000, located 324 km from S." | 3.68 | [Outbreak of malaria induced among users of injectable drugs]. ( Andriguetti, MT; Barata, LC; de Matos, MR, 1993) |
| "To evaluate the response of heme polymerase to treatment of malaria with chloroquine, we used mice infected with Plasmodium berghei." | 3.68 | Control of heme polymerase by chloroquine and other quinoline derivatives. ( Chou, AC; Fitch, CD, 1993) |
| "Several antibiotics that inhibit protein synthesis on 70S ribosomes, including the macrolide erythromycin, and the azalides azithromycin (ZITHROMAX) and CP-63,956, demonstrated antimalarial activity against two strains of Plasmodium berghei." | 3.68 | Antimalarial activity of azithromycin and erythromycin against Plasmodium berghei. ( Gingras, BA; Jensen, JB, 1993) |
| "The antimalarial activity of beta-artemether and beta-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P." | 3.68 | Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. ( Ager, AL; Canfield, CJ; Heiffer, MH; Klayman, DL; Kyle, DE; Milhous, WK; Rossan, RN; Schuster, BG; Shmuklarsky, MJ; Tang, DB, 1993) |
| "Catabolism of host hemoglobin by the malaria parasite liberates required amino acid precursors, but is also releases large amounts of potentially toxic heme that accumulates in parasite food vacuoles during intra-erythrocytic development." | 3.68 | Hemoglobin catabolism and host-parasite heme balance in chloroquine-sensitive and chloroquine-resistant Plasmodium berghei infections. ( Eaton, JW; Wood, PA, 1993) |
| "An oligomeric ester of prostaglandin B2 (OC-5186) was found to reverse chloroquine resistance in the murine malarial parasite Plasmodium berghei." | 3.68 | Reversal of chloroquine resistance in murine malaria parasites by prostaglandin derivatives. ( Chandra, S; Dhawan, BN; Ohnishi, ST, 1993) |
| "A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice." | 3.68 | Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine. ( Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Rudolph, R, 1992) |
| "A middle-age woman had intermittently had chloroquine as an antimalarial agent for 21 years." | 3.68 | Persisting chloroquine-induced myasthenia? ( De Bleecker, J; De Reuck, J; Meire, F; Quatacker, J, 1991) |
| "Reversal of chloroquine (CQ) resistance by verapamil, a Ca2+ antagonist, has been shown in CQ-resistant human and rodent malaria parasites." | 3.68 | Ultrastructural changes associated with reversal of chloroquine resistance by verapamil in Plasmodium chabaudi. ( Kimata, I; Miki, A; Ohsawa, K; Tanabe, K, 1991) |
| "To confirm reports that chloroquine-induced pruritus might have a negative impact on chloroquine utilization on malaria control in Dar es Salaam, a precoded questionnaire was administered to 300 malaria patients and the respondents were then followed up at their homes during the period of their malaria treatment." | 3.68 | Chloroquine-induced pruritus: its impact on chloroquine utilization in malaria control in Dar es Salaam. ( Kihamia, CM; Mnyika, KS, 1991) |
| "The antimalarial chloroquine, by virtue of its weak base properties, concentrates in the acidic compartment(s) of the intraerythrocytic parasite." | 3.68 | Kinetic modelling of chloroquine uptake by malaria-infected erythrocytes. Assessment of the factors that may determine drug resistance. ( Ginsburg, H; Stein, WD, 1991) |
| "Most nonimmune patients with Plasmodium falciparum infection are no longer cured by such standard antimalarial drugs as chloroquine." | 3.68 | Interferon-gamma enhances the effect of antimalarial chemotherapy in murine Plasmodium vinckei malaria. ( Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Schermuck, S; Sliwa, K, 1991) |
| "Data from the US National Malaria Surveillance System were analyzed to assess characteristics of travelers who acquired Plasmodium falciparum infections in Africa and evaluate the impact of chloroquine resistance on the incidence of imported malaria." | 3.68 | Imported Plasmodium falciparum malaria in American travelers to Africa. Implications for prevention strategies. ( Bloland, P; Campbell, CC; Howell, BJ; Lackritz, EM; Lobel, HO, 1991) |
| "Eighteen patients with Plasmodium vivax malaria were prospectively evaluated to assess the time of onset and extent of upper gastrointestinal mucosal injury caused by oral administration of four tablets (600-mg base) of chloroquine." | 3.68 | Endoscopic assessment of chloroquine phosphate-induced damage to esophageal, gastric, and duodenal mucosa. ( Bhasin, DK; Chhina, RS; Sachdeva, JR, 1991) |
| " falciparum isolates collected from children with malaria were tested for their susceptibility to chloroquine, mefloquine and quinine in vitro using the WHO microtest system." | 3.68 | Chloroquine-resistant Plasmodium falciparum with reduced sensitivity in vitro to mefloquine and quinine in Zaria, northern Nigeria. ( Abua, JU; Lege-Oguntoye, L; Ogala, WN; Olurinola, PF; Slotboom, AB; Werblinska, B, 1991) |
| "Although the use of chloroquine (C) and hydroxychloroquine (HC) in the treatment of malaria prophylaxis during pregnancy is probably safe, the use of much higher doses for treatment of systemic lupus erythematosus (SLE) and rheumatoid arthritis during pregnancy has been controversial." | 3.68 | Pregnancy outcome following first trimester exposure to chloroquine. ( Buskila, D; Gladman, DD; Koren, G; Levy, M; Urowitz, MB, 1991) |
| "Two patients with psoriasis vulgaris who travelled to endemic malaria areas developed erythroderma and generalized psoriasis guttata 3-4 weeks after starting prophylactic antimalarial medication with chloroquine/proguanil." | 3.68 | [Exacerbation of psoriasis caused by malaria prophylaxis with chloroquine and proguanil]. ( Damstra, RJ; van Vloten, WA, 1991) |
| " In the clinical study, 125 patients given intramuscular chloroquine for malaria were followed for 2 months in order to detect local injection site complications." | 3.68 | Acute gluteal abscess following intramuscular chloroquine injection: a clinical and experimental study. ( Ahmed, ME; elHassan, AM; elZaki, K; Fahal, AH; Yousif, MA, 1991) |
| "A simplified in-vivo test system was applied to detect chloroquine resistance in malaria patients in Shahjahanpur district (Uttar Pradesh) in India." | 3.68 | Application of a simplified in-vivo test system for determining chloroquine resistance in Plasmodium falciparum. ( Prasad, H; Prasad, RN; Sharma, VP; Virk, KJ, 1990) |
| "Forty-seven new acridone alkaloid derivatives (SA compounds) were tested for antimalarial activity in vitro." | 3.68 | Activities of new acridone alkaloid derivatives against Plasmodium yoelii in vitro. ( Fujimura, K; Fujioka, H; Fujita, M; Kato, N; Nishiyama, Y, 1990) |
| "Recently introduced chloroquine resistant malaria has altered the clinical picture and complicated the overall management of malaria." | 3.68 | Complications of seasonal adult malaria at a central hospital. ( Lutalo, SK; Mabuwa, C, 1990) |
| "In view of the emergence of chloroquine resistant Plasmodium falciparum from more and more geographical areas profiling of the responses to other available antimalarials by in vitro methods have become essential." | 3.68 | An in-vitro profile of the action of four antimalarials on indigenous cases of Plasmodium falciparum malaria in Karnataka. ( Chakrabarti, NK; Nagaraj, C; Narasimham, MV, 1990) |
| "From 1986 until 1988 chloroquine sensitivity of Plasmodium falciparum malaria was monitored in 515 hospital patients in Nchelenge district, northeastern Zambia." | 3.68 | Chloroquine-resistant Plasmodium falciparum malaria at Nchelenge, northeastern Zambia. Follow-up on 515 hospital patients. ( Gernaat, HB; Verhagen, MA; Woods, SM, 1990) |
| "59 cases of Plasmodium falciparum malaria fever occurring in non-immune Caucasian subjects having got a correct chemoprophylaxis by chloroquine were treated by halofantrine (HALFAN)." | 3.68 | [The treatment of imported Plasmodium falciparum malaria with halofantrine. Apropos of 59 case reports (corrected and republished article orginally printed in Med Trop (Mars) 1990 Jan-Mar;50(1):113-7)]. ( Becker, JM; Bernard, J; Dupasquier, I; Geffray, L; Gimenez, M; Jourdan, G; Lesbordes, JL; Molinas, JM; Sarrouy, J, 1990) |
| "An attack of malaria can be lethal; however, besides this classic form, clinical cases are less brutal, often with blood disorders, related to Plasmodium falciparum infection resistant to chloroquine." | 3.68 | [Uncommon clinical aspects of Plasmodium falciparum malaria]. ( Beaudoing, A; François, P; Moyat, G; Peyron, F; Plasse, M; Thierry, MH, 1990) |
| "Six hundred and twenty pregnant women, living under conditions of year-round transmission of malaria in a rural coastal area of Madang, Papua New Guinea (PNG), were followed while attending mobile antenatal clinics and receiving chloroquine prophylaxis (300 mg base weekly)." | 3.68 | Failure of chloroquine prophylaxis for falciparum malaria in pregnant women in Madang, Papua New Guinea. ( Alpers, M; Brabin, BJ; Brabin, L; Eggelte, T; Ginny, M; Van der Kaay, HJ, 1990) |
| "The good results achieved in the treatment of malaria with a 7 and 5 days one of quinine (orally dose 8 mg/kg/8 h), incited the authors to try a 3 days long treatment at the same dose." | 3.68 | [Uncomplicated attack of malaria in an area with high resistance to chloroquine. I. Evaluation of a short treatment with quinine]. ( Abissegue, B; Farinotti, R; Gelas, H; Ghipponi, PM; Hengy, C; Jambou, R; Le Bras, J, 1990) |
| "The authors evaluate the comparative efficiency of chloroquine and amodiaquine (35 mg/kg during 3 days) for uncomplicated malaria treatment in an area with high chemoresistance level." | 3.68 | [Uncomplicated malaria attack in an area with high chloroquine resistance. 2. Evaluation of first-choice therapeutic scheme]. ( Arrive, A; Eberlé, F; Gazin, P; Hengy, C; Jambou, R; Kouka-Bemba, D, 1990) |
| "In October and November 1988 we carried out in vivo Plasmodium falciparum sensitivity tests for chloroquine in the town of Dakar, where malaria is endemic with increased transmission during the rainy season (July to October)." | 3.68 | [The emergence of chloroquine-resistant malaria in Dakar, Senegal]. ( Bah, IB; Bengua, E; Diallo, S; Faye, O; Gaye, O; Victorius, A, 1990) |
| " As he required further anti-malarial prophylaxis, his marrow was prospectively tested in vitro with proguanil and its metabolite cycloguanil." | 3.68 | Prospective in vitro testing for drug-induced neutropenia in a patient requiring anti-malarial prophylaxis: confirmation of findings on exposure of patient to drug. ( French, A; Humphrey, CA; Morris, TC, 1990) |
| "We studied the relationship between exposure to malaria, the use of long-term chemoprophylaxis with chloroquine, and the prevalence of sporozoite antibodies in 446 expatriates who had lived in 7 West African countries for 6 months-41 years." | 3.68 | Effect of malaria chemoprophylaxis on the development of antibodies to Plasmodium falciparum in expatriates living in west Africa. ( Chulay, JD; Keystone, JS; Philpott, J; Reid, A; Szarfman, A; Wirtz, RA, 1990) |
| "In Eastern Thailand the increasing resistance of Plasmodium falciparum to all available antimalarial drugs prompted a reassessment of chloroquine in combination with either erythromycin or tetracycline." | 3.67 | Failure of chloroquine-erythromycin and chloroquine-tetracycline combinations in treatment of chloroquine-resistant falciparum malaria in eastern Thailand. ( Karbwang, J; Kasemsarn, P; Looareesuwan, S; Phillips, RE; Warhurst, DC; Warrell, DA; White, NJ, 1984) |
| "A determination of the sensitivity to chloroquine and to mefloquine was carried out in malaria patients of the Albert Schweitzer Hospital, Lambarene, Gabon, by using the schizont maturation test." | 3.67 | Plasmodium falciparum-malaria: resistance to chloroquine, but sensitivity to mefloquine in the Gabon. A prospective in-vitro study. ( Burchard, GD; Dietrich, M; Horstmann, RD; Wernsdorfer, WH, 1984) |
| "Mössbauer studies of rat erythrocytes infected by Plasmodium berghei malaria parasites, using 57Fe-enriched rat red blood cells, were carried out in order to determine the physical parameters which characterize the malarial pigment iron and to test the effect of the widely used antimalaria drug, chloroquine, on these parameters." | 3.67 | The malarial pigment in rat infected erythrocytes and its interaction with chloroquine. A Mössbauer effect study. ( Bauminger, ER; Ginsburg, H; Ofer, S; Yayon, A, 1984) |
| "A 16-year old girl with insulin-dependent diabetes mellitus (8 years' duration) developed tropic malaria 7 weeks after her return from Kenya despite a longtime prophylaxis using pyrimethamine and sulfadoxine (Fansidar)." | 3.67 | [Chloroquine and pyrimethamine/sulfadoxine resistant malaria tropica in a child with diabetes mellitus]. ( Bienzle, U; Burger, W; Kroll, MH; Weber, B, 1984) |
| "Chloroquine-resistant Plasmodium falciparum malaria has been described in East, Central and West Africa." | 3.67 | Probable chloroquine-resistant Plasmodium falciparum malaria in south-western Africa. ( Blumenfeld, AM; Davidson, A; Isaäcson, M; Sieling, WL, 1984) |
| "Chloroquine (CQ), the most widely used antimalarial drug, is an acidotropic agent (De Duve, 1983) which accumulates to high levels in malaria-infected erythrocytes." | 3.67 | Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine. ( Cabantchik, ZI; Ginsburg, H; Yayon, A, 1984) |
| "An extended in vivo test of the sensitivity of Plasmodium falciparum to antimalarial drugs in Nigerian children showed no evidence of resistance to chloroquine and amodiaquine." | 3.67 | The sensitivity of Plasmodium falciparum to chloroquine and amodiaquine in Ibadan, Nigeria. ( Bademosi, K; Obih, PO; Salako, LA; Sodeinde, O; Walker, O, 1984) |
| "The antimalarial drugs chloroquine and pyrimethamine were observed to afford protection to mice treated with these agents." | 3.67 | Protection against Plasmodium berghei yoelii in chloroquine- and pyrimethamine-treated mice. ( Pradhan, VR; Renapurkar, DM, 1984) |
| "In malaria-endemic areas like Nigeria, chloroquine is used frequently and extensively in the management of attacks." | 3.67 | Residual chloroquine and metabolites in man as a sequel of previous chloroquine medications: a urinary excretion study and its significance. ( Essien, EE; Ifudu, ND, 1984) |
| "A questionnaire survey was performed among 550 acutely febrile patients with malaria to determine whether pruritus accompanied chloroquine therapy when the drug was employed to suppress paroxysmal febrile attacks." | 3.67 | Chloroquine-induced pruritus among patients with malaria. ( Osifo, NG, 1984) |
| " The malarial drugs primaquine and chloroquine are used as examples of mechanism 2." | 3.67 | Theoretical aspects of enzyme induction and inhibition leading to the reversal of resistance to biocides. ( Akintonwa, DA, 1984) |
| "Chloroquine (Cq) and desethyl-chloroquine ( CqM ) levels were measured by HPLC in the blood, plasma, and erythrocytes of 9 healthy subjects under standard prophylactic treatment (100 mg/day for 10 days) and 8 malarial patients given a therapeutic regimen (10 or 25 mg/kg)." | 3.67 | [Distribution of chloroquine and desethylchloroquine in blood, plasma and erythrocytes of healthy subjects and malaria patients. Assay using HPLC]. ( Blayo, MC; Clavier, F; Deloron, P; Verdier, F, 1984) |
| " The usefulness of this type of analysis for in vitro studies of antimalarial agents was demonstrated using three such agents--cyclosporin A, chloroquine, and pyrimethamine." | 3.67 | Microscopic and flow cytophotometric analysis of parasitemia in cultures of Plasmodium falciparum vitally stained with Hoechst 33342--application to studies of antimalarial agents. ( Brun, R; Franklin, RM; Grieder, A, 1986) |
| "Racemic verapamil and close structural derivatives gallopamil and devapamil completely reverse chloroquine-resistance in falciparum malaria at 1-2 micromolar concentrations." | 3.67 | Reversal of chloroquine resistance in falciparum malaria independent of calcium channels. ( Van Dyke, K; Ye, ZG, 1988) |
| "A number of bis(benzyl)polyamine analogs were found to be potent inhibitors of both chloroquine-resistant and chloroquine-sensitive strains of the human malaria parasite Plasmodium falciparum in vitro (IC50 values = 0." | 3.67 | Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria. ( Bitonti, AJ; Bush, TL; Dumont, JA; Edwards, ML; McCann, PP; Sjoerdsma, A; Stemerick, DM, 1989) |
| "A 39-year-old Japanese male engineer who stayed in Nigeria from August 17, 1987 through January 22, 1988, presented chloroquine-resistant Plasmodium falciparum malaria." | 3.67 | [Chloroquine-resistant Plasmodium falciparum malaria confirmed by semi-micro sensitivity test for chloroquine seen in a person returned from Nigeria to Japan]. ( Kano, S; Matsuoka, Y; Obana, M; Suzuki, M; Waki, S; Yamakawa, H, 1989) |
| "To develop a malaria treatment policy for children with Plasmodium falciparum, an in vivo and in vitro chloroquine (CQ) sensitivity study was conducted in Côte d'Ivoire in September 1986." | 3.67 | Formulation of malaria treatment policy for children in Côte d'Ivoire as chloroquine resistant Plasmodium falciparum spreads into west Africa. ( Breman, JG; Davis, CE; Nguyen-Dinh, P; Peyron, FM; Saki, ZM; Soro, B; Yao, F, 1989) |
| "In vivo testing of the sensitivity of Plasmodium falciparum to chloroquine was carried out in 61 falciparum malaria patients with acute symptoms, in Eastern Sudan." | 3.67 | Chloroquine-resistant Plasmodium falciparum in eastern Sudan. ( Babiker, HA; Bayoumi, RA; Elwasila, M; Ghalib, HW; Ibrahim, SM; Karim, EA; Khider, S; Saeed, BO, 1989) |
| "Two soldiers continued weekly prophylaxis with 300 mg chloroquine base on their return to Australia from Papua New Guinea but were not protected against Plasmodium vivax malaria." | 3.67 | Plasmodium vivax resistance to chloroquine? ( Davis, DR; Hutton, DC; Rieckmann, KH, 1989) |
| "The use of Méfloquine in the prophylactic treatment of malaria has, up to now, been hampered by the standpoint adopted by the WHO, the Conseil Supérieur d'Hygiène and some specialists, for whom Méfloquine should be administered only for short stays in areas of strong chloroquine-resistance." | 3.67 | [The role of mefloquine in the prevention of malaria]. ( Lapierre, J; Périn, M; Sureau, C, 1989) |
| "The in vivo sensitivity of Plasmodium falciparum for chloroquine, quinine and pyrimethamine-sulfadoxine has been evaluated in 3 of 14 sentinel antimalarial drugs sensitivity surveillance centres between October 1986 and July 1987." | 3.67 | [Comparative efficacy of alternative treatments in Plasmodium falciparum infections in Zaire]. ( Disu, MM; Kalonji, MW; Mbudi, PK; Pela, NN, 1989) |
| "The potential therapeutic application of chloroquine-containing immunoliposomes (Fab'-lipCQ) in a Plasmodium berghei malaria model was studied." | 3.67 | Therapeutic effect of chloroquine(CQ)-containing immunoliposomes in rats infected with Plasmodium berghei parasitized mouse red blood cells: comparison with combinations of antibodies and CQ or liposomal CQ. ( Brunink, BG; Crommelin, DJ; Eling, WM; Peeters, PA, 1989) |
| "In this study, the advantage of the use of chloroquine (CQ) containing liposomes (lipCQ) over free CQ in the chemotherapy of murine malaria (Plasmodium berghei) was demonstrated." | 3.67 | Chloroquine containing liposomes in the chemotherapy of murine malaria. ( Crommelin, DJ; Eling, WM; Huiskamp, CW; Peeters, PA, 1989) |
| "9 per cent relapse rate after administration of radical treatment of primaquine / 15 mg daily for 5 days as followed under the National Malaria Eradication Programme." | 3.67 | Efficacy of 5 day radical treatment of primaquine in Plasmodium vivax cases at the BHEL industrial complex, Hardwar (U.P.). ( Dua, VK; Sharma, VP; Sinha, S, 1989) |
| "215 patients of vivax malaria were treated with chloroquine phosphate alone at the dose of 1." | 3.67 | [Field observation on the relapse pattern in patients naturally infected with vivax malaria from spring to autumn seasons in Cili County, Hunan Province]. ( Li, QJ; Liu, WJ; Yang, BL; Yuan, HA; Zhu, FH, 1989) |
| "Feeding a vitamin E-deficient diet containing 5% menhaden oil to mice affords significant protection against both a chloroquine-sensitive and a chloroquine-resistant line of the malarial parasite." | 3.67 | Menhaden-fish oil in a vitamin E-deficient diet: protection against chloroquine-resistant malaria in mice. ( Ager, AL; Levander, OA; May, RG; Morris, VC, 1989) |
| "CM 6606 differs in its mode of action from chloroquine but studies on its activity against parasites resistant to other antimalarials suggest that it may have some features in common with aminoalcohols." | 3.67 | The chemotherapy of rodent malaria. XLIV. Studies on the mode of action of CM 6606, an indolo (3,2-c) quinoline N-oxide. ( Ellis, DS; Mutambu, SL; Peters, W; Robinson, BL; Tovey, DG; Warhurst, DC, 1989) |
| "The Nigerian Federal Ministry of Health in 1987 instituted a nationwide programme to gather data on the efficacy of chloroquine in treating malaria in children as a basis for the development of a national malaria therapy policy." | 3.67 | Efficacy of chloroquine in the treatment of malaria in children under five years in Baissa (Gongola State, Nigeria). ( Daniel, HI; Molta, NB, 1989) |
| "An attempt has been made to study the dynamics in the epidemiology of a locality where the local strains of Plasmodium falciparum have developed resistance to the antimalarial chloroquine." | 3.67 | A longitudinal study of P. falciparum response to chloroquine in relation to the epidemiology. ( Chakrabarati, NK; Nagaraj, C; Narasimham, MV, 1989) |
| "Three case reports of falciparum malaria not responding to standard chloroquine therapy and necessitating the use of alternative antimalarial drugs for clinical improvement, are documented." | 3.67 | Therapeutic failure with chloroquine in Plasmodium falciparum infections; possibility of high grade resistance. ( Dharmasena, BD; Illangasekera, VL; Ranaweera, RL; Seneviratne, JK; Wijesundera, MD, 1989) |
| "Increased foreign travel and changes in the prevalence of malaria have made chloroquine more widely prescribed for prophylaxis." | 3.67 | Chloroquine overdosage in infancy: a case report. ( Loney, PD; Walling, AD, 1989) |
| " No malaria attack was observed in the group (n = 32) taking chlorproguanil and chloroquine for chemoprophylaxis." | 3.67 | [A study of the efficacy of the chemoprevention of malaria using chlorproguanil alone or in combination with chloroquine in French expatriates in Dar-es-Salaam, Tanzania]. ( Flachs, H; Havermann, K; Le Bras, J; Ringwald, P, 1989) |
| "In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h." | 3.67 | Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. ( Attanath, P; Benjasurat, Y; Karbwang, J; Looareesuwan, S; Phillips, RE; Warrell, DA; White, NJ, 1985) |
| "Standard triple-dose therapy with chloroquine (25 mg base/kg) failed to clear asexual Plasmodium falciparum parasites from the blood of 22 of 98 patients infected in various parts of Ethiopia and evaluated in Addis Ababa, a malaria-free city." | 3.67 | Chloroquine-resistant Plasmodium falciparum malaria in Ethiopia. ( Teklehaimanot, A, 1986) |
| "Two hundred and fifty-one Nigerian medical and nursing students from the University of Maiduguri Teaching Hospital completed a questionnaire on chloroquine-induced pruritus." | 3.67 | Chloroquine-induced pruritus in Nigerian medical and nursing students. ( Chugh, KS; Harries, AD, 1986) |
| "Within two months of treatment for falciparum malaria, Plasmodium vivax infections developed in 58 (33%) of 174 patients who had received a quinine or quinidine regimen and in 46 (32%) of 145 patients who had received mefloquine with inpatient follow-up of more than six weeks." | 3.67 | High rate of Plasmodium vivax relapse following treatment of falciparum malaria in Thailand. ( Bunnag, D; Chittamas, S; Harinasuta, T; Looareesuwan, S; White, NJ, 1987) |
| "A 12-year-old boy developed a phototoxic rash with subsequent progression to Stevens-Johnson syndrome due to prophylactic ingestion of antimalarials (chloroquine and sulfadoxine-pyrimethamine; Fansidar)." | 3.67 | An unusual combination of phototoxicity and Stevens-Johnson syndrome due to antimalarial therapy. ( Hönigsmann, H; Ortel, B; Sivayathorn, A, 1989) |
| " Thirty-four patients with falciparum malaria were screened for in-vitro resistance to chloroquine, mefloquine and quinine using the WHO standard micro-test." | 3.67 | Response of Kampuchean strains of Plasmodium falciparum to antimalarials: in-vivo assessment of quinine and quinine plus tetracycline; multiple drug resistance in vitro. ( Denis, MB; Giboda, M, 1988) |
| "Within the framework of its surveillance of Plasmodium falciparum chloroquine sensitivity in eight West African countries (Benin, Burkina Faso, Côte d'lvoire, Mali, Mauritany, Niger, Senegal, and Togo) the Reference Centre for Chemoresistant Malaria (CRCP) at the Organization for Coordination and Cooperation to Control Major Endemic Diseases (O." | 3.67 | [Emergence of chloroquine-resistant malaria in West Africa: the case of Sokode (Togo)]. ( Gbary, AR; Guiguemdé, TR; Ouedraogo, JB, 1988) |
| "Oral mepacrine dihydrochloride, 200 mg (158 mg of the base) six-hourly for five doses followed by 100 mg (79 mg of the base) eight-hourly for six days (half dosage for those less than or equal to 50 kg) was given to 21 patients with high-grade chloroquine-resistant falciparum malaria in eastern Thailand." | 3.67 | Mepacrine accumulation during treatment of chloroquine-resistant falciparum malaria. ( Chanthavanich, P; Edwards, G; Looareesuwan, S; Phillips, RE; Rodick, CL; Supanaranond, W; Warrell, DA, 1988) |
| "Although empirical regimens of parenteral chloroquine have been used extensively to treat severe malaria for 40 years, recent recommendations state that parenteral chloroquine should no longer be used because of potential toxicity." | 3.67 | Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations. ( Berry, C; Brown, J; Churchill, FC; Greenwood, BM; Miller, KD; White, NJ; Williams, SB, 1988) |
| "Proguanil 200mg daily and chloroquine base 300mg weekly along with maloprim 1 tablet weekly was used as malaria chemoprophylaxis for 140 Hong Kong based soliders on a seven-week jungle exercise in a holoendemic malarial area of Papua New Guinea." | 3.67 | Malaria chemoprophylaxis with a proguanil-chloroquine-maloprim combination in Papua New Guinea. ( Heap, BJ, 1988) |
| "In vivo sensitivity of Plasmodium falciparum to chloroquine was evaluated in 4 of 9 regions of Zaire in 1985 to develop a national strategy for treatment of malaria." | 3.67 | Response of children with Plasmodium falciparum to chloroquine and development of a national malaria treatment policy in Zaire. ( Breman, JG; ma-Disu, M; Moore, M; Ngimbi, NP; Paluku, KM; Roy, J; Sexton, JD; Steketee, RW; Weinman, JM, 1988) |
| "The drug of choice in the treatment of chloroquine-resistant Plasmodium falciparum malaria is parenteral quinine dihydrochloride." | 3.67 | Ineffectiveness of continuous quinidine gluconate infusion in the treatment of severe chloroquine-resistant Plasmodium falciparum malaria. ( Chan, LA; Matsuura, GK, 1988) |
| "Microsomal monooxygenases, enzymes that metabolize xenobiotics, may be responsible for the chloroquine resistance of malarial parasites." | 3.67 | Chloroquine resistance of Plasmodium berghei: biochemical basis and countermeasures. ( Chekhonadskikh, TV; Igonina, TM; Pankova, TG; Salganik, RI, 1987) |
| "Representatives of 200 urban and 200 rural households were interviewed to determine the extent and appropriateness of the use of chloroquine obtained over-the-counter for malaria prophylaxis." | 3.67 | Self-medication with chloroquine for malaria prophylaxis in urban and rural Zimbabweans. ( Gora, NP; Macheka, BM; Stein, CM, 1988) |
| " There was a decrease in spleen rate and a fall in average enlarged spleen size with increasing gestational age for women attending on a first clinic visit and before receiving chloroquine prophylaxis." | 3.67 | A longitudinal study of splenomegaly in pregnancy in a malaria endemic area in Papua New Guinea. ( Alpers, MP; Brabin, BJ; Brabin, LR; Sapau, J, 1988) |
| "In 33 children with confirmed Plasmodium falciparum malaria, the WHO Extended Field Test was employed to test the sensitivity of the parasite to chloroquine in Zaria urban area." | 3.67 | In-vivo sensitivity of Plasmodium falciparum to chloroquine in Zaria, Nigeria. ( Bhatt, GC; Lege-Oguntoye, L; Midala, TA; Werblinska, B, 1988) |
| "A new technique for assessment of in vitro growth of Plasmodium falciparum by fluoroassay was used to determine the sensitivity to chloroquine of parasites from cases of malaria imported into Japan." | 3.67 | A fluorometric sensitivity test for chloroquine in Plasmodium falciparum isolates from patients. ( Adachi, M; Suzuki, M; Takagi, T; Tamura, J; Waki, S, 1987) |
| "Using [G-3H]hypoxanthine uptake as a radioactive indicator for the growth of malarial parasites, we measured the antimalarial activity of artemisinin (Qinghaosu, QHS) against FCMSU1/Sudan strain (chloroquine-sensitive strain) and FCB K+ strain (chloroquine-resistant strain) of Plasmodium falciparum in continuous culture in vitro." | 3.67 | Effect of artemisinin (qinghaosu) and chloroquine on drug-sensitive and drug-resistant strains of Plasmodium falciparum malaria: use of [2,8-3H]adenosine as an alternative to [G-3H]hypoxanthine in the assessment of in vitro antimalarial activity. ( Van Dyke, K; Wimmer, M; Ye, ZG, 1987) |
| "To determine the effects of chloroquine phosphate (300 mg base weekly) chemoprophylaxis for malaria provided by volunteer village health helpers (VHH's), pregnant women attending antenatal clinics in Saradidi, Kenya, were examined each month." | 3.67 | Malaria chemoprophylaxis to pregnant women provided by community health workers in Saradidi, Kenya. II. Effect on parasitaemia and haemoglobin levels. ( Huong, AY; Kaseje, DC; Roberts, JM; Sempebwa, EK; Spencer, HC, 1987) |
| "Parasitaemia and antimalarial antibodies were examined from May 1983 to March 1984 in monthly samples taken from 930 pregnant women attending antenatal clinics in Saradidi, Kenya, and 317 of their infants; 104 women were taking chloroquine phosphate 300 mg base weekly for chemoprophylaxis." | 3.67 | Malaria chemoprophylaxis to pregnant women provided by community health workers in Saradidi, Kenya. III. Serologic studies. ( Collins, WE; Huong, AY; Kaseje, DC; Roberts, JM; Shehata, MG; Spencer, HC; Stanfill, PS; Turner, A, 1987) |
| "From 1981 through 1984, the response of Plasmodium falciparum to chloroquine was monitored in Saradidi, Kenya, as a part of a community-based health programme to provide treatment for malaria in each village." | 3.67 | Changing response to chloroquine of Plasmodium falciparum in Saradidi, Kenya, from 1981 to 1984. ( Brandling-Bennett, AD; Churchill, FC; Kaseje, DC; Koech, DK; Oloo, AJ; Spencer, HC, 1987) |
| "Since August 1983, several cases of chloroquine resistant malaria have been observed in caucasian adults living in the Central African Republic (CAR) despite an antimalarial prophylaxis." | 3.67 | [Status of drug resistance of Plasmodium falciparum in the Central African Republic. Results of studies carried out between 1984 and 1986]. ( Delmont, J; Faugère, B; Georges, AJ; Limbassa, J; Monges, P; Testa, J, 1987) |
| "We present two cases of Plasmodium falciparum malaria contracted in Douala despite adequate prophylaxis by Fansidar for one and by chloroquine for the other." | 3.67 | [2 cases of multiresistant Plasmodium falciparum malaria contracted in Douala with atypical clinical presentation]. ( Charmot, G; Le Bras, J; Simon, F, 1987) |
| "World areas with chloroquine-resistant falciparum malaria are progressively spreading, in Africa from East to West." | 3.67 | [A case of chloroquine-resistant malaria of type R3 originating in Cameroon]. ( Alvar, J; Barreiros, G; Benito, A; Martin-Fontelos, P; Ortiz, M, 1987) |
| "Studies on the in vivo sensitivity of Plasmodium falciparum strains to chloroquine were carried out on shrub savanna areas of Burkina Faso, West Africa and were conducted from 1982 to 1986 in asymptomatic malarial school children." | 3.67 | [Surveillance of the sensitivity of Plasmodium falciparum to chloroquine in Western Africa: value of in vivo tests using 5 and 10 mg/kg]. ( Baudon, D; Guiguemde, TR; Ouedraogo, JB, 1987) |
| "24 cases of Plasmodium falciparum malaria in a group of 73 non-immune subjects coming mostly from central Africa have been tested in vitro for chloroquine sensitivity: 5 are sensitive, 19 are resistant among whom one is also quinine-resistant." | 3.67 | [Current aspects of imported drug-resistant Plasmodium falciparum]. ( Buisson, Y; Chabiersky, M; Daly, JP; Le Bras, J; Roué, R; Saliou, P; Simon, F; Talarmin, F, 1987) |
| "Chemoprophylaxis using chloroquine (CQ) in suppressive doses has been recommended to protect pregnant women in malarious areas from the adverse effects of malaria during pregnancy." | 3.67 | In vivo response of Plasmodium falciparum to chloroquine in pregnant and non-pregnant women in Siaya District, Kenya. ( Brandling-Bennett, AD; Churchill, FC; Kaseje, DC; Schwartz, IK; Steketee, RW, 1987) |
| "We evaluated amodiaquine as a replacement drug for treating falciparum malaria in an area of Pakistani Punjab where chloroquine-resistant Plasmodium falciparum has recently emerged." | 3.67 | Amodiaquine fails to cure chloroquine resistant Plasmodium falciparum in the Punjab. ( Fox, E; Khaliq, AA; Sarwar, M; Strickland, GT, 1987) |
| "The effect of the antimalarial drug chloroquine (CQ) on the phospholipid metabolism in Plasmodium knowlesi-infected simian erythrocytes has been studied by incubating cells with different labeled precursors and various concentrations of CQ." | 3.67 | Differential effects of chloroquine on the phospholipid metabolism of Plasmodium-infected erythrocytes. ( Ancelin, ML; Philippot, JR; Thuet, MJ; Vial, HJ, 1988) |
| "A case of chloroquine-resistant falciparum malaria imported into Italy from Angola is reported." | 3.67 | [Chloroquine-resistant Plasmodium falciparum malaria imported into Italy]. ( Fossaluzza, V; Rossi, P; Schiavon, I; Tosato, F; Udina, P, 1987) |
| "The concentrations of chloroquine and desethylchloroquine in the blood of 10 healthy adult Swedish volunteers who had been taking 310 mg chloroquine base once a week for at least 8 months for malaria prophylaxis were measured." | 3.67 | Chloroquine and desethylchloroquine concentrations during regular long-term malaria prophylaxis. ( Bergqvist, Y; Hellgren, U; Rombo, L, 1987) |
| "A death from chloroquinoresistant falciparum malaria contracted by a traveller under chloroquine chemoprophylaxis during a stay in the Cameroon provides the authors with an opportunity to analyze the extension of chloroquinoresistance in Africa." | 3.67 | [A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon]. ( Beylot, J; Combe, A; Le Bras, J; Le Bras, M; Raccurt, CP; Ripert, C, 1986) |
| "The efficacy of different doses of chloroquine in suppressing patent parasitaemia was investigated in 326 children two to 12 years old, living in six villages with holoendemic malaria." | 3.67 | In vivo response of Plasmodium falciparum to different doses of chloroquine in semi-immune children in Liberia, West Africa. ( Bengtsson, E; Björkman, A; Hanson, AP; Rombo, L; Willcox, M, 1986) |
| "Six imported cases of chloroquine-resistant Falciparum malaria have been studied since October 1984." | 3.67 | Imported cases of chloroquine-resistant falciparum malaria in Iran. ( Afshar, A; Edrissian, GH; Emadi, AM; Ghorbani, M; Hajseyed-Javadi, J; Khaleghian, B; Pishva, E; Saghari, H; Shahabi, S, 1986) |
| "Chloroquine-resistant Plasmodium falciparum malaria contracted in Mozambique by a patient taking correct prophylaxis is reported." | 3.67 | Chloroquine-resistant malaria. A case report. ( Dini, GC, 1986) |
| "A case of concurrent chloroquine- and Fransidar-resistant Plasmodium falciparum malaria imported into Zimbabwe by an adult male Zimbabwean from either Malawi or Mozambique is reported." | 3.67 | Concurrent chloroquine- and Fansidar-resistant Plasmodium falciparum: an imported case into Zimbabwe. ( Dallas, AB; Mutambu, SL; Okwanga, PN; Pfumojena, JW, 1986) |
| "Seven patients (one black African and six white Europeans) developed chloroquine-resistant falciparum malaria in East Africa." | 3.67 | Chloroquine-resistant falciparum malaria from East Africa. ( Bhattacharya, DN; Hall, AP, 1986) |
| "Sixty-eight cases of vivax and 30 cases of falciparum malaria patients were treated with a combination of sulfamonomethoxine-pyrimethamine (MP tablet with 500 mg of sulfamonomethoxine and 25 mg of pyrimethamine) and the results were compared with those with chloroquine, Fansidar and quinine." | 3.67 | A combination of sulfamonomethoxine and pyrimethamine versus other drugs for the treatment of malaria. ( Ebisawa, I; Ohara, H, 1986) |
| "The protective effect of malaria chemoprophylaxis with either Fansidar (pyrimethamine-sulfadoxine) or chloroquine was estimated by determining the attack rates of Plasmodium falciparum infections acquired in Kenya and imported by U." | 3.67 | Efficacy of malaria prophylaxis in American and Swiss travelers to Kenya. ( Lobel, HO; Roberts, JM; Somaini, B; Steffen, R, 1987) |
| "Chloroquine, in a single dose of 10 mg of base/kg, was given orally to Togolese children less than 5 years of age as primary therapy for Plasmodium falciparum malaria." | 3.67 | Single-dose chloroquine therapy for Plasmodium falciparum in children in Togo, West Africa. ( Agbo, K; Breman, JG; Gayibor, A; Karsa, T; Miller, KD; Murphy, K; Roberts, JM; Sexton, JD, 1987) |
| "Mefloquine-sulphadoxine-pyrimethamine (MSP) in combination has proved effective against multiple-drug-resistant falciparum malaria, but nothing is known about mefloquine absorption when it is given in this formulation." | 3.67 | Plasma and whole blood mefloquine concentrations during treatment of chloroquine-resistant falciparum malaria with the combination mefloquine-sulphadoxine-pyrimethamine. ( Back, DJ; Karbwang, J; Looareesuwan, S; Molyneux, ME; Nagachinta, B; Phillips, RE; Warrell, DA; Wattanagoon, Y, 1987) |
| "Urinary excretion of chloroquine and its desethyl-metabolite was monitored for up to 395 days after the last dose of oral chloroquine (300 mg base) taken once weekly for 10 weeks as malaria prophylaxis." | 3.67 | Chloroquine excretion following malaria prophylaxis. ( Alván, G; Grahnén, A; Gustafsson, LL; Lindström, B, 1987) |
| " These antibody bearing liposomes have now been found quite effective as vehicles for delivering the antimalarial drug, chloroquine, to erythrocytes in Plasmodium berghei-infected mice." | 3.67 | Functional drug targeting to erythrocytes in vivo using antibody bearing liposomes as drug vehicles. ( Agrawal, AK; Gupta, CM; Singhal, A, 1987) |
| "A community-based malaria control programme in Saradidi, Kenya provided chloroquine treatment for malaria in each village beginning in May 1982." | 3.67 | Consumption of chloroquine phosphate provided for treatment of malaria by volunteer village health workers in Saradidi, Kenya. ( Huong, AY; Kaseje, DC; Roberts, JM; Spencer, HC, 1987) |
| "Chloroquine prophylaxis for malaria was available free of charge to pregnant women in Saradidi, Kenya." | 3.67 | Malaria chemoprophylaxis to pregnant women provided by community health workers in Saradidi, Kenya. I. Reasons for non-acceptance. ( Kaseje, DC; Sempebwa, EK; Spencer, HC, 1987) |
| "A fatal case of Stevens-Johnson syndrome associated with Fansidar and chloroquine is reported in a 5-year-old boy." | 3.67 | Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine. ( Bamber, MG; Elder, AT; Gray, JA; Minns, RA, 1986) |
| "Administration of chloroquine after major surgery is indicated in malaria endemic areas." | 3.67 | Chloroquine administration for malaria suppression after abdominal surgery. ( Betschart, B; Burnier, E; Mwakilasa, A; Schweizer, W; Stahel, E; Stutz, P; Tanner, M, 1987) |
| "A village-based programme of presumptive treatment of fever, using voluntary village aides to dispense oral chloroquine or amodiaquine, was established in 1982 by the Papua New Guinea Institute of Medical Research (PNG IMR) in 35 rural villages or hamlets near Madang, on the north coast of PNG." | 3.67 | The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health. ( Alpers, MP; Heywood, PF; Jolley, DJ; Moir, JS; Tulloch, JL; Vrbova, H, 1985) |
| "Antimalarial activity of chloroquine, quinine, mefloquine and halofantrine against 33 strains of P." | 3.67 | Antimalarial drug susceptibility testing of Plasmodium falciparum in Thailand using a microdilution radioisotope method. ( Boudreau, EF; Pang, LW; Pavanand, K; Webster, HK; Yongvanitchit, K, 1985) |
| "A prospective study of imported chloroquine-resistant falciparum malaria in the Netherlands is described." | 3.67 | Chloroquine-resistant falciparum malaria imported into the Netherlands. ( de Geus, A; Wetsteyn, JC, 1985) |
| "Chloroquine (CQ) accumulates in the acidic food vacuole of intraerythrocytic malaria parasites (Plasmodium falciparum) by virtue of its weak base properties." | 3.67 | Susceptibility of human malaria parasites to chloroquine is pH dependent. ( Cabantchik, ZI; Ginsburg, H; Yayon, A, 1985) |
| "One hundred cases of slide-confirmed Plasmodium falciparum malaria admitted to the San Lazaro Hospital, Manila, Philippines were screened for in vitro resistance to chloroquine, quinine, amodiaquine and mefloquine using the microtechnique." | 3.67 | Studies of resistance to chloroquine, quinine, amodiaquine and mefloquine among Philippine strains of Plasmodium falciparum. ( Alcantara, AK; Buck, RL; Rodriguez, CS; Smrkovski, LL; Uylangco, CV, 1985) |
| "A Venda child with Plasmodium falciparum malaria had a recurrence of illness 3 weeks after an adequate course of chloroquine." | 3.67 | In vivo and in vitro chloroquine-resistant falciparum malaria in Venda. A case report. ( Bac, DJ; Cox, GA; Isaäcson, M, 1985) |
| " falciparum malaria was cultured in vitro in the presence of sera from patients with cerebral malaria, meningitis and also after chloroquine administration." | 3.67 | The development and ultrastructure of Plasmodium falciparum damaged in vitro by human "crisis" sera and by chloroquine. ( Butcher, GA; Clancy, RL; Cowen, N; Maxwell, L; Stace, JD, 1985) |
| " falciparum, parasitemia recurred following treatment with the candidate antimalarial drug enpiroline." | 3.67 | Mefloquine failure in a case of falciparum malaria induced with a multidrug-resistant isolate in a non-immune subject. ( Canfield, CJ; Cosgriff, TM; Pamplin, CL; Willet, GP, 1985) |
| "National malaria surveillance data were reviewed in an analysis of the epidemiological impact of the transmission of chloroquine-resistant Plasmodium falciparum in Africa on malaria in the United States." | 3.67 | Recent trends in the importation of malaria caused by Plasmodium falciparum into the United States from Africa. ( Campbell, CC; Lobel, HO; Roberts, JM; Schwartz, IK, 1985) |
| "An American Peace Corps volunteer contracted chloroquine-resistant Plasmodium falciparum malaria while serving in Malawi and taking regular chloroquine prophylaxis." | 3.67 | Chloroquine-resistant falciparum malaria in northern Malawi. ( Ainsworth, B; Breman, JG; Patchen, LC; Teklehaimanot, A; Wolfe, MS, 1985) |
| "Chloroquine-resistant plasmodium falciparum malaria has been described in many parts of the world, including Africa as far south as south-western Africa." | 3.67 | Chloroquine-resistant Plasmodium falciparum malaria in South Africa. A case report. ( Sieling, WL; Visagie, NJ, 1985) |
| "Blood samples from 77 patients with Plasmodium falciparum malaria resident in the Natal/Kwazulu area, were tested for chloroquine resistance by an in vitro microtechnique; 6 of these patients were infected by asexual parasites which proved resistant in varying degrees to chloroquine." | 3.67 | In vitro chloroquine-resistant Plasmodium falciparum malaria in the Natal/Kwazulu area. ( Herbst, JM; Joubert, SM; Taylor, LA, 1985) |
| "Chloroquine, a well-known anti-malarial and anti-inflammatory agent, was studied with respect to its effect on the serum complement system." | 3.67 | Effects of chloroquine on the serum complement system. ( Chakrabarty, AK; Chopra, S; Saha, K; Sen, P, 1985) |
| "An alpha-santonin-derived cyclic peroxide (7) related to qinghaosu (1) has been synthesized and tested for antimalarial activity in vitro against the chloroquine-resistant (Smith) isolates of Plasmodium falciparum as well as in vivo against Plasmodium berghei in mice and was found to be devoid of activity." | 3.67 | Antimalarial agents. 1. alpha-Santonin-derived cyclic peroxide as potential antimalarial agent. ( Fukamiya, N; Kiyokawa, H; Lee, KH; Musallam, HA; Pick, RO; Tani, S, 1985) |
| "The sensitivity level of Plasmodium falciparum isolates to chloroquine and the activity of six other antimalarials were studied in the different climatic zones of Madagascar in 1983." | 3.67 | Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs. ( Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA, 1985) |
| "In eastern Thailand, falciparum malaria is highly chloroquine-resistant and is quickly becoming quinine-resistant." | 3.67 | Failure of large-dose erythromycin in combination with a standard dose of chloroquine or quinine in the treatment of human falciparum malaria. ( Boudreau, EF; Childs, GE; Pang, LW; Somutsakorn, P; Supanantalerk, C; Webster, HK, 1985) |
| " Six Papua New Guinean children under 9 years of age developed herpes zoster following an episode of malaria, due to Plasmodium falciparum or Plasmodium vivax which was treated with chloroquine." | 3.67 | Herpes zoster in children following malaria. ( Cook, IF, 1985) |
| "Several drugs are used for malaria chemoprophylaxis: 4 amino-quinolines, antifolics, combinations of sulfonamides and antifolics, and new anti-malarial agents, including mefloquine." | 3.67 | [Malaria chemoprophylaxis. Resistance problems]. ( Danis, M; Gentilini, M, 1985) |
| "A cohort of 169 births to women who were exposed throughout pregnancy to chloroquine 300 mg base once a week for chemosuppression of malaria was studied." | 3.67 | Safety of chloroquine in chemosuppression of malaria during pregnancy. ( Cordero, JF; Wolfe, MS, 1985) |
| "The efficacy of chloroquine and pyrimethamine as malaria chemoprophylactics was investigated in young Nigerian children." | 3.67 | A comparison of chloroquine and pyrimethamine as malaria chemoprophylactics in young Nigerian children. ( Akintunde, A; Attai, ED; Bartlett, A; Bidwell, DE; Bradley, AK; Bradley-Moore, AM; Fleming, AF; Greenwood, BM; Kirkwood, BR; Voller, A, 1985) |
| "The authors report a case of Plasmodium falciparum malaria acquired in Kenya by a French tourist under correct chloroquine prophylaxis." | 3.66 | [Plasmodium falciparum malaria acquired in Kenya with type II or type III resistance to amino-4-quinolines]. ( Becq-Giraudon, B; Bonneau, D; Galenne, B; Jacquemin, JL; Poncin, E, 1983) |
| "Two tourists from Kenya with falciparum malaria had an R1-resistance against chloroquine (WHO-extended field test, no in-vitro test)." | 3.66 | [Drug-resistant malaria in East Africa]. ( Diesfeld, HJ; Kroeger, A, 1983) |
| "The initial rates of uptake of L-tryptophan into normal human red blood cells and into cells infected by the malarial parasite Plasmodium falciparum in vitro, were investigated." | 3.66 | Uptake of L-tryptophan by erythrocytes infected with malaria parasites (Plasmodium falciparum). ( Ginsburg, H; Krugliak, M, 1983) |
| "A case of chloroquine-resistant falciparum malaria in a non-immune Swiss tourist is described." | 3.66 | [A case of chloroquine-resistant tropical malaria from eastern Africa (Kenya)]. ( Gorecka, M; Reber-Liske, R; Stuby, K; von Schulthess, F, 1983) |
| "The first two cases from East Africa of RII chloroquine- and Fansidar-resistant falciparum malaria are described." | 3.66 | Combined chloroquine/Fansidar-resistant falciparum malaria appears in East Africa. ( Hess, U; Jones, M; Timmermans, PM, 1983) |
| "Chloroquine, quinine, quinacrine and related drugs are effective antimalarial agents only against parasites that degrade haemoglobin." | 3.66 | Mode of action of antimalarial drugs. ( Fitch, CD, 1983) |
| "A case is reported of Plasmodium falciparum malaria from East Africa resistant to chloroquine in the in vivo test at the RII level." | 3.66 | RII-RIII chloroquine resistant Plasmodium falciparum malaria from East Africa: studies of the in vivo and in vitro response to chloroquine. ( Black, F; Fogh, S; Jepsen, S; Peterslund, N, 1983) |
| "Data concerning 11 cases of cerebral malaria treated with high doses of chloroquine base (18mg/kg/day) are reported." | 3.66 | Cerebral malaria treated with high doses of chloroquine. ( Nuti, S; Savioli, L, 1983) |
| "A malaria prophylaxis programme for 100 000 children in one rural district of Tanzania was carried out under the very favourable conditions of 1) a government genuinely committed to rural public health, 2) a well organized system of village government for distribution of the drug to children, and 3) free chloroquine supplied without interruption by WHO to the project area." | 3.66 | Failure to participate in a malaria chemosuppression programme: North Mara, Tanzania. ( Lwihula, G; MacCormack, CP, 1983) |
| "Twelve children with acute falciparum malaria were treated with 25 mg/kg chloroquine orally in three divided doses at 24 h intervals." | 3.66 | Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria. ( Adeyokunnu, AA; Alvan, G; Dawodu, AH; Salako, LA; Walker, O, 1983) |
| "1 Ten children with Plasmodium falciparum malaria were treated with 25 mg/kg chloroquine over 3 days and observed for 7 days." | 3.66 | Kinetics of the uptake and elimination of chloroquine in children with malaria. ( Adelusi, SA; Dawodu, AH; Salako, LA, 1982) |
| "Bovine serum albumin and preparations of cell sap from malaria parasites and normal erythrocytes were tested for ability to protect cellular membranes against the toxicity of ferriprotoporphyrin IX (FP) and a chloroquine-FP complex." | 3.66 | Ferriprotoporphyrin IX binding substances and the mode of action of chloroquine against malaria. ( Banyal, HS; Fitch, CD, 1982) |
| "Since 1978 several cases of chloroquine-resistant falciparum malaria have been reported from East Africa (Petterson et al." | 3.66 | Fansidar-resistant Plasmodium falciparum infection from Tanzania. ( Meuwissen, JH; Vleugels, MP; Wetsteyn, JC, 1982) |
| " falciparum malaria (two resistant to chloroquine therapy), one with treated and apparently cured P." | 3.66 | Diminished red blood cell deformability in uncomplicated human malaria. A preliminary report. ( Ambrus, JL; DeSouza, JM; Lee, MV; Lee, RV, 1982) |
| "Thirty-five children with Plasmodium falciparum malaria were treated with 25 mg/kg chloroquine over three days and observed for seven days during which blood films were examined daily for malaria parasites." | 3.66 | Chloroquine sensitivity of Plasmodium falciparum in Ibadan, Nigeria. ( Adelusi, SA; Aderounmu, AF; Salako, LA, 1980) |
| "Evidence of resistance ot chloroquine was found in 13 out of 14 children from the East New Britain Province of Papua New Guinea, with Plasmodium falciparum malaria." | 3.66 | Chloroquine resistant Plasmodium falciparum malaria in East New Britain, Papua New Guinea. ( Tulloch, A, 1980) |
| "The prevalence of chloroquine-resistant falciparum malaria was determined for humans living at 28 different sites in the Brazilian Amazon." | 3.66 | Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon. ( Ferraroni, JJ; Hayes, J; Speer, CA; Suzuki, M, 1981) |
| " The second patient acquired falciparum malaria inspite of chloroquine prophylaxis and was admitted with a thrombocytopenia of 24 000 mm3." | 3.66 | [Think of malaria!]. ( Schreiber, W, 1981) |
| " falciparum malaria contracted in Thailand, the course of the disease under treatment suggested resistance to both chloroquine and pyrimethamine-sulfadoxine, as well as reduced sensitivity to quinine." | 3.66 | [Plasmodium falciparum malaria resistant to polychemotherapy. Usefulness of pathogen culture (author's transl)]. ( Bastin, R; Charmot, G; Dournon, E; Frottier, J; Le Bras, J, 1981) |
| "During an outbreak of urban malaria in Choluteca, Honduras, the response of local isolates of Plasmodium falciparum to chloroquine was assessed." | 3.66 | Assessment of chloroquine sensitivity of Plasmodium falciparum in Choluteca, Honduras. ( Campbell, CC; Hobbs, JH; Nguyen-Dinh, P, 1981) |
| "Doxycycline in a single dose was found to be a valuable drug in the treatment of chloroquine-resistant falciparum malaria." | 3.66 | Doxycycline in the treatment of falciparum malaria among aborigine children in West Malaysia. ( Ponnampalam, JT, 1981) |
| "Plasmodium falciparum malaria was treated in 82 children with 25 mg/kg chloroquine orally over three days." | 3.66 | Chloroquine sensitivity of Plasmodium falciparum in Ibadan, Nigeria: II. Correlation of in vitro with in vivo sensitivity. ( Aderounmu, AF; Salako, LA; Walker, O, 1981) |
| "At present the basic antimalarial drugs are still the 4-aminoquinolines chloroquine and amodiaquine, the combinations of antifol compounds (such as pyrimethamine and sulfadoxine = Fansidar), and quinine." | 3.66 | [Current therapy and prevention of malaria and perspectives for the future]. ( Markwalder, K, 1982) |
| "The sensitivity of Plasmodium falciparum strains to chloroquine was tested in one locality in the north-east of the United Republic of Tanzania, where a chloroquine-medicated salt project has been implemented for chemosuppression for many years, and where large amounts of the drug have been available during the last decade for the treatment of malaria infections." | 3.66 | Incipient resistance of Plasmodium falciparum to chloroquine among a semi-immune population of the United Republic of Tanzania. 1. Results of in vivo and in vitro studies and of an ophthalmological survey. ( Almeida Franco, J; Grab, B; Grab, D; Horst, HI; Joia, H; Onori, E; Payne, D, 1982) |
| "A case of Plasmodium falciparum malaria resistant to chloroquine occurring in a patient taking Fansidar (a combination of pyrimethamine and sulphadoxine) regularly as prophylaxis is reported." | 3.66 | Drug-resistant malaria in Africa. A case report and review of the problem and treatment. ( Halkett, JA; Nieuwveld, RW; Spracklen, FH, 1982) |
| " In developing countries, malaria among other diseases is a frequent indicator of chloroquine administration." | 3.66 | Chloroquine psychosis: a chemical psychosis? ( Mohan, D; Mohandas, E; Rajat, R, 1981) |
| "Two cases of chloroquine-resistant Plasmodium falciparum malaria have been reported from eastern Papua New Guinea in order to alert the medical profession about the spread of resistant strains throughout that territory." | 3.66 | The spread of chloroquine-resistant falciparum malaria in Papua New Guinea. ( Simpson, M; Williams, P, 1978) |
| "A case of chloroquine-resistant Plasmodium falciparum malaria in a non-immune male is reported." | 3.66 | Chloroquine-resistant Plasmodium falciparum malaria in Kenya. ( Effersøe, P; Fogh, S; Jepsen, S, 1979) |
| "A 42-year-old hospital worker had a recrudescence of falciparum malaria after chloroquine therapy." | 3.66 | Possible chloroquine-resistant Plasmodium falciparum in Nigeria. ( Eke, RA, 1979) |
| "A review of chloroquine and sulfa-antifol combination treated falciparum malaria patients revealed a high incidence of chloroquine-resistance, wither R1 or R2, in patients infected in Southeast Asia or Oceania." | 3.66 | Chemotherapy of falciparum malaria: regional differences in responsiveness to treatment. ( Ebisawa, I; Muto, T; Tanabe, S, 1979) |
| "Chloroquine is considered essentially nontoxic when used for the chemosuppression of malaria, but gastrointestinal upsets, headache, blurring of vision, pruritus, and uritcaria may occur during chloroquine therapy." | 3.66 | Extrapyramidal syndrome following chloroquine therapy. ( Singh, M; Singhi, P; Singhi, S, 1979) |
| "As part of the search for new antimalarial drugs, a screening program was developed using sensitive and chlorguanide triazine (CGT, cycloguanil) resistant strains of the folate-requiring bacteria, Streptococcus faecium durans, Lactobacillus casei, and Pediococcus cerevisiae." | 3.65 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. ( Genther, CS; Smith, CS, 1977) |
| "Chloroquine resistance has arisen in both human and murine forms of malaria." | 3.65 | Host heme catabolism in drug-sensitive and drug-resistant malaria. ( Berger, E; Eaton, JW; Eckman, JR; Engel, RR; Modler, S, 1977) |
| "Attention has once again been directed to the very uncomfortable itching following chloroquine chemotherapy of malaria in about 8% of the Nigeria population." | 3.65 | The practical and therapeutic implications of chloroquine-induced itching in tropical Africa. ( Olatunde, A, 1977) |
| "The in vivo response of Plasmodium falciparum to the WHO single test dose (10 mg/kg body weight) of chloroquine base was examined in Ethiopia at four localities where malaria was meso- or hyperendemic." | 3.65 | Chloroquine sensitivity of Plasmodium falciparum in Ethiopia. I. Results of an in vivo test. ( Armstrong, JC; Asfaha, W; Palmer, TT, 1976) |
| "The infectivity of 25 falciparum malaria patients for Anopheles balabacensis and Anopheles minimus, before and after chloroquine therapy, was studied in central Thailand." | 3.65 | Infectivity of falciparum malaria patients for anopheline mosquitoes before and after chloroquine treatment. ( Gould, DJ; Noeypatimanondh, S; Wilkinson, RN, 1976) |
| "Chloroquine and amodiaquine are demonstrably still the most reliable drugs for the treatment of malaria, except in the south east Asia area, and in parts of south and central America where an altered sensitivity of falciparum plasmodia has been confirmed." | 3.65 | [Chemotherapy and chemoprophylaxis of malaria (author's transl)]. ( Bruce-Chwatt, LJ, 1976) |
| "Clindamycin, a semi-synthetic antibiotic of the lincomycin family, at a dose of 450 mg eight-hourly for three days in adults cured five out of 10 patients moderately ill with chloroquine-resistant falciparum malaria." | 3.65 | Falciparum malaria semi-resistant to clindamycin. ( Doberstyn, EB; Hall, AP; Nanokorn, A; Sonkom, P, 1975) |
| "Evidence is presented of the chloroquine-resistance in Plasmodium falciparum in West Irian and East Kalimantan as shown by clinical observation and quantitative parasite counts in two patients hospitalized in Tokyo where no natural transmission of malaria occurs." | 3.65 | Chloroquine resistance of Plasmodium falciparum in West Irian and East Kalimantan. ( Ebisawa, I; Fukuyama, T, 1975) |
| "A female patient with Plasmodium falciparum malaria apparently resistant to chloroquine is descirbed." | 3.65 | Probable chloroquine-resistant Plasmodium falciparum malaria from Mozambique A case report. ( Bhoola, RL; Pillay, N, 1975) |
| "The efficacy of chloroquine in the treatment of falciparum malaria was studied in two villages in Northeast Thailand, an area endemic for chloroquine-resistant falciparum infections." | 3.65 | Longitudinal malaria studies in rural Northeast Thailand. Chloroquine treatment of falciparum malaria infections. ( Gresso, WE; Segal, HE; Thiemanun, W, 1975) |
| "Mass drug administration was introduced in Syria to supplement DDT spraying after the main malaria vector Anopheles sacharovi had developed considerable resistance to the insecticide." | 3.65 | Experience with mass drug administration as a supplementary attack measure in areas of vivax malaria. ( Onori, E, 1972) |
| "During the course of antimalarial screening, it was discovered that sulfamethoxydiazine, a long-acting sulfanilamide extensively used in genitourinary tract infections, not only was effective against Plasmodium berghei infections in mice when administered alone but also was active when used in combination with chloroquine, in effect making it possible to use half as much of the latter drug as normally required to achieve the same results." | 3.65 | Chemotherapeutic activity of combination doses of chloroquine, pyrimethamine, and sulfamethoxy-diazine, a long-acting sulfanilamide, against Plasmodium berghei infections in mice. ( Berberian, DA; Slighter, RG, 1973) |
| "Development of resistance to chloroquine in rodent malaria is inhibited by giving this compound together with a potentiating mixture of pyrimethamine and sulfadoxine but this does not prevent the development of resistance to the last two compounds." | 3.65 | Prevention of drug resistance in rodent malaria by the use of drug mixtures. ( Peters, W, 1974) |
| " Eleven volunteers received chloroquine in usually curative doses on a three-day schedule during acute clinical malaria attacks." | 3.64 | STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM THAILAND. ( ALVING, AS; BREWER, GJ; MILLAR, JW; POWELL, RD, 1964) |
| "Malaria and its local vector, Anopheles darlingi, were eradicated from the coastlands and near interior of Guyana by DDT house-spraying in 1945-51." | 3.64 | Interruption of malaria transmission by chloroquinized salt in Guyana, with observations on a chloroquine-resistant strain of Plasmodium falciparum. ( Giglioli, G; Ramjattan, S; Rutten, FJ, 1967) |
| "The authors present the results of a study carried out to determine the efficacy of chloroquine- and pyrimethamine-salt mixtures as a suppressive against sporozoite-induced vivax malaria (Chesson strain)." | 3.63 | Chloroquine or pyrimethamine in salt as a supressive against sporozoite-induced vivax malaria (Chesson strain). ( BURGESS, RW; COATNEY, GR; MICKELSEN, O; PIRKLE, CI; YOUNG, MD, 1958) |
| "Methods to fight malaria are being diversified, including the use of mosquito nets, the target candidate profiles (TCPs) and target product profiles (TPPs) of medicine for malarial venture (MMV) strategy, the search for newer and potent drugs that could reverse chloroquine resistance, and the use of adjuvants such as rosiglitazone and sevuparin." | 3.01 | Recent developments in antimalarial drug discovery. ( Habarurema, G; Hahirwa, I; Katembezi, AN; Kayitare, E; Kayumba, PC; Mpenda, M; Muganga, R; Mukazayire, MJ; Mukiza, J; Nkuranga, JB; Nyandwi, JB; Olawode, EO; Umumararungu, T, 2023) |
| "Malaria is a parasitic disease with the highest morbidity and mortality worldwide." | 2.82 | Action mechanisms of metallic compounds on Plasmodium spp. ( Brenda, CT; Marcela, RL; Nelly, LV; Norma, RF; Teresa I, F, 2022) |
| "Prevention and treatment of malaria depend on the species and the drug sensitivity of parasites from the region of acquisition." | 2.82 | Diagnosis, Treatment, and Prevention of Malaria in the US: A Review. ( Daily, JP; Khan, N; Minuti, A, 2022) |
| "Chloroquine serves as a drug of choice, with primaquine as a radical cure." | 2.82 | Global scenario of Plasmodium vivax occurrence and resistance pattern. ( Kaur, D; Sehgal, R; Sinha, S, 2022) |
| "Intermittent preventive treatment in pregnancy has not been evaluated outside of Africa." | 2.80 | Sulphadoxine-pyrimethamine plus azithromycin for the prevention of low birthweight in Papua New Guinea: a randomised controlled trial. ( Bardaji, A; Betuela, I; Hanieh, S; Kongs, C; Lufele, E; Menendez, C; Mueller, I; Ome-Kaius, M; Robinson, LJ; Rogerson, SJ; Rosanas-Urgell, A; Samol, P; Schofield, L; Siba, P; Singirok, D; Suen, CS; Sui, D; Umbers, AJ; Unger, HW; Wangnapi, RA; Wapling, J, 2015) |
| "Malaria in pregnancy is one of the most common preventable causes of maternal and neonatal morbidity and mortality in sub-Saharan Africa." | 2.78 | Creative solutions to extraordinary challenges in clinical trials: methodology of a phase III trial of azithromycin and chloroquine fixed-dose combination in pregnant women in Africa. ( Chandra, RS; Duparc, S; Orazem, J; Robbins, J; Ubben, D; Vandenbroucke, P, 2013) |
| "Birth weight was analyzed through multivariate linear and logistic regressions." | 2.73 | The importance of the period of malarial infection during pregnancy on birth weight in tropical Africa. ( Barro, D; Cot, M; Cottrell, G; Mary, JY, 2007) |
| "5% improvement in the accumulated proportion of patients (1) treated, (2) treated within 24h of illness onset, (3) treated with the recommended antimalarials, (4) treated at an adequate dosage and (5) treated for the correct duration." | 2.73 | Home-based management of fever and malaria treatment practices in Uganda. ( Nsungwa-Sabiiti, J; Ogwal-Okeng, J; Pariyo, G; Peterson, S; Petzold, MG; Tomson, G, 2007) |
| "Self-reported CQ treatment of fever episodes at home as well as referrals to health centres increased over the study period." | 2.73 | Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial. ( Becher, H; Coulibaly, B; Eriksen, J; Gustafsson, L; Jahn, A; Kouyaté, B; Mueller, O; Sauerborn, R; Somé, F; Tomson, G, 2008) |
| "Malaria is an endemic disease, prevalent in tropical and subtropical regions which cost half of million deaths annually." | 2.72 | An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins. ( Hoda, N; Madhav, H, 2021) |
| "The strategy of intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) was also addressed." | 2.72 | Drug treatment and prevention of malaria in pregnancy: a critical review of the guidelines. ( Al Khaja, KAJ; Sequeira, RP, 2021) |
| " Within a decade of its introduction, reports of the side effects associated with its long-term use surfaced." | 2.72 | Mefloquine as a prophylaxis for malaria needs to be revisited. ( Ahmad, SS; Rahi, M; Ranjan, V; Sharma, A, 2021) |
| " The median relative bioavailability of dihydroartemisinin (DHA), the active antimalarial metabolite of ARS, was higher in the low-dose i." | 2.70 | Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria. ( Agbenyega, T; Agranoff, D; Appiah, JA; Bedu-Addo, G; Krishna, S; Mansor, SM; Navaratnam, V; Owusu-Ofori, AK; Planche, T; Ramanathan, S; Woodrow, C, 2001) |
| "Malaria is a major cause of morbidity and mortality among children under five in sub-Saharan Africa." | 2.70 | Improving adherence to malaria treatment for children: the use of pre-packed chloroquine tablets vs. chloroquine syrup. ( Agyepong, IA; Ansah, EK; Evans, DB; Gyapong, JO, 2001) |
| " Despite the dosage employed, the frequency and duration of use, and excretion primarily through the bowels as the active parent compound, primaquine appeared to have little or no significant effect against a variety of common intestinal parasites." | 2.69 | Intestinal parasite infections after extended use of chloroquine or primaquine for malaria prevention. ( Basri, H; Fryauff, DJ; Jones, TR; Mouzin, E; Prodjodipuro, P; Subianto, B; Widjaja, H, 1998) |
| "Chloroquine was given under observation at a weekly oral dose of 300 mg." | 2.68 | Increase of birth weight following chloroquine chemoprophylaxis during the first pregnancy: results of a randomized trial in Cameroon. ( Breart, G; Cot, M; Esveld, M; Etya'ale, D; Le Hesran, JY; Miailhes, P, 1995) |
| "Chloroquine has been reported to antagonise the anti-parasitic action of quinine against Plasmodium falciparum in vitro." | 2.67 | Efficacy of quinine for falciparum malaria according to previous chloroquine exposure. ( Mansor, S; Molyneux, ME; Taylor, TE; Thomas, CG; Wirima, JJ, 1991) |
| "Malaria is a threat to human mankind and kills about half a million people every year." | 2.66 | Insights in Chloroquine Action: Perspectives and Implications in Malaria and COVID-19. ( de Souza, EE; Guimarães, LMF; Krüger, A; Lameu, C; Pillat, MM; Ulrich, H; Wrenger, C, 2020) |
| "Clinical malaria was documented significantly less frequently in protected children than in control children, and only 9% of random blood films obtained from protected children were positive for Plasmodium falciparum while 41% of random blood films from control children were positive for this parasite." | 2.66 | Malaria chemoprophylaxis with chloroquine in young Nigerian children. I. Its effect on mortality, morbidity and the prevalence of malaria. ( Bartlett, A; Bidwell, DE; Bradley, AK; Bradley-Moore, AM; Gilles, HM; Greenwood, BM; Kirkwood, BR; Voller, A, 1985) |
| "Malaria is a life threatening disease caused by microscopic parasites called Plasmodium that are transmitted to human beings by mosquitoes." | 2.61 | New dimensions in the field of antimalarial research against malaria resurgence. ( Azad, CS; Nainwal, LM; Narula, AK, 2019) |
| "Malaria and cancer are chronic diseases." | 2.61 | Ferrocene-Based Compounds with Antimalaria/Anticancer Activity. ( Aderibigbe, BA; Peter, S, 2019) |
| "Treatment of malaria has involved chemotherapy since 168 BC, with the most prevalent and successful forms using plant alkaloids." | 2.55 | The "pushmi-pullyu" of resistance to chloroquine in malaria. ( Callaghan, R; Skrzypek, R, 2017) |
| "The discovery of new drugs to treat malaria is a continuous effort for medicinal chemists due to the emergence and spread of resistant strains of Plasmodium falciparum to nearly all used antimalarials." | 2.52 | From hybrid compounds to targeted drug delivery in antimalarial therapy. ( Capela, R; Lopes, F; Magalhães, J; Miranda, D; Moreira, R; O'Neill, PM; Oliveira, R; Perry, MJ, 2015) |
| " Identified articles were included in the review if the study had at least one group that reported at least one pharmacokinetic parameter of interest in pregnant women." | 2.47 | Pharmacokinetics of antimalarials in pregnancy: a systematic review. ( Ensom, MH; Wilby, KJ, 2011) |
| "Malaria is the world's most important parasitic infection ranking among the major health and developmental challenges." | 2.44 | Current malaria status and distribution of drug resistance in East and Southeast Asia with special focus to Thailand. ( Congpuong, K; Na-Bangchang, K, 2007) |
| "Prophylaxis and intermittent treatment with antimalarial drugs reduce clinical malaria and severe anaemia in preschool children." | 2.43 | Chemoprophylaxis and intermittent treatment for preventing malaria in children. ( Garner, P; Meremikwu, MM; Omari, AA, 2005) |
| "Chloroquine resistance has been genetically linked to mutations in a parasite protein (PfCRT) that might confer resistance by inhibiting chloroquine accumulation in infected erythrocytes." | 2.42 | Can a proteomics strategy be used to identify the anti-malarial activity of chloroquine? ( Petri, WA, 2003) |
| "Malaria is frequently a deadly disease, particularly in tropical countries of the world where this protozoan infection is endemic." | 2.41 | Malaria: a rising incidence in the United States. ( Broder, JS; Colletti, JE; Geroff, AJ; Grundmann, KA; Hanna, JR; Jerrard, DA; Mattu, A, 2002) |
| "Malaria is a particularly important problem in the southeast Anatolia region of Turkey." | 2.41 | Spontaneous rupture of malarial spleen: two case reports and review of literature. ( Aldemir, M; Büyükbayram, H; Kara , IH; Keles, C; Tacyildiz, IH; Yagmur, Y, 2000) |
| " The latter is defined as regular intake of antimalarial drugs in subtherapeutic dosage in order to suppress the development of clinical disease." | 2.41 | [Malaria--chemoprophylaxis 2001]. ( Beck, B; Blum, J; Funk, M; Furrer, H; Genton, B; Hatz, FR; Holzer, B; Loutan, L; Markwalder, K; Raeber, PA; Schlagenhauf, P; Siegl, G; Steffen, R; Stürchler, D; Wyss, R, 2001) |
| "Chloroquine treatment causes the activity of the catalyst to decrease by 80 to 90 percent." | 2.40 | Involvement of heme in the antimalarial action of chloroquine. ( Fitch, CD, 1998) |
| "Chloroquine is still the treatment of choice in most cases of P." | 2.39 | [Current malaria management in Switzerland]. ( Hatz, CF, 1994) |
| " Similarly, evaluation of the pharmacokinetic properties of halofantrine has led to the demonstration that poor and erratic absorption could be just as likely to explain therapeutic failure as resistance of the parasite to effects of this drug." | 2.39 | Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations. ( Edwards, G; Ward, SA; Winstanley, PA, 1994) |
| "malariae are sensitive to the current antimalarial drugs." | 2.39 | [Malaria and drug resistance]. ( Kager, PA; Wetsteyn, JC, 1996) |
| "Symptoms of malaria are fever, chills, headache, and malaise." | 2.39 | The treatment of malaria. ( White, NJ, 1996) |
| " The shorter half-life of S(+)-chloroquine appears secondary to its faster clearance." | 2.39 | Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements. ( Ducharme, J; Farinotti, R, 1996) |
| "In both areas, malaria is stable and the inhabitants acquire a high immunity before the age of ten; most of the severe cases touch children below 10." | 2.38 | [Epidemiological stratification of malaria in Madagascar]. ( Aknouche, F; Blanchy, S; Laventure, S; Mouchet, J; Rajaonarivelo, E; Rakotonjanabelo, A; Ranaivoson, G; Rossella, M, 1993) |
| "Chloroquine has been the mainstay of antimalarial treatment for the past 40 years, but resistance in P." | 2.38 | Clinical malaria in the tropics. ( Pukrittayakamee, S; White, NJ, 1993) |
| "Malaria is the most important emergency in people returning from tropical countries." | 2.38 | [Malaria: the most important emergency in subjects returning from the tropics]. ( Schubarth, P, 1993) |
| " Mefloquine prophylaxis has required a change in its dosing regimen." | 2.38 | Trends and controversies in the prophylaxis and treatment of malaria. ( Bia, FJ, 1992) |
| "Vivax malaria was generally a mild infection but falciparum malaria was often severe with 39% of patients experiencing complications including one death." | 2.38 | Malaria in Leicester 1983-1988: a review of 114 cases. ( Kent, J; Nicholson, KG; Wiselka, MJ, 1990) |
| "Malaria is not a disease of the past." | 2.36 | [Current information on treatment and prophylaxis of malaria (author's transl)]. ( Cambournac, FJ, 1979) |
| " Guidelines for cholorquine or quinine dosage in severe disease are proposed; each drug is given at a dose of 5 to 10 mg/kg in 10 ml/kg of fluid as an intravenous infusion in four hours at a frequency of dosing every 12 to 24 hours." | 2.36 | The treatment of severe falciparum malaria. ( Hall, AP, 1977) |
| "Cerebral malaria is an acute diffuse encephalopathy associated only with Plasmodium falciparum." | 2.35 | Cerebral Malaria. ( Bruce-Chwatt, LJ; Marsden, PD, 1975) |
| " knowlesi than chloroquine, as confirmed by both methods, with a mean estimated parasite clearance half-life of 2." | 1.91 | Quantification of parasite clearance in Plasmodium knowlesi infections. ( Anstey, NM; Barber, BE; Cooper, DJ; Dini, S; Grigg, MJ; Haghiri, A; Rajahram, GS; Rajasekhar, M; Sakam, SS; Simpson, JA; T Thurai Rathnam, J; William, T, 2023) |
| "Malaria is caused by parasite of the genus Plasmodium and is still one of the most important infectious diseases in the world." | 1.91 | Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. ( Aguiar, ACC; Andrade, AO; Araújo, JE; Araújo, MS; Bastos, AS; G Teles, CB; Gazzinelli, RT; Lima, AA; Martinez, LN; Medeiros, JF; Pereira, DB; Pontual, JDC; Santos, NAC; Silva, AMV; Vinetz, JM, 2023) |
| " Conversely, when the W2 systems were dosed with chloroquine, parasitemia levels were moderately decreased when compared to the 3D7 model." | 1.91 | Development of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation. ( Comiter, B; Hickman, JJ; Long, CJ; McAleer, CW; Rupar, MJ; Sasserath, T; Smith, E; Sriram, N, 2023) |
| "Malaria is a global health challenge with endemicity in sub-Saharan Africa, where there are multiple drug-resistant strains and limited access to modern health care facilities, especially in rural areas." | 1.91 | Anti-malarial and haematological evaluation of the ethanolic, ethyl acetate and aqueous fractions of Chromolaena odorata. ( Adeyemi, OS; Elebiyo, TC; Oluba, OM, 2023) |
| "Malaria is the fifth most lethal parasitic infections in the world." | 1.72 | Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity. ( Agnamey, P; Azas, N; Cohen, A; Damiani, C; Dassonville-Klimpt, A; Dormoi, J; Guillon, J; Marchivie, M; Mullié, C; Pradines, B; Schneider, J; Sonnet, P; Taudon, N; Tisnerat, C; Totet, A, 2022) |
| "Rutin was examined in this work for its anti-plasmodial activity against chloroquine-sensitive and resistant Plasmodium falciparum strains, as well as its anti-oxidative and anti-inflammatory activity against LPS-stimulated macrophage cells." | 1.72 | Rutin ameliorates malaria pathogenesis by modulating inflammatory mechanism: an in vitro and in vivo study. ( Bawankule, DU; Bhatt, D; Bisht, S; Kumar, A; Kumar, P; Kumar, S; Maurya, AK; Pal, A, 2022) |
| "Malaria is a major health problem in Peru despite substantial progress achieved by the ongoing malaria elimination program." | 1.72 | Drug resistance and population structure of Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon. ( Barazorda, K; Braga, G; Delgado-Ratto, C; Gamboa, D; Joya, CA; Lizewski, SE; Lucas, C; Nolasco, O; Ricopa, L; Salas, CJ; Sanchez, JF; Valdivia, HO; Villena, FE, 2022) |
| "Chloroquine was measured by high-performance liquid chromatography." | 1.62 | Exposure to chloroquine in male adults and children aged 9-11 years with malaria due to Plasmodium vivax. ( Ferreira Vieira, MVD; Vieira, JLF, 2021) |
| "Malaria is a global health problem with the greatest burden in sub-Saharan Africa (sSA)." | 1.62 | In-vivo anti-plasmodial activity of phosphate buffer extract of Calotropis procera latex in mice infected with Plasmodium berghei. ( Adejoh, J; Alli, LA; Egua, MO; Inyang, BA; Nwachukwu, KC; Okoh, MP, 2021) |
| "Malaria is a disease that requires new drugs not only to fight Plasmodium but also to reduce symptoms of infection such as fever and inflammation." | 1.56 | Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission. ( Bastos, MM; Boechat, N; Carvalho, RCC; Coutinho, JP; Ferreira, MLG; Krettli, AU; Pinheiro, LCS; Rosas, EC; Sa, PM; Seito, LN, 2020) |
| "Malaria is a serious disease and is one of the most alarming public health issues." | 1.51 | Efficacy of TLR7 agonistic imidazoquinoline as immunochemotherapeutic agent against P. Berghei ANKA infected rodent host. ( Bagai, U; Kaur, S; Kaushik, D; Salunke, DB; Saroa, R, 2019) |
| "Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal." | 1.51 | Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria. ( Azevedo-Quintanilha, IG; Bozza, PT; Campbell, RA; Castro-Faria-Neto, HC; Estato, V; Ferreira, AC; Nascimento, DO; Reis, PA; Silva, TI; Vieira-de-Abreu, A; Weyrich, AS; Zimmerman, GA, 2019) |
| " We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an optimal maternal/fetal dosing regimen to prevent ZIKV endocytosis in brain cells." | 1.51 | Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection. ( Badhan, RKS; Olafuyi, O, 2019) |
| "An alternative treatment for malaria caused by P." | 1.51 | [The treatment of malaria]. ( Bierhoff, M; Grobusch, MP; van Gool, T; van Hattem, JM; van Vugt, M; Visser, BJ, 2019) |
| " It was nongenotoxic in an Ames assay, an in vitro micronucleus assay, and an in vivo rat micronucleus assay when dosed orally up to 2000 mg/kg." | 1.46 | Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate. ( Berry, P; Campo, B; Cao, J; Ciaravino, V; Easom, EE; Erve, JCL; Freund, YR; Gamo, FJ; Guo, D; Jacobs, RT; Plattner, JJ; Rosenthal, PJ; Sanz, LM; Zhang, YK, 2017) |
| " The most promising compound (13) showed a reduction in parasitemia of 96% when dosed at 30 mg/kg orally once a day for 4 days in the P." | 1.43 | Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. ( Angulo-Barturen, I; Avery, VM; Baragaña, B; Campbell, SF; Duffy, S; Fairlamb, AH; Ferrer, S; Frearson, JA; Gamo, FJ; Gilbert, IH; Gray, DW; Grimaldi, R; Hallyburton, I; Jiménez-Díaz, B; Martínez, MS; Meister, S; Norcross, NR; Norval, S; Osuna-Cabello, M; Porzelle, A; Read, KD; Riley, J; Sanz, L; Simeons, FR; Stojanovski, L; Waterson, D; Willis, P; Wilson, C; Winzeler, EA; Wittlin, S, 2016) |
| "66) at the highest dosage administered (800 mg/kg) when compared with chloroquine diphosphate, the standard reference drug which had a % suppression of 90." | 1.43 | Antimalarial and cytotoxic properties of Chukrasia tabularis A. Juss and Turraea vogelii Hook F. Ex. Benth. ( Ajaiyeoba, EO; Fadare, AA; Fasinu, PS; Ogbole, OO; Saka, YA, 2016) |
| "The drug has been used successfully to treat malaria patients in clinical studies, thus validating IspC as an antimalarial target." | 1.42 | Prodrugs of reverse fosmidomycin analogues. ( Bacher, A; Behrendt, C; Brücher, K; Fischer, M; Gräwert, T; Held, J; Illarionov, B; Konzuch, S; Kurz, T; Lienau, C; Maes, L; Mordmüller, B; Wittlin, S, 2015) |
| " Furthermore, analogue 40 exhibited excellent in vivo antimalarial activity when dosed orally at 50 mg/kg once daily for 4 days in the Plasmodium berghei mouse model, which is superior to the activity seen with previously reported compounds, and with a slightly improved hERG profile." | 1.42 | Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines. ( Chibale, K; Douelle, F; Gonzàlez Cabrera, D; Han, Z; Lawrence, N; Le Manach, C; Njoroge, M; Paquet, T; Street, LJ; Taylor, D; Waterson, D; Wiesner, L; Wittlin, S; Witty, MJ, 2015) |
| "Malaria is one of the most devastating parasitic diseases worldwide." | 1.42 | Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin. ( Crespo-Lladó, KN; Ferrer-Rodríguez, I; Ortiz, JG; Pastrana-Mena, R; Serrano, AE; Vega-Rodríguez, J, 2015) |
| " In previous studies we reported on the ability of Pheroid vesicles to improve the bioavailability of poorly soluble drugs." | 1.42 | In vivo efficacy and bioavailability of lumefantrine: Evaluating the application of Pheroid technology. ( Denti, P; du Plessis, LH; Govender, K; Wiesner, L, 2015) |
| " The pharmacokinetic properties of active compounds were determined using a mouse model and blood samples were collected at different time intervals and analysed using LC-MS/MS." | 1.42 | Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model. ( Andayi, A; Chibale, K; Dambuza, NS; Egan, T; Evans, A; Norman, J; Smith, P; Taylor, D; Wiesner, L, 2015) |
| " Furthermore, 35 displayed high (78%) rat oral bioavailability with good oral exposure and plasma half-life." | 1.40 | Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1. ( Avery, VM; Charman, SA; Chibale, K; Douelle, F; Duffy, S; Gonzàlez Cabrera, D; Le Manach, C; March, C; Nchinda, AT; Ryan, E; Street, LJ; Taylor, D; Waterson, D; White, KL; Wiesner, L; Wittlin, S; Witty, MJ; Younis, Y, 2014) |
| "We report a case of dual infection of scrub typhus and malaria in a 48-year-old woman." | 1.40 | Scrub typhus and malaria co-infection causing severe sepsis. ( Kaushik, M; Mahajan, SK; Raina, R; Thakur, P, 2014) |
| " A 4-day dosage of 1,200 mg/kg of the extract showed, in the P." | 1.40 | Antimalarial efficacy, cytotoxicity, and genotoxicity of methanolic stem bark extract from Hintonia latiflora in a Plasmodium yoelii yoelii lethal murine malaria model. ( Beltrán, HI; Fortoul, TI; López, PY; Malagón, F; Reyes, AJ; Reynada, DY; Rivera, E; Rivera, N; Rojas, M, 2014) |
| " Pharmacokinetic studies indicated that low oral bioavailability due to poor ADME properties." | 1.39 | Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents. ( Gupta, S; Kancharla, P; Khaliq, T; Korthikunta, V; Kumar, V; Mohammad, IS; Puri, SK; Raju, KS; Sijwali, PS; Soni, A; Srivastava, K; Srivastava, RK; Tadigoppula, N, 2013) |
| "Numbers of drugs are available for the treatment of malaria but chloroquine diphosphate still remains a drug of choice." | 1.39 | Preparation and characterization of chloroquine loaded microspheres for prophylactic use. ( Ram, A; Sahu, SK, 2013) |
| "Plasmodium knowlesi malaria is an uncommon, but highly prevalent parasitic infection in parts of Malaysia." | 1.39 | Plasmodium knowlesi infection: a diagnostic challenge. ( Fan, L; Harkensee, C; Koay, E; Lee, SY, 2013) |
| "The chloroquine was treated by the actual drug content of effective nanochloroquine and the nanodrug was charged with its effective dose for fifteen days, after successive infection development in Swiss mice." | 1.39 | A novel chitosan based antimalarial drug delivery against Plasmodium berghei infection. ( Chattopadhyay, S; Das, S; Dash, SK; Mahapatra, SK; Majumder, S; Pramanik, P; Roy, S; Tripathy, S, 2013) |
| " These compounds exhibited marked advances over azithromycin in vitro in terms of potency against Plasmodium falciparum (over 100-fold) and high selectivity for the parasite and were characterized by moderate oral bioavailability in vivo." | 1.38 | Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin. ( Ager, A; Alihodžić, S; Bukvić Krajačić, M; Ellis, WY; Fajdetić, A; Hutinec, A; Ivezić-Schönfeld, Z; Jelić, D; Landek, G; Mesić, M; Milhous, WK; Ohrt, C; Padovan, J; Perić, M; Rupčić, R; Smith, KS; Spaventi, R; Ziher, D, 2012) |
| "Febrifugine is an alkaloid isolated from Dichroa febrifuga Lour as the active component against Plasmodium falciparum, but exhibits toxic side effects." | 1.38 | Febrifugine analogue compounds: synthesis and antimalarial evaluation. ( Chandrashekar, G; Chatterji, D; Meng, L; Robinson, K; Zhu, S, 2012) |
| " Even though oral bioavailability determined for compound 12 was low, novel quinoline C-3'-substituted 15-membered azalides represent an interesting subclass of antimalarial macrolides that need further research and evaluation." | 1.38 | Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents. ( Alihodžić, S; Ferrer, S; Herreros, E; Landek, G; Perić, M; Pešić, D; Spaventi, R; Starčević, K; Toplak, A, 2012) |
| " Pharmacokinetic studies in the rat indicated that this compound has good oral bioavailability (51% at 20 mg/kg) and a reasonable half-life (t(1/2) ∼ 7-8 h)." | 1.38 | 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential. ( Avery, V; Bashyam, S; Bhamidipati, R; Charman, SA; Chibale, K; Douelle, F; Duffy, S; Feng, TS; González Cabrera, D; Hardick, D; Joseph, JT; Katneni, K; Le Manach, C; Mannila, J; Morizzi, J; Nchinda, AT; Shackleford, DM; Waterson, D; White, KL; Wittlin, S; Witty, MJ; Younis, Y; Zabiulla, KM, 2012) |
| "Malaria is a severe infectious disease that causes between 655,000 and 1." | 1.38 | Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors. ( Cos, P; Dassonneville, S; Deprez, B; Deprez-Poulain, R; Flipo, M; Florent, I; Leroux, F; Maes, L; Piveteau, C, 2012) |
| "Parasitemia was 4% on day 8 when compared to that on day 0, whereas it was 9% on day 9." | 1.38 | Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis. ( Abolghasemi, E; Davoudi, M; Moosa-Kazemi, SH; Reisi, A; Satvat, MT, 2012) |
| "New drugs to treat malaria must act rapidly and be highly potent against asexual blood stages, well tolerated, and affordable to residents of regions of endemicity." | 1.38 | Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro. ( Kyle, DE; Mutka, T; Oduola, AM; Sáenz, FE; Udenze, K, 2012) |
| "Chloroquine [27." | 1.38 | Determinants of intermittent preventive treatment of malaria during pregnancy (IPTp) utilization in a rural town in Western Nigeria. ( Amoran, OE; Ariba, AA; Iyaniwura, CA, 2012) |
| "Malaria is one of the leading causes of severe infectious disease worldwide; yet, our ability to maintain effective therapy to combat the illness is continually challenged by the emergence of drug resistance." | 1.37 | Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. ( Bathurst, I; Buckner, FS; Burrows, J; Charman, SA; Charman, WN; Creason, S; Deng, X; El Mazouni, F; Floyd, DM; Gujjar, R; Matthews, D; Phillips, MA; Rathod, PK; Shackleford, DM; White, J; White, KL, 2011) |
| "Prodiginines are a family of linear and cyclic oligopyrrole red-pigmented compounds." | 1.37 | Antimalarial activity of natural and synthetic prodiginines. ( Alhamadsheh, M; Challis, GL; Haynes, SW; Kelly, JX; Papireddy, K; Reynolds, KA; Salem, SM; Smilkstein, M, 2011) |
| " Pharmacokinetic studies in rats revealed good oral bioavailability (51% at 22 mg/kg) with a moderate rate of absorption, reasonable half-life (t(1/2) 3 h), and high volume of distribution with moderately high plasma and blood clearance after IV administration." | 1.37 | Novel orally active antimalarial thiazoles. ( Burrows, JN; Charman, SA; Chibale, K; Douelle, F; Feng, TS; González Cabrera, D; Nchinda, AT; Ryan, E; Waterson, D; White, KL; Wittlin, S; Witty, MJ; Wu, Q; Younis, Y, 2011) |
| " The orally bioavailable lead imidazolopiperazine confers complete causal prophylactic protection (15 milligrams/kilogram) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity." | 1.37 | Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. ( Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y, 2011) |
| "Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax." | 1.37 | Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta). ( Cozens, S; Dow, GS; Gettayacamin, M; Hansukjariya, P; Imerbsin, R; Kenworthy, D; Komcharoen, S; Kyle, D; Milhous, W; Miller, A; Ohrt, C; Sattabongkot, J; Veazey, J, 2011) |
| "Intermittent preventive treatment (IPT) of malaria has recently been shown to be a highly effective way of reducing morbidity from malaria in children living in areas of seasonal malaria transmission, and it can be delivered efficiently by community volunteers." | 1.37 | Combining community case management and intermittent preventive treatment for malaria. ( Bojang, K; Greenwood, B; Pagnoni, F; Tagbor, H, 2011) |
| "Malaria is a major public health problem in Mali and diagnosis is typically based on microscopy." | 1.37 | Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali. ( Beavogui, AH; Diallo, M; Djimdé, A; Doumbo, OK; Doumbo, S; Kayentao, K; Niangaly, A; Ouattara, A; Saye, R; Thera, MA; Traoré, B, 2011) |
| " The optimized spiroindolone NITD609 shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model." | 1.36 | Spiroindolones, a potent compound class for the treatment of malaria. ( Beck, HP; Brun, R; Cohen, SB; Dartois, V; Dharia, NV; Diagana, TT; Fidock, DA; Goh, A; González-Páez, GE; Jegla, T; Keller, TH; Lakshminarayana, SB; Lee, MC; McNamara, C; Nosten, F; Plouffe, DM; Renia, L; Rottmann, M; Russell, B; Schmitt, EK; Seitz, P; Spencer, KR; Suwanarusk, R; Tan, J; Winzeler, EA; Yeung, BK; Zou, B, 2010) |
| "Malaria is a serious cause of mortality globally." | 1.36 | Antimalarial herbal remedies of Msambweni, Kenya. ( Gakuya, DW; Gathumbi, PK; Kiama, SG; Mbaria, JM; Nguta, JM, 2010) |
| "Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs are urgently required at an affordable price." | 1.35 | Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. ( Altarelli, M; Basilico, N; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Croft, S; Fattorusso, C; Fattorusso, E; Gemma, S; Kukreja, G; Nacci, V; Novellino, E; Parapini, S; Persico, M; Romano, MP; Ros, S; Savini, L; Taramelli, D; Yardley, V, 2008) |
| "Febrifugine is an alkaloid isolated from Dichroa febrifuga Lour as the active component against Plasmodium falciparum." | 1.35 | Synthesis and biological evaluation of febrifugine analogues as potential antimalarial agents. ( Gudise, C; Smith, E; Wei, L; Zeng, Y; Zhang, Q; Zhu, S, 2009) |
| "Acute respiratory distress syndrome is a well-known complication in Plasmodium falciparum infection." | 1.35 | Acute respiratory distress syndrome in a case of Plasmodium ovale malaria. ( Cuadros-González, J; Culebras-López, AM; de Pablo-Sánchez, R; Mesa-Latorre, JM; Rojo-Marcos, G, 2008) |
| "Pyrimethamine was significantly more commonly prescribed in private health facilities compared with public health facilities (p < 0." | 1.35 | Perception and practice of malaria prophylaxis in pregnancy among primary health care providers in Ibadan, Nigeria. ( Fawole, AO; Onyeaso, NC, 2008) |
| "Immunity to malaria has long been thought to be stage-specific." | 1.35 | Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage. ( Belnoue, E; Costa, FT; Depinay, N; Grüner, AC; Kayibanda, M; Mauduit, M; Mazier, D; Rénia, L; Rosa, DS; Sinnis, P; Snounou, G; Vigário, AM; Voza, T, 2008) |
| "Malaria was recognized as one of the diseases that cause fever in community by all the respondents." | 1.35 | Impact of health education on home treatment and prevention of malaria in Jengre, North Central Nigeria. ( Chirdan, OO; Ejembi, CL; Zoakah, AI, 2008) |
| "Iron supplementation is employed to treat post-malarial anaemia in environments where iron deficiency is common." | 1.35 | Iron incorporation and post-malaria anaemia. ( Abrams, SA; Austin, S; Cox, SE; Doherty, CP; Fulford, AJ; Hilmers, DC; Prentice, AM, 2008) |
| "Chloroquine was prescribed by 42." | 1.34 | Perception and practice of malaria prophylaxis in pregnancy among health care providers in Ibadan. ( Fawole, AO; Onyeaso, NC, 2007) |
| " Additionally, it was observed that 48% of females admitted a preference for injections over other dosage forms compared to 33." | 1.34 | The response of students to malaria and malaria therapy in a university in southwest Nigeria. ( Babalola, OO; Lamikanra, A, 2007) |
| "Imported malaria is a health problem and needs continuous monitoring as many clinicians are not aware of it." | 1.34 | Malaria in Egypt, Saudi Arabia and Yemen: a clinical pilot study. ( Ahmadi, M; El-Bahnasawy, M; Gouda, H; Ibrahim, A; Shahat, SA; Zaher, T, 2007) |
| " This study details a pharmacophore model that has been used to identify a potent, soluble, orally bioavailable antimalarial bisquinoline, metaquine (N,N'-bis(7-chloroquinolin-4-yl)benzene-1,3-diamine) (dihydrochloride), which is active against Plasmodium berghei in vivo (oral ID(50) of 25 micromol/kg) and multidrug-resistant Plasmodium falciparum K1 in vitro (0." | 1.33 | Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: design, construction, characterization, and pharmacology of metaquine. ( Alizadeh-Shekalgourabi, S; Auparakkitanon, S; Carr, P; Dascombe, MJ; Drew, MG; Dyas, AM; Evans, PG; Ismail, FM; Lloyd, M; Morris, H; Moule, WA; Wilairat, P, 2005) |
| "Malaria is a leading cause of death in Sub-Saharan Africa." | 1.33 | How sulfadoxine-pyrimethamine (SP) was perceived in some rural communities after phasing out chloroquine (CQ) as a first-line drug for uncomplicated malaria in Tanzania: lessons to learn towards moving from monotherapy to fixed combination therapy. ( Nsimba, SE, 2006) |
| "Congenital malaria is uncommon in France." | 1.33 | [Congenital malaria as a result of Plasmodium malariae in an infant born to a HIV-seropositive woman]. ( De Pontual, L; Gaudelus, J; Haouchine, D; Lachassine, E; Lebras, J; Ledeur, F; Poilane, I; Siriez, JY, 2005) |
| " Antimalarial drug dosage was incorrect in 84% of those who initiated self-treatment." | 1.33 | [Self-treatment of fever in the northern district of Dakar, Senegal]. ( Diedhiou, A; Juergens-Behr, A; Lemort, JP; Ndiaye, P; Tal-Dia, A, 2006) |
| "Malaria is a huge public health problem in Africa that is responsible for more than one million deaths annually." | 1.33 | A steep decline of malaria morbidity and mortality trends in Eritrea between 2000 and 2004: the effect of combination of control methods. ( Abdulmumini, U; Gebremeskel, T; Gebremichael, A; Ghebrat, Y; Gunawardena, D; Kosia, A; Mebrahtu, G; Mufunda, J; Nyarango, PM; Ogbamariam, A; Okbaldet, Y, 2006) |
| "Malaria is common in infants less than 6 months of age and associated with symptoms common with other childhood illnesses." | 1.33 | Epidemiology of malaria in infancy at Enugu, Nigeria. ( Oguonu, T; Okafor, HU, 2006) |
| "Malaria was presumed to be the diagnosis by 217 (40." | 1.33 | Pre-hospital treatment of febrile illness in children attending the General Outpatients Clinic, University College Hospital, Ibadan, Nigeria. ( Ajayi, IO; Falade, CO, 2006) |
| " The study findings showed that antimalarial property of goniothalamin was enhanced by combination with chloroquine at lower dose of each drug." | 1.33 | Antimalarial properties of Goniothalamin in combination with chloroquine against Plasmodium yoelii and Plasmodium berghei growth in mice. ( Khozirah, S; Mohd Ridzuan, MA; Noor Rain, A; Ruenruetai, U; Zakiah, I, 2006) |
| " The results indicate the suitability of this technique in antimalarial drug quality and bioavailability studies." | 1.33 | A simple technique for the detection of anti-malarial drug formulations and their presence in human urine. ( Akida, JA; Lemnge, MM; Lugimbana, L; Malebo, HM; Malle, LN; Segeja, MD, 2006) |
| "The first treatment of malaria in 2000 was monotherapy with quinine (P." | 1.32 | [Imported malaria in 2000 in 2 northern Paris hospitals]. ( Bouchaud, O; Durand, R; Godineau, N; Hamane, S; Keundjian, A; Le Bras, J; Ralaimazava, P, 2003) |
| " Less than 10% of cases of childhood 'malaria' had been treated with chloroquine at home, and 69% of those giving home medication did not know the correct dosage for a child." | 1.32 | Home treatment of 'malaria' in children in rural Gambia is uncommon. ( Bøgh, C; Clarke, SE; Lindsay, SW; Rowley, J; Walraven, GE, 2003) |
| " A two-day dosage of 20 mg base/kg of chloroquine alone showed little effect against P." | 1.32 | Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice. ( Ishih, A; Miyase, T; Suzuki, T; Terada, M; Watanabe, M, 2003) |
| "8%), absorption rate constant (37." | 1.32 | Interaction between chloroquine sulphate and aqueous extract of Azadirachta indica A. Juss (Meliaceae) in rabbits. ( Akah, PA; Nwafor, SV; Nworu, CS; Okoli, CO; Onyirioha, AC, 2003) |
| " The mean survival period of the mice treated with the extract in the established infection test was low, a possible indication of toxicity as a result of sub chronic administration of the extract." | 1.32 | Antimalarial activities of Tithonia diversifolia (Asteraceae) and Crossopteryx febrifuga (Rubiaceae) on mice in vivo. ( Agbedahunsi, JM; Elufioye, TO, 2004) |
| "To compare the pharmacokinetic differences of chloroquine in normal mice and the mice infected with the N and the RC strains of Plasmodium berghei." | 1.31 | [Studies on pharmacokinetics of chloroquine in mice infected with chloroquine-resistant strain of Plasmodium berghei]. ( Ni, YC; Shi, J; Song, GH; Wang, MJ, 2000) |
| "The search for short treatments for malaria is still a goal for many developing countries." | 1.31 | [Therapeutic efficacy of different antimalarial regimens in the Costa Rica-Nicaragua border region]. ( Bergonzoli, G; Rivers Cuadra, JC, 2000) |
| "Chloroquine treatment reduced the index of gametocytogenesis to 73% (5 mg/kg) and 55% (2." | 1.31 | The effects of subcurative doses of chloroquine on Plasmodium vinckei petteri gametocytes and on their infectivity to mosquitoes. ( Chabaud, AG; Coquelin, F; Gautret, P; Jacquemin, JL; Landau, I; Miltgen, F; Tailhardat, L; Voza, T, 2000) |
| "Malaria is a major cause of death among children in many parts of the world, even though simple and effective treatments exist." | 1.31 | Patterns of care for childhood malaria in Zambia. ( Baume, C; Helitzer, D; Kachur, SP, 2000) |
| "Chloroquine remained the treatment of choice for uncomplicated malaria infections until revised guidelines were launched in 1998 despite a plethora of scientific evidence on failure." | 1.31 | Using evidence to change antimalarial drug policy in Kenya. ( Omumbo, J; Rapuoda, B; Shretta, R; Snow, RW, 2000) |
| "Chloroquine was the most widely used antimalarial." | 1.31 | [Malaria and pregnancy: attitude of health care personnel during prenatal care in Cotonou, Benin]. ( Akogbeto, M; Nahum, A, 2000) |
| "Malaria is a major tropical disease, which kills two million people annually." | 1.31 | Aminonaphthoquinones--a novel class of compounds with potent antimalarial activity against Plasmodium falciparum. ( Azuine, MA; Balasubramanian, V; Kapadia, GJ; Sridhar, R, 2001) |
| "Chloroquine-treated and artemether-treated parasites displayed a pigment-clumping morphology and lowered the parasitaemia faster than dioncophylline B." | 1.31 | A comparison of the stage-specific efficacy of chloroquine, artemether and dioncophylline B against the rodent malaria parasite Plasmodium chabaudi chabaudi in vivo. ( Bringmann, G; Chimanuka, B; François, G; Heyden, YV; Holenz, J; Plaizier-Vercammen, J; Timperman, G, 2001) |
| "We conclude that malaria is the major cause of anemia in pregnancy in this region." | 1.30 | Seasonality, malaria, and impact of prophylaxis in a West African village I. Effect of anemia in pregnancy. ( Bouvier, P; Breslow, N; Delley, V; Dembele, HK; Doumbo, O; Kouriba, B; Mauris, A; Picquet, M; Robert, CF; Rougemont, A, 1997) |
| "Home treatment of malaria combining herbs and over-the-counter drugs and inadequate doses of chloroquine was widespread." | 1.30 | Malaria-related beliefs and behaviour in southern Ghana: implications for treatment, prevention and control. ( Afari, EA; Ahorlu, CK; Dunyo, SK; Koram, KA; Nkrumah, FK, 1997) |
| "Chloroquine plus Maloprim was used significantly more by general practitioners in older age groups, ie 45 years and over (p < 0." | 1.30 | Malaria prophylaxis prescribed for travellers from New Zealand. ( Heydon, JL; Leggat, PA; Menon, A, 1997) |
| "Spermidine was detected in about five-fold higher concentrations than putrescine and spermine which were detected in equimolar levels." | 1.30 | Polyamine metabolism in various tissues during pathogenesis of chloroquine-susceptible and resistant malaria. ( Chandra, S; Mishra, M; Pandey, VC; Tekwani, BL, 1997) |
| " All sanctioned providers limited their first choices of antimalarial drug to those recommended by the national malaria control program and reported using correct dosing regimens." | 1.30 | Use of antimalarial drugs in Mali: policy versus reality. ( Dicko, A; Diop, S; Djimde, A; Doumbo, O; Plowe, CV; Wellems, TE, 1998) |
| "Ascending parasitemias were stopped by chloroquine treatment when they were between 1." | 1.30 | Plasmodium chabaudi chabaudi: effect of low parasitemias on immunity in CB6F1 mice. ( Favila-Castillo, L; Garcia-Tapia, D; Monroy-Ostria, A, 1999) |
| "Chloroquine treatment of infected mice caused a decrease in parasitaemia which was associated with restoration of indices altered during infection towards normalization." | 1.30 | Studies on hepatic oxidative stress and antioxidant defence system during chloroquine/poly ICLC treatment of Plasmodium yoelii nigeriensis infected mice. ( Dutta, GP; Maheshwari, RK; Pandey, VC; Puri, SK; Siddiqi, NJ, 1999) |
| " While most patients with tertian malaria were cured with the standard chloroquine and primaquine regimen, a higher dosage was required for one case acquired in Papua New Guinea." | 1.30 | Imported malaria: successful treatment of 31 patients in the era of chloroquine resistance. ( Chang, HL; Chang, SC; Chen, YC; Fang, CT; Hsieh, WC; Hsueh, PR; Hung, CC, 1999) |
| "The prevalence of enlarged spleen was 57% in children and 10% in adults and closely matched the corresponding age-related parasite rate." | 1.29 | The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity. ( al-Yaman, F; Alpers, MP; Beck, HP; Genton, B; Gibson, N; Hii, J; Mellor, S; Narara, A; Smith, T, 1995) |
| "Treatment with chloroquine did not influence the intracellular level of GSH, but it was found to significantly decrease GR activity." | 1.29 | Plasmodium berghei: implication of intracellular glutathione and its related enzyme in chloroquine resistance in vivo. ( Dubois, VL; Pauly, G; Platel, DF; Tribouley-Duret, J, 1995) |
| "Chloroquine was the drug most widely used by prescribers and for self-treatment of malaria." | 1.29 | [Health personnel and population practices in the diagnosis of malaria and use of antimalarial drugs in Dakar]. ( Bah, IB; Diagne, AK; Diallo, S; Dieng, T; Dieng, Y; Faye, O; Gaye, O; Ndir, O, 1995) |
| " The concentration-time course was fitted to a multiple-dose pharmacokinetic model." | 1.29 | The pharmacokinetics of three multiple dose regimens of chloroquine: implications for malaria chemoprophylaxis. ( De Vries, PJ; Oosterhuis, B; Van Boxtel, CJ; Wetsteyn, JC, 1995) |
| "Despite the encouragement of early treatment, malaria was the major cause of death in children after the neonatal period in 1988." | 1.29 | Malaria treatment in Vanuatu: new national treatment guidelines. ( Reeve, PA, 1994) |
| " The chloroquine delivered in these liposomes intravenously at a dosage of 5 mg/kg of body weight per day on days 4 and 6 postinfection completely cured the animals (75 to 90%) of chloroquine-resistant P." | 1.29 | Chloroquine encapsulated in malaria-infected erythrocyte-specific antibody-bearing liposomes effectively controls chloroquine-resistant Plasmodium berghei infections in mice. ( Chandra, S; Choudhury, A; Gupta, CM; Owais, M; Varshney, GC, 1995) |
| "Chloroquine treatment alone does not prevent the death of the P." | 1.29 | The role of free radicals and antioxidative enzymes in erythrocytes and liver cells in the course of Plasmodium berghei and Plasmodium vinckei infection of mice. ( Földes, J; Matkovics, B; Matyi, A, 1994) |
| "There were 26 cases of cerebral malaria, with a death rate of 34." | 1.29 | [Malaria in children at the Sihanoukville Hospital (Cambodia)]. ( Imbert, P; Martin, YN; Migliani, R; Pheng, S; Sokhan, C; Yen, KK, 1994) |
| "Chloroquine treatment did not cause any significant alteration in the above-mentioned enzymes of normal mice." | 1.29 | Effect of Plasmodium berghei infection and antimalarial treatment on heme synthesis in mice. ( Pandey, VC; Puri, SK; Srivastava, P, 1994) |
| " To reduce the side effects, another test was carried out in 3 monkeys and the dosage regimen was modified to pyronaridine 6 mg/kg-artemether 10 mg/kg-chloroquine 20 mg/kg (PAC-2) once daily for 3 days." | 1.29 | [Studies on the establishment of malarial animal model of short-term relapse. III. Combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance]. ( Fang, Y; Lin, BY; Pan, YR; Zhang, JX; Zheng, H, 1993) |
| "Traveler's diarrhea is best prevented by avoiding high risk foods and beverages." | 1.29 | Counseling the international traveler. Update '93. ( Wilder, MH, 1993) |
| "Chloroquine treatment of non-parasitized and parasitized mice resulted in significant loss of the enzyme activity after about 6 weeks." | 1.29 | Effect of chloroquine on hepatic heme-oxygenase during Plasmodium berghei infection in mice. ( Dutta, GP; Pandey, VC; Puri, SK; Srivastava, P, 1993) |
| "Chloroquine resistance was induced in Plasmodium yoelii nigeriensis by the method of drug pressure." | 1.29 | Induction of chloroquine resistance in Plasmodium yoelii nigeriensis. ( Fagbenro-Beyioku, AF; Kimbi, HK, 1996) |
| "Thirteen cases of malaria are presented for their protean manifestations." | 1.29 | Protean manifestations of malaria--(multi organ dysfunction syndrome). ( Gaikwad, A; Jirwankar, PS; Talib, SH, 1996) |
| "Although self-treatment of malaria with oral and injectable drugs purchased at stores and pharmacies is very common, less than 10% of the respondents were aware of the correct curative dose of chloroquine." | 1.28 | Knowledge and beliefs about malaria on the Pacific coastal plain of Guatemala. ( Klein, RE; Ruebush, TK; Weller, SC, 1992) |
| " In 5 patients it was demonstrated that the amount of uptake of chloroquine into the hair varied proportionally with the dosage (from 500 mg/week to 10 g single dose) and with the time of administration." | 1.28 | Sequential concentration of chloroquine in human hair correlates with ingested dose and duration of therapy. ( Ochsendorf, FR; Raudonat, HW; Runne, U; Schmidt, K, 1992) |
| " In nine of 13 patients who received prophylaxis, there was inadequate dosing or poor compliance." | 1.28 | Imported malaria in the Bronx: review of 51 cases recorded from 1986 to 1991. ( Froude, JR; Tanowitz, HB; Weiss, LM; Wittner, M, 1992) |
| "Chloroquine treatment of malarious mice reduces by 80 percent the activity of this enzyme, without inhibiting release of FP from hemoglobin, and thereby causes excess nonpolymerized, nonhemozoin FP to accumulate." | 1.28 | Heme polymerase: modulation by chloroquine treatment of a rodent malaria. ( Chou, AC; Fitch, CD, 1992) |
| "Malaria is an important diagnosis that United States physicians must consider in the medical evaluation of returning travelers." | 1.28 | Malaria in travelers in Rhode Island: a review of 26 cases. ( Olds, GR; Opal, SM; Romulo, RL; Wiest, PM, 1991) |
| "Oral treatment with chloroquine (16 mg kg-1 body wt for 4 days) of P." | 1.28 | Effect of Plasmodium berghei infection and chloroquine on the hepatic drug metabolizing system of mice. ( Dutta, GP; Pandey, VC; Puri, SK; Srivastava, P; Tripathi, LM, 1991) |
| "Chloroquine resistance was detected in 1987 in Benin, and in the same year in Togo and Côte d'Ivoire." | 1.28 | [Current aspects of malarial chemoresistance of subjects autochthonous in the OCCGE countries (West Africa)]. ( Boureima, HS; Comlanvi, CE; Faye, O; Gayibor, A; Gbary, AR; Guiguemdé, TR; Lamizana, L; Maiga, AS; Niang, SD; Ouedraogo, JB, 1991) |
| "Cerebral malaria was noted in two falciparum cases with good response to treatment." | 1.28 | Medical treatment of malaria. ( Chen, ER; Hwang, KP, 1991) |
| "Malaria is the primary diagnostic consideration in any child recently returning from an endemic area who presents with fever." | 1.28 | Malaria in children. ( Newman, J; Pender, E, 1990) |
| "Case report of a severe form of neuropaludism, contracted in a territory with Plasmodium falciparum completely insensitive to chloroquine." | 1.28 | [Cerebral infarction in pernicious malaria. Diagnostic value of computed tomography]. ( Delvallée, G; Duval, G; Laporte, JP; Michel, G; Pham-Hung, G; Truffert, A, 1990) |
| "Chloroquine was most frequently used among antimalarial agents (in 123 cases, 65% of the total) for suppressing acute attacks." | 1.28 | [Clinical evaluation of antimalarial drugs]. ( Shimada, K; Tanabe, K, 1990) |
| "Chloroquine alone was successful in 83% of cases and chloroquine-spiramycin in 95% of cases (statistically significant)." | 1.28 | [Assessment of a chloroquine-spiramycin combination in the treatment of malaria in an area of moderate resistance]. ( Faurant, C; Kabeya, K; Kankolongo, L; Krim, G; Tshibemba, M, 1990) |
| "Homoharringtonine, 2." | 1.28 | Treatment of chloroquine-resistant malaria with esters of cephalotaxine: homoharringtonine. ( Brown, ND; Whaun, JM, 1990) |
| "Mass treatment with chloroquine, to which the parasites were fully sensitive, was followed by the same rate of re-infection in the parasite-positive and parasite-negative groups." | 1.28 | Malaria in Nigeria: a revisit. ( Ajayi, FO; Salako, LA; Sowunmi, A; Walker, O, 1990) |
| "Chloroquine poisoning has profound effects, chiefly on contractility and conduction of the heart." | 1.28 | [Chloroquine poisoning]. ( Aakhus, S; Aasarød, K, 1990) |
| "Desethylchloroquine and BDCQ were concentrated in the red cells of uninfected blood to the same extent as chloroquine." | 1.28 | Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. ( Ajayi, FO; Kuye, JO; Salako, LA, 1989) |
| " Based on children's weights and treatment histories provided by their mothers, the median total dosage of chloroquine given at home was 12." | 1.28 | Home treatment of febrile children with antimalarial drugs in Togo. ( Deming, MS; Gayibor, A; Jones, TS; Karsa, T; Murphy, K, 1989) |
| "Malaria is a persistent problem in the tribal dominated Koraput district of Orissa state." | 1.28 | Chloroquine sensitivity of P. falciparum in Koraput district, Orissa. ( Das, LK; Mohapatra, SS; Pani, SP, 1989) |
| "Treatment with chloroquine 1." | 1.28 | [Experimental studies on the incubation period and relapse patterns in vivax malaria in west Hunan]. ( He, YZ; Huang, Z; Li, QJ; Pang, LL; Tang, LY; Wang, WJ; Wang, ZM; Yang, BL; Zhang, XJ, 1989) |
| "falciparum malaria and unrousable coma)." | 1.28 | Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. ( Borgstein, A; Molyneux, ME; Taylor, TE; Wirima, JJ, 1989) |
| "Chloroquine (CQ) solution was separately mixed with the serum of mice infected with chloroquine-resistant 'NS' line (SMNS), the serum of mice infected with chloroquine-sensitive Plasmodium berghei ANKA strain (SMCS), and the serum of normal mice (SM)." | 1.28 | Antagonism of serum of mice infected with chloroquine-resistant 'NS' line to the antimalarial action of chloroquine. ( Chen, L; Li, GD; Qian, YL, 1989) |
| "Malaria is still the most important parasitic disease in the southeastern part of Iran." | 1.28 | Status of the response of Plasmodium falciparum to chloroquine and mefloquine in Iran. ( Edrissian, GH, 1989) |
| "Chloroquine tablets were distributed by health workers belonging to the community." | 1.28 | [The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission]. ( Baudon, D; Carnevale, P; Hervy, JP; Legros, F; Robert, V; Roux, J, 1989) |
| " A 25-mg base/kg dosage of amodiaquine produced parasite clearance in 34 of 38 (89%) children in a mean of 2." | 1.27 | Evaluation of amodiaquine treatment of chloroquine-resistant Plasmodium falciparum malaria on Zanzibar, 1982. ( Campbell, CC; Khatib, OJ; Payne, D; Schwartz, IK, 1983) |
| "The malaria was resistant to chloroquine at the RI level, the first such case reported from BMH Dharan." | 1.27 | Chloroquine resistant malignant subtertian malaria unmasked by systematic steroid therapy. ( Henderson, A; Livesey, JR, 1983) |
| " falciparum infections during the year died, and (v) increasing the dosage of chloroquine base from 15 to 25 to 37." | 1.27 | Absence of malaria mortality in villagers with chloroquine-resistant Plasmodium falciparum treated with chloroquine. ( Campbell, JR; Harun, S; Hoffman, SL; Hussein, PR; Marwoto, HA; Masbar, S; Smrkovski, L; Soewarta, A; Wiady, I, 1984) |
| " Reappraisal of quinine therapy has led to important modifications in dosage recommendations and recognition of a major complication of severe malaria associated with its use--hypoglycaemia." | 1.27 | Management of Plasmodium falciparum malaria. ( Phillips, RE, 1984) |
| " The present knowledge of CQ kinetics could provide a basis for revision of current dosage regimens in malaria suppression and rheumatoid disease to ensure efficacious and safe therapy." | 1.27 | The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects. ( Bergqvist, Y; Domeij-Nyberg, B; Frisk-Holmberg, M; Termond, E, 1984) |
| "Chloroquine retinopathy is a well-documented toxic manifestation of a commonly used systemic medication." | 1.27 | Progressive chloroquine retinopathy. ( Brucker, AJ; Campbell, C; Cobbs, W; Sassani, JW, 1983) |
| "Chloroquine does not inhibit proteolysis." | 1.27 | Comparative study of amino acid production in erythrocytes parasitized by Plasmodium sp. and Babesia hylomysci. ( Charet, P; Prensier, G; Slomianny, C, 1983) |
| "With the test in vivo and the bleeding dosage of chloroquine, authors report the rate of resistance of chloroquine to Plasmodium falciparum." | 1.27 | [Chemoresistance of Plasmodium falciparum in Kinshasha. In vivo tests and chloroquine absorption]. ( Elenga, E; Kaba, S; Kadima, N; Lokombe, B; Makengo, N; Mbanzulu, PN; Miankanina, B; Ngangoue, C; Ngbege, T; Ngimbi, NP, 1988) |
| " The blood concentration of chloroquine was dosed before, during and after treatment by a sensitive method." | 1.27 | [Low levels of chloroquine resistance of Plasmodium falciparum in the province of Zou in Benin]. ( Danis, M; Djivoh, C; Fayomi, EB; Gay, F; Massougbodji, A; Turk, P, 1988) |
| "Desipramine was found to be one of the most effective compounds yet described for the reversal of chloroquine resistance both in vitro and in vivo." | 1.27 | Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine. ( Bitonti, AJ; Davidson, DE; Kyle, DE; McCann, PP; Milhous, WK; Oduola, AM; Rossan, RN; Sjoerdsma, A, 1988) |
| "Chloroquine resistance was confirmed by testing in vitro and in vivo." | 1.27 | Multiple drug resistant Plasmodium falciparum malaria in a pregnant indigenous Zambian woman. ( Rolfe, M, 1988) |
| " The dosage of trans(E)-clopenthixol was optimized through a pharmacokinetic study, and the suppression of the growth of Plasmodium berghei in vivo was tested in mice, with chloroquine acting as the positive and saline as the negative control." | 1.27 | Effect of trans(E)-clopenthixol on Plasmodium berghei in vivo. ( Andersen, BJ; Jepsen, S; Kristiansen, JE; Kurtzhals, JA, 1988) |
| "The actual situation of the treatment of malaria for the past 10 years in Japan was investigated and analyzed." | 1.27 | Clinical evaluation of antimalarial regimens in Japan. ( Hioki, A; Ishizaki, T; Nakabayashi, T; Ohtomo, H; Tanabe, K, 1987) |
| "Malaria was holoendemic." | 1.27 | Community-based malaria control in Saradidi, Kenya: description of the programme and impact on parasitaemia rates and antimalarial antibodies. ( Collins, WE; Huong, AY; Kaseje, DC; Koech, DK; Roberts, JM; Shehata, MG; Spencer, HC; Stanfill, PS; Turner, A; Villinski, M, 1987) |
| "Quinine was therapeutically more effective in the intact mice than in the deprived mice early after initiation of treatment and, while the normal mice suffered a transient recrudescence after quinine, the deprived mice retained a high parasitaemia during and after treatment." | 1.27 | Reduced efficacy of chemotherapy of Plasmodium chabaudi in T cell-deprived mice. ( Doenhoff, MJ; Targett, GA, 1987) |
| "The clinical presentation and current treatment of malaria are reviewed." | 1.27 | Vivax malaria. ( Baker, PB; Dronen, SC, 1986) |
| " Four days of oral dosing with 500 mg/kg and 125 mg/kg of the methanol extract of A." | 1.27 | Screening Azadirachta indica and Pisum sativum for possible antimalarial activities. ( Abatan, MO; Makinde, MJ, 1986) |
| " The weekly dosage of the drug was adjusted according to age." | 1.27 | The implementation of community participation in the control of malaria in rural Tanjung Pinang, Indonesia. ( Muzaham, F; Pribadi, W; Rasidi, R; Rukmono, B; Santoso, T, 1986) |
| "Chloroquine treatment reversed the trend of inhibition in the animals that received the drug when parasitaemia was less than 30%." | 1.27 | Phagocytic function of monocytes of rhesus monkeys during Plasmodium knowlesi infection and the effect of treatment with chloroquine. ( Ganguly, NK; Mahajan, RC; Prasad, RN, 1986) |
| "Amodiaquine was associated with a 3." | 1.27 | Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis. ( Gyr, N; Schär, M; Stürchler, D, 1987) |
| " The shopkeeper frequently advised which drug to take and the dosage as well as selling the drugs." | 1.27 | Changes in sources of treatment occurring after inception of a community-based malaria control programme in Saradidi, Kenya. ( Kaseje, DC; Mburu, FM; Spencer, HC, 1987) |
| "Malaria is a potentially lethal disease." | 1.27 | Malaria in pregnancy. ( Moodley, J; Moodley, SC; Richards, A; Sankar, D, 1985) |
| "Chloroquine resistance was first detected in 1981 and this increased markedly in 1982." | 1.27 | Serial studies on the evolution of chloroquine resistance in an area of East Africa receiving intermittent malaria chemosuppression. ( Brubaker, G; Draper, CC; Geser, A; Kilimali, VA; Wernsdorfer, WH, 1985) |
| "Salinomycin was found to have a greater effect than lasalocid on asexual stages of this line." | 1.27 | The action of salinomycin-Na and lasalocid-Na on chloroquine- and mepacrine-resistant line of Plasmodium berghei K 173-strain in Wistar rats. ( Ganster, HJ; Mehlhorn, H; Raether, W; Seidenath, H, 1985) |
| " The higher dosage of chloroquine caused no exacerbations." | 1.26 | Effect of antimalarial drugs on psoriasis. ( Kuflik, EG, 1980) |
| "Chloroquine resistance was not demonstrated in vitro." | 1.26 | Sensitivity of Plasmodium falciparum isolates to chloroquine in Kisumu and Malindi, Kenya. ( Kiaraho, D; Masaba, SC; Spencer, HC, 1982) |
| "Malaria is an increasing hazard of tropical travel." | 1.26 | Imported malaria in adults in Auckland. ( Ellis-Pegler, RB; Palmer, CW, 1982) |
| "Chloroquine treatment (25 mg base/kg body-weight) giving serum concentrations of 0." | 1.26 | Serum concentrations of chloroquine in a patient with a late recrudescence of Kenyan Plasmodium falciparum malaria. ( Faehlmann, M; Hedman, P; Rombo, L, 1981) |
| "Chloroquine retinopathy is a drug disease that can be prevented." | 1.26 | [The therapy with synthetic antimalarial drugs controlled by fluorescence electroretinography (author's transl)]. ( Carpi, R; Cordella, M; Franchi, A; Neri, F, 1980) |
| " A sigmoidal dose-response curve is followed with 50% hemolysis being produced by 4 microM FP." | 1.26 | Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications. ( Chou, AC; Fitch, CD, 1980) |
| "Three patients with aplastic anaemia following chloroquine therapy are described." | 1.26 | Aplasia and leukaemia following chloroquine therapy. ( Chetiyawardana, AD; Nagaratnam, N; Rajiyah, S, 1978) |
| "In general tertian malaria is rarely fatal to adults, but in children the primary attack can be life threatening." | 1.26 | [Tertiary malaria with acute lung edema in a Turkish child]. ( Sauer, O, 1977) |
| "When sulfalene was administered during malaria, this difference was no longer apparent." | 1.26 | The influence of acetylator phenotype on the response to sulfalene in individuals with chloroquine-resistant falciparum malaria. ( Carson, PE; Frischer, H; Rieckmann, KH; Trenholme, GM; Williams, RL, 1978) |
| " The dosage was subsequently adjusted to keep the parasitemia below 5%." | 1.26 | Plasmodium berghei--infected mice. Focal glomerulonephritis in hyperimmune state. ( Bhamarapravati, N; Boonpucknavig, S; Boonpucknavig, V, 1979) |
| "Imported malaria has been increasing in the United States." | 1.26 | Malaria--a red alert. ( Amin, NM, 1979) |
| "No chloroquine resistance was therefore demonstrated, although 4-aminoquinoline prophylaxis had been given for almost 20 years to thousands of non-African non-immunes as well as in pregnant women and children in the town." | 1.26 | Habits of malaria chemoprophylaxis and an analysis of breakdowns in a West African mining town. ( Bengtsson, E; Brohult, J; Hedman, P; Rombo, L; Sirleaf, V, 1979) |
| "Four cases of malaria are described." | 1.26 | [Malaria: 4 case reports with "atypical" symptoms (author's transl)]. ( Haupt, I; Ringelmann, R; Röder-Quehl, M; Schmidt-Heydt, K; Stockinger, K, 1978) |
| "Of these illnesses, malaria is one of the most common and serious." | 1.26 | Symptoms and signs of malaria. ( Flegel, KM, 1976) |
| "In a patient with acute myelogenous leukemia infected with Plasmodium vivax, neither his underlying disease nor intensive cytotoxic chemotherapy appeared to ameliorate or worsen the clinical course of his infection." | 1.26 | Malaria complicating neoplastic disease. ( Armstrong, D; Tapper, ML, 1976) |
| "Chloroquine pressure was applied over a 22 month period on a somewhat isolated, malarious rubber estate by examination of residents at 4-week intervals and treatment of parasitaemias with chloroquine." | 1.25 | Increased frequency of chloroquine resistant P. falciparum on a rubber estate in Peninsular Malaysia during two years of systematic chloroquine treatment. ( Dondero, TJ; O'Holohan, DR; Parsons, RE, 1975) |
| "The treatment of chloroquine resistant malaria in West Malaysia is a subject of another paper but suffice it to say that increased doses of chloroquine have still been found to be effective in treating many cases of falciparum malaria from areas of chloroquine resistance." | 1.25 | Chloroquine resistant malaria in West Malaysia. ( Ali, AR; Fredericks, HJ; Ismail, O; Othman, AM; Ponnampalam, JT; Sandosham, AA; Seow, CL, 1975) |
| " In groups 1, 2, and 3 the dosages of chloroquine base administered alone were adjusted to body weight, surface area of subject, and age; in group 4 a combination of chloroquine diphosphate and pyrimethamine was given at a standard dosage related to age." | 1.25 | Effect of four different types of single-dose treatment with chloroquine and with chloroquine and pyrimethamine on Plasmodium falciparum infections in a semi-immune population in northern Nigeria. ( Kusnecov, R; Lietaert, P; Storey, J, 1972) |
| "Chloroquine-(14)C was used to study the processes which concentrate chloroquine in mouse red blood cells infected with chloroquine-sensitive or with chloroquine-resistant Plasmodium berghei." | 1.25 | Chloroquine resistance in malaria: a deficiency of chloroquine binding. ( Fitch, CD, 1969) |
| "In a man who had been in a coma for 24 hours with cerebral malaria dexamethasone had a dramatic, and probably life-saving, effect." | 1.25 | Use of dexamethasone in cerebral malaria. ( Dickinson, CJ; Woodruff, AW, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1651 (56.77) | 18.7374 |
| 1990's | 419 (14.41) | 18.2507 |
| 2000's | 379 (13.03) | 29.6817 |
| 2010's | 350 (12.04) | 24.3611 |
| 2020's | 109 (3.75) | 2.80 |
| Authors | Studies |
|---|---|
| Elslager, EF | 2 |
| Hutt, MP | 1 |
| Jacob, P | 1 |
| Johnson, J | 4 |
| Temporelli, B | 1 |
| Werbel, LM | 1 |
| Worth, DF | 1 |
| Rane, L | 1 |
| Genther, CS | 1 |
| Smith, CS | 1 |
| Vennerstrom, JL | 4 |
| Ellis, WY | 2 |
| Ager, AL | 6 |
| Andersen, SL | 3 |
| Gerena, L | 6 |
| Milhous, WK | 10 |
| Lin, AJ | 7 |
| Lee, M | 1 |
| Klayman, DL | 3 |
| Brossi, A | 1 |
| Venugopalan, B | 1 |
| Dominguez Gerpe, L | 1 |
| Yeh, HJ | 1 |
| Flippen-Anderson, JL | 1 |
| Buchs, P | 1 |
| Luo, XD | 1 |
| Milhous, W | 3 |
| Peters, W | 52 |
| Biot, C | 3 |
| Glorian, G | 1 |
| Maciejewski, LA | 2 |
| Brocard, JS | 2 |
| Figueiredo, JN | 1 |
| Räz, B | 1 |
| Séquin, U | 1 |
| Dorn, A | 3 |
| Ridley, RG | 3 |
| Raynes, KJ | 1 |
| Stocks, PA | 5 |
| O'Neill, PM | 10 |
| Park, BK | 6 |
| Ward, SA | 10 |
| Takaya, Y | 2 |
| Tasaka, H | 2 |
| Chiba, T | 1 |
| Uwai, K | 1 |
| Tanitsu, M | 1 |
| Kim, HS | 6 |
| Wataya, Y | 5 |
| Miura, M | 1 |
| Takeshita, M | 1 |
| Oshima, Y | 3 |
| Alzeer, J | 1 |
| Chollet, J | 3 |
| Heinze-Krauss, I | 1 |
| Hubschwerlen, C | 1 |
| Matile, H | 3 |
| Delarue, S | 3 |
| Girault, S | 2 |
| Maes, L | 11 |
| Debreu-Fontaine, MA | 3 |
| Labaeïd, M | 1 |
| Grellier, P | 6 |
| Sergheraert, C | 5 |
| Jensen, NP | 1 |
| Bliss, RA | 1 |
| Canfield, CJ | 5 |
| Kotecka, BM | 2 |
| Rieckmann, KH | 19 |
| Terpinski, J | 1 |
| Jacobus, DP | 1 |
| Davioud-Charvet, E | 2 |
| Schwöbel, B | 1 |
| Boehme, CC | 1 |
| Müssigbrodt, A | 1 |
| Schirmer, RH | 1 |
| Becker, K | 2 |
| Liu, M | 2 |
| Wilairat, P | 2 |
| Go, ML | 1 |
| Shuto, S | 1 |
| Minakawa, N | 1 |
| Niizuma, S | 1 |
| Matsuda, A | 1 |
| Hindley, S | 4 |
| Storr, RC | 2 |
| Searle, NL | 1 |
| Bray, PG | 4 |
| Davies, J | 2 |
| Kikuchi, H | 2 |
| Hirai, S | 2 |
| Iwabuchi, Y | 1 |
| Ooi, H | 1 |
| Hatakeyama, S | 1 |
| Zhu, S | 4 |
| Hudson, TH | 3 |
| Kyle, DE | 8 |
| Avery, MA | 1 |
| Alvim-Gaston, M | 1 |
| Vroman, JA | 1 |
| Wu, B | 1 |
| Ager, A | 3 |
| Robinson, BL | 15 |
| Charman, W | 1 |
| Jung, M | 1 |
| Lee, K | 1 |
| Kendrick, H | 2 |
| Croft, SL | 2 |
| Dua, VK | 4 |
| Sinha, SN | 1 |
| Biswas, S | 1 |
| Valecha, N | 6 |
| Puri, SK | 26 |
| Sharma, VP | 12 |
| Ryckebusch, A | 1 |
| Deprez-Poulain, R | 2 |
| Mouray, E | 2 |
| Murakami, N | 2 |
| Sugimoto, M | 2 |
| Kawanishi, M | 1 |
| Tamura, S | 1 |
| Begum, K | 1 |
| Kobayashi, M | 2 |
| Bachi, MD | 1 |
| Korshin, EE | 1 |
| Hoos, R | 1 |
| Szpilman, AM | 1 |
| Ploypradith, P | 1 |
| Xie, S | 1 |
| Shapiro, TA | 2 |
| Posner, GH | 1 |
| Singh, C | 5 |
| Gupta, N | 1 |
| Mukhtar, A | 2 |
| Randle, LE | 1 |
| Bickley, JF | 1 |
| O'Neil, IA | 1 |
| Maggs, JL | 3 |
| Hughes, RH | 1 |
| Winstanley, PA | 4 |
| Ghosh, S | 1 |
| Chan, JM | 1 |
| Lea, CR | 1 |
| Meints, GA | 1 |
| Lewis, JC | 1 |
| Tovian, ZS | 1 |
| Flessner, RM | 1 |
| Loftus, TC | 1 |
| Bruchhaus, I | 1 |
| Kemp, RG | 1 |
| Kobayashi, S | 2 |
| Nozaki, T | 1 |
| Oldfield, E | 1 |
| Malik, H | 2 |
| Jain, M | 1 |
| Vangapandu, S | 1 |
| Sachdeva, S | 1 |
| Singh, S | 5 |
| Singh, PP | 2 |
| Jena, GB | 1 |
| Tikoo, K | 1 |
| Ramarao, P | 1 |
| Kaul, CL | 1 |
| Jain, R | 2 |
| de Andrade-Neto, VF | 2 |
| Goulart, MO | 1 |
| da Silva Filho, JF | 1 |
| da Silva, MJ | 1 |
| Pinto, Mdo C | 1 |
| Pinto, AV | 1 |
| Zalis, MG | 3 |
| Carvalho, LH | 1 |
| Krettli, AU | 11 |
| Hamzé, A | 1 |
| Rubi, E | 1 |
| Arnal, P | 1 |
| Boisbrun, M | 1 |
| Carcel, C | 1 |
| Salom-Roig, X | 1 |
| Maynadier, M | 2 |
| Wein, S | 3 |
| Vial, H | 3 |
| Calas, M | 3 |
| Domínguez, JN | 4 |
| León, C | 3 |
| Rodrigues, J | 3 |
| Gamboa de Domínguez, N | 3 |
| Gut, J | 9 |
| Rosenthal, PJ | 14 |
| Nallan, L | 1 |
| Bauer, KD | 1 |
| Bendale, P | 1 |
| Rivas, K | 1 |
| Yokoyama, K | 1 |
| Hornéy, CP | 1 |
| Pendyala, PR | 1 |
| Floyd, D | 1 |
| Lombardo, LJ | 1 |
| Williams, DK | 1 |
| Hamilton, A | 1 |
| Sebti, S | 1 |
| Windsor, WT | 1 |
| Weber, PC | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Malaria Heart Disease Study: A Novel Pathway to Subclinical Heart Disease[NCT04445103] | 597 participants (Actual) | Observational | 2020-06-21 | Terminated (stopped due to Due to the COVID-19 pandemic it was not possible to complete the study inclusion as originally anticipated.) | |||
| A Randomized, Controlled Clinical Trial of Chloroquine as Chemoprophylaxis Versus Intermittent Preventive Therapy to Prevent Malaria in Pregnancy in Malawi[NCT01443130] | Phase 3 | 900 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Effectiveness of Community Level Deployment of Rapid Diagnostic Tests for Malaria in Afghanistan: Cluster Randomised Trial[NCT01403350] | Phase 4 | 2,421 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Artemether-lumefantrine vs Chloroquine in Patients With Acute Uncomplicated P. Knowlesi Malaria: a Randomized Open Label Trial in Sabah, Malaysia (CAN KNOW Trial)[NCT02001012] | Phase 3 | 123 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| Proflaxis for Healthcare Professionals Using Hydroxychloroquine Plus Vitamin Combining Vitamins C, D and Zinc During COVID-19 Pandemia: An Observational Study[NCT04326725] | 80 participants (Anticipated) | Observational | 2020-03-20 | Active, not recruiting | |||
| Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity[NCT05757167] | Phase 4 | 2,500 participants (Anticipated) | Interventional | 2023-11-06 | Recruiting | ||
| Incorporation of the 'Ottawa Malaria Decision Aid' Into the Pre-travel Consultation Process: Assessment of Travelers' Knowledge, Decisional Conflict, Preparation for Decision-making and Medication Adherence Compared to Standard Care[NCT01976325] | 100 participants (Anticipated) | Interventional | 2014-01-31 | Recruiting | |||
| Infections in Migrants in Sweden - the Importance of Malaria and Other Parasitic Infections[NCT05086887] | 715 participants (Anticipated) | Observational [Patient Registry] | 2019-04-15 | Recruiting | |||
| Clinical Efficacy of Artemisinin-based Combination Therapy for Treatment of Uncomplicated Plasmodium Falciparum Malaria in North Sumatera, Indonesia and the Association of Molecular Markers With Treatment Outcomes[NCT02325180] | Phase 4 | 338 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Phase 1, Open-Label Study to Evaluate Potential Pharmacokinetic Interaction of Orally Administered Primaquine and Chloroquine in Healthy Thai Adult Subjects[NCT01218932] | Phase 1 | 16 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Studies of P. Vivax and P. Falciparum Malaria in Cambodia[NCT00663546] | 1,978 participants (Actual) | Observational | 2008-03-24 | Completed | |||
| Artesunate-mefloquine vs Chloroquine in Patients With Acute Uncomplicated P. Knowlesi and P. Vivax Malaria: a Randomized Open Label Trial in Sabah, Malaysia[NCT01708876] | Phase 3 | 250 participants (Anticipated) | Interventional | 2012-10-31 | Completed | ||
| Development of Safer Drugs for Malaria in U.S. Troops, Civilian Personnel, and Travelers: Clinical Evaluation of Primaquine Enantiomer[NCT02898779] | Phase 1 | 36 participants (Actual) | Interventional | 2017-05-01 | Completed | ||
| Intermittent Preventive Treatment With Azithromycin-containing Regimens for the Prevention of Malarial Infections and Anaemia and the Control of Sexually Transmitted Infections in Pregnant Women in Papua New Guinea[NCT01136850] | Phase 3 | 2,793 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falciparum I[NCT03952650] | Phase 1/Phase 2 | 252 participants (Actual) | Interventional | 2019-05-23 | Completed | ||
| Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Dose Escalation Trial to Determine Safety and Development of Protective Efficacy After Exposure to Only Pre-erythrocytic Stages of Plasmodium Falciparum[NCT03083847] | Phase 1 | 55 participants (Actual) | Interventional | 2017-06-05 | Completed | ||
| Randomized, Open-label Controlled Trial of Daily Trimethoprim-sulfamethoxazole or Weekly Chloroquine Among Adults on Anti-retroviral Therapy in Malawi[NCT01650558] | 1,499 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| Intermittent Preventive Treatment During Pregnancy in Benin: a Randomized, Open, and Equivalent Trial Comparing Sulfadoxine-Pyrimethamine With Mefloquine[NCT00274235] | Phase 3 | 1,600 participants (Anticipated) | Interventional | 2005-07-31 | Completed | ||
| Efficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral Malaria: a Randomized Clinical Trial[NCT00124267] | Phase 3 | 108 participants | Interventional | 2003-09-30 | Active, not recruiting | ||
| Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Children With Sickle Cell Anaemia in Eastern and Southern Africa: a Double Blind Randomised Trial (CHEMCHA)[NCT04844099] | Phase 3 | 723 participants (Actual) | Interventional | 2021-04-09 | Completed | ||
| Safety, Tolerability and Pharmacokinetics of Tafenoquine After Weekly and Escalating Monthly Doses of Tafenoquine in Healthy Vietnamese Volunteers[NCT05203744] | Phase 4 | 200 participants (Anticipated) | Interventional | 2022-05-10 | Not yet recruiting | ||
| Hydroxychloroquine in Unexplained Recurrent Pregnancy Loss ,Double Blinded Randomized Controlled Trial .[NCT05237843] | Phase 1 | 70 participants (Anticipated) | Interventional | 2022-03-01 | Not yet recruiting | ||
| Comparison of the Effectiveness of Two Scheme Treatments to Treat Plasmodium Vivax Cases in Patients Living in Communities With Persistence of Transmission in Oaxaca and Chiapas, Mexico[NCT02394197] | Phase 4 | 153 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| New Tools for Diagnosis and Management of Febrile Illness in Travelers to the Tropics: a Cohort Study- JOKA I[NCT02900079] | 0 participants (Actual) | Observational [Patient Registry] | 2023-07-01 | Withdrawn (stopped due to delays in obtaining study materials) | |||
| A Longitudinal Study of Chloroquine as Monotherapy or in Combination With Artesunate, Azithromycin or Atovaquone-Proguanil to Treat Malaria in Children in Blantyre, Malawi[NCT00379821] | Phase 3 | 640 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Establishment of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers[NCT01083095] | Early Phase 1 | 18 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Phase 1 and Phase 2a Clinical Trial:Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites[NCT01082341] | Phase 1/Phase 2 | 27 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine (PQ) for the Treatment of Uncomplicated Plasmodium Vivax Infection[NCT02691910] | Phase 2/Phase 3 | 204 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Evaluation of Reproducibility of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers[NCT00367380] | Phase 2 | 18 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| Adapting Novel Molecular Diagnostic Methods for Detection of Plasmodium Knowlesi in Sarawak, Malaysia[NCT03988296] | 116 participants (Actual) | Observational | 2019-06-11 | Completed | |||
| [NCT00868465] | 600 participants (Anticipated) | Interventional | 2009-04-30 | Completed | |||
| Etude de l'Activite (Efficacite et Tolerance) de l'Association de la Chloroquine Avec la Dehydroepiandrosterone-Sulfate (Dheas) Dans le Traitement de l'Acces Palustre Simple A Plasmodium Falciparum[NCT00442403] | Phase 3 | 200 participants | Interventional | 2002-04-30 | Suspended (stopped due to At the end of the year 2002, Cameroon switched from chloroquine to amodiaquine as first-line therapy for of uncomplicated malaria.) | ||
| A Phase II, Double Blind, Randomized, Exploratory Study of Chloroquine for Reducing HIV-Associated Immune Activation[NCT00819390] | Phase 2 | 70 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Adults on Antibiotics[NCT00848003] | Phase 1 | 40 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| Prophylaxis With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19)[NCT04627467] | Phase 2 | 3,217 participants (Actual) | Interventional | 2020-03-28 | Completed | ||
| Pharmacokinetics of Chlorproguanil-Dapsone in Pregnant Women With Plasmodium Falciparum Infection, and Reinfection With P. Falciparum During Pregnancy Following Treatment[NCT00126971] | Phase 1 | 132 participants | Interventional | 2005-07-31 | Suspended | ||
| An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819] | 256 participants (Anticipated) | Observational | 2021-01-02 | Enrolling by invitation | |||
| A Randomized, Placebo-controlled Trial of Oral Doxycycline for the Prevention of Syphilis in HIV-positive Men Who Have Sex With Men (MSM)[NCT02864550] | Phase 4 | 52 participants (Actual) | Interventional | 2019-08-15 | Active, not recruiting | ||
| A Longitudinal Study Assessing the Infectious Status and Immunity of Mothers and Their Children in Lambaréné, Including Intermittent Treatment of Children With Sulfadoxine-pyrimethamine for Malaria Control and Its Impact on Long-term Health[NCT00167843] | Phase 4 | 1,189 participants | Interventional | 2002-12-31 | Completed | ||
| Comparison of Two Strategies for Control of Malaria Within A Primary Health Care Programme in the Gambia[NCT00294580] | Phase 4 | 2,253 participants | Interventional | 1982-04-30 | Completed | ||
| A Multi Center Randomized Open Label Trial on the Safety and Efficacy of Chloroquine for the Treatment of Hospitalized Adults With Laboratory Confirmed SARS-CoV-2 Infection in Vietnam[NCT04328493] | Phase 2 | 10 participants (Actual) | Interventional | 2020-04-07 | Completed | ||
| Assessment of Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa[NCT02974348] | Phase 3 | 300 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Safety and Protective Efficacy of a Synthetic Vaccine Derived From the CS Protein of Plasmodium Vivax: a Double-blind, Placebo-controlled, Randomized Clinical Trial in naïve and Pre-immune Colombian Volunteers[NCT04739917] | Phase 2 | 120 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Maternal participants were followed to outcome of the pregnancy. This outcome measure provides the number of placental malaria infections in maternal subjects diagnosed by the presence of parasites and/or pigment on histological section or molecular evidence of infection (PCR). (NCT01443130)
Timeframe: At delivery: Approximately 12-36 weeks after enrollment
| Intervention | percentage of participants (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 3.09 |
| Maternal Chloroquine IPT | 3.16 |
| Maternal SP IPT | 4.74 |
Maternal participants were followed to outcome of the pregnancy. Clinical malaria is defined as malaria infection at any parasite density with associated symptoms including at least one of the following: objective fever measured at the clinic, history of fever in the past 48 hours or other symptoms in the last 48 hours including: headache, myalgia, vomiting, or weakness. (NCT01443130)
Timeframe: Enrollment to delivery (approximately 12-36 weeks)
| Intervention | percentage of participants (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 0.67 |
| Maternal Chloroquine IPT | 1.33 |
| Maternal SP IPT | 3.00 |
Maternal participants were followed to outcome of the pregnancy. This outcome measure provides the number of positive for malaria cord blood smear and cord PCR results in maternal subjects based on the results of the thick smear and PCR from the cord blood sample. (NCT01443130)
Timeframe: At delivery: Approximately 12-36 weeks after enrollment
| Intervention | percentage of participants (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 1.95 |
| Maternal Chloroquine IPT | 2.78 |
| Maternal SP IPT | 0.80 |
Infants were followed from the time of delivery until 14 weeks of age. This outcome measure provides the incidence of infants with IUGR at delivery. IUGR is defined as weight below the 10th percentile for gestational age based on the World Health Organization (WHO) fetal growth curve. This classification is supported by literature resulting from the INTERGROWTH-21st Project; José Villar. (NCT01443130)
Timeframe: At delivery: Approximately 12-36 weeks after enrollment
| Intervention | percentage of participants (Number) |
|---|---|
| Infant Chloroquine Prophylaxis | 16.54 |
| Infant Chloroquine IPT | 18.01 |
| Infant SP IPT | 20.80 |
Maternal participants were followed to outcome of the pregnancy. The outcome measure provides the incidence of infants whose birthweight was less than 2500 grams. (NCT01443130)
Timeframe: At delivery: Approximately 12-36 weeks after enrollment
| Intervention | percentage of infants (Number) |
|---|---|
| Infant Chloroquine Prophylaxis | 15.59 |
| Infant Chloroquine IPT | 10.98 |
| Infant SP IPT | 12.11 |
Maternal participants were followed to outcome of the pregnancy. This outcome measure provides the number of malaria infection episodes measured by positive parasitemia in maternal subjects. (NCT01443130)
Timeframe: Enrollment to delivery (approximately 12-36 weeks)
| Intervention | percentage of participants (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 0.67 |
| Maternal Chloroquine IPT | 1.67 |
| Maternal SP IPT | 3.00 |
Maternal participants were followed to outcome of the pregnancy. The outcome measure provides the incidence of anemia among maternal participants during pregnancy . Anemia is defined as having a hemoglobin value less than 10 grams/deciliter (gm/dL). (NCT01443130)
Timeframe: From enrollment until delivery, approximately 12-36 weeks
| Intervention | percentage of maternal participants (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 18.3 |
| Maternal Chloroquine IPT | 23.7 |
| Maternal SP IPT | 22.0 |
Maternal participants were followed to outcome of the pregnancy. The outcome measure provides the incidence of severe anemia among maternal participants during pregnancy. Severe anemia is defined as having a hemoglobin value less than 7 gm/dl. (NCT01443130)
Timeframe: From enrollment until delivery, approximately 12-36 weeks
| Intervention | percentage of maternal participants (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 0.0 |
| Maternal Chloroquine IPT | 0.3 |
| Maternal SP IPT | 0.3 |
Maternal participants were followed to outcome of the pregnancy. The outcome measure provides the incidence of participants' deliveries whose outcome was miscarriage, defined as an infant delivered without any signs of life at less than 28 weeks of gestation. (NCT01443130)
Timeframe: At delivery: Approximately 12-36 weeks after enrollment
| Intervention | percentage of pregnancies (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 0.33 |
| Maternal Chloroquine IPT | 0.67 |
| Maternal SP IPT | 1.00 |
Maternal participants were followed to outcome of the pregnancy. The outcome measure provides the incidence of malaria infection in the placenta based on diagnosis by positive placental impression smear results. (NCT01443130)
Timeframe: At delivery: Approximately 12-36 weeks after enrollment
| Intervention | percentage of placentas (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 0 |
| Maternal Chloroquine IPT | 0 |
| Maternal SP IPT | 0.40 |
The placenta was collected at the time of delivery for examination by histology to determine malaria infection. Malaria infection was concluded if histology identified parasites or malaria pigment in the placental tissue. (NCT01443130)
Timeframe: At delivery: Approximately 12-36 weeks after enrollment
| Intervention | percentage of pregnancies (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 11.58 |
| Maternal Chloroquine IPT | 15.42 |
| Maternal SP IPT | 15.42 |
Maternal participants were followed to outcome of the pregnancy. The outcome measure provides the incidence of participants' deliveries whose outcome was preterm delivery, defined as delivery less than 37 weeks of gestation. The outcome of the delivery was not considered, and could have been live birth, stillbirth, or miscarriage. (NCT01443130)
Timeframe: At delivery: Approximately 12-36 weeks after enrollment
| Intervention | percentage of deliveries (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 8.46 |
| Maternal Chloroquine IPT | 9.89 |
| Maternal SP IPT | 6.84 |
Maternal participants were followed to outcome of the pregnancy. The outcome measure provides the incidence of participants' deliveries whose outcome was stillbirth, defined as an infant born without any signs of life at 28 weeks or greater of gestation. (NCT01443130)
Timeframe: At delivery: Approximately 12-36 weeks after enrollment
| Intervention | percentage of deliveries (Number) |
|---|---|
| Maternal Chloroquine Prophylaxis | 1.10 |
| Maternal Chloroquine IPT | 0.37 |
| Maternal SP IPT | 1.90 |
Infants were followed from the time of delivery until 14 weeks of age. This outcome measure provides the incidence of infants who died within 14 weeks of delivery. (NCT01443130)
Timeframe: For 14 weeks after delivery.
| Intervention | percentage of infants (Number) |
|---|---|
| Infant Chloroquine Prophylaxis | 2.22 |
| Infant Chloroquine IPT | 3.65 |
| Infant SP IPT | 3.09 |
Count of participants with local and systemic adverse events (AEs) and serious adverse events (SAEs) occurring after PfSPZ-CVac immunization. This outcome measure applies to main phase arms 1b, 2b, 4a, and 4b. Arms 5b and 6b were not performed as patent parasitemia with the higher dose of PfSPZ was not observed in the pilot phase (Arms 1a, 2a). (NCT03952650)
Timeframe: For the main phase: from the day of inoculation to approximately 6 months post-3rd inoculation. For the booster phase: from the time of inoculation to approximately 6 months post-booster inoculation
| Intervention | Participants (Count of Participants) |
|---|---|
| 1b - Safety/Efficacy: Dosing Interval on Days: 1, 29, 57 | 88 |
| 2b - Safety/Efficacy: Dosing Interval on Days: 1, 29, 57 | 59 |
| 4a - Safety Comparator: Dosing Interval on Days: 1, 29, 57 | 51 |
| 4b - Safety Comparator: Dosing Interval on Days: 1, 29, 57 | 36 |
Count of participants with local and systemic grade 3 signs or symptoms lasting more than 48 hours despite adequate management and serious adverse events (SAEs) occurring after PfSPZ-CVac DVI. Only arm 3a was analyzed for this outcome measure, per the protocol objectives. (NCT03952650)
Timeframe: From day of inoculation to 14 days post-inoculation
| Intervention | Participants (Count of Participants) |
|---|---|
| 3a - Pilot/Safety: Dosing Interval on Days: 1 | 0 |
Count of participants with positive sensitive blood smear (sBS) occurring after PfSPZ-CVac immunization starting on day 7 post DVI. Only pilot phase arms (Arms 1a, 2a) were analyzed for this outcome measure. Arms 5a and 6a were not performed, as no patent parasitemia was observed in either Arms 1a or 2a, per the protocol. (NCT03952650)
Timeframe: 7 -12 days post-inoculation
| Intervention | Participants (Count of Participants) |
|---|---|
| 1a - Pilot/Safety: Dosing Interval on Days: 1 | 0 |
| 2a - Pilot/Safety: Dosing Interval on Days: 1 | 0 |
Incidence of a clinical malaria diagnosis occurring after PfSPZ-Cvac challenge requiring treatment with atovaquone/proguanil (Malarone). (NCT03083847)
Timeframe: 12 days post PfSPZ Challenge injection
| Intervention | participants (Number) |
|---|---|
| Main (3): 3 Doses of 2x10^5 PfSPZ + Chloroquine + 7G8 CHMI | 0 |
| Pilot (5a): 1 Injection of 1x10^5 PfSPZ Challenge+Chloroquine | 0 |
| Pilot (5b): 1 Dose of 2x10^5 PfSPZ Challenge + Chloroquine | 0 |
Participants who had one or more episodes of related or/and unrelated adverse events (AEs). An AE is defined as any untoward medical occurrence temporarily associated with the subject's participation in research, whether or not considered related or not. Refer to adverse event table for specific AE. (NCT03083847)
Timeframe: 7 months
| Intervention | participants (Number) |
|---|---|
| Pilot (1a):1 Injection of 5x10^4 PfSPZ Challenge+Pyrimethamine | 2 |
| Pilot (1b):1 Injection of 1x10^5 PfSPZ Challenge+Pyrimethamine | 2 |
| Pilot (1d):1 Injection of 2x10^5 PfSPZ Challenge+Pyrimethamine | 3 |
| Main (2a):3 Doses of 2x10^5 PfSPZ Challenge+Pyrimethamine+NF54 | 8 |
| Main (2b):3 Doses of 2x10^5 PfSPZ Challenge+Pyrimethamine+7G8 | 9 |
| Main (3):3 Doses of 2x10^5 PfSPZ Challenge+Chloroquine+7G8 | 10 |
| Pilot (5a): 1 Injection of 1x10^5 PfSPZ Challenge+Chloroquine | 2 |
| Pilot (5b): 1 Injection of 2x10^5 PfSPZ Challenge+Chloroquine | 4 |
Participants with P. falciparum blood stage infection defined as detection of P. falciparum parasites by qPCR (real time NIH qPCR and sensitive retrospective Laboratory of Malaria Immunology & Vaccinology (LMIV) qPCR) following Sanaria® PfSPZ Challenge (NF54) via direct venous injection (DVI). (NCT03083847)
Timeframe: 14 days post PfSPZ Challenge injection
| Intervention | Participants (Number) |
|---|---|
| Pilot (1a):1 Injection of 5x10^4 PfSPZ Challenge+Pyrimethamine | 0 |
| Pilot (1b): 1 Dose of 1x10^5 PfSPZ Challenge + Pyrimethamine | 0 |
| Pilot (1d): 1 Dose of 2x10^5 PfSPZ Challenge + Pyrimethamine | 0 |
| Main (2a): 3 Doses of 2x10^5 PfSPZ + Pyrimethamine + NF54 CHMI | 0 |
| Main (2b): 3 Doses of 2x10^5 PfSPZ + Pyrimethamine + 7G8 CHMI | 0 |
Participants who had one or more episodes of serious adverse events (SAEs). SAE is defined as a life-threatening reaction or event that results in death. (NCT03083847)
Timeframe: 7 months
| Intervention | participants (Number) |
|---|---|
| Pilot (1a):1 Injection of 5x10^4 PfSPZ Challenge+Pyrimethamine | 0 |
| Pilot (1b):1 Injection of 1x10^5 PfSPZ Challenge+Pyrimethamine | 0 |
| Pilot (1d):1 Injection of 2x10^5 PfSPZ Challenge+Pyrimethamine | 0 |
| Main (2a):3 Doses of 2x10^5 PfSPZ Challenge+Pyrimethamine+NF54 | 0 |
| Main (2b):3 Doses of 2x10^5 PfSPZ Challenge+Pyrimethamine+7G8 | 0 |
| Main (3):3 Doses of 2x10^5 PfSPZ Challenge+Chloroquine+7G8 | 2 |
| Pilot (5a): 1 Injection of 1x10^5 PfSPZ Challenge+Chloroquine | 0 |
| Pilot (5b): 1 Injection of 2x10^5 PfSPZ Challenge+Chloroquine | 0 |
Occurrence of adverse events that are greater than or equal to Grade 3 that require discontinuation of TS or CQ prophylaxis (NCT01650558)
Timeframe: 32-66 months
| Intervention | Events per 100 participant-years (Number) |
|---|---|
| Standard of Care Trimethoprim Sulfamethoxazol (TS) Prophylaxis | 0 |
| Chloroquine (CQ) Prophylaxis | 0.24 |
| Discontinuation of Standard of Care (Control Arm) | 0 |
Incidence of bacterial infections and malaria (NCT01650558)
Timeframe: 32-66 months
| Intervention | Events per 100 participant-years (Number) |
|---|---|
| Standard of Care Trimethoprim Sulfamethoxazol (TS) Prophylaxis | 27.8 |
| Chloroquine (CQ) Prophylaxis | 37.4 |
| Discontinuation of Standard of Care (Control Arm) | 36.3 |
Number of Participants with at Least One CD4 Count <200 (NCT01650558)
Timeframe: Every 6 months for 22-66 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard of Care Trimethoprim Sulfamethoxazol (TS) Prophylaxis | 24 |
| Chloroquine (CQ) Prophylaxis | 23 |
| Discontinuation of Standard of Care (Control Arm) | 27 |
Number of participants who ever have a detectable viral load (>400 copies/ml). (NCT01650558)
Timeframe: Throughout study participation, measured every six months (2-5.5 years).
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard of Care Trimethoprim Sulfamethoxazol (TS) Prophylaxis | 24 |
| Chloroquine (CQ) Prophylaxis | 36 |
| Discontinuation of Standard of Care (Control Arm) | 33 |
Incidence of severe events (composite of death and WHO stage 3 and 4 illness) (NCT01650558)
Timeframe: 22-66 months
| Intervention | Events per 100 participant-years (Number) |
|---|---|
| Standard of Care Trimethoprim Sulfamethoxazol (TS) Prophylaxis | 3.3 |
| Chloroquine (CQ) Prophylaxis | 4.2 |
| Discontinuation of Standard of Care (Control Arm) | 4.2 |
Incidence of any WHO HIV stage 2, 3, or 4 illness (NCT01650558)
Timeframe: 32-66 months
| Intervention | Events per 100 participant-years (Number) |
|---|---|
| Standard of Care Trimethoprim Sulfamethoxazol (TS) Prophylaxis | 4.0 |
| Chloroquine (CQ) Prophylaxis | 5.7 |
| Discontinuation of Standard of Care (Control Arm) | 5.8 |
"A basic age-appropriate neurological examination was conducted on Day 28 of each malaria illness episode and also at Days 112 and 224, and at 1 year. Subjects were were counted as a change from 'normal' to 'abnormal' if they had the 'normal' (or not-applicable) response for the initial day 28 exam and an 'abnormal' response at their last exam. If a subject did not have an exam at 1 year then the last available exam that was not associated with an illness episode (either Day 112 or 224) was used." (NCT00379821)
Timeframe: 1 Year
| Intervention | Participants (Number) |
|---|---|
| Chloroquine Plus Artesunate | 6 |
| Chloroquine Plus Atovaquone-Proguanil | 4 |
| CQ Plus Azithromycin | 3 |
| CQ Monotherapy | 12 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 0 of first subsequent malaria episode (Episode 1)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 24.2 |
| Chloroquine Plus Atovaquone-Proguanil | 21.7 |
| CQ Plus Azithromycin | 22.4 |
| CQ Monotherapy | 25.3 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 0 of fourth subsequent malaria episode (Episode 4)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Atovaquone-Proguanil | 27.3 |
| CQ Plus Azithromycin | 24.9 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 0 of initial malaria episode (Episode 0)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 27.2 |
| Chloroquine Plus Atovaquone-Proguanil | 32.1 |
| CQ Plus Azithromycin | 27.5 |
| CQ Monotherapy | 26.2 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 0 of second subsequent malaria episode (Episode 2)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 26.1 |
| Chloroquine Plus Atovaquone-Proguanil | 23.0 |
| CQ Plus Azithromycin | 23.3 |
| CQ Monotherapy | 23.5 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 0 of third subsequent malaria episode (Episode 3)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 26.4 |
| Chloroquine Plus Atovaquone-Proguanil | 20.7 |
| CQ Plus Azithromycin | 18.6 |
| CQ Monotherapy | 16.2 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 14 of first subsequent malaria episode (Episode 1)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 14.5 |
| Chloroquine Plus Atovaquone-Proguanil | 14.2 |
| CQ Plus Azithromycin | 18.3 |
| CQ Monotherapy | 17.2 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 14 of fourth subsequent malaria episode (Episode 4)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Atovaquone-Proguanil | 13.9 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 14 of initial malaria episode (Episode 0)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 14.3 |
| Chloroquine Plus Atovaquone-Proguanil | 16.2 |
| CQ Plus Azithromycin | 17.8 |
| CQ Monotherapy | 15.5 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 14 of second subsequent malaria episode (Episode 2)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 116 |
| Chloroquine Plus Atovaquone-Proguanil | 14.7 |
| CQ Plus Azithromycin | 17.3 |
| CQ Monotherapy | 16.3 |
ALT values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. (NCT00379821)
Timeframe: Day 14 of third subsequent malaria episode (Episode 3)
| Intervention | International Units/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 17.8 |
| Chloroquine Plus Atovaquone-Proguanil | 13.6 |
| CQ Plus Azithromycin | 15.3 |
| CQ Monotherapy | 14.3 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 0 of first subsequent malaria episode (Episode 1)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 43.9 |
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
| CQ Plus Azithromycin | 43.7 |
| CQ Monotherapy | 43.6 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 0 of fourth subsequent malaria episode (Episode 4)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
| CQ Plus Azithromycin | 44.2 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 0 of initial malaria episode (Episode 0)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 44.2 |
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
| CQ Plus Azithromycin | 44.2 |
| CQ Monotherapy | 44.3 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 0 of second subsequent malaria episode (Episode 2)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 44.2 |
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
| CQ Plus Azithromycin | 44.2 |
| CQ Monotherapy | 46.4 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 0 of third subsequent malaria episode (Episode 3)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 44.2 |
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
| CQ Plus Azithromycin | 44.2 |
| CQ Monotherapy | 44.2 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 14 of first subsequent malaria episode (Episode 1)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 44.2 |
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
| CQ Plus Azithromycin | 44.2 |
| CQ Monotherapy | 44.2 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 14 of fourth subsequent malaria episode (Episode 4)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 14 of initial malaria episode (Episode 0)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 44.2 |
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
| CQ Plus Azithromycin | 44.2 |
| CQ Monotherapy | 44.2 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 14 of second subsequent malaria episode (Episode 2)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 44.2 |
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
| CQ Plus Azithromycin | 44.2 |
| CQ Monotherapy | 44.2 |
Creatine values were assessed from blood draws at Day 0 and Day 14 of each malaria episode. Samples that were below the limit of detection were reported as 44.2 micromoles/liter, equivalent to the lower limit of detection. (NCT00379821)
Timeframe: Day 14 of third subsequent malaria episode (Episode 3)
| Intervention | Micromole/Liter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 44.2 |
| Chloroquine Plus Atovaquone-Proguanil | 44.2 |
| CQ Plus Azithromycin | 44.2 |
| CQ Monotherapy | 44.2 |
Hemoglobin values were assessed from blood collected at the last study visit at one year after enrollment. Group means are stratified by participants 3 years of age and under, and over 3 to 5 years of age. (NCT00379821)
Timeframe: 1 year
| Intervention | Grams/Deciliter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 11.6 |
| Chloroquine Plus Atovaquone-Proguanil | 11.7 |
| CQ Plus Azithromycin | 12.2 |
| CQ Monotherapy | 11.8 |
Hemoglobin values were assessed from blood collected at the last study visit at one year after enrollment. Group means are stratified by participants 3 years of age and under, and over 3 to 5 years of age. (NCT00379821)
Timeframe: 1 year
| Intervention | Grams/Deciliter (Mean) |
|---|---|
| Chloroquine Plus Artesunate | 12.5 |
| Chloroquine Plus Atovaquone-Proguanil | 12.3 |
| CQ Plus Azithromycin | 12.1 |
| CQ Monotherapy | 12.5 |
The Global Positioning System (GPS) was used to establish the coordinates of participants' homes. The distribution of these coordinates was analyzed for evidence of clustering, or occurring closer together than would be expected on the basis of chance. Nearest Neighbor Index is a ratio of the observed mean distance over the expected mean distance. If the index is less than 1, the pattern exhibits clustering. If the index is greater than 1, the trend is toward dispersion. (NCT00379821)
Timeframe: 1 year
| Intervention | Index (Number) |
|---|---|
| All Groups | 0.328 |
A case of severe malaria included one or more of the following: Hemoglobin ≤5 g/dL; prostration; respiratory distress; bleeding; recent seizures, coma or obtundation (Blantyre coma score < 5); inability to drink, or persistent vomiting. All cases were then adjudicated by a panel of investigators prior to analysis. (NCT00379821)
Timeframe: 1 Year
| Intervention | Cases of severe malaria (Number) |
|---|---|
| Chloroquine Plus Artesunate | 0 |
| Chloroquine Plus Atovaquone-Proguanil | 2 |
| CQ Plus Azithromycin | 2 |
| CQ Monotherapy | 6 |
Clinical malaria episode was defined as at least one symptom of malaria and a positive malaria smear. The number of clinical malaria episodes (not including the initial malaria episode) reported by participants during follow up is presented as the number per Person Years at Risk (PYAR). (NCT00379821)
Timeframe: 1 year
| Intervention | Episodes per PYAR (Number) |
|---|---|
| Chloroquine Plus Artesunate | 0.61 |
| Chloroquine Plus Atovaquone-Proguanil | 0.68 |
| CQ Plus Azithromycin | 0.64 |
| CQ Monotherapy | 0.59 |
Participants were enrolled in the study at the time of the initial episode of malaria. If the participant presented with a subsequent episode of malaria at any time during the one year of follow-up, the presence of parasites with the mutation pfCRT 76T was measured with filter paper specimens collected at the time of enrollment and with successful parasite DNA amplification using pyrosequencing. (NCT00379821)
Timeframe: Recrudescent episodes of malaria within one year of enrollment
| Intervention | participants (Number) |
|---|---|
| Chloroquine Plus Artesunate | 0 |
| Chloroquine Plus Atovaquone-Proguanil | 0 |
| CQ Plus Azithromycin | 1 |
| CQ Monotherapy | 0 |
The presence of parasites with the mutation pfCRT 76T was measured with filter paper specimens collected at the time of enrollment and with successful parasite DNA amplification using pyrosequencing. (NCT00379821)
Timeframe: Day 0 of initial episode of malaria
| Intervention | participants (Number) |
|---|---|
| Chloroquine Plus Artesunate | 1 |
| Chloroquine Plus Atovaquone-Proguanil | 0 |
| CQ Plus Azithromycin | 0 |
| CQ Monotherapy | 0 |
Adequate clinical and parasitologic response (ACPR) was defined as the absence of parasitemia at Day 28 and without previously meeting any of the criteria of early treatment or late clinical failure. (NCT00379821)
Timeframe: Day 28 of first subsequent malaria episode (Episode 1)
| Intervention | Participants (Number) |
|---|---|
| Chloroquine Plus Artesunate | 46 |
| Chloroquine Plus Atovaquone-Proguanil | 42 |
| CQ Plus Azithromycin | 37 |
| CQ Monotherapy | 39 |
Adequate clinical and parasitologic response (ACPR) was defined as the absence of parasitemia at Day 28 and without previously meeting any of the criteria of early treatment or late clinical failure. (NCT00379821)
Timeframe: Day 28 of fourth subsequent malaria episode (Episode 4)
| Intervention | Participants (Number) |
|---|---|
| Chloroquine Plus Atovaquone-Proguanil | 2 |
| CQ Plus Azithromycin | 1 |
Adequate clinical and parasitologic response (ACPR) was defined as the absence of parasitemia at Day 28 and without previously meeting any of the criteria of early treatment or late clinical failure. (NCT00379821)
Timeframe: Day 28 of initial malaria episode (Episode 0)
| Intervention | Participants (Number) |
|---|---|
| Chloroquine Plus Artesunate | 143 |
| Chloroquine Plus Atovaquone-Proguanil | 133 |
| CQ Plus Azithromycin | 137 |
| CQ Monotherapy | 135 |
Adequate clinical and parasitologic response (ACPR) was defined as the absence of parasitemia at Day 28 and without previously meeting any of the criteria of early treatment or late clinical failure. (NCT00379821)
Timeframe: Day 28 of second subsequent malaria episode (Episode 2)
| Intervention | Participants (Number) |
|---|---|
| Chloroquine Plus Artesunate | 17 |
| Chloroquine Plus Atovaquone-Proguanil | 14 |
| CQ Plus Azithromycin | 12 |
| CQ Monotherapy | 6 |
Adequate clinical and parasitologic response (ACPR) was defined as the absence of parasitemia at Day 28 and without previously meeting any of the criteria of early treatment or late clinical failure. (NCT00379821)
Timeframe: Day 28 of third subsequent malaria episode (Episode 3)
| Intervention | Participants (Number) |
|---|---|
| Chloroquine Plus Artesunate | 4 |
| Chloroquine Plus Atovaquone-Proguanil | 4 |
| CQ Plus Azithromycin | 6 |
| CQ Monotherapy | 0 |
1727 non-zero concentration measurements from 479 participants were pooled and used for population pharmacokinetic modeling in Monolix413s. Compartmental population pharmacokinetic modeling was used due to highly sparse data. The model was parameterized in terms of absorption rate constant for chloroquine (Ka), apparent clearance for chloroquine (CL/F, with F as the unknown oral bioavailability), apparent volume of distribution of the central and peripheral compartments for chloroquine (Vd/F), and the inter-compartmental clearance for chloroquine (Q/F). Only these primary population pharmacokinetic parameters could be estimated using the type of data collected. The best-fit population PK model was then used to estimate individual parameter estimates to derive Cmax in nanograms per milliliter (ng/mL). (NCT00379821)
Timeframe: Day 0 - Day 28
| Intervention | ng/mL chloroquine (Median) |
|---|---|
| Chloroquine Plus Artesunate | 351.0 |
| Chloroquine Plus Atovaquone-Proguanil | 345.1 |
| CQ Plus Azithromycin | 353.1 |
| CQ Monotherapy | 384.2 |
Participants were enrolled at the time of initial malaria episode and treated. Subsequent to treatment, participants who subsequently suffered new malaria episodes were monitored for the additional occurrence of new and recrudescent malaria infections, which were distinguished by analysis of the infecting parasites using merozoite surface protein-2 polymorphic gene length variation. (NCT00379821)
Timeframe: Day 28 to 1 year
| Intervention | participants (Number) | |
|---|---|---|
| New infections | Recrudescent infections | |
| Chloroquine Plus Artesunate | 0 | 0 |
| Chloroquine Plus Atovaquone-Proguanil | 0 | 0 |
| CQ Monotherapy | 1 | 1 |
| CQ Plus Azithromycin | 1 | 2 |
Participants were enrolled at the time of initial malaria episode and treated. Subsequent to treatment, subjects were monitored for the occurrence of new and recrudescent malaria infections, which were distinguished by analysis of the infecting parasites using merozoite surface protein-2 polymorphic gene length variation. (NCT00379821)
Timeframe: 28 days to 1 year
| Intervention | participants (Number) | |
|---|---|---|
| New infections | Recrudescent infections | |
| Chloroquine Plus Artesunate | 0 | 1 |
| Chloroquine Plus Atovaquone-Proguanil | 0 | 0 |
| CQ Monotherapy | 0 | 0 |
| CQ Plus Azithromycin | 1 | 0 |
1727 non-zero concentration measurements from 479 participants were pooled and used for population pharmacokinetic modeling in Monolix413s. Compartmental population pharmacokinetic modeling was used due to highly sparse data. The model was parameterized in terms of absorption rate constant for chloroquine (Ka), apparent clearance for chloroquine (CL/F, with F as the unknown oral bioavailability), apparent volume of distribution of the central and peripheral compartments for chloroquine (Vd/F), and the inter-compartmental clearance for chloroquine (Q/F). Only these primary population pharmacokinetic parameters could be estimated using the type of data collected. The best-fit population PK model was then used to estimate individual parameter estimates to derive Tmax and half-life. (NCT00379821)
Timeframe: Day 0 - Day 28
| Intervention | Hours (Median) | |
|---|---|---|
| Time of maximal concentration (Tmax) | Chloroquine half-life | |
| Chloroquine Plus Artesunate | 5.6 | 41.6 |
| Chloroquine Plus Atovaquone-Proguanil | 5.6 | 46.2 |
| CQ Monotherapy | 5.6 | 44.5 |
| CQ Plus Azithromycin | 5.5 | 41.3 |
The cumulative hazard of having a malaria attack within one year for those participants who travelled and slept in rural areas (outside the city) versus those who did not was calculated and is presented as a life table to display the number of subjects at risk, the number with first clinical episode and the number censored at each time point. Participants are right-censored at the time of first malaria episode. Participants who did not develop malaria during follow-up or were lost to follow-up were censored at the time of their last visit. (NCT00379821)
Timeframe: Days 0 - 420
| Intervention | participants (Number) | ||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Days 0-27 - Number At Risk | Days 0-27 - Number with Malaria | Days 0-27 - Number Censored | Days 28-55 - Number At Risk | Days 28-55 - Number with Malaria | Days 28-55 - Number Censored | Days 56-83 - Number At Risk | Days 56-83 - Number with Malaria | Days 56-83 - Number Censored | Days 84-111 - Number At Risk | Days 84-111 - Number with Malaria | Days 84-111 - Number Censored | Days 112-139 - Number At Risk | Days 112-139 - Number with Malaria | Days 112-139 - Number Censored | Days 140-167 - Number At Risk | Days 140-167 - Number with Malaria | Days 140-167 - Number Censored | Days 168-195 - Number At Risk | Days 168-195 - Number with Malaria | Days 168-195 - Number Censored | Days 196-223 - Number At Risk | Days 196-223 - Number with Malaria | Days 196-223 - Number Censored | Days 224-251 - Number At Risk | Days 224-251 - Number with Malaria | Days 224-251 - Number Censored | Days 252-279 - Number At Risk | Days 252-279 - Number with Malaria | Days 252-279 - Number Censored | Days 280-307 - Number At Risk | Days 280-307 - Number with Malaria | Days 280-307 - Number Censored | Days 308-335 - Number At Risk | Days 308-335 - Number with Malaria | Days 308-335 - Number Censored | Days 336-363 - Number At Risk | Days 336-363 - Number with Malaria | Days 336-363 - Number Censored | Days 364-391 - Number At Risk | Days 364-391 - Number with Malaria | Days 364-391 - Number Censored | Days 392 - 420 - Number At Risk | Days 392 - 420 - Number with Malaria | Days 392 - 420 - Number Censored | |
| Participants Who Did Not Travel and Sleep Outside the City | 201 | 0 | 28 | 173 | 4 | 10 | 159 | 9 | 16 | 134 | 12 | 10 | 112 | 4 | 5 | 103 | 2 | 7 | 94 | 1 | 3 | 90 | 4 | 9 | 77 | 1 | 6 | 70 | 1 | 5 | 64 | 4 | 3 | 57 | 5 | 2 | 50 | 3 | 7 | 40 | 0 | 38 | 2 | 0 | 2 |
| Participants Who Traveled and Slept Outside the City | 432 | 0 | 63 | 369 | 13 | 26 | 330 | 11 | 21 | 298 | 12 | 16 | 270 | 13 | 17 | 240 | 3 | 22 | 215 | 3 | 16 | 196 | 4 | 16 | 176 | 12 | 4 | 160 | 12 | 8 | 140 | 7 | 4 | 129 | 8 | 8 | 113 | 8 | 2 | 103 | 2 | 100 | 1 | 0 | 1 |
Thick blood smear was performed to patients daily on days 7 to 23, and every other day until day 29. Any prove of P. vivax infection was considered positive and confirmed later by real time polymerase chain reaction (rPCR). (NCT00367380)
Timeframe: Twenty eight days
| Intervention | days (Mean) |
|---|---|
| Group 1 | 11 |
| Group 2 | 11 |
| Group 3 | 9 |
The baseline percent CD8 HLA-DR+/CD38+ (mean of pre-entry and entry percent CD8 HLA-DR+/CD38+) was subtracted from the mean of week 10 and week 12 percent CD8 HLA-DR+/CD38+. (NCT00819390)
Timeframe: At pre-entry, entry, weeks 10 and 12
| Intervention | percent of CD8 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | -2.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | -0.5 |
| C: Chloroquine Then Placebo for On-ART Participants | -3.1 |
| D: Placebo Then Chloroquine for On-ART Participants | -1.2 |
The baseline percent CD8 HLA-DR+/CD38+ (mean of pre-entry and entry percent CD8 HLA-DR+/CD38+) was subtracted from the mean of week 22 and week 24 percent CD8 HLA-DR+/CD38+. (NCT00819390)
Timeframe: At Pre-entry, entry, Weeks 22 and 24
| Intervention | percent of CD8 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 10.8 |
| C: Chloroquine Then Placebo for On-ART Participants | -2.4 |
For Arm A: Chloroquine then Placebo for off-ART participants and Arm C: Chloroquine then Placebo for on-ART participants, the baseline percent CD8 HLA-DR+/CD38+ (mean of pre-entry and entry percent CD8 HLA-DR+/CD38+) was subtracted from the mean of week 10 and week 12 percent CD8 HLA-DR+/CD38+. For Arm B: Placebo then Chloroquine for off-ART participants and Arm D: Placebo then Chloroquine for on-ART participants, the mean of week 10 and week 12 percent CD8 HLA-DR+/CD38+ was subtracted from the mean of week 22 and week 24 percent CD8 HLA-DR+/CD38+. (NCT00819390)
Timeframe: For Arms A and C: Pre-entry, entry, weeks 10 and 12. For Arms B and D: Weeks 10, 12, 22 and 24
| Intervention | percent of CD8 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | -2.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.5 |
| C: Chloroquine Then Placebo for On-ART Participants | -3.1 |
| D: Placebo Then Chloroquine for On-ART Participants | -2.9 |
The mean of week 10 and week 12 percent CD8 HLA-DR+/CD38+ is subtracted from the mean of the week 22 and week 24 percent CD8 HLA-DR+/CD38+ (NCT00819390)
Timeframe: At Weeks 10, 12, 22 and 24
| Intervention | percent of CD8 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 5.5 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.5 |
| C: Chloroquine Then Placebo for On-ART Participants | -0.1 |
| D: Placebo Then Chloroquine for On-ART Participants | -2.9 |
Baseline CD4 count (mean of pre-entry and entry CD4 count) is subtracted from the mean of week 10 and week 12 CD4 count (NCT00819390)
Timeframe: At pre-entry, entry, weeks 10 and 12
| Intervention | cells/mm^3 (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | -27 |
| B: Placebo Then Chloroquine for Off-ART Participants | -11 |
| C: Chloroquine Then Placebo for On-ART Participants | -6 |
| D: Placebo Then Chloroquine for On-ART Participants | 7 |
Results reported are for entry fasting LPS. (NCT00819390)
Timeframe: At entry
| Intervention | pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 13.68 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.64 |
| C: Chloroquine Then Placebo for On-ART Participants | 8.00 |
| D: Placebo Then Chloroquine for On-ART Participants | 7.00 |
Results reported are the week 12 fasting LPS. (NCT00819390)
Timeframe: At week 12
| Intervention | pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 14.37 |
| B: Placebo Then Chloroquine for Off-ART Participants | 13.06 |
| C: Chloroquine Then Placebo for On-ART Participants | 7.00 |
| D: Placebo Then Chloroquine for On-ART Participants | 7.00 |
Results reported are the week 24 fasting LPS. (NCT00819390)
Timeframe: At week 24
| Intervention | pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 20.54 |
| B: Placebo Then Chloroquine for Off-ART Participants | 2.83 |
| C: Chloroquine Then Placebo for On-ART Participants | 7.00 |
| D: Placebo Then Chloroquine for On-ART Participants | 8.00 |
Results reported are for HIV-1 RNA (copies/mL) at study entry for off-ART participants. (NCT00819390)
Timeframe: At Entry
| Intervention | log10 copies/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 4.48 |
| B: Placebo Then Chloroquine for Off-ART Participants | 4.42 |
Events included signs and symptoms, laboratory abnormalities and/or clinical events grade 3 or higher which were described by site clinician blinded to the treatment arm as definitely or possibly related to the study treatment. (NCT00819390)
Timeframe: From start of study treatment to study completion at week 28
| Intervention | participants (Number) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1 |
| C: Chloroquine Then Placebo for On-ART Participants | 1 |
| D: Placebo Then Chloroquine for On-ART Participants | 0 |
Baseline CD4 HLA-DR+/CD38+ is computed as the mean of pre-entry and entry CD4 HLA-DR+/CD38+. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | percent of CD4 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 8.5 |
| B: Placebo Then Chloroquine for Off-ART Participants | 9.8 |
| C: Chloroquine Then Placebo for On-ART Participants | 8.7 |
| D: Placebo Then Chloroquine for On-ART Participants | 9.9 |
Results reported are the week 12 percentage of CD4 expressing HLA-DR+/CD38+. (NCT00819390)
Timeframe: At Week 12
| Intervention | percent of CD4 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 6.5 |
| B: Placebo Then Chloroquine for Off-ART Participants | 10.5 |
| C: Chloroquine Then Placebo for On-ART Participants | 7.7 |
| D: Placebo Then Chloroquine for On-ART Participants | 9.0 |
Results reported are the week 24 percentage of CD4 expressing HLA-DR+/CD38+. (NCT00819390)
Timeframe: At Week 24
| Intervention | percent of CD4 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 11.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 12.5 |
| C: Chloroquine Then Placebo for On-ART Participants | 7.3 |
| D: Placebo Then Chloroquine for On-ART Participants | 9.2 |
Baseline CD8 CD38+ is computed as the mean of pre-entry and entry CD8 CD38+. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | percent of CD8 expressing CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 71.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 77.0 |
| C: Chloroquine Then Placebo for On-ART Participants | 50.8 |
| D: Placebo Then Chloroquine for On-ART Participants | 49.9 |
Results reported are the week 12 percentage of CD8 expressing CD38+. (NCT00819390)
Timeframe: At Week 12
| Intervention | percent of CD8 expressing CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 71.5 |
| B: Placebo Then Chloroquine for Off-ART Participants | 79.5 |
| C: Chloroquine Then Placebo for On-ART Participants | 50.9 |
| D: Placebo Then Chloroquine for On-ART Participants | 51.9 |
Results reported are the week 24 percentage of CD8 expressing CD38+. (NCT00819390)
Timeframe: At Week 24
| Intervention | percent of CD8 expressing CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 78.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 79.5 |
| C: Chloroquine Then Placebo for On-ART Participants | 50.6 |
| D: Placebo Then Chloroquine for On-ART Participants | 48.7 |
Baseline sCD14 was computed as the mean of pre-entry and entry sCD14. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | million pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 1.43 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.97 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.80 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.58 |
Results reported are the week 12 sCD14. (NCT00819390)
Timeframe: At week 12
| Intervention | million pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 1.53 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.88 |
| C: Chloroquine Then Placebo for On-ART Participants | 2.04 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.63 |
Results reported are the week 24 sCD14. (NCT00819390)
Timeframe: At week 24
| Intervention | million pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 1.53 |
| B: Placebo Then Chloroquine for Off-ART Participants | 2.19 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.77 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.72 |
Results reported are for HIV-1 RNA at study entry for on-ART participants. (NCT00819390)
Timeframe: At Entry
| Intervention | participants (Number) | |
|---|---|---|
| at or below lower limit of quantitation | above lower limit of quantitation | |
| C: Chloroquine Then Placebo for On-ART Participants | 16 | 2 |
| D: Placebo Then Chloroquine for On-ART Participants | 17 | 2 |
Results reported are for HIV-1 RNA at week 12 for on-ART participants. (NCT00819390)
Timeframe: At week 12
| Intervention | participants (Number) | |
|---|---|---|
| at or below lower limit of quantitation | above lower limit of quantitation | |
| C: Chloroquine Then Placebo for On-ART Participants | 16 | 1 |
| D: Placebo Then Chloroquine for On-ART Participants | 18 | 1 |
Results reported are for HIV-1 RNA at week 24 for on-ART participants. (NCT00819390)
Timeframe: At week 24
| Intervention | participants (Number) | |
|---|---|---|
| at or below lower limit of quantitation | above lower limit of quantitation | |
| C: Chloroquine Then Placebo for On-ART Participants | 14 | 2 |
| D: Placebo Then Chloroquine for On-ART Participants | 18 | 1 |
Results reported are for HIV-1 RNA (copies/mL) at week 12 and week 24 for off-ART participants. (NCT00819390)
Timeframe: At weeks 12 and 24
| Intervention | log10 copies/mL (Median) | |
|---|---|---|
| Week 12 | Week 24 | |
| A: Chloroquine Then Placebo for Off-ART Participants | 4.68 | 4.69 |
| B: Placebo Then Chloroquine for Off-ART Participants | 4.28 | 4.61 |
Baseline IL-6, sTNF-rI and D-dimer were computed as the mean of pre-entry and entry IL-6, sTNF-rI and D-dimer, respectively. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | pg/mL (Median) | ||
|---|---|---|---|
| IL-6 | sTNF-rI | D-dimer | |
| A: Chloroquine Then Placebo for Off-ART Participants | 1.65 | 1228.66 | 286390 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.62 | 1377.81 | 328460 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.01 | 1316.63 | 107890 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.51 | 1250.85 | 103530 |
Results reported are the week 12 IL-6, sTNF-rI and D-dimer. (NCT00819390)
Timeframe: At week 12
| Intervention | pg/mL (Median) | ||
|---|---|---|---|
| IL-6 | sTNF-rI | D-dimer | |
| A: Chloroquine Then Placebo for Off-ART Participants | 1.68 | 1209.50 | 251320 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.28 | 1347.06 | 319770 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.15 | 1441.35 | 126540 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.30 | 1304.77 | 117890 |
Results reported are the week 24 IL-6, sTNF-rI and D-dimer. (NCT00819390)
Timeframe: At week 24
| Intervention | pg/mL (Median) | ||
|---|---|---|---|
| IL-6 | sTNF-rI | D-dimer | |
| A: Chloroquine Then Placebo for Off-ART Participants | 1.34 | 1327.21 | 264240 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.18 | 1420.30 | 294780 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.02 | 1230.21 | 100860 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.27 | 1176.20 | 124920 |
Baseline percent activation levels of pDC were computed as the mean of pre-entry and entry percent activation levels of pDC. Similarly, baseline percent activation levels of mDC were computed as the mean of pre-entry and entry percent activation levels of mDC. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | percentage of cells (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| %pDC expressing CD80+ | %pDC expressing CD83+ | %pDC expressing CD86+ | %pDC expressing PDL-1+ | %mDC expressing CD80+ | %mDC expressing CD83+ | %mDC expressing CD86+ | %mDC expressing PDL-1+ | |
| A: Chloroquine Then Placebo for Off-ART Participants | 0.03 | 45.48 | 9.12 | 2.52 | 1.04 | 38.60 | 96.29 | 9.82 |
| B: Placebo Then Chloroquine for Off-ART Participants | 0.03 | 36.15 | 9.35 | 6.13 | 0.83 | 39.94 | 97.52 | 16.37 |
| C: Chloroquine Then Placebo for On-ART Participants | 0.13 | 19.91 | 10.96 | 4.48 | 1.31 | 48.17 | 96.11 | 4.58 |
| D: Placebo Then Chloroquine for On-ART Participants | 0.07 | 23.65 | 12.66 | 6.49 | 1.17 | 26.08 | 95.38 | 8.28 |
Results reported are the week 12 percent activation levels of pDC and mDC. (NCT00819390)
Timeframe: At week 12
| Intervention | percentage of cells (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| %pDC expressing CD80+ | %pDC expressing CD83+ | %pDC expressing CD86+ | %pDC expressing PDL-1+ | %mDC expressing CD80+ | %mDC expressing CD83+ | %mDC expressing CD86+ | %mDC expressing PDL-1+ | |
| A: Chloroquine Then Placebo for Off-ART Participants | 0.00 | 51.90 | 7.66 | 3.74 | 0.84 | 43.51 | 97.90 | 15.03 |
| B: Placebo Then Chloroquine for Off-ART Participants | 0.05 | 40.49 | 8.48 | 8.43 | 1.03 | 36.47 | 97.18 | 16.32 |
| C: Chloroquine Then Placebo for On-ART Participants | 0.10 | 14.70 | 13.93 | 7.24 | 1.47 | 47.83 | 95.40 | 7.10 |
| D: Placebo Then Chloroquine for On-ART Participants | 0.14 | 18.20 | 13.64 | 5.16 | 1.01 | 26.75 | 95.15 | 6.09 |
Results reported are the week 24 percent activation levels of pDC and mDC. (NCT00819390)
Timeframe: At week 24
| Intervention | percentage of cells (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| %pDC expressing CD80+ | %pDC expressing CD83+ | %pDC expressing CD86+ | %pDC expressing PDL-1+ | %mDC expressing CD80+ | %mDC expressing CD83+ | %mDC expressing CD86+ | %mDC expressing PDL-1+ | |
| A: Chloroquine Then Placebo for Off-ART Participants | 0.05 | 44.50 | 10.13 | 4.34 | 0.94 | 41.21 | 97.70 | 9.53 |
| B: Placebo Then Chloroquine for Off-ART Participants | 0.00 | 38.96 | 7.89 | 7.45 | 1.12 | 33.19 | 97.05 | 14.84 |
| C: Chloroquine Then Placebo for On-ART Participants | 0.08 | 14.80 | 11.79 | 5.63 | 0.76 | 36.65 | 96.69 | 4.13 |
| D: Placebo Then Chloroquine for On-ART Participants | 0.16 | 17.65 | 12.88 | 6.52 | 1.39 | 24.14 | 92.41 | 7.49 |
196 reviews available for chloroquine and Malaria
| Article | Year |
|---|---|
Recent advances in malaria drug discovery.
Topics: Animals; Antimalarials; Drug Discovery; Humans; Liver; Liver Transplantation; Malaria; Molecular Str | 2013 |
Reemergence of chloroquine (CQ) analogs as multi-targeting antimalarial agents: a review.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria | 2015 |
Quinoline-based antimalarial hybrid compounds.
Topics: Animals; Antimalarials; Drug Discovery; Humans; Malaria; Plasmodium; Quinolines | 2015 |
From hybrid compounds to targeted drug delivery in antimalarial therapy.
Topics: Aminoquinolines; Animals; Antimalarials; Drug Delivery Systems; Drug Discovery; Drug Resistance; Hum | 2015 |
New dimensions in the field of antimalarial research against malaria resurgence.
Topics: Animals; Antimalarials; Artemisinins; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 2019 |
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular St | 2020 |
An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins.
Topics: Animals; Antimalarials; Drug Development; Drug Resistance; Humans; Malaria; Molecular Targeted Thera | 2021 |
Structural-activity Relationship of Metallo-aminoquines as Next Generation Antimalarials.
Topics: Aminoquinolines; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Malaria; Plasmodium; P | 2022 |
Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review.
Topics: Africa South of the Sahara; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, F | 2022 |
Action mechanisms of metallic compounds on Plasmodium spp.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Parasitemia; Plasmodium | 2022 |
A contemporary chemical entities infiltrating in the antimalarial therapy era: a comprehensive review.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria; Pregnancy | 2021 |
Diagnosis, Treatment, and Prevention of Malaria in the US: A Review.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Humans; Malaria; Malar | 2022 |
Global scenario of Plasmodium vivax occurrence and resistance pattern.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Vivax; Plasmodium vivax; Primaquine | 2022 |
New Strategies in the Treatment of
Topics: Antimalarials; Chloroquine; Humans; Malaria; Nanoparticles; Plasmodium berghei | 2023 |
Recent developments in antimalarial drug discovery.
Topics: Antimalarials; Chloroquine; Drug Resistance; Folic Acid Antagonists; Humans; Malaria; Malaria, Falci | 2023 |
Transition Metal Complexes as Antimalarial Agents: A Review.
Topics: Antimalarials; Chloroquine; Coordination Complexes; Drug Resistance; Humans; Malaria; Malaria, Falci | 2023 |
Pyronaridine: a review of its clinical pharmacology in the treatment of malaria.
Topics: Antimalarials; Child; Chloroquine; Female; Humans; Malaria; Malaria, Falciparum; Naphthyridines; Pre | 2023 |
Ferrocene-Based Compounds with Antimalaria/Anticancer Activity.
Topics: Aminoquinolines; Antimalarials; Antineoplastic Agents; Chloroquine; Drug Resistance, Neoplasm; Drug | 2019 |
Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties.
Topics: Adult; Antimalarials; Child; Chloroquine; Coronavirus Infections; COVID-19; Drug Repositioning; Huma | 2020 |
Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments.
Topics: Aminoquinolines; Antimalarials; Chloroquine; Coordination Complexes; Ferrous Compounds; Humans; Mala | 2020 |
Insights in Chloroquine Action: Perspectives and Implications in Malaria and COVID-19.
Topics: Animals; Antimalarials; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVI | 2020 |
Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection.
Topics: Age Factors; Aging; Antiviral Agents; Chloroquine; Clinical Trials, Phase II as Topic; Clinical Tria | 2020 |
The host targeting effect of chloroquine in malaria.
Topics: Animals; Chloroquine; COVID-19 Drug Treatment; Humans; Hydroxychloroquine; Malaria; Pandemics; SARS- | 2020 |
Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19.
Topics: Animals; Antimalarials; Antirheumatic Agents; Antiviral Agents; Betacoronavirus; Chloroquine; Corona | 2020 |
Malaria and COVID-19: unmasking their ties.
Topics: Age Factors; Angiotensin-Converting Enzyme 2; Chloroquine; COVID-19; COVID-19 Drug Treatment; Humans | 2020 |
Drug treatment and prevention of malaria in pregnancy: a critical review of the guidelines.
Topics: Adult; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artesunate; Chloroquine | 2021 |
Mefloquine as a prophylaxis for malaria needs to be revisited.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Mefloquine; Military Personnel | 2021 |
Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries.
Topics: Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Ma | 2018 |
Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antimalarials; Antineoplastic Agents; Antirheumatic | 2018 |
Malaria Elimination: Time to Target All Species.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Disease Eradication; Host-Parasite Interactions; Hum | 2018 |
Itching, chloroquine, and malaria: a review of recent molecular and neuroscience advances and their contribution to mechanistic understanding and therapeutics of chronic non-histaminergic pruritus.
Topics: Action Potentials; Antimalarials; Antipruritics; Black People; Calcium; Chloroquine; Chronic Disease | 2019 |
Chloroquine: modes of action of an undervalued drug.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chloroquine; Drug Resistance, Bacterial; Eye; Human | 2013 |
Amazonian plant natural products: perspectives for discovery of new antimalarial drug leads.
Topics: Antimalarials; Artemisia annua; Biological Products; Chloroquine; Drug Discovery; Humans; Malaria; P | 2013 |
Role of traditional antimalarial plants in the battle against the global malaria burden.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Global Health; Humans; Malaria; | 2013 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malarial hemozoin: from target to tool.
Topics: Animals; Chloroquine; Crystallization; Hemeproteins; Humans; Malaria | 2014 |
Antimalarial drug policy in India: past, present & future.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falcip | 2014 |
Antimalarial drug resistance in Africa: key lessons for the future.
Topics: Africa; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Drug | 2015 |
Novel approaches to whole sporozoite vaccination against malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Humans; Malaria; Malaria Vaccines | 2015 |
Novel approaches to whole sporozoite vaccination against malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Humans; Malaria; Malaria Vaccines | 2015 |
Novel approaches to whole sporozoite vaccination against malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Humans; Malaria; Malaria Vaccines | 2015 |
Novel approaches to whole sporozoite vaccination against malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Humans; Malaria; Malaria Vaccines | 2015 |
The Treatment of Plasmodium knowlesi Malaria.
Topics: Antimalarials; Artemisinins; Artesunate; Asia, Southeastern; Chloroquine; Coinfection; Humans; Malar | 2017 |
Digestomics: an emerging strategy for comprehensive analysis of protein catabolism.
Topics: Antimalarials; Chloroquine; Drug Resistance; Hemoglobins; Humans; Malaria; Plasmodium; Proteolysis; | 2017 |
The "pushmi-pullyu" of resistance to chloroquine in malaria.
Topics: Animals; Biological Transport; Chloroquine; Drug Resistance; History, 20th Century; Humans; Malaria; | 2017 |
Chloroquine: novel uses & manifestations.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Neoplasms; Virus Diseases | 2008 |
Early detection of macular changes with multifocal ERG in patients on antimalarial drug therapy.
Topics: Antimalarials; Chloroquine; Early Diagnosis; Electroretinography; Humans; Hydroxychloroquine; Malari | 2009 |
Malaria: prevention in travellers.
Topics: Administration, Oral; Animals; Antimalarials; Bedding and Linens; Chloroquine; Humans; Insect Repell | 2007 |
Seventy-five years of Resochin in the fight against malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; History, 20th Century; History, 21st Century; | 2009 |
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Design; Drug Interactions; Drug Sy | 2009 |
Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.
Topics: Animals; Chloroquine; Erythrocytes; Humans; Immune Evasion; Immune Tolerance; Immunization; Immunomo | 2010 |
Malaria: prevention in travellers.
Topics: Antimalarials; Bedding and Linens; Chloroquine; Humans; Malaria; Mefloquine; Primaquine; Travel | 2010 |
Pharmacokinetics of antimalarials in pregnancy: a systematic review.
Topics: Anti-Bacterial Agents; Antimalarials; Artemisinins; Atovaquone; Chloroquine; Drug Therapy, Combinati | 2011 |
Ocular toxicity in children exposed in utero to antimalarial drugs: review of the literature.
Topics: Antimalarials; Child; Chloroquine; Databases, Factual; Eye; Eye Diseases; Female; Humans; Hydroxychl | 2011 |
Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria.
Topics: Ajuga; Antimalarials; Artemisinins; Chloroquine; Dehydroepiandrosterone Sulfate; Diterpenes; Ergoste | 2011 |
Reversed chloroquine molecules as a strategy to overcome resistance in malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Membrane Transport Proteins; | 2012 |
From methylene blue to chloroquine: a brief review of the development of an antimalarial therapy.
Topics: Antimalarials; Chloroquine; Drug Therapy; History, 19th Century; History, 20th Century; History, 21s | 2012 |
Plasmodium knowlesi: from Malaysia, a novel health care threat.
Topics: Animals; Anopheles; Antimalarials; Asia, Southeastern; Chloroquine; Insect Vectors; Macaca; Malaria; | 2012 |
The malaria digestive vacuole.
Topics: Animals; Antimalarials; Chloroquine; Erythrocytes; Hemeproteins; Hemoglobins; Humans; Malaria; Plasm | 2012 |
Update on the in vivo tolerance and in vitro reduced susceptibility to the antimalarial lumefantrine.
Topics: Antimalarials; Asia, Southeastern; Chloroquine; Drug Resistance; Drug Tolerance; Ethanolamines; Fluo | 2012 |
Metal containing chloroquinolines: beyond hit and miss antimalarial efficacy to solid science.
Topics: Antimalarials; Chloroquine; Coordination Complexes; Ferrous Compounds; Humans; Malaria; Metallocenes | 2013 |
Plasmodium knowlesi: the emerging zoonotic malaria parasite.
Topics: Animals; Anopheles; Antimalarials; Borneo; Chloroquine; Communicable Diseases, Emerging; Geography; | 2013 |
Clindamycin as an antimalarial drug: review of clinical trials.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Clindamycin; Drug Combinations; Female; | 2002 |
Chemotherapeutic agents against malaria: what next after chloroquine?
Topics: Animals; Antimalarials; Artemisinins; Biological Factors; Chloroquine; Folic Acid Antagonists; Human | 2002 |
Current drugs for antimalarial chemoprophylaxis: a review of efficacy and safety.
Topics: Antimalarials; Atovaquone; Chloroquine; Doxycycline; Humans; Malaria; Mefloquine; Naphthoquinones; P | 2001 |
Malaria: a rising incidence in the United States.
Topics: Antimalarials; Chemoprevention; Chloroquine; Drug Combinations; Drug Resistance; Female; Global Heal | 2002 |
Clinical practice: antimalarial prophylaxis in patients with epilepsy [corrected].
Topics: Antimalarials; Chemoprevention; Chloroquine; Epilepsy; Humans; Malaria; Mefloquine; Risk Factors; Tr | 2002 |
Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Hemoglobins; Humans; Malaria; Models, Molecula | 2001 |
Can a proteomics strategy be used to identify the anti-malarial activity of chloroquine?
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Proteomics | 2003 |
THE PENDULUM IN MALARIA CHEMOTHERAPY: FROM QUININE TO CHLOROQUINE AND BACK TO QUININE?
Topics: Antimalarials; Biomedical Research; Chloroquine; Drug Resistance; Drug Resistance, Microbial; Humans | 1964 |
Military aviators, special operations forces, and causal malaria prophylaxis.
Topics: Aminoquinolines; Antimalarials; Atovaquone; Aviation; Chloroquine; Doxycycline; Drug Combinations; H | 2003 |
WHO, the Global Fund, and medical malpractice in malaria treatment.
Topics: Africa; Antimalarials; Artemisinins; Child; Chloroquine; Drug Combinations; Drug Costs; Drug Resista | 2004 |
Glutathione is involved in the antimalarial action of chloroquine and its modulation affects drug sensitivity of human and murine species of Plasmodium.
Topics: Acetylcysteine; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Glutathione; Hemi | 2003 |
Genetic and biochemical aspects of drug resistance in malaria parasites.
Topics: Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; Drug Resistance; Drug Resistance, Mul | 2004 |
[Combined antimalarial therapy using artemisinin].
Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Doxycycline; | 2004 |
[Malaria: prophylaxis, treatment, stand-by medication. A single mosquito bite suffices].
Topics: Adult; Antimalarials; Artemether; Artemisinins; Atovaquone; Chloroquine; Climate; Doxycycline; Drug | 2004 |
Malaria in endemic areas.
Topics: Antimalarials; Artemether; Artemisinins; Blood Transfusion; Chloroquine; Deferoxamine; Drug Combinat | 2003 |
Malaria: prevention in travellers.
Topics: Adult; Antimalarials; Atovaquone; Child; Chloroquine; Doxycycline; Female; Humans; Insect Repellents | 2003 |
Malaria: prevention in travellers.
Topics: Adult; Antimalarials; Atovaquone; Child; Chloroquine; Clothing; Doxycycline; Female; Humans; Insect | 2004 |
Effectiveness of antimalarial drugs.
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combination; | 2005 |
Fitness of drug-resistant malaria parasites.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Humans; Malaria; Mutation; Plasmodiu | 2005 |
Therapeutic drugs for targeting chloroquine resistance in malaria.
Topics: Animals; Antimalarials; Chelating Agents; Chloroquine; Drug Delivery Systems; Drug Resistance; Human | 2005 |
Malaria: prevention in travellers.
Topics: Adult; Antimalarials; Atovaquone; Child; Chloroquine; Clothing; Doxycycline; Female; Humans; Insect | 2004 |
Should chloroquine be laid to rest?
Topics: Adult; Africa; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Humans; Malaria; | 2005 |
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.
Topics: Adult; Amodiaquine; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Mala | 2005 |
Chemoprophylaxis and intermittent treatment for preventing malaria in children.
Topics: Antimalarials; Child, Preschool; Chloroquine; Dapsone; Humans; Infant; Malaria; Pyrimethamine; Rando | 2005 |
Malaria: burden of disease.
Topics: Chloroquine; DDT; Drug Resistance; Humans; Incidence; Insecticides; Malaria; Malaria Vaccines; Preva | 2006 |
[Cytochrome P-450 and the response to antimalarial drugs].
Topics: Administration, Oral; Adult; Amodiaquine; Animals; Antimalarials; Biotransformation; Child; Chloroqu | 2006 |
[Epidemiology and prevention of malaria in the southwestern islands of the Indian Ocean].
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Comoros; Drug Resistance; Humans; Indian Ocean Islan | 2006 |
Current malaria status and distribution of drug resistance in East and Southeast Asia with special focus to Thailand.
Topics: Age Factors; Animals; Antimalarials; Artemisinins; Asia, Southeastern; Chloroquine; Drug Resistance; | 2007 |
Recent developments in naturally derived antimalarials: cryptolepine analogues.
Topics: Animals; Antimalarials; Chloroquine; Cryptolepis; Drug Resistance; Humans; Indole Alkaloids; Malaria | 2007 |
Drug-resistant malaria - an insight.
Topics: Animals; Antimalarials; Artemisinins; Atovaquone; Chloroquine; Drug Resistance; Folic Acid Antagonis | 2007 |
Assessment of the relative advantage of various artesunate-based combination therapies by a multi-treatment Bayesian random-effects meta-analysis.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Bayes Theorem; C | 2007 |
Clinical inquiries. What is the most effective and safe malaria prophylaxis during pregnancy?
Topics: Abnormalities, Drug-Induced; Antimalarials; Chemoprevention; Chloroquine; Doxycycline; Female; Human | 2008 |
Malaria prophylaxis in travellers: the current position.
Topics: Africa; Amodiaquine; Antimalarials; Asia; Chloroquine; Culicidae; Drug Resistance; Female; Humans; I | 1984 |
Resistance of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Asia; Chloroquine; DNA; Drug Resistance; Drug Synergism; Hemin; Mala | 1984 |
Malaria--resurgence, resistance, and research. (First of two parts).
Topics: Antimalarials; Chloroquine; DDT; Drug Resistance, Microbial; Europe; Female; Humans; Malaria; Mosqui | 1983 |
[Progress in immunodiagnosis and chemotherapy of protozoan infections].
Topics: Amebiasis; Animals; Antibodies; Babesiosis; Chloroquine; Drug Resistance, Microbial; Giardiasis; Hum | 1983 |
Malaria 1984. Part I. Malaria prophylaxis.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Microbial; Female; Humans; | 1984 |
Malaria 1984. Part II. Drug-resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium | 1984 |
Practical therapeutics malaria chemoprophylaxis.
Topics: Adult; Africa, Eastern; Aminoquinolines; Antimalarials; Child; Chloroquine; Drug Combinations; Drug | 1984 |
[Malaria in pregnant women. Presentation of 2 cases and review of the literature].
Topics: Abortion, Spontaneous; Acute Kidney Injury; Adult; Anemia, Hemolytic; Antimalarials; Brain Diseases; | 1982 |
Chemoprophylaxis of malaria in Africa: the spent "magic bullet".
Topics: Africa; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Ma | 1982 |
[Drug resistance in malaria].
Topics: Africa; Amodiaquine; Animals; Asia; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmo | 1980 |
The genetics of drug resistance in malaria parasites.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Malaria; Plasmodium; Pyrimethamine; Rodentia | 1980 |
The present status of malaria chemotherapy: mefloquine, a novel antimalarial.
Topics: Amodiaquine; Animals; Antimalarials; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine; | 1981 |
Antimalarial drug resistance: an increasing problem.
Topics: Aminoquinolines; Animals; Antimalarials; Aotus trivirgatus; Chloroquine; Drug Resistance, Microbial; | 1982 |
Advances in chemotherapy.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Evaluation, Preclinical; Drug Therapy, Combi | 1982 |
Parasite-regulated membrane transport processes and metabolic control in malaria-infected erythrocytes.
Topics: Adenosine Triphosphatases; Amino Acids; Animals; Chloroquine; Choline; Drug Resistance, Multiple; Er | 1995 |
[Current malaria management in Switzerland].
Topics: Adult; Animals; Antimalarials; Chloroquine; Critical Care; Drug Resistance; Female; Humans; Malaria; | 1994 |
Immunoliposomes in vivo.
Topics: Amphotericin B; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Biological Availability; Can | 1994 |
The use of chloroquine during pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Chloroquine; Female; Humans; Malaria; Pregnancy; Pregnancy Com | 1994 |
Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations.
Topics: Chloroquine; Diethylcarbamazine; Drug Resistance; Echinococcosis; Filariasis; Humans; Malaria; Meflo | 1994 |
[Epidemiological stratification of malaria in Madagascar].
Topics: Agriculture; Animals; Anopheles; Chloroquine; Emigration and Immigration; Humans; Insect Vectors; Ma | 1993 |
Clinical malaria in the tropics.
Topics: Africa; Antimalarials; Asia, Southeastern; Chloroquine; Combined Modality Therapy; Drug Resistance; | 1993 |
[Malaria: the most important emergency in subjects returning from the tropics].
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Emergencies; Humans; Malaria; Malaria, Falci | 1993 |
Prophylaxis against malaria for travellers from the United Kingdom. Malaria Reference Laboratory and the Ross Institute.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; H | 1993 |
[Malaria and drug resistance].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Microbial Sensitivity Tests; | 1996 |
The treatment of malaria.
Topics: Adult; Antimalarials; Artemisinins; Child; Chloroquine; Drug Resistance; Female; Humans; Malaria; Ma | 1996 |
Molecular approaches to the spreading problem of drug resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Chromosome Mapping; DNA Fingerprinting; DNA, Protozoan; Drug Re | 1995 |
Chloroquine-induced vitiligo. A case report and review of the literature.
Topics: Antimalarials; Child; Chloroquine; Female; Humans; Malaria; Vitiligo | 1996 |
Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Stereoisomerism; Tissue Distribution | 1996 |
The safety of antimalarial drugs in pregnancy.
Topics: Animals; Anti-Infective Agents; Antimalarials; Chloroquine; Contraindications; Female; Folic Acid An | 1996 |
[Chloroquine maculopathy and prevention of malaria].
Topics: Adult; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Female; Humans; Macula Lutea; M | 1996 |
[The treatment of malaria].
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Malar | 1997 |
Involvement of heme in the antimalarial action of chloroquine.
Topics: Animals; Antimalarials; Chloroquine; Digestion; Drug Resistance; Erythrocytes; Heme; Hemeproteins; H | 1998 |
[Malaria therapy in the era of chloroquine resistance].
Topics: Antimalarials; Chloroquine; Clinical Trials as Topic; Drug Resistance; Drug Therapy, Combination; Hu | 1998 |
Malaria prevention in travelers.
Topics: Animals; Antimalarials; Bedding and Linens; Chloroquine; Doxycycline; Humans; Malaria; Malaria, Falc | 1999 |
Making malaria-treatment policy in the face of drug resistance.
Topics: Africa South of the Sahara; Antimalarials; Asia, Southeastern; Chloroquine; Community Health Service | 1999 |
The evolution of tafenoquine--antimalarial for a new millennium?
Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Primaquine | 1999 |
Heme metabolism of Plasmodium is a major antimalarial target.
Topics: 5-Aminolevulinate Synthetase; Animals; Antimalarials; Chloroquine; Erythrocytes; Heme; Humans; Malar | 2000 |
Chemotherapeutic malaria control as a selective primary health care activity in the Solomon Islands.
Topics: Adult; Antimalarials; Child; Chloroquine; Humans; Malaria; Melanesia; Primaquine; Primary Prevention | 1999 |
Comparative efficacy and safety of chloroquine and alternative antimalarial drugs: a meta-analysis from six African countries.
Topics: Africa, Eastern; Africa, Western; Amodiaquine; Antimalarials; Chloroquine; Drug Combinations; Drug C | 1999 |
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.
Topics: Adult; Amodiaquine; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Mala | 2000 |
[Malaria in Norway--diagnosis, treatment and prevention].
Topics: Antimalarials; Chloroquine; Humans; Insect Bites and Stings; Malaria; Malaria, Falciparum; Mefloquin | 2000 |
Spontaneous rupture of malarial spleen: two case reports and review of literature.
Topics: Acute Disease; Adult; Antimalarials; Chloroquine; Endemic Diseases; Humans; Incidence; Malaria; Male | 2000 |
Combination therapy for malaria in Africa: hype or hope?
Topics: Africa; Antimalarials; Artemisinins; Artesunate; Asia, Southeastern; Chloroquine; Cross-Cultural Com | 2000 |
[Recommendations for prevention of malaria in patients with epilepsy].
Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Electroencephalography; Epilepsy; Female; Human | 2001 |
[Malaria--chemoprophylaxis 2001].
Topics: Africa; Antimalarials; Asia; Atovaquone; Chloroquine; Contraindications; Doxycycline; Drug Combinati | 2001 |
Chloroquine-resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Plasmodium; Plasmodium fa | 2001 |
[Malaria].
Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Diagnosis, Differential; Humans; Mala | 2001 |
The Italian army standpoint on malaria chemoprophylaxis.
Topics: Antimalarials; Chloroquine; Doxycycline; Drug Resistance; Drug Therapy, Combination; Endemic Disease | 2001 |
The malaria threat.
Topics: Antimalarials; Chloroquine; Doxycycline; Drug Resistance; Health Policy; Humans; Malaria; Malaria, F | 2001 |
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.
Topics: Adult; Amodiaquine; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Mala | 2001 |
Combating malaria in Africa.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Ins | 2002 |
[Chloroquine--miscellaneous properties of the antimalarial drug].
Topics: Animals; Antimalarials; Arthritis, Rheumatoid; Chloroquine; Humans; Lupus Vulgaris; Malaria; Porphyr | 2002 |
[Present condition and problems of malaria].
Topics: Chloroquine; Drug Combinations; Drug Synergism; Humans; Malaria; Pyrimethamine; Sulfanilamides | 1978 |
[Current information on treatment and prophylaxis of malaria (author's transl)].
Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Dr | 1979 |
The treatment of severe falciparum malaria.
Topics: Adult; Antimalarials; Chloroquine; Erythrocytes; Humans; Infusions, Parenteral; Malaria; Male; Plasm | 1977 |
The treatment of malaria.
Topics: Anemia; Antimalarials; Blackwater Fever; Child; Child, Preschool; Chloroquine; Coma; Drug Combinatio | 1976 |
[Treatment of intestinal parasitosis].
Topics: Amphotericin B; Anthelmintics; Bithionol; Cestode Infections; Chloroquine; Humans; Intestinal Diseas | 1975 |
Cerebral Malaria.
Topics: Adolescent; Adult; Antimalarials; Brain Diseases; Capillaries; Cerebral Cortex; Cerebral Hemorrhage; | 1975 |
Does chloroquine cause seizures? Presentation of three new cases and a review of the literature.
Topics: Adult; Chloroquine; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; Lupus Erythemato | 1992 |
Trends and controversies in the prophylaxis and treatment of malaria.
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Mefloquine | 1992 |
Neurological sequelae of cerebral malaria in children.
Topics: Adolescent; Animals; Antimalarials; Brain Diseases; Child; Chloroquine; Coma; Follow-Up Studies; Gam | 1990 |
[Current drugs for the treatment of tropical malaria].
Topics: Animals; Antimalarials; Chloroquine; Clinical Trials as Topic; Drug Resistance; Humans; Malaria; Pla | 1991 |
Drug resistance in malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1990 |
Drugs that reverse chloroquine resistance in malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria | 1990 |
Therapeutics review: the use of parenteral drugs for falciparum malaria.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Humans; Infusions, Intravenous; Injections, Intram | 1990 |
Malaria in Leicester 1983-1988: a review of 114 cases.
Topics: Adolescent; Adult; Animals; Chloroquine; England; Female; Humans; Malaria; Male; Plasmodium falcipar | 1990 |
Risks and benefits of prophylactic antimalarial drugs.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Mefloquine; Proguanil; Risk Factors | 1989 |
Mechanisms of enhanced pruritogenicity of chloroquine among patients with malaria: a review.
Topics: Child, Preschool; Chloroquine; Drug Eruptions; Female; Humans; Infant; Malaria; Male; Pruritus; Skin | 1989 |
Malaria--an overview.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Malaysia; Plasmodium falcipar | 1989 |
The spread of chloroquine-resistant malaria in Africa. Implications for travelers.
Topics: Africa; Animals; Chloroquine; Democratic Republic of the Congo; Drug Resistance; Malaria; Plasmodium | 1989 |
Ferriprotoporphyrin IX: role in chloroquine susceptibility and resistance in malaria.
Topics: Animals; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Hemoglobins; Malaria; Plasmodium; | 1989 |
Treatment of severe malaria.
Topics: Animals; Antimalarials; Chloroquine; Critical Care; Drug Resistance; Female; Humans; Malaria; Plasmo | 1989 |
[Malaria and pregnancy. Report of a case of congenital Plasmodium falciparum malaria].
Topics: Chloroquine; Diagnosis, Differential; Female; Humans; Infant, Newborn; Malaria | 1989 |
Extension of multiple drug resistant Plasmodium falciparum malaria in Africa: report of a Central African case.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparum; Pyrimeth | 1989 |
Mechanisms of chloroquine resistance in malarial chemotherapy.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Humans; Malaria | 1988 |
The current status of drug resistance in malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium | 1987 |
The chemoprophylaxis of malaria.
Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Malaria; Plasmodium | 1987 |
[Resistance of Plasmodium falciparum to 4-aminoquinolines. A review based on the Madagascar experience].
Topics: Animals; Chloroquine; Drug Resistance; Humans; Madagascar; Malaria; Plasmodium falciparum | 1987 |
The antimalarial action of chloroquine and mechanisms of resistance.
Topics: Chloroquine; Drug Resistance; Humans; Malaria | 1987 |
Chemoprophylaxis of malaria.
Topics: Adolescent; Adult; Africa; Anemia, Hemolytic; Asia; Australia; Child; Child, Preschool; Chloroquine; | 1986 |
Use of pyrimethamine-sulfadoxine (Fansidar) in prophylaxis against chloroquine-resistant Plasmodium falciparum and Pneumocystis carinii.
Topics: Acquired Immunodeficiency Syndrome; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria | 1987 |
The problem of drug resistance in malaria.
Topics: Africa; Animals; Antimalarials; Artemisinins; Chemical Phenomena; Chemistry; Chloroquine; Clinical T | 1985 |
Transfusion associated parasitic infections.
Topics: Animals; Babesiosis; Blood Donors; Blood Transfusion; Carrier State; Chagas Disease; Chloroquine; He | 1985 |
Malaria--recent progress and problems.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Fluorescent Antibody Technique; gamma-Globul | 1967 |
Recent advances in antimalarial chemotherapy and drug resistance.
Topics: Agglutination; Amodiaquine; Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Cross Reacti | 1974 |
Drug therapy. Treatment of common parasitic infections of man encountered in the United States. 2.
Topics: Amebiasis; Amebicides; Anthelmintics; Antimalarials; Antimony; Benzenesulfonates; Chloroquine; Clono | 1972 |
The present status of chloroquine in the drug treatment of malaria.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium; Primaquine; Proguanil; Pyrimet | 1972 |
Summary of recent abstracts. 3. Malaria. 2.
Topics: Animals; Antimalarials; Birds; Chloroquine; Dapsone; Humans; India; Malaria; Malaria, Avian; Mammals | 1972 |
The problem of drug-resistant malaria.
Topics: Amodiaquine; Anopheles; Antimalarials; Asia; Chloroquine; Drug Resistance, Microbial; Humans; Insect | 1972 |
Development of new antimalarial drugs.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Folic Acid Antagonists; Humans; | 1972 |
[Problems of malaria therapy].
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium; Plasmodium falciparum | 1972 |
A review of the drug sensitivity of Plasmodium falciparum in Thailand.
Topics: Chloroquine; Drug Resistance; Geography; Humans; Malaria; Methylamines; Naphthacenes; Plasmodium fal | 1972 |
Summary of recent abstracts. 3. Malaria.2.
Topics: Animals; Carbon Isotopes; Chloroquine; Dapsone; DNA; Drug Resistance, Microbial; Humans; Malaria; Or | 1973 |
Antimalarial drugs and their actions.
Topics: Antimalarials; Chloroquine; Drug Compounding; Drug Resistance, Microbial; Humans; Malaria; Plasmodiu | 1973 |
[Importation of malaria into the Federal Republic of Germany including Berlin (West) in the last ten years (1963-1972)].
Topics: Africa; Age Factors; Aircraft; Amodiaquine; Antimalarials; Asia; Berlin; Chloroquine; Disease Outbre | 1974 |
[The immunofluorescence reaction in the seroimmunological study of malaria].
Topics: Africa; Age Factors; Antibodies; Antigens; Blood Donors; Chloroquine; Cross Reactions; Epidemiologic | 1974 |
New perspectives on the chemotherapy of malaria, filariasis, and leprosy.
Topics: Amodiaquine; Aniline Compounds; Antimalarials; Chloroquine; Cresols; Dapsone; Drug Resistance; Filar | 1974 |
The metabolism of the malaria parasite and its host.
Topics: Aerobiosis; Animals; Carbon Dioxide; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Glucose; | 1972 |
Advances in the treatment of tropical diseases.
Topics: Acute Kidney Injury; Amebiasis; Antimalarials; Ascariasis; Chloroquine; Dexamethasone; Drug Resistan | 1968 |
The pharmacology of the antimalarials. A rational approach to the therapy of resistant falciparum malaria.
Topics: Amodiaquine; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Dapsone; Drug Resistance, Mi | 1969 |
Drug resistance in malaria--a perspective.
Topics: Adult; Africa; Animals; Antimalarials; Asia, Southeastern; Child; Chloroquine; Drug Resistance, Micr | 1969 |
Chemotherapy of the drug-resistant malarias.
Topics: Chloroquine; Cinchona; Drug Resistance, Microbial; Malaria; Mutation; Phytotherapy; Plants, Medicina | 1969 |
Malaria treatment and prevention. A review.
Topics: Adolescent; Adult; Africa, Eastern; Antimalarials; Biguanides; Child; Child, Preschool; Chloroquine; | 1969 |
Malaria. Chemoprophylaxis and chemotherapy.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Drug Synergism; Humans | 1971 |
Symposium. The role of serum antibodies in malarial immunity. The detection and measurement of malarial antibodies.
Topics: Agglutination Tests; Animals; Antibodies; Antibody Formation; Blood; Chloroquine; Complement Fixatio | 1971 |
177 trials available for chloroquine and Malaria
| Article | Year |
|---|---|
Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Malaria, Vivax | 2023 |
Use of malaria rapid diagnostic tests by community health workers in Afghanistan: cluster randomised trial.
Topics: Adolescent; Afghanistan; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Communit | 2017 |
Artemether-Lumefantrine Versus Chloroquine for the Treatment of Uncomplicated Plasmodium knowlesi Malaria: An Open-Label Randomized Controlled Trial CAN KNOW.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemether, Lumefantrine Drug Combination; Child; Child, Pre | 2018 |
Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.
Topics: Adult; Alkynes; Anti-Retroviral Agents; Antimalarials; Antiretroviral Therapy, Highly Active; Benzox | 2018 |
Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Female; Humans; Infant, Newborn; Malaria; Preg | 2018 |
Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Female; Humans; Infant, Newborn; Malaria; Preg | 2018 |
Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Female; Humans; Infant, Newborn; Malaria; Preg | 2018 |
Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Female; Humans; Infant, Newborn; Malaria; Preg | 2018 |
Creative solutions to extraordinary challenges in clinical trials: methodology of a phase III trial of azithromycin and chloroquine fixed-dose combination in pregnant women in Africa.
Topics: Africa; Antimalarials; Azithromycin; Chloroquine; Drug Combinations; Female; Humans; Malaria; Pregna | 2013 |
Chloroquine-azithromycin combination antimalarial treatment decreases risk of respiratory- and gastrointestinal-tract infections in Malawian children.
Topics: Antimalarials; Azithromycin; Child, Preschool; Chloroquine; Drug Therapy, Combination; Female; Gastr | 2014 |
Pharmacokinetic interactions between primaquine and chloroquine.
Topics: Adult; Antimalarials; Chloroquine; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Ma | 2014 |
A study protocol for a randomised open-label clinical trial of artesunate-mefloquine versus chloroquine in patients with non-severe Plasmodium knowlesi malaria in Sabah, Malaysia (ACT KNOW trial).
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Female; Humans; Malaria; Malaysia; Male; Meflo | 2014 |
Sulphadoxine-pyrimethamine plus azithromycin for the prevention of low birthweight in Papua New Guinea: a randomised controlled trial.
Topics: Adult; Antimalarials; Azithromycin; Chloroquine; Drug Combinations; Female; Humans; Infant, Low Birt | 2015 |
Artesunate-mefloquine versus chloroquine for treatment of uncomplicated Plasmodium knowlesi malaria in Malaysia (ACT KNOW): an open-label, randomised controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artes | 2016 |
Comparison of the safety and efficacy of fixed-dose combination of arterolane maleate and piperaquine phosphate with chloroquine in acute, uncomplicated Plasmodium vivax malaria: a phase III, multicentric, open-label study.
Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Heterocyclic | 2016 |
Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Malaria; Male; Mice; Parasitemia; Penta | 2016 |
TSCQ study: a randomized, controlled, open-label trial of daily trimethoprim-sulfamethoxazole or weekly chloroquine among adults on antiretroviral therapy in Malawi: study protocol for a randomized controlled trial.
Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Retroviral Agents; Antimalarials; | 2016 |
Efficacy of Chloroquine for the Treatment of Vivax malaria in Northwest Ethiopia.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Ethiopia; Female; Foll | 2016 |
[Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006].
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Colombia; Drug Combinati | 2008 |
A community effectiveness trial of strategies promoting intermittent preventive treatment with sulphadoxine-pyrimethamine in pregnant women in rural Burkina Faso.
Topics: Adolescent; Adult; Antimalarials; Burkina Faso; Chloroquine; Drug Combinations; Female; Health Promo | 2008 |
Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial.
Topics: Anemia, Sickle Cell; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Administration Schedu | 2009 |
Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial.
Topics: Anemia, Sickle Cell; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Administration Schedu | 2009 |
Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial.
Topics: Anemia, Sickle Cell; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Administration Schedu | 2009 |
Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial.
Topics: Anemia, Sickle Cell; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Administration Schedu | 2009 |
Active malaria morbidity management has limited impact on height status of preschool Senegalese children.
Topics: Antimalarials; Body Height; Child, Preschool; Chloroquine; Drug Combinations; Female; Growth Disorde | 2010 |
Doxycycline-chloroquine vs. doxycycline-placebo for malaria prophylaxis in nonimmune soldiers: a double-blind randomized field trial in sub-Saharan Africa.
Topics: Adult; Africa South of the Sahara; Antimalarials; Chloroquine; Double-Blind Method; Doxycycline; Dru | 2010 |
Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections.
Topics: Administration, Oral; Adult; Antimalarials; Borneo; Chloroquine; Drug Therapy, Combination; Female; | 2010 |
A comparison of iron and folate with folate alone in hematologic recovery of children treated for acute malaria.
Topics: Anemia; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Therapy, Combination; | 2010 |
Prevention of malaria during pregnancy: assessing the effect of the distribution of IPTp through the national policy in Benin.
Topics: Adult; Antimalarials; Benin; Chloroquine; Drug Combinations; Female; Health Policy; HIV Infections; | 2011 |
A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria.
Topics: Antimalarials; Artemisinins; Artesunate; Atovaquone; Azithromycin; Child, Preschool; Chloroquine; Dr | 2012 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Can mothers be trusted to give malaria treatment to their children at home?
Topics: Adolescent; Adult; Antimalarials; Child; Child Care; Child, Preschool; Chloroquine; Female; Guinea-B | 2003 |
Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study.
Topics: Adolescent; Antimalarials; Atovaquone; Child; Child, Preschool; Chloroquine; Drug Therapy, Combinati | 2004 |
Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of malaria during pregnancy in Mali.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anemia; Birth Weight; Chemoprevention; Chloroquine; Drug A | 2005 |
Comparison of sulfadoxine-pyrimethamine with and without chloroquine for uncomplicated malaria in Nigeria.
Topics: Adolescent; Adult; Antimalarials; Body Weight; Child; Chloroquine; Drug Therapy, Combination; Female | 2005 |
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.
Topics: Amodiaquine; Antimalarials; Artemisinins; Child, Preschool; Chloroquine; Drug Combinations; Drug The | 2005 |
Improving access to early treatment of malaria: a trial with primary school teachers as care providers.
Topics: Antimalarials; Attitude to Health; Child; Chloroquine; Drug Packaging; Faculty; Ghana; Health Educat | 2005 |
The importance of the period of malarial infection during pregnancy on birth weight in tropical Africa.
Topics: Adolescent; Adult; Africa; Animals; Antimalarials; Birth Weight; Burkina Faso; Chloroquine; Female; | 2007 |
Home-based management of fever and malaria treatment practices in Uganda.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Services; Drug Combinations; D | 2007 |
Short report: prevalence and chloroquine sensitivity of Plasmodium malariae in Madagascar.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Inf | 2007 |
[Comparative impact of three malaria preventive regimens during pregnancy on maternal anemia due to malaria in Burkina Faso].
Topics: Adult; Anemia; Antimalarials; Burkina Faso; Chloroquine; Drug Therapy, Combination; Female; Humans; | 2008 |
Efficacy of intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine in preventing anaemia in pregnancy among Nigerian women.
Topics: Adolescent; Adult; Anemia; Antimalarials; Chloroquine; Drug Combinations; Female; Humans; Malaria; N | 2008 |
Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial.
Topics: Anemia; Animals; Burkina Faso; Child, Preschool; Chloroquine; Female; Fever; Humans; Infant; Malaria | 2008 |
In-vivo and in-vitro assessment of chloroquine-resistant Plasmodium falciparum malaria in Zanzibar.
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Malari | 1983 |
Effectiveness of amodiaquine as treatment for chloroquine-resistant Plasmodium falciparum infections in Kenya.
Topics: Adolescent; Amodiaquine; Blood; Child; Chloroquine; Drug Combinations; Drug Resistance, Microbial; F | 1984 |
Amodiaquine more effective than chloroquine against Plasmodium falciparum malaria on Kenya coast.
Topics: Amodiaquine; Child; Chloroquine; Humans; Kenya; Malaria; Plasmodium falciparum | 1984 |
Tolerability of long-term prophylaxis with fansidar: a randomized double-blind study in Nigeria.
Topics: Adolescent; Adult; Antimalarials; Blood Cell Count; Chloroquine; Clinical Trials as Topic; Double-Bl | 1984 |
In vivo and in vitro sensitivity of Falciparum malaria to quinine in Thai children.
Topics: Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance, Microbial; | 1981 |
A phase II clinical trial of mefloquine in patients with chloroquine-resistant falciparum malaria in Thailand.
Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Clinical Trials as Topic; Double-Blind Method; | 1983 |
A double-blind comparative clinical trial of mefloquine and chloroquine in symptomatic falciparum malaria.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Clinical Trials as Topic; Double-Blind Metho | 1983 |
A controlled trial of a combination of chloroquine with paracetamol in the treatment of acute malaria in a semi-immune population.
Topics: Acetaminophen; Adolescent; Adult; Child; Chloroquine; Clinical Trials as Topic; Female; Humans; Mala | 1980 |
A clinical trial of malaria prophylaxis using a single dose of chloroquine at different intervals in an endemic malarious area.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Clinical Trials as Topic; Female; Humans; I | 1980 |
Chemotherapy of malaria.
Topics: Asia, Southeastern; Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; Hyper | 1981 |
The in vivo sensitivity of Plasmodium falciparum to chloroquine and to sulphadoxine-pyrimethamine combination in Ibadan, Nigeria.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance, Microbial; | 1981 |
Sulfadoxine-pyrimethamine for the treatment of acute malaria in children in Papua New Guinea. I. Plasmodium falciparum.
Topics: Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; | 1982 |
Sulfadoxine-pyrimethamine for the treatment of acute malaria in children of Papua New Guinea. II. Plasmodium vivax.
Topics: Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; | 1982 |
A comparative trial of oral chloroquine and oral co-trimoxazole in vivax malaria in children.
Topics: Administration, Oral; Child; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug Combinati | 1982 |
The present status of malaria chemotherapy: mefloquine, a novel antimalarial.
Topics: Amodiaquine; Animals; Antimalarials; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine; | 1981 |
Sensitivity of Plasmodium falciparum to chloroquine in Busia District, Kenya.
Topics: Adolescent; Child; Chloroquine; Humans; Kenya; Malaria; Microbial Sensitivity Tests; Plasmodium falc | 1982 |
The treatment of malaria in glucose-6-phosphate dehydrogenase deficient patients in Sabah.
Topics: Adolescent; Adult; Anemia, Hemolytic; Antimalarials; Child; Chloroquine; Drug Combinations; Female; | 1981 |
The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria.
Topics: Adolescent; Adult; Antimalarials; Antipruritics; Chloroquine; Chlorpheniramine; Cyproheptadine; Derm | 1995 |
Malaria prophylaxis. Toxicity of mefloquine is similar to that of other chemoprophylaxis.
Topics: Chloroquine; Double-Blind Method; Humans; Malaria; Mefloquine; Proguanil | 1995 |
Testing strategies to increase use of chloroquine chemoprophylaxis during pregnancy in Malaŵi.
Topics: Chemistry, Pharmaceutical; Chloroquine; Effect Modifier, Epidemiologic; Female; Follow-Up Studies; H | 1994 |
Severe morbidity among children in a trial malaria chemoprophylaxis with pyrimethamine or chloroquine in Ibarapa, Nigeria.
Topics: Age Factors; Child, Preschool; Chloroquine; Female; Follow-Up Studies; Humans; Incidence; Infant; Ma | 1993 |
Childhood anemia in Africa: to transfuse or not transfuse?
Topics: Anemia; Blood Transfusion; Child, Preschool; Chloroquine; Hematocrit; HIV Infections; Hookworm Infec | 1993 |
Marital status and history of a previous child are risk factors in infant mortality.
Topics: Chloroquine; Double-Blind Method; Female; Humans; Infant Mortality; Infant, Newborn; Longitudinal St | 1994 |
Malaria chemosuppression in pregnancy. V. Placenta malarial changes among three different prophylaxis groups.
Topics: Chloroquine; Drug Therapy, Combination; Female; Humans; Malaria; Placenta Diseases; Pregnancy; Pregn | 1993 |
Malaria chemosuppression during pregnancy. IV. Its effects on the newborn's passive malaria immunity.
Topics: Animals; Antibodies, Protozoan; Cesarean Section; Chloroquine; Drug Therapy, Combination; Enzyme-Lin | 1993 |
Malaria chemosuppression in pregnancy. III. Its effects on the maternal malaria immunity.
Topics: Analysis of Variance; Animals; Antibodies, Protozoan; Chloroquine; Drug Therapy, Combination; Enzyme | 1993 |
Malaria chemoprophylaxis compliance in pregnant women: a cost-effectiveness analysis of alternative interventions.
Topics: Anthropology, Cultural; Antimalarials; Chloroquine; Cost-Benefit Analysis; Female; Health Education; | 1993 |
Malaria chemosuppression in pregnancy. II. Its effect on maternal haemoglobin levels, placental malaria and birth weight.
Topics: Anemia; Birth Weight; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Hemoglobins; | 1993 |
Increase of birth weight following chloroquine chemoprophylaxis during the first pregnancy: results of a randomized trial in Cameroon.
Topics: Adolescent; Adult; Animals; Antimalarials; Birth Weight; Cameroon; Chloroquine; Drug Resistance; Ery | 1995 |
Effect of training on the clinical management of malaria by medical assistants in Ghana.
Topics: Adult; Antimalarials; Case-Control Studies; Child; Child, Preschool; Chloroquine; Developing Countri | 1996 |
Lymphocyte proliferative response and subset profiles during extended periods of chloroquine or primaquine prophylaxis.
Topics: Adult; Antimalarials; Chloroquine; Cross-Sectional Studies; Humans; Indonesia; Lymphocyte Activation | 1996 |
Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine.
Topics: Adult; Animals; Antimalarials; Area Under Curve; Chloroquine; Double-Blind Method; Drug Therapy, Com | 1997 |
Lymphocyte response to tetanus toxoid among Indonesian men immunized with tetanus-diphtheria during extended chloroquine or primaquine prophylaxis.
Topics: Adult; Antimalarials; Chloroquine; Diphtheria Toxoid; Diphtheria-Tetanus Vaccine; Humans; Immune Tol | 1997 |
[Malaria chemoprophylaxis: tolerance and compliance with mefloquine and proguanil/chloroquine combination in French tourists].
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Female; France; Humans; Kenya; Malaria; Male; | 1997 |
The differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector.
Topics: Animals; Anopheles; Antimalarials; Carrier State; Chloroquine; Drug Combinations; Drug Resistance; F | 1998 |
Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis.
Topics: Adult; Antibodies, Bacterial; Antibody Formation; Antimalarials; Chloroquine; Diphtheria Toxoid; Dip | 1998 |
Intestinal parasite infections after extended use of chloroquine or primaquine for malaria prevention.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Feces; Humans; Indonesia; Intestinal Diseases, Parasi | 1998 |
Lymphocyte response to tetanus toxin T-cell epitopes: effects of tetanus vaccination and concurrent malaria prophylaxis.
Topics: Adult; Amino Acid Sequence; Antimalarials; Chloroquine; Epitopes, T-Lymphocyte; Humans; Lymphocyte A | 1999 |
Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in nonimmune Colombian soldiers.
Topics: Antimalarials; Chloroquine; Colombia; Double-Blind Method; Humans; Malaria; Malaria, Falciparum; Mal | 1999 |
A community perspective on the efficacy of malaria treatment options for children in Lundazi district, Zambia.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Services; Drug Combinations; F | 1999 |
Concentrations of chloroquine and malaria parasites in blood in Nigerian children.
Topics: Age Factors; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; M | 2000 |
Randomised trial of alternative malaria chemoprophylaxis strategies among pregnant women in Kigoma, Tanzania: I. Rationale and design.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Drug Administration Schedule; Drug Therapy, Combinati | 2000 |
Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria.
Topics: Administration, Rectal; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquin | 2001 |
Chloroquine prophylaxis, iron/folic-acid supplementation or case management of malaria attacks in primigravidae in western Uganda: effects on congenital malaria and infant haemoglobin concentrations.
Topics: Analysis of Variance; Anemia, Neonatal; Antimalarials; Birth Weight; Chloroquine; Double-Blind Metho | 2000 |
Improving adherence to malaria treatment for children: the use of pre-packed chloroquine tablets vs. chloroquine syrup.
Topics: Antimalarials; Caregivers; Child, Preschool; Chloroquine; Counseling; Drug Administration Schedule; | 2001 |
The impact of insecticide-treated bednets on malaria and anaemia in pregnancy in Kassena-Nankana district, Ghana: a randomized controlled trial.
Topics: Analysis of Variance; Anemia; Bedding and Linens; Birth Weight; Chloroquine; Cluster Analysis; Endem | 2001 |
[Value of malaria prophylaxis in surgical intervention in a malaria endemic zone , Niamey, Niger].
Topics: Antimalarials; Chloroquine; Drug Resistance; Endemic Diseases; Female; Humans; Malaria; Male; Niger; | 2001 |
Anemia of persistent malarial parasitemia in Nigerian children.
Topics: Anemia; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Hu | 2001 |
Chloroquine-resistant malaria in Burma.
Topics: Chloroquine; Clinical Trials as Topic; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Myanmar | 1975 |
A comparative study on the use of intramuscular chloroquine and quinine (as Quinimax) in the treatment of uncomplicated falciparum malaria in adults.
Topics: Adult; Chloroquine; Female; Humans; Injections, Intramuscular; Malaria; Male; Quinine | 1979 |
Suppression of malaria with monthly administration of combined sulphadoxine and pyrimethamine.
Topics: Adolescent; Adult; Blood; Child; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug Combi | 1975 |
Amodiaquine resistant falciparum malaria in Thailand.
Topics: Administration, Oral; Adolescent; Adult; Aminoquinolines; Amodiaquine; Chloroquine; Chromatography; | 1975 |
Malaria prophylaxis.
Topics: Chloroquine; Dapsone; Drug Combinations; Humans; Malaria; Military Medicine; Plasmodium falciparum; | 1975 |
Mefloquine (WR 142,490) in the treatment of human malaria.
Topics: Antimalarials; Chloroquine; Clinical Trials as Topic; Drug Resistance; Humans; Malaria; Mutation; Pi | 1975 |
Effect of chloroquine chemoprophylaxis during pregnancy on birth weight: results of a randomized trial.
Topics: Adult; Birth Weight; Burkina Faso; Chloroquine; Female; Humans; Malaria; Placenta Diseases; Pregnanc | 1992 |
Efficacy of quinine for falciparum malaria according to previous chloroquine exposure.
Topics: Animals; Child; Child, Preschool; Chloroquine; Coma; Drug Evaluation; Drug Resistance; Female; Human | 1991 |
Halofantrine-induced pruritus amongst subjects who itch to chloroquine.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Chloroquine; Drug Eruptions; Drug Hypersensitivity; | 1991 |
Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria.
Topics: Animals; Chloroquine; Deferoxamine; Drug Therapy, Combination; Humans; Malaria; Parasite Egg Count; | 1991 |
Comparison of mefloquine, chloroquine plus pyrimethamine-sulfadoxine (Fansidar), and chloroquine as malarial prophylaxis in eastern Thailand.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Animals; Antimalarials; Cambodia; Chloroquine; Confid | 1991 |
Antimalarial prophylaxis in pregnant Nigerian women.
Topics: Animals; Chloroquine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Malaria; Niger | 1990 |
Field study of cyproheptadine/chloroquine synergism in falciparum malaria.
Topics: Adolescent; Animals; Child; Chloroquine; Cyproheptadine; Drug Resistance; Drug Synergism; Drug Thera | 1990 |
Long-term chloroquine-proguanil malaria prophylaxis in a nonimmune pediatric population.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; H | 1991 |
The effect of chloroquine prophylaxis on yellow fever vaccine antibody response: comparison of plaque reduction neutralization test and enzyme-linked immunosorbent assay.
Topics: Administration, Oral; Adult; Animals; Antibodies, Viral; Chloroquine; Enzyme-Linked Immunosorbent As | 1991 |
Prolonged malaria prophylaxis with chloroquine and proguanil (chloroguanide) in a nonimmune resident population of an endemic area with a high prevalence of chloroquine resistance.
Topics: Adult; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Middle Aged; Proguanil | 1991 |
Efficacy of a loading dose of oral chloroquine in a 36-hour treatment schedule for uncomplicated plasmodium falciparum malaria.
Topics: Administration, Oral; Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Adminis | 1991 |
The efficacy of piriton on chloroquine-induced pruritus in patients with malaria.
Topics: Chloroquine; Chlorpheniramine; Female; Humans; Malaria; Male; Pruritus | 1991 |
[Comparison of 2 field methods for urinary assay of chloroquine].
Topics: Azo Compounds; Bromthymol Blue; Chloroquine; Female; Humans; Indicators and Reagents; Malaria; Pregn | 1991 |
The effect of short-term malaria chemoprophylaxis on the immune response of semi-immune adult volunteers.
Topics: Adult; Animals; B-Lymphocytes; Chloroquine; Complement System Proteins; Female; Fluorescent Antibody | 1990 |
Comparison of chloroquine, pyrimethamine and sulfadoxine, and chlorproguanil and dapsone as treatment for falciparum malaria in pregnant and non-pregnant women, Kakamega District, Kenya.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Dapsone; Drug Therapy, Combination; Female; | 1990 |
[Comparative study of sulfadoxine-pyrimethamine and amodiaquine + sulfadoxine-pyrimethamine for the treatment of malaria caused by chloroquine-resistant Plasmodium falciparum in Maputo, Mozambique].
Topics: Adult; Amodiaquine; Animals; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combinat | 1990 |
Lack of efficacy of pyrimethamine prophylaxis in pregnant Nigerian women.
Topics: Adolescent; Adult; Animals; Chloroquine; Drug Evaluation; Drug Resistance; Female; Follow-Up Studies | 1989 |
Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria.
Topics: Administration, Oral; Animals; Child; Child, Preschool; Chloroquine; Female; Gambia; Humans; Infant; | 1989 |
Intramuscular delagil therapy in malaria.
Topics: Administration, Oral; Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Female; Humans; I | 1989 |
Sensitivity of Plasmodium falciparum to chloroquine, amodiaquine and mefloquine in Ibadan, Nigeria.
Topics: Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; In Vitr | 1988 |
Comparison of the susceptibility of falciparum malaria to mefloquine-sulphadoxine-pyrimethamine and chloroquine in Nigeria.
Topics: Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Drug Administration Schedule; | 1988 |
Trials of mefloquine in vivax and of mefloquine plus 'fansidar' in falciparum malaria.
Topics: Adolescent; Adult; Chloroquine; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Dr | 1985 |
Decline in sensitivity of Plasmodium falciparum to chloroquine in The Gambia.
Topics: Child; Chloroquine; Gambia; Humans; Malaria; Microbial Sensitivity Tests; Plasmodium falciparum | 1987 |
Doxycycline prophylaxis for falciparum malaria.
Topics: Adolescent; Child; Chloroquine; Clinical Trials as Topic; Doxycycline; Humans; Malaria; Plasmodium f | 1987 |
Doxycycline prophylaxis for falciparum malaria.
Topics: Adolescent; Child; Chloroquine; Clinical Trials as Topic; Doxycycline; Humans; Malaria; Plasmodium f | 1987 |
Doxycycline prophylaxis for falciparum malaria.
Topics: Adolescent; Child; Chloroquine; Clinical Trials as Topic; Doxycycline; Humans; Malaria; Plasmodium f | 1987 |
Doxycycline prophylaxis for falciparum malaria.
Topics: Adolescent; Child; Chloroquine; Clinical Trials as Topic; Doxycycline; Humans; Malaria; Plasmodium f | 1987 |
Comparison of two strategies for control of malaria within a primary health care programme in the Gambia.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Workers; Dapsone; Drug Combina | 1988 |
Comparison of two strategies for control of malaria within a primary health care programme in the Gambia.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Workers; Dapsone; Drug Combina | 1988 |
Comparison of two strategies for control of malaria within a primary health care programme in the Gambia.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Workers; Dapsone; Drug Combina | 1988 |
Comparison of two strategies for control of malaria within a primary health care programme in the Gambia.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Workers; Dapsone; Drug Combina | 1988 |
Efficacy of multiple-dose halofantrine in treatment of chloroquine-resistant falciparum malaria in children in Kenya.
Topics: Administration, Oral; Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Clin | 1988 |
Clinical trials with halofantrine hydrochloride in Malawi.
Topics: Administration, Oral; Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Clin | 1988 |
Tolerability of long-term malaria prophylaxis with the combination mefloquine + sulfadoxine + pyrimethamine (Fansimef): results of a double blind field trial versus chloroquine in Nigeria.
Topics: Adolescent; Adult; Animals; Antimalarials; Aspartate Aminotransferases; Blood Cell Count; Child; Chl | 1988 |
Effectiveness of amodiaquine, sulfadoxine-pyrimethamine, and combinations of these drugs for treating chloroquine-resistant falciparum malaria in Hainan Island, China.
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, | 1988 |
Chloroquine and quinine: a randomized, double-blind comparison of efficacy and side effects in the treatment of Plasmodium falciparum malaria in the Philippines.
Topics: Adolescent; Adult; Animals; Chloroquine; Clinical Trials as Topic; Double-Blind Method; Humans; Mala | 1988 |
Evaluation of the sensitivity in vivo and in vitro of Plasmodium falciparum malaria to quinine in an area of full sensitivity to chloroquine.
Topics: Animals; Child; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug Resistance; Female; Hu | 1988 |
Studies on malaria prophylaxis with chlorproguanil or chloroquine in Mozambique.
Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Humans; Malaria; M | 1988 |
Sensitivity of Plasmodium falciparum to mefloquine-sulphadoxine-pyrimethamine (Fansimef) in vivo and to mefloquine alone in vitro in Nigeria.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Evaluation; Drug Resistance; Fem | 1988 |
[Efficacy of amodiaquine, Fansidar and their combination in the treatment of chloroquine-resistant falciparum malaria].
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Chloroquine; Double-Blind Method; Drug Combi | 1988 |
Efficacy of chemoprophylaxis in preventing Plasmodium falciparum parasitaemia and placental infection in pregnant women in Malawi.
Topics: Amodiaquine; Animals; Chloroquine; Female; Humans; Malaria; Malawi; Placenta Diseases; Plasmodium fa | 1988 |
[In vivo resistance of Plasmodium falciparum to 4-aminoquinolines and to a sulfadoxine-pyrimethamine combination. II. Study of Manaus, Amazonas 1983-1984].
Topics: Adolescent; Adult; Amodiaquine; Animals; Brazil; Chloroquine; Clinical Trials as Topic; Drug Resista | 1986 |
Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria; Ma | 1988 |
Malaria prophylaxis with proguanil in children living in a malaria-endemic area.
Topics: Animals; Child; Child, Preschool; Chloroquine; Humans; Malaria; Plasmodium falciparum; Plasmodium vi | 1988 |
Parasitologic and clinical efficacy of 25 and 50 mg/kg of chloroquine for treatment of Plasmodium falciparum malaria in Rwandan children.
Topics: Animals; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Infant; Malaria; Male; Mefl | 1988 |
Amodiaquine and sulfadoxine-pyrimethamine as treatment for chloroquine-resistant Plasmodium falciparum in Rwanda.
Topics: Amodiaquine; Animals; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Hum | 1988 |
Evaluation of four therapeutic regimens for falciparum malaria in Mozambique, 1986.
Topics: Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Drug Therapy, Combination; | 1988 |
A phase-III clinical trial of mefloquine in children with chloroquine-resistant falciparum malaria in Thailand.
Topics: Child; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Female; | 1987 |
Slow-release quinidine in the treatment of chloroquine resistant falciparum malaria: a double-blind trial.
Topics: Adolescent; Adult; Animals; Chloroquine; Clinical Trials as Topic; Delayed-Action Preparations; Doub | 1987 |
Double-blind study to assess the efficacy of chlorproguanil given alone or in combination with chloroquine for malaria chemoprophylaxis in an area with Plasmodium falciparum resistance to chloroquine, pyrimethamine and cycloguanil.
Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Double-Blind Metho | 1987 |
[Combined use of pyronaridine, sulfadoxine and primaquine in areas with chloroquine-resistant falciparum malaria].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Na | 1987 |
Effects of chloroquine, amodiaquine and pyrimethamine-sulfadoxine on Plasmodium falciparum gametocytemia.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinatio | 1986 |
Divided dose intramuscular regimen and single dose subcutaneous regimen for chloroquine: plasma concentrations and toxicity in patients with malaria.
Topics: Adolescent; Adult; Chloroquine; Female; Humans; Injections, Intramuscular; Injections, Subcutaneous; | 1986 |
The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria.
Topics: Adolescent; Anemia; Bone Marrow; Chloroquine; Clinical Trials as Topic; Double-Blind Method; Erythro | 1986 |
Monthly antimalarial chemotherapy to children in a holoendemic area of Liberia.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Hematocrit; Humans; Immunoglobulin G; Liberia; | 1986 |
Parenteral chloroquine for treating falciparum malaria.
Topics: Administration, Oral; Adolescent; Adult; Brain Diseases; Chloroquine; Female; Humans; Infusions, Int | 1987 |
Amodiaquine less effective than chloroquine in the treatment of falciparum malaria in the Philippines.
Topics: Adolescent; Adult; Amodiaquine; Biological Availability; Chloroquine; Clinical Trials as Topic; Drug | 1987 |
Malaria chemoprophylaxis with chloroquine in young Nigerian children. II. Effect on the immune response to vaccination.
Topics: Antibody Formation; BCG Vaccine; Child, Preschool; Chloroquine; Diphtheria; Humans; Immunity, Cellul | 1985 |
Malaria chemoprophylaxis with chloroquine in young Nigerian children. IV. Its effect on haematological measurements.
Topics: Child, Preschool; Chloroquine; Erythrocyte Count; Erythrocyte Indices; Erythrocytes; Ferritins; Foli | 1985 |
A clinical trial of mefloquine in the treatment of Plasmodium vivax malaria.
Topics: Adult; Chloroquine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Malaria; Mefloquine | 1985 |
The problem of drug resistance in malaria.
Topics: Africa; Animals; Antimalarials; Artemisinins; Chemical Phenomena; Chemistry; Chloroquine; Clinical T | 1985 |
In vivo and in vitro susceptibility to chloroquine of Plasmodium falciparum in Kinshasa and Mbuji-Mayi, Zaire.
Topics: Adolescent; Animals; Child; Chloroquine; Democratic Republic of the Congo; Drug Resistance, Microbia | 1985 |
Malaria chemoprophylaxis with chloroquine in young Nigerian children. I. Its effect on mortality, morbidity and the prevalence of malaria.
Topics: Antibodies; Child, Preschool; Chloroquine; Female; Humans; Immunoglobulin G; Immunoglobulin M; Infan | 1985 |
A comparative clinical study of mefloquine and chloroquine in the treatment of vivax malaria.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Female; Humans; Malaria; Male; Mefloquine; Middle Age | 1985 |
Malaria chemoprophylaxis with chloroquine in young Nigerian children. III. Its effect on nutrition.
Topics: Anthropometry; Body Height; Body Weight; Child, Preschool; Chloroquine; Humans; Infant; Infant Nutri | 1985 |
Orally administered amodiaquine base suspensions in the treatment of acute malaria infections of young children in Nigeria.
Topics: Administration, Oral; Amodiaquine; Blood; Child; Child, Preschool; Chloroquine; Dose-Response Relati | 1974 |
Tetracycline treatment of chloroquine-resistant falciparum malaria in Thailand.
Topics: Administration, Oral; Chloroquine; Drug Resistance, Microbial; Drug Synergism; Humans; Malaria; Plas | 1972 |
Suppressive and curative trials in Plasmodium malariae infection with Fansidar.
Topics: Child; Chloroquine; Clinical Trials as Topic; Drug Combinations; Humans; Malaria; Nephrosis; Plasmod | 1972 |
Letter: Falciparum malaria resistant to chloroquine suppression but sensitive to chloroquine treatment in West Malaysia.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Infant; Malaria; Malaysia; Placebos; Plasmodium fal | 1973 |
Combined chloroquine-primaquine therapy against vivax malaria.
Topics: Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; Malaria; Plasmodium vivax | 1974 |
Sensitivity of four Central American strains of Plasmodium vivax to primaquine.
Topics: Animals; Central America; Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; | 1974 |
Sulfalene with pyrimethamine and chloroquine with pyrimethamine in single-dose treatment of Plasmodium falciparum infections. A trial in a rural population in northern Nigeria.
Topics: Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Humans; Infant; Malar | 1973 |
Combinations of 4-aminobenzoic acid competitors and dihydrofolate dehydrogenase inhibitors in the chemotherapy of malaria. A commentary.
Topics: Africa; Antimalarials; Asia; Chloroquine; Clinical Trials as Topic; Dapsone; Drug Evaluation; Drug R | 1974 |
[New trends in malaria therapy with folic acid antagonists].
Topics: Chloroquine; Clinical Trials as Topic; Folic Acid Antagonists; Humans; Malaria; Nigeria; Pyrimethami | 1968 |
The drug response of a normal and a multi-resistant strain of P. falciparum to sulphalene.
Topics: Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Synergism; Folic Acid Antago | 1968 |
[Clinical studies on chloroquine-resistant Plasmodium falciparum].
Topics: Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; Mal | 1968 |
Reduction of reaction due to iron dextran infusion using chloroquine.
Topics: Anemia; Chloroquine; Female; Humans; Iron-Dextran Complex; Malaria; Plasmodium falciparum; Pregnancy | 1970 |
Studies on the antimalarial property of 4-methoxy-6-sulfanilamido-pyrimidine monohydrate (sulfamonomethoxine: DJ-1550) and on its effect on the chloroquine-resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Depression, Chemical; Erythrocytes; Humans; Malaria; Mice; Plas | 1970 |
Supplemental folates in the therapy of Plasmodium falciparum malaria.
Topics: Administration, Oral; Anemia; Antimalarials; Blood Platelets; Chloroquine; Clinical Trials as Topic; | 1970 |
Prophylactic and sporontocidal treatment of chloroquine resistant Plasmodium falciparum from Malaya.
Topics: Adult; Amodiaquine; Anopheles; Antimalarials; Blood; Chloroquine; Clinical Trials as Topic; Dapsone; | 1970 |
Trimethoprim plus sulphamethoxazole compared with chloroquine in the treatment and suppression of malaria in African schoolchildren.
Topics: Africa; Child; Child, Preschool; Chloroquine; Drug Synergism; Female; Folic Acid Antagonists; Humans | 1971 |
Characterization of a drug resistant strain of Plasmodium falciparum from the Philippines.
Topics: Adult; Anopheles; Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; Malaria | 1971 |
Prophylactic and sporontocidal treatment of chloroquine-resistant Plasmodium falciparum from Vietnam.
Topics: Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Dapsone; Humans; Malaria; Male; Methemo | 1971 |
Treatment of Plasmodium falciparum malaria in Cameroon with a single dose of antifolic drugs. 1. Combination of sulfametopyrazine and pyrimethamine.
Topics: Adolescent; Adult; Aged; Cameroon; Child; Child, Preschool; Chloroquine; Clinical Trials as Topic; D | 1971 |
Treatment of Plasmodium falciparum malaria in Cameroon with a single dose of antifolic drugs. 2. Combination of sulfametopyrazine and trimethoprim.
Topics: Adolescent; Adult; Anti-Infective Agents; Cameroon; Child; Child, Preschool; Chloroquine; Clinical T | 1971 |
Characteristics of four new drug-resistant strains of Plasmodium falciparum from South-East Asia.
Topics: Adult; Antimalarials; Asia, Southeastern; Chloroquine; Clinical Trials as Topic; Drug Resistance, Mi | 1969 |
Diformyl diaminodiphenyl sufone (DFD) as an antimalarial in man.
Topics: Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Dapsone; Formates; Humans; Malaria; Mal | 1970 |
The role of malaria, folic acid deficiency and haemoglobin AS in pregnancy at Mulago hospital.
Topics: Adolescent; Adult; Anemia; Anemia, Hypochromic; Birth Weight; Blood Volume Determination; Chloroquin | 1972 |
Antibody production in Plasmodium vivax infections suppressed by weekly doses of chloroquine.
Topics: Adult; Antibody Formation; Chloroquine; Clinical Trials as Topic; Fluorescent Antibody Technique; Hu | 1965 |
Studies on chloroquine-resistance of Plasmodium falciparum in Upper Volta and Liberia, West Africa.
Topics: Adolescent; Burkina Faso; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; | 1966 |
Field trial of cycloguanil pamoate in the treatment and suppression of malaria in Nigerian school children: a preliminary report.
Topics: Adult; Antimalarials; Blood; Child; Chloroquine; Delayed-Action Preparations; Humans; Injections, In | 1970 |
An apparent decline in the efficacy of small doses of chloroquine in suppressing malaria parasitaemias in semi-immune African schoolchildren.
Topics: Adolescent; Child; Chloroquine; Humans; Malaria; Tanzania | 1966 |
2537 other studies available for chloroquine and Malaria
| Article | Year |
|---|---|
Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity.
Topics: Animals; Antimalarials; Bacteria; Chemical Phenomena; Chemistry; Chickens; Drug Resistance; Folic Ac | 1979 |
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
Topics: Animals; Antimalarials; Bacteria; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Folic Ac | 1977 |
Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Cyclohexylamines; Drug Resistance; Malaria; Molecular Conformat | 1992 |
Antimalarial activity of new water-soluble dihydroartemisinin derivatives. 2. Stereospecificity of the ether side chain.
Topics: Animals; Artemisinins; Chemical Phenomena; Chemistry; Malaria; Mice; Molecular Structure; Plasmodium | 1989 |
Arteether, a new antimalarial drug: synthesis and antimalarial properties.
Topics: Animals; Antimalarials; Artemisinins; Magnetic Resonance Spectroscopy; Malaria; Mice; Models, Molecu | 1988 |
Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.
Topics: Animals; Antimalarials; Chloroquine; Female; Ferrous Compounds; Malaria; Metallocenes; Mice; Plasmod | 1997 |
Novel quinone methides from Salacia kraussii with in vitro antimalarial activity.
Topics: Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Carbohydrate Sequence; Chromatography, Hi | 1998 |
Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines.
Topics: Animals; Antimalarials; Biopolymers; Hemin; Malaria; Male; Mice; Plasmodium berghei; Plasmodium falc | 1998 |
New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain.
Topics: Aniline Compounds; Animals; Antimalarials; Inhibitory Concentration 50; Malaria; Male; Mannich Bases | 1999 |
New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite.
Topics: Animals; Antimalarials; Drugs, Chinese Herbal; Malaria; Male; Mice; Mice, Inbred ICR; Models, Molecu | 1999 |
Phenyl beta-methoxyacrylates: a new antimalarial pharmacophore.
Topics: Acrylates; Administration, Cutaneous; Administration, Oral; Animals; Antimalarials; Benzene Derivati | 2000 |
Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines.
Topics: Aniline Compounds; Animals; Antimalarials; Cells, Cultured; Drug Resistance; Female; Humans; Macroph | 2001 |
Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials.
Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Guanidines; Ma | 2001 |
A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.
Topics: Aniline Compounds; Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance; Enzyme Inhibitor | 2001 |
Antimalarial alkoxylated and hydroxylated chalcones [corrected]: structure-activity relationship analysis.
Topics: Animals; Anisoles; Antimalarials; Chalcone; Chromatography, High Pressure Liquid; Hydrophobic and Hy | 2001 |
New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antimalarials; Enzyme Inhibitors; Hydrolases; Malaria; M | 2002 |
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.
Topics: Animals; Antimalarials; Artemisinins; Heterocyclic Compounds, 4 or More Rings; Malaria; Male; Mice; | 2002 |
Potent antimalarial febrifugine analogues against the plasmodium malaria parasite.
Topics: Animals; Antimalarials; Cell Line; Malaria; Mice; Piperidines; Plasmodium berghei; Plasmodium falcip | 2002 |
Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents.
Topics: Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance; Humans; Inhibitory Concentration 50 | 2002 |
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Drug Evaluation, Preclinical; Drug Resis | 2002 |
Synthesis, stability, and antimalarial activity of new hydrolytically stable and water-soluble (+)-deoxoartelinic acid.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Heterocyclic Compounds, 3-Ring; Hydrolysis; Ma | 2002 |
Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine.
Topics: Animals; Antimalarials; Culicidae; Germ Cells; Malaria; Mice; Oocysts; Oxidation-Reduction; Plasmodi | 2002 |
Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.
Topics: Animals; Antimalarials; Antineoplastic Agents; Chloroquine; Drug Resistance; Female; Humans; Malaria | 2003 |
New semisynthetic quassinoids with in vivo antimalarial activity.
Topics: Animals; Antimalarials; Drug Stability; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Qu | 2003 |
A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.
Topics: Animals; Antimalarials; Bridged Bicyclo Compounds, Heterocyclic; Malaria; Male; Mice; Mice, Inbred I | 2003 |
Geraniol-derived 1,2,4-trioxanes with potent in-vivo antimalarial activity.
Topics: Acyclic Monoterpenes; Animals; Antimalarials; Malaria; Mice; Plasmodium yoelii; Terpenes | 2003 |
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Crystallography, X-Ray; Malaria; Male; Plasmod | 2003 |
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Cell Line; Cricetinae; Diphosphonates; Entamoeba histo | 2004 |
Orally active amino functionalized antimalarial 1,2,4-trioxanes.
Topics: Administration, Oral; Animals; Antimalarials; Drug Resistance, Multiple; Malaria; Mice; Plasmodium y | 2004 |
Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity.
Topics: Animals; Antimalarials; Malaria; Methemoglobin; Mice; Plasmodium berghei; Plasmodium falciparum; Pla | 2004 |
Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Malaria; Mice; Naphthoquinones; Phenazines | 2004 |
Mono- and bis-thiazolium salts have potent antimalarial activity.
Topics: Animals; Antimalarials; Female; Malaria; Mice; Plasmodium falciparum; Structure-Activity Relationshi | 2005 |
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.
Topics: Animals; Antimalarials; Chalcones; Cysteine Endopeptidases; Globins; Heme; Hemeproteins; Hydrolysis; | 2005 |
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Topics: Alkyl and Aryl Transferases; Animals; Antimalarials; Cells, Cultured; Electrophoresis, Polyacrylamid | 2005 |
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Topics: Adamantane; Animals; Antimalarials; Cell Line, Tumor; Drug Resistance; Half-Life; Malaria; Malaria, | 2005 |
Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: design, construction, characterization, and pharmacology of metaquine.
Topics: Aminoquinolines; Animals; Antimalarials; Databases, Factual; Drug Design; Heme; Hemin; Malaria; Mass | 2005 |
Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives.
Topics: Administration, Oral; Animals; Antimalarials; Carbamates; Guanidines; Imidazoles; Imidazolidines; Ma | 2005 |
Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Parasitic Se | 2006 |
8-(1-Naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro (4.5) decane, a new 1,2,4-trioxane effective against rodent and simian malaria.
Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Haplorhini; Het | 2006 |
Orally active 1,2,4-trioxanes: synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant plasmodium yoelii nigeriensis in mice.
Topics: Administration, Oral; Amination; Animals; Antimalarials; Artemisinins; Drug Resistance, Multiple; He | 2006 |
Exploration of a new type of antimalarial compounds based on febrifugine.
Topics: Animals; Antimalarials; Cell Line; Malaria; Mice; Parasitic Sensitivity Tests; Piperidines; Plasmodi | 2006 |
Synthesis and antimalarial efficacy of aza-fused rhodacyanines in vitro and in the P. berghei mouse model.
Topics: Animals; Antimalarials; Aza Compounds; Cell Line; Drug Resistance; Malaria; Mice; Plasmodium berghei | 2006 |
A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Dibenzazepines; Drug Resistance; Female; Malaria; Mice; Plasmod | 2006 |
Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives.
Topics: Administration, Oral; Alkanes; Amidines; Animals; Antimalarials; Female; Humans; Hydroxylation; Indi | 2007 |
Synthesis and antimalarial evaluation of a series of piperazinyl flavones.
Topics: Animals; Antimalarials; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Resistance; Drug Screenin | 2007 |
Synthesis and antimalarial activity of new isotebuquine analogues.
Topics: Animals; Antimalarials; Biphenyl Compounds; Drug Resistance; Magnetic Resonance Spectroscopy; Malari | 2007 |
Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Malaria; Mal | 2007 |
Antimalarial activity of 1-aryl-3,3-dialkyltriazenes.
Topics: Animals; Antimalarials; Erythrocytes; Female; Indicators and Reagents; Injections, Intraperitoneal; | 2007 |
Synthesis and antimalarial property of orally active phenoxazinium salts.
Topics: Administration, Oral; Animals; Antimalarials; Drug Resistance; Lethal Dose 50; Malaria; Mice; Oxazin | 2007 |
Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1).
Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Cyclohexane | 2007 |
Synthesis and evaluation of naphthyridine compounds as antimalarial agents.
Topics: Animals; Antimalarials; Disease Models, Animal; Inhibitory Concentration 50; Malaria; Molecular Stru | 2007 |
Synthesis and antimalarial activity of semicarbazone and thiosemicarbazone derivatives.
Topics: Animals; Cell Proliferation; Humans; Lymphocytes; Malaria; Mice; Plasmodium falciparum; Semicarbazon | 2008 |
Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline.
Topics: Amides; Animals; Antimalarials; Carbamates; Cell Line; Female; Humans; Malaria; Mice; Plasmodium fal | 2008 |
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.
Topics: Animals; Antimalarials; Cell Line; DNA; Female; Guanidines; Hemeproteins; Hemin; Imidazolines; Malar | 2008 |
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.
Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug T | 2008 |
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents.
Topics: Acridines; Animals; Antimalarials; Chloroquine; Drug Design; Drug Resistance; Hemeproteins; Humans; | 2008 |
Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.
Topics: Animals; Antiprotozoal Agents; Aza Compounds; Humans; Kidney; Macrocyclic Compounds; Malaria; Models | 2008 |
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
Topics: Animals; Antimalarials; Malaria; Mice; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodiu | 2008 |
Synergy of human immunodeficiency virus protease inhibitors with chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo.
Topics: Animals; Antimalarials; Atazanavir Sulfate; Chloroquine; Drug Resistance; Drug Synergism; Female; HI | 2008 |
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.
Topics: Adenine; Animals; Antimalarials; Cell Line; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; C | 2008 |
Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge.
Topics: Alkyl and Aryl Transferases; Animals; Antimalarials; Cell Cycle Proteins; Chloroquine; Dose-Response | 2008 |
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.
Topics: Animals; Antimalarials; Chemistry, Pharmaceutical; Cysteine Endopeptidases; Cysteine Proteinase Inhi | 2008 |
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug | 2008 |
Antimalarial activity of a new stilbene glycoside from Parthenocissus tricuspidata in mice.
Topics: Animals; Antimalarials; Chloroquine; Glycosides; Malaria; Male; Mice; Mice, Inbred ICR; Plant Extrac | 2008 |
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors.
Topics: Animals; Antimalarials; Aotidae; Drug Resistance; Enzyme Inhibitors; Histone Deacetylase Inhibitors; | 2008 |
New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton.
Topics: Aminoquinolines; Animals; Antimalarials; Binding Sites; Disease Models, Animal; Dose-Response Relati | 2008 |
Carbonic anhydrase inhibitors: inhibition of Plasmodium falciparum carbonic anhydrase with aromatic/heterocyclic sulfonamides-in vitro and in vivo studies.
Topics: Animals; Antimalarials; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chemistry, Pharmaceutica | 2008 |
Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Topics: Amines; Amino Acid Motifs; Animals; Antigens, Protozoan; Antimalarials; Antiprotozoal Agents; Chemis | 2008 |
Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities.
Topics: Animals; Antimalarials; Chalcone; Hemeproteins; Hemoglobins; Humans; Hydrolysis; Malaria; Mice; Plas | 2009 |
Search for new pharmacophores for antimalarial activity. Part II: synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines.
Topics: Animals; Antimalarials; Inhibitory Concentration 50; Malaria; Plasmodium falciparum; Plasmodium yoel | 2009 |
Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Cyclams; Hemeproteins; Heterocyclic Compounds; | 2009 |
Pharmacodynamics and pharmacokinetics studies of phenoxazinium derivatives for antimalarial agent.
Topics: Animals; Antimalarials; Female; Malaria; Male; Mice; Mice, Inbred ICR; Oxazines; Parasitic Sensitivi | 2009 |
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Benzylamines; Cytochrome P-450 Enzyme Inhibito | 2009 |
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Cell Survival; Chloroquine; Dogs; Drug Resista | 2009 |
Synthesis and biological evaluation of febrifugine analogues as potential antimalarial agents.
Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Hydrangeaceae; Malaria; Mice; Molecular Struct | 2009 |
Antimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae).
Topics: Animals; Antimalarials; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Humans; Magnetic Reso | 2009 |
Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.
Topics: Antimalarials; Antiprotozoal Agents; Histone Deacetylase Inhibitors; Histone Deacetylases; Leishmani | 2010 |
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Foli | 2010 |
Synthesis and evaluation of alpha-halogenated analogues of 3-(acetylhydroxyamino)propylphosphonic acid (FR900098) as antimalarials.
Topics: Acute Disease; Animals; Antimalarials; Fosfomycin; Malaria; Mice; Plasmodium berghei; Plasmodium fal | 2010 |
Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.
Topics: Animals; Antimalarials; Carbolines; Cell Line; Crystallography, X-Ray; Humans; In Vitro Techniques; | 2010 |
Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Heme; Hemeproteins; Lymphocytes; Malaria; Mice | 2010 |
Spiroindolones, a potent compound class for the treatment of malaria.
Topics: Adenosine Triphosphatases; Animals; Antimalarials; Cell Line; Drug Discovery; Drug Resistance; Eryth | 2010 |
In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Indonesia; M | 2011 |
4-anilinoquinoline triazines: a novel class of hybrid antimalarial agents.
Topics: Animals; Antimalarials; Cell Proliferation; Chlorocebus aethiops; Hemeproteins; Malaria; Mice; Model | 2011 |
A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.
Topics: Animals; Anopheles; Anti-Bacterial Agents; Antimalarials; Antiviral Agents; Botulinum Toxins, Type A | 2011 |
Potent antiprotozoal activity of a novel semi-synthetic berberine derivative.
Topics: Animals; Antiprotozoal Agents; Berberine; Chlorocebus aethiops; Disease Models, Animal; Inhibitory C | 2011 |
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Drug Design; Drug Disc | 2011 |
Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives.
Topics: Administration, Oral; Animals; Antimalarials; Guanidines; Imidazolidines; Imidazolines; Macaca mulat | 2011 |
Antimalarial pyrido[1,2-a]benzimidazoles.
Topics: Administration, Oral; Animals; Antimalarials; Benzimidazoles; Drug Resistance, Multiple; Humans; In | 2011 |
Imidazolopiperazines: hit to lead optimization of new antimalarial agents.
Topics: Amino Acids; Aniline Compounds; Animals; Antimalarials; Benzene Derivatives; Cell Line; Drug Resista | 2011 |
Antimalarial activity of natural and synthetic prodiginines.
Topics: Animals; Antimalarials; Cell Line; Cell Survival; Female; Malaria; Mice; Plasmodium falciparum; Plas | 2011 |
Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum.
Topics: Animals; Antimalarials; Cell Line; Cell Membrane Permeability; Dimerization; Dogs; Drug Resistance; | 2011 |
Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr).
Topics: Aldose-Ketose Isomerases; Animals; Antimalarials; Crystallography, X-Ray; Erythrocytes; Fosfomycin; | 2011 |
Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Drug Design; Inhibitory Concentration 50; Leishmania d | 2011 |
Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).
Topics: Animals; Antimalarials; Biological Transport; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cri | 2011 |
Antimalarial activity of physalins B, D, F, and G.
Topics: Animals; Antimalarials; Immunosuppressive Agents; Malaria; Mice; Mice, Inbred BALB C; Parasitemia; P | 2011 |
Novel orally active antimalarial thiazoles.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Cytochrome P-450 CYP1A2 Inhib | 2011 |
Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections.
Topics: Animals; Antimalarials; Cell Line; Cell Line, Tumor; Cell Survival; Erythrocytes; Humans; Liver; Mal | 2011 |
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resista | 2011 |
Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin.
Topics: Amides; Amines; Aminoquinolines; Animals; Antimalarials; Azithromycin; Cell Line, Tumor; Drug Resist | 2012 |
Febrifugine analogue compounds: synthesis and antimalarial evaluation.
Topics: Animals; Antimalarials; Aotus trivirgatus; Drug Evaluation, Preclinical; Malaria; Piperidines; Plasm | 2012 |
Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents.
Topics: Aminoquinolines; Antimalarials; Azithromycin; Cell Line; Chloroquine; Humans; Macrolides; Malaria; P | 2012 |
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Topics: Administration, Oral; Animals; Antimalarials; Atovaquone; Crystallography, X-Ray; Cytochromes b; Dru | 2012 |
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
Topics: Administration, Oral; Aminopyridines; Animals; Antimalarials; Biological Availability; Cell Line; Ch | 2012 |
Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores.
Topics: Administration, Oral; Animals; Antimalarials; Biphenyl Compounds; Cell Line; Chalcone; Chlorocebus a | 2012 |
Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.
Topics: Animals; Antimalarials; Disulfides; Malaria; Mice; Plasmodium falciparum; Prodrugs; Stereoisomerism; | 2012 |
Lead optimization of antimalarial propafenone analogues.
Topics: Administration, Oral; Animals; Antimalarials; Chloroquine; Cytochrome P-450 CYP2D6; Cytochrome P-450 | 2012 |
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
Topics: Aminoquinolines; Animals; Antimalarials; Biological Transport; Cell Line; Chloroquine; Clotrimazole; | 2012 |
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.
Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Antimalarials; Dose-Response Relations | 2012 |
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold.
Topics: Anthraquinones; Anti-Bacterial Agents; Antimalarials; Cortinarius; Drug Evaluation, Preclinical; Fib | 2012 |
Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.
Topics: Aminopeptidases; Animals; Antimalarials; Cell Line; Drug Resistance; Female; Humans; Malaria; Malona | 2012 |
Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds.
Topics: Acetamides; Animals; Antimalarials; Drug Discovery; Inhibitory Concentration 50; Malaria; Molecular | 2013 |
Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents.
Topics: Animals; Antimalarials; Benzopyrans; Catalytic Domain; Chalcones; Chromans; Crotalaria; Cysteine End | 2013 |
Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines.
Topics: Alkaloids; Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance; Indoles; Malaria; Mice; | 2013 |
Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria.
Topics: Antimalarials; Cell Line, Tumor; Humans; Imines; Liver; Malaria; Parasitic Sensitivity Tests; Plasmo | 2013 |
In vivo antimalarial activity of novel 2-hydroxy-3-anilino-1,4-naphthoquinones obtained by epoxide ring-opening reaction.
Topics: Animals; Antimalarials; Epoxy Compounds; Malaria; Mice; Molecular Structure; Naphthoquinones; Plasmo | 2013 |
Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora.
Topics: Antimalarials; Drugs, Chinese Herbal; Humans; Malaria; Picrorhiza; Plasmodium falciparum | 2013 |
3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.
Topics: Animals; Antimalarials; Drug Resistance; Hep G2 Cells; Humans; Liver; Malaria; Malaria, Falciparum; | 2013 |
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
Topics: Animals; Antimalarials; Biological Availability; Drug Design; Drug Resistance; Drug Stability; Gene | 2014 |
Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.
Topics: Animals; Antimalarials; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; | 2014 |
N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.
Topics: Aminopyridines; Animals; Antimalarials; Benzimidazoles; Hepatocytes; Humans; Malaria; Mice, SCID; Mi | 2014 |
2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes.
Topics: Animals; Antimalarials; Cell Line, Tumor; Dose-Response Relationship, Drug; Fatty Acid Synthase, Typ | 2014 |
Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay.
Topics: Animals; Antimalarials; Area Under Curve; Cell Line, Tumor; Cell Survival; Drug Discovery; Drug Eval | 2014 |
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
Topics: Animals; Antimalarials; Humans; Inhibitory Concentration 50; Malaria; Mice; Microsomes, Liver; Paras | 2014 |
Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds.
Topics: Animals; Antimalarials; Chloroquine; Malaria; Mice; Parasitemia; Parasitic Sensitivity Tests; Phenan | 2014 |
MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii.
Topics: Antimalarials; Betaine; Humans; Malaria; Molecular Structure; Nuclear Magnetic Resonance, Biomolecul | 2014 |
Synthesis of chiral chloroquine and its analogues as antimalarial agents.
Topics: Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Malaria; Mice; Plasmodiu | 2014 |
Pentacycloundecylamines and conjugates thereof as chemosensitizers and reversed chloroquine agents.
Topics: Amines; Antimalarials; Chloroquine; Humans; Malaria; Molecular Structure | 2014 |
Synthesis of novel triazole-linked mefloquine derivatives: biological evaluation against Plasmodium falciparum.
Topics: Antimalarials; Humans; Malaria; Mefloquine; Molecular Structure; Plasmodium falciparum; Structure-Ac | 2014 |
The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs.
Topics: Antimalarials; Humans; Malaria; Models, Molecular; Molecular Structure; Plasmodium falciparum; Quant | 2015 |
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Topics: Animals; Antimalarials; Cell Line, Tumor; Dipeptides; Disease Models, Animal; Histone Deacetylase In | 2015 |
Prodrugs of reverse fosmidomycin analogues.
Topics: Animals; Antimalarials; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Fos | 2015 |
Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives.
Topics: Animals; Antimalarials; Hep G2 Cells; Humans; Malaria; Malaria, Falciparum; Male; Mice; Naphthyridin | 2015 |
Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium.
Topics: Animals; Antimalarials; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Drug Discovery; Eryth | 2015 |
Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Chlorocebus aethiops; Disease Mo | 2015 |
New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
Topics: Animals; Antimalarials; Malaria; Mice; Molecular Structure; Plasmodium berghei; Plasmodium falciparu | 2015 |
Synthesis, β-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Hemeproteins; Ma | 2015 |
Anti-Plasmodium falciparum activity of quinoline-sulfonamide hybrids.
Topics: Animals; Humans; Malaria; Mice; Molecular Structure; Plasmodium falciparum; Quinolines; Sulfonamides | 2015 |
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
Topics: Aminoquinolines; Animals; Antimalarials; Benzene Derivatives; Humans; Malaria; Malaria, Falciparum; | 2015 |
Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.
Topics: Antimalarials; Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Indoles; Malar | 2015 |
In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
Topics: Antimalarials; Dose-Response Relationship, Drug; Malaria; Molecular Structure; Momordica; Parasitic | 2015 |
Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines.
Topics: Administration, Oral; Animals; Antimalarials; Crystallography, X-Ray; Drug Resistance; Ether-A-Go-Go | 2015 |
Synthesis, in vitro and in silico antimalarial activity of 7-chloroquinoline and 4H-chromene conjugates.
Topics: Animals; Antimalarials; Cell Survival; Chlorocebus aethiops; Chloroquine; Chromones; Computer Simula | 2015 |
Discovery and optimisation studies of antimalarial phenotypic hits.
Topics: Animals; Antimalarials; Cell Line; Cell Survival; Disease Models, Animal; Dose-Response Relationship | 2015 |
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.
Topics: Animals; Antimalarials; Ether-A-Go-Go Potassium Channels; Humans; Liver; Malaria; Malaria, Falciparu | 2015 |
Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.
Topics: Alkaloids; Animals; Annonaceae; Antimalarials; Chlorocebus aethiops; Dose-Response Relationship, Dru | 2016 |
Indolyl-3-ethanone-α-thioethers: A promising new class of non-toxic antimalarial agents.
Topics: Antimalarials; Dose-Response Relationship, Drug; HeLa Cells; Humans; Indoles; Malaria; Molecular Str | 2016 |
Novel nucleoside-based antimalarial compounds.
Topics: Animals; Antimalarials; Cell Line; Dose-Response Relationship, Drug; Humans; Malaria; Molecular Stru | 2016 |
Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.
Topics: Animals; Antimalarials; Humans; Malaria; Malaria, Falciparum; Mice, SCID; Parasitemia; Plasmodium be | 2016 |
Conjugation of N-acylhydrazone and 1,2,4-oxadiazole leads to the identification of active antimalarial agents.
Topics: Animals; Antimalarials; Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Hydra | 2016 |
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
Topics: Animals; Antimalarials; Disease Models, Animal; Dose-Response Relationship, Drug; Ether-A-Go-Go Pota | 2016 |
Docking, synthesis and antimalarial activity of novel 4-anilinoquinoline derivatives.
Topics: Aniline Compounds; Antimalarials; Cysteine Endopeptidases; Hemeproteins; Humans; Malaria; Molecular | 2017 |
Synthesis and evaluation of anti-plasmodial and cytotoxic activities of epoxyazadiradione derivatives.
Topics: Animals; Antimalarials; Antineoplastic Agents; Azadirachta; Cell Line, Tumor; Cell Proliferation; Hu | 2017 |
Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide.
Topics: Antimalarials; Dose-Response Relationship, Drug; Malaria; Molecular Docking Simulation; Molecular St | 2017 |
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.
Topics: Amides; Animals; Antimalarials; Boron Compounds; Dogs; Female; Humans; Malaria; Malaria, Falciparum; | 2017 |
3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally.
Topics: Amides; Animals; Antimalarials; Hep G2 Cells; Humans; Hydrazones; Malaria; Mice; Phenanthrenes; Plas | 2017 |
Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.
Topics: Animals; Antimalarials; Female; Ferrous Compounds; Heterocyclic Compounds, 1-Ring; Malaria; Mice; Pe | 2017 |
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
Topics: Antimalarials; Carbamates; Cathepsin L; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dip | 2017 |
4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice.
Topics: Administration, Oral; Aminopyridines; Aminoquinolines; Animals; Antimalarials; Cell Membrane Permeab | 2017 |
Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens.
Topics: Animals; Bacteria; Community-Acquired Infections; Cross Infection; Gram-Negative Bacteria; Gram-Posi | 2018 |
Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate.
Topics: Acrylates; Animals; Antimalarials; Antineoplastic Agents; Apoptosis; Cells, Cultured; Chloroquine; H | 2018 |
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ
Topics: Animals; Disease Models, Animal; Drug Discovery; Drug Stability; ERG1 Potassium Channel; Humans; Imi | 2018 |
Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies.
Topics: Animals; Antimalarials; Chloroquine; Female; Hep G2 Cells; Humans; Life Cycle Stages; Malaria; Mice, | 2018 |
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
Topics: Animals; Antimalarials; Benzimidazoles; Disease Models, Animal; Drug Design; ERG1 Potassium Channel; | 2019 |
New hybrid trifluoromethylquinolines as antiplasmodium agents.
Topics: Animals; Antimalarials; Cell Line; Drug Discovery; Erythrocytes; Halogenation; Haplorhini; Humans; M | 2019 |
Efficacy of TLR7 agonistic imidazoquinoline as immunochemotherapeutic agent against P. Berghei ANKA infected rodent host.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Imidazoles; Interferon-gamma; Interleuk | 2019 |
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
Topics: Acridones; Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Hep G2 Cells; Humans; Mal | 2019 |
4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Disease Models, Animal; Drug | 2019 |
Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity.
Topics: Animals; Antimalarials; Cell Line; Cell Survival; Disease Models, Animal; Drug Resistance; Malaria; | 2019 |
Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Benzimidazoles; Disease Models, Animal; Dose-Response | 2019 |
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
Topics: Acridones; Administration, Oral; Animals; Antimalarials; Cell Survival; Disease Models, Animal; Fema | 2020 |
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and
Topics: Animals; Antimalarials; Disease Models, Animal; Half-Life; Hemeproteins; Imidazoles; Life Cycle Stag | 2020 |
Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Cell Line; Cell Survival; Chloroquine; Drug Design | 2020 |
In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization.
Topics: Animals; Antimalarials; Cell Line; Erythrocytes; Female; Hemeproteins; Hemin; Hemolysis; Humans; Mal | 2021 |
Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1
Topics: Administration, Oral; Animals; Antimalarials; Cyclization; Disease Models, Animal; Ethers; Female; H | 2021 |
THC shows activity against cultured Plasmodium falciparum.
Topics: Antimalarials; Cannabis; Dose-Response Relationship, Drug; Dronabinol; Hemeproteins; HL-60 Cells; Hu | 2021 |
Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.
Topics: Amino Alcohols; Animals; Antimalarials; Cell Line; Cricetulus; Dose-Response Relationship, Drug; Dru | 2022 |
Comparative in vivo antimalarial activities of aqueous and methanol extracts of MAMA powder - A herbal antimalarial preparation.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Malaria; Mice; Phytotherapy; Plant Extracts; P | 2022 |
[The Follow-Up of Treatment Process of Malaria By Real-Time Polymerase Chain Reaction: In Vivo Model].
Topics: Animals; Chloroquine; Follow-Up Studies; Humans; Malaria; Male; Mice; Microscopy; Plasmodium berghei | 2021 |
Synthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Plasmodium berghei; Plasmodium falciparum | 2022 |
Frequency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malaria.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Brazil; Case-Control Studies; Chlor | 2022 |
Cryptic Plasmodium inui and Plasmodium fieldi Infections Among Symptomatic Malaria Patients in Thailand.
Topics: Animals; Artemisinins; Chloroquine; Electron Transport Complex IV; Humans; Macaca; Malaria; Mefloqui | 2022 |
Effect of adverse events on non-adherence and study non-completion in malaria chemoprevention during pregnancy trial: A nested case control study.
Topics: Antimalarials; Case-Control Studies; Chemoprevention; Chloroquine; Data Analysis; Drug Combinations; | 2022 |
Rutin ameliorates malaria pathogenesis by modulating inflammatory mechanism: an in vitro and in vivo study.
Topics: Animals; Antimalarials; Chloroquine; Female; Humans; Malaria; Mice; Plasmodium berghei; Pregnancy; R | 2022 |
Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases.
Topics: Animals; Antimalarials; Chloroquine; Dengue; Insecticides; Larva; Malaria; Metal Nanoparticles; Mice | 2022 |
Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers.
Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artesunate; Child | 2022 |
Decoding the Role of Melatonin Structure on
Topics: Animals; Chloroquine; Humans; Indoles; Malaria; Malaria, Falciparum; Melatonin; Parasitemia; Parasit | 2022 |
Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Mass Spectrometry | 2022 |
Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV pathogen box.
Topics: Access to Information; Antimalarials; Artemisinins; Chloroquine; Humans; Malaria; Plasmodium falcipa | 2022 |
Effect of black seeds (Nigella sativa) on inflammatory and immunomodulatory markers in Plasmodium berghei-infected mice.
Topics: Animals; Antimalarials; Antioxidants; Biomarkers; Chloroquine; Glutathione; Immunity; Immunoglobulin | 2022 |
Antimalarial Pyrido[1,2-
Topics: Aminoquinolines; Animals; Antimalarials; Antiparasitic Agents; Benzimidazoles; Chloroquine; Folic Ac | 2022 |
Genetic Diversity of Plasmodium falciparum and Distribution of Antimalarial Drug Resistance Mutations in Symptomatic and Asymptomatic Infections.
Topics: Antimalarials; Asymptomatic Infections; Chloroquine; Drug Resistance; Folic Acid Antagonists; Genoty | 2022 |
The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Membrane Transport Proteins; Oligo | 2022 |
Impact of Chemoprophylaxis on Plasmodium vivax and Plasmodium ovale Infection Among Civilian Travelers: A Nested Case-Control Study With a Counterfactual Approach on 862 Patients.
Topics: Antimalarials; Atovaquone; Case-Control Studies; Chemoprevention; Chloroquine; Humans; Malaria; Mala | 2023 |
Drug resistance and population structure of Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Mal | 2022 |
Impact of prophylactic antimalarials in pregnant women living with Human Immunodeficiency Virus on birth outcomes in Botswana.
Topics: Antimalarials; Botswana; Chloroquine; Female; HIV; HIV Infections; Humans; Infant, Newborn; Malaria; | 2022 |
High prevalence of Pfcrt 76T and Pfmdr1 N86 genotypes in malaria infected patients attending health facilities in East Shewa zone, Oromia Regional State, Ethiopia.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Chloroquine; Drug Resistance; | 2022 |
Antiplasmodial and Antimalarial Activity of 3,5-Diarylidenetetrahydro-2H-pyran-4(3H)-ones via Inhibition of Plasmodium falciparum Pyridoxal Synthase.
Topics: Animals; Antimalarials; Body Weight; Chloroquine; Malaria; Mice; Plasmodium falciparum | 2023 |
An Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium yoelii; Protozoan Proteins | 2022 |
Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues.
Topics: Acetylene; Alkynes; Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Fa | 2022 |
Chloroquine treatment influences immunologicalmemory through the PD-1/PD-L1 pathway during the initiation of Plasmodium chabaudi infection.
Topics: Animals; B7-H1 Antigen; Chloroquine; Immunoglobulin G; Malaria; Mice; Plasmodium chabaudi; Programme | 2022 |
Chloroquine treatment influences immunologicalmemory through the PD-1/PD-L1 pathway during the initiation of Plasmodium chabaudi infection.
Topics: Animals; B7-H1 Antigen; Chloroquine; Immunoglobulin G; Malaria; Mice; Plasmodium chabaudi; Programme | 2022 |
Chloroquine treatment influences immunologicalmemory through the PD-1/PD-L1 pathway during the initiation of Plasmodium chabaudi infection.
Topics: Animals; B7-H1 Antigen; Chloroquine; Immunoglobulin G; Malaria; Mice; Plasmodium chabaudi; Programme | 2022 |
Chloroquine treatment influences immunologicalmemory through the PD-1/PD-L1 pathway during the initiation of Plasmodium chabaudi infection.
Topics: Animals; B7-H1 Antigen; Chloroquine; Immunoglobulin G; Malaria; Mice; Plasmodium chabaudi; Programme | 2022 |
Targeting malaria parasites with novel derivatives of azithromycin.
Topics: Animals; Antimalarials; Azithromycin; Chloroquine; Humans; Malaria; Malaria, Falciparum; Parasites; | 2022 |
Hitting drug-resistant malaria infection with triazole-linked flavonoid-chloroquine hybrid compounds.
Topics: Antimalarials; Chloroquine; Flavonoids; Humans; Malaria; Plasmodium falciparum; Triazoles | 2022 |
New Iron Twist to Chloroquine─Upgrading Antimalarials with Immunomodulatory and Antimicrobial Features.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Iron; Malaria; Plasmodium falciparum | 2023 |
Challenges Based on Antiplasmodial and Antiviral Activities of 7-Chloro-4-aminoquinoline Derivatives.
Topics: Antimalarials; Antiviral Agents; Chloroquine; COVID-19; Humans; Malaria; Plasmodium falciparum; SARS | 2023 |
IFNγ, TNFα polymorphisms and IFNγ serum levels are associated with the clearance of drug-resistant P. falciparum in Malian children.
Topics: Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Membrane T | 2023 |
Quantification of parasite clearance in Plasmodium knowlesi infections.
Topics: Animals; Antimalarials; Artemisinins; Bayes Theorem; Chloroquine; Humans; Malaria; Parasitemia; Para | 2023 |
Effect of liquiritigenin on chloroquine accumulation in digestive vacuole leading to apoptosis-like death of chloroquine-resistant P. falciparum.
Topics: Animals; Antimalarials; Apoptosis; Chloroquine; Chromatography, Liquid; Disease Models, Animal; Drug | 2023 |
Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana.
Topics: Antimalarials; Chloroquine; Ghana; Humans; Malaria; Malaria, Falciparum; Plasmodium falciparum; Plas | 2023 |
Monitoring antimalarial drug-resistance markers in Somalia.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Plasmodium falciparum; Somalia | 2023 |
Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Dogs; Malaria; Malaria, Falciparum; Plasmodium fa | 2023 |
Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Chloroquine; Drug Resistance; | 2023 |
Two transporters enable chloroquine resistance in malaria.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Membrane Transport Proteins | 2023 |
Antiplasmodial Activity Evaluation of a Bestatin-Related Aminopeptidase Inhibitor, Phebestin.
Topics: Aminopeptidases; Animals; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Mice; Pa | 2023 |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Vivax; Plasmodium vivax; P | 2023 |
Development of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation.
Topics: Antimalarials; Chloroquine; Endothelial Cells; Humans; Lab-On-A-Chip Devices; Malaria; Malaria, Falc | 2023 |
Topics: Antimalarials; Chloroquine; Heme; Humans; Malaria | 2023 |
Rebound of multiple infections and prevalence of anti-malarial resistance associated markers following malaria upsurges in Dielmo village, Senegal, West Africa.
Topics: Africa, Western; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Membrane Transpor | 2023 |
Geo-environmental factors and the effectiveness of mulberry leaf extract in managing malaria.
Topics: Chloroquine; Malaria; Malaria, Falciparum; Methanol; Morus; Plant Extracts | 2023 |
Structure-Activity Relationships and Antiplasmodial Potencies of Novel 3,4-Disubstituted 1,2,5-Oxadiazoles.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Plasmodium falciparum; Structure-A | 2023 |
Molecular surveillance of chloroquine resistance in Plasmodium vivax isolates from malaria cases in Yunnan Province of China using pvcrt-o gene polymorphisms.
Topics: Antimalarials; China; Chloroquine; Cohort Studies; Drug Resistance; Humans; Malaria; Malaria, Vivax; | 2023 |
Anti-malarial and haematological evaluation of the ethanolic, ethyl acetate and aqueous fractions of Chromolaena odorata.
Topics: Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Chloroquine; Chromolaena; Malaria | 2023 |
Rapid profiling of Plasmodium parasites from genome sequences to assist malaria control.
Topics: Animals; Antimalarials; Chloroquine; Coinfection; Drug Resistance; Humans; Malaria; Malaria, Falcipa | 2023 |
Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Crosses, Genetic; Culicidae; Drug Discovery; Drug Re | 2019 |
Highly Sensitive and Rapid Characterization of the Development of Synchronized Blood Stage Malaria Parasites Via Magneto-Optical Hemozoin Quantification.
Topics: Animals; Blood Chemical Analysis; Chloroquine; Disease Models, Animal; Early Diagnosis; Female; Heme | 2019 |
Improving the immunogenicity and protective efficacy of a whole-killed malaria blood-stage vaccine by chloroquine.
Topics: Adjuvants, Immunologic; Alum Compounds; Animals; Antibodies, Protozoan; B-Lymphocytes; Chloroquine; | 2020 |
Discovery and Pharmacophore Mapping of a Low-Nanomolar Inhibitor of P. falciparum Growth.
Topics: Amines; Animals; Antimalarials; Chloroquine; Dogs; Dose-Response Relationship, Drug; Drug Evaluation | 2019 |
Potential antimalarial activity of Coccinia barteri leaf extract and solvent fractions against Plasmodium berghei infected mice.
Topics: Animals; Antimalarials; Chloroquine; Cucurbitaceae; Disease Models, Animal; Female; Malaria; Male; M | 2020 |
Mathematical models for within-host competition of malaria parasites.
Topics: Algorithms; Animals; Antimalarials; Chloroquine; Computer Simulation; Drug Resistance; Host-Parasite | 2019 |
Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh.
Topics: Antimalarials; Blood Transfusion; Child; Chloroquine; Glucosephosphate Dehydrogenase Deficiency; Hem | 2020 |
Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; CD11 Antigens; Chloroquine; Disease Models, Animal | 2019 |
Discovery of potential 1,3,5-Triazine compounds against strains of Plasmodium falciparum using supervised machine learning models.
Topics: Antimalarials; Chloroquine; Machine Learning; Malaria; Parasitemia; Plasmodium falciparum; Triazines | 2020 |
Deployment and Travel Medicine Knowledge, Attitudes, Practices, and Outcomes Study (KAPOS): Malaria Chemoprophylaxis Prescription Patterns in the Military Health System.
Topics: Adolescent; Adult; Aged; Antimalarials; Atovaquone; Chemoprevention; Chloroquine; Doxycycline; Drug | 2020 |
Malaria in the pregnant traveler.
Topics: Antimalarials; Chemoprevention; Chloroquine; Drug Resistance; Female; Humans; Malaria; Mefloquine; P | 2020 |
Mass intake of hydroxychloroquine or chloroquine in the present context of the Covid-19 outbreak: Possible consequences in endemic malaria settings.
Topics: Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Resist | 2020 |
Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype?
Topics: Anti-Inflammatory Agents; Antiviral Agents; Autophagy; Chloroquine; COVID-19; COVID-19 Drug Treatmen | 2020 |
Janus sword actions of chloroquine and hydroxychloroquine against COVID-19.
Topics: Antimalarials; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; Cyt | 2020 |
Concentration-dependent mortality of chloroquine in overdose.
Topics: Adult; Antimalarials; Biotransformation; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Dru | 2020 |
Increasing Malaria Parasite Clearance Time after Chloroquine Therapy, South Korea, 2000-2016.
Topics: Animals; Antimalarials; Chloroquine; Drug Therapy, Combination; Malaria; Malaria, Vivax; Parasites; | 2020 |
Antimalarial drug resistance molecular makers of Plasmodium falciparum isolates from Sudan during 2015-2017.
Topics: Adolescent; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Membr | 2020 |
No evidence that chloroquine or hydroxychloroquine induce hemolysis in G6PD deficiency.
Topics: Antimalarials; Chloroquine; COVID-19 Drug Treatment; Enzyme Inhibitors; Glucosephosphate Dehydrogena | 2020 |
Exposure to chloroquine in male adults and children aged 9-11 years with malaria due to Plasmodium vivax.
Topics: Adult; Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Vivax; Male; Pl | 2021 |
Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria.
Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Cytochrome P-450 CYP2C8; Drug Resistan | 2020 |
Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Plasmodium; Primaquine | 2020 |
A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides.
Topics: Animals; Antimalarials; Azithromycin; Chloroquine; Dogs; Malaria; Mice; Plasmodium falciparum; Rats | 2021 |
A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent.
Topics: Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Gold; Humans; Malaria; Molecular Struc | 2021 |
Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana.
Topics: Amodiaquine; Antimalarials; Biomarkers, Pharmacological; Carrier State; Child, Preschool; Chloroquin | 2020 |
Antiplasmodial activity of sulfonylhydrazones:
Topics: Antimalarials; Cell Line; Cell Survival; Chloroquine; Drug Resistance; Humans; Hydrazones; Life Cycl | 2021 |
Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study.
Topics: Adult; Aged; Blood Coagulation; Chloroquine; Coinfection; Comorbidity; Cough; COVID-19; COVID-19 Dru | 2020 |
Treatment of COVID-19 with Chloroquine: Implication for Malaria Chemotherapy Using ACTs in Disease Endemic Countries.
Topics: Amodiaquine; Chloroquine; COVID-19 Drug Treatment; Drug Resistance; Humans; Malaria; Plasmodium | 2021 |
Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification.
Topics: Animals; Antimalarials; Artesunate; Cassia; Chloroquine; Heme; Ketones; Malaria; Male; Mice, Inbred | 2021 |
Progression of malaria induced pathogenicity during chloroquine therapy.
Topics: Animals; Antimalarials; Chloroquine; Disease Progression; Malaria; Mice, Inbred ICR; Parasitemia; Pl | 2020 |
Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei.
Topics: Analysis of Variance; Anemia; Animals; Antimalarials; Brain; Chloroquine; Dose-Response Relationship | 2021 |
Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate.
Topics: Amodiaquine; Animals; Antimalarials; Autophagy; Autophagy-Related Proteins; Biological Transport; Ch | 2021 |
Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment.
Topics: Antimalarials; Child; Chloroquine; Drug Resistance; Gabon; Humans; Malaria; Malaria, Falciparum; Pla | 2021 |
A novel nano-anti-malarial induces redox damage and elicits cytokine response to the parasite.
Topics: Animals; Antimalarials; Cells, Cultured; Chitosan; Chloroquine; Cytokines; Drug Resistance; Humans; | 2021 |
In-vivo anti-plasmodial activity of phosphate buffer extract of Calotropis procera latex in mice infected with Plasmodium berghei.
Topics: Animals; Antimalarials; Calotropis; Chloroquine; Dose-Response Relationship, Drug; Female; Latex; Le | 2021 |
Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes.
Topics: Antimalarials; Chemistry, Pharmaceutical; Chloroquine; Cholesterol; Drug Compounding; Drug Liberatio | 2021 |
Developmental stages influence in vivo antimalarial activity of aerial part extracts of Schkuhria pinnata.
Topics: Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Asteraceae; Chloroquine; Dose-Res | 2021 |
Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii.
Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug The | 2021 |
Evaluation of the effect of probiotic as add-on therapy with conventional therapy and alone in malaria induced mice.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Mice; Parasitemia; Probiotics | 2021 |
In vivo antimalarial activity of a probiotic bacterium Lactobacillus sakei isolated from traditionally fermented milk in BALB/c mice infected with Plasmodium berghei ANKA.
Topics: Animals; Antimalarials; Cameroon; Chloroquine; Disease Models, Animal; Drug Combinations; Fermented | 2021 |
Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status.
Topics: Adult; Antimalarials; Chloroquine; Fever; Humans; Liberia; Malaria; Malaria, Vivax; Male; Molecular | 2017 |
Molecular Profile of Malaria Drug Resistance Markers of Plasmodium falciparum in Suriname.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Genotype; Malaria; Mutation; Plasmodium f | 2017 |
A phenolic glycoside from Flacourtia indica induces heme mediated oxidative stress in Plasmodium falciparum and attenuates malaria pathogenesis in mice.
Topics: Animals; Antimalarials; Chloroquine; Glycosides; Heme; Malaria; Male; Mice; Oxidative Stress; Phenol | 2017 |
Effective-Loading of Platinum-Chloroquine into PEGylated Neutral and Cationic Liposomes as a Drug Delivery System for Resistant Malaria Parasites.
Topics: Antimalarials; Chloroquine; Drug Delivery Systems; Drug Liberation; Drug Resistance; Lipids; Liposom | 2017 |
Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; DNA, Pro | 2017 |
The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials.
Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Malaria; Oxygen; Primaquine; Protein Biosynth | 2017 |
Progressive increase in point mutations associates chloroquine resistance: Even after withdrawal of chloroquine use in India.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Coinfection; Drug Resi | 2017 |
Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Drug Synergism; Drug Ther | 2017 |
Assessment of liver antioxidant status and mitochondrial membrane composition of Plasmodium berghei-infected mice treated with selected antimalarials.
Topics: Animals; Antimalarials; Antioxidants; Body Weight; Chloroquine; Liver; Malaria; Male; Mice; Mitochon | 2017 |
Recrudescing Plasmodium malariae infection despite appropriate treatment in an immigrant toddler.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Atovaquone; Chloroquine; Communicable Dise | 2018 |
In vivo and in vitro Models for Scanning Drug Substances in Malaria: Prestudy.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclini | 2017 |
A young man with severe acute haemolytic anaemia.
Topics: Antimalarials; Chloroquine; Drug Therapy, Combination; Glucosephosphate Dehydrogenase Deficiency; Hu | 2017 |
In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine.
Topics: Alkaloids; Antimalarials; Chloroquine; Ethanolamines; Fluorenes; Gametogenesis; Ghana; Humans; Indol | 2017 |
Novel arylidene derivatives of quinoline based thiazolidinones: Synthesis, in vitro, in vivo and in silico study as antimalarials.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Malaria; Mice; Plasmodium berghe | 2018 |
Prediction Model for Antimalarial Activities of Hemozoin Inhibitors by Using Physicochemical Properties.
Topics: Animals; Antimalarials; Bayes Theorem; Chloroquine; Hemeproteins; Humans; Malaria; Mefloquine; Plasm | 2018 |
Promising approach to reducing Malaria transmission by ivermectin: Sporontocidal effect against Plasmodium vivax in the South American vectors Anopheles aquasalis and Anopheles darlingi.
Topics: Animals; Anopheles; Brazil; Chloroquine; Dose-Response Relationship, Drug; Drug Combinations; Female | 2018 |
Severe Plasmodium ovale malaria complicated by acute respiratory distress syndrome in a young Caucasian man.
Topics: Adult; Antimalarials; Chloroquine; Humans; Malaria; Male; Plasmodium ovale; Radiography, Thoracic; R | 2018 |
Improved efficacy of doxycycline in liposomes against Plasmodium falciparum in culture and Plasmodium berghei infection in mice.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Doxycycline; Drug Carriers; Drug Resist | 2018 |
[Polymorphism of 72-76 Coding Sequence within Exon 2 Region of Pfcrt in Yunnan Province].
Topics: Africa; Amino Acid Sequence; Antimalarials; Base Sequence; China; Chloroquine; Drug Resistance; Exon | 2016 |
[Diagnosis and Treatment of the First Imported Case of Plasmodium knowlesi Infection in China].
Topics: Animals; Antimalarials; Artemisinins; China; Chloroquine; Erythrocytes; Hemeproteins; Humans; Malari | 2016 |
In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Male; Mice; Parasitemia; Plas | 2018 |
Back to chloroquine for malaria prophylaxis in pregnancy?
Topics: Antimalarials; Chemoprevention; Chloroquine; Female; Humans; Malaria; Malawi; Pregnancy | 2018 |
Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity.
Topics: Animals; Antimalarials; Chloroquine; Drug Design; Drug Resistance; Hep G2 Cells; Humans; Malaria; Mi | 2018 |
Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.
Topics: Antimalarials; Arthritis, Rheumatoid; Chloroquine; Female; Gestational Age; Humans; Lupus Erythemato | 2019 |
Artemisinin Resistance Outside of Southeast Asia.
Topics: Africa South of the Sahara; Antimalarials; Artemisinins; Asia, Southeastern; Chloroquine; Drug Resis | 2018 |
Mixed Infection with
Topics: Adult; Antimalarials; Chloroquine; DNA, Protozoan; Humans; Malaria; Male; Plasmodium falciparum; Pla | 2019 |
Plasmodium vivax transcriptomes reveal stage-specific chloroquine response and differential regulation of male and female gametocytes.
Topics: Antimalarials; Cell Cycle; Chloroquine; Female; Gene Expression Regulation; Genes, Protozoan; Genome | 2019 |
Looking for Needles in the Plasmodial Haystack.
Topics: Antigens, Protozoan; Biomarkers; Chloroquine; Humans; Malaria; Needles; Plasmodium falciparum | 2019 |
Plasmodium malariae in a Spanish traveller returning from Colombia.
Topics: Adult; Chloroquine; Colombia; Female; Humans; Malaria; Plasmodium malariae; Spain; Travel | 2019 |
In vitro and in vivo studies on anti-malarial activity of Commiphora africana and Dichrostachys cinerea used by the Maasai in Arusha region, Tanzania.
Topics: Animals; Antimalarials; Chloroquine; Commiphora; Drug Resistance; Fabaceae; Female; In Vitro Techniq | 2019 |
[The treatment of malaria].
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Dru | 2019 |
Malaria infection promotes a selective expression of kinin receptors in murine liver.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Chloroquine; Gene Expression Regulatio | 2019 |
Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.
Topics: Alkaloids; Animals; Antimalarials; Caco-2 Cells; Cell Line; Cell Line, Tumor; Chloroquine; Female; H | 2019 |
Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Malaria; Male; Mice; Orchitis; Parasite | 2012 |
Prophylactic drugs for malaria: why do we need another one?
Topics: Adult; Antimalarials; Atovaquone; Chemoprevention; Child; Chloroquine; Developed Countries; Developi | 1999 |
Effect of chloroquine, methylene blue and artemether on red cell and hepatic antioxidant defence system in mice infected with Plasmodium yoelii nigeriensis.
Topics: Animals; Antimalarials; Antioxidants; Artemether; Artemisinins; Chloroquine; Erythrocytes; Liver; Ma | 2013 |
Preparation and characterization of chloroquine loaded microspheres for prophylactic use.
Topics: Antimalarials; Calorimetry, Differential Scanning; Chloroquine; Delayed-Action Preparations; Drug Co | 2013 |
Plasmodium knowlesi infection: a diagnostic challenge.
Topics: Adolescent; Antimalarials; Chloroquine; Diagnosis, Differential; Humans; Malaria; Male; Plasmodium k | 2013 |
A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Malaria; Parasit | 2013 |
Antimalarial potential of China 30 and Chelidonium 30 in combination therapy against lethal rodent malaria parasite: Plasmodium berghei.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chelidonium; Chloroquine; Cinchona; Female; Homeop | 2013 |
Therapeutic effects of various solvent fractions of Alstonia boonei (apocynaceae) stem bark on Plasmodium berghei-induced malaria.
Topics: Alstonia; Animals; Antimalarials; Chemical Fractionation; Chloroquine; Dose-Response Relationship, D | 2012 |
An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites.
Topics: Antimalarials; Artemisinins; Binding Sites; Chloroquine; Cysteine Endopeptidases; Cysteine Proteinas | 2013 |
In vitro and in vivo antimalarial activity and cytotoxicity of extracts and fractions from the leaves, root-bark and stem-bark of Triclisia gilletii.
Topics: Animals; Antimalarials; Cell Line; Cell Survival; Chloroquine; Drug Resistance, Multiple; Humans; Ma | 2013 |
A novel chitosan based antimalarial drug delivery against Plasmodium berghei infection.
Topics: Animals; Antimalarials; Chitosan; Chloroquine; Disease Models, Animal; DNA Damage; Drug Carriers; Dr | 2013 |
A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages.
Topics: Animals; Antimalarials; Blood; Chimera; Chloroquine; Disease Models, Animal; Female; Liver; Malaria; | 2013 |
Treatment of pregnant BALB/c mice with sulphadoxine pyrimethamine or chloroquine abrogates Plasmodium berghei induced placental pathology.
Topics: Animals; Antimalarials; Antioxidants; Chloroquine; DNA Fragmentation; Drug Combinations; Female; Lip | 2014 |
A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90).
Topics: Adenosine Triphosphatases; Animals; Antimalarials; Benzodioxoles; Chloroquine; Chromatography, Liqui | 2013 |
Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria.
Topics: Animals; Biological Availability; Cell Line, Tumor; Chemistry, Pharmaceutical; Chloroquine; Coated V | 2014 |
Oxidative stress and micronutrient therapy in malaria: an in vivo study in Plasmodium berghei infected mice.
Topics: Animals; Antioxidants; Artemisinins; Artesunate; Chloroquine; Dose-Response Relationship, Drug; Fema | 2013 |
Susceptibility of human Plasmodium knowlesi infections to anti-malarials.
Topics: Animals; Antimalarials; Artemisinins; Borneo; Chloroquine; Humans; Malaria; Mefloquine; Parasitic Se | 2013 |
Scrub typhus and malaria co-infection causing severe sepsis.
Topics: Animals; Anti-Bacterial Agents; Azithromycin; Chloroquine; Coinfection; Doxycycline; Enzyme-Linked I | 2014 |
CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii.
Topics: Animals; Antibodies, Protozoan; Antimalarials; CD8-Positive T-Lymphocytes; Chloroquine; Female; Mala | 2014 |
Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.
Topics: Analysis of Variance; Base Sequence; Chloroquine; Dihydroorotate Dehydrogenase; Drug Discovery; Drug | 2014 |
Antimalarial activity of plumbagin in vitro and in animal models.
Topics: Animals; Antimalarials; Biological Availability; Body Weight; Chloroquine; Disease Models, Animal; F | 2014 |
Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium.
Topics: Animals; Antimalarials; Chloroquine; Drug Carriers; Erythrocytes; Female; Malaria; Mice; Mice, Inbre | 2014 |
In vitro and in vivo antimalarial evaluations of myrtle extract, a plant traditionally used for treatment of parasitic disorders.
Topics: Animals; Cell Line; Chloroquine; Humans; Malaria; Mice; Myrtus; Plant Extracts; Plasmodium falciparu | 2013 |
Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice.
Topics: Analysis of Variance; Animals; Antimalarials; Antioxidants; Body Weight; Chloroquine; Flavonoids; Ga | 2014 |
N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity.
Topics: Antimalarials; Cell Line; Chloroquine; Drug Design; Drug Resistance; Humans; Malaria; Plasmodium ber | 2014 |
Insights following change in drug policy: a descriptive study for antimalarial prescription practices in children of public sector health facilities in Jharkhand state of India.
Topics: Adolescent; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Cross-Sec | 2013 |
CD8(+) T cells mediate robust stage-specific immunity to P. berghei under chemoprophylaxis and this protective environment is not downregulated by the presence of blood-stage infection.
Topics: Animals; Antimalarials; CD8-Positive T-Lymphocytes; Chemoprevention; Chloroquine; Combined Modality | 2014 |
Suppressive action of mepacrine, aphacrine, chloroquin, camoquin and proguanil against P. knowlesi in S. rhesus monkeys.
Topics: Amodiaquine; Animals; Chloroquine; Humans; Macaca mulatta; Malaria; Proguanil; Quinacrine | 1950 |
Comparison of the action of paludrine (proguanil), chloroquine and camoquin in single doses.
Topics: Amodiaquine; Chloroquine; Humans; Malaria; Proguanil | 1950 |
Camoquin and chloroquine in the treatment of malaria.
Topics: Amodiaquine; Chloroquine; Humans; Malaria | 1950 |
The treatment of Plasmodium falciparum malaria with a single dose antimalarial; a preliminary report of the use of hydroxychloroquine, 7-chloro-4(4-(N-ethyl-N-B-hydroxyethylamino)-1-methylbutylamino)-quinoline diphosphate.
Topics: Antimalarials; Chloroquine; Humans; Hydroxychloroquine; Malaria; Malaria, Falciparum; Quinolines | 1952 |
Antimalarial efficacy, cytotoxicity, and genotoxicity of methanolic stem bark extract from Hintonia latiflora in a Plasmodium yoelii yoelii lethal murine malaria model.
Topics: Administration, Oral; Animals; Antimalarials; Chloroquine; Malaria; Male; Medicine, Traditional; Met | 2014 |
Plasmodium vivax and Plasmodium falciparum ex vivo susceptibility to anti-malarials and gene characterization in Rondônia, West Amazon, Brazil.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Brazil; Chloroquine; DNA, Protozoan; Drug Resistance | 2014 |
Unexplained benefits of antibiotics in childhood: empiricism in need of enlightenment.
Topics: Antimalarials; Azithromycin; Chloroquine; Female; Gastrointestinal Diseases; Humans; Malaria; Male; | 2014 |
Influence of formulation ratio of the plant components on the antimalarial properties of MAMA decoction.
Topics: Animals; Antimalarials; Azadirachta; Chloroquine; Dose-Response Relationship, Drug; Drug Combination | 2014 |
High prevalence of pfcrt-CVIET haplotype in isolates from asymptomatic and symptomatic patients in south-central Oromia, Ethiopia.
Topics: Asymptomatic Infections; Chloroquine; Dried Blood Spot Testing; Drug Resistance; Ethiopia; Haplotype | 2014 |
In vivo splenic clearance correlates with in vitro deformability of red blood cells from Plasmodium yoelii-infected mice.
Topics: Anemia; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Erythrocyte Deformability; Fema | 2014 |
A prospective strategy to restore the tissue damage in malaria infection: Approach with chitosan-trypolyphosphate conjugated nanochloroquine in Swiss mice.
Topics: Animals; Antimalarials; Antioxidants; Biomarkers; Catalase; Cell Death; Chitosan; Chloroquine; Cytok | 2014 |
Artesunate versus chloroquine infection-treatment-vaccination defines stage-specific immune responses associated with prolonged sterile protection against both pre-erythrocytic and erythrocytic Plasmodium yoelii infection.
Topics: Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Artemisia; Artemisinins; Artesunate; Chlor | 2014 |
Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Child; Child, Preschool; Chloroquine; DNA | 2014 |
Validation of a chloroquine-induced cell death mechanism for clinical use against malaria.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Evaluation; Hemeproteins; Malaria; | 2014 |
"…still waiting for chloroquine": the challenge of communicating changes in first-line treatment policy for uncomplicated malaria in a remote Kenyan district.
Topics: Antimalarials; Chloroquine; Cross-Sectional Studies; Female; Health Communication; Health Education; | 2014 |
Compliance to recommendations for the management of curative treatment of Plasmodium vivax/ovale infections.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Guideline Adherence; Humans; Malaria; Malaria, | 2014 |
Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat province, Western Cambodia.
Topics: Anti-Infective Agents; Artemisinins; Cambodia; Chloroquine; Drug Resistance; Malaria; Plasmodium viv | 2014 |
Correlation of molecular markers, Pfmdr1-N86Y and Pfcrt-K76T, with in vitro chloroquine resistant Plasmodium falciparum, isolated in the malaria endemic states of Assam and Arunachal Pradesh, Northeast India.
Topics: Chloroquine; DNA Primers; Drug Resistance; Endemic Diseases; Genetic Markers; India; Linkage Disequi | 2014 |
Antiplasmodial activity-aided isolation and identification of quercetin-4'-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Cell Line; Chloroquine; Chromolaena; Drug Resistan | 2014 |
Protection against malaria by immunization with non-attenuated sporozoites under single-dose piperaquine-tetraphosphate chemoprophylaxis.
Topics: Animals; CD8-Positive T-Lymphocytes; Chemoprevention; Chloroquine; Disease Models, Animal; Female; I | 2014 |
Malaria prevention and treatment in pregnancy: survey of current practice among private medical practitioners in Lagos, Nigeria.
Topics: Adult; Antimalarials; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Nigeria; Practice Pat | 2015 |
Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Administration Schedule; Drug Ther | 2014 |
Exacerbation of autoimmune neuro-inflammation in mice cured from blood-stage Plasmodium berghei infection.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chloroquine; Encephalomyelitis, Aut | 2014 |
In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Malaria; Male; Mice; Minocycline; Paras | 2014 |
[Maculopathy in a lupus patient after taking antimalarial drugs].
Topics: Antimalarials; Chloroquine; Female; Fluorescein Angiography; Humans; Lupus Erythematosus, Systemic; | 2014 |
Early treatment with chloroquine inhibits the immune response against Plasmodium yoelii infection in mice.
Topics: Animals; Antimalarials; Chloroquine; Dendritic Cells; Disease Models, Animal; Disease Progression; F | 2014 |
Effect of selected local medicinal plants on the asexual blood stage of chloroquine resistant Plasmodium falciparum.
Topics: Animals; Antimalarials; Cattle; Cell Line; Chloroquine; Drug Resistance; Life Cycle Stages; Magnolio | 2014 |
Chitosan conjugated chloroquine: proficient to protect the induction of liver apoptosis during malaria.
Topics: Animals; Antimalarials; Apoptosis; Caspase 3; Caspase 9; Chitosan; Chloroquine; Drug Carriers; Gluta | 2015 |
Evaluation of malaria cases in individuals after traveling to endemic regions of the world.
Topics: Adult; Chloroquine; Doxycycline; Female; Humans; Malaria; Male; Quinine; Travel | 2014 |
Simultaneous administration of 2-aminoethyl diphenylborinate and chloroquine reverses chloroquine resistance in malaria parasites.
Topics: Animals; Antimalarials; Chloroquine; Female; Inhibitory Concentration 50; Malaria; Mice; Mice, Inbre | 2015 |
Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization.
Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Culicidae; Erythrocytes; Host-Parasite Interac | 2015 |
Amodiaquine-Ciprofloxacin: a potential combination therapy against drug resistant malaria.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Ciprofloxacin; Dose-Response Relationship, Drug; D | 2015 |
New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents.
Topics: Animals; Antimalarials; Chemistry Techniques, Synthetic; Chloroquine; Drug Design; Drug Evaluation, | 2015 |
Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria.
Topics: Animals; Antimalarials; CD8-Positive T-Lymphocytes; Chloroquine; Immunity, Cellular; Immunologic Mem | 2015 |
Molecular epidemiology and seroprevalence in asymptomatic Plasmodium falciparum infections of Malagasy pregnant women in the highlands.
Topics: Adolescent; Adult; Antibodies, Protozoan; Antimalarials; Asymptomatic Infections; Chloroquine; Drug | 2015 |
Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Cytoplasm; Drug Resistance; Erythrocy | 2015 |
Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin.
Topics: Animals; Artemisinins; Chloroquine; Drug Resistance; Glutamate-Cysteine Ligase; Glutathione; Malaria | 2015 |
Response of patent medicine vendors in rural areas of Lagos state Nigeria to antimalarial policy change.
Topics: Antimalarials; Artemisinins; Chloroquine; Commerce; Health Policy; Health Surveys; Humans; Interview | 2015 |
Contrasting ex vivo efficacies of "reversed chloroquine" compounds in chloroquine-resistant Plasmodium falciparum and P. vivax isolates.
Topics: Antimalarials; Chloroquine; Humans; Inhibitory Concentration 50; Malaria; Microbial Sensitivity Test | 2015 |
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.
Topics: Alleles; Chloroquine; Drug Resistance; Evolution, Molecular; French Guiana; Genetic Markers; Genome; | 2015 |
Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria.
Topics: Animals; Antimalarials; Bignoniaceae; Chloroquine; Drug Resistance; Female; Malaria; Male; Meliaceae | 2016 |
Chloroquine retinopathy: pattern of presentation in Ibadan, Sub-Sahara Africa.
Topics: Adult; Aged; Antimalarials; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Nigeria; Retina | 2016 |
Fever in the returning traveller: the importance of sensitivity.
Topics: Adult; Antimalarials; Cameroon; Chloroquine; Diagnosis, Differential; Fever; Follow-Up Studies; Huma | 2015 |
In vivo efficacy and bioavailability of lumefantrine: Evaluating the application of Pheroid technology.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Chemistry, Pharmaceutical; Ch | 2015 |
[13-year old girl with fever 6 months after returning from sub-Saharan Africa].
Topics: Adolescent; Africa; Chloroquine; Developing Countries; Female; Fever of Unknown Origin; Germany; Hum | 2015 |
Artemisinin-based combination therapy for knowlesi malaria.
Topics: Antimalarials; Artemisinins; Chloroquine; Female; Humans; Malaria; Male; Mefloquine; Plasmodium know | 2016 |
Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model.
Topics: Animals; Antimalarials; Blood Chemical Analysis; Chloroquine; Chromatography, Liquid; Disease Models | 2015 |
Antimalarial and cytotoxic properties of Chukrasia tabularis A. Juss and Turraea vogelii Hook F. Ex. Benth.
Topics: Animals; Antimalarials; Artemia; Artemisinins; Cell Survival; Chloroquine; Drug Resistance; Malaria; | 2016 |
Repetitive live sporozoites inoculation under arteether chemoprophylaxis confers protection against subsequent sporozoite challenge in rodent malaria model.
Topics: Animals; Antimalarials; Artemisinins; Chemoprevention; Chloroquine; Female; Immunization; Malaria; M | 2016 |
Inhibition of Glutathione Biosynthesis Sensitizes Plasmodium berghei to Antifolates.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Female; Glutamate-Cy | 2016 |
Potential antimalarial activity of Methyl Jasmonate and its effect on lipid profiles in Plasmodium Berghei infected mice.
Topics: Acetates; Animals; Antimalarials; Artemisinins; Chloroquine; Cyclopentanes; Malaria; Mice; Oxylipins | 2015 |
In vivo anti-plasmodial activities and toxic impacts of lime extract of a combination of Picralima nitida, Alstonia boonei and Gongronema latifolium in mice infected with Chloroquine-sensitive Plasmodium berghei.
Topics: Alstonia; Animals; Antimalarials; Apocynaceae; Calcium Compounds; Chloroquine; Dose-Response Relatio | 2015 |
Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Drug Ther | 2016 |
Adaptation of the [3H]Hypoxanthine Uptake Assay for In Vitro-Cultured Plasmodium knowlesi Malaria Parasites.
Topics: Animals; Antimalarials; Chloroquine; Clindamycin; Hypoxanthine; Inhibitory Concentration 50; Malaria | 2016 |
Malaria research and its influence on anti-malarial drug policy in Malawi: a case study.
Topics: Antimalarials; Artemether; Artemisinins; Biomedical Research; Chloroquine; Drug Combinations; Drug R | 2016 |
[Fever and chills in an 85-year-old woman].
Topics: Aged, 80 and over; Anemia, Sideroblastic; Antimalarials; Chills; Chloroquine; Diagnosis, Differentia | 2016 |
Does Malaria Cause Hypertension?
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Hypertension; Malaria; Malaria, Falciparum | 2016 |
Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Malaria; Mice; Organometallic Compounds | 2016 |
Antimalarial potential of leaves of Chenopodium ambrosioides L.
Topics: Animals; Antimalarials; Chenopodium ambrosioides; Chloroquine; Erythrocytes; Humans; Malaria; Mice; | 2016 |
[The first monkey malaria in Turkey: a case of Plasmodium knowlesi].
Topics: Adult; Animals; Anopheles; Antimalarials; Chloroquine; Erythrocytes; Humans; Malaria; Male; Mosquito | 2016 |
Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P. berghei infected Sprague-Dawley male rats.
Topics: Anemia; Animals; Antimalarials; Chloroquine; Malaria; Male; Parasitemia; Pentacyclic Triterpenes; Pl | 2016 |
Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda.
Topics: Adolescent; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Dru | 2016 |
Exploring the antimalarial potential of whole Cymbopogon citratus plant therapy.
Topics: Animals; Antimalarials; Chloroquine; Cymbopogon; Disease Models, Animal; Dose-Response Relationship, | 2016 |
Chloroquine-resistant Plasmodium vivax in Pakistan: an emerging threat.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Multidrug Resistance-Associated Protei | 2016 |
The Effects of Transdermally Delivered Oleanolic Acid on Malaria Parasites and Blood Glucose Homeostasis in P. berghei-Infected Male Sprague-Dawley Rats.
Topics: Administration, Cutaneous; Animals; Antimalarials; Blood Glucose; Chloroquine; Drug Therapy, Combina | 2016 |
Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy.
Topics: Administration, Oral; Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Dr | 2017 |
[Practices of caregivers and national recommendations for treatment of malaria in Benin in 2009].
Topics: Antimalarials; Artemisinins; Attitude of Health Personnel; Benin; Caregivers; Chloroquine; Cross-Sec | 2017 |
Anti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Female; Humans; Malaria; Malaria, Falci | 2017 |
In vivo efficacy of top five surveyed Ghanaian herbal anti-malarial products.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Female; | 2017 |
Quantitative characterization of hemozoin in Plasmodium berghei and vivax.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Hemeproteins; Liver; Malaria; Malaria, Vivax; | 2017 |
Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline.
Topics: Aminoquinolines; Animals; Antimalarials; Body Weight; Cell Line; Chloroquine; Humans; Malaria; Mice; | 2008 |
Immunomodulator effect of picroliv and its potential in treatment against resistant Plasmodium yoelii (MDR) infection in mice.
Topics: Animals; Antimalarials; B7-1 Antigen; B7-2 Antigen; Chloroquine; Cinnamates; Drug Resistance, Multip | 2008 |
Chloroquine mediated modulation of Anopheles gambiae gene expression.
Topics: Animals; Anopheles; Antimalarials; Apoptosis; Chloroquine; Gene Expression; Malaria; Oligonucleotide | 2008 |
Efficacy of intermittent preventive treatment versus chloroquine prophylaxis to prevent malaria during pregnancy in Benin.
Topics: Adult; Antimalarials; Benin; Chloroquine; Cross-Sectional Studies; Female; Humans; Infant, Low Birth | 2008 |
[Maturation of dendritic cells and activation of B-lymphocytes in spleens of ICR mice infected with chloroquine-resistant Plasmodium berghei].
Topics: Animals; B-Lymphocytes; Chloroquine; Dendritic Cells; Drug Resistance; Host-Parasite Interactions; M | 2008 |
Early home treatment of childhood fevers with ineffective antimalarials is deleterious in the outcome of severe malaria.
Topics: Age Factors; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Fever; Humans; Infant; Mal | 2008 |
Low validity of caretakers' reports on use of selected antimalarials and antibiotics in children with severe pneumonia at an urban hospital in Uganda.
Topics: Anti-Infective Agents; Antimalarials; Caregivers; Child, Preschool; Chloroquine; Cross-Sectional Stu | 2009 |
Acute respiratory distress syndrome in a case of Plasmodium ovale malaria.
Topics: Adult; Animals; Antimalarials; Chloroquine; Humans; Malaria; Male; Plasmodium ovale; Primaquine; Res | 2008 |
[Is the antimalarial fight effective in Mayotte?].
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Comoros; Drug Combinations; Female; Humans; | 2008 |
Transmission of different strains of Plasmodium cynomolgi to Aotus nancymaae monkeys and relapse.
Topics: Animals; Anopheles; Antimalarials; Aotidae; Chloroquine; Insect Vectors; Malaria; Monkey Diseases; P | 2009 |
Screening of medicinal plants from Reunion Island for antimalarial and cytotoxic activity.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance, | 2008 |
A field trial of chloroquine (SN 7618) as a suppressive against malaria in the Philippines.
Topics: Chloroquine; Humans; Malaria; Philippines; Quinine | 1948 |
Observations on the use of chloroquine in the treatment of acute malaria.
Topics: Chloroquine; Malaria | 1948 |
The efficacy of chloroquine, quinacrine, quinine and totaquine in the treatment of Plasmodium malariae infections (quartan malaria).
Topics: Chloroquine; Humans; Malaria; Plasmodium malariae; Quinacrine; Quinine | 1948 |
Malaria; observations on treatment with chloroquine (SN7618) and combined quinine and plasmochin.
Topics: Chloroquine; Humans; Malaria; Quinine | 1948 |
The termination of therapeutic malaria with chloroquine.
Topics: Chloroquine; Humans; Malaria; Therapeutics | 1948 |
Control of malaria in Central India (Madhya Pradesh): hope or hype?
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Fishes; Humans; India; Larva; Malaria; Pest Control, | 2009 |
Antiplasmodial activity of root extract and fractions of Croton zambesicus.
Topics: Animals; Antimalarials; Chloroquine; Croton; Female; Lethal Dose 50; Malaria; Male; Mice; Parasitemi | 2009 |
Poor knowledge on new malaria treatment guidelines among drug dispensers in private pharmacies in Tanzania: the need for involving the private sector in policy preparations and implementation.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Cross-Sectional | 2008 |
Perception and practice of malaria prophylaxis in pregnancy among primary health care providers in Ibadan, Nigeria.
Topics: Adolescent; Adult; Antimalarials; Awareness; Chloroquine; Cross-Sectional Studies; Female; Health Kn | 2008 |
Efficacy of monotherapies and artesunate-based combination therapies in children with uncomplicated malaria in Somalia.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug Com | 2009 |
Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage.
Topics: Animals; Antimalarials; Chloroquine; Erythrocyte Transfusion; Erythrocytes; Female; Immunity, Innate | 2008 |
Rolling back malaria initiative in India.
Topics: Animals; Antimalarials; Chloroquine; Fishes; Humans; India; Malaria; Pest Control, Biological | 2009 |
Reduced protective effect of Plasmodium berghei immunization by concurrent Schistosoma mansoni infection.
Topics: Animals; Antimalarials; Chloroquine; Female; Malaria; Mice; Mice, Inbred BALB C; Parasitemia; Plasmo | 2008 |
The development of a treatment guideline for childhood malaria in rural Southwest Nigeria using participatory approach.
Topics: Antimalarials; Audiovisual Aids; Case Management; Child; Child, Preschool; Chloroquine; Community-Ba | 2009 |
[Quality of malaria prevention during prenatal consultations in Niakhar (Senegal)].
Topics: Antimalarials; Chloroquine; Cross-Over Studies; Female; Humans; Malaria; Pregnancy; Pregnancy Compli | 2007 |
Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei.
Topics: Amino Acid Sequence; Animals; Antimalarials; ATP-Binding Cassette Transporters; Blotting, Southern; | 2009 |
Malaria in sub-Saharan Africa.
Topics: Antimalarials; Bedding and Linens; Burkina Faso; Chloroquine; Drug Resistance; Humans; Insecticides; | 2009 |
[Antimalarial's retinopaty remains a current threat].
Topics: Antimalarials; Arthritis, Rheumatoid; Chloroquine; Cohort Studies; Dose-Response Relationship, Drug; | 2009 |
Anti-malarials and Lupus in West Africa use and lupus in Africans.
Topics: Africa; Animals; Antimalarials; Black People; Chloroquine; Environment; Genetic Predisposition to Di | 2009 |
Effect of rutin and chloroquine on White Leghorn chickens infected with Plasmodium (Bennettinia) juxtanucleare.
Topics: Adrenal Cortex Hormones; Analysis of Variance; Animals; Antimalarials; Body Temperature; Body Weight | 2009 |
Impact of health education on home treatment and prevention of malaria in Jengre, North Central Nigeria.
Topics: Adolescent; Adult; Animals; Caregivers; Child, Preschool; Chloroquine; Female; Health Care Surveys; | 2008 |
Violacein extracted from Chromobacterium violaceum inhibits Plasmodium growth in vitro and in vivo.
Topics: Animals; Antimalarials; Chloroquine; Chromobacterium; Drug Resistance; Humans; Indoles; Malaria; Mal | 2009 |
Malaria - change in therapeutic policy.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Drug Resistance; Humans; Ma | 2009 |
In vivo antimalarial activity of leaves of Plectranthus amboinicus (lour) spreng on Plasmodium berghei yoelii.
Topics: Animals; Antimalarials; Chloroquine; Coleus; Female; Malaria; Male; Mice; Parasitemia; Parasitic Sen | 2008 |
Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Drug Resista | 2009 |
[Change of antimalarial first-line treatment in Burkina Faso in 2005].
Topics: Animals; Antimalarials; Burkina Faso; Child, Preschool; Chloroquine; Female; Health Policy; Hemoglob | 2009 |
Enhanced antimalarial effects of chloroquine by aqueous Vernonia amygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasmodium berghei strains.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Female; Malaria; Male; | 2008 |
Absence of an impact of resistance to chloroquine on consultations for malaria in Niakhar, Senegal (1992-2004).
Topics: Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Retrospective Studies; S | 2009 |
Monkey malaria in humans: a diagnostic dilemma with conflicting laboratory data.
Topics: Adult; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Humans; Malaria; Male; Plasmodium knowle | 2009 |
Drug resistance and in vitro susceptibility of Plasmodium falciparum in Thailand during 1988-2003.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Humans; Malaria; Mef | 2009 |
Antiretroviral protease inhibitors potentiate chloroquine antimalarial activity in malaria parasites by regulating intracellular glutathione metabolism.
Topics: Animals; Anti-Retroviral Agents; Antimalarials; Chloroquine; Drug Resistance; Drug Synergism; Female | 2009 |
Evaluation of in vivo antimalarial activities of ethanolic leaf and seed extracts of Telfairia occidentalis.
Topics: Animals; Antimalarials; Chloroquine; Cucurbitaceae; Female; Malaria; Male; Mice; Nigeria; Phytothera | 2009 |
Clinical and laboratory features of human Plasmodium knowlesi infection.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Blood Chemical Analysis; Chloroquine; Female; Hemog | 2009 |
Cardiotoxicity after low-dose chloroquine antimalarial therapy.
Topics: Administration, Oral; Antimalarials; Biopsy; Chloroquine; Heart Failure; Heart Ventricles; Humans; M | 2009 |
Evolution of malaria mortality and morbidity after the emergence of chloroquine resistance in Niakhar, Senegal.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Cause of Death; Child; Child, Preschool; Chloroquin | 2009 |
Dual labeling with a far red probe permits analysis of growth and oxidative stress in P. falciparum-infected erythrocytes.
Topics: Animals; Artemisinins; Catalase; Chloroquine; Cysteine Proteases; Erythrocytes; Flow Cytometry; Fluo | 2010 |
Antimalarial herbal remedies of Msambweni, Kenya.
Topics: Antimalarials; Chloroquine; Humans; Kenya; Malaria; Male; Materia Medica; Plants, Medicinal; Plasmod | 2010 |
Quinine for the treatment of malaria in pregnancy.
Topics: Animals; Antimalarials; Azithromycin; Chloroquine; Clindamycin; Drug Therapy, Combination; Female; H | 2010 |
Malaria among seamen in Klaipeda in 1999-2008.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Endemic Diseases; Female; Humans; Insect Vectors; Li | 2009 |
Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.
Topics: Amidohydrolases; Animals; Antimalarials; Candidiasis; Chagas Disease; Chloroquine; Cysteamine; Cytok | 2010 |
Treatment and prophylaxis of malaria with aralen.
Topics: Chloroquine; Humans; Malaria | 1947 |
Curative treatment of malaria with various salts of 3-methyl-4 (diethylaminopentyl) amino-7-chloroquinoline (nivaquine).
Topics: Chloroquine; Humans; Malaria | 1947 |
A controlled field trial of SN 7618-5 (chloroquine) for the suppression of malaria.
Topics: Animals; Chloroquine; Culicidae; Humans; Malaria | 1946 |
Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice.
Topics: Animals; Antimalarials; Carrier Proteins; Chloroquine; Immunity, Innate; Malaria; Mice; Mice, Inbred | 2010 |
Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine.
Topics: Acids; Animals; Antimalarials; Chloroquine; Hemeproteins; Hemin; Humans; Hydrogen-Ion Concentration; | 2010 |
[Monkey malaria in a traveller from Malaysia].
Topics: Adult; Antimalarials; Chloroquine; Humans; Malaria; Malaysia; Male; Plasmodium knowlesi; Travel; Tre | 2010 |
On the kinetics of formation of hemozoin, the malaria pigment.
Topics: 1-Octanol; Algorithms; Animals; Chloroquine; Hemeproteins; Hemin; Hexanols; Humans; Kinetics; Malari | 2010 |
Demand for malaria drug soars.
Topics: Agriculture; Artemisia annua; Artemisinins; Chloroquine; Drug Costs; Drug Resistance; Humans; Malari | 2010 |
Perception and practice of malaria prophylaxis in pregnancy among health care providers in Ibadan.
Topics: Antimalarials; Chloroquine; Community Health Services; Drug Combinations; Female; Guideline Adherenc | 2007 |
Retinopathy due to antimalarial drugs in patients with connective tissue diseases: are they so innocent? A single center retrospective study.
Topics: Adolescent; Adult; Aged; Antimalarials; Arthritis, Rheumatoid; Chi-Square Distribution; Chloroquine; | 2010 |
Antimalarial activity of traditionally used Western Ghats plants from India and their interactions with chloroquine against chloroquine-tolerant Plasmodium berghei.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Synergism; Ethnopharmacology; India; Inje | 2011 |
Plasmodium berghei K173: selection of resistance to naphthoquine in a mouse model.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance | 2011 |
TRIAL use of the new antimalarial drug chloroquine.
Topics: Antimalarials; Chloroquine; Humans; Malaria | 1946 |
Chloroquine for treatment of acute attacks of vivax malaria.
Topics: Animals; Behavior, Animal; Chloroquine; Humans; Malaria; Malaria, Vivax; Quinine; Social Behavior | 1946 |
ACTIVITY of a new antimalarial agent, chloroquine (SN 7618).
Topics: Anaphylaxis; Antimalarials; Chloroquine; Humans; Hypersensitivity; Immune System Diseases; Malaria; | 1946 |
Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Codon; Cross-Se | 2010 |
Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives.
Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance; Humans; In Vitro T | 2011 |
In vivo antimalarial activities of ethanolic crude extracts and fractions of leaf and root of Carpolobia lutea.
Topics: Animals; Antimalarials; Chloroform; Chloroquine; Ethanol; Female; Malaria; Male; Mice; Plant Extract | 2011 |
[Plasmodium ovale malaria severity].
Topics: Adult; Antimalarials; Chloroquine; Female; Ghana; Humans; Malaria; Male; Nigeria; Plasmodium ovale; | 2011 |
Variant Plasmodium ovale isolated from a patient infected in Ghana.
Topics: Animals; Antimalarials; Chloroquine; Cysteine Proteases; Cytochromes b; Denmark; Electron Transport | 2011 |
Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes.
Topics: Animals; Antimalarials; Chloroquine; Culicidae; Disease Models, Animal; Drug Resistance; Female; Mal | 2011 |
A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases.
Topics: Animals; Apoptosis; Calcium; Chloroquine; Cysteine Proteases; DNA; DNA Fragmentation; Dose-Response | 2010 |
Suppression of Plasmodium berghei parasitemia by LiCl in an animal infection model.
Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Disease Models, Animal; Glycogen Synthase Kina | 2010 |
Toward understanding the chloroquine action at the molecular level in antimalarial therapy--X-ray absorption studies in acetic acid solution.
Topics: Acetic Acid; Antimalarials; Chloroquine; Hemeproteins; Humans; Malaria; Models, Molecular; X-Ray Abs | 2011 |
Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing.
Topics: Animals; CD11b Antigen; Chloroquine; Erythrocyte Count; Erythrocytes; Flow Cytometry; Hemeproteins; | 2011 |
[Duodenal ulcers caused by chloroquine-proguanil association].
Topics: Adult; Antimalarials; Chemoprevention; Chloroquine; Drug Combinations; Duodenal Ulcer; Humans; Malar | 2010 |
Plasmodium knowlesi malaria in children.
Topics: Adolescent; Age Factors; Anemia; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans | 2011 |
Synergy of the antiretroviral protease inhibitor indinavir and chloroquine against malaria parasites in vitro and in vivo.
Topics: Animals; Antimalarials; Chloroquine; Coinfection; Drug Synergism; Female; HIV Infections; HIV Protea | 2011 |
Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Chromatography, High Pressure Liquid; Disease Mod | 2011 |
Chemotherapeutic interaction between Khaya grandifoliola (WELW) CDC stem bark extract and two anti-malarial drugs in mice.
Topics: Administration, Oral; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Ad | 2010 |
Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia.
Topics: Acute Kidney Injury; Adult; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Ethano | 2011 |
Comparative efficacy of pre-erythrocytic whole organism vaccine strategies against the malaria parasite.
Topics: Animals; Azithromycin; CD8-Positive T-Lymphocytes; Chloroquine; Erythrocytes; Female; Liver; Malaria | 2011 |
Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta).
Topics: Aminoquinolines; Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Ch | 2011 |
Combining community case management and intermittent preventive treatment for malaria.
Topics: Africa; Antimalarials; Case Management; Child; Child, Preschool; Chloroquine; Community Health Servi | 2011 |
Improvements in compliance with medical force protection measures by simplification of the anti-malarial chemoprophylaxis regime.
Topics: Animals; Antimalarials; Belize; Chemoprevention; Chloroquine; Doxycycline; Humans; Insect Bites and | 2011 |
[Comparison of efficacy of chloroquine versus sulfadoxine-pyrimethamine in malaria prevention in pregnant women in the Toamasina region (Madagascar)].
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Drug Combinations; Endemic Diseases; Female; Humans; | 2011 |
Interaction between ciprofloxacin and chloroquine in mice infected with chloroquine resistant Plasmodium berghei: interaction between ciprofloxacin and chloroqune.
Topics: Animals; Antimalarials; Chloroquine; Ciprofloxacin; Disease Models, Animal; Drug Resistance; Drug Th | 2012 |
Utilisation of malaria preventive measures during pregnancy and birth outcomes in Ibadan, Nigeria.
Topics: Adult; Animals; Antimalarials; Attitude to Health; Chloroquine; Drug Combinations; Female; Health Pr | 2011 |
The next opportunity in anti-malaria drug discovery: the liver stage.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Discovery; Drug Resistance, Microbial; Humans; Liver; | 2011 |
A partial convergence in action of methylene blue and artemisinins: antagonism with chloroquine, a reversal with verapamil, and an insight into the antimalarial activity of chloroquine.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Synergism; Flavin-Adenine D | 2011 |
A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon.
Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; DNA, Protozoan; Drug Combinations; Drug Resis | 2011 |
Antimalarial chemoprophylaxis in a deployed Naval Unit.
Topics: Adult; Antimalarials; Chloroquine; Humans; Malaria; Naval Medicine; Patient Compliance; Proguanil; U | 2011 |
Prophylactic use of antimalarials during pregnancy.
Topics: Antimalarials; Atovaquone; Chemoprevention; Chloroquine; Doxycycline; Drug Combinations; Female; Hum | 2011 |
Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Monitoring; Female; Humans; Infant; Infant | 2011 |
Evaluation of immunity against malaria using luciferase-expressing Plasmodium berghei parasites.
Topics: Animals; Anopheles; Chloroquine; Diagnostic Imaging; Female; Genes, Reporter; Green Fluorescent Prot | 2011 |
In vivo antiplasmodial activities of aqueous extract of Bridelia ferruginea stem bark against Plasmodium berghei berghei in mice.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Eupho | 2012 |
Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.
Topics: Aging; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Cohort Studies | 2012 |
[Plan to improve malaria control towards its elimination in Mesoamerica].
Topics: Animals; Antimalarials; Central America; Chloroquine; Community Participation; Developing Countries; | 2011 |
Mosquito infection studies with Aotus monkeys and humans infected with the Chesson strain of Plasmodiun vivax.
Topics: Animals; Anopheles; Antimalarials; Aotidae; Chloroquine; Disease Management; Disease Models, Animal; | 2012 |
Malaria in seasonal migrant population in Southern Gujarat, India.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Animals; Antimalarials; Blood; Child; | 2011 |
Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Animals; Antimalarials; Chloroquine; DNA Mutation | 2012 |
Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C.
Topics: Animals; Antimalarials; Asteraceae; Cell Line; Chloroquine; Disease Models, Animal; Female; Humans; | 2012 |
Sontochin as a guide to the development of drugs against chloroquine-resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Inhibitory Concentration 50; Malaria; Mice; Mo | 2012 |
Vaccines: The take-home lesson.
Topics: Animals; Chloroquine; Clinical Trials as Topic; Culicidae; Feeding Behavior; Genetic Engineering; Hu | 2012 |
Anti-malarial chemoprophylaxis following evacuation from Afghanistan.
Topics: Afghan Campaign 2001-; Antimalarials; Atovaquone; Chemoprevention; Chloroquine; Clinical Audit; Doxy | 2012 |
Patterns of case management and chemoprevention for malaria-in-pregnancy by public and private sector health providers in Enugu state, Nigeria.
Topics: Adult; Antimalarials; Case Management; Chemoprevention; Chloroquine; Drug Combinations; Female; Heal | 2012 |
Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells.
Topics: Animals; Antibodies, Protozoan; Antimalarials; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocyte | 2012 |
Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Synergism; Harmaline; Harmine; HSP90 Heat-Sh | 2012 |
Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites.
Topics: Aminoquinolines; Animals; Antimalarials; Cell Line, Tumor; Chloroquine; Dose-Response Relationship, | 2012 |
Synthesis, characterization of chitosan-tripolyphosphate conjugated chloroquine nanoparticle and its in vivo anti-malarial efficacy against rodent parasite: a dose and duration dependent approach.
Topics: Animals; Antimalarials; Chitosan; Chloroquine; Disease Models, Animal; Dose-Response Relationship, D | 2012 |
Standby emergency treatment of malaria in travelers: experience to date and new developments.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Atovaquone; Chloroquine; Dia | 2012 |
Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro.
Topics: Administration, Oral; Aminoquinolines; Animals; Antimalarials; Cambodia; Chloroquine; Drug Administr | 2012 |
Source of clinical malaria in mixed-species infections.
Topics: Artemisinins; Chloroquine; Coinfection; Ethanolamines; Fluorenes; Humans; Malaria; Male; Plasmodium | 2012 |
Determinants of intermittent preventive treatment of malaria during pregnancy (IPTp) utilization in a rural town in Western Nigeria.
Topics: Adult; Antimalarials; Chemoprevention; Chloroquine; Cities; Cross-Sectional Studies; Drug Administra | 2012 |
Vaccination using normal live sporozoites under drug treatment.
Topics: Animals; Antimalarials; Chloroquine; Culicidae; Erythrocytes; Liver; Malaria; Malaria Vaccines; Mice | 2013 |
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhib | 2012 |
Tricks in Plasmodium's molecular repertoire--escaping 3'UTR excision-based conditional silencing of the chloroquine resistance transporter gene.
Topics: Animals; Antimalarials; Chloroquine; Culicidae; Drug Resistance; Gene Silencing; Malaria; Mice; Mice | 2012 |
Strain-specific protective effect of the immunity induced by live malarial sporozoites under chloroquine cover.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Female; Genes, Protozoan; Immunity, Active; Macaca; | 2012 |
Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Interactions; Ferric Compounds; Flavin-Adenine Dinucl | 2012 |
Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization.
Topics: Animals; Antimalarials; CD8-Positive T-Lymphocytes; Chloroquine; Disease Models, Animal; Gamma Rays; | 2012 |
Outcome of primary lethal and nonlethal Plasmodium yoelii malaria infection in BALB/c and IFN-γ receptor-deficient mice following chloroquine treatment.
Topics: Animals; Antibodies, Protozoan; Antimalarials; Chloroquine; Immunoglobulin G; Interferon gamma Recep | 2013 |
Too much to ask.
Topics: Africa; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans | 2012 |
Chemobiosynthesis of new antimalarial macrolides.
Topics: Antimalarials; Azithromycin; Chloroquine; Drug Resistance; Erythromycin; Macrolides; Malaria; Parasi | 2013 |
Psammaplysin derivatives from the Balinese marine sponge Aplysinella strongylata.
Topics: Animals; Antimalarials; Chloroquine; Fatty Acids; Gas Chromatography-Mass Spectrometry; Hydrocarbons | 2012 |
Fever in a 20-year-old returned traveler.
Topics: Antimalarials; Chloroquine; Female; Fever; Humans; Malaria; Plasmodium malariae; Travel; Treatment O | 2013 |
Ketoconazole, a cytochrome P(450) inhibitor can potentiate the antimalarial action of α/β arteether against MDR Plasmodium yoelii nigeriensis.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Multiple; Drug Synergism; Drug T | 2013 |
Diagnosis of malaria by detection of plasmodial lactate dehydrogenase with an immunodot enzyme assay.
Topics: Animals; Antibodies, Protozoan; Antibody Specificity; Antimalarials; Chloroquine; Humans; Immunoblot | 2002 |
[Many travellers suffer of side-effects of malaria prophylaxis].
Topics: Antimalarials; Chloroquine; Drug Eruptions; Gastrointestinal Diseases; Humans; Malaria; Mefloquine; | 2002 |
Plasmodium: assessment of the antimalarial potential of trifluralin and related compounds using a rat model of malaria, Rattus norvegicus.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Dinitrobenzenes; Disease Models, Animal; Eryth | 2002 |
Impact of health care financing reforms on the management of malaria in Ghana.
Topics: Antimalarials; Chloroquine; Cross-Sectional Studies; Delivery of Health Care; Drug Costs; Drug Presc | 2001 |
[Rapid detection of malaria and P. falciparum chemoresistant genotypes in Mayotte, 2001].
Topics: Adult; Animals; Chloroquine; Comoros; Drug Resistance; Genotype; Humans; Immunologic Tests; Infant; | 2002 |
Plasmodium chloroquine resistance and the search for a replacement antimalarial drug.
Topics: Alleles; Animals; Antimalarials; ATP-Binding Cassette Transporters; Biological Evolution; Chloroquin | 2002 |
Strategies to improve adherence to recommended chloroquine treatment regimes: a quasi-experiment in the context of integrated primary health care delivery in Ghana.
Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Chloroquine; Communication; Drug L | 2002 |
Studies on the antiplasmodial properties of some South African medicinal plants used as antimalarial remedies in Zulu folk medicine.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Fruit; Inhibitory Concentration 5 | 2002 |
Extended clearance time after treatment of infections with Plasmodium malariae may not be indicative of resistance to chloroquine.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium malariae; Treatmen | 2002 |
[Geographic approach in malaria control in the central highlands of Madagascar].
Topics: Altitude; Animals; Anopheles; Antimalarials; Chloroquine; DDT; Disease Outbreaks; Drug Resistance; E | 2001 |
[Studies on pharmacokinetics of chloroquine in mice infected with chloroquine-resistant strain of Plasmodium berghei].
Topics: Animals; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Drug Resistance; Female; | 2000 |
Relationship of chloroquine-induced redistribution of a neutral aminopeptidase to hemoglobin accumulation in malaria parasites.
Topics: Aminopeptidases; Anilides; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; En | 2003 |
Prophylactic effect of multi-herbal extract 'Agbo-Iba' on malaria induced in mice.
Topics: Administration, Oral; Animals; Antimalarials; Cajanus; Cassia; Chloroquine; Cymbopogon; Disease Mode | 2002 |
[Malaria study in the cyclone risk zone: entomological , diagnostic and therapeutic approach in the southeastern region of Madagascar].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anopheles; Antimalarials; Child; Child, Prescho | 2002 |
Chloroquine-induced masking of a lipid that promotes ferriprotoporphyrin IX dimerization in malaria.
Topics: Animals; Antimalarials; Chloroquine; Dimerization; Erythrocyte Aging; Erythrocyte Membrane; Hemin; M | 2003 |
Structural properties of dibenzosuberanylpiperazine derivatives for efficient reversal of chloroquine resistance in Plasmodium chabaudi.
Topics: Animals; Antimalarials; Chloroquine; Crystallography, X-Ray; Dibenzocycloheptenes; Drug Resistance, | 2003 |
Severe mucocutaneous necrotizing vasculitis associated with the combination of chloroquine and proguanil.
Topics: Antimalarials; Biopsy; Chloroquine; Drug Combinations; Drug Eruptions; Humans; Malaria; Male; Middle | 2003 |
Malaria in Austria 1990-2000.
Topics: Adolescent; Adult; Age Distribution; Animals; Austria; Chemoprevention; Child; Child, Preschool; Chl | 2003 |
The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Drug | 2003 |
Vendor-to-vendor education to improve malaria treatment by private drug outlets in Bungoma District, Kenya.
Topics: Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Commerce; Drug Combinations | 2003 |
[Imported malaria in 2000 in 2 northern Paris hospitals].
Topics: Africa; Antimalarials; Chemoprevention; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falc | 2003 |
Evaluation of the antimalarial properties and standardization of tablets of Azadirachta indica (Meliaceae) in mice.
Topics: Administration, Oral; Animals; Antimalarials; Azadirachta; Chloroquine; Malaria; Mice; Parasitic Sen | 2003 |
Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.
Topics: Acetaminophen; Acetylcysteine; Aminoquinolines; Animals; Antimalarials; Chloroquine; Disulfiram; Dru | 2003 |
Antimalarial effect of agmatine on Plasmodium berghei K173 strain.
Topics: Agmatine; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Eflornithine | 2003 |
Imported malaria in southern Taiwan from 1991 to 2002: a single hospital's experience.
Topics: Adolescent; Adult; Child; Chloroquine; Erythrocytes; Female; Humans; Malaria; Male; Middle Aged; Tai | 2003 |
Pattern of chloroquine-induced pruritus in antenatal patients at the University College Hospital, Ibadan.
Topics: Adult; Antimalarials; Chloroquine; Cross-Sectional Studies; Female; Humans; Malaria; Pregnancy; Preg | 2003 |
Cooperative actions to achieve malaria control without the use of DDT.
Topics: Animals; Anopheles; Antimalarials; Canada; Chloroquine; Cost-Benefit Analysis; DDT; Drug Combination | 2003 |
Comparative studies on chloroquine and resochin against simian and human malaria.
Topics: Chloroquine; Humans; Malaria | 1951 |
A study of falciparum malaria in Liberia and its treatment with chloroquine.
Topics: Chloroquine; Humans; Liberia; Malaria; Malaria, Falciparum | 1952 |
[Case of malaria due to Plasmodium falciparum resistant to quinacrine and to quinine and treated with nivaquine].
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum; Quinacrine; Quinine | 1952 |
[Massive injection of Plasmodium berghei into rat, for determination of effectiveness of an antimalarial; nivaquine].
Topics: Animals; Antimalarials; Chloroquine; Malaria; Plasmodium berghei; Quinolines; Rats | 1952 |
[Therapy of malaria with nivaquine B].
Topics: Chloroquine; Malaria; Quinolines; Uricosuric Agents | 1952 |
Clinical observation on resochin in the treatment of malaria.
Topics: Chloroquine; Humans; Malaria | 1953 |
Screening of antimalarials against P. gallinaceum in chicks.
Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chickens; Chloroquine; Malaria; Proguanil; Qui | 1952 |
Effect of parenteral-administration of antimalarials in simian malaria.
Topics: Antimalarials; Arsenicals; Chloroquine; Malaria; Quinine | 1952 |
[Suppressive malaria treatment with chloroquine in the Belgian Congo].
Topics: Child; Chloroquine; Democratic Republic of the Congo; Humans; Infant; Malaria | 1952 |
[Results of experiences with chloroquine, proguanil and amodiaquine in the prophylaxis of malaria].
Topics: Amodiaquine; Chloroquine; Humans; Malaria; Proguanil | 1952 |
Sidelights on chloroquine: two cases of interest.
Topics: Amebiasis; Chloroquine; Liver Diseases; Malaria | 1953 |
The out-patient treatment of malaria with single dose intramuscular chloroquine in a hyperendemic area in West Africa.
Topics: Africa, Western; Chloroquine; Injections, Intramuscular; Malaria; Outpatients | 1953 |
[Parenteral resochin therapy of various types of malaria].
Topics: Chloroquine; Malaria | 1953 |
[Parenteral resochin therapy].
Topics: Chloroquine; Malaria | 1953 |
[New method for the control of malaria by the use of drugs mixed with kitchen salt in daily diet].
Topics: Chloroquine; Diet; Humans; Malaria; Sodium Chloride; Sodium Chloride, Dietary | 1953 |
Chloroquine and chlorguanide as suppressants of malaria in Guatemala.
Topics: Chloroquine; Guatemala; Humans; Malaria; Proguanil | 1953 |
Korean vivax malaria. I. Natural history and response to chloroquine.
Topics: Chloroquine; Humans; Malaria; Malaria, Vivax | 1953 |
A comparison of the antimalarial effects of suppressive doses of chloroquine, amodiaquin, and pyrimethamine.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Pyrimethamine | 1954 |
Resochin; single dose therapy and mass suppression.
Topics: Chloroquine; Malaria | 1954 |
Nivaquine and camoquin in malaria.
Topics: Amodiaquine; Antimalarials; Chloroquine; Malaria; Quinolines | 1954 |
A fatal case of blackwater fever associated with ingestion of nivaquine.
Topics: Blackwater Fever; Chloroquine; Humans; Malaria; Quinolines | 1954 |
[Medicinal prophylaxis of malaria by monthly doses of chloroquine and amodiaquine].
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria | 1954 |
Pyrimethamine (daraprim) in malaria.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Pyrimethamine | 1953 |
Therapeutic trials with pyrimethamine (daraprim), resochin, amodiaquin (camoquin) and quinine.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Pyrimethamine; Quinine | 1953 |
[New method of malaria prevention: combination of an antimalarial drug with table salt used daily in food].
Topics: Antimalarials; Chloroquine; DDT; Food; Humans; Malaria; Sodium Chloride; Sodium Chloride, Dietary | 1954 |
Treatment of malaria with chloroquine.
Topics: Chloroquine; Malaria | 1954 |
The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Hydroxychloroquine; Malaria; Pyrimethamine | 1954 |
[Plasmodium berghei in mice; appearance of a state of immunity following repeated treatments with nivaquine during relapse].
Topics: Animals; Chloroquine; Chronic Disease; Immunity; Malaria; Mice; Plasmodium berghei; Quinolines; Recu | 1954 |
Modern Malaria Therapy and Prophylaxis.
Topics: Chloroquine; Malaria | 1954 |
[Malaria therapy with resochin in solution].
Topics: Chloroquine; Humans; Malaria | 1954 |
Potentiation of the curative action of primaquine in vivax malaria by quinine and chloroquine.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Vivax; Primaquine; Quinine | 1955 |
[Treatment of malaria with chloroquine (aralen)].
Topics: Chloroquine; Malaria | 1955 |
Potentialities of monthly doses of camoquin and a gametocidal drug in malaria control.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria | 1955 |
[Studies of the therapy of acute malarial attacks in Java, with special reference to resochin].
Topics: Chloroquine; Humans; Indonesia; Malaria; Social Behavior | 1955 |
Treatment on malaria with single doses of mepacrine, chloroquine and amodiaquin.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Quinacrine | 1955 |
[Field tests of chloroquin-table salt mixture].
Topics: Chloroquine; Humans; Malaria; Sodium Chloride; Sodium Chloride, Dietary | 1955 |
[Tests of chloroquine-table salt mixture in hospitalized patients].
Topics: Chloroquine; Humans; Malaria; Patients; Sodium Chloride; Sodium Chloride, Dietary | 1955 |
[Chloroquinated salt, new method of malaria prevention].
Topics: Chloroquine; Humans; Malaria; Sodium Chloride; Sodium Chloride, Dietary | 1955 |
[Research on the absorption and excretion of orally administered resochin (chloroquin) salts].
Topics: Biological Transport; Chloroquine; Malaria; Research; Salts | 1955 |
[Study of salt-chloroquine and follow-up program in hospitalized malaria patients].
Topics: Chloroquine; Follow-Up Studies; Humans; Malaria; Patients; Sodium Chloride; Sodium Chloride, Dietary | 1955 |
[Resochin prophylaxis in voyages in malaria-infested regions].
Topics: Chloroquine; Communicable Diseases; Humans; Malaria; Parasitic Diseases | 1956 |
[Improvement of a case of primary malaria with signs of myocardial infarct after nivaquine therapy].
Topics: Chloroquine; Malaria; Myocardial Infarction; Quinolines | 1956 |
Therapeutic response to single doses of chloroquine diphosphate in human malaria.
Topics: Chloroquine; Humans; Malaria | 1956 |
Therapeutic response to single doses of chloroquine diphosphate in human malaria.
Topics: Chloroquine; Humans; Malaria | 1956 |
Therapeutic response to single doses of chloroquine diphosphate in human malaria.
Topics: Chloroquine; Humans; Malaria | 1956 |
Therapeutic response to single doses of chloroquine diphosphate in human malaria.
Topics: Chloroquine; Humans; Malaria | 1956 |
Acquired resistance to chloroquine diphosphate in P. gallinaceum in chicks.
Topics: Animals; Chickens; Chloroquine; Malaria | 1956 |
Acquired resistance to chloroquine diphosphate in P. gallinaceum in chicks.
Topics: Animals; Chickens; Chloroquine; Malaria | 1956 |
Acquired resistance to chloroquine diphosphate in P. gallinaceum in chicks.
Topics: Animals; Chickens; Chloroquine; Malaria | 1956 |
Acquired resistance to chloroquine diphosphate in P. gallinaceum in chicks.
Topics: Animals; Chickens; Chloroquine; Malaria | 1956 |
Chloroquine naphthoate for malaria.
Topics: Child; Chloroquine; Humans; Infant; Malaria | 1957 |
[Eradication of malaria with chloroquine added to table salt].
Topics: Chloroquine; Humans; Malaria; Sodium Chloride, Dietary | 1956 |
Experiments with antimalarial drugs in man. VI. The value of chloroquine diphosphate as a suppressive drug in volunteers exposed to experimental mosquito-transmitted malaria; New Guinea strains.
Topics: Animals; Antimalarials; Chloroquine; Culicidae; Humans; Malaria; Male; New Guinea; Volunteers | 1957 |
Experiments with antimalarial drugs in man. VII. The suppressive effect of 50 MG. of chloroquine base daily in British troops exposed to infection with Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum | 1957 |
4-Aminoquinoline prophylaxis of malaria amongst semi-immune African school children.
Topics: Aminoquinolines; Antimalarials; Child; Chloroquine; Humans; Infant; Malaria | 1957 |
Comparative assessment of chloroquine and amodiaquine as malaria suppressives in Nigeria.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Nigeria | 1958 |
[Plasmodium berghei infection: immunological phenomena in infections made chronic with chloroquine].
Topics: Chloroquine; Malaria; Plasmodium berghei | 1957 |
[Experimental malaria: Plasmodium berghei].
Topics: Chloroquine; Malaria; Plasmodium berghei; Quinacrine; Quinine | 1958 |
Chloroquine or pyrimethamine in salt as a supressive against sporozoite-induced vivax malaria (Chesson strain).
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Vivax; Military Personnel; Pyrimetham | 1958 |
Chloroquine per rectum for malaria in children.
Topics: Administration, Rectal; Child; Chloroquine; Humans; Malaria; Rectum | 1959 |
[Experimental variations of the virulence of Plasmodium berghei; magnification; attenuation; mithridatism].
Topics: Chloroquine; Humans; Malaria; Plasmodium berghei; Virulence | 1959 |
Chloroquine treatment for malaria in semi-immune patients.
Topics: Chloroquine; Humans; Malaria | 1961 |
Single dose treatment of malaria with amodiaquin chloroquine and mepacrine in a semi-immune poplation.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Quinacrine | 1960 |
[The prophylaxis of malaria by addition of chloroquine and pyrimethamine to table salt].
Topics: Chloroquine; Diet; Humans; Malaria; Nutrition Assessment; Nutritional Status; Pyrimethamine; Sodium | 1960 |
Amodiaquine and hydroxychloroquine resistance in Plasmodium falciparum.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Hydroxychloroquine; Malaria; Plasmodium falciparum | 1961 |
Minimal single-dose subcutaneous chloroquine therapy of malaria in partly immune African pre-school children.
Topics: Child; Chloroquine; Humans; Malaria; Schools | 1961 |
Clinical features of overt vivax malaria seen in Australia: infections acquired in New Guinea.
Topics: Australia; Chloroquine; Humans; Malaria; Malaria, Vivax; New Guinea | 1959 |
A field test for the estimation of chloroquine in urine.
Topics: Antimalarials; Chloroquine; Insecticides; Malaria; Male; Regression Analysis | 1960 |
Mass treatment of malaria with chloroquine. Results of a trial in Inanwatan.
Topics: Chloroquine; Malaria | 1961 |
[Nil nocere'. Prolonged overdosage of chloroquine. Desirable and undesirable effects].
Topics: Chloroquine; Drug Overdose; Malaria; Motivation | 1962 |
[Resistance of P. falciparum to the action of chloroquine (preliminary note)].
Topics: Chloroquine; Humans; Malaria; Malaria, Falciparum | 1961 |
Nephrosis in Nigerian children. Role of Plasmodium malariae, and effect of antimalarial treatment.
Topics: Antimalarials; Child; Chloroquine; Humans; Malaria; Nephrotic Syndrome; Plasmodium malariae; Primaqu | 1963 |
Estivo-autumnal malaria in New York City. Diagnostic difficulties.
Topics: Chloroquine; Communicable Diseases; Hepatitis A; Humans; Malaria; New York City; Penicillins; Pneumo | 1963 |
Chloroquine-resistant falciparum malaria in Malaya.
Topics: Animals; Chloroquine; Culicidae; Humans; Malaria; Malaria, Falciparum; Malaysia | 1963 |
Studies on the toxicity and action of diaminodiphenyl-sulfone (DDS) in avian and simian malaria.
Topics: Animals; Antimalarials; Birds; Chloroquine; Dapsone; Malaria; Malaria, Avian; Proguanil; Pyrimethami | 1962 |
Radical cure of malaria and operational difficulties in its implementation.
Topics: Chloroquine; Humans; Malaria; Primaquine | 1962 |
Treatment of malaria with small daily doses of chloroquine hydroxynaphthoate or tannate.
Topics: Chloroquine; Humans; Malaria | 1963 |
PLASMODIUM MALARIAE IN UGANDAN CHILDREN. II. MALARIA PARASITES IN CHILDREN AT MULAGO HOSPITAL IN KAMPALA.
Topics: Animals; Black People; Child; Chloroquine; Epidemiology; Hospitals; Humans; Infant; Malaria; Parasit | 1963 |
CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM PORTO VELHO, BRAZIL.
Topics: Brazil; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1963 |
AEROMEDICAL ASPECTS OF MALARIA PROPHYLAXIS WITH CHLOROQUINE-PRIMAQUINE.
Topics: Aerospace Medicine; Anemia; Anemia, Hemolytic; Chloroquine; Humans; Malaria; Methemoglobinemia; Moto | 1963 |
BLACKWATER FEVER AFTER THE USE OF CHLOROQUINE-PYRIMETHAMINE.
Topics: Blackwater Fever; Chloroquine; Hemolysis; Humans; Malaria; New Guinea; Pyrimethamine; Quinine; Toxic | 1963 |
[LATENT VISCERAL MALARIA DUE TO PLASMODIUM VIVAX AMONG SOLDIERS DISCHARGED FROM THE FNA. APROPOS OF 2 CASES].
Topics: Chloroquine; Humans; Malaria; Military Personnel; Plasmodium vivax | 1963 |
A LONG-DELAYED PRIMARY ATTACK OF OVALE MALARIA.
Topics: Black People; Chloroquine; Humans; Malaria; Plasmodium | 1963 |
[MALARIA PREVENTION IN NEW GUINEA WITH DRUGS ADDED TO KITCHEN SALT].
Topics: Chloroquine; DDT; Humans; Malaria; Mosquito Control; New Guinea; Pyrimethamine; Sodium Chloride | 1963 |
CHLOROQUINE RESISTANT FALCIPARUM MALARIA IN MALAYA.
Topics: Animals; Chloroquine; Culicidae; Drug Resistance; Drug Resistance, Microbial; Humans; Malaria; Malar | 1963 |
DRUG-RESISTANT FALCIPARUM MALARIA FROM CAMBODIA AND MALAYA.
Topics: Animals; Cambodia; Chloroquine; Culicidae; Drug Resistance; Drug Resistance, Microbial; Humans; Mala | 1963 |
CONTROLLED TRIAL OF PYRIMETHAMINE IN PREGNANT WOMEN IN AN AFRICAN VILLAGE.
Topics: Birth Weight; Chloroquine; Female; Humans; Infant; Infant Mortality; Lactose; Malaria; Nigeria; Preg | 1964 |
STUDIES IN THE ACQUISITION OF IMMUNITY OF PLASMODIUM FALCIPARUM INFECTIONS IN AFRICA.
Topics: Adolescent; Africa; Africa, Western; Allergy and Immunology; Child; Chloroquine; Humans; Infant; Mal | 1964 |
THERAPEUTIC TRIALS OF CHLOROQUINE SILICATE IN TANGANYIKA.
Topics: Black People; Child; Chloroquine; Humans; Malaria; Silicates; Tanzania | 1964 |
FLUORESCENT ANTIBODY STUDIES IN HUMAN MALARIA. II. DEVELOPMENT AND PERSISTENCE OF ANTIBODIES TO PLASMODIUM FALCIPARUM.
Topics: Amodiaquine; Antibodies; Antigen-Antibody Reactions; Chloroquine; Fluorescent Antibody Technique; Hu | 1964 |
STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM THAILAND.
Topics: Amodiaquine; Antimalarials; Asia, Southeastern; Biomedical Research; Chloroquine; Drug Resistance; D | 1964 |
A MALARIA ERADICATION EXPERIMENT IN THE HIGHLANDS OF KIGEZI (UGANDA).
Topics: Chloroquine; DDT; Epidemiology; Humans; Malaria; Pyrimethamine; Uganda | 1964 |
MALARIA: AN UNSOLVED MILITARY MEDICAL PROBLEM.
Topics: Chloroquine; Epidemiology; Humans; International Agencies; International Cooperation; Malaria; Milit | 1964 |
[A PATIENT WITH TROPICAL MALARIA].
Topics: Amodiaquine; Antimalarials; Chloroquine; Dosage Forms; Drug Resistance; Drug Resistance, Microbial; | 1964 |
DRUG-RESISTANCE IN FALCIPARUM MALARIA IN SOUTH-EAST ASIA.
Topics: Adolescent; Asia, Southeastern; Child; Chloroquine; Drug Resistance; Drug Resistance, Microbial; Dru | 1964 |
ANTAGONISM OF THE ANTIMALARIAL ACTION OF CHLOROQUINE BY FERRIHEMATE AND AN HYPOTHESIS FOR THE MECHANISM OF CHLOROQUINE RESISTANCE.
Topics: Antimalarials; Chloroquine; Drug Tolerance; Heme; Malaria; Pharmacology; Rats; Research | 1964 |
[TROPICAL MALARIA. 2 CASES. DIAGNOSIS AND THERAPY].
Topics: Adolescent; Blood; Blood Transfusion; Chloroquine; Coombs Test; Diagnosis; Humans; Malaria; Norway; | 1964 |
CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN MALAYA.
Topics: Animals; Chloroquine; Culicidae; Drug Resistance; Drug Resistance, Microbial; Humans; Malaria; Malar | 1963 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
[CAMPAIGN AGAINST MALARIA WITH MEDICATED SALT IN NEW GUINEA].
Topics: Chloroquine; Humans; Malaria; New Guinea; Pharmacology; Pyrimethamine; Quinolines; Sodium Chloride | 1964 |
[TROPICAL MALARIA].
Topics: Blood; Blood Protein Electrophoresis; Chloroquine; Clinical Laboratory Techniques; Humans; Malaria; | 1964 |
COMPLEX FORMATION BETWEEN CHLOROQUINE AND FERRIHAEMIC ACID IN VITRO, AND ITS EFFECT ON THE ANTIMALARIAL ACTION OF CHLOROQUINE.
Topics: Animals; Antimalarials; Chloroquine; In Vitro Techniques; Iron; Malaria; Metabolism; Mice; Plasmodiu | 1964 |
CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN SOUTH-EAST ASIA, WITH A REPORT OF A CASE FROM THAILAND.
Topics: Asia, Southeastern; Chloroquine; Drug Resistance; Drug Resistance, Microbial; Humans; Malaria; Malar | 1964 |
ROLE OF P-AMINOBENZOIC ACID IN PLASMODIUM BERGHEI INFECTION IN THE MOUSE.
Topics: 4-Aminobenzoic Acid; Aminopterin; Animals; Chloroquine; Folic Acid; Folic Acid Deficiency; Leucovori | 1964 |
CHLOROQUINE SUICIDE.
Topics: Arthritis; Arthritis, Rheumatoid; Asia, Eastern; Chloroquine; Lupus Erythematosus, Discoid; Lupus Er | 1964 |
THE CONTROL OF EPIDEMIC MALARIA IN THE HIGHLANDS OF WESTERN KENYA. 3. AFTER THE CAMPAIGN.
Topics: Adolescent; Animals; Anopheles; Child; Chloroquine; Communicable Disease Control; Dieldrin; Drug The | 1964 |
THE USE OF MEDICATED SALT IN AN ANTIMALARIA CAMPAIGN IN WEST NEW GUINEA.
Topics: Antimalarials; Chloroquine; Epidemiology; Humans; Indonesia; Malaria; New Guinea; Pyrimethamine; Sod | 1964 |
[MALARIA, DIAGNOSIS AND TREATMENT].
Topics: Chloroquine; Diagnosis; Drug Therapy; Humans; Malaria; Quinolines | 1964 |
PIGMENT FORMATION AND NUCLEAR DIVISION IN CHLOROQUINE-RESISTANT MALARIA PARASITES (PLASMODIUM BERGHEI, VINCKE AND LIPS, 1948).
Topics: Animals; Blood Pressure; Cats; Cell Nucleus Division; Chloroquine; Epinephrine; Isoproterenol; Lip; | 1964 |
[ON THE DETECTION OF PLASMODIUM MALARIAE IN THE STERNAL MARROW].
Topics: Bone Marrow; Bone Marrow Examination; Chloroquine; Drug Therapy; Humans; Malaria; Plasmodium malaria | 1964 |
SYNOPTIC EPIDEMIOLOGICAL STUDIES OF MALARIA IN EL SALVADOR.
Topics: Adolescent; Central America; Child; Chloroquine; DDT; El Salvador; Epidemiologic Studies; Epidemiolo | 1965 |
APPARENT REFRACTORINESS TO CHLOROQUINE, PYRIMETHAMINE, AND QUININE IN STRAINS OF PLASMODIUM FALCIPARUM FROM VIETNAM.
Topics: Chloroquine; Drug Resistance; Drug Resistance, Microbial; Drug Therapy; Humans; Malaria; Military Me | 1965 |
MALARIA OCCURRING DURING THE PUERPERIUM AND IN THE NEONATE.
Topics: Chloroquine; Drug Therapy; Female; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Mal | 1965 |
STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM VIET-NAM.
Topics: Amodiaquine; Antimalarials; Biomedical Research; Chloroquine; Drug Therapy; Humans; Malaria; Malaria | 1964 |
SELECTION OF A STRAIN OF ALBINO MICE REFRACTORY TO PLASMODIUM BERGHEI INFECTION.
Topics: Animals; Antibodies; Chloroquine; Genetics; Immunity; Malaria; Mice; Plasmodium; Plasmodium berghei; | 1964 |
QUININE-RESISTANT PLASMODIUM BERGHEI IN MICE.
Topics: Animals; Chloroquine; Drug Resistance; Drug Resistance, Microbial; Malaria; Mice; Pharmacology; Plas | 1965 |
CHLOROQUINE-RESISTANT STRAIN OF PLASMODIUM FALCIPARUM FROM KHAO MAI KHAEO, THAILAND.
Topics: Chloroquine; Drug Resistance; Drug Resistance, Microbial; Drug Therapy; Humans; Malaria; Plasmodium | 1965 |
GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND FALCIPARUM MALARIA.
Topics: Biomedical Research; Chloroquine; Drug Therapy; Glucosephosphate Dehydrogenase Deficiency; Glucoseph | 1965 |
LATENT INFECTIONS WITH PLASMODIUM OVALE MALARIA.
Topics: Africa, Western; Aminoquinolines; Canada; Chloroquine; Communicable Diseases; Diagnosis; Drug Therap | 1965 |
MALARIA IN CHILDHOOD MODERN CONCEPTS OF IMMUNITY, TREATMENT, PROPHYLAXIS.
Topics: Amodiaquine; Child; Chloroquine; Diagnosis; Drug Therapy; Epidemiology; Humans; Infant; Infant, Newb | 1965 |
CHEMOPROPHYLAXIS OF HOMOZYGOUS SICKLERS WITH ANTIMALARIALS AND LONG-ACTING PENICILLIN.
Topics: Adolescent; Anemia; Anemia, Sickle Cell; Antimalarials; Biomedical Research; Chemoprevention; Child; | 1965 |
SOME FEATURES OF MALARIA IN DILI, PORTUGUESE TIMOR, DURING 1963-64.
Topics: Amodiaquine; Anemia; Chloroquine; Clinical Laboratory Techniques; Drug Therapy; Epidemiology; Humans | 1965 |
Field trials of nivaquine, camoquin and resochin against human malaria.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria; Quinolines; Uricosuric Agents | 1954 |
Studies on the chemotherapy of malaria. III. The treatment of acute malaria with chloroquine.
Topics: Chloroquine; Malaria | 1954 |
[Diagnostic difficulties in malaria outbreaks under chloroquine protection in not immune individuals in Liberia].
Topics: Chloroquine; Disease Outbreaks; Humans; Liberia; Malaria | 1954 |
The treatment of malaria with hydroxychloroquine.
Topics: Chloroquine; Hydroxychloroquine; Malaria | 1955 |
The single dose treatment of falciparum malaria with nivaquine; a review of 164 cases treated at the District Hospital, Kuala Kangsar.
Topics: Chloroquine; Hospitals, District; Malaria; Malaria, Falciparum; Quinolines; Uricosuric Agents | 1955 |
The addition of antimalarial drugs to cooking salt: its importance in malaria eradication programmes.
Topics: Antimalarials; Chloroquine; Cooking; Humans; Malaria; Sodium Chloride; Sodium Chloride, Dietary | 1959 |
Mass suppression of hyperendemic vivax malaria with hydroxychloroquine.
Topics: Chloroquine; Humans; Hydroxychloroquine; Malaria; Malaria, Vivax | 1960 |
[Cases of malaria caused by Plasmodium falciparum resistant to treatment with chloroquine].
Topics: Chloroquine; Humans; Malaria; Medical Records; Plasmodium falciparum | 1961 |
The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy.
Topics: Africa, Eastern; Amodiaquine; Antimalarials; Chloroquine; Disease Susceptibility; Drug Combinations; | 2003 |
Home treatment of 'malaria' in children in rural Gambia is uncommon.
Topics: Adult; Aged; Antimalarials; Caregivers; Child; Chloroquine; Female; Gambia; Health Expenditures; Hom | 2003 |
Two worlds of malaria.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Life Cycle St | 2003 |
Delayed onset of malaria--implications for chemoprophylaxis in travelers.
Topics: Antimalarials; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Israel; Malaria; Malaria, Fal | 2003 |
Diagnosis and treatment of malaria in children.
Topics: Animals; Antimalarials; Atovaquone; Child; Chloroquine; Drug Combinations; Humans; Malaria; Malaria, | 2003 |
Malaria researchers say global fund is buying "useless drug".
Topics: Antimalarials; Chloroquine; Humans; Malaria | 2003 |
Sex ratios in the rodent malaria parasite, Plasmodium chabaudi.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Female; Malaria; Male; Mice; Mice, Inbr | 2003 |
Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice.
Topics: Animals; Antimalarials; Chloroquine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Co | 2003 |
Which children come to the health centre for treatment of malaria?
Topics: Adolescent; Antimalarials; Case-Control Studies; Child; Child Health Services; Child, Preschool; Chl | 2004 |
Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment.
Topics: Animals; Antimalarials; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chloroquine; Female; | 2004 |
Interaction between chloroquine sulphate and aqueous extract of Azadirachta indica A. Juss (Meliaceae) in rabbits.
Topics: Administration, Oral; Animals; Azadirachta; Chloroquine; Drug Combinations; Drug Interactions; Half- | 2003 |
[Therapeutic effect of sontoquine (nivaquine) in malaria].
Topics: Chloroquine; Humans; Malaria | 1951 |
A study of the prophylactic value of chloroquine in children.
Topics: Child; Chloroquine; Humans; Malaria | 1951 |
[Treatment of tertian malaria with nivaquine-plasmochine].
Topics: Chloroquine; Humans; Malaria | 1951 |
Evaluation of synthetic anti-malarial drugs in children from a hyperendemic area in West Africa.
Topics: Africa, Western; Antimalarials; Child; Chloroquine; Humans; Malaria; Quinacrine | 1951 |
[Massive doses and chloroquine therapy of malaria].
Topics: Chloroquine; Humans; Malaria | 1951 |
Response of Plasmodium malariae infections to three different drugs; response to metachloridine, chloroguanide (paludrine), and intramuscular chloroquine.
Topics: Chloroquine; Humans; Injections, Intramuscular; Malaria; Plasmodium malariae; Proguanil; Sulfonamide | 1951 |
Field trial of chloroquine (SN-7618-5) for malaria control in central Taiwan (Formosa).
Topics: Chloroquine; Malaria; Taiwan | 1950 |
The prophylaxis of malaria and amebiasis with milibis-aralen.
Topics: Amebiasis; Arsenicals; Bismuth; Chloroquine; Dysentery, Amebic; Malaria | 1952 |
[Treatment of malaria in infants and children with nivaquine].
Topics: Child; Chloroquine; Humans; Infant; Malaria | 1951 |
Chloroquine as a malarial prophylactic in indigenous children of Central Africa.
Topics: Africa, Central; Child; Chloroquine; Humans; Malaria | 1951 |
Failure to produce resistance to chloroquine in Plasmodium gallinaceum in chicks.
Topics: Animals; Chickens; Chloroquine; Humans; Malaria; Plasmodium; Plasmodium gallinaceum | 1952 |
[Treatment of tropical malaria in equatorial west Africa with resochin].
Topics: Africa, Western; Chloroquine; Humans; Malaria | 1951 |
Malaria treated successfully with resochin.
Topics: Chloroquine; Malaria; Quinolines; Uricosuric Agents | 1952 |
Treatment of malaria with a single dose of amodiaquine or chloroquine.
Topics: Amodiaquine; Chloroquine; Humans; Malaria | 1952 |
Hypothesis links emergence of chloroquine-resistant malaria and other intracellular pathogens and suggests a new strategy for treatment of diseases caused by intracellular parasites.
Topics: Acquired Immunodeficiency Syndrome; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria | 2004 |
Synergistic interaction of a chloroquine metabolite with chloroquine against drug-resistant malaria parasites.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Interactions; Drug Resistance; Drug Syner | 2004 |
Certain red cell genetic factors and prevalence of chloroquine-induced pruritus.
Topics: Adolescent; Adult; Antimalarials; Biomarkers; Child; Child, Preschool; Chloroquine; Erythrocytes; Fe | 2002 |
A large focus of naturally acquired Plasmodium knowlesi infections in human beings.
Topics: Adult; Animals; Chloroquine; DNA, Protozoan; Erythrocytes; Humans; Macaca; Malaria; Malaysia; Monkey | 2004 |
WHO, the Global Fund, and medical malpractice in malaria treatment.
Topics: Altruism; Antimalarials; Chloroquine; Drug Costs; Financing, Organized; Global Health; Humans; Inter | 2004 |
Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Fol | 2004 |
Ghana battles drug-resistant malaria with artesunate.
Topics: Antimalarials; Artemisinins; Artesunate; Child, Preschool; Chloroquine; Drug Resistance; Ghana; Huma | 2004 |
Is the expression of genes encoding enzymes of glutathione (GSH) metabolism involved in chloroquine resistance in Plasmodium chabaudi parasites?
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Glutamate-Cysteine Ligase; Glutathione; Glutat | 2004 |
Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria.
Topics: Adolescent; Anemia, Sickle Cell; Antimalarials; Bilirubin; Child; Child, Preschool; Chloroquine; Fem | 2004 |
Retail supply of malaria-related drugs in rural Tanzania: risks and opportunities.
Topics: Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antimalarials; Chloroquine; Commerce; Dosage Forms; | 2004 |
Increased parasitaemia and delayed parasite clearance in Schistosoma mansoni and Plasmodium berghei co-infected mice.
Topics: Animals; Antimalarials; Chloroquine; Malaria; Male; Mice; Parasitemia; Plasmodium berghei; Random Al | 2004 |
Antimalarial activities of Tithonia diversifolia (Asteraceae) and Crossopteryx febrifuga (Rubiaceae) on mice in vivo.
Topics: Administration, Oral; Animals; Antimalarials; Asteraceae; Chloroquine; Dose-Response Relationship, D | 2004 |
Community chloroquine distribution for malaria control in Bushenyi district of Uganda.
Topics: Adult; Antimalarials; Chloroquine; Cross-Sectional Studies; Female; Health Knowledge, Attitudes, Pra | 2003 |
Effects of autacoid inhibitors and of an antagonist on malaria infection in mice.
Topics: Animals; Antimalarials; Autacoids; Chloroquine; Cyproheptadine; Drug Combinations; Fenclonine; Hista | 2004 |
Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin.
Topics: Animals; Antimalarials; Artemisinins; Carbon Monoxide; Chloroquine; Erythrocytes; Heme; Hemoglobins; | 2004 |
Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes.
Topics: Alleles; Animals; Anopheles; Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; Chloroq | 2004 |
Treatment of malaria in children with chloroquine.
Topics: Child; Chloroquine; Humans; Malaria | 1950 |
Chloroquine, proguanil, mepacrine and quinine in the treatment of malaria caused by Plasmodium falciparum.
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum; Proguanil; Quinacrine; Quinine | 1949 |
[Observations on the treatment of malaria with chloroquine in Porto Velho, Guaporé].
Topics: Chloroquine; Humans; Malaria | 1950 |
Single intravenous injections of chloroquine in the treatment of falciparum malaria: toxic and immediate therapeutic effects in 110 cases.
Topics: Chloroquine; Humans; Injections, Intravenous; Malaria; Malaria, Falciparum | 1950 |
[Aralen and paludrine antimalarial prophylaxis in the rural regions].
Topics: Antimalarials; Chloroquine; Humans; Malaria; Proguanil; Rural Population | 1950 |
Plasmodium berghei: dehydroepiandrosterone sulfate reverses chloroquino-resistance in experimental malaria infection; correlation with glucose 6-phosphate dehydrogenase and glutathione synthesis pathway.
Topics: Animals; Antimalarials; Chloroquine; Dehydroepiandrosterone Sulfate; Drug Interactions; Drug Resista | 2004 |
Plasmodium berghei: efficacy and safety of combinations of chloroquine and promethazine in chloroquine resistant infections in gravid mice.
Topics: Animals; Antimalarials; Birth Weight; Chloroquine; Drug Resistance; Drug Therapy, Combination; Femal | 2004 |
Rifampicin antagonizes the effect of choloroquine on chloroquine-resistant Plasmodium berghei in mice.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Malaria; Mice; Para | 2004 |
Antimalarial drug use among caregivers in Ghana.
Topics: Adolescent; Adult; Aged; Antimalarials; Caregivers; Chloroquine; Clinical Competence; Drug Storage; | 2004 |
An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi.
Topics: Alleles; Animals; Chloroquine; Chromosome Mapping; Chromosomes; Disease Models, Animal; DNA, Protozo | 2005 |
Design and synthesis of new antimalarial agents from 4-aminoquinoline.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Design; Drug Resistance; Hemin; Malaria; | 2005 |
[Assessment of chloroquine resistance two years after stopping chemoprophylaxis in 0 to 9-year-old children living in a malaria-endemic village of Mali].
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Studies; Endemic Disea | 2004 |
[Barriers in the community management of child malaria in the city of Mékhé (Senegal)].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Child, Preschool; Chloroquine; Community | 2002 |
Pretreatment blood concentrations of chloroquine in patients with malaria infection: relation to response to treatment.
Topics: Administration, Oral; Antimalarials; Child; Child, Preschool; Chloroquine; Cohort Studies; Confidenc | 2005 |
Prophylaxis against rabies.
Topics: Animals; Antibodies, Viral; Bites and Stings; Chloroquine; Drug Interactions; Endemic Diseases; Huma | 2005 |
Neurotoxicity due to antimalarial therapy associated with misdiagnosis of malaria.
Topics: Adult; Antimalarials; Anxiety; Artemisinins; Artesunate; Ataxia; Chloroquine; Diagnostic Errors; Hum | 2005 |
Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites.
Topics: Animals; Antimalarials; Bridged Bicyclo Compounds, Heterocyclic; Chloroquine; Drug Resistance; Drug | 2005 |
Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in Central African children with noncomplicated malaria.
Topics: Amodiaquine; Antimalarials; Central African Republic; Child, Preschool; Chloroquine; Drug Combinatio | 2005 |
Plasmodium berghei NK65: studies on the effect of treatment duration and inoculum size on recrudescence.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Erythrocytes; Female; Lethal | 2005 |
The pattern of home treatment of malaria in under-fives in south eastern Nigeria.
Topics: Adult; Antimalarials; Child, Preschool; Chloroquine; Cross-Sectional Studies; Drug Combinations; Fem | 2005 |
Making antimalarial agents available in Africa.
Topics: Africa; Antimalarials; Artemisinins; Chloroquine; Delivery of Health Care; Drug Costs; Drug Resistan | 2005 |
Effectiveness of antimalarial drugs.
Topics: Africa; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria; Pyrimethami | 2005 |
Analysis of immune response patterns in naïve and Plasmodium berghei-infected young rats following a ferroquine treatment.
Topics: Aminoquinolines; Animals; Antibodies, Protozoan; Antimalarials; Cell Proliferation; Cells, Cultured; | 2005 |
Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Female; Ghana; Humans; Infan | 2005 |
Treatment of paediatric malaria during a period of drug transition to artemether-lumefantrine in Zambia: cross sectional study.
Topics: Ambulatory Care; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Chlo | 2005 |
Imported malaria in pregnancy: a retrospective study of 18 cases in Marseilles, France.
Topics: Adolescent; Adult; Anemia; Antimalarials; Chloroquine; Female; France; Humans; Hypoglycemia; Malaria | 2005 |
[Malaria prophylaxis for long-term travellers and expatriates].
Topics: Antimalarials; Atovaquone; Chloroquine; Counseling; Doxycycline; Drug Combinations; Humans; Insect B | 2005 |
Current status and evolution of antimalarial drug resistance (with special reference to chloroquine and related blood schizontocides).
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Malaria; Plasmodium | 1989 |
Factors contributing to the development of anaemia in Plasmodium falciparum malaria: what about drug-resistant parasites?
Topics: Amodiaquine; Anemia; Animals; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug R | 2006 |
Self-medication with chloroquine in a rural district of Tanzania: a therapeutic challenge for any future malaria treatment policy change in the country.
Topics: Antimalarials; Child, Preschool; Chloroquine; Female; Health Education; Humans; Infant; Infant, Newb | 2005 |
How sulfadoxine-pyrimethamine (SP) was perceived in some rural communities after phasing out chloroquine (CQ) as a first-line drug for uncomplicated malaria in Tanzania: lessons to learn towards moving from monotherapy to fixed combination therapy.
Topics: Antimalarials; Attitude to Health; Chloroquine; Drug Combinations; Drug Therapy, Combination; Focus | 2006 |
In vitro susceptibility and genetic variations for chloroquine and mefloquine in Plasmodium falciparum isolates from Thai-Myanmar border.
Topics: Animals; Chloroquine; Disease Susceptibility; Drug Resistance, Microbial; Genetic Variation; Humans; | 2005 |
[Congenital malaria as a result of Plasmodium malariae in an infant born to a HIV-seropositive woman].
Topics: Antimalarials; Chloroquine; France; HIV Infections; Humans; Infant; Infectious Disease Transmission, | 2005 |
Plasmodium berghei: development of an irreversible experimental malaria model in Wistar rats.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Erythrocytes; Malaria; Parasitemia; Pla | 2006 |
Can malaria be controlled where basic health services are not used?
Topics: Africa; Antimalarials; Chloroquine; Home Nursing; Hospitalization; Humans; Malaria; Mali; Patient Ac | 2006 |
Epidemiology of malaria in New Halfa, an irrigated area in eastern Sudan.
Topics: Adolescent; Adult; Age Distribution; Agriculture; Antimalarials; Child; Child, Preschool; Chloroquin | 2005 |
[Self-treatment of fever in the northern district of Dakar, Senegal].
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Studies; Dru | 2006 |
A steep decline of malaria morbidity and mortality trends in Eritrea between 2000 and 2004: the effect of combination of control methods.
Topics: Adult; Antimalarials; Bedding and Linens; Child; Chloroquine; DDT; Drug Combinations; Drug Resistanc | 2006 |
Adherence of community caretakers of children to pre-packaged antimalarial medicines (HOMAPAK) among internally displaced people in Gulu district, Uganda.
Topics: Adult; Antimalarials; Caregivers; Child, Preschool; Chloroquine; Drug Combinations; Drug Packaging; | 2006 |
Update on hypothesis linking chloroquine-resistant malaria to disease-causing HIV.
Topics: Antimalarials; Chloroquine; Drug Resistance; HIV; HIV Infections; Humans; Malaria; Models, Biologica | 2006 |
Factors associated with malaria treatment failures in Ibadan.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Health Behavior; Hum | 2005 |
Chloroquine efficacy in Plasmodium berghei NK65-infected ICR mice, with reference to the influence of initial parasite load and starting day of drug administration on the outcome of treatment.
Topics: Animals; Antitubercular Agents; Chloroquine; Drug Administration Schedule; Malaria; Male; Mice; Mice | 2006 |
Impact of chloroquine on viral load in breast milk.
Topics: Adult; Anti-HIV Agents; Antimalarials; Breast Feeding; CD4 Lymphocyte Count; Chloroquine; Drug Combi | 2006 |
Frequency of malaria and glucose-6-phosphate dehydrogenase deficiency in Tajikistan.
Topics: Adult; Chloroquine; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria; Malaria, Vivax; Mal | 2006 |
A survey of anti-malarial activity during pregnancy, and children's malaria care-seeking behaviour in two Nigerian rural communities.
Topics: Antimalarials; Bedding and Linens; Child, Preschool; Chloroquine; Developing Countries; Female; Huma | 2006 |
The World Bank: false financial and statistical accounts and medical malpractice in malaria treatment.
Topics: Africa; Antimalarials; Brazil; Chloroquine; Financing, Organized; Humans; India; Malaria; Malpractic | 2006 |
The Booster Program for Malaria Control: putting knowledge and money to work.
Topics: Africa; Antimalarials; Child; Chloroquine; Financing, Organized; Humans; India; Malaria; United Nati | 2006 |
Methodological issues in the assessment of antimalarial drug treatment: analysis of 13 studies in eight African countries from 2001 to 2004.
Topics: Africa; Amodiaquine; Antimalarials; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug Co | 2006 |
Epidemiology of malaria in infancy at Enugu, Nigeria.
Topics: Age Factors; Antimalarials; Chloroquine; Female; Humans; Incidence; Infant; Infant, Newborn; Malaria | 2006 |
Report of a case of congenital malaria Plasmodium malariae in France.
Topics: Adult; Animals; Antimalarials; Chloroquine; Female; France; HIV Infections; Humans; Infant; Infectio | 2006 |
Vangueria infausta root bark: in vivo and in vitro antiplasmodial activity.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Malaria; Malaria, Falciparum; Mice; Mice, Inbr | 2006 |
Assessment of quality of chloroquine tablets sold by drug vendors in Abeokuta, Nigeria.
Topics: Adolescent; Adult; Antimalarials; Chemistry, Pharmaceutical; Child; Chloroquine; Commerce; Education | 2006 |
Malaria--time to act.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Endemic Diseases; History, 20th Century; Human | 2006 |
Malaria. Chloroquine makes a comeback.
Topics: Adult; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malar | 2006 |
Treating malaria at home in Uganda.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Caregivers; Chloroquine; Dev | 2006 |
Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Synergism; Kenya; Malaria; Medicine, Trad | 2007 |
Plasmodium ovale--a case report from Gujarat.
Topics: Adult; Animals; Antimalarials; Chloroquine; Humans; India; Malaria; Male; Plasmodium ovale; Treatmen | 2006 |
Pre-hospital treatment of febrile illness in children attending the General Outpatients Clinic, University College Hospital, Ibadan, Nigeria.
Topics: Ambulatory Care Facilities; Antimalarials; Child; Child Care; Child, Preschool; Chloroquine; Cross-S | 2006 |
Immunomodulatory role of chloroquine and pyrimethamine in Plasmodium yoelii 17XL infected mice.
Topics: Animals; Apoptosis; Chloroquine; Cytokines; Immunologic Factors; Malaria; Mice; Mice, Inbred BALB C; | 2007 |
In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Drug Synergism; Kenya; Malaria; Mal | 2007 |
Evaluation of antiplasmodial activity of ethanolic seed extract of Picralima nitida.
Topics: Animals; Antimalarials; Apocynaceae; Chloroquine; Dose-Response Relationship, Drug; Female; Lethal D | 2007 |
Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Femal | 2007 |
Home-based management of fever in rural Uganda: community perceptions and provider opinions.
Topics: Adolescent; Adult; Antimalarials; Child, Preschool; Chloroquine; Community Health Services; Communit | 2007 |
The role of communication between clients and health care providers: implications for adherence to malaria treatment in rural Gambia.
Topics: Antimalarials; Attitude to Health; Child; Child, Preschool; Chloroquine; Communication Barriers; Dru | 2007 |
Malaria parasite induces tryptophan-related immune suppression in mice.
Topics: Animals; Antimalarials; CD4-Positive T-Lymphocytes; Chloroquine; Enzyme Activation; Enzyme Inhibitor | 2007 |
Antimalarial properties of Goniothalamin in combination with chloroquine against Plasmodium yoelii and Plasmodium berghei growth in mice.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ma | 2006 |
Operational feasibility of rapid diagnostic kits & blister packs use for malaria control in high transmission areas of Orissa & Chhattisgarh.
Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Communicable Disease Control; Cross-Sectional S | 2007 |
Plasmodium yoelii: influence of antimalarial treatment on acquisition of immunity in BALB/c and DBA/2 mice.
Topics: Animals; Antibodies, Protozoan; Antimalarials; Artemisinins; Artesunate; Chloroquine; Female; Immuno | 2007 |
Can weekly home visits and treatment by non-medical personnel reduce malaria-related mortality among children under age 5 years?
Topics: Antimalarials; Burkina Faso; Child, Preschool; Chloroquine; Cohort Studies; Female; Home Nursing; Hu | 2007 |
Assessing malaria burden during pregnancy in Mali.
Topics: Adult; Animals; Antimalarials; Chloroquine; Cross-Sectional Studies; Drug Combinations; Female; Huma | 2007 |
Effect of meteorological factors on clinical malaria risk among children: an assessment using village-based meteorological stations and community-based parasitological survey.
Topics: Animals; Anopheles; Burkina Faso; Child, Preschool; Chloroquine; Cluster Analysis; Female; Greenhous | 2007 |
Effect of chloroquine on gene expression of Plasmodium yoelii nigeriensis during its sporogonic development in the mosquito vector.
Topics: Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Culicidae; Female; Gene Expression; Gene E | 2007 |
Estimating antimalarial drugs consumption in Africa before the switch to artemisinin-based combination therapies (ACTs).
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Therapy; Drug Therapy, Combination; Humans; Malaria; | 2007 |
Battling the malaria iceberg with chloroquine in India.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Delivery of Health Care; Drug Combinations; Dr | 2007 |
Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Design; | 2007 |
Health workers perceptions on chloroquine and sulfadoxine/sulfalene pyrimethamine monotherapies: implications for the change to combination therapy of artemether/lumefantrine in Tanzania.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Attitude of Health Pe | 2007 |
The response of students to malaria and malaria therapy in a university in southwest Nigeria.
Topics: Adult; Antimalarials; Chloroquine; Dosage Forms; Female; Health Knowledge, Attitudes, Practice; Huma | 2007 |
Clinical inquiries. When should travelers begin malaria prophylaxis?
Topics: Antimalarials; Chloroquine; Contraindications; Doxycycline; Humans; Insect Repellents; Insecticides; | 2007 |
Apparent relapse of imported Plasmodium ovale malaria in a pregnant woman.
Topics: Adult; Animals; Antimalarials; Chloroquine; Female; Humans; Malaria; Plasmodium ovale; Pregnancy; Pr | 2007 |
[Is chloroquine back?].
Topics: Antimalarials; Chloroquine; Clinical Trials as Topic; Humans; Malaria; Malawi | 2007 |
The risk of antimalarials in patients with renal failure.
Topics: Adult; Anemia, Megaloblastic; Antimalarials; Chloroquine; Dermatitis, Exfoliative; Drug Therapy, Com | 2007 |
Studies in human malaria; the protective and therapeutic action of chloroquine (SN 7618) against St. Elizabeth strain vivax malaria.
Topics: Chloroquine; Humans; Malaria; Malaria, Vivax; Sprains and Strains | 1949 |
Studies in human malaria; the intramuscular administration of chloroquine.
Topics: Chloroquine; Humans; Injections, Intramuscular; Malaria | 1948 |
A second year's field trial with chloroquine suppression of high endemic malaria in a Panamanian village.
Topics: Chloroquine; Humans; Malaria; Quinolines | 1949 |
The effect of chloroquine diphosphate on malaria splenomegaly.
Topics: Chloroquine; Malaria; Splenomegaly | 1949 |
Parasites and progress: ethical decision-making and the Santee-Cooper Malaria study, 1944-1949.
Topics: Animals; Anopheles; Child; Chloroquine; DDT; Ethics, Research; History, 20th Century; Humans; Insect | 2008 |
Assessment of a treatment guideline to improve home management of malaria in children in rural south-west Nigeria.
Topics: Caregivers; Child; Chloroquine; Female; Health Knowledge, Attitudes, Practice; Home Nursing; Humans; | 2008 |
From chloroquine to artemether-lumefantrine: the process of drug policy change in Zambia.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Therapy, Combination; Ethanolamines; Fluorenes; Healt | 2008 |
Malaria control in South Africa - challenges and successes.
Topics: Anti-Infective Agents; Antimalarials; Artemisinins; Chloroquine; History, 19th Century; History, 20t | 2007 |
A simple technique for the detection of anti-malarial drug formulations and their presence in human urine.
Topics: Amodiaquine; Antimalarials; Biological Assay; Biological Availability; Chloroquine; Chromatography, | 2006 |
Pharmacokinetic determinants of the window of selection for antimalarial drug resistance.
Topics: Algorithms; Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Computer Simulation; Dru | 2008 |
Malaria in Egypt, Saudi Arabia and Yemen: a clinical pilot study.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Artemether; Artemisinins; Child; Child, Preschool; | 2007 |
Acute renal failure in Plasmodium malariae infection.
Topics: Acute Kidney Injury; Adult; Animals; Antimalarials; Chloroquine; Female; Humans; Liver Failure; Mala | 2008 |
Antiplasmodial activity of sesquiterpene lactone from Carpesium rosulatum in mice.
Topics: Animals; Animals, Outbred Strains; Antimalarials; Asteraceae; Chloroquine; Malaria; Male; Mice; Mice | 2008 |
Iron incorporation and post-malaria anaemia.
Topics: Anemia; Antimalarials; Child, Preschool; Chloroquine; Dietary Supplements; Erythrocytes; Gambia; Hem | 2008 |
Treatment of chloroquine-resistant Plasmodium falciparum infections in Vietnam.
Topics: Chloroquine; Dapsone; Humans; Malaria; Military Medicine; Pyrimethamine; Quinacrine; Quinine; Sulfad | 1967 |
Malaria prophylaxis and treatment in G-6-PD deficiency. An observation on the toxicity of primaquine and chloroquine.
Topics: Adult; Child; Child, Preschool; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficiency; Hema | 1967 |
Activity of chloroquine against Plasmodium berghei in mice both with and without previous exposure to chloroquine.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Malaria; Mice | 1967 |
Napthoquinone antimalarials. XXX. 2-hydroxy-3-[omega-(1-adamantyl)alkyl]-1,4-naphthoquinones.
Topics: Animals; Antimalarials; Chemistry, Organic; Chloroquine; Malaria; Mice; Naphthoquinones; Organic Che | 1967 |
Potential antimalarial compounds. IX. Pyrimidine derivatives of urea and guanidine.
Topics: Animals; Antimalarials; Chemistry, Organic; Chloroquine; Guanidines; Malaria; Mice; Organic Chemistr | 1967 |
Malarial transfusions.
Topics: Blood Transfusion; Carrier State; Chloroquine; Drug Resistance, Microbial; Humans; Malaria | 1967 |
[Diagnostic and therapeutic problems in our tropical malaria cases].
Topics: Adult; Chloroquine; Female; Humans; Hungary; Malaria; Male | 1967 |
Sequestration of schizonts in the deep tissues of mice infected with chloroquine-resistant Plasmodium berghei.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Malaria; Mice; Plasmodium | 1967 |
Chemotherapy of sporozoite- and blood-induced Plasmodium berghei infections with selected antimalarial agents.
Topics: Animals; Chloroquine; Cricetinae; Dapsone; Malaria; Mice; Primaquine; Pyrimethamine; Quinine; Rats | 1967 |
An outbreak of malaria on shipboard.
Topics: Adolescent; Adult; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Quinine; Ships | 1967 |
Loss of chloroquine resistance on transfer of Plasmodium berghei from mouse to hamster.
Topics: Animals; Chloroquine; Cricetinae; Drug Tolerance; Malaria; Mice; Pigmentation; Plasmodium | 1967 |
Chloroquine-resistant falciparum malaria.
Topics: Chloroquine; Diagnosis, Differential; Drug Resistance, Microbial; Humans; Malaria; Military Medicine | 1967 |
Malaria cases up; current treatment suggestions offered.
Topics: Chloroquine; Humans; Malaria; Primaquine | 1967 |
Erythrocyte membrane-bound enzymes in Mastomys natalensis during Plasmodium berghei infection.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetylcholinesterase; Acetylglucosaminidase; Acid Phosphatase; | 1984 |
Tolerance and haematological findings with antimalarials (chloroquine and Fansidar [pyrimethamine plus sulfadoxine]) in adults and children during field trials in Nigeria.
Topics: Adult; Child; Chloroquine; Drug Combinations; Drug Tolerance; Female; Hemoglobinometry; Humans; Leuk | 1980 |
Single dose therapy with a combination of chloroquine and pyrimethamine (darachlor) in the treatment of malaria. Short communication.
Topics: Administration, Oral; Adult; Child, Preschool; Chloroquine; Drug Therapy, Combination; Humans; Malar | 1981 |
Malaria prophylaxis when visiting areas of East Africa with chloroquine resistance.
Topics: Africa, Eastern; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum; Travel | 1981 |
Malaria prophylaxis in areas of chloroquine resistance.
Topics: Africa, Eastern; Chloroquine; Humans; Malaria; Plasmodium falciparum | 1981 |
Malaria prophylaxis with chloroquine.
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum | 1981 |
Malaria prophylaxis with chloroquine.
Topics: Chloroquine; Diarrhea; Humans; Malaria; Vomiting | 1981 |
Malaria prophylaxis with chloroquine.
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum | 1981 |
Chloroquine-resistant falciparum malaria in semi-immune African Tanzaniana.
Topics: Adult; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum; Tanzania | 1982 |
Possible role of drug malabsorption in recrudescence of falciparum malaria.
Topics: Chloroquine; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Recurrence; United Kingdom; | 1982 |
Antimalarial activity of inhibitors of ADP-ribosyl transferase against Plasmodium yoelii infection in mice. 1. Preliminary data.
Topics: Animals; Antimalarials; Benzamides; Chloroquine; Drug Evaluation, Preclinical; Malaria; Male; Mice; | 1982 |
Quinine in chloroquine-resistant falciparum malaria.
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum; Quinine; Tissue Distribution | 1983 |
Why not proguanil in malaria prophylaxis?
Topics: Chloroquine; Malaria; Plasmodium falciparum; Proguanil | 1983 |
Possible case of RIII chloroquine-resistant malaria from East Africa.
Topics: Africa, Eastern; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Female; Humans; Malaria; Mid | 1983 |
Proguanil for malaria prophylaxis.
Topics: Adolescent; Africa; Child; Chloroquine; Humans; Malaria; Proguanil | 1983 |
Malaria control and primary health care.
Topics: Africa; Child; Chloroquine; Humans; Malaria; Plasmodium falciparum | 1983 |
Failure of chloroquine prophylaxis in Plasmodium falciparum in Zaire.
Topics: Chloroquine; Democratic Republic of the Congo; Humans; Malaria; Plasmodium falciparum; United States | 1983 |
Changes in malaria incidence after mass drug administration in Nicaragua.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Health Education; Humans; Infant; M | 1983 |
Mass drug administration for control of malaria.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Nicaragua; Primaquine | 1983 |
Malaria control and primary health care.
Topics: Amodiaquine; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Papua New Guinea; Plasmodium | 1983 |
Prolonged incubation improves the micro-scale in-vitro test for drug sensitivity of Plasmodium falciparum.
Topics: Adolescent; Adult; Antimalarials; Blood; Child; Child, Preschool; Chloroquine; Culture Media; Drug R | 1984 |
Failure of chloroquine-erythromycin and chloroquine-tetracycline combinations in treatment of chloroquine-resistant falciparum malaria in eastern Thailand.
Topics: Adolescent; Adult; Child; Chloroquine; Drug Resistance; Drug Therapy, Combination; Erythromycin; Fem | 1984 |
Serum chloroquine levels in children before treatment for malaria.
Topics: Child; Chloroquine; Ghana; Humans; Malaria; Plasmodium | 1984 |
Amodiaquine and chloroquine efficacy against Plasmodium falciparum in Madagascar.
Topics: Amodiaquine; Chloroquine; Humans; Madagascar; Malaria; Plasmodium falciparum | 1984 |
Chloroquine prophylaxis associated with a poor antibody response to human diploid cell rabies vaccine.
Topics: Antibodies, Viral; Chloroquine; Humans; Malaria; Rabies Vaccines; Rabies virus | 1984 |
Chloroquine-resistant Plasmodium falciparum malaria from Angola.
Topics: Adult; Angola; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum | 1984 |
Chloroquine resistant Plasmodium falciparum malaria in Namibia.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Namibia; Plasmodium falciparum | 1984 |
Intramuscular chloroquine in children.
Topics: Animals; Child; Chloroquine; Humans; Injections, Intramuscular; Malaria; Rabbits | 1984 |
Chloroquine prophylaxis and antibody response to immunisation.
Topics: Antibody Formation; Chloroquine; Humans; Immunization; Infant; Malaria; Measles; Polysaccharides, Ba | 1984 |
Chemoprophylaxis of malaria in non-immune residents in Dar es Salaam, Tanzania.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Administ | 1984 |
Malaria control in Tanzania.
Topics: Child; Chloroquine; Humans; Malaria; Tanzania | 1984 |
Chloroquine-resistant malaria in Pakistan.
Topics: Adult; Chloroquine; Drug Resistance; Humans; Malaria; Male; Pakistan; Plasmodium falciparum; United | 1984 |
Chloroquine-resistant malaria in India.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; India; Malaria; Male; Middle Aged; Plasmodium falci | 1984 |
Chloroquine-associated pruritus in a European.
Topics: Adult; Chloroquine; Drug Eruptions; Female; Humans; Kenya; Malaria; Pruritus; White People | 1982 |
Reduction of suppressor T lymphocytes in the tropical splenomegaly syndrome.
Topics: Adolescent; Adult; Antibodies; Chloroquine; Female; Humans; Immunoglobulin G; Immunoglobulin M; Indo | 1984 |
Chloroquine resistant malaria in Africa.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Cote d'Ivoire; Drug Resistance, Microbial; | 1980 |
Comparative bio-availability characteristics of different brands of chloroquine available in Nigeria.
Topics: Animals; Biological Availability; Chloroquine; Dogs; Drug Evaluation; Malaria | 1982 |
[Plasmodium falciparum malaria acquired in Kenya with type II or type III resistance to amino-4-quinolines].
Topics: Adult; Chloroquine; Drug Resistance; Female; Humans; Kenya; Malaria; Plasmodium falciparum; Travel | 1983 |
Interactions between oral contraceptives and malaria infections in rhesus monkeys.
Topics: Animals; Antibodies; Chloroquine; Contraceptives, Oral; Drug Interactions; Hematologic Tests; Liver | 1984 |
Effect of chloroquine treatment on complement levels in Plasmodium knowlesi infected Rhesus monkeys.
Topics: Animals; Chloroquine; Complement C3; Complement System Proteins; Macaca mulatta; Malaria | 1984 |
[Falciparum malaria in East African tourists in spite of fansidar prevention. A contribution on increased chloroquine and pyrimethamine-sulfadoxine resistance in areas of East Africa].
Topics: Adult; Africa, Eastern; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Erythrocytes; Fe | 1983 |
[Drug-resistant malaria in East Africa].
Topics: Adult; Africa, Eastern; Aged; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Ma | 1983 |
Chloroquine-resistant falciparum malaria.
Topics: Chloroquine; Female; Humans; Malaria; Middle Aged; Plasmodium falciparum; Tanzania | 1983 |
Uptake of L-tryptophan by erythrocytes infected with malaria parasites (Plasmodium falciparum).
Topics: Biological Transport; Chloroquine; Erythrocytes; Humans; Kinetics; Malaria; Phenylalanine; Phloretin | 1983 |
[A case of chloroquine-resistant tropical malaria from eastern Africa (Kenya)].
Topics: Aged; Chloroquine; Diabetes Complications; Drug Resistance; Humans; Kenya; Malaria; Male; Plasmodium | 1983 |
Malaria at San Lazaro Hospital, Manila, Philippines, 1979-1981.
Topics: Adolescent; Adult; Age Factors; Brain; Child; Child, Preschool; Chloroquine; Drug Resistance, Microb | 1983 |
Combined chloroquine/Fansidar-resistant falciparum malaria appears in East Africa.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Comb | 1983 |
Ineffective erythropoiesis in acute human P. falciparum malaria.
Topics: Acute Disease; Autoradiography; Bone Marrow Examination; Cell Count; Chloroquine; Erythrocytes; Eryt | 1983 |
Mode of action of antimalarial drugs.
Topics: Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Drug Resistance; Heme; Hemin; Hemoglobins; H | 1983 |
Treatment of chloroquine-resistant malaria during pregnancy.
Topics: Adult; Chloroquine; Drug Therapy, Combination; Female; Humans; Malaria; Plasmodium falciparum; Pregn | 1983 |
Chloroquine-resistant malaria.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum | 1983 |
Multiple drug resistance in falciparum malaria from Brazil.
Topics: Adolescent; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium falciparum | 1983 |
Malaria in the emergency department.
Topics: Adolescent; Adult; Chloroquine; District of Columbia; Emergency Service, Hospital; Female; Hospital | 1983 |
Drug resistance in malaria: three cases and a review.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium; Plas | 1983 |
[Tropical malaria caused by chloroquine-resistant Plasmodium falciparum, in the Netherlands also a problem of increasing importance].
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Male; Middle Aged; Net | 1983 |
[Malaria control: prospects?].
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Drug Resistance; Humans; Insect Control; Insect Vect | 1983 |
Transfusion-acquired Plasmodium malariae infection in two premature infants.
Topics: Blood Donors; Chloroquine; Female; Humans; Hyaline Membrane Disease; Infant, Newborn; Infant, Premat | 1983 |
Response to chloroquine of infections with Plasmodium falciparum in the Kivu region of Zaïre. Preliminary observations.
Topics: Child; Child, Preschool; Chloroquine; Democratic Republic of the Congo; Humans; Infant; Malaria; Pla | 1983 |
Plasmodium berghei: influence on granulopoiesis and macrophage production in BALB/c mice.
Topics: Animals; Bone Marrow; Cells, Cultured; Chloroquine; Colony-Forming Units Assay; Colony-Stimulating F | 1983 |
In vitro confirmation of clinical resistance of Plasmodium falciparum to chloroquine in Kenya.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Microbial Sensitivity Tests; | 1983 |
Field evaluation in Kenya of a 48-hour in vitro test for Plasmodium falciparum sensitivity to chloroquine.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Drug Ev | 1983 |
Chloroquine resistance in Plasmodium falciparum from Kenyan infants.
Topics: Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Kenya; Malaria; Plasmodium falciparu | 1983 |
The management of cerebral malaria in African children.
Topics: Africa; Brain Diseases; Child, Preschool; Chloroquine; Drug Administration Schedule; Female; Humans; | 1983 |
Plasmodium falciparum in Kisumu, Kenya: differences in sensitivity to amodiaquine and chloroquine in vitro.
Topics: Amodiaquine; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Kenya; Malaria; Male; M | 1983 |
Chloroquine resistant Plasmodium falciparum: effect of rabbit serum and incubation time on the in vitro (microtechnique) prediction of in vivo resistance.
Topics: Animals; Blood; Chloroquine; Culture Media; Drug Resistance; Humans; Malaria; Plasmodium falciparum; | 1983 |
Chloroquine resistant Plasmodium falciparum on the island of Flores, Indonesia.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Human | 1983 |
RII-RIII chloroquine resistant Plasmodium falciparum malaria from East Africa: studies of the in vivo and in vitro response to chloroquine.
Topics: Adult; Africa, Eastern; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Female; Humans; Malar | 1983 |
[Importation of malaria to Lombardy. II - Analysis of hospitalized cases].
Topics: Chloroquine; Female; Humans; Italy; Malaria; Male; Plasmodium falciparum; Retrospective Studies; Tra | 1983 |
[Survey on the chloroquine susceptibility of Plasmodium falciparum in the Menglun area, Yunnan Province].
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; China; Chloroquine; Female; Humans; Malaria; Ma | 1983 |
Malaria: the fight goes on.
Topics: Antimalarials; Chloroquine; Drug Resistance; Global Health; Humans; Malaria; Plasmodium falciparum; | 1983 |
Clinical management of chloroquine-resistant Plasmodium falciparum malaria in Southeast Asia.
Topics: Antimalarials; Asia, Southeastern; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; | 1983 |
Clinical management of acute falciparum malaria in Tanzania.
Topics: Acute Disease; Administration, Oral; Adult; Antimalarials; Child; Chloroquine; Dose-Response Relatio | 1983 |
Evaluation of amodiaquine treatment of chloroquine-resistant Plasmodium falciparum malaria on Zanzibar, 1982.
Topics: Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Evaluation; Drug Resistance; Humans; Infant; | 1983 |
Comparative evaluation of in-vitro studies on chloroquine resistance of falciparum malaria.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; In Vitro Techniques; India; Malaria; Male; M | 1983 |
[Chloroquine- and fansidar-resistant falciparum malaria treated with minocycline].
Topics: Adult; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; Male; Minocyclin | 1983 |
The Kenyan Saradidi community malaria project: I. Response of Plasmodium falciparum isolates to chloroquine in 1981 and 1982.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; Kenya; Ma | 1983 |
Chloroquine resistant malignant subtertian malaria unmasked by systematic steroid therapy.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum; Predni | 1983 |
Cerebral malaria treated with high doses of chloroquine.
Topics: Adolescent; Adult; Brain Diseases; Child; Chloroquine; Female; Humans; Malaria; Male; Plasmodium fal | 1983 |
In vitro inhibition of intracellular growth of Plasmodium falciparum by immune sera.
Topics: Animals; Aotus trivirgatus; Chloroquine; Erythrocytes; Humans; Immune Sera; Malaria; Methionine; Pla | 1984 |
Primaquine-chloroquine prophylaxis against malaria in Southeast-Asian refugees entering South Australia.
Topics: Asia, Southeastern; Australia; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Muscle Cramp | 1984 |
Response of falciparum malaria to a standard regimen of chloroquine in Khartoum Province, Sudan.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Malaria; M | 1983 |
A review of the new strategy of malaria control by chemotherapy in the National Malaria Eradication Programme.
Topics: Animals; Anopheles; Chloroquine; Humans; India; Malaria; Mosquito Control; National Health Programs; | 1983 |
Landmark article July 20, 1946: Chloroquine for treatment of acute attacks of vivax malaria. By Harry Most, Irving M. London, Charles A. Kane, Paul H. Lavietes, Edmund F. Schroeder and Joseph M. Hayman, Jr.
Topics: Acute Disease; Chloroquine; History, 20th Century; Humans; Malaria; Plasmodium vivax; United States | 1984 |
Landmark perspective: The ascent and decline of chloroquine.
Topics: Chloroquine; History, 20th Century; Malaria; Plasmodium falciparum; Plasmodium vivax; United States | 1984 |
[Malaria: a study of 5 cases].
Topics: Adult; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Plasmodium vi | 1984 |
Malaria--prophylaxis and treatment.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1984 |
Plasmodium falciparum-malaria: resistance to chloroquine, but sensitivity to mefloquine in the Gabon. A prospective in-vitro study.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Gab | 1984 |
Drug resistance of Plasmodium falciparum in Africa with particular reference to chloroquine resistance in Zimbabwe.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Malaria | 1984 |
Chloroquine susceptibility of Plasmodium falciparum in Haiti.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Female; Haiti; Humans; Malaria; Male; Middl | 1983 |
Metabolism of erythrocyte infected with malaria parasite and the action of antimalarial drugs.
Topics: Animals; Chloroquine; Erythrocytes; Glucosephosphate Dehydrogenase; Hemin; Hemoglobins; Malaria; Mic | 1983 |
The treatment of falciparum malaria.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Malaria; Mefloquine; Plasmodium f | 1984 |
Congenital Plasmodium vivax malaria.
Topics: Adult; Chloroquine; Female; Humans; Infant, Newborn; Malaria; Plasmodium vivax; Pregnancy; Pregnancy | 1984 |
Treatment of chloroquine-resistant Plasmodium falciparum malaria.
Topics: Amodiaquine; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Plasmodium fa | 1984 |
Chloroquine-resistant falciparum malaria from Malawi.
Topics: Adult; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; Malawi; Male; Pl | 1984 |
The malarial pigment in rat infected erythrocytes and its interaction with chloroquine. A Mössbauer effect study.
Topics: Animals; Chloroquine; Erythrocytes; Iron; Iron Radioisotopes; Kinetics; Malaria; Pigments, Biologica | 1984 |
[Chloroquine and pyrimethamine/sulfadoxine resistant malaria tropica in a child with diabetes mellitus].
Topics: Adolescent; Chloroquine; Diabetes Mellitus, Type 1; Diagnosis, Differential; Doxycycline; Drug Resis | 1984 |
Probable chloroquine-resistant Plasmodium falciparum malaria in south-western Africa.
Topics: Adult; Africa, Southern; Africa, Western; Animals; Chloroquine; Drug Resistance, Microbial; Humans; | 1984 |
In vitro confirmation of chloroquine-resistant Plasmodium falciparum in southern Africa.
Topics: Africa, Southern; Animals; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falc | 1984 |
Absence of malaria mortality in villagers with chloroquine-resistant Plasmodium falciparum treated with chloroquine.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Drug Administration Schedule; Drug Resistan | 1984 |
Decreased chloroquine sensitivity of Plasmodium falciparum in two Italian travellers from Madagascar.
Topics: Chloroquine; Drug Resistance, Microbial; Female; Humans; Madagascar; Malaria; Middle Aged; Plasmodiu | 1984 |
R-III chloroquine-resistant Plasmodium falciparum malaria from northern Malawi.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malawi; Male; Middle Aged; Plasmodium falc | 1984 |
Concomitant resistance to pyrimethamine and cycloguanil of chloroquine-resistant falciparum malaria from East Africa: an in vitro study of 12 isolates.
Topics: Africa, Eastern; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Microbial Sensitivity Tes | 1984 |
R-II chloroquine-resistant falciparum malaria from Burundi.
Topics: Adult; Burundi; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparu | 1984 |
[Action of chloroquine on glutathione metabolism in erythrocytes parasitized by Plasmodium berghei].
Topics: Animals; Chloroquine; Erythrocytes; Glutathione; Glutathione Reductase; Hematocrit; Malaria; Mice; O | 1984 |
A review of chloroquine resistance by plasmodium falciparum in Kenya.
Topics: Adult; Chloroquine; Drug Resistance; Humans; Kenya; Malaria; Male; Plasmodium falciparum | 1984 |
Ferriprotoporphyrin IX: a mediator of the antimalarial action of oxidants and 4-aminoquinoline drugs.
Topics: Aminoquinolines; Animals; Antimalarials; Cell Membrane; Chloroquine; Erythrocytes; Heme; Hemin; Hemo | 1984 |
Chloroquine resistance and host cell hemoglobin catabolism in Plasmodium berghei.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Heme; Hemoglobins; Iron; Kinetics; M | 1984 |
World malaria situation, 1982. Malaria Action Programme, World Health Organization, Geneva.
Topics: Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Plasmodium falciparum; World | 1984 |
Kenyan chloroquin, fansidar and quninine resistant P. Falciparum.
Topics: Adolescent; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Malar | 1984 |
A new in vitro test for pyrimethamine/sulfadoxine susceptibility of Plasmodium falciparum and its correlation with in vivo resistance in Kenya.
Topics: Adolescent; Child; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Humans; Kenya; M | 1984 |
A comparative micro in-vitro test of P. falciparum to mefloquine and chloroquine in Gadchiroli District, Maharashtra State.
Topics: Animals; Antimalarials; Chloroquine; Humans; India; Malaria; Mefloquine; Microbial Sensitivity Tests | 1984 |
Malaria chemoprophylaxis--which drug?
Topics: Adult; Antimalarials; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Mi | 1983 |
African serum interference in the determination of chloroquine sensitivity in Plasmodium falciparum.
Topics: Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance, Microbial; Humans; Immune Sera; | 1984 |
Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine.
Topics: Ammonium Chloride; Animals; Chloroquine; Endocytosis; Erythrocytes; Humans; Hydrogen-Ion Concentrati | 1984 |
[Treatment of malaria. Update].
Topics: Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Malaria; Plasmodium falc | 1984 |
Chloroquine-resistant Plasmodium falciparum malaria in Zimbabwe.
Topics: Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Plasmodium falciparum; Zimba | 1984 |
[Relapses and indirect fluorescent antibody level in vivax malaria patients after chloroquine and chloroquine-primaquine treatment].
Topics: Antibodies; Chloroquine; Fluorescent Antibody Technique; Humans; Malaria; Plasmodium vivax; Primaqui | 1984 |
[A misdiagnosed case of chloroquine-resistant falciparum malaria].
Topics: Adult; Chloroquine; Diagnostic Errors; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparum | 1984 |
Malaria in Christchurch.
Topics: Chloroquine; Dapsone; Drug Combinations; Humans; Malaria; New Zealand; Plasmodium falciparum; Plasmo | 1984 |
Malaria chemoprophylaxis for multiple drug resistant Plasmodium falciparum in Africa: an increasing problem.
Topics: Adult; Africa; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Human | 1984 |
A review of present antimalaria activities in Africa.
Topics: Adolescent; Adult; Africa; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Infant, New | 1984 |
The impact of malaria chemoprophylaxis in Africa with special reference to Madagascar, Cameroon, and Senegal.
Topics: Adolescent; Cameroon; Child; Child Health Services; Child, Preschool; Chloroquine; Female; Humans; I | 1984 |
The sensitivity of Plasmodium falciparum to chloroquine and amodiaquine in Ibadan, Nigeria.
Topics: Amodiaquine; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Malaria; Male; Microbial | 1984 |
Chloroquine resistant plasmodium falciparum malaria confirmed by in-vitro testing in a district hospital.
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Zambia | 1984 |
[Plasmodium falciparum and drug resistance].
Topics: Adult; Africa, Eastern; Animals; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodiu | 1984 |
[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. I. Study in two regions of the west coast].
Topics: Adolescent; Aged; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Drug Res | 1984 |
[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. II. Study in two regions of the east coast].
Topics: Aminoquinolines; Amodiaquine; Antimalarials; Child; Chloroquine; Drug Resistance, Microbial; Humans; | 1984 |
[4-Aminoquinoline-sensitivity of Plasmodium falciparum in Madagascar. III. Studies in three regions of the interior].
Topics: Aminoquinolines; Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Madaga | 1984 |
Chloroquine resistant Plasmodium falciparum in Sri Lanka.
Topics: Adolescent; Adult; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Pl | 1984 |
Chloroquine resistant Plasmodium falciparum malaria in a local Kenyan: a case report.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Kenya; Malaria; Male; Plasmodium falciparum; | 1984 |
Chloroquine-resistant Plasmodium falciparum malaria in the Netherlands.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Netherlands; Plasmodium falciparum; Prospe | 1984 |
Results of 3-day radical treatment of Plasmodium vivax in North Arcot and South Arcot Districts of Tamil Nadu.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Therapy, Combination; Humans; | 1984 |
Chloroquine resistance of Plasmodium falciparum in Sonapur PHC Area (Assam) detected by micro in vitro and in vivo tests.
Topics: Adolescent; Adult; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Microbial Sensitiv | 1984 |
Chloroquine resistant P. falciparum malaria in Assam and Meghalaya.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falciparum | 1984 |
Malaria in Polish seafarers in 1983.
Topics: Africa, Eastern; Africa, Western; Antimalarials; Chloroquine; Female; Humans; Malaria; Male; Naval M | 1984 |
Chloroquine resistant Plasmodium falciparum malaria confirmed by in vivo testing in Lusaka.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Zambia | 1984 |
Chemoprophylaxis of malaria in Africa.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria | 1983 |
Plasmodium malaria resistant to chloroquine in a Zambian living in Zambia.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium falciparum; Zamb | 1983 |
[Malaria prevention with Fansidar].
Topics: Chloroquine; Double-Blind Method; Drug Combinations; Humans; Malaria; Nigeria; Plasmodium; Pyrimetha | 1983 |
Plasmodium malaria resistant to chloroquine.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Plasmodium falciparum | 1983 |
Update: chloroquine-resistant Plasmodium falciparum--Africa.
Topics: Africa; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1983 |
Falciparum malaria resistant to chloroquine and fansidar: implications for prophylaxis.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; M | 1983 |
Malaria prophylaxis for long term visitors.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; | 1983 |
Falciparum malaria resistant to chloroquine: implications for prophylaxis.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1983 |
Falciparum malaria resistant to chloroquine and Fansidar.
Topics: Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; | 1984 |
Falciparum malaria resistant to chloroquine and Fansidar: implications for prophylaxis.
Topics: Chloroquine; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Malaria; Middle Aged; Pl | 1984 |
A Pakistani woman who arrived with diarrhea.
Topics: Blood; Chloroquine; Diagnosis, Differential; Diarrhea; Female; Humans; Malaria; Middle Aged; New Yor | 1984 |
Effect of antimalarial drugs on psoriasis.
Topics: Adult; Antimalarials; Chloroquine; Dermatitis, Exfoliative; Female; Humans; Malaria; Male; Middle Ag | 1980 |
[Complications of the allergic type during the treatment of malaria attacks with chloroquine].
Topics: Chloroquine; Drug Hypersensitivity; Humans; Malaria | 1984 |
Congenital malaria. Case report and review.
Topics: Chloroquine; Humans; Infant; Malaria; Male; Mexico; New York City | 1984 |
Plasmodium fragile: inhibition of cultures by serum from rhesus monkeys immunized with homologous parasites.
Topics: Animals; Antibody Specificity; Cells, Cultured; Chloroquine; Erythrocytes; Immune Sera; Immunization | 1984 |
Management of Plasmodium falciparum malaria.
Topics: Amodiaquine; Anemia; Antimalarials; Brain Diseases; Chloroquine; Drug Resistance; Female; Humans; Hy | 1984 |
Malaria and chloroquine.
Topics: Adult; Chloroquine; Female; Humans; Malaria; Male | 1984 |
Malaria: recent experience in a community.
Topics: Adolescent; Adult; Alabama; Anemia; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial | 1984 |
Chloroquine resistant malaria.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria | 1984 |
Protection against Plasmodium berghei yoelii in chloroquine- and pyrimethamine-treated mice.
Topics: Animals; Chloroquine; Malaria; Mice; Plasmodium; Pyrimethamine | 1984 |
Residual chloroquine and metabolites in man as a sequel of previous chloroquine medications: a urinary excretion study and its significance.
Topics: Adult; Chloroquine; Female; Humans; Kinetics; Malaria; Male; Time Factors | 1984 |
[Pruritus induced by chloroquine during the treatment of malaria].
Topics: Chloroquine; Humans; Malaria; Pruritus | 1984 |
Kinetics of chloroquine & contraceptive steroids in oral contraceptive users during concurrent chloroquine prophylaxis.
Topics: Adult; Chloroquine; Contraceptives, Oral; Contraceptives, Oral, Combined; Contraceptives, Oral, Synt | 1984 |
[A combined regimen of pyronaridin-artemether-chloroquine (PAC) for the treatment of Plasmodium cynomolgi infection in the rhesus monkey].
Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Therapy, Combination; Macaca mul | 1984 |
Influence of progesterone and estrogen administration on the recrudescence patterns of Plasmodium knowlesi infection in female rhesus monkeys (Macaca mulatta) following initial subcurative chloroquine therapy.
Topics: Animals; Antibody Formation; Chloroquine; Estrogens; Female; Immune Tolerance; Macaca mulatta; Malar | 1984 |
Effects of antimalarial drugs on human natural killer cell activity.
Topics: Antimalarials; B-Lymphocytes; Chloroquine; Humans; Killer Cells, Natural; Lymphocytes; Lymphocytes, | 1983 |
The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects.
Topics: Administration, Oral; Adult; Chloroquine; Chromatography, High Pressure Liquid; Female; Half-Life; H | 1984 |
[Clinical consequences of chloroquine prophylaxis and its interruption in a hyperendemic malaria zone].
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Malaria; Male; Senegal | 1983 |
The blood schizontocidal action of erythromycin against Plasmodium knowlesi infections in Macaca mulatta.
Topics: Animals; Blood; Chloroquine; Erythromycin; Macaca mulatta; Malaria; Male; Plasmodium | 1983 |
Failure to participate in a malaria chemosuppression programme: North Mara, Tanzania.
Topics: Child; Child, Preschool; Chloroquine; Humans; Infant; Interviews as Topic; Malaria; Patient Complian | 1983 |
[Drug prevention of malaria].
Topics: Adult; Age Factors; Antimalarials; Child; Chloroquine; Humans; Malaria | 1983 |
[Drug prevention of malaria].
Topics: Adolescent; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Malari | 1983 |
Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria.
Topics: Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria | 1983 |
Chloroquine-induced pruritus among patients with malaria.
Topics: Adolescent; Adult; Black People; Child; Chloroquine; Female; Humans; Malaria; Male; Nigeria; Pruritu | 1984 |
Theoretical aspects of enzyme induction and inhibition leading to the reversal of resistance to biocides.
Topics: Adult; Chemical Phenomena; Chemistry; Child; Chlorfenvinphos; Chloroquine; Cytochrome P-450 Enzyme S | 1984 |
Role of macrophages in the pathogenesis of endomyocardial fibrosis in murine malaria.
Topics: Animals; Cell Adhesion; Chloroquine; Endocardium; Endomyocardial Fibrosis; Macrophage Activation; Ma | 1984 |
Risks in malaria prevention: alternative prophylaxis with chloroquine plus tetracycline.
Topics: Chloroquine; Drug Therapy, Combination; Humans; Malaria; Tetracycline; Travel | 1984 |
Effect of chloroquine on the peroxide scavenging enzymes glutathione level & lipid peroxidation in rat erythrocytes.
Topics: Animals; Catalase; Chloroquine; Erythrocytes; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide | 1984 |
[Distribution of chloroquine and desethylchloroquine in blood, plasma and erythrocytes of healthy subjects and malaria patients. Assay using HPLC].
Topics: Chloroquine; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Malaria; Male; Plas | 1984 |
Sensitivity of Plasmodium falciparum isolates to chloroquine in Kisumu and Malindi, Kenya.
Topics: Adolescent; Adult; Child; Chloroquine; Humans; Kenya; Malaria; Plasmodium falciparum | 1982 |
Plasmodium berghei: uptake and distribution of chloroquine in infected mouse erythrocytes.
Topics: Animals; Cell Fractionation; Cell Separation; Chloroquine; Dose-Response Relationship, Drug; Erythro | 1982 |
Kinetics of the uptake and elimination of chloroquine in children with malaria.
Topics: Child; Child, Preschool; Chloroquine; Erythrocytes; Female; Half-Life; Humans; Infant; Kinetics; Mal | 1982 |
Ferriprotoporphyrin IX binding substances and the mode of action of chloroquine against malaria.
Topics: Animals; Chloroquine; Heme; Hemin; Malaria; Plasmodium berghei; Serum Albumin, Bovine | 1982 |
High-level chloroquine resistance of Plasmodium falciparum malaria acquired in Kenya.
Topics: Adult; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Female; Humans; Kenya; Malaria; Plas | 1982 |
Adoptive transfer of immunity to Plasmodium berghei with spleen cells from drug cured mice.
Topics: Animals; B-Lymphocytes; Chloroquine; Female; Immunization, Passive; Malaria; Male; Mice; Mice, Inbre | 1982 |
Micro in vitro chloroquine sensitivity test for Plasmodium falciparum without the use of candle jar.
Topics: Cellophane; Chloroquine; Humans; In Vitro Techniques; Malaria; Microbial Sensitivity Tests; Plasmodi | 1982 |
A note on chloroquine sensitivity in P. falciparum in Sonepat District (Haryana).
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; India; | 1981 |
[Malarial infections with Plasmodium falciparum resistant to chloroquine treatment. The situation in Brazil (1960-1981)].
Topics: Brazil; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Microbial Sensitivity Tests; Plasm | 1981 |
[Treatment of malaria with a combination of 3 drugs on São Luís Island, Maranhão, Brazil].
Topics: Antimalarials; Brazil; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Plasmodium falciparu | 1981 |
A case of fansidar-resistant Plasmodium falciparum from Tanzania.
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; | 1982 |
Fansidar-resistant Plasmodium falciparum infection from Tanzania.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Ma | 1982 |
Plasmodium falciparum: rapid assay for in vitro inhibition due to human serum from residents of malarious areas.
Topics: Adult; Animals; Chloroquine; Dialysis; Humans; Immune Sera; Immunologic Techniques; In Vitro Techniq | 1982 |
[Quartan malaria in a 2-year-old girl].
Topics: Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; Italy; Malaria; Plasmodiu | 1982 |
[Malarial infections caused by Plasmodium falciparum resistant to chloroquine treatment. The situation in Brazil (1960-1981)].
Topics: Antimalarials; Brazil; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1981 |
[Treatment of malaria with a combination of 3 drugs on the Island of São Luis, Maranhão, Brazil].
Topics: Antimalarials; Chloroquine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; | 1981 |
[Focus of malaria in the metropolitan region of Recife].
Topics: Anopheles; Brazil; Chloroquine; Disease Outbreaks; Drug Therapy, Combination; Humans; Malaria; Plasm | 1981 |
In vitro assessment of 2-acetylpyridine thiosemicarbazones against chloroquine-resistant Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Malaria; Mefloquine; Mice; Plasmodium falcipar | 1982 |
Incipient resistance of Plasmodium falciparum to chloroquine among a semi-immune population of the United Republic of Tanzania. 2. The impact of chloroquine used as a chemosuppressant on the immune status of the population.
Topics: Anopheles; Chloroquine; Drug Resistance, Microbial; Humans; Immunity; Malaria; Plasmodium falciparum | 1982 |
Imported malaria in adults in Auckland.
Topics: Adolescent; Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Kenya; Malaria; Male; Mi | 1982 |
[Malaria--also a problem in our country].
Topics: Adult; Chloroquine; Doxycycline; Humans; India; Malaria; Male; Plasmodium falciparum; Plasmodium viv | 1982 |
Effect of malaria on erythrocytic reduced glutathione and activity of related enzymes.
Topics: Chloroquine; Female; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathion | 1982 |
[Resistance of Plasmodium falciparum to fansidar, quinine and tetracycline].
Topics: Adolescent; Chloroquine; Drug Administration Schedule; Drug Combinations; Drug Resistance, Microbial | 1982 |
[Chloroquine resistant falciparum malaria in East Africa illustrated by a case of cerebral malaria].
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Encephalitis; Humans; Malaria; Male; Plasmodium falc | 1982 |
[Chloroquine resistant falciparum malaria in East Africa].
Topics: Adolescent; Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Madagascar; Malaria; Mal | 1982 |
Diminished red blood cell deformability in uncomplicated human malaria. A preliminary report.
Topics: Adult; Chloroquine; Erythrocytes, Abnormal; Humans; Malaria; Male; Plasmodium falciparum; Plasmodium | 1982 |
Adenosine triphosphate levels in mouse erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium berghei.
Topics: Adenosine Triphosphate; Animals; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Malaria; Mal | 1982 |
[Studies on piperaquine as long-acting antimalarial drug against Plasmodium berghei in mice].
Topics: Animals; Antimalarials; Chloroquine; Delayed-Action Preparations; Female; Malaria; Mice; Plasmodium | 1982 |
Clinical profile of malaria in eastern parts of India.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; | 1982 |
[Preliminary in vitro study of drug sensitivity of Plasmodium falciparum in Madagascar].
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; | 1982 |
The course of untreated Plasmodium inui infections in the rhesus monkey (Macaca mulatta).
Topics: Animals; Chloroquine; Erythrocytes; Female; Haplorhini; Macaca mulatta; Malaria; Male; Plasmodium | 1980 |
Hydroxypiperaquine phosphate in treating chloroquine resistant falciparum malaria.
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Quinolines | 1981 |
Malaria prevention in travellers from the United Kingdom. Report of meetings convened by the Ross Institute.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Administration Schedule; Drug | 1981 |
[A clinical study on 8 patients with malaria at the First Department of Internal Medicine, Yokohama City University School of Medicine in 20 years (author's transl)].
Topics: Adult; Chloroquine; Humans; Japan; Malaria; Male; Middle Aged | 1981 |
Chloroquine-resistant Plasmodium falciparum malaris acquired in East Africa--Pennsylvania.
Topics: Adolescent; Africa, Eastern; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Pennsyl | 1981 |
Epidemiology: malaria 1980.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Middle Aged; Plasmodium falciparum; | 1982 |
[Eye damage as a result of long-term malaria prophylaxis with chloroquine (author's transl)].
Topics: Adult; Aged; Child; Chloroquine; Eye Diseases; Female; Humans; Long-Term Care; Malaria; Male; Middle | 1982 |
Fatal falciparum malaria and the availability of parenteral antimalarial drugs in hospitals.
Topics: Chloroquine; England; Formularies, Hospital as Topic; Humans; Infusions, Parenteral; Malaria; Male; | 1982 |
Revised recommendations for malaria chemoprophylaxis for travelers to East Africa.
Topics: Africa, Eastern; Chloroquine; Female; Humans; Infant; Infant, Newborn; Malaria; Pregnancy; Travel; U | 1982 |
[Two cases of benign tertian malaria].
Topics: Adolescent; Chloroquine; Humans; Japan; Malaria; Male; Papua New Guinea; Plasmodium vivax | 1982 |
Prevention of malaria in travelers 1982.
Topics: Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium; Plasmodium falc | 1982 |
Progressive chloroquine retinopathy.
Topics: Chloroquine; Fluorescein Angiography; Follow-Up Studies; Humans; Macular Degeneration; Malaria; Male | 1983 |
Acute clinical malaria (Plasmodium inui) in a cynomolgus monkey (Macaca fascicularis).
Topics: Acute Disease; Animal Population Groups; Animals; Animals, Wild; Antimalarials; Chloroquine; Disease | 1983 |
Hematologic characterization of naturally occurring malaria (Plasmodium inui) in cynomolgus monkeys (Macaca fascicularis).
Topics: Animals; Chloroquine; Erythrocyte Count; Erythrocyte Indices; Hematocrit; Hemoglobins; Macaca; Macac | 1983 |
Tropical splenomegaly syndrome (T.S.S.) in a European.
Topics: Aged; Chloroquine; Humans; Malaria; Male; Proguanil; Splenomegaly | 1983 |
The effect of ferriprotoporphyrin IX and chloroquine on phospholipid monolayers and the possible implications to antimalarial activity.
Topics: Chloroquine; Heme; Hemin; Humans; Liposomes; Malaria; Phosphatidylcholines; Structure-Activity Relat | 1983 |
Comparative study of amino acid production in erythrocytes parasitized by Plasmodium sp. and Babesia hylomysci.
Topics: Amino Acids; Animals; Antimalarials; Autoradiography; Babesiosis; Chloroquine; Erythrocytes; Female; | 1983 |
Determination of chloroquine and its major metabolite in blood using perfluoroacylation followed by fused-silica capillary gas chromatography with nitrogen-sensitive detection.
Topics: Chloroquine; Chromatography, Gas; Drug Resistance, Microbial; Gas Chromatography-Mass Spectrometry; | 1983 |
[Unexpected effect of preventive antimalarial treatment].
Topics: Chloroquine; Female; Graves Disease; Humans; Malaria; Middle Aged; Ophthalmoplegia | 1981 |
Drugs used in the treatment and prophylaxis of malaria. The Royal Melbourne Hospital Pharmacy Department.
Topics: Adult; Antimalarials; Child; Chloroquine; Humans; Infant; Malaria | 1981 |
Malaria.
Topics: Chloroquine; Humans; Malaria; Male | 1981 |
Danger of haemolysis from primaquine use.
Topics: Chloroquine; Drug Therapy, Combination; Hemolysis; Humans; Malaria; Primaquine | 1982 |
Plasmodium chabaudi-infection of mice: effects of chloroquine and mefloquine. Inhibition of ornithine decarboxylase activity.
Topics: Acridines; Animals; Antimalarials; Carboxy-Lyases; Chloroquine; Enzyme Repression; Erythrocyte Membr | 1981 |
Antimalarial activity of mefloquine and chloroquine against blood induced Plasmodium knowlesi infection in rhesus monkeys.
Topics: Animals; Antimalarials; Chloroquine; Female; Macaca mulatta; Malaria; Male; Mefloquine; Piperidines; | 1981 |
Plasmodium berghei: T cell-dependent autoimmunity.
Topics: Animals; Antigen-Antibody Complex; Antigens, Viral; Autoantibodies; Chloroquine; Erythrocytes; Femal | 1980 |
Malaria chemoprophylaxis.
Topics: Anopheles; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falci | 1980 |
Chemoprophylaxis in malaria.
Topics: Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium falciparum; Pregnancy; | 1980 |
[A case of chloroquine-resistant (R1) falciparum malaria from the East African Comoros Islands (author's transl)].
Topics: Africa, Eastern; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum; Pyrimethamine; Sulfadoxi | 1980 |
Depressed malarial immunity in pregnant mice.
Topics: Aging; Animals; Chloroquine; Female; Immunity; Malaria; Mice; Mice, Inbred Strains; Plasmodium bergh | 1980 |
Distribution of chloroquine in normal, pronase-treated and malaria-infected red cells.
Topics: Animals; Binding Sites; Chloroquine; Erythrocyte Membrane; Erythrocytes; Hemolysis; Malaria; Mice; P | 1980 |
Chloroquine-resistant falciparum malaria.
Topics: Australia; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; New Guinea; Plasmodium falcipar | 1980 |
[Acute respiratory insufficiency as a complication of falciparum malaria].
Topics: Acute Disease; Chloroquine; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Positive-Pres | 1980 |
Drug-resistant malaria--occurrence, control, and surveillance.
Topics: Aminoquinolines; Asia; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falcipar | 1980 |
Chloroquine sensitivity of Plasmodium falciparum in Ibadan, Nigeria.
Topics: Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; Infant; Infant, Ne | 1980 |
Study of Plasmodium falciparum resistance to 4-Aminoquinolines (Chloroquine) in Sabah, Malaysia.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; I | 1980 |
Malaria prophylaxis in travelers.
Topics: Africa; Antimalarials; Asia; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans; Infant | 1980 |
Congenital malaria due to Plasmodium falciparum.
Topics: Chloroquine; Female; Humans; Infant, Newborn; Malaria; Plasmodium falciparum; Serologic Tests | 1980 |
The World Health Organisation North Fly clinico-epidemilogical pilot study.
Topics: Anemia; Child; Child, Preschool; Chloroquine; Cysticercosis; Elephantiasis; Epidemiologic Methods; F | 1980 |
[Malaria: recent clinical experience in the Eastern townships].
Topics: Adolescent; Adult; Aged; Canada; Child; Child, Preschool; Chloroquine; Female; Humans; Malaria; Male | 1980 |
Chloroquine resistant Plasmodium falciparum malaria in East New Britain, Papua New Guinea.
Topics: Amodiaquine; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria; Plasmodium fal | 1980 |
Malaria and growth stunting in young children of the highlands of Papua New Guinea.
Topics: Amodiaquine; Anthropometry; Child; Child, Preschool; Chloroquine; Female; Growth Disorders; Health S | 1980 |
Malaria in southeast Queensland in 1979.
Topics: Adolescent; Adult; Australia; Child; Child, Preschool; Chloroquine; Dapsone; Female; Humans; Infant; | 1980 |
[A 2d patient with tropical malaria contracted in a natural way in the Netherlands].
Topics: Bone Marrow; Child; Chloroquine; Female; Humans; Malaria; Plasmodium falciparum | 1981 |
Plasmodium falciparum strains from Papua New Guinea: culture characteristics and drug sensitivity.
Topics: Adolescent; Adult; Animals; Child, Preschool; Chloroquine; Humans; Malaria; New Guinea; Plasmodium f | 1980 |
Response to 600 mg amodiaquine base with 45 mg primaquine as presumptive treatment in chloroquine resistant Plasmodium falciparum infection in Assam.
Topics: Adolescent; Adult; Amodiaquine; Child; Chloroquine; Drug Resistance, Microbial; Humans; India; Infan | 1980 |
[Chloroquine-resistant Plasmodium falciparum malaria from Tanzania sensitivity tested in vivo].
Topics: Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium falci | 1981 |
Chloroquine resistant malaria in Africa.
Topics: Africa; Chloroquine; Malaria; Plasmodium falciparum | 1981 |
Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture.
Topics: Animals; Chloroquine; Culture Media; Drug Resistance, Microbial; Humans; In Vitro Techniques; Malari | 1981 |
Malaria: are we prepared?
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1981 |
Neonatal malaria in Southern Thailand.
Topics: Chloroquine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Malaria; Male; Plasmodium f | 1981 |
Chloroquine resistant Plasmodium falciparum infection from Lampung and South Sumatra, Indonesia.
Topics: Adult; Chloroquine; Drug Resistance; Humans; Indonesia; Malaria; Male; Plasmodium falciparum; Pyrime | 1981 |
Malaria in Cape Town. A report of 3 cases and a review of current therapy and prophylaxis.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Diagnosis, Differential; Drug Administratio | 1981 |
Malaria in children.
Topics: Child, Preschool; Chloroquine; Female; Humans; Malaria; Male; Ohio; Plasmodium vivax; Primaquine; Tr | 1981 |
Clinical drug-resistant falciparum malaria acquired from cultured parasites.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum | 1981 |
Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon.
Topics: Brazil; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Plasmodium falciparu | 1981 |
Chloroquine-resistant falciparum malaria from East Africa.
Topics: Adult; Africa, Eastern; Aged; Chloroquine; Drug Administration Schedule; Drug Resistance; Female; Hu | 1981 |
Chloroquine resistant malaria: association with enhanced plasmodial protease activity.
Topics: Chloroquine; Drug Resistance, Microbial; Hemoglobins; Humans; Kinetics; Malaria; Peptide Hydrolases; | 1981 |
[Think of malaria!].
Topics: Adult; Chloroquine; Humans; Lung Abscess; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Th | 1981 |
Inhibition of in vitro growth of Plasmodium falciparum by immune serum from monkeys.
Topics: Animals; Antibody Formation; Aotus trivirgatus; Cebidae; Chloroquine; Dose-Response Relationship, Im | 1981 |
Blood schizontocidal activity of antibiotics against Plasmodium berghei sensitive as well as resistant to chloroquine, pyrimethamine and primaquine.
Topics: Animals; Anti-Bacterial Agents; Chloroquine; Drug Resistance; Malaria; Mice; Plasmodium berghei; Pri | 1981 |
Neonatal malaria.
Topics: Chloroquine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Malaria; Male; Plasmodium vivax | 1981 |
Treatment of tropical diseases (malaria and amoebiasis).
Topics: Amebiasis; Chloroquine; Humans; Malaria; Metronidazole; Plasmodium falciparum | 1981 |
Use of the in vitro microtechnique for the assessment of drug sensitivity of Plasmodium falciparum in Sennar, Sudan.
Topics: Adolescent; Adult; Aged; Aminoquinolines; Child; Child, Preschool; Chloroquine; Humans; In Vitro Tec | 1980 |
Sensitive high-performance liquid chromatographic analysis for chloroquine in body fluids. Application to studies of drug resistance in Plasmodium falciparum.
Topics: Chloroquine; Chromatography, High Pressure Liquid; Drug Resistance; Humans; Malaria; Plasmodium falc | 1981 |
An authentic case of pulmonary malaria caused by Plasmodium falciparum.
Topics: Adult; Anemia; Asthma; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum | 1981 |
[In vitro culture of Plasmodium falciparum, a new contribution to the antimalaria campaign].
Topics: Animals; Chloroquine; Culture Media; Erythrocytes; Humans; In Vitro Techniques; Malaria; Plasmodium | 1981 |
[Plasmodium falciparum malaria resistant to polychemotherapy. Usefulness of pathogen culture (author's transl)].
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; H | 1981 |
Malaria 'breakthroughs' and resistance to chloroquine in Africa. Case reports.
Topics: Adolescent; Adult; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Middle Aged; Plasmod | 1981 |
Chloroquine-resistant falciparum malaria in Madagascar and Kenya.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Kenya; Madagascar; Malaria; Plasmodi | 1981 |
Angioimmunoblastic lymphadenopathy associated with chronic Plasmodium malariae infection.
Topics: Antimalarials; Chloroquine; Chronic Disease; Humans; Immunoblastic Lymphadenopathy; Malaria; Male; M | 1981 |
Sustained-release implants in the chemotherapy of experimental rodent malaria I. A comparison of the effects of some antimalarials in polydimethylsiloxane matrices.
Topics: Animals; Antimalarials; Chloroquine; Dimethylpolysiloxanes; Drug Implants; Malaria; Male; Mefloquine | 1981 |
Assessment of chloroquine sensitivity of Plasmodium falciparum in Choluteca, Honduras.
Topics: Adult; Aged; Child; Chloroquine; Drug Resistance, Microbial; Female; Honduras; Humans; Malaria; Male | 1981 |
Results of treatment with 600 mg. base of chloroquine and 45 mg base of primaquine in P. falciparum in Greater Nicobar and Little Andaman Islands.
Topics: Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium falciparum; Primaquine | 1981 |
Doxycycline in the treatment of falciparum malaria among aborigine children in West Malaysia.
Topics: Child; Child, Preschool; Chloroquine; Doxycycline; Drug Administration Schedule; Drug Resistance; Hu | 1981 |
Serum concentrations of chloroquine in a patient with a late recrudescence of Kenyan Plasmodium falciparum malaria.
Topics: Chloroquine; Drug Administration Schedule; Drug Resistance; Humans; Malaria; Male; Middle Aged; Plas | 1981 |
Chloroquine sensitivity of Plasmodium falciparum in Ibadan, Nigeria: II. Correlation of in vitro with in vivo sensitivity.
Topics: Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Malaria; Microbial | 1981 |
Acute malaria in children in Madang: endemicity, clinical presentation and treatment.
Topics: Amodiaquine; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria; Papua New Guinea; Plas | 1981 |
Chloroquine-resistant Plasmodium falciparum malaria in Madang children.
Topics: Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Infant; Malaria; Male; Papua | 1981 |
Chronic, patent Plasmodium berghei malaria in splenectomized mice.
Topics: Animals; Antibody Formation; Aspartate Aminotransferases; Chloroquine; Hematocrit; Immunization; Mal | 1982 |
[Current therapy and prevention of malaria and perspectives for the future].
Topics: Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Plasmodium falciparum; P | 1982 |
Forest malaria in Bangladesh. I. Parasitology.
Topics: Adolescent; Adult; Aging; Bangladesh; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; | 1982 |
An analysis of the relationship of host factors to clinical falciparum malaria by multiple regression techniques.
Topics: Adult; Age Factors; Black People; Body Weight; Chloroquine; Clindamycin; Fever; Humans; Malaria; Mal | 1982 |
Inhibition of antibody-binding as a radioimmunoassay for Plasmodium berghei infection in rats.
Topics: Animals; Antibodies; Chloroquine; Erythrocytes; Kinetics; Malaria; Plasmodium berghei; Radioimmunoas | 1982 |
Comparative studies on the immunogenicity of infective and attenuated sporozoites of Plasmodium berghei.
Topics: Animals; Antibody Formation; Chloroquine; Female; Immunization; Malaria; Mice; Mice, Inbred A; Plasm | 1982 |
Incipient resistance of Plasmodium falciparum to chloroquine among a semi-immune population of the United Republic of Tanzania. 1. Results of in vivo and in vitro studies and of an ophthalmological survey.
Topics: Adolescent; Child; Chloroquine; Drug Resistance; Female; Humans; Immunity; Malaria; Male; Plasmodium | 1982 |
Chloroquine resistant P. falciparum in Chandrapur district of Maharastra state.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falciparum | 1981 |
Drug-resistant malaria in Africa. A case report and review of the problem and treatment.
Topics: Adult; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Male; Plasmodium fa | 1982 |
[Investigation on the sensitivity of plasmodium falciparum to chloroquine at Qianjia, Hainan Island (author's transl)].
Topics: China; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1982 |
Determination of chloroquine and its desethyl metabolite in plasma, red blood cells and urine by liquid chromatography.
Topics: Chloroquine; Chromatography, Liquid; Erythrocytes; Humans; Malaria | 1982 |
Malaria in the UK. Some observations on six years' experience in Leeds and Middlesbrough.
Topics: Adult; Brain Diseases; Chloroquine; England; Humans; Leukocyte Count; Malaria; Male; Middle Aged; Pl | 1982 |
Congenital malaria: a report of four cases and a review.
Topics: Asia, Southeastern; Chloroquine; Female; Humans; Infant, Newborn; Malaria; Maternal-Fetal Exchange; | 1982 |
A pyrimethamine-chloroquine combination for malaria prophylaxis during pregnancy.
Topics: Abnormalities, Drug-Induced; Chloroquine; Drug Combinations; Female; Fetus; Humans; Malaria; Pregnan | 1982 |
[A case of methemoglobinemia and agranulocytosis during the treatment of malaria (pl. ovale) with arequine and primaquine].
Topics: Adult; Agranulocytosis; Antimalarials; Chloroquine; Humans; Malaria; Male; Methemoglobinemia; Primaq | 1982 |
[Prevention of recurrence of malaria with primaquine].
Topics: Adult; Child; Child, Preschool; Chloroquine; Follow-Up Studies; Humans; Malaria; Male; Middle Aged; | 1982 |
[Antimalarials for Danes in tropical countries].
Topics: Antimalarials; Chloroquine; Denmark; Humans; Malaria; Travel; Tropical Climate | 1982 |
[Antimalarials for Finnish foreign travelers].
Topics: Antimalarials; Chloroquine; Finland; Humans; Malaria; Travel; Tropical Climate | 1982 |
[The confusion concerning antimalarials needs to be dispelled].
Topics: Africa, Eastern; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Norway; Tr | 1982 |
[Hospitalization for malaria at the Kantonspital and St. Clara Hospital, Basle, from 1970 to 1979].
Topics: Adult; Aged; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Switzerland | 1982 |
Pigmentary skin changes associated with ocular chloroquine toxicity in Ghana.
Topics: Adult; Chloroquine; Female; Ghana; Humans; Malaria; Middle Aged; Pigmentation Disorders; Retinal Dis | 1980 |
Comparative efficacies of quinine and chloroquine as companions to primaquine in a curative drug regimen.
Topics: Animals; Chloroquine; Drug Administration Schedule; Drug Therapy, Combination; Macaca mulatta; Malar | 1981 |
[The therapy with synthetic antimalarial drugs controlled by fluorescence electroretinography (author's transl)].
Topics: Chloroquine; Electroretinography; Fluorescence; Humans; Malaria; Retinal Diseases | 1980 |
The management and treatment of malaria (a personal view).
Topics: Chloroquine; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Infectious; Proguani | 1980 |
[Malaria chemotherapy].
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; Pyrimeth | 1981 |
Chloroquine effects on parasite and host membranes of intraerythrocytic Plasmodium chabaudi.
Topics: Animals; Cell Membrane; Chloroquine; Erythrocyte Membrane; Erythrocytes; Malaria; Mice; Plasmodium | 1981 |
Use and misuse of 4-aminoquinoline antimalarials in tropical Africa and re-examination of itch reaction to these drugs.
Topics: Amodiaquine; Chloroquine; Health Surveys; Humans; Malaria; Nigeria; Pruritus | 1981 |
Malaria in Cape Town.
Topics: Adult; Child; Chloroquine; Humans; Malaria; Primaquine | 1981 |
Chloroquine psychosis: a chemical psychosis?
Topics: Adolescent; Adult; Chloroquine; Female; Humans; Malaria; Male; Psychoses, Substance-Induced | 1981 |
Malaria prophylaxis.
Topics: Antimalarials; Child; Chloroquine; Humans; Malaria | 1981 |
[Clinical observation of treatment of malignant malaria with derivatives of Qinghaosu "224" and "242" (author's transl)].
Topics: Antimalarials; Chloroquine; Humans; Malaria | 1981 |
[Observation of therapeutic effect of single-dose combined administration of Qinghaosu, sulphomethoxine, pyrimethamine and primaquine in the treatment of chloroquine-resistant malignant malaria (author's transl)].
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistanc | 1981 |
[Inadequate effect of malaria prevention].
Topics: Chloroquine; Denmark; Female; Guinea-Bissau; Humans; Malaria; Male; Proguanil; Recurrence | 1980 |
Is the HpO phenomenon in tropical populations really genetic?
Topics: Adult; Chloroquine; Female; Haptoglobins; Humans; Malaria; Male; Phenotype; Time Factors | 1980 |
Intravascular haemolysis and renal insufficiency in children with glucose-6-phosphate dehydrogenase deficiency, following antimalarial therapy.
Topics: Acute Kidney Injury; Child; Child, Preschool; Chloroquine; Erythrocyte Aggregation; Female; Glucosep | 1980 |
Suspected chloroquine-resistant malaria in Nigeria.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Nigeria | 1980 |
Fever and Chills.
Topics: Adult; Chloroquine; Humans; Malaria; Male; Primaquine | 1980 |
Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications.
Topics: Animals; Chloroquine; Drug Interactions; Erythrocytes; Heme; Hemin; Hemolysis; In Vitro Techniques; | 1980 |
[Malaria prevention].
Topics: Antimalarials; Chloroquine; Humans; Insect Repellents; Malaria | 1980 |
Acute chloroquine toxicity in infants.
Topics: Chloroquine; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Malaria; Male | 1980 |
[Acute intermittent porphyria detected during treatment of malaria with chloroquine].
Topics: Acute Disease; Adult; Chloroquine; Diagnosis, Differential; Diagnostic Errors; Humans; Malaria; Male | 1980 |
The effect of malarial chemoprophylaxis on immunoglobulin levels of pregnant Nigerian women and the newborn.
Topics: Chloroquine; Female; Fetal Blood; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immu | 1980 |
[Continued malaria prevention].
Topics: Chloroquine; Humans; Malaria | 1980 |
Chloroquine poisoning: double barrier prevention.
Topics: Child; Chloroquine; Drug Packaging; Humans; Malaria; Poisoning | 1981 |
The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity.
Topics: Adolescent; Adult; Age Factors; Antibodies, Protozoan; Child; Child, Preschool; Chloroquine; Female; | 1995 |
The chemotherapy of rodent malaria. LII. Response of Plasmodium yoelii ssp. NS to mefloquine and its enantiomers.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Malaria; Mefloquine; Mice; Plasmodium yoelii; | 1995 |
Perception and utilisation of malaria prophylaxis among pregnant women in Dar es Salaam, Tanzania.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Cross-Sectional Studies; Female; Health Knowledge, At | 1995 |
Antimalarials for Africa.
Topics: Africa; Chloroquine; Humans; Malaria; Mefloquine; Travel; United Kingdom | 1994 |
[Relentless fight against malaria in Thailand].
Topics: Antimalarials; Chloroquine; History, 17th Century; History, 18th Century; History, 19th Century; His | 1995 |
Malaria prophylaxis. Mefloquine toxicity should limit its use to treatment alone.
Topics: Africa; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Mefloquine; Proguanil; Tra | 1995 |
Malaria prophylaxis. Psychological problems after mefloquine and chloroquine.
Topics: Chloroquine; Humans; Malaria; Mefloquine; Mental Disorders | 1995 |
Hepatotoxic reaction to chloroquine phosphate in a patient with previously unrecognized porphyria cutanea tarda.
Topics: Antimalarials; Chloroquine; Coproporphyrins; Female; Humans; Liver; Malaria; Middle Aged; Porphyria | 1995 |
Status of hepatic glutathione-S-transferase(s) during Plasmodium berghei infection and chloroquine treatment in Mastomys natalensis.
Topics: Animals; Chloroquine; Cytosol; Glutathione Transferase; Liver; Malaria; Microsomes, Liver; Mitochond | 1995 |
Plasmodium berghei: implication of intracellular glutathione and its related enzyme in chloroquine resistance in vivo.
Topics: Animals; Chloroquine; Drug Resistance; Glutathione; Glutathione Peroxidase; Glutathione Reductase; G | 1995 |
[Health personnel and population practices in the diagnosis of malaria and use of antimalarial drugs in Dakar].
Topics: Antimalarials; Chloroquine; Drug Prescriptions; Health Knowledge, Attitudes, Practice; Health Person | 1995 |
The pharmacokinetics of three multiple dose regimens of chloroquine: implications for malaria chemoprophylaxis.
Topics: Adult; Analysis of Variance; Chloroquine; Drug Administration Schedule; Female; Follow-Up Studies; H | 1995 |
[Malaria prevention with mefloquine].
Topics: Altitude Sickness; Calcium Channel Blockers; Chloroquine; Drug Interactions; Humans; Malaria; Mefloq | 1995 |
First report of in vitro susceptibility of Plasmodium malariae Thai isolates to chloroquine.
Topics: Animals; Chloroquine; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Malaria; Plasmo | 1994 |
Malaria treatment in Vanuatu: new national treatment guidelines.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Female; H | 1994 |
Chloroquine encapsulated in malaria-infected erythrocyte-specific antibody-bearing liposomes effectively controls chloroquine-resistant Plasmodium berghei infections in mice.
Topics: Animals; Antibodies, Monoclonal; Chloroquine; Drug Carriers; Drug Resistance; Erythrocytes; Liposome | 1995 |
Controlling malaria.
Topics: Chloroquine; Humans; Malaria; Seasons; Zambia | 1994 |
Malaria parasites and chloroquine concentrations in Tanzanian schoolchildren.
Topics: Adolescent; Animals; Child; Chloroquine; Female; Humans; Malaria; Male; Plasmodium falciparum; Tanza | 1994 |
[A case of Plasmodium ovale malaria with thrombocytopenia and an abnormality grade in FDP concentration despite the use of chloroquine as a malaria prophylaxis].
Topics: Animals; Chloroquine; Fibrin Fibrinogen Degradation Products; Humans; Malaria; Male; Middle Aged; Pl | 1995 |
The role of free radicals and antioxidative enzymes in erythrocytes and liver cells in the course of Plasmodium berghei and Plasmodium vinckei infection of mice.
Topics: Animals; Antioxidants; Catalase; Chloroquine; Drug Synergism; Erythrocytes; Free Radicals; Glutathio | 1994 |
Investigation of chloroquine intake in Biombo region, Guinea Bissau.
Topics: Animals; Chloroquine; Chromatography, High Pressure Liquid; Drug Resistance; Enzyme-Linked Immunosor | 1994 |
[Development and trends from 1986 to 1993 of the attitude of intercontinental travellers on departure from France, with respect to malaria prophylaxis].
Topics: Africa South of the Sahara; Attitude to Health; Chloroquine; France; Humans; Malaria; Mefloquine; Mo | 1993 |
Anti-inflammatory, antipyretic and anti-malarial activities of a West African medicinal plant--Picralima nitida.
Topics: Africa; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Antimalarials; Aspirin; Chloroq | 1994 |
[Malaria in children at the Sihanoukville Hospital (Cambodia)].
Topics: Cambodia; Child; Chloroquine; Hospitals; Humans; Malaria; Malaria, Cerebral; Malaria, Falciparum; Ma | 1994 |
The chemosensitivity of the rodent malarias--relationships with the biology of merozoites.
Topics: Animals; Chloroquine; Drug Resistance; Malaria; Mice; Plasmodium; Rodent Diseases; Species Specifici | 1994 |
Plasmodium falciparum and Plasmodium berghei: effect of magnesium on the development of parasitemia.
Topics: Analysis of Variance; Animals; Calcium; Chloroquine; Culture Media; Dose-Response Relationship, Drug | 1995 |
Confused malaria chemoprophylaxis.
Topics: Chloroquine; Clinical Protocols; Drug Resistance; Humans; Malaria; Mefloquine; Proguanil; Risk Facto | 1994 |
The immunomodulating effect of a new polyamine (the MAP-1987) administered with chloroquine in plasmodia infected mice.
Topics: Adjuvants, Immunologic; Animals; Chloroquine; Malaria; Mice; Peptides; Plasmodium berghei; Polyamine | 1994 |
Effect of Plasmodium berghei infection and antimalarial treatment on heme synthesis in mice.
Topics: 5-Aminolevulinate Synthetase; Animals; Chloroquine; Ferrochelatase; Heme; Liver; Malaria; Mice; Plas | 1994 |
No evidence for chloroquine-associated retinopathy among missionaries on long-term malaria chemoprophylaxis.
Topics: Adult; Chloroquine; Cohort Studies; Drug Administration Schedule; Female; Fibromyalgia; Humans; Mala | 1994 |
Inter-subject variability in biological fluid drug levels during long-term malaria prophylaxis with chloroquine/proguanil.
Topics: Adolescent; Adult; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Male; Proguanil | 1994 |
Antimalarial activity of cedronin.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Glaucarubin; Humans; In Vitro Techniques; KB C | 1994 |
Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection.
Topics: Animals; Antimalarials; Chalcone; Chalcones; Chloroquine; Drug Resistance; Female; Hypoxanthines; Ma | 1994 |
Use of specific polyclonal antibodies for site specific drug targeting to malaria infected erythrocytes in vivo.
Topics: Animals; Antibodies; Antibody Specificity; Chloroquine; Drug Carriers; Erythrocytes; Immunoglobulin | 1993 |
[Effect of spermidine on uptake of chloroquine by Plasmodium berghei].
Topics: Animals; Chloroquine; Drug Therapy, Combination; Malaria; Mice; Plasmodium berghei; Spermidine | 1993 |
Management of malaria before and after introduction of a treatment protocol at the Eldoret District Hospital.
Topics: Adult; Altitude; Chloroquine; Clinical Protocols; Decision Trees; Diagnosis, Differential; Drug Cost | 1994 |
Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon.
Topics: Adolescent; Adult; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Animals; Brazil; Child; Child | 1994 |
A difficult patient.
Topics: Adult; Celiac Disease; Chloroquine; Diagnosis, Differential; Fatigue; Female; Humans; Malaria; Patie | 1994 |
[Cytokines and malaria. A study of TNF-alpha, IL1-beta, IL6 and IL2R in 28 patients].
Topics: Adolescent; Adult; Amodiaquine; C-Reactive Protein; Chloroquine; Humans; Interleukin-1; Interleukin- | 1994 |
Malaria infection in kidney transplant recipients.
Topics: Adult; Biopsy; Chloroquine; Creatinine; Female; Humans; Immunosuppressive Agents; Kidney Transplanta | 1994 |
[Studies on the establishment of malarial animal model of short-term relapse. IV. Short-term relapse in rhesus monkeys infected with sporozoites of Plasmodium cynomolgi].
Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Disease Models, Animal; Drug Therapy, | 1993 |
Travellers' malaria risks.
Topics: Africa, Western; Chloroquine; Humans; Malaria; Mefloquine; Proguanil; Travel; United Kingdom | 1994 |
Antimalarial chemoprophylaxis for west Africa.
Topics: Africa, Western; Antimalarials; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Mefloquine; | 1993 |
Malaria chemoprophylaxis.
Topics: Chloroquine; Drug Combinations; Humans; Malaria; Mefloquine; Patient Compliance; Proguanil; Risk Fac | 1993 |
Malaria chemoprophylaxis.
Topics: Africa, Eastern; Africa, Western; Chloroquine; Drug Combinations; Humans; Malaria; Mefloquine; Patie | 1993 |
[Chloroquine].
Topics: Arthritis; Chloroquine; Humans; Liver Abscess, Amebic; Lupus Erythematosus, Systemic; Malaria | 1994 |
The chemotherapy of rodent malaria. LI. Studies on a new 8-aminoquinoline, WR 238,605.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; | 1993 |
Malaria chemosuppression during pregnancy. VI. Some epidemiological aspects of malaria in infants.
Topics: Age Factors; Chloroquine; Cohort Studies; Drug Therapy, Combination; Female; Follow-Up Studies; Huma | 1994 |
[Studies on the establishment of malarial animal model of short-term relapse. III. Combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance].
Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Disease Models, Animal; Drug Therapy, | 1993 |
Chloroquine induced mania.
Topics: Adolescent; Adult; Bipolar Disorder; Chloroquine; Combined Modality Therapy; Drug Therapy, Combinati | 1993 |
In vivo activity of ajoene against rodent malaria.
Topics: Animals; Chloroquine; Disulfides; Drug Synergism; Female; Malaria; Mice; Mice, Inbred BALB C; Plant | 1994 |
[Reactivation of hepatitis B following withdrawal of chloroquine].
Topics: Adult; Arthritis, Rheumatoid; Chloroquine; Female; Hepatitis B; Hepatitis B Core Antigens; Hepatitis | 1994 |
A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, west Africa. 6. The impact of the interventions on mortality and morbidity from malaria.
Topics: Antimalarials; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Gambia; Humans; Hygiene; I | 1993 |
The epidemiology of malaria in southern Sierra Leone.
Topics: Child; Child, Preschool; Chloroquine; Comorbidity; Cross-Sectional Studies; Female; Fever; Hematocri | 1993 |
Chloroquine retinopathy in Nigerian patients with heart block.
Topics: Adult; Aged; Aged, 80 and over; Chloroquine; Female; Heart Block; Humans; Malaria; Male; Middle Aged | 1993 |
Management of malaria in Zanzibar.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Clinical Protocols; Drug Administration Sch | 1993 |
Phagocytosis of malaria-infected erythrocytes in rodent malaria.
Topics: Animals; Chloroquine; Erythrocytes; Malaria; Mice; Mice, Inbred BALB C; Phagocytosis; Plasmodium ber | 1993 |
Malaria prophylaxis. Mefloquine should be first choice.
Topics: Chloroquine; Humans; Malaria; Mefloquine; Proguanil | 1993 |
On the question of interindividual variations in chloroquine concentrations.
Topics: Adult; Child; Chloroquine; Drug Monitoring; Humans; Malaria; Rheumatic Diseases | 1993 |
The China I/CDC strain of Plasmodium malariae in Aotus monkeys and chimpanzees.
Topics: Aged; Animals; Aotus trivirgatus; China; Chloroquine; Female; Humans; Malaria; Male; Pan troglodytes | 1994 |
[Outbreak of malaria induced among users of injectable drugs].
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Brazil; Child; Chloroquine; Cocaine; Disease | 1993 |
Warning--misleading malaria advice.
Topics: Chloroquine; Health Education; Humans; Malaria; Mefloquine; Pamphlets; Proguanil; South Africa | 1993 |
Malaria prophylaxis and treatment.
Topics: Botswana; Chloroquine; Humans; Malaria; Pyrimethamine; Zimbabwe | 1993 |
Counseling the international traveler. Update '93.
Topics: Antimalarials; Chloroquine; Cholera Vaccines; Counseling; Diarrhea; Humans; Immunization; Malaria; P | 1993 |
Chloroquine.
Topics: Child; Chloroquine; Humans; Malaria; Tablets; Tanzania | 1993 |
Control of heme polymerase by chloroquine and other quinoline derivatives.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Erythrocytes; Kinetics; Malar | 1993 |
Antimalarial activity of azithromycin and erythromycin against Plasmodium berghei.
Topics: Animals; Antiprotozoal Agents; Azithromycin; Chloroquine; Dose-Response Relationship, Drug; Drug Int | 1993 |
Malaria: impact of a standardized protocol on inpatient management.
Topics: Chloroquine; Clinical Protocols; Drug Resistance; Hospitalization; Hospitals, District; Humans; Keny | 1993 |
[Response to the previous comments by P. M. Shah].
Topics: Animals; Chloroquine; Humans; Malaria; Plasmodium; Primaquine | 1993 |
Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo.
Topics: Animals; Antimalarials; Aotus trivirgatus; Artemether; Artemisinins; Chloroquine; Disease Models, An | 1993 |
Hemoglobin catabolism and host-parasite heme balance in chloroquine-sensitive and chloroquine-resistant Plasmodium berghei infections.
Topics: Analysis of Variance; Animals; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemoglobins; Host-P | 1993 |
Chloroquine in malaria. Isn't it time for revision of prophylaxis schedules?
Topics: Chloroquine; Clinical Protocols; Drug Administration Schedule; Female; Humans; Malaria; Male; Sweden | 1993 |
Effect of chloroquine on hepatic heme-oxygenase during Plasmodium berghei infection in mice.
Topics: Animals; Chloroquine; Heme; Heme Oxygenase (Decyclizing); Liver; Malaria; Mice; Microsomes, Liver; P | 1993 |
A 54-kDa protein overexpressed by chloroquine-resistant Plasmodium berghei ANKA strain.
Topics: Animals; Chloroquine; Drug Resistance; Immune Sera; Immunoblotting; Malaria; Male; Mice; Plasmodium | 1993 |
Sensitivity of Plasmodium falciparum to chloroquine in pregnant women in Zaria, northern Nigeria.
Topics: Animals; Chloroquine; Drug Resistance; Female; Hospitals, General; Humans; In Vitro Techniques; Mala | 1993 |
Reversal of chloroquine resistance in murine malaria parasites by prostaglandin derivatives.
Topics: Alprostadil; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Malari | 1993 |
Evaluation of resistant-reversal, CDRI compound 87/209 and its possible mode of action in rodent experimental malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Heme; Heme Oxygenase (Decyclizing); | 1995 |
Human pharmacokinetics of chloroquine and proguanil delivered in a single capsule for malaria chemoprophylaxis.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Female; Humans; Mal | 1995 |
The chemotherapy of rodent malaria. L. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 3: Observations on 'Fenozan-50F', a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Malaria; Mice; Peroxides; Plasmodium; Spiro Co | 1993 |
Malaria in a rural area of Sierra Leone. I. Initial results.
Topics: Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Infant, Newborn; Malaria; Male; Sierra | 1993 |
Canadian recommendations for the prevention and treatment of malaria among international travellers. Committee to Advise on Tropical Medicine and Travel (CATMAT).
Topics: Animals; Antimalarials; Canada; Child; Chloroquine; Culicidae; Drug Resistance; Female; Humans; Mala | 1995 |
Plasmodium berghei: sensitivity of chloroquine-resistant and chloroquine-sensitive strains to irradiation and the effect of irradiated malaria parasites on cytochrome P450-dependent monooxygenases.
Topics: Alanine Transaminase; Animals; Antimalarials; Aspartate Aminotransferases; Chloroquine; Drug Resista | 1995 |
Post-transfusion acquired malaria complicating orthotopic liver transplantation.
Topics: Animals; Antimalarials; Chloroquine; Female; Humans; Liver Transplantation; Malaria; Middle Aged; Pl | 1996 |
Chloroquine ototoxicity: an idiosyncratic phenomenon.
Topics: Audiometry, Pure-Tone; Child, Preschool; Chloroquine; Hearing Loss, Sensorineural; Humans; Injection | 1996 |
Toward a novel metal-based chemotherapy against tropical diseases. 2. Synthesis and antimalarial activity in vitro and in vivo of new ruthenium- and rhodium-chloroquine complexes.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Magnetic Resonance Spectroscopy; Malar | 1996 |
The effect of some 2-substituted quinolines isolated from Galipea longiflora on Plasmodium vinckei petteri infected mice.
Topics: Animals; Antimalarials; Bolivia; Chloroquine; Malaria; Mice; Mice, Inbred BALB C; Plant Extracts; Pl | 1996 |
The iron environment in heme and heme-antimalarial complexes of pharmacological interest.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Heme; Hemeproteins; Hemin; Humans; Ir | 1996 |
Antimalarial properties of soy-bean fat emulsions.
Topics: Animals; Antimalarials; Chloroquine; Fat Emulsions, Intravenous; Female; Glycine max; Humans; Malari | 1995 |
Chloroquine pruritus: a possible fixed cutaneous reaction.
Topics: Antimalarials; Chloroquine; Drug Eruptions; Female; Humans; Malaria; Male; Pruritus; Skin | 1996 |
Unreliability of saliva samples for monitoring chloroquine and proguanil levels during anti-malarial chemoprophylaxis.
Topics: Antimalarials; Chloroquine; Drug Monitoring; Drug Therapy, Combination; Humans; Malaria; Proguanil; | 1996 |
Malaria in São Tomé and Principe: prevalence and drug-susceptibility.
Topics: Africa, Western; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Parasitemia; Prevalen | 1996 |
[Informal care of malaria: determinants of demand and supply inventory. A study conducted in Touba City (Senegal)].
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Female; Health Care Costs; Humans; Malaria; Male; Mef | 1996 |
Antimalarial activity of novel arylene bis(methylketone) compounds.
Topics: Animals; Antimalarials; Chloroquine; Female; Malaria; Mice; Mice, Inbred Strains; Molecular Structur | 1996 |
Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers.
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Health Surveys; Hospitalizatio | 1996 |
Prevalence of malaria parasitaemia in transfused donor blood in Benin City, Nigeria.
Topics: Animals; Blood-Borne Pathogens; Chi-Square Distribution; Chloroquine; Humans; Infant, Newborn; Malar | 1996 |
4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; | 1996 |
Carboxylic ionophores in malaria chemotherapy: the effects of monensin and nigericin on Plasmodium falciparum in vitro and Plasmodium vinckei petteri in vivo.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Malaria; Mice; Monensin; Nige | 1996 |
Status of chloroquine resistance in Plasmodium falciparum in Tripura.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; I | 1995 |
Outcome of admitted malaria cases by treatment at Manicaland Provincial Hospital, Zimbabwe.
Topics: Adolescent; Adult; Age Distribution; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Ho | 1996 |
Amodiaquine.
Topics: Africa South of the Sahara; Amodiaquine; Antimalarials; Chloroquine; Drug Resistance; Health Policy; | 1996 |
Induction of chloroquine resistance in Plasmodium yoelii nigeriensis.
Topics: Animals; Antimalarials; Body Weight; Chloroquine; Disease Models, Animal; Drug Resistance; Female; M | 1996 |
Efficacy of Cymbopogon giganteus and Enantia chrantha against chloroquine resistant Plasmodium yoelii nigeriensis.
Topics: Animals; Chloroquine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistanc | 1996 |
Protean manifestations of malaria--(multi organ dysfunction syndrome).
Topics: Adult; Antimalarials; Cardiomyopathies; Chloroquine; Diagnosis, Differential; Drug Resistance, Micro | 1996 |
Chloroquine bioassay of plasma specimens obtained from soldiers on chloroquine plus doxycycline for malaria prophylaxis.
Topics: Antimalarials; Australia; Biological Assay; Chloroquine; Chromatography, High Pressure Liquid; Doxyc | 1996 |
Depolymerization of malarial hemozoin: a novel reaction initiated by blood schizontocidal antimalarials.
Topics: Animals; Antimalarials; Chloroquine; Heme; Hemeproteins; Hemoglobins; Kinetics; Malaria; Mice; Model | 1997 |
The chemotherapy of rodent malaria. LIV. Combinations of 'Fenozan B07' (Fenozan-50F), a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane, with other drugs against drug-sensitive and drug-resistant parasites.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Antagonism; Drug Resistance; Drug Synergi | 1997 |
Malaria in differing guises.
Topics: Adult; Antimalarials; Australia; Chloroquine; Humans; Malaria; Male; Risk Factors; Travel | 1997 |
[Not more symptoms with mefloquine use than with other drugs in malaria prophylaxis].
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Humans; Malaria; M | 1997 |
The pharmacokinetics of chloroquine in healthy and Plasmodium chabaudi-infected mice: implications for chronotherapy.
Topics: Animals; Antimalarials; Chloroquine; Circadian Rhythm; Disease Models, Animal; Injections, Intraperi | 1994 |
Plasmodium yoelii nigeriensis: biological mechanisms of resistance to chloroquine.
Topics: Animals; Antimalarials; Centrifugation, Density Gradient; Chloroquine; Drug Resistance; Injections, | 1994 |
Multi-drug resistant malaria in Sri Lanka.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance, Multiple; Humans; Ma | 1996 |
Adaptive changes in Plasmodium transmission strategies following chloroquine chemotherapy.
Topics: Adaptation, Biological; Animals; Antimalarials; Chloroquine; Humans; Malaria; Male; Mice; Mice, Inbr | 1997 |
Characterization of simian malarial parasite (Plasmodium knowlesi)-induced putrescine transport in rhesus monkey erythrocytes. A novel putrescine conjugate arrests in vitro growth of simian malarial parasite (Plasmodium knowlesi) and cures multidrug resis
Topics: Aminoquinolines; Animals; Antimalarials; Biological Transport, Active; Chloroquine; Drug Resistance, | 1997 |
Seasonality, malaria, and impact of prophylaxis in a West African village I. Effect of anemia in pregnancy.
Topics: Adolescent; Adult; Anemia; Antimalarials; Censuses; Chloroquine; Cross-Sectional Studies; Female; He | 1997 |
Seasonality, malaria, and impact of prophylaxis in a West African village. II. Effect on birthweight.
Topics: Adult; Antimalarials; Birth Weight; Chloroquine; Cross-Sectional Studies; Female; Hematocrit; Humans | 1997 |
[Chloroquine resistance and prophylaxis].
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria | 1997 |
Toward a novel metal-based chemotherapy against tropical diseases. 3. Synthesis and antimalarial activity in vitro and in vivo of the new gold-chloroquine complex [Au(PPh3)(CQ)]PF6.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Malaria; Mice; Mice, Inbred BALB C; Mo | 1997 |
Malaria-related beliefs and behaviour in southern Ghana: implications for treatment, prevention and control.
Topics: Antimalarials; Behavior; Child; Child Care; Chloroquine; Communicable Disease Control; Disease Trans | 1997 |
Chloroquine blood concentrations and malaria prophylaxis in Tanzanian women during the second and third trimesters of pregnancy.
Topics: Adult; Area Under Curve; Chloroquine; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, P | 1997 |
Proteasome inhibitors in development for malaria.
Topics: Africa; Animals; Boronic Acids; Chloroquine; Cysteine Endopeptidases; Dipeptides; Drug Resistance; M | 1997 |
Malaria fighters gather at site of early victory.
Topics: Acquired Immunodeficiency Syndrome; Africa; Animals; Animals, Genetically Modified; Anopheles; Antim | 1997 |
Malaria prophylaxis prescribed for travellers from New Zealand.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Utilization; Humans; Malaria; New Zeala | 1997 |
Compliance with and tolerance of mefloquine and chloroquine + proguanil malaria chemoprophylaxis in French short-term travellers to sub-Saharan Africa.
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Humans; Kenya; Malaria; Male; | 1997 |
Update on prevention of malaria for travelers.
Topics: Animals; Antimalarials; Chloroquine; Doxycycline; Drug Resistance; Global Health; Guidelines as Topi | 1997 |
Pediatric malaria in Houston, Texas.
Topics: Adolescent; Adult; Anemia; Child; Child, Preschool; Chloroquine; Female; Hospitals, Teaching; Humans | 1997 |
[Malaria attacks after returning from endemic areas. Failure or inadequate chemoprophylaxis?].
Topics: Adolescent; Adult; Aged; Antimalarials; Chemoprevention; Chloroquine; Drug Resistance; Endemic Disea | 1997 |
Polyamine metabolism in various tissues during pathogenesis of chloroquine-susceptible and resistant malaria.
Topics: Adenosylmethionine Decarboxylase; Animals; Antimalarials; Brain; Chloroquine; Drug Resistance; Eryth | 1997 |
Malaria: an unresolved problem.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; History, 19th Century; History, 20t | 1997 |
A role for B cells in the development of T cell helper function in a malaria infection in mice.
Topics: Animals; B-Lymphocytes; Chloroquine; Erythrocytes; Female; Genes, Immunoglobulin; Immunoglobulin mu- | 1998 |
Knowledge and misconceptions about malaria among secondary school students and teachers in Kassala, eastern Sudan.
Topics: Abortifacient Agents; Abortion, Spontaneous; Adolescent; Adult; Age Factors; Antimalarials; Beverage | 1997 |
Plasmodium berghei: in vivo efficacy of albendazole in different rodent models.
Topics: Albendazole; Animals; Anthelmintics; Antimalarials; Biomarkers; Chloroquine; Chromium Compounds; Dis | 1998 |
Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Enzyme Inhibitors; Heme Oxygenase (Decyclizing | 1998 |
[Malaria drug for African poor in sight].
Topics: Africa; Animals; Antimalarials; Chloroquine; Developing Countries; Drug Resistance; Humans; Malaria; | 1998 |
High-level chloroquine resistance of Plasmodium berghei is associated with multiple drug resistance and loss of reversal by calcium antagonists.
Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Drug Resistance; Drug Resistance, Mul | 1998 |
The role of chemotherapy in early malaria control and eradication programmes in Thailand.
Topics: Antimalarials; Child; Chloroquine; DDT; Drug Resistance; History, 20th Century; Humans; Malaria; Mos | 1998 |
Mefloquine to prevent malaria. Withdrawal rates are misleading measure of tolerability.
Topics: Anti-Bacterial Agents; Antimalarials; Chloroquine; Doxycycline; Humans; Malaria; Mefloquine; Proguan | 1998 |
[Chemoprophylaxis of malaria in travelers to endemic zones].
Topics: Antimalarials; Chloroquine; Dapsone; Doxycycline; Drug Resistance; Drug Therapy, Combination; Humans | 1998 |
Studies on malaria during pregnancy in a tribal area of central India (Madhya Pradesh).
Topics: Adult; Antimalarials; Chloroquine; Female; Fever; Hemoglobins; Humans; India; Malaria; Malaria, Falc | 1998 |
Use of antimalarial drugs in Mali: policy versus reality.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Consumer Behavior; Data Collection; Drug Combinations | 1998 |
Malaria disaster in Africa.
Topics: Africa; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria | 1998 |
Pustular eruption in a malaria patient treated with chloroquine.
Topics: Adult; Antimalarials; Chloroquine; Drug Eruptions; Female; Humans; Malaria; Skin Diseases, Vesiculob | 1998 |
Chemoprophylaxis compliance in travelers with malaria.
Topics: Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Female; Humans; Malaria; Male; Pat | 1998 |
Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Adverse Drug Reaction Reporting Systems; | 1998 |
Adverse effects of antimalarial prophylactic drugs: an important consideration in the risk-benefit equation.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Atovaquone; Azithromycin; Chloroquine; Drug Therapy, | 1998 |
[Evaluation of malaria chemoprevention among 359 pregnant women attending a health center in Dakar].
Topics: Adolescent; Adult; Antimalarials; Chemoprevention; Chloroquine; Female; Humans; Malaria; Maternal He | 1997 |
Malaria at Christmas: risks of prophylaxis versus risks of malaria.
Topics: Adult; Antimalarials; Chloroquine; Disease Outbreaks; Female; Humans; Malaria; Male; Mefloquine; Mid | 1998 |
Science commentary: protection against malaria.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Mefloquine; Proguanil; Travel | 1998 |
Therapy with a combination of low doses of interleukin 12 and chloroquine completely cures blood-stage malaria, prevents severe anemia, and induces immunity to reinfection.
Topics: Anemia; Animals; Antibodies, Protozoan; Antimalarials; Chloroquine; Disease Models, Animal; Drug The | 1999 |
A severe adverse reaction to mefloquine and chloroquine prophylaxis.
Topics: Adult; Antimalarials; Chloroquine; Drug Hypersensitivity; Humans; Malaria; Male; Mefloquine; Severit | 1998 |
Malaria and anaemia at different altitudes in the Muheza district of Tanzania: childhood morbidity in relation to level of exposure to infection.
Topics: Altitude; Anemia; Animals; Anopheles; Antimalarials; Child, Preschool; Chloroquine; Humans; Infant; | 1998 |
[The proper use of antimalarial drugs currently available].
Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Contraindications; Drug Combinations; Drug Res | 1998 |
Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei.
Topics: Animals; Antimalarials; Buthionine Sulfoximine; Chloroquine; Drug Resistance; Glutathione; Glutathio | 1999 |
[Drug resistance of Plasmodium falciparum along the borders of the highlands in Madagascar: outlook for a national control program].
Topics: Animals; Antimalarials; Chloroquine; Communicable Disease Control; Drug Resistance, Microbial; Human | 1998 |
The use of formal and informal services for antenatal care and malaria treatment in rural Uganda.
Topics: Adult; Antimalarials; Chloroquine; Communication Barriers; Developing Countries; Female; Health Educ | 1998 |
Malaria prophylaxis for the 1990s and beyond.
Topics: Antimalarials; Atovaquone; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; | 1997 |
[Sale of chloroquine in the street in Niamey (Niger)].
Topics: Chloroquine; Humans; Malaria; Niger; Self Medication | 1999 |
Antimalarial herbs against chloroquine-resistant P. yoelii nigeriensis in mice.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Malaria; Mice; Plant Extracts; Plants, Medicin | 1998 |
Plasmodium chabaudi chabaudi: effect of low parasitemias on immunity in CB6F1 mice.
Topics: Animals; Antibodies, Protozoan; Antimalarials; Chloroquine; Female; Malaria; Male; Mice; Parasitemia | 1999 |
Studies on hepatic oxidative stress and antioxidant defence system during chloroquine/poly ICLC treatment of Plasmodium yoelii nigeriensis infected mice.
Topics: Animals; Antimalarials; Antioxidants; Carboxymethylcellulose Sodium; Chloroquine; Glutathione; Gluta | 1999 |
Changing home treatment of childhood fevers by training shop keepers in rural Kenya.
Topics: Analgesics, Non-Narcotic; Antimalarials; Child; Chloroquine; Community Pharmacy Services; Drug Infor | 1999 |
Chloroquine sensitivity confirmed.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Zimbabwe | 1999 |
The rising incidence of serious chloroquine overdose in Harare, Zimbabwe: emergency department surveillance in the developing world.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Developing Countries; Drug Overdose; Emergency Servic | 1999 |
Blue nails are a sign of HIV infection.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Fatal Outcome; Female; | 1999 |
Plasmodium falciparum mdr1 mutations and in vivo chloroquine resistance in Indonesia.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Chromatography, High Pressur | 1999 |
Plasmodium chabaudi: effect of antimalarial drugs on gametocytogenesis.
Topics: Animals; Antimalarials; Chloroquine; Gametogenesis; Malaria; Male; Mefloquine; Mice; Mice, Inbred C5 | 1999 |
Plasmodium berghei: a new rat model for assessment of blood schizonticidal activity.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Eryth | 1999 |
[Late treatment: main severity factor in flare-up of P. falciparum infection].
Topics: Animals; Antimalarials; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Plasmodium falcipar | 1999 |
[Prevention of malaria].
Topics: Anti-Bacterial Agents; Antimalarials; Chloroquine; Doxycycline; Female; Humans; Malaria; Malaria, Fa | 1999 |
Imported malaria: successful treatment of 31 patients in the era of chloroquine resistance.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Chloroquine; Drug Resistance; Fem | 1999 |
The effect of chloroquine on the production of interferon-gamma, interleukin (IL)-4, IL-6, and IL-10 in Plasmodium chabaudi chabaudi in infected C57BL6 mice.
Topics: Animals; Antimalarials; Chloroquine; Female; Interferon-gamma; Interleukin-10; Interleukin-4; Interl | 1999 |
Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Azithromycin; Chloroquine; Doxycycline; Erythromycin; | 2000 |
Development of irreversible lesions in the brain, heart and kidney following acute and chronic murine malaria infection.
Topics: Acute Disease; Animals; Antimalarials; Brain; Chloroquine; Chronic Disease; Kidney; Malaria; Mice; M | 1999 |
Schizontocidal effects of oral artesunate on Plasmodium berghei in mice and P knowlesi in monkeys.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Erythrocytes; Female; Macaca mulatta; | 1999 |
Prevention of malaria.
Topics: Antimalarials; Chloroquine; Doxycycline; Drug Resistance; Humans; Malaria; Mefloquine | 2000 |
Malaria control in central Malaita, Solomon Islands 2. Local perceptions of the disease and practices for its treatment and prevention.
Topics: Animals; Antimalarials; Attitude to Health; Caregivers; Child; Child, Preschool; Chloroquine; Culici | 2000 |
Immune responses to chloroquine--sensitive and resistant populations of Plasmodium berghei in mice.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Lymphocyte Activation; Malaria; Mice; Mice, In | 1999 |
Therapy and drug resistance in malaria.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; In | 2000 |
Unexplained fever-analysis of 233 cases in a referral hospital.
Topics: Adult; Antimalarials; Bacterial Infections; Chloroquine; Diagnosis, Differential; Female; Fever of U | 1999 |
[Malaria imported to Norway 1989-98].
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Disease Notification; | 2000 |
[Therapeutic efficacy of different antimalarial regimens in the Costa Rica-Nicaragua border region].
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Costa Rica; Humans; Malaria; Middle Aged; Nicaragua; | 2000 |
The contributions of various chloroquine salts to the biliary and urinary execretion of hepatic paracetamol conjugation metabolites in the rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Bile; Chloroquine; Drug Interaction | 2000 |
Imported malaria: a retrospective study in University Hospital, Kuala Lumpur, a ten-year experience.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chloroquine; Emigration and Immigration; Female; H | 1998 |
Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum.
Topics: Alleles; Animals; Antimalarials; Chloroquine; Drug Resistance; Genes, Protozoan; Humans; Malaria; Pa | 2000 |
Oxygenated chalcones and bischalcones as potential antimalarial agents.
Topics: Animals; Antimalarials; Chalcone; Chloroquine; Drug Design; Drug Resistance; Malaria; Male; Mice; Mo | 2000 |
Mechanisms of chloroquine-induced pruritus.
Topics: Animals; Chloroquine; Humans; Malaria; Mice; Pruritus; Rats | 2000 |
Malaria in a Trinidadian man.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Male; Plasmodium malariae; Primaquine; Seconda | 2000 |
The effects of subcurative doses of chloroquine on Plasmodium vinckei petteri gametocytes and on their infectivity to mosquitoes.
Topics: Animals; Anopheles; Anthelmintics; Chloroquine; Drug Resistance; Malaria; Male; Mice; Parasitemia; P | 2000 |
Canadian recommendations for the prevention and treatment of malaria among international travellers. Committee to Advise on Tropical Medicine and Travel CATMAT), Laboratory for Disease Control.
Topics: Animals; Antimalarials; Canada; Chloroquine; Humans; Malaria; Plasmodium malariae; Risk Factors; Tra | 2000 |
Is one gene the key to chloroquine-resistant malaria?
Topics: Animals; Chloroquine; Drug Resistance; Malaria; Plasmodium falciparum | 2000 |
Patterns of care for childhood malaria in Zambia.
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Female; Fever; Health Care Surveys; | 2000 |
Interaction between chloroquine and diverse pharmacological agents in chloroquine resistant Plasmodium yoelii nigeriensis.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Malaria; Ma | 2000 |
A role for linoleic acid in erythrocytes infected with Plasmodium berghei.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Erythrocytes; Fatty Acids, Nonesterified; Fatt | 2000 |
Using evidence to change antimalarial drug policy in Kenya.
Topics: Antimalarials; Chloroquine; Drug Resistance; Evidence-Based Medicine; Health Policy; Humans; Kenya; | 2000 |
The chemotherapy of rodent malaria. LIX. Drug combinations to impede the selection of drug resistance, Part 3: Observations on cyproheptadine, an antihistaminic agent, with chloroquine.
Topics: Animals; Antimalarials; Chloroquine; Cyproheptadine; Dose-Response Relationship, Drug; Drug Combinat | 2000 |
Child malaria treatment practices among mothers in the district of Yanfolila, Sikasso region, Mali.
Topics: Adult; Antimalarials; Child, Preschool; Chloroquine; Female; Health Knowledge, Attitudes, Practice; | 2000 |
Roll back malaria: technically feasible or just politically correct?
Topics: Africa; Antimalarials; Chloroquine; Global Health; Humans; Insecticide Resistance; International Coo | 2000 |
Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity.
Topics: Antimalarials; Child; Chloroquine; Drug Overdose; Drug Synergism; Drug Therapy, Combination; Humans; | 2001 |
Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice.
Topics: Animals; Antimalarials; Artemisinins; Carbolines; Chloroquine; Dose-Response Relationship, Drug; Mal | 2000 |
[Malaria and pregnancy: attitude of health care personnel during prenatal care in Cotonou, Benin].
Topics: Antimalarials; Attitude of Health Personnel; Benin; Chloroquine; Female; Health Policy; Humans; Mala | 2000 |
Assessment of the antimalarial potential of tetraoxane WR 148999.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Cytochrome P-450 Enzyme Inhibitors; Drug Interact | 2000 |
[Does the brief treatment with antimalarials favorably influence drug resistance and recurrences?].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Malaria, | 2001 |
Aminonaphthoquinones--a novel class of compounds with potent antimalarial activity against Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Mala | 2001 |
Analysis of the PfCRT K76T mutation in Plasmodium falciparum isolates from the Amazon region of Brazil.
Topics: Animals; Antimalarials; Biomarkers; Brazil; Chloroquine; Disease Outbreaks; Drug Resistance; Humans; | 2001 |
Malaria deaths following inappropriate malaria chemoprophylaxis--United States, 2001.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Middle Aged | 2001 |
Antimalarial in-vivo activity of bis(9-amino-6-chloro-2-methoxyacridines).
Topics: Aminoacridines; Animals; Antimalarials; Chloroquine; Female; Malaria; Mice; Plasmodium berghei | 2001 |
Knowledge and management of malaria in under five children by primary health care workers in Ibadan South-east local government area.
Topics: Adult; Case Management; Child, Preschool; Chloroquine; Community Health Workers; Cross-Sectional Stu | 2001 |
Malaria prophylaxis and the reduction of anemia at childbirth.
Topics: Anemia; Animals; Antimalarials; Birth Weight; Case-Control Studies; Chloroquine; Female; Ghana; Hemo | 2001 |
From the Centers for Disease Control and Prevention. Malaria deaths following inappropriate malaria chemoprophylaxis--United States, 2001.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Middle Aged | 2001 |
Treatment of childhood fevers and other illnesses in three rural Nigerian communities.
Topics: Anti-Bacterial Agents; Antimalarials; Child; Child, Preschool; Chloroquine; Cough; Female; Fever; He | 2001 |
Antimalarial drugs clear resistant parasites from partially immune hosts.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Immunization; Malaria; | 2001 |
Potent antimalarial activities of polyether antibiotic, X-206.
Topics: Actinomycetales; Animals; Anti-Bacterial Agents; Antimalarials; Artemether; Artemisinins; Artesunate | 2001 |
A comparison of the stage-specific efficacy of chloroquine, artemether and dioncophylline B against the rodent malaria parasite Plasmodium chabaudi chabaudi in vivo.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Female; Isoquinolines; Life Cycle Sta | 2001 |
Synthesis of new arylaminoquinoxalines and their antimalarial activity in mice.
Topics: Animals; Antimalarials; Chloroquine; Indicators and Reagents; Malaria; Mannich Bases; Mice; Plasmodi | 2001 |
Monitoring antimalarial drug resistance within National Malaria Control Programmes: the EANMAT experience.
Topics: Africa, Eastern; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Geography; Health C | 2001 |
Case report: Retinopathy after malaria prophylaxis with chloroquine.
Topics: Antimalarials; Chloroquine; Female; Humans; Malaria; Middle Aged; Retinal Diseases | 2001 |
Malaria control in Bungoma District, Kenya: a survey of home treatment of children with fever, bednet use and attendance at antenatal clinics.
Topics: Antimalarials; Bedding and Linens; Child; Child Care; Chloroquine; Cluster Analysis; Communicable Di | 2001 |
Perception of chloroquine efficacy and alternative treatments for uncomplicated malaria in children in a holoendemic area of Tanzania: implications for the change of treatment policy.
Topics: Adolescent; Adult; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Endemic Diseases | 2001 |
Changing the first line drug for malaria treatment--cost-effectiveness analysis with highly uncertain inter-temporal trade-offs.
Topics: Africa South of the Sahara; Antimalarials; Case Management; Child; Child, Preschool; Chloroquine; Co | 2001 |
[Epileptic crisis after antimalaria chemoprophylaxis with chloroquine].
Topics: Anti-Anxiety Agents; Anticonvulsants; Antimalarials; Benzodiazepines; Chloroquine; Clobazam; Epileps | 2001 |
Malaria deaths following inappropriate malaria chemoprophylaxis--United States, 2001.
Topics: Antimalarials; Child; Chloroquine; Drug Therapy, Combination; Fatal Outcome; Humans; Malaria; Middle | 2002 |
Short-term effect of chloroquine on the infectivity of Plasmodium chabaudi gametocytes.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Female; Life Cycle Stages; Malaria; Mice; Oocytes; P | 2001 |
A double-headed pro-drug that overcomes chloroquine resistance.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Enzyme Inhibitors; Glutathione; Glutathione Re | 2002 |
African scientists discuss drug-resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance, Multiple; Drug Therapy, Com | 2002 |
[Malaise after a trip to Africa: amoebic liver abscess].
Topics: Adult; Antimalarials; Chloroquine; Diagnosis, Differential; Humans; Kenya; Liver Abscess, Amebic; Ma | 2002 |
Case management of malaria in under-fives at primary health care facilities in a Tanzanian district.
Topics: Anti-Bacterial Agents; Antimalarials; Case Management; Child, Preschool; Chloroquine; Chromatography | 2002 |
Changes in schizogony and drug response in two lines of rodent Plasmodium, P. berghei NK 65 and P. berghei ANKA.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Malaria; Mice; Muridae; Plasmodium ber | 2002 |
Appropriate treatment of malaria? Use of antimalarial drugs for children's fevers in district medical units, drug shops and homes in eastern Uganda.
Topics: Administration, Oral; Antimalarials; Caregivers; Child Health Services; Child, Preschool; Chloroquin | 2002 |
Amodiaquine: the exempted antimalarial drug in Ethiopia.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Ethiopia; Humans; Malaria; Plasmo | 1998 |
Syncope following oral chloroquine administration in a hypertensive patient controlled on amlodipine.
Topics: Administration, Oral; Amlodipine; Chloroquine; Drug Synergism; Humans; Hypertension; Malaria; Male; | 2002 |
Advice for travelers.
Topics: Africa; Altitude Sickness; Asia; Chloroquine; Ciprofloxacin; Contraindications; Diarrhea; Female; He | 2002 |
Synthesis of ferroquine enantiomers: first investigation of effects of metallocenic chirality upon antimalarial activity and cytotoxicity.
Topics: Animals; Antimalarials; Cell Division; Chloroquine; Female; Ferric Compounds; In Vitro Techniques; M | 2002 |
[Which medication should be used to treat uncomplicated malaria when chloroquine becomes ineffective in Western Côte d'Ivoire?].
Topics: Antimalarials; Child, Preschool; Chloroquine; Cote d'Ivoire; Humans; Malaria; Treatment Failure | 2002 |
Acute acalculous cholecystitis associated with co-infection by Plasmodium falciparum and Plasmodium vivax.
Topics: Animals; Antimalarials; Chloroquine; Cholecystitis; Female; Humans; Malaria; Middle Aged; Plasmodium | 2002 |
[Accumulation and effluxion of chloroquine in chloroquine-sensitive and chloroquine-resistant Plasmodium berghei].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Malaria; Mice; Plasmodium berghe | 1998 |
Development of effective antisporozoite immunity by natural bites of Plasmodium-berghei-infected mosquitoes in rats under prophylactic treatment with various drug regimens.
Topics: Animals; Antibodies; Chloroquine; Cross Reactions; Culicidae; Malaria; Plasmodium berghei; Primaquin | 1978 |
Letter: Chloroguine and HBs-Ag carrier status.
Topics: Carrier State; Chloroquine; Hepatitis B; Hepatitis B Antigens; Humans; Malaria; Radioimmunoassay | 1975 |
Drug sensitivity of plasmodium falciparum. An in-vitro microtechnique.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Haplorhini; Humans; In Vitro Techniques; Malaria; | 1978 |
Persistence of drug-resistant malaria parasites.
Topics: Animals; Chloroquine; Drug Resistance; Malaria; Mice; Mutation; Plasmodium; Pyrimethamine | 1978 |
Weekly malaria prophylaxis: 300 or 600 mg chloroquine base.
Topics: Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Time Factors | 1979 |
Antimalarial activities of various 4-quinolonemethanols with special attention to WR-142,490 (mefloquine).
Topics: Administration, Oral; Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Therap | 1978 |
Plasmodium falciparum and Plasmodium vivax infections in the owl monkey (Aotus trivirgatus). II. Responses to chloroquine, quinine, and pyrimethamine.
Topics: Animals; Aotus trivirgatus; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; F | 1978 |
Antimalarial activities of various 9-phenanthrenemethanols with special attention to WR-122,455 and WR-171,669.
Topics: Animals; Antimalarials; Chloroquine; Haplorhini; Humans; Malaria; Phenanthrenes; Plasmodium falcipar | 1978 |
[An epidemiological consideration of the status of infection in 29 patients with malaria (author's transl)].
Topics: Adult; Aged; Chloroquine; Female; Humans; Japan; Malaria; Male; Middle Aged; Plasmodium falciparum; | 1978 |
Studies on the 2,4-diamino-6-substituted quinazolines. II. Activities of selected derivatives against infections with various drug-susceptible and drug-resistant strains of Plasmodium falciparum and Plasmodium vivax in owl monkeys.
Topics: Animals; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance, Microbial; | 1979 |
Plasmodium fragile and Macaca mulatta monkeys as a model system for the study of malaria vaccines.
Topics: Animals; Antibody Formation; Chloroquine; Disease Models, Animal; Haplorhini; Macaca mulatta; Malari | 1979 |
Antimalarial properties of floxacrine, a dihydroacridinedione derivative.
Topics: Acridines; Animals; Antimalarials; Chloroquine; Haplorhini; Macaca mulatta; Malaria; Plasmodium falc | 1979 |
Plasmodium berghei: suppression of antibody response to sporozoite stage by acute blood stage infection.
Topics: Acute Disease; Animals; Antibody Formation; Antibody Specificity; Apicomplexa; Chloroquine; Cricetin | 1979 |
[Chemotherapy in areas of persistent malaria transmission and resistence of Plasmodium falciparum to chloroquine in Panama].
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Panama; Plasmodium fa | 1975 |
Exotic diseases. Ounce of prevention or pound of cure?
Topics: Beverages; Chloroquine; Clioquinol; Diagnosis; Diarrhea; Drug Resistance, Microbial; Eosinophils; Fe | 1977 |
Resistance to antimalarials by Plasmodium falciparum in Burma.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Myanmar; Plasmodium falciparum; Pyrime | 1977 |
[Biological diagnosis of malaria and amebiasis].
Topics: Acetamides; Amebiasis; Chloroquine; Emetine; Entamoeba histolytica; Feces; Humans; Malaria; Methods; | 1977 |
[Chloroquine neuromyopathy. One case in prophylactic maleriatherapy (author's transl)].
Topics: Adult; Chloroquine; Humans; Malaria; Male; Muscles; Muscular Diseases; Peripheral Nervous System Dis | 1977 |
Effect of chloroquine on Epstein-Barr virus expression.
Topics: Antigens, Viral; Burkitt Lymphoma; Cells, Cultured; Chloroquine; Herpesvirus 4, Human; Humans; Malar | 1979 |
Malaria studies in vitro. IV: Chloroquine resistance and the intracellular pH of erythrocytes parasitised with Plasmodium berghei.
Topics: Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance; Erythrocytes; Hematocrit; Hydrogen-Ion | 1975 |
Aplasia and leukaemia following chloroquine therapy.
Topics: Adult; Anemia, Aplastic; Bone Marrow; Chloroquine; Female; Humans; Leukemia, Myeloid, Acute; Malaria | 1978 |
Where are you going.
Topics: Chloroquine; Female; Humans; Malaria; Plasmodium falciparum; Travel | 1977 |
Plasmodium vivax: correlation of circumsporozoite precipitation (CSP) reaction with sporozoite-induced protective immunity in man.
Topics: Adult; Anopheles; Antibodies; Chloroquine; Humans; Immunization; Malaria; Male; Plasmodium vivax; Pr | 1977 |
Plasmodium falciparum gametocytes: their longevity and infectivity.
Topics: Animals; Anopheles; Antibodies; Blood; Chloroquine; Humans; Malaria; Plasmodium falciparum | 1977 |
Chloroquine resistant Plasmodium falciparum in Bangladesh.
Topics: Bangladesh; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1976 |
Prevention and treatment of malaria.
Topics: Amodiaquine; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Pyrimethamine; Qu | 1977 |
Chloroquine-resistant Plasmodium falciparum and malaria in Africa.
Topics: Adolescent; Adult; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Ni | 1977 |
Plasmodium berghei: selective release of "protective" antigens.
Topics: Animals; Antibody Formation; Antigens; Chloroquine; Immune Sera; Immunity, Active; Immunization; Imm | 1977 |
Plasmodium berghei: immunosuppression and hyperimmunoglobulinemia.
Topics: Animals; Antibody Formation; Antigens; Chloroquine; Erythrocytes; Hypergammaglobulinemia; Immune Tol | 1977 |
Chemoprophylaxis of malaria.
Topics: Chloroquine; Hemoglobin, Sickle; Humans; Malaria; Plasmodium falciparum | 1977 |
[A patient with high fever].
Topics: Chloroquine; Fever; Humans; Indonesia; Malaria; Male; Middle Aged; Netherlands; Nigeria; Plasmodium | 1977 |
[Chloroquine resistant tropical malaria imported from Surinam].
Topics: Chloroquine; Drug Resistance; Female; Humans; Malaria; Middle Aged; Netherlands; Plasmodium falcipar | 1977 |
The prevention and treatment of malaria.
Topics: Adult; Australia; Child; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; | 1977 |
Plasmodium berghei: formation of secondary immune complexes in hyperimmune mice.
Topics: Animals; Antigen-Antibody Complex; Antigens; Chloroquine; Complement System Proteins; Immunoglobulin | 1977 |
Host heme catabolism in drug-sensitive and drug-resistant malaria.
Topics: Animals; Carbon Monoxide; Chloroquine; Drug Resistance; Heme; Malaria; Male; Mice; Plasmodium berghe | 1977 |
The prevention and treatment of malaria.
Topics: Africa; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1977 |
Malaria control in the labour forces of the Tan-Zam railway.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Malaria; Male; Midd | 1977 |
[Tertiary malaria with acute lung edema in a Turkish child].
Topics: Blood Transfusion; Child, Preschool; Chloroquine; Erythrocytes; Germany, West; Humans; Malaria; Male | 1977 |
Efficacy of 5-day radical treatment of P. vivax infection in Tamil Nadu.
Topics: Adult; Child; Chloroquine; Follow-Up Studies; Humans; India; Malaria; Plasmodium vivax; Primaquine; | 1977 |
Chloroquine susceptibility in malaria: dependence on exposure of parasites to the drug.
Topics: Animals; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Malaria; Male; Mice; Plasmo | 1977 |
Comparison of treatment schedules for Plasmodium vivax infections in the Solomon Islands.
Topics: Adolescent; Adult; Child; Chloroquine; Drug Administration Schedule; Female; Humans; Malaria; Male; | 1977 |
In vivo and in vitro studies of chloroquine-resistant malaria in Thailand.
Topics: Chloroquine; Drug Resistance, Microbial; Malaria; Plasmodium falciparum; Thailand | 1977 |
Antimalarial activity of S-isobutyl adenosine against Plasmodium falciparum in culture.
Topics: Adenosine; Chloroquine; Malaria; Plasmodium falciparum; Structure-Activity Relationship | 1978 |
[Connatal malaria (author's transl)].
Topics: Adult; Chloroquine; Female; Humans; Infant; Malaria; Maternal-Fetal Exchange; Plasmodium vivax; Preg | 1977 |
Malaria in a Honduras hunter.
Topics: Adult; Chloroquine; Honduras; Humans; Malaria; Male; Plasmodium vivax; Primaquine; Travel | 1978 |
Response of falciparum malaria to a standard regimen of chloroquine in Vientiane, Lao People's Democratic Republic.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Communicable Disease Control; Drug Evaluati | 1977 |
[Malaria prophylaxis].
Topics: Adult; Aged; Chloroquine; Drug Resistance; Female; Folic Acid Antagonists; Health Education; Humans; | 1978 |
[Clinical problems in current malaria. Considerations apropos of 2 cases].
Topics: Adult; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Seasons; Sicily; | 1978 |
Response of P. vivax and P. falciparum cases to presumptive treatment with chloroquine in some districts of Karnataka.
Topics: Adult; Child; Child, Preschool; Chloroquine; Humans; India; Malaria; Plasmodium falciparum; Plasmodi | 1977 |
The influence of acetylator phenotype on the response to sulfalene in individuals with chloroquine-resistant falciparum malaria.
Topics: Acetylation; Adult; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Mala | 1978 |
[Malaria; a summary].
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Plasmodium malariae; Plasmodiu | 1978 |
Falciparum malaria.
Topics: Australia; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; New Guinea; Plasmodium falcipar | 1978 |
The chemotherapy of rodent malaria, XXX. The enigmas of the 'NS lines' of P. berghei.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Malaria; Male; Mice; Plasmodium berghei | 1978 |
Relative chloroquine resistance of P falciparum in Zambia.
Topics: Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium falci | 1978 |
The chloroquine resistant chronic Vivax malaria presenting as malarial cachexia and secondary hypersplenism: (a case report).
Topics: Adolescent; Cachexia; Chloroquine; Chronic Disease; Drug Resistance, Microbial; Female; Humans; Hype | 1978 |
Malaria immunity and premunition in a Plasmodium berghei mouse model.
Topics: Animals; Chloroquine; Erythrocytes; Female; Humans; Immunization; Malaria; Mice; Mice, Inbred C3H; P | 1978 |
Plasmodial antigens exposed on the surface of infected reticulocytes: their role in induction of protective immunity in mice.
Topics: Animals; Antibodies; Antigens; Bone Marrow; Chloroquine; Immunization; Malaria; Mice; Mice, Inbred B | 1978 |
The spread of chloroquine-resistant falciparum malaria in Papua New Guinea.
Topics: Adult; Child; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; New Guinea; Plasmodium | 1978 |
Erythrocyte surface: novel determinant of drug susceptibility in rodent malaria.
Topics: Animals; Chloroquine; Cold Temperature; Drug Resistance, Microbial; Erythrocyte Membrane; Erythrocyt | 1978 |
[Malaria introduced into Switzerland from 1974-1976].
Topics: Adult; Chloroquine; Humans; Malaria; Neurologic Manifestations; Plasmodium falciparum; Plasmodium vi | 1978 |
Prevalence of chloroquine resistance in malaria.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; India; Malaria; Male; Middle Aged; Plasmodiu | 1978 |
The treatment of malaria.
Topics: Administration, Oral; Chloroquine; Humans; Injections, Intravenous; Malaria; Plasmodium falciparum | 1978 |
Response of Plasmodium falciparum in Sudan to oral chloroquine.
Topics: Administration, Oral; Animals; Blood; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plas | 1978 |
Species prevalence of malaria in northern and southern Sudan, and control by mass chemoprophylaxis.
Topics: Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Chloroquine; Humans; Infant; Malaria; Mid | 1978 |
Lack of chloroquine inhibition of erythrocytic glucose-6-phosphate dehydrogenase in malaria (Plasmodium berghei).
Topics: Animals; Chloroquine; Erythrocytes; Glucosephosphate Dehydrogenase; Malaria; Mice; Plasmodium berghe | 1978 |
Results of treatment of Plasmodium falciparum infection with chloroquine in some parts of Tamil Nadu.
Topics: Adult; Child; Chloroquine; Humans; India; Malaria; Plasmodium falciparum | 1978 |
Chloroquine-resistant falciparum malaria from Africa.
Topics: Adult; Africa; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparum; Recurrenc | 1979 |
Presumptive treatment of P. vivax and P. falciparum cases with 600 mg. chloroquine base in Tamil Nadu.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Humans; India; Infant; Malaria; Plasmodiu | 1978 |
A comparative study of malaria prophylaxis in peninsular Malaysia using chloroquine and a combination of sulphadoxine and pyrimethamine.
Topics: Adult; Child; Child, Preschool; Chloroquine; Drug Combinations; Female; Humans; Leukocyte Count; Mal | 1978 |
Chloroquine-resistant falciparum malaria.
Topics: Chloroquine; Drug Resistance; Humans; Malabsorption Syndromes; Malaria; Male; Middle Aged; Plasmodiu | 1978 |
The treatment of malaria.
Topics: Chloroquine; Drug Combinations; Female; Humans; Malaria; Plasmodium falciparum; Pyrimethamine | 1978 |
Chloroquine-resistant falciparum malaria.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1979 |
Chloroquine resistance in malaria: accessibility of drug receptors to mefloquine.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Malaria; Male; Mice; | 1979 |
[Course and intensive treatment of acute falciparum malaria (author's transl)].
Topics: Acute Disease; Adult; Chloroquine; Diagnosis, Differential; Dose-Response Relationship, Drug; Enceph | 1979 |
Occurrence of malaria acquired during travel abroad among American civilians, 1970-1976.
Topics: Adolescent; Adult; Africa; Asia; Central America; Child; Chloroquine; Female; Humans; Malaria; Male; | 1979 |
Falciparum malaria despite chemoprophylaxis.
Topics: Chloroquine; Dapsone; Drug Combinations; Humans; Malaria; Plasmodium falciparum; Pyrimethamine | 1979 |
Immunizations for travelers.
Topics: Adult; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Humans; Immunization; Infant; Mal | 1979 |
[Chloroquine-resistant tropical malaria following a trip to Kenya].
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Germany, West; Humans; Kenya; Malaria; Plasm | 1979 |
Falciparum malaria despite chemoprophylaxis.
Topics: Chloroquine; Female; Fetal Diseases; Humans; Malaria; Plasmodium falciparum; Pregnancy; Pregnancy Co | 1979 |
Results of 5-day course of radical treatment of Plasmodium vivax in six districts of Tamil Nadu.
Topics: Chloroquine; Female; Humans; India; Malaria; Male; Plasmodium vivax; Time Factors; World Health Orga | 1979 |
Chloroquine-resistant Plasmodium falciparum malaria in Kenya.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Kenya; Malaria; Male; Plasmodium falciparum; | 1979 |
Treatment of falciparum malaria in Thai children.
Topics: Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Drug Therapy, Combination; F | 1979 |
Drug-resistant falciparum malaria among the Mayongong Indians in the Brazilian Amazon.
Topics: Adolescent; Adult; Brazil; Child; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Female | 1979 |
[Production of interferon after infection by various doses of "Plasmodium berghei" in mice (author's transl)].
Topics: Animals; Chloroquine; Interferons; Malaria; Mice; Plasmodium berghei; Spleen; Splenectomy | 1979 |
Plasmodium berghei--infected mice. Focal glomerulonephritis in hyperimmune state.
Topics: Animals; Antibodies; Antibodies, Antinuclear; Antigens; Chloroquine; Complement C3; Glomerulonephrit | 1979 |
Malaria in Australia.
Topics: Australia; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; | 1979 |
Chloroquine-resistant falciparum malaria.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Middle Aged; Plasmodi | 1979 |
Experimental studies on the effect of proguanil and dapsone against chloroquine-resistant Plasmodium berghei (ANKA) in white mice.
Topics: Animals; Chloroquine; Dapsone; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Comb | 1979 |
Chloroquine-resistant falciparum malaria.
Topics: Australia; Chloroquine; Malaria; New Guinea; Plasmodium falciparum | 1979 |
Possible chloroquine-resistant Plasmodium falciparum in Nigeria.
Topics: Chloroquine; Drug Resistance; Drug Therapy, Combination; Erythrocytes; Humans; Malaria; Male; Middle | 1979 |
Chloroquine-resistant falciparum malaria in a Bangladeshi girl with acute lymphoblastic leukaemia.
Topics: Acute Disease; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Leukemia, Lymphoid; M | 1979 |
Chloroquine-resistant Plasmodium vivax malaria in infancy and childhood.
Topics: Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; Infant; Malaria; M | 1979 |
Imported parasitic infections in Tasmania.
Topics: Africa, Northern; Ancylostomiasis; Australia; Chloroquine; Helminthiasis; Humans; Intestinal Disease | 1979 |
Studies on the occurrence of a strain of chloroquine-resistant Plasmodium falciparum in Papua New Guinea.
Topics: Child; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; New Guinea; Plasmodium falciparum | 1978 |
Treatment and chemoprophylaxis of malaria.
Topics: Aminoquinolines; Antimalarials; Biguanides; Chloroquine; Dapsone; Humans; Malaria; Plasmodium falcip | 1979 |
The concentration of chloroquine in serum during short and long term malaria prophylaxis with standard and 'double' dosage in non-immunes: clinical implications.
Topics: Adult; Chloroquine; Drug Administration Schedule; Female; Humans; Malaria; Male; Plasmodium falcipar | 1979 |
Changes in serum lipoproteins during malariatherapy with Plasmodium vivax.
Topics: Adult; Chloroquine; Cholesterol; Humans; Lipoproteins; Malaria; Male; Plasmodium vivax; Thromboangii | 1979 |
[Imported malaria in a tropical unit in Paris. About 100 cases (author's transl)].
Topics: Africa; Asia; Chloroquine; Europe; Female; Humans; Malaria; Male; Paris; Plasmodium falciparum; Plas | 1979 |
Chemotherapy of falciparum malaria: regional differences in responsiveness to treatment.
Topics: Adult; Africa, Central; Africa, Western; Asia, Southeastern; Chloroquine; Drug Resistance; Drug Ther | 1979 |
Antimalarial activity of the optical isomers of chloroquine diphosphate.
Topics: Animals; Chloroquine; Lethal Dose 50; Malaria; Mice; Plasmodium berghei; Stereoisomerism | 1979 |
Chloroquine resistance in P. falciparum in Assam State.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; India; In | 1979 |
In vivo chloroquine sensitivity tests of Plasmodium falciparum in some parts of Uttar Pradesh and Haryana States.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; India; Infant; M | 1979 |
Response of Plasmodium falciparum to chloroquine in the Meghalaya State.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falciparum; World Health O | 1979 |
Results of chloroquine sensitivity tests in Plasmodium falciparum in Orissa State.
Topics: Adult; Animals; Chloroquine; Drug Resistance, Microbial; Humans; India; Malaria; Plasmodium falcipar | 1979 |
Response to chloroquine with and without pyrimethamine in Plasmodium falciparum in West Bengal, Tripura, Mizoram, Manipur and Arunachal Pradesh.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Pyrimethamine | 1979 |
Presumptive treatment of P. vivax malaria in Uttar Pradesh, Punjab, Haryana, Himachal Pradesh, Jammu and Kashmir.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Humans; India; Infant; Infant, Newborn; M | 1979 |
Presumptive treatment of P. vivax infection with 600 mg chloroquine base in the Malaria Eradication Programme in Madhya Pradesh.
Topics: Adult; Animals; Chloroquine; Humans; India; Malaria; Plasmodium vivax | 1979 |
[A rare cause of subdural effusion in children : cerebral malaria (author's transl)].
Topics: Child, Preschool; Chloroquine; Drainage; Female; Humans; Infant; Malaria; Male; Meningitis; Plasmodi | 1979 |
Activities of various 4-aminoquinolines against infections with chloroquine-resistant strains of Plasmodium falciparum.
Topics: Aminoquinolines; Amodiaquine; Animals; Chloroquine; Drug Resistance, Microbial; Female; Haplorhini; | 1977 |
Radical cure of infections with Plasmodium cynomolgi: a function of total 8-aminoquinoline dose.
Topics: Aminoquinolines; Animals; Antimalarials; Blood; Chloroquine; Female; Haplorhini; Macaca mulatta; Mal | 1977 |
The practical and therapeutic implications of chloroquine-induced itching in tropical Africa.
Topics: Adult; Child; Chloroquine; Female; Humans; Malaria; Male; Pruritus | 1977 |
Prophylaxis of malaria.
Topics: Antimalarials; Chloroquine; Female; Ghana; Humans; Malaria; Sulfadiazine | 1979 |
Extrapyramidal syndrome following chloroquine therapy.
Topics: Basal Ganglia Diseases; Child; Child, Preschool; Chloroquine; Female; Humans; Malaria; Male; Syndrom | 1979 |
Malaria--a red alert.
Topics: Aged; Child; Chloroquine; Drug Resistance; Drug Therapy, Combination; Health Education; Humans; Mala | 1979 |
Chemoprophylaxis of chloroquine-resistant malaria; an additional note.
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Pyrimethamine; Sulfadoxine | 1979 |
A pocket of controlled malaria in a holoendemic region of West Africa.
Topics: Amodiaquine; Anopheles; Child; Child, Preschool; Chloroquine; Costs and Cost Analysis; Humans; Liber | 1979 |
Habits of malaria chemoprophylaxis and an analysis of breakdowns in a West African mining town.
Topics: Chloroquine; Drug Administration Schedule; Drug Resistance; Humans; Liberia; Malaria; Plasmodium; Pr | 1979 |
Malaria--an American problem.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Humans; Malaria; Plasmodium; United States | 1979 |
[A case of chloroquine retinopathy during malaria prophylaxis in an adult].
Topics: Aged; Chloroquine; Humans; Malaria; Male; Retinal Diseases | 1979 |
Prolonged malaria prophylaxis.
Topics: Chloroquine; Humans; Malaria; Retinal Diseases; Time Factors | 1977 |
Prolonged malaria prophylaxis.
Topics: Aerospace Medicine; Chloroquine; Humans; Malaria | 1977 |
Chemoprophylaxis of malaria.
Topics: Chloroquine; Drug Evaluation; Drug Resistance, Microbial; Malaria; Proguanil; Pyrimethamine | 1977 |
Prolonged malaria prophylaxis.
Topics: Chloroquine; Humans; Malaria; Retinal Diseases | 1978 |
Prolonged malaria prophylaxis.
Topics: Chloroquine; Humans; Malaria; Time Factors | 1978 |
Current concepts in malaria.
Topics: Chloroquine; Humans; Malaria; Male; United States | 1978 |
[Malaria: 4 case reports with "atypical" symptoms (author's transl)].
Topics: Adult; Chloroquine; Drug Resistance; Enteritis; Female; Humans; Lung; Malaria; Male; Middle Aged; Pr | 1978 |
Prophylaxis of malaria.
Topics: Chloroquine; Humans; Malaria | 1978 |
The treatment of malaria.
Topics: Chloroquine; Drug Administration Schedule; Humans; Malaria | 1978 |
[Peculiarities in 30 cases of malaria at the Medical Hospital in Freiburg].
Topics: Aged; Alcoholism; Chloroquine; Female; Germany, West; Humans; Malaria; Male; Middle Aged; Travel | 1978 |
[Perinatal transmission of Plasmodium falciparum malaria].
Topics: Adult; Anemia, Hemolytic; Blood Transfusion; Chloroquine; Female; Glucosephosphate Dehydrogenase; Hu | 1975 |
Chloroquine sensitivity of Plasmodium falciparum in Ethiopia. I. Results of an in vivo test.
Topics: Chloroquine; Drug Resistance, Microbial; Ethiopia; Malaria; Microbial Sensitivity Tests; Plasmodium | 1976 |
Response of P. falciparum infection to chloroquine therapy in some parts of Tamil Nadu and Karnataka States.
Topics: Adult; Child; Chloroquine; Humans; India; Malaria; Plasmodium falciparum | 1975 |
Treatment of P. falciparum with chloroquine and primaquine in Dharmapuri District, Tamil Nadu.
Topics: Adult; Child; Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium falciparum; | 1975 |
Chloroquine-resistant falciparum malaria in East Kalimantan, Indonesia.
Topics: Adolescent; Adult; Borneo; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Ma | 1976 |
Chloroquine-resistant falciparum malaria from Irian Jaya (Indonesian New Guinea).
Topics: Amodiaquine; Chloroquine; Drug Resistance; Humans; Malaria; Male; Piperidines; Plasmodium falciparum | 1976 |
[Malaria prophylaxis].
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Netherlands; Plasmodium; Plasmodium falcip | 1976 |
Increased frequency of chloroquine resistant P. falciparum on a rubber estate in Peninsular Malaysia during two years of systematic chloroquine treatment.
Topics: Blood; Chloroquine; Drug Resistance, Microbial; Humans; Longitudinal Studies; Malaria; Malaysia; Pla | 1975 |
Plasmodium berghei: phase contrast and electron microscopical evidence that certain antimalarials can both inhibit and reverse pigment clumping caused by chloroquine.
Topics: Animals; Antimalarials; Chloroquine; Cytoplasmic Granules; Erythrocytes; Female; Malaria; Mice; Phen | 1976 |
Malaria - the mime. Recent lessons from a group of civilian travellers.
Topics: Adolescent; Adult; Aged; Child; Chloroquine; Diagnosis, Differential; Economics, Medical; Female; Hu | 1976 |
Symptoms and signs of malaria.
Topics: Adult; Canada; Child; Chloroquine; Female; Humans; Infant; Malaria; Male; Plasmodium falciparum | 1976 |
The chemotherapy of rodent malaria, XXIV. The blood schizontocidal action of erythromycin upon Plasmodium berghei.
Topics: Animals; Chloroquine; Drug Resistance; Drug Synergism; Erythrocytes; Erythromycin; Malaria; Male; Mi | 1976 |
The chemotherapy of rodent malaria, XXV. Antimalarial activity of WR 122,455 (a 9-phenanthrenemethanol) in vivo and in vitro.
Topics: Administration, Oral; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug To | 1976 |
The chemotherapy of rodent malaria, XXVI. The potential value of WR 122,455 (a 9-phenanthrenemethanol) against drug-resistant malaria parasites.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Malaria; Male; Mice; Phenanthren | 1976 |
Chemoprophylaxis of malaria.
Topics: Adult; Antimalarials; Chloroquine; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; | 1976 |
Preliminary studies on the response of Plasmodium falciparum to chloroquine in the Philippines, with the in vitro technique.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Methods; Philippines; Plasmodium falciparu | 1976 |
Chloroquine-resistant falciparum malaria in Papua New Guinea.
Topics: Adolescent; Chloroquine; Female; Humans; Malaria; New Guinea; Plasmodium falciparum | 1976 |
Infectivity of falciparum malaria patients for anopheline mosquitoes before and after chloroquine treatment.
Topics: Adolescent; Adult; Animals; Anopheles; Child; Chloroquine; Feeding Behavior; Female; Humans; Malaria | 1976 |
Treatment of P. falciparum infection with chloroquine and primaquine in Salem and Sathyamangalam towns of Tamil Nadu.
Topics: Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium falciparum; Primaquine | 1976 |
A comparative study of the efficacy of chloroquine and a combination of dapsone and pyrimethamine in the prophylaxis of malaria in Peninsular Malaysia.
Topics: Adult; Child; Chloroquine; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; M | 1976 |
Chloroquine-resistant falciparum malaria acquired in Papua New Guinea.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; New Guinea; Plasmodium falcip | 1976 |
Additional foci of chloroquine-resistant falciparum malaria in East Kalimantan and West Irian, Indonesia.
Topics: Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Indonesia; Iran; Malaria | 1976 |
[Chemotherapy of acute malaria attacks in patients returning from tropical and subtropical countries (author's transl)].
Topics: Antimalarials; Chloroquine; Diagnosis, Differential; Drug Resistance, Microbial; Germany, West; Huma | 1976 |
Chloroquine resistance trials in Papua New Guinea. 1. Maprik and Popondetta areas.
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malari | 1976 |
Chemotherapy of Plasmodium vivax in Saimiri and Aotus models.
Topics: Administration, Oral; Animals; Chloroquine; Disease Models, Animal; Drug Combinations; Drug Evaluati | 1975 |
Antiplasmodial efficacy of 2,4--diaminopyrimidine0sylfonamide combinations, especially against chloroquine-resistant malaria.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Evaluation, Preclinical; Drug Resistance, Microb | 1975 |
[Letter: Prevention of malaria with chloroquine].
Topics: Chloroquine; Humans; Malaria | 1975 |
Malaria in studies in vitro. III: the protein synthesising activity of Plasmodium falciparum in vitro after drug treatment in vivo.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Female; Haplorhini; Leucine; Mal | 1975 |
Protein synthesis in vitro by cryopreserved Plasmodium falciparum.
Topics: Animals; Carbon Radioisotopes; Chloroquine; Erythrocytes; Freezing; Haplorhini; Humans; Isoleucine; | 1975 |
Malarial infections in Aotus trivirgatus with special reference to renal pathology. II. P. falciparum and mixed malaria infections.
Topics: Animals; Aotus trivirgatus; Biopsy; Chloroquine; Glomerulonephritis; Haplorhini; Kidney; Kidney Dise | 1975 |
Plasmodium knowlesi: morphology and course of infection in rhesus monkeys treated with clindamycin and its N-demethyl-4'-pentyl analog.
Topics: Animals; Blood; Chloroquine; Clindamycin; Endoplasmic Reticulum; Erythrocytes; Haplorhini; Macaca mu | 1976 |
[Recommendations for travel and residence in the tropics (author's transl)].
Topics: Activities of Daily Living; Adult; Alcohol Drinking; Child; Chloroquine; Diet; Female; Humans; Hygie | 1976 |
[Chemotherapy and chemoprophylaxis of malaria (author's transl)].
Topics: Adult; Amodiaquine; Antimalarials; Asia, Southeastern; Central America; Child; Chloroquine; Drug Res | 1976 |
[Serodiagnosis of malaria (author's transl)].
Topics: Adult; Antibodies; Chad; Chloroquine; Female; Fluorescent Antibody Technique; Germany, West; Ghana; | 1976 |
Chloroquine induced involuntary movements.
Topics: Adolescent; Adult; Child; Chloroquine; Female; Humans; Malaria; Male; Movement Disorders | 1977 |
[Prevention and therapy of malaria and amebiasis].
Topics: Acetamides; Amebiasis; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Emetine; Humans; | 1977 |
Plasmodium ovale malaria in Canada following transfusion.
Topics: Antibodies; Canada; Chloroquine; Female; Humans; Malaria; Middle Aged; Primaquine; Transfusion React | 1977 |
[Present-day problems of malaria. Prophylaxis and treatment].
Topics: Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Pregnancy; Quinine | 1977 |
Letter: Chloroquine in malaria chemotherapy.
Topics: Chloroquine; Humans; Malaria | 1976 |
An unusual reaction to chloroquine-primaquine.
Topics: Adult; Chloroquine; Coproporphyrins; Female; Humans; Malaria; Porphyrias; Primaquine; Uroporphyrins | 1976 |
[Chemoprophylaxis of malaria].
Topics: Africa; Asia; Chloroquine; Humans; Hungary; Malaria; Proguanil; Pyrimethamine; South America | 1976 |
Letter: Malaria prophylaxis.
Topics: Chloroquine; Humans; Malaria; Tropical Medicine | 1976 |
[Clinical and epidemiological characteristics of malaria in the City Kiev in 1967-1974].
Topics: Adult; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Quinolines; Ukraine | 1976 |
Malaria complicating neoplastic disease.
Topics: Adult; Antibodies; Antibody Formation; Chloroquine; Colonic Neoplasms; Female; Hemostasis, Surgical; | 1976 |
Chloroquine resistant malaria in Papua New Guinea.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; New Guinea | 1976 |
Letter: Unexplained fever.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; P | 1975 |
Rodent systems (Plasmodium berghei-Anopheles Stephensi) for screening compounds for potential causal prophylaxis.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Female; Malaria; Mice; | 1975 |
Letter: Prevention of chloroquine-resistant falciparum malaria.
Topics: Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Malaria; Plasmo | 1975 |
Chloroquine-resistant falciparum malaria from West Irian and East Kalimantan.
Topics: Adult; Asia, Southeastern; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparu | 1975 |
Falciparum malaria semi-resistant to clindamycin.
Topics: Blood; Child; Chloroquine; Clindamycin; Colitis; Digestive System; Drug Resistance; Drug Therapy, Co | 1975 |
Sulfadoxine and pyrimethamine in the treatment of falciparum malaria in Vietnam.
Topics: Adolescent; Adult; Blood; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance, | 1975 |
Chloroquine resistant malaria in West Malaysia.
Topics: Anopheles; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malaysia; Plasmodium falciparum | 1975 |
The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Diamines; Drug Evaluation, Preclinical; | 1975 |
Chloroquine resistance of Plasmodium falciparum in West Irian and East Kalimantan.
Topics: Adult; Chloroquine; Drug Resistance; Erythrocytes; Humans; Indonesia; Malaria; Male; Plasmodium falc | 1975 |
Thiosemicarbazones and hydrazones of alpha-methylchalkone as potential chemotherapeutic agents.
Topics: Animals; Antimalarials; Antineoplastic Agents; Carcinoma 256, Walker; Chalcone; Chloroquine; Drug Ev | 1975 |
[Malaria tropica--diagnosis and diagnostic errors].
Topics: Adult; Aged; Chloroquine; Diagnostic Errors; Female; Humans; Malaria; Male; Plasmodium falciparum; P | 1975 |
[Malaria in children, with special reference to cerebral malaria (author's transl)].
Topics: Age Factors; Anemia, Hemolytic; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; Chloroquine | 1975 |
Probable chloroquine-resistant Plasmodium falciparum malaria from Mozambique A case report.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Mozambique; Plasmodium falc | 1975 |
Some effects of partial malaria suppression in Ugandan children during the first 3 years of life.
Topics: Antibodies; Child, Preschool; Chloroquine; Humans; Infant; Malaria; Plasmodium falciparum; Pyrimetha | 1975 |
Longitudinal malaria studies in rural Northeast Thailand. Chloroquine treatment of falciparum malaria infections.
Topics: Adult; Child; Child, Preschool; Chloroquine; Drug Evaluation; Drug Resistance, Microbial; Female; Hu | 1975 |
Acetylator phenotype and response of individuals infected with a chloroquine-resistant strain of Plasmodium falciparum to sulfalene and pyrimethamine.
Topics: Acetylation; Adult; Chloroquine; Drug Administration Schedule; Drug Resistance, Microbial; Drug Ther | 1975 |
Chloroquine resistance in malaria: variations of substrate-stimulated chloroquine accumulation.
Topics: Animals; Blood Glucose; Chloroquine; Drug Resistance; Erythrocytes; Malaria; Male; Mice; Mice, Inbre | 1975 |
The treatment of malaria.
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Plasmodium malariae; Plasmodiu | 1975 |
Chloroquine in malaria chemotherapy.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1975 |
Evaluation of in vitro drug sensitivity of human Plasmodium falciparum by incorporation of radioactive isoleucine.
Topics: Carbon Radioisotopes; Chloroquine; Humans; Isoleucine; Malaria; Microbial Sensitivity Tests; Plasmod | 1975 |
[Tropical malaria infections. Diagnostic and therapeutic problems].
Topics: Adult; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum | 1976 |
Congenital atrial flutter.
Topics: Atrial Flutter; Chloramphenicol; Chloroquine; Digoxin; Electrocardiography; Female; Fetal Diseases; | 1975 |
Studies on the metabolism of chloroquine in rhesus monkeys and human subjects.
Topics: Animals; Chloroquine; Chromatography, Gas; Diuresis; Humans; Kidney; Liver; Macaca mulatta; Malaria; | 1975 |
Spectrofluorometric and spectrodensitometric determination of chloroquine in plasma and urine.
Topics: Chloroquine; Densitometry; Humans; Kidney Diseases; Malaria; Spectrometry, Fluorescence | 1975 |
Letter: Accelerated hemostasis in chloroquine-treated rats.
Topics: Animals; Blood Coagulation; Chloroquine; Female; Malaria; Male; Rats | 1975 |
[Eye complications in the long-term treatment with chloroquin. Study carried out in Togo].
Topics: Cataract; Chloroquine; Corneal Opacity; Eye Diseases; Female; Humans; Macular Degeneration; Malaria; | 1975 |
Evidence for a relationship between chloroquine and complement from studies with lymphocyte mitogens: possible implications for the mechanism of action of chloroquine in disease.
Topics: Animals; Autoimmune Diseases; Cells, Cultured; Chloroquine; Complement System Proteins; Concanavalin | 1975 |
Letter: Malarial prophylaxis for pregnant women.
Topics: Chloroquine; Female; Fetus; Humans; Malaria; Pregnancy; Pregnancy Complications, Infectious | 1976 |
Haematological problems in immigrants.
Topics: Adolescent; Adult; Anemia, Hypochromic; Anemia, Megaloblastic; Anemia, Sickle Cell; Child; Chloroqui | 1976 |
Malaria--general management as recommended by WHO.
Topics: Adult; Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Cerebral; Malar | 1992 |
"Antimalarial" medicinal plants and their impact on cell populations in various organs of mice.
Topics: Animals; Bone Marrow; Chloroquine; Drug Evaluation, Preclinical; Erythrocyte Count; Hematocrit; Live | 1992 |
Status of oxidative stress and antioxidant defences during Plasmodium knowlesi infection and chloroquine treatment in Macaca mulatta.
Topics: Animals; Chloroquine; Macaca mulatta; Malaria; Oxidation-Reduction; Plasmodium knowlesi; Superoxides | 1992 |
[Current health information for Spanish travellers to tropical areas].
Topics: Centers for Disease Control and Prevention, U.S.; Chloroquine; Health Education; Humans; Information | 1992 |
Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase.
Topics: Animals; Antimalarials; Chloroquine; Dihydroorotase; Dihydroorotate Dehydrogenase; Kinetics; Macroph | 1992 |
Knowledge and beliefs about malaria on the Pacific coastal plain of Guatemala.
Topics: Adult; Analysis of Variance; Animals; Chloroquine; Culicidae; Educational Status; Female; Guatemala; | 1992 |
Sequential concentration of chloroquine in human hair correlates with ingested dose and duration of therapy.
Topics: Adult; Aged; Chloroquine; Chromatography, Gas; Drug Overdose; Female; Hair; Humans; Lupus Erythemato | 1992 |
Occurrence of chloroquine-induced psychotic manifestations in children with malaria.
Topics: Child; Chloroquine; Female; Hallucinations; Humans; Malaria; Male; Psychoses, Substance-Induced | 1992 |
[Malaria prevention].
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Doxycycline; Drug Therapy, Combination; Humans | 1992 |
[Short term cultivation of Plasmodium for the determination of chloroquine resistance].
Topics: Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium | 1992 |
Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.
Topics: Animals; Arginine; Chloroquine; Deferoxamine; Female; Immunization; Interferon-gamma; Liver; Malaria | 1992 |
Drug interaction of chloroquine with ciclosporin.
Topics: Chloroquine; Cyclosporine; Drug Interactions; Humans; Kidney Failure, Chronic; Malaria; Male; Middle | 1992 |
Imported malaria in the Bronx: review of 51 cases recorded from 1986 to 1991.
Topics: Adolescent; Adult; Africa, Western; Animals; Antimalarials; Asia, Western; Chi-Square Distribution; | 1992 |
Heme polymerase: modulation by chloroquine treatment of a rodent malaria.
Topics: Animals; Chloroquine; Enzyme Stability; Erythrocytes; Hemin; Hot Temperature; Hydrogen-Ion Concentra | 1992 |
Antibody response in Plasmodium vinckei malaria after treatment with chloroquine and adjuvant interferon-gamma.
Topics: Animals; Antibodies, Protozoan; Chemotherapy, Adjuvant; Chloroquine; Female; Fluorescent Antibody Te | 1992 |
Severity of imported malaria.
Topics: Chloroquine; Humans; Malaria | 1992 |
[Malaria. Epidemiology, etiology, physiopathology, diagnosis, development, prognosis, treatment, prevention].
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium; Prognosis | 1992 |
Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy.
Topics: Animals; Chloroquine; Hexokinase; Macaca mulatta; Malaria; Phosphofructokinase-1; Plasmodium knowles | 1992 |
Psoriasis worsened by antimalarial prophylaxis.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Male; Middle Aged; Psoriasis | 1992 |
Susceptibility of Macaca fascicularis monkeys from Mauritius to different species of Plasmodium.
Topics: Animals; Chloroquine; Disease Susceptibility; Drug Therapy, Combination; Macaca fascicularis; Malari | 1992 |
Persisting chloroquine-induced myasthenia?
Topics: Chloroquine; Edrophonium; Female; Humans; Malaria; Middle Aged; Muscles; Myasthenia Gravis | 1991 |
Resistance to chloroquine by Plasmodium vivax in Irian Jaya, Indonesia.
Topics: Animals; Chloroquine; Culicidae; Drug Resistance; Humans; Indonesia; Insect Vectors; Malaria; Plasmo | 1991 |
Correlation between in vivo and in vitro response of chloroquine-resistant Plasmodium falciparum in Calabar, south-eastern Nigeria.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria; Nigeria; Pl | 1991 |
Efficacy of amodiaquine against chloroquine-resistant malaria in Cameroon.
Topics: Adolescent; Adult; Amodiaquine; Animals; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resist | 1991 |
Malaria vaccines in the future--what strategies now?
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Forecasting; Humans; Malaria; Mosquito Control | 1991 |
Plasmodium chabaudi: association of reversal of chloroquine resistance with increased accumulation of chloroquine in resistant parasites.
Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Ch | 1992 |
Ultrastructural changes associated with reversal of chloroquine resistance by verapamil in Plasmodium chabaudi.
Topics: Animals; Chloroquine; Cytoplasm; Drug Interactions; Drug Resistance; Endoplasmic Reticulum; Female; | 1991 |
[Malaria chemoprophylaxis].
Topics: Asia; Chloroquine; Denmark; Doxycycline; Humans; Malaria; Proguanil; Travel | 1991 |
In vitro sensitivity of southern African reference isolates of Plasmodium falciparum to chloroquine and pyrimethamine.
Topics: Africa, Southern; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Microbial Sensitivity Test | 1991 |
[Development of chloroquine resistance in an urban area. Results of surveys in Dakar and Pikine].
Topics: Animals; Chloroquine; Humans; Malaria; Plasmodium; Senegal; Urban Population | 1991 |
Malaria prophylaxis.
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Trav | 1991 |
Drug use and design in the nineties.
Topics: Aminoquinolines; Amodiaquine; Antimalarials; Artemisinins; Calcium Channel Blockers; Chloroquine; Hu | 1991 |
Chloroquine-induced pruritus: its impact on chloroquine utilization in malaria control in Dar es Salaam.
Topics: Chloroquine; Drug Eruptions; Humans; Malaria; Pruritus; Surveys and Questionnaires; Tanzania | 1991 |
[Prophylaxis of malaria].
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Mefloquine | 1991 |
Kinetic modelling of chloroquine uptake by malaria-infected erythrocytes. Assessment of the factors that may determine drug resistance.
Topics: Animals; Chloroquine; Drug Resistance; Erythrocytes; Malaria; Mathematics; Models, Biological; Plasm | 1991 |
[Apropos of the prophylaxis of malaria].
Topics: Antimalarials; Chloroquine; Humans; Malaria; Proguanil | 1991 |
[Prevention and treatment of malaria in expatriates living in Black Africa. Influence of chemoresistance. Investigations conducted in Brazzaville (Congo)].
Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; | 1991 |
Interactions of chloroquine with benzodiazepine, gamma-aminobutyric acid and opiate receptors.
Topics: Animals; Benzodiazepines; Binding, Competitive; Chloroquine; Drug Interactions; GABA-A Receptor Anta | 1991 |
Human malaria infectiousness measured by age-specific sporozoite rates in Anopheles gambiae in Tanzania.
Topics: Age Factors; Animals; Anopheles; Chloroquine; Female; Humans; Insect Vectors; Least-Squares Analysis | 1991 |
[The prophylaxis of malaria].
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1991 |
Stabilization of drug resistance (chloroquine and amodiaquine) of Plasmodium falciparum in semiimmune populations in the Congo.
Topics: Amodiaquine; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1991 |
Malaria in travelers in Rhode Island: a review of 26 cases.
Topics: Adolescent; Adult; Africa; Animals; Antimalarials; Chloroquine; Diagnosis, Differential; Emigration | 1991 |
Resistance to antimalarials by Plasmodium falciparum in Arso PIR, Irian Jaya, Indonesia.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans | 1991 |
Infection of Aotus vociferans monkeys with different strains of Plasmodium falciparum.
Topics: Amodiaquine; Animals; Anopheles; Cebidae; Chloroquine; Malaria; Mefloquine; Plasmodium falciparum; T | 1991 |
A case of chloroquine resistant Falciparum malaria in Saudi Arabia.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Sa | 1991 |
Standard and reduced doses of mefloquine for treatment of Plasmodium falciparum in Tanzania: whole blood concentrations in relation to adverse reactions, in vivo response, and in vitro susceptibility.
Topics: Adolescent; Animals; Child; Chloroquine; Drug Administration Schedule; Humans; Malaria; Mefloquine; | 1991 |
Chronotherapy of malaria: identification of drug-sensitive stage of parasite and timing of drug delivery for improved therapy.
Topics: Animals; Chloroquine; Disease Models, Animal; Injections, Subcutaneous; Malaria; Male; Mice; Periodi | 1991 |
Status of hepatic heme and heme oxygenase during Plasmodium yoelii nigeriensis infection in mice.
Topics: Administration, Oral; Animals; Cell Fractionation; Chloroquine; Cobalt; Heme; Heme Oxygenase (Decycl | 1991 |
Chloroquine-induced mania.
Topics: Adult; Bipolar Disorder; Chloroquine; Humans; Malaria; Male | 1991 |
Interferon-gamma enhances the effect of antimalarial chemotherapy in murine Plasmodium vinckei malaria.
Topics: Animals; Chloroquine; Combined Modality Therapy; Female; Interferon-gamma; Malaria; Mice; Mice, Inbr | 1991 |
[Malaria of importation in the child: epidemiological, clinical and therapeutic analysis. Apropos of 70 cases observed in a pediatric hospital in Paris].
Topics: Africa; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria; Malaria, Fal | 1991 |
[Subacute chloroquine overdosage].
Topics: Accommodation, Ocular; Acute Disease; Adult; Chloroquine; Drug Overdose; Hair Color; Heliotherapy; H | 1991 |
Effect of Plasmodium berghei infection and chloroquine on the hepatic drug metabolizing system of mice.
Topics: Animals; Chloroquine; Cytochrome P-450 Enzyme System; Isoenzymes; Malaria; Mice; Microsomes, Liver; | 1991 |
Ability of Anopheles gambiae mosquitoes to transmit malaria during the dry and wet seasons in an area of irrigated rice cultivation in The Gambia.
Topics: Age Factors; Animals; Anopheles; Child; Child, Preschool; Chloroquine; Cohort Studies; Gambia; Human | 1991 |
[Current aspects of malarial chemoresistance of subjects autochthonous in the OCCGE countries (West Africa)].
Topics: Africa, Western; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparu | 1991 |
Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine.
Topics: Adult; Aged; Amodiaquine; Antibodies, Anti-Idiotypic; Chloroquine; Dose-Response Relationship, Immun | 1991 |
Diagnosis of malaria during chloroquine/proguanil prophylaxis.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Drug Combinations; Female; Humans; Malaria; | 1990 |
Proguanil, chloroquine, and mouth ulcers.
Topics: Animals; Chloroquine; Humans; Malaria; Military Personnel; Mouth Diseases; Plasmodium falciparum; Pr | 1990 |
Plasma levels of tumor necrosis factor during a longitudinal survey in an endemic area of malaria.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Female; Humans; Longitudinal Studies; Malar | 1990 |
Reversal of chloroquine-resistant falciparum malaria.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1990 |
Malaria and its treatment in rural villages of Aboh Mbaise, Imo State, Nigeria.
Topics: Age Factors; Animals; Body Temperature; Child, Preschool; Chloroquine; Female; Humans; Infant; Malar | 1990 |
Imported Plasmodium falciparum malaria in American travelers to Africa. Implications for prevention strategies.
Topics: Africa, Eastern; Africa, Western; Animals; Chloroquine; Drug Resistance; Malaria; Mefloquine; Plasmo | 1991 |
Prevention of malaria.
Topics: Africa; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Travel | 1991 |
Severe falciparum malaria in nonendemic areas: an unrecognized medical emergency.
Topics: Adult; Aged; Animals; Canada; Child, Preschool; Chloroquine; Communicable Disease Control; Emergenci | 1991 |
Clinical diagnosis of malaria: can we improve?
Topics: Chloroquine; Humans; Malaria; Medical History Taking; Parasitology; Predictive Value of Tests; Sensi | 1991 |
[Compliance in malaria prophylaxis with chloroquine and proguanil].
Topics: Adult; Chloroquine; Humans; Malaria; Patient Compliance; Proguanil; Tablets; Travel | 1991 |
Chloroquine-resistant Plasmodium vivax from Indonesia.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Indonesia; Malaria; Male; Plasmodium vivax | 1991 |
Clinical and laboratory features of severe and complicated falciparum malaria the experience from Gonder Hospital.
Topics: Adolescent; Adult; Aged; Animals; Chloroquine; Ethiopia; Female; Humans; Malaria; Male; Middle Aged; | 1991 |
Canadian recommendations for the prevention and treatment of malaria among international travellers.
Topics: Antimalarials; Chloroquine; Global Health; Humans; Malaria; Mosquito Control; Risk Factors; Travel | 1991 |
Endoscopic assessment of chloroquine phosphate-induced damage to esophageal, gastric, and duodenal mucosa.
Topics: Adult; Antimalarials; Chloroquine; Endoscopy, Digestive System; Esophagus; Female; Gastric Mucosa; G | 1991 |
Pefloxacin for falciparum malaria: only modest success.
Topics: Adolescent; Adult; Animals; Chloroquine; Drug Administration Schedule; Drug Resistance; Female; Huma | 1991 |
Chloroquine-resistant Plasmodium falciparum with reduced sensitivity in vitro to mefloquine and quinine in Zaria, northern Nigeria.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria; Mefloquine; | 1991 |
Childhood cerebral malaria in Ibadan.
Topics: Acute Disease; Child; Child, Preschool; Chloroquine; Coma; Female; Humans; Infant; Malaria; Male; Ni | 1991 |
Pregnancy outcome following first trimester exposure to chloroquine.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adolescent; Adult; Arthritis, Rheumatoid; Chloro | 1991 |
[Exacerbation of psoriasis caused by malaria prophylaxis with chloroquine and proguanil].
Topics: Chloroquine; Humans; Malaria; Male; Middle Aged; Proguanil; Psoriasis | 1991 |
Pyrimethamine-sulfadoxine (Fansidar) resistance in a non-immune Kenyan--a case report.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Humans; Kenya; Malar | 1991 |
Malaria in Israel: the Ethiopian connection.
Topics: Adolescent; Adult; Animals; Anopheles; Child; Child, Preschool; Chloroquine; Drug Resistance; Ethiop | 1991 |
Acute gluteal abscess following intramuscular chloroquine injection: a clinical and experimental study.
Topics: Abscess; Adolescent; Adult; Animals; Buttocks; Chlorocebus aethiops; Chloroquine; Female; Humans; In | 1991 |
[An unusual case of imported malaria].
Topics: Animals; Chloroquine; Female; Humans; Malaria; Middle Aged; Plasmodium; Primaquine; Serologic Tests; | 1991 |
Widespread in vitro resistance to chloroquine of Plasmodium falciparum in the Congo, 1987.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Congo; Drug Resistance; Humans; Infant; M | 1991 |
Chloroquine resistance in Plasmodium vivax.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium vivax; Recurrence | 1991 |
Medical treatment of malaria.
Topics: Adult; Chloroquine; Humans; Malaria; Male; Middle Aged | 1991 |
Problems of chloroquine-resistant P. falciparum in Nigeria: one antimalaria drugs' utilisation in metropolitan Calabar.
Topics: Adult; Animals; Chloroquine; Drug Resistance, Microbial; Educational Status; Female; Humans; Malaria | 1991 |
In vivo chloroquine resistant P. falciparum in Calcutta. A case report.
Topics: Animals; Chloroquine; Developing Countries; Drug Resistance; Humans; Malaria; Male; Middle Aged; Pla | 1991 |
[Comparative efficacy of chloroquine and amodiaquine (25 and 35 mg/kg) in school children infected with P. falciparum (Brazzaville, March 1990)].
Topics: Amodiaquine; Animals; Child; Chloroquine; Congo; Humans; Malaria; Plasmodium falciparum | 1991 |
[Chemoprophylaxis of Plasmodium falciparum malaria by a combination of 100 mg of chloroquine and 200 mg of proguanil per day in a zone III of chloroquine resistance (Gabon). Study of 431 French soldiers].
Topics: Animals; Chloroquine; Drug Resistance; Drug Therapy, Combination; France; Gabon; Humans; Malaria; Mi | 1991 |
Application of a simplified in-vivo test system for determining chloroquine resistance in Plasmodium falciparum.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Dose-Response Relationship, Drug; Dru | 1990 |
Malaria in Vietnam.
Topics: Chloroquine; Humans; Malaria; Vietnam | 1990 |
[Aspects of in vivo chemosensitivity of Plasmodium falciparum to chloroquine in a village of the Highland Plateaux of Madagascar in 1989].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Madagascar; Malaria; Male; Plasmodium | 1990 |
Activities of new acridone alkaloid derivatives against Plasmodium yoelii in vitro.
Topics: Acridines; Acridones; Alkaloids; Animals; Antimalarials; Cell Survival; Chloroquine; Erythrocytes; I | 1990 |
Identification of a chloroquine artifact by gas chromatography-mass spectrometry.
Topics: Acetic Anhydrides; Animals; Chloroquine; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Human | 1990 |
[A case of chloroquine-resistant malaria in Senegal].
Topics: Animals; Chloroquine; Drug Resistance; France; Humans; Malaria; Male; Middle Aged; Plasmodium falcip | 1990 |
[Imported malaria in Bordeaux in 1989. Epidemiologic, clinical and therapeutic study of 71 cases].
Topics: Animals; Antimalarials; Chloroquine; Female; France; Humans; Malaria; Male; Mefloquine; Phenanthrene | 1990 |
Complications of seasonal adult malaria at a central hospital.
Topics: Adolescent; Adult; Aged; Animals; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Hospita | 1990 |
In vivo test for sensitivity of Plasmodium falciparum to chloroquine in Faridabad complex of Haryana (India).
Topics: Adolescent; Adult; Animals; Child; Chloroquine; Drug Resistance; Female; Humans; India; Malaria; Mal | 1990 |
Plasmodium falciparum--chloroquine in vivo test in northeast India: reclassification and extended follow-up till day 14.
Topics: Animals; Chloroquine; Female; Humans; India; Malaria; Male; Plasmodium falciparum | 1990 |
[Imported fever in a 4-year-old boy].
Topics: Africa, Central; Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resi | 1990 |
Malaria survey in some parts of Namsang Circle of Tirap District, Arunachal Pradesh.
Topics: Adolescent; Adult; Animals; Anopheles; Child; Child, Preschool; Chloroquine; Drug Resistance; Female | 1990 |
Pattern of relapses in sporozoite induced Plasmodium cynomolgi B infection in rhesus monkeys.
Topics: Animals; Chloroquine; Disease Models, Animal; Macaca mulatta; Malaria; Recurrence; Time Factors | 1990 |
An in-vitro profile of the action of four antimalarials on indigenous cases of Plasmodium falciparum malaria in Karnataka.
Topics: Amodiaquine; Animals; Chloroquine; Drug Resistance, Microbial; Malaria; Mefloquine; Microbial Sensit | 1990 |
Chloroquine-resistant Plasmodium falciparum malaria at Nchelenge, northeastern Zambia. Follow-up on 515 hospital patients.
Topics: Adolescent; Age Factors; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Fol | 1990 |
[The treatment of imported Plasmodium falciparum malaria with halofantrine. Apropos of 59 case reports (corrected and republished article orginally printed in Med Trop (Mars) 1990 Jan-Mar;50(1):113-7)].
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria; Ma | 1990 |
Effects of interferon in malaria infection.
Topics: Animals; Antiviral Agents; Chloroquine; Female; Interferon Type I; Interferon-gamma; Macaca mulatta; | 1990 |
Experimental studies on combinations of pyronaridine/primaquine versus chloroquine/primaquine.
Topics: Animals; Antimalarials; Chloroquine; Drug Therapy, Combination; Macaca mulatta; Malaria; Mice; Napht | 1990 |
[A case of Plasmodium falciparum malaria contracted in Guinea-Bissau during chemoprophylaxis with chloroquine].
Topics: Animals; Chloroquine; Drug Resistance; Female; Humans; Malaria; Mefloquine; Middle Aged; Plasmodium | 1990 |
Recommendations for the prevention of malaria among travelers.
Topics: Adult; Animals; Antimalarials; Breast Feeding; Centers for Disease Control and Prevention, U.S.; Chi | 1990 |
[Uncommon clinical aspects of Plasmodium falciparum malaria].
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Hu | 1990 |
[In-vivo evaluation of Plasmodium falciparum sensitivity to chloroquine in Abidjan].
Topics: Animals; Child; Child, Preschool; Chloroquine; Cote d'Ivoire; Female; Humans; Malaria; Male; Microbi | 1990 |
[Prophylaxis of malaria. Current need for awareness of risk].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1990 |
Malaria in children.
Topics: Adolescent; Anemia; Animals; Child; Chloroquine; Diagnosis, Differential; Emergencies; Female; Fever | 1990 |
Malaria prophylaxis in travellers to tropical Africa.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Mal | 1990 |
Failure of chloroquine prophylaxis for falciparum malaria in pregnant women in Madang, Papua New Guinea.
Topics: Animals; Chloroquine; Enzyme-Linked Immunosorbent Assay; Female; Malaria; Papua New Guinea; Parity; | 1990 |
Malaria: the path of drug resistance.
Topics: Animals; Chloroquine; Drug Resistance; Erythrocytes; Female; Humans; Malaria; Microscopy, Electron, | 1990 |
Continuation of chloroquine-susceptible Plasmodium falciparum parasitemia in volunteers receiving chloroquine therapy.
Topics: Administration, Oral; Adult; Animals; Chloroquine; Humans; Liver; Malaria; Male; Plasmodium falcipar | 1990 |
Sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine in Nigerian children.
Topics: Animals; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Malaria; Nigeria | 1990 |
[Uncomplicated attack of malaria in an area with high resistance to chloroquine. I. Evaluation of a short treatment with quinine].
Topics: Adolescent; Animals; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans | 1990 |
[Cross resistance to mefloquine and halofantrine in a case of P. falciparum malaria contracted in Sierra Leone].
Topics: Adult; Animals; Antimalarials; Chloroquine; Cross Reactions; Drug Resistance; Humans; Malaria; Male; | 1990 |
[Uncomplicated malaria attack in an area with high chloroquine resistance. 2. Evaluation of first-choice therapeutic scheme].
Topics: Amodiaquine; Animals; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Human | 1990 |
[Uncomplicated malaria attack in an area with high resistance to chloroquine. 3. The use of second-choice oral drug treatment].
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Re | 1990 |
Reactive oxygen species generation by Kupffer cells and blood monocytes of mice infected with Plasmodium berghei and the chloroquine treatment.
Topics: Animals; Chloroquine; Kupffer Cells; Luminescent Measurements; Malaria; Mice; Mice, Inbred Strains; | 1990 |
[Look systematically for malaria in exposed children].
Topics: Adoption; Animals; Child, Preschool; Chloroquine; Emigration and Immigration; Female; Humans; Infant | 1990 |
[Cerebral infarction in pernicious malaria. Diagnostic value of computed tomography].
Topics: Adult; Animals; Cerebral Infarction; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium | 1990 |
[Difficulties in the prevention of malaria in Spain continue].
Topics: Animals; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Plasmodium falciparum; Proguanil; | 1990 |
[The emergence of chloroquine-resistant malaria in Dakar, Senegal].
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; M | 1990 |
Congenital malaria: a case report of a preventable disease.
Topics: Adult; Animals; Antimalarials; Chloroquine; Female; Humans; Infant, Newborn; Malaria; Male; Plasmodi | 1990 |
World malaria situation, 1988. Division of Control of Tropical Diseases.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1990 |
Radical treatment of vivax malaria in Madhya Pradesh, India.
Topics: Adult; Animals; Child; Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium vi | 1990 |
In vitro susceptibilities of Plasmodium falciparum to compounds which inhibit nucleotide metabolism.
Topics: Animals; Antimalarials; Antimetabolites; Chloroquine; Drug Resistance, Microbial; Enzyme Inhibitors; | 1990 |
World malaria situation 1988. Part I. Overview.
Topics: Animals; Chloroquine; Drug Resistance; Global Health; Humans; Incidence; Malaria; Plasmodium falcipa | 1990 |
World malaria situation 1988. Part II. Asia.
Topics: Animals; Asia; Chloroquine; Disease Outbreaks; Drug Resistance; Humans; Incidence; Malaria; Plasmodi | 1990 |
Efficacies of chloroquine and pyrimethamine-sulphadoxine in a Nigerian population with chloroquine resistant P. falciparum malaria.
Topics: Animals; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Humans; Infant; Malaria; | 1990 |
Isolated malaria outbreak in Somalia: role of chloroquine-resistant Plasmodium falciparum demonstrated in Balcad epidemic.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Disease Outbreaks; Dose-Response R | 1990 |
Chloroquine-resistant Plasmodium falciparum malaria in the Kavango region of Namibia.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Namibia; Plasmodium falciparum | 1990 |
[Clinical evaluation of antimalarial drugs].
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Evaluation; Female; Humans; Malaria; Male; Plasmodi | 1990 |
[Assessment of a chloroquine-spiramycin combination in the treatment of malaria in an area of moderate resistance].
Topics: Child; Child, Preschool; Chloroquine; Drug Therapy, Combination; Female; Humans; Infant; Malaria; Ma | 1990 |
[Plasmodium falciparum drug resistance in the Congo. Evaluation of surveys carried out from 1985 to 1989].
Topics: Adolescent; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroqui | 1990 |
Status of Plasmodium falciparum resistance to chloroquine in Gujarat, Rajasthan and Maharashtra states of India.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falciparum | 1990 |
Chloroquine sensitivity of Plasmodium falciparum in Shankargarh block of Allahabad district (U.P.).
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; I | 1990 |
Relapse pattern of Plasmodium vivax in Kheda district, Gujarat.
Topics: Animals; Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium vivax; Primaquin | 1990 |
Effect of prior eradication of Plasmodium berghei infection on the foetal development and parasitaemic levels under the stress of pregnancy.
Topics: Animals; Body Weight; Chloroquine; Embryonic and Fetal Development; Female; Malaria; Mice; Plasmodiu | 1990 |
The Peruvian III strain of Plasmodium brasilianum in Saimiri sciureus boliviensis monkeys.
Topics: Animals; Anopheles; Chloroquine; Malaria; Mefloquine; Monkey Diseases; Recurrence; Saimiri | 1990 |
Treatment of chloroquine-resistant malaria with esters of cephalotaxine: homoharringtonine.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Harringtonines; Homoharringtonine; Malaria; Mi | 1990 |
A type of macular degeneration in adult Nigerians; a possible role of chloroquine.
Topics: Adult; Chloroquine; Female; Humans; Macular Degeneration; Malaria; Male; Nigeria; Pterygium; Retrosp | 1990 |
[Insufficiency of treatment with halofantrine in chloroquinoresistant Plasmodium falciparum malaria in Sierra Leone].
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria; Phenanthrenes; | 1990 |
Malaria in Nigeria: a revisit.
Topics: Age Factors; Animals; Child; Chloroquine; Female; Humans; Longitudinal Studies; Malaria; Male; Niger | 1990 |
Plasma chloroquine measurement in the evaluation of Plasmodium falciparum sensitivity.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1990 |
A case of P. falciparum malaria from Mali: failure of chloroquine chemoprophylaxis.
Topics: Adolescent; Animals; Chloroquine; Drug Resistance; Female; Humans; Malaria; Mali; Plasmodium falcipa | 1990 |
Studies on outbreak of malaria in Muliad village of Kheda district, Gujarat.
Topics: Animals; Chloroquine; Disease Outbreaks; Drug Resistance; Humans; India; Malaria; Mosquito Control; | 1990 |
Response of Plasmodium falciparum to chloroquine in a tribal area of Madhya Pradesh.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; I | 1990 |
The hyperreactive malarial splenomegaly syndrome in a European: has the treatment a modulatory effect on the immune system?
Topics: Chloroquine; Humans; Immune System; Malaria; Male; Middle Aged; Splenomegaly; Syndrome | 1990 |
Malaria research--what next?
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Mosquito Control; Plasmodium; Research Suppo | 1990 |
High-tech and low-tech: control strategies today.
Topics: Animals; Chloroquine; Humans; Malaria; Mosquito Control; Plasmodium; Vaccines; World Health Organiza | 1990 |
Cerebral malaria. Factors affecting outcome of treatment in a suboptimal clinical setting.
Topics: Adult; Brain Diseases; Chloroquine; Ethiopia; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Co | 1990 |
Plasmodium knowlesi induces alterations in phosphatidylcholine and phosphatidylethanolamine molecular species composition of parasitized monkey erythrocytes.
Topics: Animals; Chloroquine; Erythrocyte Membrane; Erythrocytes; Fatty Acids; Macaca fascicularis; Macaca m | 1990 |
[Chloroquine poisoning].
Topics: Adult; Africa; Antimalarials; Asia; Chloroquine; Drug Overdose; Humans; Malaria; Male; Norway; South | 1990 |
[Malaria on the Turkish Riviera].
Topics: Chloroquine; Humans; Malaria; Travel; Turkey | 1990 |
Plasmodium chabaudi: in vivo effects of Ca2+ antagonists on chloroquine-resistant and chloroquine-sensitive parasites.
Topics: Animals; Calcium Channel Blockers; Chloroquine; Diltiazem; Dose-Response Relationship, Drug; Drug In | 1990 |
The in-vitro and ex-vivo effects of chloroquine sulphate on platelet function: implications for malaria prophylaxis in patients with impaired haemostasis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Blood Coagulation Disorders; Blood Platelets; | 1990 |
Malaria prophylaxis in high-risk travelers.
Topics: Adult; Chloroquine; Humans; Malaria; Travel | 1990 |
Effect of Plasmodium yoelii infection on GABA metabolism of mouse brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Chloroquine; gamma-Aminobutyric Acid; Glutamate Decarb | 1990 |
Prospective in vitro testing for drug-induced neutropenia in a patient requiring anti-malarial prophylaxis: confirmation of findings on exposure of patient to drug.
Topics: Agranulocytosis; Bone Marrow; Cells, Cultured; Chloroquine; Colony-Forming Units Assay; Humans; Mala | 1990 |
[Congenital malaria--a rare neonatal infection].
Topics: Animals; Cesarean Section; Chloroquine; Diseases in Twins; Female; Humans; Infant, Newborn; Malaria; | 1990 |
Public-health epidemiology in Vanuatu.
Topics: Adolescent; Anemia; Animals; Cardiovascular Diseases; Child; Child, Preschool; Chloroquine; Drug Res | 1990 |
Effect of malaria chemoprophylaxis on the development of antibodies to Plasmodium falciparum in expatriates living in west Africa.
Topics: Adolescent; Adult; Africa, Western; Aged; Animals; Antibodies, Protozoan; Antigens, Protozoan; Chi-S | 1990 |
Microscopic and flow cytophotometric analysis of parasitemia in cultures of Plasmodium falciparum vitally stained with Hoechst 33342--application to studies of antimalarial agents.
Topics: Antimalarials; Benzimidazoles; Chloroquine; Cyclosporins; DNA; Erythrocytes; Flow Cytometry; Fluores | 1986 |
[Effects of chloroquine on polyamines and nucleic acid of malaria parasites].
Topics: Animals; Chloroquine; DNA; Erythrocytes; Malaria; Male; Mice; Plasmodium; Plasmodium berghei; Polyam | 1987 |
Clinical profile of malaria in children--a prospective study from Aligarh (N. India).
Topics: Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falciparum | 1987 |
Reversal of chloroquine resistance in falciparum malaria independent of calcium channels.
Topics: Animals; Calcium; Chloroquine; Drug Interactions; Drug Resistance; Gallopamil; Ion Channels; Malaria | 1988 |
[Quantitative evaluation of parasitemia in tropical malaria].
Topics: Animals; Blood; Chloroquine; Humans; Malaria; Plasmodium falciparum | 1988 |
Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria.
Topics: Animals; Antimalarials; Chloroquine; DNA; Drug Resistance; Drug Therapy, Combination; Eflornithine; | 1989 |
Health assessment of the population affected by flood conditions--Khartoum, Sudan.
Topics: Child, Preschool; Chloroquine; Diarrhea; Disasters; Health; Health Status; Humans; Infant; Malaria; | 1989 |
[Chloroquine-resistant Plasmodium falciparum malaria confirmed by semi-micro sensitivity test for chloroquine seen in a person returned from Nigeria to Japan].
Topics: Adult; Animals; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria; Male; Nigeria; Pla | 1989 |
[Suspected convulsion-inducing effect of chloroquine (Resochin)].
Topics: Adult; Chloroquine; Epilepsies, Partial; Female; Humans; Malaria; Recurrence | 1989 |
[Failure of antimalarial prophylaxis by chloroquine in Niger].
Topics: Adult; Animals; Chloroquine; Female; Humans; Malaria; Male; Niger; Plasmodium falciparum | 1989 |
[Severe chloroquine-resistant Plasmodium falciparum malaria acquired in Senegal].
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparum; Senegal | 1989 |
Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria.
Topics: Adolescent; Adult; Animals; Child; Chloroquine; Erythrocytes; Female; Humans; Kinetics; Malaria; Mal | 1989 |
Formulation of malaria treatment policy for children in Côte d'Ivoire as chloroquine resistant Plasmodium falciparum spreads into west Africa.
Topics: Animals; Child, Preschool; Chloroquine; Cote d'Ivoire; Dose-Response Relationship, Drug; Drug Resist | 1989 |
Chloroquine-resistant Plasmodium falciparum in eastern Sudan.
Topics: Adolescent; Adult; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Middle Aged; Plasm | 1989 |
Transport proteins. Export-import family expands.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Drug Resistance; Huma | 1989 |
Plasmodium vivax resistance to chloroquine?
Topics: Acute Disease; Animals; Antimalarials; Blood Specimen Collection; Chloroquine; Dapsone; Drug Adminis | 1989 |
Chloroquine-resistant Plasmodium vivax.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium vivax; Primaquine | 1989 |
Malaria control by antivectorial measures in a zone of chloroquine-resistant malaria: a successful programme in a rice growing area of the Rusizi valley.
Topics: Animals; Burundi; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Insecticides; Malar | 1989 |
[The role of mefloquine in the prevention of malaria].
Topics: Africa; Chloroquine; Drug Resistance, Microbial; Drug Tolerance; France; Humans; Malaria; Mefloquine | 1989 |
Home treatment of febrile children with antimalarial drugs in Togo.
Topics: Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Fever; Home Nursing; Humans; | 1989 |
Decreased sensitivity of artesunate and chloroquine of Plasmodium falciparum infecting hemoglobin H and/or hemoglobin constant spring erythrocytes.
Topics: Animals; Artemisinins; Artesunate; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance, M | 1989 |
The response of Plasmodium falciparum to chloroquine and mefloquine in Bandar-Abbas and Minab areas, Hormozgan Province, southern Iran.
Topics: Adolescent; Adult; Animals; Child; Chloroquine; Drug Resistance; Humans; Iran; Malaria; Mefloquine; | 1989 |
Chemoprophylaxis and treatment of malaria.
Topics: Animals; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Plasmodium falciparum; Proguanil | 1989 |
[Comparative efficacy of alternative treatments in Plasmodium falciparum infections in Zaire].
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Democratic Republic of the Congo; Drug Resist | 1989 |
Therapeutic effect of chloroquine(CQ)-containing immunoliposomes in rats infected with Plasmodium berghei parasitized mouse red blood cells: comparison with combinations of antibodies and CQ or liposomal CQ.
Topics: Animals; Antibodies, Monoclonal; Chloroquine; Erythrocyte Membrane; Erythrocytes; Immunoglobulin Fab | 1989 |
Low response of Colombian strains of Plasmodium vivax to classical antimalarial therapy.
Topics: Adult; Aged; Amodiaquine; Animals; Chloroquine; Colombia; Drug Resistance; Drug Therapy, Combination | 1989 |
[Surveillance of Plasmodium falciparum drug sensitivity in Yaounde and its surroundings (Cameroon). In vivo and in vitro study].
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chloroqui | 1989 |
Response of Plasmodium falciparum to chloroquine treatment: relation to whole blood concentrations of chloroquine and desethylchloroquine.
Topics: Adolescent; Animals; Child; Chloroquine; Humans; Malaria; Plasmodium falciparum | 1989 |
Antimalarial drug susceptibility of Plasmodium falciparum isolates from forest fringe dwelling aborigines (Orang Asli) of Peninsular Malaysia.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Malaria; Malaysia; Mefloquine; | 1989 |
[An uncommon complication of chloroquine resistant Plasmodium falciparum malaria: spontaneous splenic rupture].
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparum; Rupture, | 1989 |
[Malaria in Gabon. Bioclinical survey of non immune Europeans during short stay and prophylactic attitude].
Topics: Adult; Animals; Antibodies, Protozoan; Chloroquine; Drug Resistance; Europe; Fluorescent Antibody Te | 1989 |
[Malaria in Guiana. I. General status of the endemic].
Topics: Adolescent; Adult; Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Fren | 1989 |
Chloroquine containing liposomes in the chemotherapy of murine malaria.
Topics: Animals; Chloroquine; Drug Carriers; Injections, Intraperitoneal; Liposomes; Malaria; Male; Mice; Pl | 1989 |
Antimalarial activity of new floxacrine-related acridinedione derivatives: studies on blood schizontocidal action of potential candidates against P. berghei in mice and P. falciparum in vivo and in vitro.
Topics: Acridines; Animals; Antimalarials; Cebidae; Chloroquine; Drug Resistance; Female; Malaria; Male; Mic | 1989 |
Chloroquine in the treatment of malaria.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Quinine | 1989 |
Chloroquine resistant imported Plasmodium falciparum in an industrial complex at Hardwar (U.P.).
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falciparum | 1989 |
Efficacy of 5 day radical treatment of primaquine in Plasmodium vivax cases at the BHEL industrial complex, Hardwar (U.P.).
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Malaria; M | 1989 |
Drug resistant P. falciparum in Madras (Tamil Nadu) and district Jabalpur (Madhya Pradesh).
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; I | 1989 |
[Development of chloroquine resistance in Plasmodium falciparum in Gabon between 1984 and 1987-88 (in vivo evaluation in a school environment)].
Topics: Animals; Chloroquine; Drug Resistance; Gabon; Malaria; Plasmodium falciparum; Rural Population; Urba | 1989 |
[In vivo chemosensitivity of Plasmodium falciparum in the Islamic Federal Republic of the Comoros].
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Indian Ocean Isl | 1989 |
Chloroquine sensitivity of P. falciparum in Koraput district, Orissa.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falciparum | 1989 |
A focus of high degree chloroquine resistant P. falciparum in Mandla district (M.P.).
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; F | 1989 |
Chloroquine-resistant malaria in Jos, Nigeria.
Topics: Adolescent; Animals; Brain Diseases; Chloroquine; Drug Resistance; Humans; Malaria; Male; Nigeria; P | 1989 |
[A very severe Plasmodium falciparum infection in spite of malaria prophylaxis].
Topics: Animals; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Male; Middle Aged | 1989 |
Chloroquine blood levels after administration of the liposome-encapsulated drug in relation to therapy of murine malaria.
Topics: Animals; Chloroquine; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Injections, Intraperitoneal; | 1989 |
Chloroquine resistance in Plasmodium falciparum in KwaZulu, 1983-1988.
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Malaria; Plasmodium falcipa | 1989 |
[Experimental studies on the incubation period and relapse patterns in vivax malaria in west Hunan].
Topics: Animals; Chloroquine; Humans; Malaria; Plasmodium vivax; Recurrence | 1989 |
[Field observation on the relapse pattern in patients naturally infected with vivax malaria from spring to autumn seasons in Cili County, Hunan Province].
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Plasmodium vivax; Recurrence; Seasons | 1989 |
Menhaden-fish oil in a vitamin E-deficient diet: protection against chloroquine-resistant malaria in mice.
Topics: Animals; Chloroquine; Diet; Drug Resistance; Fish Oils; Malaria; Male; Mice; Plasmodium falciparum; | 1989 |
The chemotherapy of rodent malaria. XLIV. Studies on the mode of action of CM 6606, an indolo (3,2-c) quinoline N-oxide.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Indoles; Malaria; Male; Mice; Microscopy, Elec | 1989 |
The potentiating action of tetrandrine in combination with chloroquine or qinghaosu against chloroquine-sensitive and resistant falciparum malaria.
Topics: Alkaloids; Animals; Antimalarials; Artemisinins; Benzylisoquinolines; Chloroquine; Drug Resistance; | 1989 |
Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children.
Topics: Anemia; Animals; Blinking; Brain Diseases; Child; Child, Preschool; Chloroquine; Coma; Female; Human | 1989 |
Efficacy of chloroquine in the treatment of malaria in children under five years in Baissa (Gongola State, Nigeria).
Topics: Animals; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria; Nigeria; Plasmodiu | 1989 |
Antagonism of serum of mice infected with chloroquine-resistant 'NS' line to the antimalarial action of chloroquine.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Malaria; Male; Mice; Plasmodium | 1989 |
[Malaria morbidity at the Center for Maternal and Child Prevention of the Central Hospital, Yaounde, Cameroon. Observations of a sample of 903 infants].
Topics: Animals; Cameroon; Child; Child, Preschool; Chloroquine; Humans; Infant; Malaria; Plasmodium falcipa | 1989 |
Integrated malaria control achieves results in Mayotte.
Topics: Animals; Chloroquine; Disease Vectors; Humans; Indian Ocean Islands; Malaria; Mosquito Control; Plas | 1989 |
Falciparum malaria--present day problems. An experience with 425 cases.
Topics: Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Chloroquine; Female; Humans; India; Infan | 1989 |
A longitudinal study of P. falciparum response to chloroquine in relation to the epidemiology.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Longitudinal Studies; Malaria; Plasmodium falc | 1989 |
Therapeutic failure with chloroquine in Plasmodium falciparum infections; possibility of high grade resistance.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparum | 1989 |
Febrile illness in an Afghani "freedom fighter".
Topics: Administration, Oral; Adult; Afghanistan; Animals; Chloroquine; Emigration and Immigration; Fever; H | 1989 |
A study on tropical splenomegaly syndrome and chloroquine prophylaxis.
Topics: Adolescent; Adult; Animals; Chloroquine; Female; Humans; India; Malaria; Male; Middle Aged; Plasmodi | 1989 |
[Malaria in Ile de Sainte Marie in 1988. Epidemiological approach. Chloroquine sensitivity of Plasmodium falciparum].
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Madagascar | 1989 |
[The treatment of Plasmodium falciparum malaria in the Malagasy Highland Plateaux. Development of fever and parasite density. Clinical aspects].
Topics: Animals; Chloroquine; Humans; Madagascar; Malaria; Microbial Sensitivity Tests; Plasmodium falciparu | 1989 |
Status of the response of Plasmodium falciparum to chloroquine and mefloquine in Iran.
Topics: Afghanistan; Animals; Chloroquine; Drug Resistance; Female; Humans; India; Iran; Malaria; Male; Mefl | 1989 |
Localization of the focus of origin of resistance in Plasmodium falciparum.
Topics: Animals; Chloroquine; Drug Resistance; India; Malaria; Plasmodium falciparum | 1989 |
Chloroquine overdosage in infancy: a case report.
Topics: Africa; Chloroquine; Female; Humans; Infant; Kansas; Malaria; Travel | 1989 |
[A study of the efficacy of the chemoprevention of malaria using chlorproguanil alone or in combination with chloroquine in French expatriates in Dar-es-Salaam, Tanzania].
Topics: Adolescent; Adult; Child; Chloroquine; Drug Therapy, Combination; Female; France; Humans; Malaria; M | 1989 |
[The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission].
Topics: Adolescent; Animals; Anopheles; Burkina Faso; Child; Child, Preschool; Chloroquine; Dose-Response Re | 1989 |
Curative and preventive treatment of uncomplicated malaria in public health institutions in Cameroon.
Topics: Amodiaquine; Antimalarials; Cameroon; Child; Chloroquine; Drug Combinations; Female; Humans; Malaria | 1989 |
Progress and problems in the diagnosis and treatment of malaria and development of an effective referral system in Papua New Guinea.
Topics: Amodiaquine; Chloroquine; Humans; Laboratories; Malaria; Papua New Guinea; Referral and Consultation | 1989 |
[A case of chloroquinoresistance of Plasmodium falciparum in Ivory Coast].
Topics: Adult; Animals; Chloroquine; Cote d'Ivoire; Drug Resistance; Female; Humans; Malaria; Plasmodium fal | 1988 |
Effect of stress conditions on the course of trophozoite-induced Plasmodium yoelii nigeriensis in mice recently cured of a previous infection.
Topics: Animals; Chloroquine; Malaria; Male; Mice; Plasmodium yoelii; Stress, Physiological; Temperature; Ti | 1988 |
Chloroquine-resistant Plasmodium falciparum malaria from Ivory Coast.
Topics: Adult; Animals; Chloroquine; Cote d'Ivoire; Drug Resistance; Humans; Malaria; Male; Plasmodium falci | 1988 |
Chloroquine and Fansidar resistant malaria acquired in Angola.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum; Sulfad | 1985 |
Chloroquine-resistant Plasmodium falciparum in Cameroon.
Topics: Cameroon; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; P | 1985 |
Unreliability of Dill Glazko test in detecting chloroquine in urine.
Topics: Adult; Child; Chloroquine; Colorimetry; Humans; Malaria | 1985 |
Chloroquine-resistant Plasmodium falciparum: now in Pakistani Punjab.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Pakistan; Plasmodium falciparum | 1985 |
Chloroquine-resistant malaria in Africa.
Topics: Africa; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1985 |
Transfusion-associated malaria.
Topics: Chloroquine; Humans; Malaria; Transfusion Reaction | 1985 |
Is plasmodium falciparum resistance to chloroquine reversible in absence of drug pressure?
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Drug Interactions; Drug Resistance, Microbial; Hum | 1985 |
Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria.
Topics: Administration, Oral; Adolescent; Adult; Amodiaquine; Child; Chloroquine; Drug Combinations; Drug Re | 1985 |
Chloroquine-resistant malaria in Mozambique.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Mozambique; Plasmodium falciparum | 1985 |
Chloroquine-resistant falciparum malaria in the Congo.
Topics: Adult; Child; Child, Preschool; Chloroquine; Congo; Drug Resistance, Microbial; Humans; Malaria; Mid | 1985 |
Chloroquine and amodiaquine resistant falciparum malaria in Rwanda.
Topics: Amodiaquine; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Rwanda | 1985 |
Does chloroquine contribute to the risk of serious adverse reactions to fansidar?
Topics: Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Pyrimethamine; Skin Dise | 1985 |
In vivo chloroquine-resistant falciparum malaria in western Africa.
Topics: Adult; Africa, Western; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Mal | 1986 |
Chloroquine-resistant Plasmodium falciparum malaria in Ethiopia.
Topics: Adolescent; Adult; Chloroquine; Drug Resistance, Microbial; Ethiopia; Female; Humans; Malaria; Male; | 1986 |
Chloroquine-resistant falciparum malaria in Benin.
Topics: Benin; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1986 |
Chloroquine for donated blood?
Topics: Blood Donors; Chloroquine; Humans; Malaria | 1987 |
Appearance of chloroquine-resistant falciparum malaria in Swaziland.
Topics: Child, Preschool; Chloroquine; Drug Resistance, Microbial; Eswatini; Humans; Malaria; Plasmodium fal | 1987 |
Does chloroquine cause hypoglycaemia in the absence of clinical malaria?
Topics: Adult; Blood Glucose; Child; Child, Preschool; Chloroquine; Humans; Hypoglycemia; Infant; Malaria; M | 1987 |
Chloroquine-induced pruritus in Nigerian medical and nursing students.
Topics: Administration, Oral; Adult; Chloroquine; Female; Histamine H1 Antagonists; Humans; Injections, Intr | 1986 |
High rate of Plasmodium vivax relapse following treatment of falciparum malaria in Thailand.
Topics: Acute Disease; Adolescent; Adult; Animals; Antimalarials; Chloroquine; Female; Follow-Up Studies; Hu | 1987 |
Failure of dapsone/pyrimethamine plus chloroquine against falciparum malaria in Papua New Guinea.
Topics: Adult; Animals; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; | 1988 |
Compliance with malaria chemoprophylaxis programmes in Zimbabwe.
Topics: Chloroquine; Dapsone; Humans; Malaria; Patient Compliance; Pyrimethamine; Zimbabwe | 1987 |
Malaria chemoprophylaxis and traveller's weight.
Topics: Body Weight; Chloroquine; Humans; Malaria; Retrospective Studies; Travel | 1988 |
Resistant malaria and the Sudan floods.
Topics: Adult; Child; Chloroquine; Disasters; Drug Resistance; Humans; Ill-Housed Persons; Malaria; Sudan | 1988 |
Floods and resistant malaria.
Topics: Animals; Child; Child, Preschool; Chloroquine; Disasters; Drug Resistance; Female; Humans; Infant; I | 1988 |
Reported illness and compliance in US travelers attending an immunization facility.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chloroquine; Diarrhea; Female; Humans; Malaria; Ma | 1989 |
An unusual combination of phototoxicity and Stevens-Johnson syndrome due to antimalarial therapy.
Topics: Antimalarials; Child; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Ma | 1989 |
Effect of a malaria suppression program on the incidence of African Burkitt's lymphoma.
Topics: Adolescent; Age Factors; Burkitt Lymphoma; Child; Child, Preschool; Chloroquine; Female; Humans; Inf | 1989 |
Erythroderma resembling sézary syndrome after treatment with Fansidar and chloroquine.
Topics: Antimalarials; Chloroquine; Dermatitis, Exfoliative; Drug Combinations; Humans; Malaria; Male; Middl | 1986 |
Severe cutaneous reactions among American travelers using pyrimethamine-sulfadoxine (Fansidar) for malaria prophylaxis.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Eruptions; Eryth | 1986 |
[Chloroquine-resistant Plasmodium falciparum in Togo. A case].
Topics: Adult; Animals; Chloroquine; Drug Resistance; Female; Humans; Malaria; Plasmodium falciparum; Togo | 1987 |
Plasmodium berghei: lymphocyte and macrophage dynamics in the spleen of Balb/c mice in the course of infection and after rechallenge of cured mice.
Topics: Animals; B-Lymphocytes; Chloroquine; Female; Lymphocyte Activation; Macrophages; Malaria; Mice; Mice | 1988 |
[Extension to western Africa of the drug resistance of Plasmodium Falciparum].
Topics: Adolescent; Adult; Africa, Western; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Pl | 1988 |
[Chloroquinoresistant malaria after coming from Ghana].
Topics: Aged; Animals; Chloroquine; Drug Resistance, Microbial; Female; Ghana; Humans; Malaria; Plasmodium f | 1988 |
[Fatal pernicious attack due to chloroquinoresistant Plasmodium falciparum on return from Burkina Faso. 1 case].
Topics: Aged; Animals; Burkina Faso; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium falcipa | 1988 |
A preliminary report of epidemiological studies of Burkitt's lymphoma, Epstein-Barr virus infection and malaria in North Mara, Tanzania.
Topics: Adolescent; Age Factors; Antibodies, Viral; Burkitt Lymphoma; Child; Child, Preschool; Chloroquine; | 1985 |
Need for malaria prophylaxis by travelers to areas with chloroquine-resistant Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Centers for Disease Control and Prevention, U.S.; Chloroquine; Drug | 1986 |
Leads from the MMWR. Need for malaria prophylaxis by travelers to areas with chloroquine-resistant Plasmodium falciparum.
Topics: Africa; Antimalarials; Centers for Disease Control and Prevention, U.S.; Chloroquine; Drug Combinati | 1986 |
[Chemoresistance of Plasmodium falciparum in Kinshasha. In vivo tests and chloroquine absorption].
Topics: Absorption; Adolescent; Adult; Animals; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; | 1988 |
Response of Kampuchean strains of Plasmodium falciparum to antimalarials: in-vivo assessment of quinine and quinine plus tetracycline; multiple drug resistance in vitro.
Topics: Adolescent; Adult; Animals; Cambodia; Chloroquine; Drug Administration Schedule; Drug Resistance; Dr | 1988 |
A model for Plasmodium falciparum sporozoite challenge and very early therapy of parasitaemia for efficacy studies of sporozoite vaccines.
Topics: Adult; Animals; Chloroquine; Humans; Malaria; Male; Models, Biological; Plasmodium falciparum; Vacci | 1988 |
A study on chloroquine resistant falciparum malaria in a rural population in Ghana.
Topics: Animals; Child, Preschool; Chloroquine; Drug Resistance; Ghana; Humans; Malaria; Plasmodium falcipar | 1988 |
[The chloroquine resistance of Plasmodium falciparum in Vanuatu (1980-1984): appearance, evolution, distribution].
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Culture Media; Drug Resistance; Hu | 1988 |
A quantitative approach to recommendations on malaria prophylaxis.
Topics: Animals; Antimalarials; Chloroquine; Decision Trees; Drug Resistance; Humans; Malaria; Plasmodium fa | 1988 |
[Emergence of chloroquine-resistant malaria in West Africa: the case of Sokode (Togo)].
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falcipar | 1988 |
[Drug-resistant malaria in France].
Topics: Africa; Animals; Chloroquine; Drug Resistance; France; Humans; Malaria; Plasmodium falciparum | 1988 |
The Plasmodium falciparum chloroquine in vivo test: extended follow-up is more important than parasite counting.
Topics: Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Methods; Plasmodium falciparum | 1988 |
[Antimalarial activities: the last 40 years. Antimalarial action program].
Topics: Animals; Anopheles; Chloroquine; Developing Countries; Drug Resistance; Humans; Insecticide Resistan | 1988 |
Mepacrine accumulation during treatment of chloroquine-resistant falciparum malaria.
Topics: Adolescent; Adult; Animals; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Middle Aged | 1988 |
If I had an attack of malaria.
Topics: Animals; Chloroquine; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax | 1988 |
[Low levels of chloroquine resistance of Plasmodium falciparum in the province of Zou in Benin].
Topics: Animals; Benin; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria; Plas | 1988 |
[In vitro sensitivity of Plasmodium falciparum to chloroquine in the highland region of Madagascar in 1987].
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Madagascar; Malaria; Plasmod | 1988 |
DNA hybridization for assessment of response of Plasmodium falciparum to chloroquine therapy.
Topics: Animals; Child, Preschool; Chloroquine; Densitometry; DNA; DNA Probes; Humans; Infant; Malaria; Nucl | 1988 |
Cerebral malaria from West Africa: chloroquine-resistant Plasmodium falciparum?
Topics: Adult; Africa, Western; Animals; Brain Diseases; Chloroquine; Drug Resistance; Humans; Malaria; Male | 1988 |
Serial studies on the evolution of drug resistance in malaria in an area of east Africa: findings from 1979 up to 1986.
Topics: Age Factors; Amodiaquine; Animals; Antibodies, Protozoan; Antimalarials; Child; Child, Preschool; Ch | 1988 |
Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Administration Schedule; Humans; Hypotension; In | 1988 |
Malaria prophylaxis.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; New Zealand; Plasmodium falciparum; Quinine | 1988 |
In vivo and in vitro sensitivity of Plasmodium falciparum to chloroquine at Lubwe and Kalene in Zambia: use of amodiaquine as an alternative antimalarial drug.
Topics: Adolescent; Amodiaquine; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium f | 1988 |
Susceptibility of Plasmodium falciparum to chloroquine and mefloquine in Somalia.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; I | 1988 |
[Transfusion malaria in promyelocytic leukemia].
Topics: Adult; Animals; Chloroquine; Drug Therapy, Combination; Erythrocyte Transfusion; Female; Humans; Leu | 1988 |
[An imported case of malaria resistant to chloroquine].
Topics: Animals; Cameroon; Child; Child, Preschool; Chloroquine; Doxycycline; Drug Combinations; Drug Resist | 1988 |
Malaria chemoprophylaxis with a proguanil-chloroquine-maloprim combination in Papua New Guinea.
Topics: Animals; Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; | 1988 |
Low prevalence of P. falciparum in-vivo resistance to chloroquine in northern Cameroon in 1986.
Topics: Adolescent; Adult; Animals; Cameroon; Child; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodi | 1988 |
Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Aotus trivirgatus; Chloroquine; Desipramine; Dose-Respons | 1988 |
In vitro confirmation of chloroquine-resistant Plasmodium falciparum malaria in KwaZulu.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; South Africa | 1988 |
Problems of chloroquine-resistant plasmodium falciparum.
Topics: Adolescent; Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Middle Aged; Plasmodium f | 1988 |
Malaria and its prevention in British residents visiting west Africa.
Topics: Adult; Africa, Western; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Huma | 1988 |
[Comments on the Second Session on Prevention of Travelers' Malaria. Ecole du Val de Grace (Paris), 9-10 October 1987].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Health Policy; Humans; Malaria; Plasmodium fal | 1988 |
Response of children with Plasmodium falciparum to chloroquine and development of a national malaria treatment policy in Zaire.
Topics: Animals; Child, Preschool; Chloroquine; Democratic Republic of the Congo; Drug Resistance; Female; H | 1988 |
Chloroquine-resistant falciparum malaria from Guinea.
Topics: Adult; Africa, Western; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium fal | 1988 |
Failure of erythromycin to improve chloroquine treatment of Plasmodium falciparum malaria in Kenya.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Therapy, Combination; Erythromycin; Humans; Infa | 1988 |
The first report of Plasmodium falciparum resistant to chloroquine plus sulphadoxine/pyrimethamine in Rwanda.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combin | 1988 |
In vitro drug sensitivity of Plasmodium falciparum malaria from Nigeria.
Topics: Adolescent; Adult; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Middle Aged; Niger | 1988 |
Chloroquine treatment of malaria does not increase antibody response to measles vaccination. A controlled study of 580 rural children living in an endemic malaria area.
Topics: Animals; Antibodies, Viral; Child, Preschool; Chloroquine; Humans; Infant; Malaria; Measles; Measles | 1988 |
Chloroquine-resistant Plasmodium falciparum malaria in Punjab (northern India.
Topics: Animals; Chloroquine; Drug Resistance; India; Malaria; Plasmodium falciparum | 1988 |
[Malaria in employees of an African industrial enterprise (Bobo Dioulasso, Burkina Faso)].
Topics: Adult; Animals; Antibodies, Protozoan; Burkina Faso; Chloroquine; Chromatography, High Pressure Liqu | 1988 |
Hypnozoites in Bradford.
Topics: Animals; Child, Preschool; Chloroquine; England; Fever; Humans; Infant, Newborn; Malaria; Male; Plas | 1988 |
Ineffectiveness of continuous quinidine gluconate infusion in the treatment of severe chloroquine-resistant Plasmodium falciparum malaria.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Infusions, Intravenous; Malaria; Male; Middle Aged; P | 1988 |
[Malaria in a village of the high plateau area of Madagascar in 1987. Present status of Plasmodium falciparum sensitivity to chloroquine. In vitro study. Some epidemiologic findings].
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; M | 1988 |
Chloroquine-resistant Plasmodium falciparum malaria acquired in central Africa--Quebec.
Topics: Animals; Cameroon; Child; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparum | 1988 |
In-vivo susceptibility of Plasmodium falciparum to cholorquine in pregnant and non-pregnant women and in-vitro response of P. falciparum to chloroquine and mefloquine in Madang Province, Papua New Guinea.
Topics: Animals; Antimalarials; Chloroquine; Female; Humans; In Vitro Techniques; Malaria; Mefloquine; Papua | 1988 |
[Chloroquine and fansidar resistance of Plasmodium falciparum now also in Ghana].
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Ghana; Humans; Malar | 1988 |
Antiparasitic activity of nine pyrazole derivatives against Trichomonas vaginalis, Entamoeba invadens and Plasmodium berghei.
Topics: Animals; Chloroquine; Entamoeba; Female; In Vitro Techniques; Malaria; Metronidazole; Mice; Plasmodi | 1988 |
A comparison of the sensitivity of Plasmodium falciparum malaria to chloroquine in two areas of Isoka District--Zambia.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria; Pilot P | 1988 |
Chloroquine-resistant Plasmodium falciparum in Mali revealed by congenital malaria.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Infant, Newborn; Malari | 1988 |
Multiple drug resistant Plasmodium falciparum malaria in a pregnant indigenous Zambian woman.
Topics: Adult; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Erythro | 1988 |
Chloroquine treatment of falciparum malaria in an area of Kenya of intermediate chloroquine resistance.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Fever; Humans; Infant; Kenya; Malari | 1988 |
Symptoms and responses to chemotherapy in adult Malawians admitted to hospital with Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Animals; Chloroquine; Diarrhea; Female; Humans; Malaria; Malawi; Male; Middle Age | 1988 |
Epidemiological implications of population migration: Part II. Evidence of chloroquine resistant Plasmodium falciparum malaria in Kheda district, Gujarat.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falciparum; Population Dyn | 1988 |
Chloroquine resistant Plasmodium falciparum malaria in Calcutta. A case report.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum | 1988 |
[Imported malaria in Lombardia. A second review of hospitalized cases in 1981-1985].
Topics: Adult; Animals; Chloroquine; Drug Resistance; Female; Humans; Italy; Malaria; Male; Middle Aged; Pat | 1988 |
Chloroquine resistant Plasmodium falciparum malaria in Zimbabwe.
Topics: Adolescent; Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Plasmodiu | 1986 |
Outbreak of malaria imported from Kenya.
Topics: Adult; Animals; Chloroquine; Disease Outbreaks; Drug Resistance; Humans; Kenya; Louisiana; Malaria; | 1986 |
alpha-Difluoromethylornithine induces protective immunity in mice inoculated with Plasmodium berghei sporozoites.
Topics: Animals; Chloroquine; Eflornithine; Immunization; Malaria; Mice; Plasmodium berghei | 1986 |
Chloroquine-resistant Plasmodium falciparum malaria in West Africa.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Middle Aged; Nigeria; Plasmodium fal | 1987 |
[Vaccination before foreign travel].
Topics: Chloroquine; Communicable Disease Control; Humans; Malaria; Travel; Tropical Climate; Vaccination | 1987 |
Suppression of the chloroquine resistance of Plasmodium berghei by treatment of infected mice with a microsomal monooxygenase inhibitor.
Topics: Animals; Chloroquine; Copper; Cytochrome P-450 Enzyme Inhibitors; Drug Resistance; Enzyme Inhibitors | 1987 |
Chloroquine resistance of Plasmodium berghei: biochemical basis and countermeasures.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Chloroquine; Copper; Drug Resista | 1987 |
The state of ferriprotoporphyrin IX in malaria pigment.
Topics: Animals; Chloroquine; Drug Resistance; Heme; Hemin; Malaria; Mice; Osmotic Fragility; Peptide Hydrol | 1987 |
[A clinical evaluation of chloroquine on malaria in Japan].
Topics: Adult; Animals; Chloroquine; Drug Evaluation; Female; Humans; Japan; Malaria; Male; Middle Aged; Pla | 1987 |
Death despite malaria prophylaxis.
Topics: Adult; Animals; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum; Proguanil; Quinine; Trave | 1988 |
Recommendations for the prevention of malaria in travelers.
Topics: Antimalarials; Breast Feeding; Child; Chloroquine; DEET; Drug Resistance; Female; Government Publica | 1988 |
Death despite malaria prophylaxis.
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; | 1988 |
Death despite malaria prophylaxis.
Topics: Animals; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum; Quinine | 1988 |
Childhood chloroquine poisonings--Wisconsin and Washington.
Topics: Brain Diseases; Chloroquine; Diazepam; Drug Therapy, Combination; Epinephrine; Female; Humans; Infan | 1988 |
Prevention of malaria.
Topics: Chloroquine; Humans; Malaria; Proguanil | 1988 |
Black water fever in Multan.
Topics: Adolescent; Animals; Blackwater Fever; Chloroquine; Humans; Malaria; Male; Pakistan; Plasmodium falc | 1988 |
Revised recommendations for preventing malaria in travelers to areas with chloroquine-resistant Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Eruptions; Drug Resistance; Humans; Malaria; Pla | 1985 |
Leads from the MMWR. Revised recommendations for preventing malaria in travelers to areas with chloroquine-resistant Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Eruptions; Drug Resistance; Humans; Malaria; Pla | 1985 |
[Disorders of the erythrocyte oxidation state in Plasmodium falciparum malaria treated with chloroquine].
Topics: Chloroquine; Erythrocytes; Humans; Malaria; Oxidation-Reduction; Plasmodium falciparum | 1985 |
Malaria prophylaxis.
Topics: Chloroquine; Humans; Malaria; Travel | 1988 |
Cerebellar ataxia in patients with malaria treated with chloroquine.
Topics: Adult; Cerebellar Ataxia; Chloroquine; Humans; Malaria; Male | 1988 |
Chemoprophylaxis and treatment of malaria.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria | 1988 |
Self-medication with chloroquine for malaria prophylaxis in urban and rural Zimbabweans.
Topics: Adolescent; Adult; Age Factors; Aged; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; M | 1988 |
Malaria prophylaxis.
Topics: Chloroquine; Humans; Malaria | 1988 |
Chloroquine induced psychosis.
Topics: Child; Chloroquine; Female; Humans; Malaria; Male; Psychoses, Substance-Induced | 1988 |
A longitudinal study of splenomegaly in pregnancy in a malaria endemic area in Papua New Guinea.
Topics: Adolescent; Adult; Chloroquine; Female; Humans; Longitudinal Studies; Malaria; Papua New Guinea; Pre | 1988 |
Effect of cholesterol-rich diet on the susceptibility of rodent malarial parasites to chloroquine chemotherapy.
Topics: Animals; Chloroquine; Cholesterol, Dietary; Drug Resistance; Malaria; Mice; Plasmodium berghei | 1988 |
Chloroquine-resistant Plasmodium falciparum malaria from Cameroon.
Topics: Animals; Cameroon; Chloroquine; Drug Resistance; Female; Humans; Malaria; Middle Aged; Plasmodium fa | 1988 |
In-vivo sensitivity of Plasmodium falciparum to chloroquine in Zaria, Nigeria.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Evaluation; Female; Humans; Infant; Malaria; Mal | 1988 |
1,2,4-Trioxanes as potential antimalarial agents.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Malaria; Mice; Plasmodium berghe | 1988 |
[Malaria in childhood. Report of 26 cases].
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Infant; | 1988 |
[Congenital malaria. Presentation of 3 cases].
Topics: Animals; Chloroquine; Female; Humans; Infant, Newborn; Malaria; Male; Plasmodium vivax | 1988 |
Effect of trans(E)-clopenthixol on Plasmodium berghei in vivo.
Topics: Animals; Chloroquine; Clopenthixol; Female; Malaria; Mice; Plasmodium berghei; Thioxanthenes | 1988 |
Drug resistance in Plasmodium falciparum malaria--a clinical study.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1988 |
Concurrent chloroquine and Fansidar resistance of Plasmodium falciparum: an imported case from Gabon.
Topics: Animals; Chloroquine; Drug Combinations; Drug Resistance; Gabon; Malaria; Mefloquine; Plasmodium fal | 1988 |
Pharmacokinetics of chloroquine in Thais: plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria.
Topics: Adolescent; Adult; Animals; Chloroquine; Electrocardiography; Erythrocytes; Female; Hemodynamics; Hu | 1988 |
Development of recommendations for the protection of short-stay travellers to malaria endemic areas: Memorandum from two WHO Meetings.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Policy | 1988 |
[Tropical malaria is no longer simple to prevent].
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Travel; Tropica | 1987 |
[Development of a qinghaosu-resistant line of Plasmodium berghei ANKA and N strain].
Topics: Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Drug Resistance, Microbia | 1986 |
Severe falciparum malaria.
Topics: Adult; Aged; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Plasmodium falc | 1987 |
Whole blood concentrations of chloroquine and desethylchloroquine during and after treatment of adult patients infected with Plasmodium vivax, P. ovale or P. malariae.
Topics: Adult; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Plasmodium malariae; Plasmodium viva | 1986 |
Failure of malaria chemoprophylaxis with a proguanil-chloroquine combination in Papua New Guinea.
Topics: Chloroquine; Drug Therapy, Combination; Humans; Malaria; Male; Papua New Guinea; Plasmodium falcipar | 1986 |
Epidemiology of imported malaria in a hospital in Milan, Italy.
Topics: Chloroquine; Drug Resistance; Humans; Italy; Malaria; Plasmodium falciparum; Travel | 1986 |
High level of chloroquine resistance in seven Plasmodium falciparum malaria cases from the Congo and Gabon.
Topics: Chloroquine; Congo; Drug Resistance; Gabon; Humans; Malaria; Plasmodium falciparum | 1986 |
Severe chloroquine-resistant falciparum malaria in Gabon with decreased sensitivity to quinine.
Topics: Adult; Chloroquine; Drug Resistance; Female; Gabon; Humans; Malaria; Male; Middle Aged; Plasmodium f | 1986 |
A fluorometric sensitivity test for chloroquine in Plasmodium falciparum isolates from patients.
Topics: Animals; Chloroquine; Drug Resistance; Ethidium; Fluorometry; Humans; Kenya; Malaria; Philippines; P | 1987 |
A study of the sensitivity of Plasmodium falciparum to chloroquine and mefloquine using the in vitro microtechnique in Peninsular Malaysia.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Malaysia; Mefloquine; Parasitology; Pl | 1987 |
Failure of chloroquine malaria prophylaxis in pregnancy.
Topics: Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Papua New Guinea; Parity; Plasmodi | 1987 |
[Chemical resistance of Plasmodium falciparum in Africa. Current situation, implications for chemoprophylaxis].
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1987 |
[Effect of chemoprophylaxis or chemotherapy with chloroquine on the acquisition of antimalarial fluorescent antibodies in the savannah area].
Topics: Antibodies; Burkina Faso; Child; Child, Preschool; Chloroquine; Fluorescent Antibody Technique; Huma | 1987 |
In vivo chloroquine sensitivity of Plasmodium falciparum in South West Niger.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria; Niger; Plasmodium f | 1987 |
Quinine resistant falciparum malaria in Vanuatu? A case report.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria; Male; Melanesia; Pl | 1987 |
Clinical evaluation of antimalarial regimens in Japan.
Topics: Animals; Antimalarials; Chloroquine; Drug Therapy, Combination; Humans; Japan; Malaria; Plasmodium f | 1987 |
Plasmodium falciparum in Kinshasa, Zaire: in vitro drug susceptibility studies.
Topics: Animals; Child; Chloroquine; Democratic Republic of the Congo; Drug Resistance; Humans; Malaria; Pla | 1987 |
[Malaria imported from Equatorial Guinea caused by Plasmodium falciparum probably resistant to chloroquine].
Topics: Africa, Central; Animals; Child, Preschool; Chloroquine; Female; Humans; Malaria; Plasmodium falcipa | 1987 |
A case of Plasmodium falciparum infection resistant to chloroquine.
Topics: Adult; Animals; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria; Male; Plasmodium f | 1987 |
Failure of chloroquine treatment to prevent malaria in Americans in West Africa.
Topics: Adult; Animals; Chloroquine; Humans; Malaria; Plasmodium falciparum; Togo; United States | 1987 |
The activity of drug combinations against established infections of rodent malaria.
Topics: Animals; Antimalarials; Chloroquine; Dapsone; Drug Therapy, Combination; Malaria; Mice; Plasmodium b | 1987 |
[Scandinavian recommendations on prevention of malaria].
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium | 1987 |
In vitro drug response of Plasmodium falciparum in the Philippines: increased resistance to amodiaquine.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Mefloquine; Phil | 1987 |
Effect of artemisinin (qinghaosu) and chloroquine on drug-sensitive and drug-resistant strains of Plasmodium falciparum malaria: use of [2,8-3H]adenosine as an alternative to [G-3H]hypoxanthine in the assessment of in vitro antimalarial activity.
Topics: Adenosine; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Erythrocytes; Humans; | 1987 |
Chloroquine resistance in Plasmodium falciparum in Natal.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria; | 1987 |
Shigellosis at a Caribbean resort. Hamburger and North American origin as risk factors.
Topics: Adult; Animals; Cattle; Chloroquine; Disease Outbreaks; Dysentery, Bacillary; Feces; Food Contaminat | 1987 |
Plasma concentrations and toxicity of chloroquine after slow intravenous infusion in patients with falciparum malaria.
Topics: Adolescent; Adult; Animals; Chloroquine; Female; Humans; Infusions, Intravenous; Malaria; Male; Midd | 1987 |
Community-based malaria control in Saradidi, Kenya: description of the programme and impact on parasitaemia rates and antimalarial antibodies.
Topics: Animals; Antibodies; Chloroquine; Community Health Services; Drug Resistance; Enzyme-Linked Immunoso | 1987 |
Malaria chemoprophylaxis to pregnant women provided by community health workers in Saradidi, Kenya. II. Effect on parasitaemia and haemoglobin levels.
Topics: Adolescent; Adult; Animals; Chloroquine; Community Health Services; Female; Hemoglobins; Humans; Ken | 1987 |
Malaria chemoprophylaxis to pregnant women provided by community health workers in Saradidi, Kenya. III. Serologic studies.
Topics: Animals; Antibodies; Antibody Formation; Chloroquine; Community Health Services; Enzyme-Linked Immun | 1987 |
Changing response to chloroquine of Plasmodium falciparum in Saradidi, Kenya, from 1981 to 1984.
Topics: Animals; Chloroquine; Community Health Services; Dose-Response Relationship, Drug; Drug Resistance; | 1987 |
[Drug resistance of Plasmodium falciparum in the Congo. 2. Comparative study in vivo of chloroquine and amodiaquine in Brazzaville schoolchildren (November 1986)].
Topics: Amodiaquine; Animals; Child; Chloroquine; Congo; Drug Resistance; Female; Humans; Malaria; Male; Pla | 1987 |
[Status of drug resistance of Plasmodium falciparum in the Central African Republic. Results of studies carried out between 1984 and 1986].
Topics: Amodiaquine; Animals; Antimalarials; Central African Republic; Child; Child, Preschool; Chloroquine; | 1987 |
[Drug sensitivity of malaria in a population of children in Pointe-Noire, Congo, in the first half of 1986].
Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Congo; Drug R | 1987 |
[Drug resistance of Plasmodium falciparum malaria in Equatorial Africa. Apropos of cases observed at a military unit stationed in Gabon].
Topics: Adult; Animals; Chloroquine; Drug Resistance; France; Gabon; Humans; Malaria; Military Personnel; Pl | 1987 |
[2 cases of multiresistant Plasmodium falciparum malaria contracted in Douala with atypical clinical presentation].
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Cameroon; Chloroquine; Drug Combinations; Dr | 1987 |
[New focus of chloroquine-resistant malaria in a forestry zone in Cameroon].
Topics: Animals; Cameroon; Child; Chloroquine; Drug Resistance; Geography; Humans; Malaria; Plasmodium falci | 1987 |
[A case of chloroquine-resistant malaria of type R3 originating in Cameroon].
Topics: Africa, Western; Animals; Cameroon; Child; Chloroquine; Drug Resistance; Female; Humans; Malaria; Pl | 1987 |
[Surveillance of the sensitivity of Plasmodium falciparum to chloroquine in Western Africa: value of in vivo tests using 5 and 10 mg/kg].
Topics: Africa, Western; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Parasitology; Plasmo | 1987 |
[Sensitivity of Plasmodium falciparum to quinolines and therapeutic strategies: comparison of the situation in Africa and Madagascar between 1983 and 1986].
Topics: Amodiaquine; Angola; Animals; Antimalarials; Burkina Faso; Cameroon; Chloroquine; Drug Resistance; H | 1987 |
[Development of drug resistance in cases of P. falciparum malaria of African origin in a Parisian hospital. Comparison with field data and therapeutic consequences].
Topics: Africa; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; France | 1987 |
[Current aspects of imported drug-resistant Plasmodium falciparum].
Topics: Adult; Africa, Central; Aged; Aged, 80 and over; Amodiaquine; Animals; Antimalarials; Chloroquine; D | 1987 |
In vitro chloroquine-resistant falciparum malaria in Malabo, Equatorial Guinea: case reports.
Topics: Adolescent; Africa, Western; Animals; Chloroquine; Drug Resistance; Guinea-Bissau; Humans; Malaria; | 1987 |
In vitro monitoring of chloroquine sensitivity of Plasmodium falciparum in Ifakara, Kilombero District, south-east Tanzania.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Tanzania | 1987 |
Chloroquine resistance in Plasmodium falciparum and its geographical distribution in Papua New Guinea.
Topics: Adolescent; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria; Papua New Guinea; Plasmod | 1987 |
Compared response to chloroquine, fansidar, quinine, and quinidine slow release of infections with Plasmodium falciparum in the Kivu region of Zaire.
Topics: Animals; Antimalarials; Chloroquine; Delayed-Action Preparations; Democratic Republic of the Congo; | 1987 |
Chloroquine-resistant Plasmodium falciparum at two farms near Mhangura.
Topics: Animals; Child; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Malaria; Plasmodium falci | 1987 |
Congenital malaria (a report of 2 cases).
Topics: Adult; Animals; Chloroquine; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Malaria; Mal | 1987 |
Malaria in the Malaysian Army with particular reference to chemosuppressive use.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria; Malaysia; Male; Military Personnel; Plasmodi | 1987 |
In vivo response of Plasmodium falciparum to chloroquine in pregnant and non-pregnant women in Siaya District, Kenya.
Topics: Animals; Chloroquine; Female; Humans; Kenya; Malaria; Parity; Plasmodium falciparum; Pregnancy; Preg | 1987 |
Dynamics of P. falciparum ratio--an indication of malaria resistance or a result of control measures?
Topics: Animals; Asia, Southeastern; Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falcip | 1987 |
Report of a case of P. falciparum malaria resistant to chloroquine and combination of sulfalene and pyrimethamine in Delhi.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria; Mal | 1987 |
Risk in a national malaria control programme in Mali: underdosage of antimalarials.
Topics: Adolescent; Animals; Child; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Humans; | 1987 |
[Risk of infection with chemoresistant Plasmodium falciparum according to Anopheles density and infectivity. Application to West and Central Africa].
Topics: Africa, Central; Africa, Western; Animals; Anopheles; Chloroquine; Drug Resistance; Humans; Malaria; | 1987 |
Amodiaquine fails to cure chloroquine resistant Plasmodium falciparum in the Punjab.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Mefloquine; Paki | 1987 |
Reduction in erythrocytic GSH level and stability in Plasmodium vivax malaria.
Topics: Adolescent; Adult; Animals; Child; Chloroquine; Erythrocyte Count; Erythrocytes; Female; Glutathione | 1987 |
Antimalarial activity of bisdesethylchloroquine against P. falciparum and P. berghei berghei.
Topics: Animals; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Malaria; Mice; P | 1987 |
Effectiveness of single dose treatment with chloroquine of malaria in West Africa and measurement of chloroquine urinary excretion.
Topics: Adolescent; Animals; Child; Chloroquine; Colorimetry; Humans; Malaria; Plasmodium falciparum | 1987 |
Comparative efficacy of alternative primary therapies for Plasmodium falciparum infections in Malawi.
Topics: Amodiaquine; Animals; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Humans; Mal | 1987 |
Is chloroquine-resistant Plasmodium falciparum malaria emerging in Senegal or The Gambia?
Topics: Adult; Animals; Chloroquine; Drug Resistance; Female; Gambia; Humans; Malaria; Plasmodium falciparum | 1987 |
[In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of a study conducted on the east coast (July 1985-July 1986)].
Topics: Adolescent; Adult; Aminoquinolines; Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Drug | 1987 |
[In vivo and in vitro study of the chemosensitivity of Plasmodium falciparum in Madagascar--1982-1986].
Topics: Adolescent; Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Inf | 1987 |
Response of Plasmodium falciparum to chloroquine in hospital patients at Muheza, Tanzania.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Hospitali | 1986 |
In-vivo falciparum malaria response to chloroquine in Kisumu-Kenya.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Kenya; M | 1987 |
Chloroquine neuromyotoxicity.
Topics: Chloroquine; Humans; Malaria; Neuromuscular Junction | 1988 |
Liquid dosage form of chloroquine.
Topics: Chloroquine; Dosage Forms; Drug Stability; Humans; Malaria | 1988 |
Leads from the MMWR. Recommendations for the prevention of malaria in travelers.
Topics: Antimalarials; Breast Feeding; Child; Chloroquine; DEET; Drug Resistance; Female; Government Publica | 1988 |
Maternal administration of chloroquine: an unexplored aspect of malaria control.
Topics: Adult; Child; Child, Preschool; Chloroquine; Female; Gambia; Health Education; Home Nursing; Humans; | 1988 |
Fatal reaction by parenteral Lariago?--A case report.
Topics: Anaphylaxis; Child; Chloroquine; Drug Hypersensitivity; Female; Humans; Injections; Malaria | 1988 |
Malaria prophylaxis with proguanil to Namibian refugee children in Angola.
Topics: Angola; Child, Preschool; Chloroquine; Humans; Infant; Malaria; Namibia; Proguanil; Refugees | 1988 |
Differential effects of chloroquine on the phospholipid metabolism of Plasmodium-infected erythrocytes.
Topics: Animals; Chloroquine; Erythrocytes; Fatty Acids; Hypoxanthine; Hypoxanthines; Isoleucine; Macaca fas | 1988 |
Leads from the MMWR. Childhood chloroquine poisonings--Wisconsin and Washington.
Topics: Brain Diseases; Chloroquine; Diazepam; Drug Therapy, Combination; Epinephrine; Female; Humans; Infan | 1988 |
Clinical pharmacology looks at tropical medicine.
Topics: Amodiaquine; Anthelmintics; Antimalarials; Chloroquine; Diethylcarbamazine; Filariasis; Filaricides; | 1987 |
[Chloroquine-resistant Plasmodium falciparum malaria imported into Italy].
Topics: Adult; Aminoquinolines; Angola; Chloroquine; Drug Resistance; Humans; Italy; Malaria; Male; Travel | 1987 |
Chloroquine and desethylchloroquine concentrations during regular long-term malaria prophylaxis.
Topics: Adult; Chloroquine; Chromatography, High Pressure Liquid; Female; Humans; Malaria; Male | 1987 |
Chloroquine administration in the treatment of malaria with reference to brands, specification and dosage: a survey in north-eastern Tanzania.
Topics: Chloroquine; Drug Administration Schedule; Drug Labeling; Drug Utilization; Humans; Malaria; Tanzani | 1987 |
Reduced efficacy of chemotherapy of Plasmodium chabaudi in T cell-deprived mice.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Lymphocyte Depletion; Malaria; Mice; Mice, Inb | 1987 |
Vivax malaria.
Topics: Acute Disease; Adult; Cambodia; Chloroquine; Emergencies; Emigration and Immigration; Female; Fluid | 1986 |
Observations on early and late post-sporozoite tissue stages in primate malaria. IV. Pre-erythrocytic schizonts and/or hypnozoites of Chesson and North Korean strains of Plasmodium vivax in the chimpanzee.
Topics: Animals; Anopheles; Aotus trivirgatus; Chloroquine; Humans; Kinetics; Liver; Malaria; Pan troglodyte | 1986 |
In vitro inhibition of Plasmodium falciparum by pyrazofurin, an inhibitor of pyrimidine biosynthesis de novo.
Topics: Amides; Chloroquine; Culture Media; Erythrocytes; Humans; Malaria; Male; Middle Aged; Orotate Phosph | 1986 |
Congenital malaria in Scandinavia.
Topics: Adult; Chloroquine; Female; Humans; Infant, Newborn; Malaria; Maternal-Fetal Exchange; Norway; Plasm | 1986 |
[A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon].
Topics: Africa; Amodiaquine; Cameroon; Cerebral Hemorrhage; Chloroquine; Coma; Drug Resistance; Humans; Mala | 1986 |
Polyresistant malaria in Gurkha soldiers returning from Papua New Guinea: treatment and prevention.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Ethnicity; Hong Kong; Humans; Malaria; Male; | 1986 |
Susceptibility of Plasmodium falciparum to chloroquine in Liberia, West Africa: in vitro tests for 24 and 48 hours.
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; In Vitro Techn | 1986 |
[Plasmodium falciparum malaria resistant to chloroquine in 2 Canadian travelers].
Topics: Adult; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Middle Aged; Plasmodium falcipar | 1986 |
Monitoring of chloroquine sensitivity of Plasmodium falciparum in Haiti, 1981-1983.
Topics: Animals; Chloroquine; Drug Resistance; Haiti; Humans; Malaria; Plasmodium falciparum | 1986 |
In vivo efficacy of chloroquine treatment for Plasmodium falciparum in Malawian children under five years of age.
Topics: Administration, Oral; Child, Preschool; Chloroquine; Drug Evaluation; Humans; Malaria; Malawi; Plasm | 1986 |
Adaptation of the Indochina I/CDC strain of Plasmodium falciparum to the squirrel monkey (Saimiri sciureus).
Topics: Animals; Aotus trivirgatus; Cebidae; Chloroquine; Disease Models, Animal; Drug Resistance; Malaria; | 1986 |
Falciparum malaria--210 cases.
Topics: Adolescent; Adult; Child; Chloroquine; Drug Combinations; Female; Humans; India; Malaria; Male; Midd | 1986 |
[Selection of chloroquine-resistant Plasmodium falciparum strains in tourists under chemoprophylaxis].
Topics: Africa; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Prospective | 1986 |
Falciparum malaria highly resistant to chloroquine in Western Kenya. Case report.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Kenya; Malaria; Male; Plasmodium falciparum | 1986 |
Decreased sensitivity to chloroquine and quinine of some Plasmodium falciparum strains from Senegal in September 1984.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria; Plasmod | 1986 |
High level of sensitivity to chloroquine of 72 Plasmodium falciparum isolates from southern Cameroon in January 1985.
Topics: Animals; Antimalarials; Cameroon; Child; Chloroquine; Drug Resistance; Humans; Malaria; Mefloquine; | 1986 |
In vivo response of Plasmodium falciparum to different doses of chloroquine in semi-immune children in Liberia, West Africa.
Topics: Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Humans; Infant; Liberia; Mal | 1986 |
Sensitivity in vivo of Plasmodium falciparum to chloroquine and pyrimethamine/sulfadoxine in a coastal area of Tanzania.
Topics: Adolescent; Child; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Plasmodium falciparum; P | 1986 |
Imported cases of chloroquine-resistant falciparum malaria in Iran.
Topics: Adolescent; Adult; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combina | 1986 |
[Malaria prevention. Risk of infection in relation to preventive measures].
Topics: Adult; Africa; Antimalarials; Chloroquine; Drug Combinations; Female; Germany, West; Humans; India; | 1986 |
Serious problems with antimalarial drugs.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Co | 1986 |
Epidemiology of emergence and spread of drug-resistant falciparum malaria in Southeast Asia.
Topics: Anopheles; Asia, Southeastern; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; I | 1986 |
The efficacy of artemether (qinghaosu) in Plasmodium falciparum and P. vivax in Burma.
Topics: Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Combinations; Humans; Malaria; Plasmodium | 1986 |
[Geographical distribution of chloroquine-resistant strains of malignant malaria in Yunnan Province].
Topics: Adolescent; Child; Child, Preschool; China; Chloroquine; Drug Resistance; Humans; Infant; Malaria; P | 1986 |
[Chloroquine-resistant malignant malaria in Hainan Island: report of 10 years' study].
Topics: China; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Pyrimethamine | 1986 |
Failures of combined chloroquine and Fansidar prophylaxis in American travelers to East Africa.
Topics: Adult; Aged; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Female; Human | 1986 |
[Effect of Dichroa febrifuga L. on chloroquinsensible and chloroquinresistant malaria parasites].
Topics: Animals; Chloroquine; Drug Resistance; Malaria; Medicine, Chinese Traditional; Medicine, East Asian | 1986 |
Health education and community participation in mass drug administration for malaria in Nicaragua.
Topics: Advertising; Antimalarials; Chloroquine; Female; Health Education; History, 20th Century; Humans; Ma | 1986 |
Chloroquine-resistant malaria. A case report.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; | 1986 |
[A Parisian case of congenital malaria].
Topics: Chloroquine; Female; Humans; Infant, Newborn; Malaria; Maternal-Fetal Exchange; Paris; Plasmodium vi | 1986 |
Screening Azadirachta indica and Pisum sativum for possible antimalarial activities.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Fabaceae; Malaria; Male; Mice; Pl | 1986 |
[Preliminary study, in vitro, of the sensitivity of P. falciparum to chloroquine, mefloquine and quinine during 1985, in Kampuchea].
Topics: Adult; Antimalarials; Cambodia; Chloroquine; Humans; Malaria; Mefloquine; Microbial Sensitivity Test | 1986 |
[Experimental studies on the biological characteristics of Plasmodium vivax in south Yunnan].
Topics: Animals; Anopheles; China; Chloroquine; Humans; Malaria; Plasmodium vivax; Primaquine; Recurrence | 1986 |
[The extent of resistance of chloroquine-resistant falciparum malaria and the geographic distribution in China].
Topics: China; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1986 |
Vivax and falciparum malaria seen at an Indian service hospital.
Topics: Adolescent; Adult; Anemia, Pernicious; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Huma | 1986 |
Adult cerebral malaria in Zambia: preliminary report of clinical findings and treatment response.
Topics: Adolescent; Adult; Brain Diseases; Child; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; P | 1986 |
Concentrations of chloroquine and desethylchloroquine in capillary blood dried on filter paper during and after treatment of Tanzanian children infected with Plasmodium falciparum.
Topics: Adolescent; Child; Chloroquine; Chromatography, Liquid; Humans; Kinetics; Malaria; Plasmodium falcip | 1986 |
Compatibility of relapse patterns of Plasmodium cynomolgi infections in rhesus monkeys with continuous cyclical development and hypnozoite concepts of relapse.
Topics: Animals; Chloroquine; Female; Humans; Macaca mulatta; Malaria; Male; Pan troglodytes; Plasmodium; Pl | 1986 |
Concurrent chloroquine- and Fansidar-resistant Plasmodium falciparum: an imported case into Zimbabwe.
Topics: Adult; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria; Male; Plasmodium falciparum | 1986 |
Malarial prophylaxis with chloroquine/proguanil.
Topics: Chloroquine; Humans; Malaria; Papua New Guinea; Plasmodium falciparum; Proguanil | 1987 |
Qinghaosu resistance in rodent malaria.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Malaria; Male; Mice; Plasmodium; | 1986 |
Chloroquine-resistant falciparum malaria in Punjab (northern India)
Topics: Chloroquine; Drug Resistance; Humans; India; Malaria; Plasmodium falciparum | 1986 |
[Drug sensitivity of malaria in Madagascar. Comparison in vivo and in vitro of the effects of chloroquine and amodiaquine on P. falciparum in 1984].
Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Madagascar; | 1986 |
[Drug resistance of Plasmodium falciparum in Congo. I. In vivo study with 10 and 25 mg/kg of chloroquine (235 tests)].
Topics: Child; Child, Preschool; Chloroquine; Congo; Drug Resistance, Microbial; Humans; Infant; Malaria; Pl | 1986 |
Epidemiology of the emergence and spread of drug-resistant falciparum malaria in South-East Asia and Australasia.
Topics: Antimalarials; Asia, Southeastern; Cambodia; Chloroquine; Dapsone; Drug Combinations; Drug Resistanc | 1986 |
Chloroquine-resistant falciparum malaria from East Africa.
Topics: Adult; Africa, Eastern; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance, Microbial | 1986 |
A combination of sulfamonomethoxine and pyrimethamine versus other drugs for the treatment of malaria.
Topics: Adolescent; Adult; Aged; Chloroquine; Drug Combinations; Female; Humans; Malaria; Male; Middle Aged; | 1986 |
Response of falciparum malaria in vivo to a standard regimen of chloroquine in Kisumu District, Western Kenya.
Topics: Blood; Child; Chloroquine; Female; Humans; Kenya; Malaria; Male; Plasmodium falciparum; Time Factors | 1986 |
Clinical and laboratory characterization of a chloroquine-resistant Plasmodium falciparum strain acquired in the Central African Republic.
Topics: Adult; Central African Republic; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Pla | 1987 |
Chloroquine-resistant malaria.
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Mozambique; Plasmodium falciparum; Tanzania | 1987 |
[Treatment of imported tropical malaria caused by chloroquine-resistant strains of P. falciparum].
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium fa | 1987 |
[Ultrastructural study on the effect of pyronaridine on the erythrocytic stages of chloroquine-resistant strain of Plasmodium berghei].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Malaria; Mice; Naphthyridines; P | 1986 |
In vitro susceptibility of chloroquine resistant Plasmodium falciparum to mefloquine in Delhi.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Humans; India; Malar | 1986 |
Effect of P. vivax malaria on G-6-PD pH-optima of host red cells.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Erythrocytes; Female; Glucosephosphate Dehy | 1986 |
Efficacy of malaria prophylaxis in American and Swiss travelers to Kenya.
Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; K | 1987 |
Chloroquine and Fansidar prophylaxis--a reply.
Topics: Chloroquine; Drug Combinations; Erythrocytes; Humans; Malaria; Plasmodium falciparum; Pyrimethamine; | 1987 |
Leads from the MMWR. Chloroquine-resistant Plasmodium falciparum malaria in West Africa.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Middle Aged; Nigeria; Plasmodium fal | 1987 |
Single-dose chloroquine therapy for Plasmodium falciparum in children in Togo, West Africa.
Topics: Administration, Oral; Child, Preschool; Chloroquine; Humans; Infant; Malaria; Plasmodium falciparum; | 1987 |
Plasma and whole blood mefloquine concentrations during treatment of chloroquine-resistant falciparum malaria with the combination mefloquine-sulphadoxine-pyrimethamine.
Topics: Adolescent; Adult; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Intes | 1987 |
The implementation of community participation in the control of malaria in rural Tanjung Pinang, Indonesia.
Topics: Attitude to Health; Chloroquine; Community Participation; Health Education; Humans; Indonesia; Malar | 1986 |
Excretion of chloroquine, dapsone and pyrimethamine in human milk.
Topics: Adult; Chloroquine; Dapsone; Drug Combinations; Female; Humans; Malaria; Milk, Human; Pregnancy; Pyr | 1986 |
Phospholipid organization in monkey erythrocytes upon Plasmodium knowlesi infection.
Topics: Androgen-Binding Protein; Animals; Carrier Proteins; Cell Membrane Permeability; Chloroquine; Erythr | 1987 |
Phagocytic function of monocytes of rhesus monkeys during Plasmodium knowlesi infection and the effect of treatment with chloroquine.
Topics: Animals; Chloroquine; Dose-Response Relationship, Drug; Macaca mulatta; Malaria; Monocytes; Phagocyt | 1986 |
Chloroquine excretion following malaria prophylaxis.
Topics: Adult; Chloroquine; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Malaria; Male | 1987 |
Effect of chloroquine on cellular immune responses of normal and P. knowlesi-infected rhesus monkeys.
Topics: Animals; Chloroquine; Immunity, Cellular; Lymphocyte Activation; Lymphocytes; Macaca mulatta; Malari | 1987 |
Effect of Plasmodium yoelii nigeriensis infection and chloroquine on the hepatic mixed function oxidase system of mice.
Topics: Animals; Chloroquine; Cytochrome P-450 Enzyme System; Malaria; Mice; Microsomes, Liver; Mixed Functi | 1987 |
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Erythrocyte Cou | 1987 |
Functional drug targeting to erythrocytes in vivo using antibody bearing liposomes as drug vehicles.
Topics: Animals; Chloroquine; Cholesterol; Erythrocytes; Gangliosides; Immunoglobulin Fab Fragments; Lipid B | 1987 |
Changes in sources of treatment occurring after inception of a community-based malaria control programme in Saradidi, Kenya.
Topics: Adolescent; Adult; Attitude to Health; Chloroquine; Choice Behavior; Community Health Services; Fema | 1987 |
Usage of community-based chloroquine treatment for malaria in Saradidi, Kenya.
Topics: Adolescent; Adult; Aged; Attitude to Health; Child; Child, Preschool; Chloroquine; Choice Behavior; | 1987 |
Consumption of chloroquine phosphate provided for treatment of malaria by volunteer village health workers in Saradidi, Kenya.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Services; F | 1987 |
Malaria chemoprophylaxis to pregnant women provided by community health workers in Saradidi, Kenya. I. Reasons for non-acceptance.
Topics: Adolescent; Adult; Attitude to Health; Chloroquine; Community Health Services; Fear; Female; Humans; | 1987 |
Drug-induced haemolysis masquerading as blackwater fever.
Topics: Adult; Blackwater Fever; Chloroquine; Diagnosis, Differential; Female; Glucosephosphate Dehydrogenas | 1987 |
[Various recommendations in the prophylaxis of chloroquine-resistant malaria].
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria | 1986 |
Imported malaria: problems with diagnosis and prevention.
Topics: Chloroquine; Disease Reservoirs; Humans; Malaria; Military Personnel; Nebraska; Refugees; Transfusio | 1986 |
[The threat of malaria in the light of current epidemiology].
Topics: Chloroquine; Female; Kenya; Malaria; Male; Switzerland; Travel | 1986 |
Systematic chemotherapy of febrile cases: a substitute strategy for malaria control in rural areas of Africa.
Topics: Burkina Faso; Child, Preschool; Chloroquine; Humans; Infant; Malaria; Patient Compliance | 1986 |
Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine.
Topics: Child, Preschool; Chloroquine; Drug Combinations; Humans; Malaria; Male; Pyrimethamine; Stevens-John | 1986 |
Malaria prophylaxis.
Topics: Antimalarials; Child; Chloroquine; Dapsone; Drug Combinations; Female; Humans; Malaria; Pregnancy; P | 1986 |
Progressive changes in the liver function of monkeys following Plasmodium knowlesi infection.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Chloroquine; Liver; Macaca mu | 1986 |
Acute cerebellar ataxia in adults (report of two cases).
Topics: Acute Disease; Adult; Age Factors; Cerebellar Ataxia; Chloroquine; Humans; Malaria; Male; Prednisolo | 1986 |
[Further studies on the relapse of Plasmodium cynomolgi in rhesus monkeys].
Topics: Animals; Chloroquine; Macaca mulatta; Malaria; Plasmodium; Recurrence | 1986 |
Chemoprophylaxis of malaria.
Topics: Abnormalities, Drug-Induced; Chloroquine; Deafness; Female; Humans; Infant, Newborn; Lupus Erythemat | 1986 |
Lack of effect of antimalarial prophylaxis with chloroquine or amodiaquine in cutaneous leishmaniasis in French Guiana.
Topics: Amodiaquine; Chloroquine; Humans; Leishmaniasis; Malaria | 1986 |
Experiences with malaria chemoprophylaxis.
Topics: Adult; Chloroquine; Humans; Hungary; Malaria; Pyrimethamine; Travel | 1986 |
Evaluation of three qualitative tests for detection of chloroquine in urine--agreement with plasma concentrations determined with liquid chromatography.
Topics: Chloroquine; Chromatography, Liquid; Erythrocytes; Female; Humans; Hydrogen-Ion Concentration; Malar | 1986 |
Chloroquine administration for malaria suppression after abdominal surgery.
Topics: Abdomen; Administration, Oral; Chloroquine; Humans; Injections, Subcutaneous; Malaria; Postoperative | 1987 |
The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 1. Selection, training and practice.
Topics: Adult; Amodiaquine; Attitude to Health; Chloroquine; Community Health Workers; Female; Fever; Humans | 1985 |
The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health.
Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Community Health Workers; Fever; Huma | 1985 |
Leads from the MMWR. Adverse reactions to Fansidar and updated recommendations for its use in the prevention of malaria.
Topics: Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Pyrimethami | 1985 |
Plasmodium vivax malaria in children.
Topics: Chloroquine; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria; Plasmodium vivax; P | 1985 |
[A case of malaria tropicameningoencephalitis (neuromalaria) with chloroquine and pyrimethamine/sulfadoxine resistance].
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Hu | 1985 |
Malaria in pregnancy.
Topics: Adult; Chloroquine; Female; Humans; Malaria; Plasmodium falciparum; Pregnancy; Pregnancy Complicatio | 1985 |
Antimalarial drug susceptibility testing of Plasmodium falciparum in Thailand using a microdilution radioisotope method.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Lethal Dose 50; Mala | 1985 |
Enhancement of the curative activity of primaquine by concomitant administration of mirincamycin.
Topics: Animals; Antimalarials; Chloroquine; Clindamycin; Drug Therapy, Combination; Female; Macaca mulatta; | 1985 |
Chloroquine-resistant falciparum malaria imported into the Netherlands.
Topics: Adult; Chloroquine; Humans; Malaria; Netherlands; Plasmodium falciparum | 1985 |
Serial studies on the evolution of chloroquine resistance in an area of East Africa receiving intermittent malaria chemosuppression.
Topics: Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria; Plasmodium falciparu | 1985 |
Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells.
Topics: Amines; Animals; Cell Line; Chloroquine; Humans; Liver; Lysosomes; Malaria; Plasmodium berghei; Prim | 1985 |
Susceptibility of human malaria parasites to chloroquine is pH dependent.
Topics: Ammonium Chloride; Cells, Cultured; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Humans; M | 1985 |
Plasmodium falciparum infection not responding to chloroquine in Nigeria.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum | 1985 |
Studies of resistance to chloroquine, quinine, amodiaquine and mefloquine among Philippine strains of Plasmodium falciparum.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Mefloquine; Ph | 1985 |
In vivo and in vitro chloroquine-resistant falciparum malaria in Venda. A case report.
Topics: Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium falciparum; Sout | 1985 |
Chloroquine uptake by Plasmodium falciparum-infected human erythrocytes during in vitro culture and its relationship to chloroquine resistance.
Topics: Chloroquine; Drug Resistance, Microbial; Erythrocytes; Humans; In Vitro Techniques; Malaria; Plasmod | 1985 |
[Malaria imported from Tanzania to Algeria. Apropos of a case resistant to chloroquine].
Topics: Adult; Algeria; Animals; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium | 1985 |
The development and ultrastructure of Plasmodium falciparum damaged in vitro by human "crisis" sera and by chloroquine.
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Cytotoxicity, Immunologic; Encephalitis; Erythrocy | 1985 |
[Drug resistance of Plasmodium falciparum in Burundi].
Topics: Adolescent; Animals; Burundi; Child; Chloroquine; Drug Resistance, Microbial; Humans; In Vitro Techn | 1985 |
Response of Plasmodium falciparum to chloroquine in hospital patients at Muheza, Tanzania.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Kenya; Malaria; Mal | 1985 |
[Swedish cases of fatal malaria. Chloroquine-resistant falciparum strains].
Topics: Adolescent; Adult; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Pl | 1985 |
Revised recommendations for preventing malaria in travelers to areas with chloroquine-resistant Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Trav | 1985 |
Sensitivity of Plasmodium falciparum to antimalarial drugs in Colombia.
Topics: Amodiaquine; Antimalarials; Chloroquine; Colombia; Drug Combinations; Drug Resistance, Microbial; Ge | 1985 |
Mefloquine failure in a case of falciparum malaria induced with a multidrug-resistant isolate in a non-immune subject.
Topics: Adult; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Mefloquine; Ph | 1985 |
[The clinician, the microscopist and drug-resistant hematozoa].
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum | 1985 |
Chloroquine-resistant malaria from Bombay.
Topics: Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; India; Malaria; Male; Plas | 1985 |
Recent trends in the importation of malaria caused by Plasmodium falciparum into the United States from Africa.
Topics: Africa, Eastern; Africa, Western; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falcipar | 1985 |
Malaria in Vanuatu.
Topics: Australia; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium vivax | 1985 |
Pregnancy-induced recrudescences strengthen malarial immunity in mice infected with Plasmodium berghei.
Topics: Adrenal Cortex Hormones; Animals; Antilymphocyte Serum; Chloroquine; Female; Immune Tolerance; Immun | 1985 |
Chloroquine-resistant falciparum malaria imported into Spain from Malawi.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malawi; Male; Middle Aged; Plasmodium falc | 1985 |
Chloroquine-resistant falciparum malaria in northern Malawi.
Topics: Adult; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; Malawi; Male; Mi | 1985 |
A study of the uptake of chloroquine in malaria-infected erythrocytes. High and low affinity uptake and the influence of glucose and its analogues.
Topics: 3-O-Methylglucose; Animals; Binding Sites; Chloroquine; Deoxyglucose; Erythrocytes; Glucose; Lactate | 1985 |
Acute malaria prolongs susceptibility of mice to Plasmodium berghei sporozoite infection.
Topics: Animals; Antibody Formation; Chloroquine; Female; Host-Parasite Interactions; Immune Tolerance; Mala | 1985 |
Chloroquine-resistant Plasmodium falciparum malaria in South Africa. A case report.
Topics: Adolescent; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans; Mala | 1985 |
The action of salinomycin-Na and lasalocid-Na on chloroquine- and mepacrine-resistant line of Plasmodium berghei K 173-strain in Wistar rats.
Topics: Animals; Anti-Bacterial Agents; Cell Membrane; Chloroquine; Cytoplasm; Drug Resistance, Microbial; L | 1985 |
[The combined use of artemether, sulfadoxine, pyrimethamine and primaquine in the treatment of chloroquine-resistant falciparum malaria].
Topics: Adult; Animals; Antimalarials; Artemether; Artemisinins; Child; Chloroquine; Drug Resistance, Microb | 1985 |
[A successive survey on the sensitivity of P. falciparum patients to chloroquine by in vitro microtechnic and in vivo test on Hainan Island].
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; China; Chloroquine; Drug Resistance, Microbial; | 1985 |
In vitro chloroquine-resistant Plasmodium falciparum malaria in the Natal/Kwazulu area.
Topics: Adult; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Ma | 1985 |
Malaria prophylaxis for Canadian travellers.
Topics: Amodiaquine; Canada; Chloroquine; Dapsone; Doxycycline; Drug Combinations; Drug Resistance, Microbia | 1985 |
Effects of chloroquine on the serum complement system.
Topics: Adult; Antigen-Antibody Complex; Chloroquine; Complement Activation; Complement C3; Complement Facto | 1985 |
Antimalarial agents. 1. alpha-Santonin-derived cyclic peroxide as potential antimalarial agent.
Topics: Animals; Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance; Malaria; Mice; Plasmodium berg | 1985 |
[In vivo response to chloroquine during the treatment of Plasmodium falciparum malaria in a suburban region of Kinshasa, Zaire].
Topics: Child; Child, Preschool; Chloroquine; Democratic Republic of the Congo; Drug Resistance, Microbial; | 1985 |
Chloroquine induces oxidative lysis of Plasmodium berghei parasitized red blood cells.
Topics: Animals; Chloroquine; Erythrocytes; Hemolysis; Malaria; Mice; Plasmodium berghei | 1985 |
Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs.
Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; I | 1985 |
[8 cases of drug-resistant Plasmodium falciparum malaria contracted in Mozambique].
Topics: Adult; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Male; Mefloquine; Mozambique; P | 1985 |
In vivo and in vitro assessment of the sensitivity of Plasmodium falciparum to chloroquine in four districts of Tanga region, Tanzania.
Topics: Child; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Microbial Sensitivity Tests; Plasmo | 1985 |
In vivo assessment of the sensitivity of Plasmodium falciparum to sulphadoxine/pyrimethamine combination (Fansidar) in six localities in Tanzania where chloroquine-resistant P. falciparum has been detected.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance, | 1985 |
Susceptibility of Plasmodium falciparum in The Gambia to pyrimethamine, Maloprim and chloroquine.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Dose-Response Relationship, Drug; Drug | 1985 |
Preliminary study of the response of Plasmodium falciparum to chloroquine in Sistan and Baluchestan province of Iran.
Topics: Chloroquine; Humans; Iran; Malaria; Microbial Sensitivity Tests; Plasmodium falciparum | 1985 |
[In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of 2 years' study].
Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Human | 1985 |
Failure of large-dose erythromycin in combination with a standard dose of chloroquine or quinine in the treatment of human falciparum malaria.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Erythromycin; Humans; Mal | 1985 |
Herpes zoster in children following malaria.
Topics: Child; Child, Preschool; Chloroquine; Female; Herpes Zoster; Humans; Immune Tolerance; Immunity, Cel | 1985 |
[Preliminary use of delimiting the boundry of endemic foci and eliminating their source in the prevention and treatment of malaria].
Topics: China; Chloroquine; Disease Reservoirs; Humans; Malaria; Plasmodium vivax; Primaquine; Retrospective | 1985 |
[Development of a piperaquine-resistant line of Plasmodium berghei K 173 strain].
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Malaria; Male; Meflo | 1985 |
Drug-resistant malaria--changing patterns mean difficult decisions.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans | 1985 |
In vitro assessment of sensitivity of Plasmodium falciparum to chloroquine and mefloquine in Ghana.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Ghana; Humans; Malar | 1985 |
[Malaria chemoprophylaxis. Resistance problems].
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Mi | 1985 |
Susceptibility of Plasmodium falciparum to chloroquine in northern Liberia after 20 years of chemosuppression and therapy.
Topics: Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Liberia; Malaria; | 1985 |
Mass drug administration in Andhra Pradesh in areas under Plasmodium falciparum containment programme.
Topics: Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium falciparum; Primaquine; R | 1985 |
[Drug resistance in malaria, what to do? Apropos of 3 cases].
Topics: Adult; Africa, Eastern; Chloroquine; Drug Resistance, Microbial; French Guiana; Humans; Malaria; Mal | 1985 |
[The sensitivity of Plasmodium falciparum to chloroquine in South Henan].
Topics: Adolescent; Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum | 1985 |
Adverse reactions to Fansidar and updated recommendations for its use in the prevention of malaria.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria; Plasmodium falcipar | 1985 |
Chloroquine resistant falciparum malaria acquired in South Africa.
Topics: Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium falciparum; Sout | 1985 |
Safety of chloroquine in chemosuppression of malaria during pregnancy.
Topics: Abnormalities, Drug-Induced; Chloroquine; Female; Humans; Infant, Newborn; Malaria; Male; Pregnancy; | 1985 |
Mixed malarial infection due to Plasmodium falciparum and P vivax.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum; Plasmo | 1985 |
Fansidar in malaria prophylaxis.
Topics: Antimalarials; Chloroquine; Drug Combinations; Humans; Malaria; Pyrimethamine; Sulfadoxine; Sulfanil | 1985 |
Recent trends of chemotherapy and vaccination against malaria: new lamps for old.
Topics: Antibodies, Monoclonal; Chloroquine; Drug Resistance, Microbial; Global Health; Humans; Immunotherap | 1985 |
Excess release of ferriheme in G6PD-deficient erythrocytes: possible cause of hemolysis and resistance to malaria.
Topics: Chloroquine; Erythrocyte Membrane; Ferric Compounds; Glucosephosphate Dehydrogenase Deficiency; Heme | 1986 |
Cases from the aerospace medicine residents' teaching files. Case #11. New left bundle block on screening exam.
Topics: Aerospace Medicine; Antimalarials; Bundle-Branch Block; Chloroquine; Electrocardiography; Humans; Ma | 1986 |
Malaria prophylaxis for travellers.
Topics: Chloroquine; Humans; Malaria; Travel | 1985 |
Chloroquine kinetics in normal and P. knowlesi infected rhesus monkeys.
Topics: Animals; Chloroquine; Half-Life; Kinetics; Macaca mulatta; Malaria | 1985 |
Shaking chills and fever.
Topics: Adult; Antimalarials; Chloroquine; Humans; Malaria; Male; Plasmodium; Primaquine | 1985 |
[Tactics and strategy of malaria control].
Topics: Animals; Anopheles; Chloroquine; Developing Countries; Female; Humans; Malaria; Mosquito Control; Qu | 1985 |
[Malaria in 1985: new recommendations].
Topics: Africa; Asia; Chloroquine; Drug Combinations; Humans; Malaria; Pyrimethamine; South America; Sulfado | 1985 |
[Therapeutic effect of pyronaridine given intragastrically on Plasmodium cynomolgi-infected rhesus monkeys].
Topics: Animals; Antimalarials; Chloroquine; Macaca fascicularis; Macaca mulatta; Malaria; Naphthyridines; R | 1985 |
[Lipoproteins and malaria. I. Immunogenicity of serum lipoproteins in mice infected with Plasmodium chabaudi].
Topics: Animals; Antigen-Antibody Complex; Autoantibodies; Chloroquine; Female; Immunoglobulin G; Lipoprotei | 1985 |
Factors affecting the compliance of malaria chemosuppression with chloroquine at some maternal and child health clinics in Tanga Region, Tanzania.
Topics: Adolescent; Adult; Child, Preschool; Chloroquine; Female; Humans; Infant; Infant, Newborn; Malaria; | 1985 |
A comparison of chloroquine and pyrimethamine as malaria chemoprophylactics in young Nigerian children.
Topics: Antibodies; Chloroquine; Enzyme-Linked Immunosorbent Assay; Ferritins; Folic Acid; Hemodynamics; Hum | 1985 |
Loading dose in antimalarial prophylaxis.
Topics: Chloroquine; Humans; Malaria | 1985 |
Chloroquine dosage for prevention of malaria mortality and the use of primaquine to slow down the spread of resistance.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Primaquine | 1985 |
[Remarks on the drug prevention of malaria].
Topics: Adult; Antimalarials; Child; Chloroquine; Drug Administration Schedule; Drug Combinations; Drug Resi | 1985 |
Induced malaria in narcotic addicts.
Topics: Adult; Animals; Anopheles; California; Chloroquine; Disease Reservoirs; Disease Vectors; Heroin; Hum | 1971 |
Fibrin-degradation products in cerebral malaria.
Topics: Adolescent; Adult; Blood Coagulation Tests; Blood Platelets; Cerebrovascular Disorders; Child, Presc | 1972 |
Ancrod, heparin, and -aminocaproic acid in simian Knowlesi malaria.
Topics: Aminocaproates; Animals; Anticoagulants; Blood Coagulation Disorders; Chloroquine; Fibrinolytic Agen | 1972 |
Chloroquine-resistant falciparum malaria in Thailand.
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Malari | 1965 |
Resistance to chloroquine.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Thailand | 1965 |
125-I-labelled fibrinogen in cerebral malaria.
Topics: Adolescent; Adult; Blood Coagulation; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Fibri | 1966 |
Sulphormethoxine in chloroquine-resistant falciparum malaria in Thailand.
Topics: Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Plasmodium falciparum; Sulfo | 1967 |
Peritoneal dialysis in acute renal failure following malaria.
Topics: Acute Kidney Injury; Adult; Bicarbonates; Chloroquine; Folic Acid; Humans; Hydrocortisone; Malaria; | 1967 |
Chloroquine in the salt.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Pesticides; Sodium Chloride | 1967 |
Morphological changes in lasmodium vivax in patients under treatment with chloroquine.
Topics: Cell Nucleus; Chloroquine; Cytoplasm; Drug Resistance, Microbial; Humans; Malaria; Plasmodium vivax; | 1968 |
Choroquine-resistant Plasmodium falciparum malaria in the United Kingdom.
Topics: Adult; Chloroquine; England; Humans; Malaria; Malaysia; Male; Penicillin Resistance; Penicillins; Pl | 1968 |
Chloroquine-resistant falciparum malaria.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malaysia; Male; Plasmodium falcipar | 1968 |
Drug-resistant malaria.
Topics: Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Primaquine | 1969 |
Drug-resistant malaria.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax | 1969 |
Prophylaxis of malaria in man using the sulfone DFD with pyrimethamine.
Topics: Chloroquine; Dapsone; Formaldehyde; Humans; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; | 1973 |
Experience with mixed infections of Plasmodium falciparum and vivax.
Topics: Antimalarials; Chloroquine; Dapsone; Humans; Malaria; Military Medicine; Plasmodium falciparum; Plas | 1973 |
Activity and some properties of an acid proteinase from normal and Plasmodium berghei-infected red cells.
Topics: Acid Phosphatase; Animals; Cell-Free System; Chloroquine; Dithiothreitol; Edetic Acid; Erythrocytes; | 1973 |
Response to treatment in man of multi-drug resistant Plasmodium falciparum from Panama.
Topics: Adult; Amodiaquine; Animals; Anopheles; Antimalarials; Chloroquine; Drug Resistance, Microbial; Drug | 1974 |
Infections with Plasmodium falciparum and Plasmodium vivax in the owl monkey--model systems for basic biological and chemotherapeutic studies.
Topics: Animal Feed; Animals; Butylamines; Chlorobenzenes; Chloroquine; Colombia; Darkness; Disease Models, | 1973 |
Plasmodium cynomolgi: influence of x-irradiation and sporozoite dilution on relapse patterns in infected rhesus monkeys.
Topics: Animals; Anopheles; Blood; Chloroquine; Haplorhini; Injections, Intramuscular; Macaca; Malaria; Plas | 1974 |
Accidental human infection with Plasmodium cynomolgi bastianellii.
Topics: Adult; Animals; Anopheles; Chloroquine; Environmental Exposure; Female; Haplorhini; Humans; Insect V | 1973 |
Activity of two chlorinated lincomycin analogues against chloroquine-resistant falciparum malaria in owl monkeys.
Topics: Animals; Chlorine; Chloroquine; Drug Resistance; Haplorhini; Lincomycin; Malaria; Plasmodium falcipa | 1972 |
[Prevention and treatment of malaria. 1. Analysis of 73 cases of malaria in Japan].
Topics: Adult; Chloroquine; Humans; Japan; Malaria; Middle Aged; Primaquine; Quinine | 1973 |
Improved therapy for Vietnam acquired vivax malaria.
Topics: Chloroquine; Drug Therapy, Combination; Humans; Malaria; Male; Military Medicine; Plasmodium vivax; | 1974 |
Resistance to antimalarials.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Pyrimethamine | 1966 |
Chloroquine-resistant Falciparum malaria in a semi-immune indigenous population in North Malaya.
Topics: Adolescent; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Malaysia; Male | 1966 |
Coombs'-positive hemolytic disease in malaria.
Topics: Adrenal Cortex Hormones; Adult; Anemia, Hemolytic; Antibodies; Chloroquine; Coombs Test; Drug Erupti | 1968 |
The control of malaria among the Orang Asli in West Malaysia.
Topics: Adolescent; Adult; Aged; Asian People; Black People; Child; Child, Preschool; Chloroquine; Ethnicity | 1972 |
Characterization of a drug resistant strain of Plasmodium falciparum from Burma.
Topics: Adult; Amodiaquine; Anopheles; Chloroquine; Drug Resistance, Microbial; Human Experimentation; Human | 1973 |
Generalised pustular drug rash.
Topics: Adult; Aged; Biguanides; Chloramphenicol; Chloroquine; Cross Reactions; Digoxin; Drug Eruptions; Fur | 1973 |
Cytochrome oxidase activity in a normal and some drug-resistant strains of Plasmodium berghei--a cytochemical study. I. Asexual erythrocytic stages.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Electron Transport Complex IV; Erythrocytes; Histo | 1969 |
Pathologic physiology and chemotherapy of Plasmodium berghei. IX. Gastric secretion and the influence of 1-aminocyclopentane carboxylic acid (WR 14, 997 or cycloleucine).
Topics: Amino Acids; Animals; Anorexia Nervosa; Antimalarials; Chloroquine; Chlorphentermine; Cyclopentanes; | 1969 |
Entero-Vioform and organic neurologic disease.
Topics: Arthritis, Rheumatoid; Chloroquine; Clioquinol; Diarrhea; Humans; Malaria; Optic Atrophy; Peripheral | 1971 |
Plasmodium hylobati: a malaria parasite of the gibbon.
Topics: Animals; Anopheles; Cell Nucleus; Chloroquine; Erythrocytes, Abnormal; Hominidae; Inclusion Bodies; | 1972 |
Nonlinear response of the reticuloendothelial system upon stimulation.
Topics: Animals; Avian Sarcoma Viruses; Bacterial Infections; Chickens; Chloroquine; Dose-Response Relations | 1972 |
The chemotherapy of rodent malaria. XX. Autophagic vacuole formation in Plasmodium berghei in vitro.
Topics: Animals; Anti-Bacterial Agents; Chloroquine; Cycloheximide; Dactinomycin; Dose-Response Relationship | 1974 |
Effects of diaphenylsulphone (dapsone) against Plasmodium vivax of South West Pacific origin.
Topics: Adult; Child; Chloroquine; Culicidae; Dapsone; Drug Resistance, Microbial; Humans; Insect Vectors; M | 1968 |
The biology of rodent malaria with particular reference to Plasmodium vinckei vinckei Rodhain 1952.
Topics: Aminobenzoates; Animals; Apicomplexa; Chloroquine; Congo; Cricetinae; Culicidae; Diet Therapy; Disea | 1971 |
Letter: Disappointing results in Malaysia with the "Dill Glazko" eosin colour tests for chloroquine in urine.
Topics: Chloroquine; Coloring Agents; False Negative Reactions; False Positive Reactions; Humans; Malaria; M | 1974 |
Forty years of malaria control in Natal and Zululand.
Topics: Animals; Anopheles; Chloroquine; DDT; Disease Outbreaks; Emigration and Immigration; Health Educatio | 1974 |
Malaria prophylactic drug trial in Western Nigeria.
Topics: Child; Chloroquine; Drug Evaluation; Humans; Malaria; Nigeria; Pyrimethamine | 1974 |
Mass drug administration as a supplementary attack measure in malaria eradication programme.
Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Combinations; Humans; Indian Oce | 1974 |
[Prevention of malaria].
Topics: Antimalarials; Chloroquine; Humans; Malaria; Proguanil; Pyrimethamine; World Health Organization | 1974 |
[Malaria in Denmark. Admissions to Blegdam hospital during 1960-73].
Topics: Adolescent; Adult; Child; Chloroquine; Denmark; Female; Hospitalization; Humans; Kinins; Malaria; Ma | 1974 |
[The effects of chloroquine on mice infected with Plasmodium berghei (malaria)].
Topics: Chloroquine; Malaria | 1972 |
Plasmodium falciparum malaria in Panama resistant to 4-aminoquinoline drugs.
Topics: Amodiaquine; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Panama; Plasmodium falciparum | 1972 |
Evaluation of an in vitro technique for detecting chloroquine resistant falciparum malaria in Thailand.
Topics: Adolescent; Adult; Aged; Animals; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; | 1972 |
Lysosomes, pH and the anti-malarial action of chloroquine.
Topics: Animals; Chloroquine; Cycloheximide; Drug Resistance, Microbial; Erythrocytes; Hydrogen-Ion Concentr | 1972 |
The chemoprophylactic use of diformyl diaminodiphenyl sulfone (DFD) in falciparum malaria.
Topics: Adult; Anopheles; Antimalarials; Blood Cell Count; Chloroquine; Dapsone; Drug Resistance, Microbial; | 1972 |
Malaria--again a diagnostic consideration.
Topics: Chloroquine; Diagnosis, Differential; Erythrocytes; Humans; Malaria; Plasmodium falciparum; Plasmodi | 1972 |
Malaria.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Fluorescent Antibody Technique; Humans; Immu | 1972 |
Effect of four different types of single-dose treatment with chloroquine and with chloroquine and pyrimethamine on Plasmodium falciparum infections in a semi-immune population in northern Nigeria.
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Drug Combinations; Humans; Infant; Malaria; Nigeri | 1972 |
Preliminary studies on a Philippine strain of Plasmodium falciparum resistant to amodiaquine.
Topics: Adult; Amodiaquine; Body Weight; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Phi | 1972 |
Response of drug-resistant Plasmodium falciparum to combined therapy in Panama.
Topics: Adult; Amodiaquine; Child; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Malaria; Panama; | 1972 |
Sulphadoxine and pyrimethamine as treatment for acute Plasmodium falciparum malaria.
Topics: Acute Disease; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Military Medicine; Pl | 1972 |
In vivo and in vitro studies of chloroquine-resistant malaria in West Malaysia.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malaysia; Microbial Sensitivity Tests; Pla | 1972 |
Discussion of contemporary malaria research needs as reflected in the symposium.
Topics: Animals; Anopheles; Chloroquine; DDT; Drug Resistance, Microbial; Humans; Insect Vectors; Malaria; M | 1972 |
[Plasmodium vivax malaria. Report of a post-prophylactic primary attack with a long latent period].
Topics: Adult; Chloroquine; Denmark; Humans; Malaria; Male; Plasmodium vivax; Time Factors | 1972 |
Effects of minocycline against chloroquine-resistant falciparum malaria.
Topics: Anopheles; Chloroquine; Drug Resistance; Erythrocytes; Humans; Malaria; Male; Minocycline; Plasmodiu | 1972 |
Transfusion-induced malaria. Plasmodium vivax in a 5-month-old child.
Topics: Chloroquine; Fever; Hemolysis; Hepatomegaly; Humans; Infant; Malaria; Male; Plasmodium vivax; Primaq | 1973 |
Mechanism of plasmodial drug resistance.
Topics: Aedes; Animals; Antimalarials; Biodegradation, Environmental; Chemical Phenomena; Chemistry; Chicken | 1972 |
Treatment of malaria.
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax | 1973 |
Imported malaria in Cape Town.
Topics: Chloroquine; Humans; Malaria; Malawi; Plasmodium vivax | 1973 |
Experience with mass drug administration as a supplementary attack measure in areas of vivax malaria.
Topics: Anopheles; Chloroquine; DDT; Emergencies; Humans; Insecticide Resistance; Malaria; Mosquito Control; | 1972 |
Malaria.
Topics: Adult; Animals; Antigen-Antibody Complex; Chloroquine; Disease Vectors; Female; Humans; Malaria; Pla | 1973 |
[Congenital malaria].
Topics: Bone Marrow Examination; Chloroquine; Diagnostic Errors; Female; Humans; Infant; Infant, Newborn; In | 1973 |
Studies of the neutropenia of acute malaria.
Topics: Adult; Agranulocytosis; Bone Marrow Cells; Bone Marrow Examination; Chloroquine; Humans; Isofluropha | 1973 |
Some haematological and biochemical effects of a malaria control programme in New Guinea.
Topics: Adolescent; Adult; Antimalarials; Blood Group Antigens; Blood Proteins; Child; Child, Preschool; Chl | 1973 |
Relapses of vivax malaria after a conventional course of primaquine and chloroquine: report of 2 cases.
Topics: Adult; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Glucosephosphate Dehydrogenase; | 1973 |
Ferrokinetics in patients with malaria: normoblasts and iron incorporation in vitro.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Cell Count; Cells, Cultured; Chloroquine; Erythro | 1973 |
The chemotherapy of rodent malaria. XVII. Dynamics of drug resistance. 3. Influence of drug combinations on the development of resistance to chloroquine in P. berghei.
Topics: Animals; Chloroquine; Drug Interactions; Drug Resistance, Microbial; Malaria; Mice; Plasmodium bergh | 1973 |
The Malumfashi pilot survey. I. Introduction, malaria and urinary schistosomiasis.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Malaria; Ma | 1973 |
Delayed attacks of malaria in visitors to the tropics.
Topics: Adolescent; Adult; Afghanistan; Chloroquine; Female; Humans; India; Iran; Iraq; Malaria; Male; Pakis | 1973 |
Posttransfusion malaria in a newborn.
Topics: Anemia; Antigens; Blood Donors; Chloroquine; Exchange Transfusion, Whole Blood; Female; Fluorescent | 1973 |
Malaria in the Australian army in South Vietnam: successful use of a proguanil-dapsone combination for chemoprophylaxis of chloroquine-resistant falciparum malaria.
Topics: Australia; Chloroquine; Dapsone; Disease Outbreaks; Drug Resistance, Microbial; Humans; Malaria; Mil | 1973 |
[The erythrogram in treated and untreated malaria patients in Western Africa].
Topics: Adolescent; Adult; Chloroquine; Erythrocyte Count; Erythrocytes; Female; Humans; Hydrochloric Acid; | 1973 |
Characterisation of a drug resistant strain of Plasmodium falciparum from Sabah.
Topics: Adult; Amodiaquine; Borneo; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodi | 1973 |
Parasite counts in infections with Plasmodium falciparum.
Topics: Animals; Blood; Chickens; Chloroquine; Erythrocytes; Humans; Leukocyte Count; Malaria; Plasmodium fa | 1973 |
Experimental infection in man with Plasmodium malariae.
Topics: Adult; Animals; Anopheles; Chloroquine; Disease Vectors; Humans; Informed Consent; Injections, Intra | 1973 |
Five day primaquine therapy--an evaluation of radical curative activity against vivax malaria infection.
Topics: Chloroquine; Evaluation Studies as Topic; Humans; India; Malaria; Male; Pakistan; Plasmodium vivax; | 1973 |
Malaria associated with pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Chloroquine; Female; Humans; Malaria; Plasmodium falciparum; Pre | 1973 |
Letter: Delayed attacks of malaria in visitors to the tropics.
Topics: Chloroquine; Humans; Malaria; Plasmodium vivax; Travel | 1973 |
The suppression of Plasmodium falciparum and Plasmodium vivax parasitaemias by a dapsone-pyrimethamine combination.
Topics: Adolescent; Adult; Child; Chloroquine; Dapsone; Drug Combinations; Female; Hematocrit; Humans; Malar | 1973 |
Chloroquine-resistant Falciparum malaria acquired in Vietnam.
Topics: Acute Kidney Injury; Adolescent; Adult; Blood Cell Count; Chloroquine; Dapsone; Drug Resistance, Mic | 1973 |
The evaluation of the presumptive and radical treatments against falciparum malaria in Thailand.
Topics: Adolescent; Adult; Blood; Chloroquine; Drug Evaluation; Female; Humans; Malaria; Male; Plasmodium fa | 1973 |
Malaria in New York City. IV. 1960-1971.
Topics: Adolescent; Adult; Africa, Western; Age Factors; Amodiaquine; Child; Child, Preschool; Chloroquine; | 1974 |
Characteristics of Plasmodium falciparum from the Solomon Islands.
Topics: Anopheles; Blood; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Pacific Islands; Plasmod | 1974 |
The chemotherapy and prophylaxis of malaria.
Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Fe | 1973 |
Two lines of P. berghei berghei resistant to a phenanthrene methanol.
Topics: Binding Sites; Chloroquine; Drug Resistance, Microbial; Malaria; Phenanthrenes; Plasmodium berghei | 1973 |
Letter: Quinine and chloroquine antagonism in falciparum malaria.
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum; Quinine | 1973 |
Letter: A case of neonatal malaria.
Topics: Blood Transfusion; Chloroquine; Female; Fetomaternal Transfusion; Humans; Infant, Newborn; Infant, N | 1972 |
Multidrug-resistant strain of Plasmodium falciparum from eastern Colombia.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Colombia; Drug Combinations; Drug Resistance, Microbi | 1974 |
[Cases of malaria in Sweden].
Topics: Adult; Child, Preschool; Chloroquine; Female; Humans; Malaria; Male; Medical History Taking; Middle | 1973 |
Letter: Transplacental malaria transmisson.
Topics: Chloroquine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Malaria; Male; Maternal-Fet | 1974 |
[The treatment of Plasmodium falciparum malaria in the region of Bobo-Dioulasso, Upper Volta].
Topics: Adolescent; Adult; Burkina Faso; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Malar | 1973 |
Chemotherapeutic activity of combination doses of chloroquine, pyrimethamine, and sulfamethoxy-diazine, a long-acting sulfanilamide, against Plasmodium berghei infections in mice.
Topics: Animals; Chloroquine; Drug Combinations; Malaria; Mice; Plasmodium berghei; Pyrimethamine; Sulfanila | 1973 |
A survey of imported malaria in Western Australia including four cases of drug resistance.
Topics: Adolescent; Adult; Australia; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Emigration an | 1974 |
A comparison between the quinine and chloroquine regimens for falciparum malaria in Vietnam.
Topics: Administration, Oral; Chloroquine; Dapsone; Humans; Injections, Intravenous; Malaria; Male; Military | 1974 |
High-affinity accumulation of chloroquine by mouse erythrocytes infected with Plasmodium berghei.
Topics: Acetates; Alanine; Animals; Binding, Competitive; Chloroquine; Drug Resistance, Microbial; Erythrocy | 1974 |
The chemotherapy of rodent malaria, XIX. The action of a tetracycline derivative, minocycline, on drug-resistant Plasmodium berghei.
Topics: Animals; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Malaria; Mice; Minocycline; Pla | 1974 |
Recent experiences with severe and cerebral malaria.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Brain Diseases; Child; Child, Preschool; Chloroquine; Co | 1974 |
Binding to deoxyribonucleic acid and inhibition of ribonucleic acid polymerase by analogs of chloroquine.
Topics: Animals; Cattle; Chickens; Chloroquine; DNA; DNA-Directed RNA Polymerases; Escherichia coli; Magneti | 1974 |
Chemoprophylaxis of malaria for travelers.
Topics: Africa; Antimalarials; Asia; Central America; Chloroquine; Dapsone; Drug Resistance, Microbial; Drug | 1974 |
Chemotherapy of rodent malaria: transfer of resistance vs mutation.
Topics: Animals; Blood; Cell Division; Chloroquine; Cricetinae; Drug Resistance, Microbial; Erythrocytes; Ex | 1974 |
Suspected chloroquine-resistant P. falciparum in Indonesia: A case report.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Indonesia; Malaria; Plasmodium falci | 1974 |
Some pharmacological aspects of antimalarial drugs.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falcipa | 1974 |
Chloroquine tolerance of Ethiopian strains of P. falciparum.
Topics: Adolescent; Adult; Blood; Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Dr | 1974 |
Imported infections. Unexplained fever.
Topics: Africa; Asia; Brucellosis; Chloramphenicol; Chloroquine; Fever; Humans; Leishmaniasis, Visceral; Liv | 1974 |
Preliminary report of in vitro and in vivo studies on Falciparum malaria in Thailand.
Topics: Animals; Chloroquine; Humans; In Vitro Techniques; Malaria; Plasmodium falciparum; Thailand | 1974 |
Effects of chloroquine upon the maturation of asexual erythrocytic forms of Plasmodium vivax in vitro.
Topics: Animals; Blood; Chloroquine; Humans; In Vitro Techniques; Malaria; Male; Methods; Plasmodium vivax | 1974 |
[Cerebral tropical malaria with blackwater fever. A current diagnostic and therapeutic problem].
Topics: Acute Kidney Injury; Adult; Blackwater Fever; Brain Diseases; Chloroquine; Disseminated Intravascula | 1974 |
[Treatment of drug-resistant malaria: animal experiments].
Topics: Amodiaquine; Animals; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Comb | 1974 |
Transfusion malaria.
Topics: Africa; Blood; Blood Donors; Chloroquine; Epidemiologic Methods; Fluorescent Antibody Technique; Hum | 1974 |
Antimalarian precautions for scandinavian tourists.
Topics: Antimalarials; Chloroquine; Gambia; Humans; Malaria; Plasmodium falciparum; Plasmodium malariae; Pla | 1974 |
Acute falciparum malaria. Complications and treatment.
Topics: Acute Kidney Injury; Brain Diseases; Chloroquine; Coma; Disseminated Intravascular Coagulation; Hepa | 1974 |
Experiences with malaria in the early phase of Australian army involvement in South Vietnam.
Topics: Administration, Oral; Australia; Chloroquine; Humans; Injections, Intravenous; Malaria; Male; Milita | 1974 |
[Imported malaria. Analysis of 27 cases].
Topics: Antimalarials; Body Temperature; Chloroquine; Denmark; Female; Humans; Malaria; Male; Plasmodium viv | 1974 |
Recrudescence, poor response or resistance to quinine of falciparum malaria in Thailand.
Topics: Administration, Oral; Adult; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Inj | 1974 |
Preliminary survey for chloroquine resistant malaria in parts of North Sumatra, Indonesia.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Indones | 1974 |
[Malaria prevention for Swedish tourists in West-Africa].
Topics: Africa, Western; Antimalarials; Biguanides; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodiu | 1974 |
[Vaccination centers give insufficient information].
Topics: Africa, Western; Antimalarials; Chloroquine; Humans; Malaria; Plasmodium; Plasmodium falciparum; Pla | 1974 |
Prevention of drug resistance in rodent malaria by the use of drug mixtures.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Malaria; Mice; Microbia | 1974 |
[Falciparum malaria in childhood (author's transl)].
Topics: Child; Chloroquine; Erythrocytes; Germany; Humans; Malaria; Male; Plasmodium falciparum; Tanzania | 1974 |
Hereditary elliptocytosis and Plasmodium falciparum malaria.
Topics: Adolescent; Chloroquine; Elliptocytosis, Hereditary; Erythrocyte Count; Erythrocytes, Abnormal; Hema | 1972 |
Treatment and complications of vivax malaria in Vietnam.
Topics: Anemia; Chloroquine; Humans; Malaria; Military Medicine; Plasmodium vivax; Primaquine; United States | 1972 |
Studies on the characterization of plasmodium vivax strains from Central America.
Topics: Animals; Central America; Chloroquine; Haplorhini; Humans; Lincomycin; Malaria; Plasmodium vivax; Pr | 1972 |
Protective heterologous immunity between Plasmodium atheruri and other Plasmodium spp. and Babesia spp. in mice.
Topics: Animals; Apicomplexa; Babesiosis; Chloroquine; Cross Reactions; Erythrocytes; Female; Malaria; Mice; | 1972 |
Plasmodium cynomolgi malaria: accidental human infection.
Topics: Adult; Animals; Chloroquine; Haplorhini; Humans; Laboratory Infection; Macaca; Malaria; Male; Monkey | 1973 |
Chloroquine as a malarial suppressive: absence of visual effects.
Topics: Administration, Oral; Adult; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Military Medic | 1973 |
[Chloroquin-resistant tropical malaria in South Surinam].
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Suriname | 1973 |
[Neuromyopathy due to chloroquine. A "pure" case].
Topics: Chloroquine; Electrocardiography; Emaciation; Eye Manifestations; Heart Block; Humans; Malaria; Male | 1973 |
Maternal anaemia and fetal birthweight.
Topics: Anemia; Anemia, Sickle Cell; Birth Weight; Blood Transfusion; Body Height; Chloroquine; Embryonic an | 1973 |
Spontaneous rupture of the pathological spleen in malaria.
Topics: Acute Disease; Adult; Chloroquine; Female; Humans; Malaria; Rupture, Spontaneous; Splenectomy; Splen | 1973 |
Letter: Delayed attacks of malaria in visitors to the tropics.
Topics: Chloroquine; Humans; Malaria; Pyrimethamine; Time Factors; Travel; Tropical Climate | 1973 |
[Letter: Primary long latency in malaria].
Topics: Chloroquine; Malaria; Primaquine; Recurrence; Time Factors | 1973 |
Immunity to exoerythrocytic forms of malaria. I. Course of infection of Plasmodium fallax in turkeys.
Topics: Animals; Blood; Body Weight; Brain; Cells, Cultured; Chick Embryo; Chloroquine; Culture Media; Disea | 1973 |
Immunity to exoerythrocytic forms of malaria. II. Passive transfer of immunity to exoerythrocytic forms.
Topics: Animals; Body Weight; Brain; Cells, Cultured; Chloroquine; Embryo, Nonmammalian; Hot Temperature; Im | 1973 |
Letter: Neuromyopathy during malaria suppression with chloroquine.
Topics: Atrophy; Chloroquine; Electromyography; Female; Humans; Malaria; Neuromuscular Diseases; Reflex | 1973 |
[Malaria prophylaxis].
Topics: Chloroquine; Eye Diseases; Humans; Malaria | 1974 |
[Chloroquine induced neuromyopathy during malaria suppression].
Topics: Adult; Amyotrophic Lateral Sclerosis; Chloroquine; Female; Humans; Malaria; Vitamin B Complex | 1974 |
[A febrile crisis of suspected malarial etiology in a person returning from the tropics].
Topics: Antimalarials; Blood; Chloroquine; Drug Synergism; Fever; Humans; Liver Function Tests; Malaria; Pla | 1974 |
Pigment in asexual erythrocytic forms of chloroquine-resistant Plasmodium falciparum.
Topics: Chloroquine; Erythrocytes; Humans; Malaria; Pigments, Biological; Plasmodium; Plasmodium falciparum | 1967 |
Effects of pyrimethamine, chlorguanide, and primaquine against exoerythrocytic forms of a strain of chloroquine-resistant Plasmodium falciparum from Thailand.
Topics: Adult; Chloroquine; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Primaquine; Proguanil | 1967 |
[Chloroquine-resistant malignant malaria].
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Quinine; South Amer | 1967 |
Interruption of malaria transmission by chloroquinized salt in Guyana, with observations on a chloroquine-resistant strain of Plasmodium falciparum.
Topics: Chloroquine; DDT; Guyana; Humans; Malaria; Plasmodium falciparum | 1967 |
Treatment of acute falciparum malaria with sulfalene and trimethoprim.
Topics: Chloroquine; Folic Acid Antagonists; Humans; Malaria; Male; Plasmodium falciparum; Pyrimethamine; Py | 1968 |
[Resistance in Protozoa].
Topics: Antiprotozoal Agents; Chloroquine; Drug Synergism; Malaria; Plasmodium; Pyrimethamine; Trypanosoma | 1967 |
Antimalarial effects of sulphormethoxine, diaphenylsulphone and separate combinations of these with pyrimethamine: a review of preliminary investigations carried out in Tanzania.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Dapsone; Drug Hypersensitivity; Drug Resistanc | 1968 |
Nephropathy in Malaria.
Topics: Acute Kidney Injury; Adult; Antimalarials; Anuria; Capillaries; Chloroquine; Creatinine; Dextrans; H | 1968 |
[Treatment of "P. falciparum" malaria by delayed-action sulfonamides].
Topics: Antimalarials; Chloroquine; Delayed-Action Preparations; Drug Synergism; Humans; Malaria; Plasmodium | 1967 |
Apparent chloroquine-resistant falciparum malaria from coastal Brazil.
Topics: Brazil; Chloroquine; Drug Resistance, Microbial; Geography; Humans; Malaria; Male; Plasmodium falcip | 1968 |
Cure of vivax malaria.
Topics: Chloroquine; Humans; Malaria; Plasmodium vivax; Primaquine | 1968 |
Childhood splenomegaly in Uganda, and its relation to malaria.
Topics: Biopsy; Child; Child, Preschool; Chloroquine; Female; Fluorescent Antibody Technique; Hemoglobinomet | 1968 |
Early experiences in the treatment of falciparum malaria from Southeast Asia.
Topics: Asia, Southeastern; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Military Medicin | 1968 |
[Chloroquine-resistant malaria in Africa].
Topics: Adult; Chloroquine; Congo; Drug Resistance, Microbial; Humans; Malaria; Male; Nigeria; Plasmodium fa | 1967 |
Surveys on chloroquine resistant P. falciparum in Thailand.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium; Plasmodium falciparum; Plasmod | 1968 |
The sporogonous of Plasmodium vivax in Anopheles mosquitoes as a system for evaluating the prophylactic and curative capabilities of potential antimalarial compounds.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Malaria; Naphthoquinones; Oxytetracycline; Penicilli | 1968 |
Effects of chloroquine, quinine, and cycloguanil upon the maturation of asexual erythrocytic forms of two strains of Plasmodium falciparum in vitro.
Topics: Chloroquine; Culture Techniques; Erythrocytes; Humans; Malaria; Male; Methods; Plasmodium falciparum | 1968 |
Malaria and victory in Vietnam. The first battle against drug-resistant malignant malaria is described.
Topics: Anopheles; Antimalarials; Chloroquine; Folic Acid Antagonists; Folic Acid Deficiency; History, 16th | 1968 |
Oliguric renal failure in blackwater fever.
Topics: Acute Kidney Injury; Adolescent; Adult; Anuria; Biopsy; Black People; Chloroquine; Glucosephosphate | 1968 |
Chloroquine resistance in Plasmodium falciparum malaria on the Pacific coast of Colombia.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Chloroquine; Colombia; Drug Resistanc | 1968 |
Chloroquine-pyrimethamine-sulfisoxazole therapy of Plasmodium falciparum malaria. An alternative to quinine.
Topics: Chloroquine; Dapsone; Drug Resistance, Microbial; Fever; Humans; Malaria; Male; Military Medicine; P | 1969 |
Studies on the relationship between fluorescent antibody response and ecology of malaria in Malaysia.
Topics: Adolescent; Adult; Anopheles; Child; Child, Preschool; Chloroquine; Ecology; Fluorescent Antibody Te | 1968 |
Malaria--a persistent threat.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Military Medicine; Mosquito Control; Plasm | 1969 |
A clinical view of the biology of Plasmodia.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium; Plasmodium falc | 1969 |
Acute falciparum malaria. Field experience with quinine-pyrimethamine combined therapy.
Topics: Chloroquine; Humans; Malaria; Military Medicine; Plasmodium falciparum; Plasmodium vivax; Primaquine | 1969 |
Response to drugs of South American strains of Plasmodium falciparum.
Topics: Chloroquine; Drug Resistance, Microbial; Drug Synergism; Fever; Humans; Malaria; Plasmodium falcipar | 1968 |
Combined pyrimethamine-quinine therapy for chloroquine-resistant P. falciparum infections.
Topics: Adolescent; Adult; Agranulocytosis; Anemia, Hemolytic; Chloroquine; Clinical Laboratory Techniques; | 1969 |
Antimalarial activity of Kelfizina-trimethoprim and Kelfizina-pyrimethamine versus chloroquine in field trials in Nigeria.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Folic Acid Antagonists; Humans; Infant; Mal | 1969 |
Malaria in American soldiers.
Topics: Anemia, Hemolytic; Blood Cell Count; Carrier State; Chloroquine; Hematocrit; Hemoglobinometry; Hepat | 1969 |
Combination therapy of malaria.
Topics: Chloroquine; Humans; Malaria; Plasmodium falciparum; Pyrimethamine; Sulfisoxazole | 1969 |
Malaria (1969).
Topics: Adult; Chloroquine; Humans; Malaria; Male; Military Medicine; Plasmodium falciparum; Plasmodium viva | 1969 |
Chloroquine-resistant P. falciparum infections.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malaysia; Plasmodium falciparum | 1969 |
Current practice in tropical medicine.
Topics: Acute Kidney Injury; Amebiasis; Amebicides; Chloroquine; Cholera; Drug Resistance, Microbial; Hepati | 1969 |
Fatal transfusion malaria.
Topics: Blood Volume; Chloroquine; Chorea; Dehydration; Dexamethasone; Humans; Malaria; Male; Middle Aged; N | 1969 |
Vietnam malaria. Clinical experience with 50 patients.
Topics: Adult; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Primaquine; Quin | 1970 |
Malaria in soldiers returning from Vietnam. Epidemiologic, therapeutic, and clinical studies.
Topics: Adult; Black or African American; Black People; Chloroquine; Chronic Disease; Hospitalization; Human | 1970 |
Reticuloendothelial system phagocytic function in naturally acquired human malaria.
Topics: Adult; Chloroquine; Female; Fluorescent Antibody Technique; Humans; Malaria; Male; Middle Aged; Mono | 1970 |
Chloroquine-resistant malaria in Singapore.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum; Singapore | 1969 |
[The possible presence in Cameroon of chloroquine resistant strains of Plasmodium falciparum].
Topics: Adolescent; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Mala | 1970 |
A case of transfusion malaria due to Plasmodium falciparum with antibody studies of the donors.
Topics: Antibodies; Blood Donors; Chloroquine; Fluorescent Antibody Technique; Humans; Malaria; Male; Plasmo | 1970 |
Fatal pulmonary edema as a complication of acute falciparum malaria.
Topics: Adolescent; Adult; Cephalosporins; Chloroquine; Digitalis Glycosides; Humans; Hypersensitivity; Mala | 1970 |
Fluorescent-antibody patterns in naturally acquired vivax malaria.
Topics: Chloroquine; Fluorescent Antibody Technique; Humans; Malaria; Male; Plasmodium vivax; Primaquine; Pr | 1970 |
The effect of small single doses of cloroquine on Plasmodium faiparum infections in north-eastern Tanzania.
Topics: Adolescent; Adult; Carrier State; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; | 1970 |
The importance of chloroquine resistant malaria in Singapore in 1969.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Singapore | 1970 |
Response of Laotian malaria strains to chemotherapy.
Topics: Adult; Antimalarials; Asian People; Chloroquine; Drug Resistance, Microbial; Humans; Japan; Laos; Ma | 1970 |
[Results of radical therapy in cases of tertian malaria in persons returning from the tropics].
Topics: Adult; Chloroquine; Drug Synergism; Humans; Malaria; Male; Middle Aged; Plasmodium vivax; Primaquine | 1970 |
The nephrotic syndrome and Plasmodium malariae in the Yemen Arab Republic.
Topics: Child; Child, Preschool; Chloroquine; Female; Humans; Malaria; Male; Nephrotic Syndrome; Plasmodium | 1971 |
The reappearance of malaria in the USA.
Topics: Blood Donors; Chloroquine; Disease Reservoirs; Drug Resistance, Microbial; Humans; Malaria; Plasmodi | 1970 |
Eradication of gametocytes to prevent introduction of falciparum malaria.
Topics: Chloroquine; Female; Genetics, Microbial; Humans; Malaria; Male; Ovum; Plasmodium falciparum; Primaq | 1971 |
Case of Plasmodium vivax malaria contracted in Southern Europe.
Topics: Adult; Chloroquine; England; Humans; Italy; Malaria; Male; Mediterranean Islands; Plasmodium vivax; | 1971 |
[Malaria in Rostock].
Topics: Acute Kidney Injury; Africa, Western; Chloroquine; Exchange Transfusion, Whole Blood; Germany, East; | 1971 |
Experience with an insecticide-drug combination and observations on suppressive chloroquine-pyrimethamine treatment.
Topics: Child; Chloroquine; DDT; Humans; Malaria; Malaysia; Mosquito Control; Plasmodium falciparum; Plasmod | 1971 |
An Australian experience with malaria.
Topics: Australia; Chloroquine; Humans; Malaria; Malaysia; Military Personnel; New Guinea; Plasmodium vivax; | 1971 |
Plasmodium vivax from Vietnam. Response to chloroquine-primaquine.
Topics: Administration, Oral; Chloroquine; Humans; Malaria; Male; Plasmodium vivax; Primaquine; Vietnam | 1971 |
Malaria in Edinburgh.
Topics: Abscess; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Hemochromatosis; Humans | 1971 |
Malaria at Nam Ngum Dam construction site in Laos. I. Suppression with combinations of sulfonamides and pyrimethamine.
Topics: Chloroquine; Female; Humans; Laos; Leukopenia; Malaria; Male; Plasmodium falciparum; Plasmodium mala | 1971 |
Transfusion-induced falciparum malaria.
Topics: Administration, Oral; Adult; Blood Donors; Carrier State; Chloroquine; Humans; Hypertension; Hyperth | 1971 |
Determination of the drug sensitivity of Plasmodium falciparum.
Topics: Acute Disease; Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Folic Acid Antag | 1971 |
Chloroquine-resistant falciparum malaria among British service personnel in West Malaysia and Singapore.
Topics: Chloroquine; Drug Resistance, Microbial; Ethnicity; Humans; Malaria; Malaysia; Male; Military Medici | 1971 |
Chloroquine resistant malaria in children from a Chinese albino family in Pulau Tekong.
Topics: Albinism; Antimalarials; Child; Child, Preschool; China; Chloroquine; Drug Resistance, Microbial; Fe | 1971 |
Malaria revisited.
Topics: Chloroquine; Humans; Malaria; Military Medicine; Plasmodium falciparum; Plasmodium vivax; Primaquine | 1971 |
Curative and suppressive treatment of P. falciparum malaria with oral and parenteral Fansidar.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Chloroquine; Dapson | 1971 |
Antimalarial effects of tetracyclines in man.
Topics: Adult; Body Temperature; Chloroquine; Doxycycline; Humans; Malaria; Male; Middle Aged; Oxytetracycli | 1971 |
Malaria resistant to chloroquine and sulphamethoxine-pyrimethamine.
Topics: Adult; Aniline Compounds; Chloroquine; Drug Resistance, Microbial; Drug Synergism; Humans; Malaria; | 1971 |
Effects of tetracycline against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum.
Topics: Administration, Oral; Body Temperature; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Ma | 1971 |
Malaria suppression and prophylaxis on a Malaysian rubber estate: sulformethoxine-pyrimethamine single monthly dose vs chloroquine single weekly dose.
Topics: Adolescent; Adult; Aged; Blood; Child; Child, Preschool; Chloroquine; Drug Combinations; Female; Hum | 1971 |
Murine malaria. IV. Disturbed immunological responsiveness during Plasmodium berghei infection.
Topics: Aminobenzoates; Animals; Antibody Formation; Antibody Specificity; Chloroquine; Diet; Erythrocytes; | 1971 |
Chloroquine resistance of Plasmodium falciparum in Brazil detected by a simple in vitro method.
Topics: Brazil; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Methods; Microbial Sensitivity Tes | 1971 |
Acquired decrease in sensitivity to quinine observed during studies with a strain of chloroquine-resistant Plasmodium falciparum.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum; Pyrime | 1967 |
Clinical experience with sulphadiazine and pyrimethamine in the treatment of persons experimentally infected with chloroquine-resistant Plasmodium falciparum.
Topics: Adult; Antimalarials; Body Temperature; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Ma | 1967 |
The routine treatment of malaria.
Topics: Acute Disease; Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Chronic Disease | 1971 |
[First attacks of Plasmodium falciparum malaria. 5 recent observations].
Topics: Adult; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum | 1971 |
A trial of chloroquine-medicated salt for malaria suppression in Uganda.
Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Chloroquine; Female; Humans; Infan | 1967 |
[Intranuclear inclusion in the trophozoite of the erythrocytic form of Plasmodium berghei in the rat by chloroquine absorption].
Topics: Animals; Cell Nucleus; Chloroquine; Erythrocytes; In Vitro Techniques; Malaria; Microscopy, Electron | 1965 |
Chloroquine-resistant Plasmodium falciparum: protective and hemolytic effects of 4,4'-diaminodiphenylsulfone (DDS) administered daily together with weekly chloroquine and primaquine.
Topics: Adult; Black or African American; Chloroquine; Dapsone; Hemolysis; Humans; Malaria; Male; Plasmodium | 1967 |
A case of babesiosis in man in the United States.
Topics: Agglutination Tests; Animals; Babesiosis; Chloroquine; Complement Fixation Tests; Eukaryota; Fluores | 1968 |
Alterations of red blood cell sodium transport during malarial infection.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Chloroquine; Cricetinae; Erythrocytes; Ha | 1969 |
Immunological studies with simian malarias. I. Antigenic variants of Plasmodium cynomolgi bastianellii.
Topics: Animals; Anopheles; Antigens; Blood; Chloroquine; Chronic Disease; Female; Haplorhini; Immunity; Mal | 1969 |
Some aspects of the antimalarial action of chloroquine.
Topics: Animals; Chloroquine; Cytoplasm; Depression, Chemical; DNA; Haplorhini; In Vitro Techniques; Malaria | 1969 |
Immunological studies with simian malarias. II. Heterologous immunity in the "cynomolgi" group.
Topics: Animals; Blood; Chloroquine; Chronic Disease; Haplorhini; Immunity; Malaria; Plasmodium; Species Spe | 1969 |
The influence of methylene blue on the pentose phosphate pathway in erythrocytes of monkeys infected with Plasmodium knowlesi.
Topics: Animals; Carbon Isotopes; Chloroquine; DNA; Erythrocytes; Glucose; Haplorhini; Isoleucine; Malaria; | 1969 |
Uptake of chloroquine-3-H3 by plasmodium knowlesi in vitro.
Topics: Albumins; Animals; Chloroquine; Cyanates; Dinitrophenols; Erythrocytes; Fluorides; Glucose; Haplorhi | 1969 |
Malaria research at the National Institute of Allergy and Infectious Diseases.
Topics: Animals; Chloroquine; Disease Models, Animal; Haplorhini; Humans; Malaria; National Institutes of He | 1969 |
Effects of quinine and of chloroquine in vitro against a strain of chloroquine-resistant Plasmodium falciparum that displays a relative resistance to quinine in vivo.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malaysia; Male; Plasmodium | 1969 |
New insights into the fine structure of rodent malarial parasites.
Topics: Animals; Chloroquine; Erythrocytes; Malaria; Methods; Mice; Microscopy, Electron; Morphogenesis; Pla | 1969 |
The identity of chloroquine induced nucleolar aggregates in malaria.
Topics: Animals; Anura; Blood Proteins; Cell Nucleus; Chloroquine; Cytoplasmic Granules; Ferritins; Humans; | 1969 |
[Chemotherapeutic activity of standard antimalarials in a simplified test for Plasmodium vinckey infection in the NMPI mouse].
Topics: Animals; Antimalarials; Chloroquine; Long-Term Care; Malaria; Mice; Plasmodium; Primaquine; Pyrimeth | 1970 |
Antimicrobial activity of the leprostatic drug 3-(p-chloranilino)-10-(p-chlorphenyl-2,10-dihydro-2-(isopropylimino)-phenazine (G 30'320, B. 663).
Topics: Animals; Antitubercular Agents; Aspergillosis; Candidiasis; Chloroquine; Cricetinae; Disease Models, | 1970 |
Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity.
Topics: Animals; Carbon Isotopes; Chloroquine; Disease Models, Animal; Drug Resistance, Microbial; Erythrocy | 1970 |
The successful control of malaria in the 173d Airborne Brigade.
Topics: Aerospace Medicine; Chloroquine; Humans; Malaria; Male; Methods; United States; Vietnam | 1970 |
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial | 1970 |
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial | 1970 |
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial | 1970 |
Infection with chloroquine-resistant Plasmodium falciparum in man: prepatent periods, incubation periods, and relationships between parasitemia and the onset of fever in nonimmune persons.
Topics: ABO Blood-Group System; Adult; Anopheles; Blood Transfusion; Chloroquine; Drug Resistance, Microbial | 1970 |
Observations on the relapse activity of Plasmodium fieldi in the rhesus monkey.
Topics: Aedes; Animals; Chloroquine; Chronic Disease; Disease Models, Animal; Haplorhini; Insect Vectors; Ma | 1971 |
Prophylaxis of malaria in man using the sulfones DFD and DDS alone and with chloroquine.
Topics: Adult; Chloroquine; Dapsone; Humans; Malaria; Male; Sulfones | 1971 |
Chloroquine-resistant malaria?
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Kenya; Malaria | 1972 |
Malaria: the effect of iron and chloroquine on the erythrocytic forms of Plasmodium berghei.
Topics: Animals; Chloroquine; Erythrocytes; Iron; Iron Isotopes; Malaria; Mice; Plasmodium | 1972 |
Hereditary elliptocytosis associated with severe haemolytic anaemia and malaria.
Topics: Anemia, Hemolytic; Child, Preschool; Chloroquine; Elliptocytosis, Hereditary; Erythrocytes, Abnormal | 1972 |
Confusion or confidence in chloroquine.
Topics: Administration, Oral; Chloroquine; Drug Resistance, Microbial; Humans; Injections, Intravenous; Keny | 1972 |
An overdose of chloroquine.
Topics: Chloroquine; Chromatography, Thin Layer; Female; Heroin; Humans; Malaria; Substance-Related Disorder | 1972 |
[Causal preventive activity of standard antimalarials in rodent malaria (Plasmodium berghei yoelii)].
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Malaria; Mice; Mice, Inbred Strains; Plasmodium; Pri | 1972 |
Antimalarial activity of erythromycin.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythromycin; Malaria; Mice | 1972 |
The role of drugs in a malaria program.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Primaqui | 1972 |
Tetracyclines for malaria.
Topics: Chloroquine; Drug Combinations; Humans; Malaria; Quinine; Tetracycline | 1972 |
The chemotherapy of rodent malaria. XIV. The action of some sulphonamides alone or with folic reductase inhibitors against malaria vectors and parasites. 4. The response of normal and drug-resistant strains of Plasmodium berghei.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Folic Acid Antagonists; Malaria; Male; Mice; Prima | 1971 |
Cytotoxic agents and haemozoin pigment in malaria parasites (Plasmodium berghei).
Topics: Animals; Antineoplastic Agents; Azaserine; Chloramphenicol; Chloroquine; Cycloheximide; Cytoplasm; D | 1971 |
The effect of cytotoxic agents on autophagic vacuole formation in chloroquine-treated malaria parasites (Plasmodium berghei).
Topics: Animals; Antineoplastic Agents; Azaserine; Chloroquine; Colchicine; Cycloheximide; Cytoplasm; Dactin | 1971 |
Acute febrile encephalopathy in Ugandan children.
Topics: Cerebrospinal Fluid; Child; Child, Preschool; Chloroquine; Encephalitis; Female; Fever; Gastrointest | 1971 |
Relapse activity in sporozoite-induced infections with a West African strain of Plasmodium ovale.
Topics: Africa, Western; Anopheles; Chloroquine; Humans; Malaria; Male; Plasmodium; Quinine; Recurrence; Tim | 1971 |
[Delagil treatment of malarial coma].
Topics: Adult; Chloroquine; Coma; Female; Humans; Malaria | 1971 |
[Cerebral forms of malaria].
Topics: Adolescent; Adult; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Neurologic Manifestation | 1971 |
[Antimalarial chemoprophylaxis and immunity].
Topics: Antibody Formation; Chloroquine; Humans; Infant; Malaria; Time Factors | 1971 |
Malaria in childhood.
Topics: Child, Preschool; Chloroquine; Female; Humans; Infant; Malaria; Male; Nigeria; Pyrimethamine | 1971 |
A case of congenital malaria.
Topics: Chloroquine; Female; Humans; Infant, Newborn; Malaria; Male; Pregnancy | 1971 |
[Effectiveness of trypanocides berenil and pentamidine in rodent malaria (Plasmodium vinckei)].
Topics: Acetates; Amidines; Animals; Antimalarials; Azo Compounds; Chloroquine; Cresols; Glycine; Malaria; P | 1971 |
Falciparum malaria. Report of two cases in children.
Topics: Africa; Black or African American; Black People; Child; Child, Preschool; Chloroquine; Humans; In Vi | 1966 |
The ocular toxicity of chloroquine.
Topics: Chloroquine; Electrooculography; Eye Diseases; Humans; Macula Lutea; Malaria; Methods; Vision Tests | 1967 |
Chloroquine resistance in malaria: a deficiency of chloroquine binding.
Topics: Animals; Carbon Isotopes; Chloroquine; Erythrocytes; Malaria; Male; Mice; Plasmodium; Receptors, Dru | 1969 |
Studies on alleged chloroquine-resistance of malaria parasites in Axim and Obuasi, Ghana.
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Ghana; Humans; | 1968 |
Heterophile antibodies, M-antiglobulins, immunoglobulins and acute phase proteins in pregnancy in Nigeria.
Topics: Antibodies; Antibodies, Anti-Idiotypic; C-Reactive Protein; Ceruloplasmin; Chloroquine; Female; Huma | 1970 |
Chloroquine metabolism in kwashiorkor.
Topics: Child; Chloroquine; Humans; Kwashiorkor; Malaria | 1970 |
Studies on the antimalarial effects of cycloguanil pamoate (CI-501) in man.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Proguani | 1965 |
Observations on an apparent chloroquine-resistant strain of Plasmodium falciparum in West Africa.
Topics: Black or African American; Black People; Burkina Faso; Child; Child, Preschool; Chloroquine; Humans; | 1965 |
The therapy of cerebral malaria in children. Editorial comment.
Topics: Blood; Brain Diseases; Child; Child, Preschool; Chloroquine; Female; Humans; Malaria; Male; Plasmodi | 1966 |
Prevalence of malaria exhibiting reduced sensitivity to chloroquine in Southern Thailand.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; H | 1966 |
Vivax malaria complicated by aphasia and hemiparesis.
Topics: Adult; Aphasia; Body Temperature; Cerebrovascular Disorders; Chloroquine; Hematocrit; Hemiplegia; Hu | 1963 |
[Natural and acquired resistance to malaria: a model case].
Topics: Chloroquine; Fluorescent Antibody Technique; Glucosephosphate Dehydrogenase Deficiency; Humans; Immu | 1967 |
Depletion of coagulation factors in drug-resistant Plasmodium falciparum malaria.
Topics: Adult; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Chloroquine; Dr | 1967 |
Management of chloroquine-resistant falciparum malaria.
Topics: Asia, Southeastern; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Military Medicine; Pla | 1967 |
Management of chloroquine resistant falciparum malaria.
Topics: Adult; Brain Diseases; Chloroquine; Dapsone; Dexamethasone; Drug Resistance, Microbial; Edema; Human | 1967 |
Imported falciparum malaria with inadequate response to chloroquine.
Topics: Adult; Ambulatory Care; Chloroquine; Communicable Disease Control; Humans; Japan; Malaria; Male; Pla | 1966 |
Drug resistance of malaria parasites in Tanzania.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Quinolines; Tanzani | 1966 |
Transfusion malaria in an infant in Singapore.
Topics: Asian People; Chloroquine; Cold Temperature; Erythrocytes; Humans; Infant; Malaria; Malaysia; Male; | 1969 |
[Symptomatology, diagnosis and therapy of malaria].
Topics: Chloroquine; Diagnosis, Differential; Erythrocytes; Humans; Malaria; Plasmodium; Primaquine; Quinine | 1969 |
Plasmodium vinckei: production of chloroquine-resistant strain.
Topics: Animals; Antimalarials; Arsenicals; Chloroquine; Cytoplasm; Drug Resistance, Microbial; Malaria; Met | 1969 |
[Retinal degeneration in 2 children following preventive antimalarial treatment of the mother during pregnancy].
Topics: Adolescent; Adult; Chloroquine; Female; Fetal Diseases; Humans; Malaria; Pregnancy; Pregnancy Compli | 1969 |
Cortical blindness following convulsions and fever in Nigerian children.
Topics: Anti-Bacterial Agents; Anticonvulsants; Blindness; Blood Transfusion; Bronchopneumonia; Cerebral Cor | 1970 |
[Drug resistant malaria].
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria | 1970 |
Relapse after standard treatment of malaria.
Topics: Adult; Chloroquine; Chronic Disease; Humans; Malaria; Male; Primaquine | 1970 |
Is malaria chemosuppression necessary in an infant?
Topics: Age Factors; Amodiaquine; Chloroquine; Disease Reservoirs; Humans; Infant, Newborn; Infant, Newborn, | 1970 |
Theory for the mechanism of chloroquine resistance in rodent malaria.
Topics: Animals; Chloroquine; Citric Acid Cycle; Drug Resistance, Microbial; Erythrocytes; Histocytochemistr | 1970 |
Parenteral chloroquine in children.
Topics: Child; Child, Preschool; Chloroquine; Drug Hypersensitivity; Female; Humans; Infant; Injections, Int | 1970 |
The chemotherapy of rodent malaria. IX. Causal prophylaxis. I. A method for demonstrating drug action on exo-erythrocytic stages.
Topics: Animals; Antimalarials; Chloroquine; Dapsone; Malaria; Male; Mice; Plasmodium; Primaquine; Proguanil | 1970 |
The chemotherapy of rodent malaria. X. Dynamics of drug resistance. II. Acquisition and loss of chloroquine resistance in Plasmodium berghei observed by continuous bioassay.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Germ Cells; Malaria; Male; Mice; Plasmodium | 1970 |
The chemotherapy of rodent malaria. XI. Cyclically transmitted, chloroquine-resistant variants of the Keyberg 173 strain of Plasmodium berghei.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Germ Cells; Malaria; Male; Mice; Pla | 1970 |
Cerebral malaria.
Topics: Adult; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Quini | 1970 |
Nonspecific phagocytic activity in rats infected with Plasmodium berghei and treated with amodiaquine or chloroquine.
Topics: Amodiaquine; Animals; Body Weight; Carbon; Chloroquine; Colloids; Injections, Intravenous; Liver; Lu | 1970 |
Acute malaria in newborn infants.
Topics: Acute Disease; Chloroquine; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Malaria | 1970 |
[New 6-aminoquinolines with antimalarial activity. Test results on schizontocidal and causalprophylactic effects in rodent- and avian malaria (Plasmodium vinckei, P. berghei and P. cathemerium)].
Topics: Amines; Animals; Antimalarials; Canaries; Chloroquine; Drug Resistance, Microbial; Injections, Intra | 1970 |
A medicated salt project in the Kazeroun area, Iran--1962-1967.
Topics: Amodiaquine; Anopheles; Blood; Child; Child, Preschool; Chloroquine; Humans; Infant; Infant, Newborn | 1971 |
Malaria chemoprophylaxis.
Topics: Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Emigration and Immigration; Female; Huma | 1971 |
Barrier spraying at the Kelantan side of the Thai-Malaysia border.
Topics: Anopheles; Child; Chloroquine; DDT; Dieldrin; Housing; Humans; Insect Vectors; Insecticide Resistanc | 1971 |
Pathologic physiology and chemotherapy of Plasmodium berghei. II. Oxyhemoglobin dissociation curve in mice infected with chloroquine-sensitive and resistant strains.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Hemoglobinometry; Hemoglobins; Hydro | 1967 |
[Prophylaxis versus suppression of malaria].
Topics: Chloroquine; Humans; Malaria; Proguanil; Pyrimethamine | 1967 |
[Tropical diseases treated at Roslagstulls Hospital].
Topics: Adolescent; Adult; Aged; Amebiasis; Anti-Bacterial Agents; Antimony; Child; Chloroquine; Diethylcarb | 1967 |
Falciparum malaria in the United States. Report of a case in a South Viet Nam veteran.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Military Personnel; Plasmodiu | 1967 |
Chloroquine-resistant falciparum malaria.
Topics: Chloroquine; Humans; Malaria; Military Medicine; Pyrimethamine; Quinine; Vietnam | 1967 |
Chloroquine-resistant falciparum malaria.
Topics: Chloroquine; Humans; Injections, Intramuscular; Injections, Intravenous; Malaria; Quinine | 1967 |
Treatment of malaria.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Military Medicine; Quinine; Tropical Medicine; Vietnam | 1968 |
Synthesis and antimalarial evaluation of some 1,7-nephthyridines and 2,9-diazaanthracenes.
Topics: Animals; Benzene Derivatives; Chloroquine; Malaria; Methods; Mice; Naphthyridines; Quinacrine | 1968 |
Psychiatric complications with chloroquine and quinacrine.
Topics: Anti-Inflammatory Agents; Chloroquine; Humans; Malaria; Malingering; Psychoses, Substance-Induced; Q | 1968 |
Antiplasmodial activity of 7-halogenated lincomycins.
Topics: Animals; Antimalarials; Chlorine; Chloroquine; Lincomycin; Malaria; Mice | 1968 |
[Malaria therapy: quinine again in style].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; History, 19th Century; History, 20t | 1968 |
Use of dexamethasone in cerebral malaria.
Topics: Adult; Brain Edema; Chloroquine; Coma; Dexamethasone; Humans; Malaria; Male | 1968 |
[Management of acute malaria].
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Injections, Intramuscular; Malaria; Primaquine; Tro | 1968 |
[The treatment of tropical malaria resistant to chloroquine].
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria | 1968 |
Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam.
Topics: Antimalarials; Chloroquine; Cyanosis; Dapsone; Diseases in Twins; Erythrocytes; Female; Hematocrit; | 1968 |
Characteristics and cross-resistance patterns of chloroquine-resistant Plasmodium berghei infections in mice.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Female; Hemat | 1968 |
Chloroquine seizures. Report of four cases.
Topics: Adult; Chloroquine; Dysentery, Amebic; Epilepsy; Female; Hepatitis; Humans; Malaria | 1968 |
The chemotherapy of rodent malaria. I. Host-parasite relationships. I. The virulence of infection in relation to drug resistance and time elapsed since isolation of the 'wild' strain.
Topics: Animals; Chloroquine; Congo; Drug Resistance, Microbial; Malaria; Mice; Plasmodium; Rodent Diseases; | 1968 |
The chemotherapy of rodent malaria. 3. Host-parasite relationships. 3. The relationship between haemozoin formation and the age of the host cell.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocyte Aging; Hemoglobins; Malaria; Male; Mic | 1968 |
The chemotherapy of rodent malaria. IV. Host-parasite relationships. 4. The relationship between haemozoin formation and host-cell age in chloroquine- and primaquine-resistant strains of Plasmodiun berghei.
Topics: Animals; Chloroquine; Cytoplasm; Drug Resistance, Microbial; Erythrocyte Aging; Hemoglobins; Malaria | 1968 |
The chemotherapy of rodent malaria. V. Dynamics of drug resistance. I. Methods for studying the acquisition and loss of resistance to chloroquine by Plasmodiun berghei.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Malaria; Male; Methods; Mice; Plasmo | 1968 |
The effect of betamethasone on acquired immunity to Plasmodium vinckei in mice.
Topics: Animals; Antibody Formation; Betamethasone; Chloroquine; Immunity, Active; Malaria; Male; Mice; Plas | 1968 |
Measurement of the growth rate of the erythrocytic stages of Plasmodium berghei and comparisons of the potency of inocula after various treatments.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Injections, Intravenous; Malaria; Ma | 1968 |
Chloroquine-resistant malaria in West Malaysia.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malaysia | 1968 |
Pathologic physiology and chemotherapy of Plasmodium berghei. IV. Influence of chloroquine on oxygen uptake of red blood cells infected with sensitive or resistant strains.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocyte Count; Erythrocytes; Hemoglobins; Mala | 1968 |
Parasitemia and erythrocyte destruction in Plasmodium berghei-infected rats. II. Effect of infected host globulin.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Chloroquine; Chromium Isotopes; Erythrocytes; Malaria; | 1968 |
The chemotherapy of rodent malaria. II. Host-parasite relationships. 2. The relationship between chloroquine sensitivity and the age of the host cell.
Topics: Animals; Blood; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Malaria; Plasmodium; Rodent D | 1968 |
The schizonticidal activity of hydroxynaphthoquinones against Plasmodium berghei infections in mice.
Topics: Animals; Antimalarials; Chloroquine; Malaria; Mice; Naphthoquinones; Plasmodium | 1968 |
Causal prophylactic effect of Menoctone (a new hydroxynaphthoquinone) against sporozoite-induced Plasmodium berghei infection in mice.
Topics: Animals; Antimalarials; Chloroquine; Cricetinae; Malaria; Mice; Naphthoquinones; Plasmodium; Primaqu | 1968 |
Malaria--the British point of view.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malaysia; Military Medicine; Proguanil; Py | 1969 |
The Plasmodium chabaudi-mouse system in chemotherapy studies.
Topics: Animals; Antimalarials; Chloroquine; Injections, Intravenous; Malaria; Male; Mice; Plasmodium; Prima | 1969 |
Antimalarials. Unsaturation in chloroquine side chain and antimalarial activity.
Topics: Animals; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Malaria; Mice; Plasmodium; Stere | 1969 |
Comparative response of various rodent malarias to chemotherapy.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Malaria; Male; Mice; Pyrimethamine | 1969 |
A virulent chloroquine-resistant strain of Plasmodium berghei berghei transmitted through Anopheles stephensi.
Topics: Animals; Anopheles; Chloroquine; Drug Resistance, Microbial; Malaria; Male; Mice; Plasmodium; Virule | 1969 |
The sites of deep vascular schizogony in chloroquine-resistant Plasmodium berghei in mice.
Topics: Animals; Bone Marrow; Brain; Chloroquine; Drug Resistance, Microbial; Female; Heart; Kidney; Liver; | 1969 |
Malaria imported to the United States from Vietnam. Chemoprophylaxis evaluated in returning soldiers.
Topics: Adult; Attitude to Health; Chloroquine; Humans; Malaria; Male; Military Medicine; Primaquine; United | 1969 |
Cerebral malaria following blood transfusion.
Topics: Adult; Brain Diseases; Chloroquine; Communicable Disease Control; Disease Reservoirs; Humans; Malari | 1969 |
Pathologic physiology and chemotherapy of Plasmodium berghei. VI. Mechanical properties and histological features of the lung.
Topics: Acidosis, Respiratory; Animals; Chloroquine; Lung; Lung Compliance; Malaria; Mice; Plasmodium; Pulmo | 1969 |
Infectivity of chloroquine resistant Plasmodium berghei to Anopheles stephensi enhanced by chloroquine.
Topics: Animals; Anopheles; Biological Assay; Chloroquine; Drug Resistance, Microbial; Malaria; Models, Biol | 1969 |
Achalasia of the oesophagus and resistant malaria.
Topics: Adult; Chloroquine; Esophageal Achalasia; Female; Humans; Malaria; Radiography, Thoracic | 1969 |
Comparative toxicity of chloroquine and bis[(chloro-7"-quinolyl-4")-amino-2'propyl]-1,4-piperazine (WR 3863).
Topics: Animals; Animals, Newborn; Antimalarials; Aorta; Blood Pressure; Cardiac Output; Cats; Chloroquine; | 1969 |
Chloroquine psychosis.
Topics: Adult; Chloroquine; Female; Humans; Malaria; Psychoses, Substance-Induced | 1969 |
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance.
Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Malaria; Mice; Plasmodium; Primaquine; Proguanil; Pyrime | 1965 |
[Resistance of Plasmodium berghei to chloroquine and 4-aminoquinolines].
Topics: Animals; Chloroquine; In Vitro Techniques; Malaria; Mice; Quinolines | 1965 |
[Standardization of chemotherapy of rodent malaria (Plasmodium berghei) on NMRI mice].
Topics: Animals; Body Temperature; Body Weight; Chloroquine; Injections, Intraperitoneal; Malaria; Mice; Qui | 1965 |
A recently isolated West African strain of plasmodium ovale.
Topics: Africa, Western; Chloroquine; Humans; In Vitro Techniques; Malaria; Plasmodium | 1966 |
Daraclor trial.
Topics: Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Infant, Newborn; Malaria; Male; Pyrime | 1966 |
Transfusion malaria. Seven affected infants.
Topics: Chloroquine; Female; Greece; Humans; Iatrogenic Disease; Infant; Malaria; Male; Primaquine; Transfus | 1966 |
Anaemia in pregnancy associated with "big spleen disease".
Topics: Adolescent; Adult; Anemia, Hypochromic; Chloroquine; Female; Humans; Liver; Malaria; Pregnancy; Preg | 1966 |
Serum haptoglobin values in 39 malnourished Uganda children.
Topics: Adult; Anemia; Blood Chemical Analysis; Blood Protein Electrophoresis; Child, Preschool; Chloroquine | 1966 |
Chloroquine: physiological basis of drug resistance in Plasmodium berghei.
Topics: Animals; Carbon Isotopes; Chloroquine; Drug Resistance, Microbial; Erythrocytes; In Vitro Techniques | 1966 |
An assessment of the sporozoite inoculation rate as a measure of malaria transmission in the Ubembe area of North-east Tanzania.
Topics: Animals; Anopheles; Child; Child, Preschool; Chloroquine; Humans; Hyperthermia, Induced; Malaria; Pr | 1966 |
Acquired immunity to Plasmodium vinckei in mice.
Topics: Animals; Chloroquine; Malaria; Mice; Plasmodium; Species Specificity; Splenectomy | 1966 |