chloroquine has been researched along with Malaria, Falciparum in 1617 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyronaridine-artesunate was recently strongly recommended in the 2022 update of the WHO Guidelines for the Treatment of Malaria, becoming the newest artemisinin-based combination therapy (ACT) for both uncomplicated Plasmodium falciparum and Plasmodium vivax malaria." | 9.41 | Pyronaridine: a review of its clinical pharmacology in the treatment of malaria. ( Chu, WY; Dorlo, TPC, 2023) |
| "A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries." | 9.22 | Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review. ( Bwire, GM; Chamani, AT; Mutagonda, RF; Mwakyandile, T; Njiro, BJ; Sabas, D, 2022) |
| "The World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in African regions with moderate to high malaria transmission." | 9.22 | Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial. ( Ayoub, A; Duparc, S; Kamiza, S; Kimani, J; Orrico, R; Phiri, K; Robbins, J; Rojo, R; Vandenbroucke, P, 2016) |
| "This was an open-label, non-comparative study (NCT01103713) in 5 countries in East and sub-Saharan Africa (Benin, Kenya, Malawi, Tanzania, and Uganda) to assess parasitological response and drug concentrations of a single, 3-day course of four tablets of a fixed-dose combination of azithromycin-chloroquine (AZCQ) 250/155 mg given during the second or third trimester to women with asymptomatic Plasmodium falciparum parasitemia in their first or second pregnancy." | 9.22 | Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. ( Ayoub, A; Duparc, S; Kimani, J; Mtove, GA; Phiri, K; Robbins, J; Rojo, R; Vandenbroucke, P; Zhao, Q, 2016) |
| "In India, till recently, Chloroquine was used as first-line therapy in areas with Chloroquine sensitive Plasmodium falciparum malaria cases." | 9.15 | Efficacy of chloroquine and sulphadoxine-pyrimethamine either alone or in combination before introduction of ACT as first-line therapy in uncomplicated Plasmodium falciparum malaria in Jalpaiguri District, West Bengal, India. ( Bera, DK; Biswas, A; Das, M; Das, S; Guha, SK; Kundu, PK; Maji, AK; Mullick, S; Ray, K; Roy, D; Saha, P; Sengupta, S, 2011) |
| "In order to determine the pharmacokinetic disposition of chloroquine (CQ) and its active metabolite, desethylchloroquine (DECQ), when administered as intermittent presumptive treatment in pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third trimester of pregnancy and 30 age-matched nonpregnant women were administered three daily doses of 450 mg CQ (8." | 9.14 | Pharmacokinetics of chloroquine and monodesethylchloroquine in pregnancy. ( Baiwog, F; Davis, TM; Gomorrai, S; Ilett, KF; Karunajeewa, HA; Law, I; Mueller, I; Page-Sharp, M; Rogerson, S; Salman, S; Siba, P, 2010) |
| "Among 975 primary treatment courses, the cumulative 28-day curative efficacies were 26% and 82% for chloroquine against Plasmodium falciparum malaria and Plasmodium vivax malaria, respectively." | 9.12 | Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. ( Baird, JK; Fryauff, DJ; Maguire, JD; Marwoto, H; Richie, TL, 2006) |
| "Amodiaquine alone or in combination with sulphadoxine-pyrimethamine, although associated with minor side-effects, is effective when used to treat malaria in pregnancy." | 9.12 | Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial. ( Browne, E; Bruce, J; Chandramohan, D; Greenwood, B; Randal, A; Tagbor, H, 2006) |
| "To assess the safety of chloroquine (CQ) as prophylaxis against Plasmodium vivax infection during pregnancy." | 9.12 | Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, double-blind, placebo-controlled trial. ( Arunjerdja, R; Greenwood, B; Htway, M; McGready, R; Nosten, F; Paw, MK; Pimanpanarak, M; Viladpai-Nguen, SJ; Villegas, L; White, NJ, 2007) |
| "A study of the therapeutic efficacy of combined chloroquine and sulfadoxine-pyrimethamine (SP) for the treatment of uncomplicated Plasmodium falciparum malaria was carried out from June to November 2002, using the standard protocol recommended by the WHO for a low-to-moderate transmission area, in two sentinel sites in Bangladesh: Alikadam Upazilla in Bandarban district and Matiranga Upazilla in Khagrachari district." | 9.11 | Efficacy of combined chloroquine and sulfadoxine-pyrimethamine in uncomplicated Plasmodium falciparum malaria in Bangladesh. ( Bangali, M; Das, S; Rahman, M; Rahman, R; Ringwald, P; Talukder, MR, 2004) |
| "The efficacy of a single dose of 45 mg primaquine, as a gametocytocidal agent, was assessed in Mumbai, India, among adults with uncomplicated or severe Plasmodium falciparum malaria." | 9.11 | A prospective study evaluating the efficacy of a single, 45-mg dose of primaquine, as a gametocytocidal agent, in patients with Plasmodium falciparum malaria in Mumbai, India. ( Aigal, U; Chogle, AR; Dalvi, SS; Gogtay, NJ; Kamtekar, KD; Karnad, DR; Kshirsagar, NA, 2004) |
| "In November-December 2002, 98 patients presented at the Elhara Eloula health centre, in the New Halfa area of eastern Sudan, with Plasmodium falciparum malaria that had failed to respond to chloroquine treatment." | 9.11 | Low-dose quinine is effective in the treatment of chloroquine-resistant Plasmodium falciparum malaria in eastern Sudan. ( Adam, I; Aelbasit, IA; Elbashir, MI; Ibrahim, MH; Kheir, MM; Naser, A, 2004) |
| "At a public hospital in Georgetown, Guyana, 44 patients seeking treatment for symptomatic, slide-confirmed malaria were given standard chloroquine (CQ) therapy and followed for 28 days." | 9.10 | Chloroquine for the treatment of uncomplicated malaria in Guyana. ( Baird, JK; Bravet, PP; Carucci, D; Ferrel, M; Hoffman, SL; Martin, GJ; Prout, TM; Rawlins, S; Tamminga, CL; Tiwari, T; Tjaden, J, 2002) |
| "The effects of chloroquine (CQ), amodiaquine (AQ) and CQ plus chlorpheniramine (a histamine H(1) antagonist that reverses CQ resistance in vitro and in vivo) on the disposition of the enlarged liver associated with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria were evaluated." | 9.10 | The effects of chloroquine, amodiaquine and chloroquine plus chlorpheniramine on the disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children. ( Adedeji, AA; Sowunmi, A, 2002) |
| "To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study." | 9.10 | The efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria in Laos. ( Brockman, A; Garcia, M; Gastellu, M; Guthmann, JP; Kasparian, S; Legros, D; Nathan, N; Phetsouvanh, R; Phompida, S, 2002) |
| "In a southern border province of Lao PDR, we compared the efficacy of antimalarial drug combinations in patients aged >or=1 year with uncomplicated Plasmodium falciparum malaria: monotherapy with either mefloquine (MQ), chloroquine (CQ), or sulphadoxine/pyrimethamine (SP) vs." | 9.10 | Therapeutic efficacy of chloroquine plus sulphadoxine/ pyrimethamine compared with monotherapy with either chloroquine or sulphadoxine/pyrimethamine in uncomplicated Plasmodium falciparum malaria in Laos. ( Christophel, EM; Jelinek, T; Jordan, S; Phetsouvanh, R; Phompida, S; Schwöbel, B; Vanisaveth, V; von Sonnenburg, F, 2003) |
| " In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with uncomplicated Plasmodium falciparum malaria who were treated with either chloroquine (CQ) or sulfadoxine/pyrimethamine (SP)." | 9.10 | Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia. ( Castillo, CM; Ferro, BE; Osorio, L, 2002) |
| "In a randomized controlled trial, chloroquine monotherapy was compared with the combination of artesunate and chloroquine for treating uncomplicated Plasmodium falciparum malaria in 536 Gambian children." | 9.10 | The addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children delays, but does not prevent treatment failure. ( Coleman, R; Drakeley, CJ; Jawara, M; Milligan, P; Obisike, U; Pinder, M; Sutherland, CJ; Targett, GA; Walraven, G, 2003) |
| "We evaluated the in vivo responses to chloroquine (CQ), the first line antimalarial, and to sulfadoxine-pyrimethamine (SP), the most readily available and affordable alternative treatment, in children under 5 with acute uncomplicated Plasmodium falciparum malaria in seven sites of Democratic Republic of Congo (DRC) between May 2000 and November 2001, using the standard 14-day WHO protocol." | 9.10 | Assessing the efficacy of chloroquine and sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in the Democratic Republic of Congo. ( Kabuya, W; Kazadi, WM; Kebela, BI; Makina, BN; Mantshumba, JC; Ngimbi, NP; Vong, S, 2003) |
| "The in vivo efficacies of the Lao People's Democratic Republic (Laos) nationally recommended antimalarial agents--chloroquine and sulfadoxine-pyrimethamine-were assessed in a randomized, comparative trial that involved 100 patients with uncomplicated Plasmodium falciparum malaria who were followed for 42 days after starting treatment." | 9.10 | Chloroquine versus sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum malaria in Savannakhet Province, Lao People's Democratic Republic: an assessment of national antimalarial drug recommendations. ( Brockman, A; Khanthavong, M; Mayxay, M; Newton, PN; Phetsouvanh, R; Phompida, S; Tiengkham, P; White, NJ, 2003) |
| " In the present study, the efficacies of chloroquine (CQ) or amodiaquine (AQ) in the oral treatment of acute, symptomatic, uncomplicated, Plasmodium falciparum malaria were compared with those of oral treatments with the combination of CQ or AQ with pyrimethamine-sulfadoxine (PS)." | 9.10 | A randomized comparison of chloroquine, amodiaquine and their combination with pyrimethamine-sulfadoxine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Sowunmi, A, 2002) |
| "The efficacy and kinetics of the combination chloroquine plus sulfadoxine-pyrimethamine (CQ + SP), given sequentially and simultaneously, were investigated in 32 patients with acute uncomplicated Plasmodium falciparum malaria in Palawan Island, the Philippines." | 9.10 | Pharmacokinetics of sequential and simultaneous treatment with the combination chloroquine and sulfadoxine-pyrimethamine in acute uncomplicated Plasmodium falciparum malaria in the Philippines. ( Bustos, DG; Diquet, B; Gay, F; Laracas, CJ; Lazaro, JE; Pottier, A; Traore, B, 2002) |
| "To improve upon the efficacy of primaquine prophylaxis for malaria (94%, Plasmodium falciparum malaria; 85%, Plasmodium vivax malaria), we administered chloroquine (300 mg weekly) in combination with primaquine (30 mg daily) to nonimmune Colombian soldiers during 16 weeks of patrol in a region of endemicity and for a further 1 week in base camp." | 9.09 | Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in nonimmune Colombian soldiers. ( Berman, J; Herrera, R; Padilla, J; Rodriquez, M; Sanchez, J; Soto, J; Toledo, J, 1999) |
| "In India, treatment of acute, uncomplicated Plasmodium falciparum malaria is becoming increasingly difficult due to resistance to chloroquine, thus there is a need for new antimalarial drugs." | 9.09 | A randomized, double-blind, parallel-group, comparative safety, and efficacy trial of oral co-artemether versus oral chloroquine in the treatment of acute uncomplicated Plasmodium falciparum malaria in adults in India. ( Bhatt, AD; Chogle, AR; Dalvi, SS; Garg, MR; Gathmann, I; Gogtay, NJ; Kshirsagar, NA; Marathe, SN; Moorthy, NS; Mull, R; Sane, SP; Sorabjee, JS; Tilve, GH, 2000) |
| "Two controlled trials of chloroquine prophylaxis during pregnancy were performed, one in Burkina Faso in 1987, on all pregnant women, and the other in Cameroon in 1992, on primigravidae only." | 9.08 | Effect of chloroquine prophylaxis during pregnancy on maternal haematocrit. ( Barro, D; Breart, G; Carnevale, P; Cot, M; Deloron, P; Etya'Ale, D; Fievet, N; le Hesran, JY; Miailhes, P; Roisin, A, 1998) |
| " Between January and July 1993, 100 patients presenting with symptomatic Plasmodium falciparum malaria were randomised to receive amodiaquine or chloroquine at the dose of 30 mg/kg for 3 days." | 9.07 | [Parasitological and clinical response to amodiaquine versus chloroquine in the treatment of Plasmodium falciparum malaria in children in an endemic area]. ( Assi-Coulibaly, L; Ehouman, A; Kaptué, B; Konan, D; Penali, LK, 1994) |
| "Chloroquine chemotherapy of malaria fever induces severe generalised pruritus in a large proportion of black Africans." | 9.07 | The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria. ( Ajayi, AA; Ajayi, OO; Akinleye, AO; Ijaware, CO; Oyelese, O; Udoh, SJ, 1991) |
| "The development of chloroquine as an antimalarial drug and the subsequent evolution of drug-resistant Plasmodium strains had major impacts on global public health in the 20th century." | 8.81 | Chloroquine-resistant malaria. ( Plowe, CV; Wellems, TE, 2001) |
| "Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever." | 8.81 | Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2001) |
| "Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever." | 8.80 | Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2000) |
| "Artesunate-amodiaquine (ASAQ) and Artemether-lumefantrine (AL) are the recommended treatment for uncomplicated Plasmodium falciparum malaria in Liberia." | 8.12 | Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers. ( Asinya, M; Jeuronlon, MK; Kamara, P; Koko, VS; Kollie, A; Ma, L; Menard, D; Nyansaiye, P; Parwon, S; Pratt, OJ; Ringwald, P; Taweh, F; Tehmeh, L; Vonhm, B; Warsame, M, 2022) |
| " A fixed ratio method based on the SYBR Green I fluorescence-based assay was used to build isobolograms from a combination of cryptolepine with four standard anti-malarial drugs in vitro using the chloroquine sensitive strain 3D7." | 7.85 | In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine. ( Annan, K; Ansah, C; Forkuo, AD; Gyan, B; Mancama, D; Mensah, KB; Theron, A; Wright, CW, 2017) |
| "Faced with intense levels of chloroquine (CQ) resistance in Plasmodium falciparum malaria, Rwanda replaced CQ with amodiaquine (AQ)+sulfadoxine-pyrimethamine (SP) in 2001, and subsequently with artemether-lumefantrine (AL) in 2006, as first-line treatments for uncomplicated malaria." | 7.83 | Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda. ( Grobusch, MP; Hakizimana, E; Kateera, F; Kumar, N; Mens, PF; Mutesa, L; Nsobya, SL; Tukwasibwe, S; van Vugt, M, 2016) |
| "A novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resistant) and NF54 (sensitive) strains of the malaria parasite Plasmodium falciparum." | 7.81 | Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. ( Chibale, K; Egan, TJ; Jurva, U; Masimirembwa, CM; Njoroge, M; Ongarora, DS; Strydom, N; Wicht, K; Wiesner, L; Wittlin, S, 2015) |
| "Of late there have been accounts of therapeutic failure and chloroquine resistance in Plasmodium vivax malaria especially from Southeast Asian regions." | 7.81 | Therapeutic assessment of chloroquine-primaquine combined regimen in adult cohort of Plasmodium vivax malaria from a tertiary care hospital in southwestern India. ( Acharya, RV; Acharya, V; Belle, J; Hande, MH; Kamath, A; Rishikesh, K; Saravu, K; Shastry, AB; Vidyasagar, S, 2015) |
| "Chloroquine (CQ) is officially used for the primary treatment of Plasmodium falciparum malaria in Honduras." | 7.79 | Efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in Honduras. ( Alam, MT; Banegas, EI; Bucheli, ST; Diaz, C; Fontecha, GA; Goldman, I; Mejia Torres, RE; Mendoza, M; Udhayakumar, V; Zambrano, JO, 2013) |
| "Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected." | 7.78 | Lack of evidence for chloroquine-resistant Plasmodium falciparum malaria, Leogane, Haiti. ( Kain, KC; Neuberger, A; Schwartz, E; Zhong, K, 2012) |
| "Between 2002 and 2004, the standardized 28-day protocol recently developed by the World Health Organization was used to explore the efficacy of chloroquine, in the treatment of uncomplicated, Plasmodium falciparum malaria, in five sentinel sites in southern Iran." | 7.73 | Monitoring of the therapeutic efficacy of chloroquine for the treatment of uncomplicated, Plasmodium falciparum malaria in Iran. ( Faraji, L; Keshavarz, H; Nateghpour, M; Raeisi, A; Ranjbar, M; Ringwald, P; Safa, O; Shahbazi, A, 2006) |
| "We developed and evaluated a rapid, real-time polymerase chain reaction (PCR) assay to detect Plasmodium falciparum malaria and chloroquine (CQ)-resistance determinants in returned travelers who are febrile." | 7.73 | Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers. ( Farcas, GA; Kain, KC; Soeller, R; Zahirieh, A; Zhong, K, 2006) |
| "In West Africa, administration of chloroquine chemoprophylaxis during pregnancy is common, but little is known about its impact on Plasmodium falciparum infection during pregnancy." | 7.72 | Failure of a chloroquine chemoprophylaxis program to adequately prevent malaria during pregnancy in Koupéla District, Burkina Faso. ( Diarra, A; Konate, A; Moran, AC; Newman, RD; Parise, ME; Sawadogo, R; Sirima, SB; Yameogo, M, 2003) |
| "The efficacy of chloroquine treatment of uncomplicated Plasmodium falciparum malaria in East Timor was investigated via molecular tools." | 7.71 | Short report: Molecular evaluation of the efficacy of chloroquine treatment of uncomplicated Plasmodium falciparum malaria in East Timor. ( Baker, J; Burns, M; Chen, N; Cheng, Q; Edstein, MD; Ezard, N, 2002) |
| "Chloroquine is a first line drug for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda." | 7.71 | Resistance patterns of Plasmodium falciparum malaria to chloroquine in Kampala, Uganda. ( Freers, J; Mayanja-Kizza, H; Mulindwa, HC, 2002) |
| "To establish the effects of chloroquine on kidney function we monitored renal parameters in age and sex matched control subjects and patients who presented with acute transient fever." | 7.70 | Chloroquine influences renal function in rural Zimbabweans with acute transient fever. ( Munjeri, O; Musabayane, CT; Musvibe, A; Osim, EE; Wenyika, J, 1999) |
| " In a cohort of pregnant women enrolled at first antenatal clinic visit in rural Malawi, we evaluated reported fever, determined parasitemia, and placed the women on antimalarial regimens containing chloroquine (CQ) or mefloquine (MQ)." | 7.69 | Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine. ( Breman, JG; Heymann, DL; Khoromana, CO; Slutsker, L; Steketee, RW; Wirima, JJ, 1996) |
| "The objective of the study was to determine the efficacy of chloroquine in pregnant women with Plasmodium falciparum parasitemia at therapeutic doses of 25 mg/kg body weight divided over 3 days." | 7.69 | Resistance to chloroquine therapy in pregnant women with malaria parasitemia. ( Ojwang, SB; Oyieke, JB; Rukaria-Kaumbutho, RM, 1996) |
| "The antimalarial activity of beta-artemether and beta-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P." | 7.68 | Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. ( Ager, AL; Canfield, CJ; Heiffer, MH; Klayman, DL; Kyle, DE; Milhous, WK; Rossan, RN; Schuster, BG; Shmuklarsky, MJ; Tang, DB, 1993) |
| " Serious adverse events (AEs; all causality) were observed more frequently with MQ compared with AZCQ (four vs one, respectively), though discontinuations for AEs were similar (four vs three, respectively)." | 6.79 | Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults. ( Chandra, R; Dieng, Y; Djimdé, AA; Dunne, MW; Kain, KC; Mugyenyi, P; Mulenga, M; Oduro, AR; Ogutu, B; Robbins, J; Sagara, I; Sarkar, S; Sie, A; Tiono, AB; Wasunna, M, 2014) |
| "Chloroquine treatment led to a decrease in EPO levels in the control subjects but an increase in malaria patients at day 30." | 6.74 | Effects of chloroquine treatment on circulating erythropoietin and inflammatory cytokines in acute Plasmodium falciparum malaria. ( Ballal, A; Jelkmann, W; Rouina, P; Saeed, A, 2009) |
| "Chloroquine was prescribed at 25 mg per kg body weight, and administered over 3 days to patients suffering from uncomplicated malaria." | 6.71 | [In vivo evaluation of chloroquine therapeutic efficacy in uncomplicated Plasmodium falciparum malaria in Central African Republic ine 1997 and 1998]. ( Barrau, K; Bergeri, I; Delmont, J; Madji, N; Namsenmo, A; Ndoyo, J; Zoguéreh, DD, 2003) |
| " The findings indicate that - at least at the dosing regimen used in the present study and among children with acute, uncomplicated, P." | 6.71 | A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Sowunmi, A, 2003) |
| "falciparum malaria were treated with either CQ monotherapy (n=120) or the combination of CQ plus three doses of AS (CQ/AS; n=352)." | 6.71 | Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes. ( Coleman, R; Drakeley, CJ; Jawara, M; Obisike, U; Pinder, M; Sutherland, CJ; Targett, GA; Walraven, G, 2004) |
| "falciparum malaria was compared with that of CQ, each drug being given at 10 mg/kg per day for 3 days (days 0, 1 and 2)." | 6.70 | Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Adedeji, AA; Ayede, AI; Falade, AG; Falade, CO; Happi, TC; Ndikum, VN; Oduola, AM; Sowunmi, A; Sowunmi, CO, 2001) |
| "Atovaquone-proguanil was well tolerated and more effective than chloroquine or chloroquine-sulfadoxine-pyrimethamine for treatment of multidrug-resistant falciparum malaria in the Philippines." | 6.69 | Atovaquone-proguanil compared with chloroquine and chloroquine-sulfadoxine-pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines. ( Bustos, DG; Canete-Miguel, E; Canfield, CJ; Hutchinson, DB, 1999) |
| "falciparum for at least 14 days." | 6.68 | Efficacy of oral and intravenous artesunate in male Tanzanian adults with Plasmodium falciparum malaria and in vitro susceptibility to artemisinin, chloroquine, and mefloquine. ( Alin, MH; Ashton, M; Bjorkman, A; Bwijo, BA; Kihamia, CM; Mtey, GJ; Premji, Z, 1995) |
| "Chloroquine was taken by 278 men (100 mg daily for 6 weeks after their return to France); the other 480 men were given two doses of 1,500 mg halofantrine on the third and on the tenth day after their return to France." | 6.67 | [Efficacy of radical treatment with halofantrine on the prevention of imported Plasmodium falciparum malaria]. ( Baudon, D; Bernard, J; Lantrade, P; Martet, G; Mouliat-Pelat, JP; Picq, JJ; Sarrouy, J; Spiegel, A; Touzé, JE, 1992) |
| " A model-informed strategy based on preclinical data, which incorporates pharmacokinetic-pharmacodynamic (PK-PD) properties with physiologically based pharmacokinetic (PBPK) modeling, is proposed to optimally predict an efficacious human dose and dosage regimen for the treatment of Plasmodium falciparum malaria." | 5.91 | Integrating Pharmacokinetic-Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study. ( Chibale, K; Gibhard, L; Mulubwa, M; Redhi, D, 2023) |
| "Despite extensive use and accumulated evidence of safety, there have been few pharmacokinetic studies from which appropriate chloroquine (CQ) dosing regimens could be developed specifically for pregnant women." | 5.46 | Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling. ( Baiwog, F; Davis, TME; Ilett, KF; Karunajeewa, HA; Kose, K; Mueller, I; Page-Sharp, M; Rogerson, SJ; Salman, S; Siba, PM, 2017) |
| "Chloroquine failure rate was high which was well above the WHO recommended cut off threshold for drug policy change (> 10%), Sulfadoxine- Pyrimethamine can be used in place of Chloroquine as the first line drug in uncomplicated P." | 5.42 | Comparative Study of Effectiveness and Resistance Profile of Chloroquine and Sulfadoxine-Pyrimethamine in Uncomplicated Plasmodium falciparum Malaria in Kolkata. ( Basu, A; Guha, SK; Saha, S, 2015) |
| "Pyronaridine-artesunate was recently strongly recommended in the 2022 update of the WHO Guidelines for the Treatment of Malaria, becoming the newest artemisinin-based combination therapy (ACT) for both uncomplicated Plasmodium falciparum and Plasmodium vivax malaria." | 5.41 | Pyronaridine: a review of its clinical pharmacology in the treatment of malaria. ( Chu, WY; Dorlo, TPC, 2023) |
| "Chloroquine was provided free of charge to all fever cases." | 5.35 | Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India. ( Das, LK; Jambulingam, P; Sadanandane, C, 2008) |
| "Chloroquine treatment mediated oxidative stress in the host and this effect was exacerbated in Plasmodium falciparum infected patients administered with the drug." | 5.32 | Influence of chloroquine treatment and Plasmodium falciparum malaria infection on some enzymatic and non-enzymatic antioxidant defense indices in humans. ( Emerole, GO; Farombi, EO; Shyntum, YY, 2003) |
| "Chloroquine was administered in accordance with the standard 14 day WHO protocol; i." | 5.32 | [Revaluation of chloroquine therapeutic efficacy on children with uncomplicated Plasmodium falciparum malaria in eastern Ivory Coast (1999-2002)]. ( Adou, SJ; Adoubryn, KD; Assoumou, A; Kouabenan, A; Kouakou, KA; N'guettia, KS; Ouhon, J; Yapo, CG, 2004) |
| "Chloroquine was thus an ineffective therapy for P." | 5.31 | Chloroquine or sulfadoxine-pyrimethamine for the treatment of uncomplicated, Plasmodium falciparum malaria during an epidemic in Central Java, Indonesia. ( Baird, JK; Bangs, MJ; Barcus, MJ; Basuki, W; Edstein, MD; Lacy, MD; Laksana, B; Maguire, JD; Marwoto, H; Masbar, S; Sismadi, P; Susanti, I; Tjokrosonto, S; Wiady, I, 2002) |
| "He had a single grand mal seizure 37 days following retreatment with quinine intravenously, which resulted in rapid clearance of fever and parasitemia, in addition to mefloquine." | 5.29 | [A case of mefloquine-resistant Plasmodium falciparum malaria with convulsion after antimalarial treatment]. ( Aoki, M; Kamei, K; Miyashita, T; Nishiya, H; Ohyatsu, I; Ono, Y; Shibuya, T; Sugiyama, H; Tokumura, Y; Yamaguchi, M, 1994) |
| "Treatment failure of chloroquine in standard dosage (25 mg/kg)." | 5.29 | Risk factors of chloroquine resistance in Plasmodium falciparum malaria. ( Cowdrey, D; Hess, FI; Iannuzzi, A; Leafasia, J; Löscher, T; Nothdurft, HD; Rieckmann, KH; Von Sonnenburg, F, 1996) |
| " A dosage of chloroquine base (25 mg/kg of body weight) was given to women over a 3-day period, followed by 5 mg/kg doses administered weekly for 4 weeks." | 5.28 | Malaria and pregnancy in Cameroonian women. Effect of pregnancy on Plasmodium falciparum parasitemia and the response to chloroquine. ( Campbell, CC; James, MA; Mvondo, JL, 1992) |
| "A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries." | 5.22 | Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review. ( Bwire, GM; Chamani, AT; Mutagonda, RF; Mwakyandile, T; Njiro, BJ; Sabas, D, 2022) |
| "The World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in African regions with moderate to high malaria transmission." | 5.22 | Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial. ( Ayoub, A; Duparc, S; Kamiza, S; Kimani, J; Orrico, R; Phiri, K; Robbins, J; Rojo, R; Vandenbroucke, P, 2016) |
| "This was an open-label, non-comparative study (NCT01103713) in 5 countries in East and sub-Saharan Africa (Benin, Kenya, Malawi, Tanzania, and Uganda) to assess parasitological response and drug concentrations of a single, 3-day course of four tablets of a fixed-dose combination of azithromycin-chloroquine (AZCQ) 250/155 mg given during the second or third trimester to women with asymptomatic Plasmodium falciparum parasitemia in their first or second pregnancy." | 5.22 | Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. ( Ayoub, A; Duparc, S; Kimani, J; Mtove, GA; Phiri, K; Robbins, J; Rojo, R; Vandenbroucke, P; Zhao, Q, 2016) |
| "In 2008, artemether-lumefantrine was introduced in Guinea-Bissau, West Africa, but quinine has also been commonly prescribed for the treatment of uncomplicated Plasmodium falciparum malaria." | 5.20 | Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012. ( Jovel, IT; Kofoed, PE; Rodrigues, A; Rombo, L; Ursing, J, 2015) |
| "Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ) irrespective of age." | 5.19 | Chloroquine is grossly under dosed in young children with malaria: implications for drug resistance. ( Bergqvist, Y; Blessborn, D; Eksborg, S; Kofoed, PE; Rodrigues, A; Rombo, L; Ursing, J, 2014) |
| "In India, till recently, Chloroquine was used as first-line therapy in areas with Chloroquine sensitive Plasmodium falciparum malaria cases." | 5.15 | Efficacy of chloroquine and sulphadoxine-pyrimethamine either alone or in combination before introduction of ACT as first-line therapy in uncomplicated Plasmodium falciparum malaria in Jalpaiguri District, West Bengal, India. ( Bera, DK; Biswas, A; Das, M; Das, S; Guha, SK; Kundu, PK; Maji, AK; Mullick, S; Ray, K; Roy, D; Saha, P; Sengupta, S, 2011) |
| "In order to determine the pharmacokinetic disposition of chloroquine (CQ) and its active metabolite, desethylchloroquine (DECQ), when administered as intermittent presumptive treatment in pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third trimester of pregnancy and 30 age-matched nonpregnant women were administered three daily doses of 450 mg CQ (8." | 5.14 | Pharmacokinetics of chloroquine and monodesethylchloroquine in pregnancy. ( Baiwog, F; Davis, TM; Gomorrai, S; Ilett, KF; Karunajeewa, HA; Law, I; Mueller, I; Page-Sharp, M; Rogerson, S; Salman, S; Siba, P, 2010) |
| "The weekly chemoprophylaxis of malaria during pregnancy with chloroquine (CQ) has become problematic with the increasing resistance of Plasmodium falciparum to this drug." | 5.14 | Placental malaria and low birth weight in pregnant women living in a rural area of Burkina Faso following the use of three preventive treatment regimens. ( Bougouma, EC; Diarra, A; Konaté, AT; Nébié, I; Ouedraogo, A; Sirima, SB; Tiono, AB, 2009) |
| "5 and 12 yr with clinical and parasitological evidence of Plasmodium falciparum malaria were randomized to receive either artesunate plus cotrimoxazole or artesunate plus chloroquine." | 5.14 | Comparative study of efficacy of artesunate plus cotrimoxazole and artesunate plus chloroquine in the treatment of malaria in Nigerian children: a preliminary report. ( Balogun, ST; Fehintola, FA, 2010) |
| "Amodiaquine (AQ), an effective antimalarial drug for uncomplicated malaria, has been greatly restricted after cases of life-threatening agranulocytosis and hepatic toxicity during prophylactic use." | 5.13 | Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania. ( Akida, JA; Bygbjerg, IC; Chile, MM; Kitua, AY; Lemnge, MM; Lusingu, JP; Makunde, R; Malebo, HM; Massaga, JJ; Rønn, AM; Theander, TG, 2008) |
| "Among 975 primary treatment courses, the cumulative 28-day curative efficacies were 26% and 82% for chloroquine against Plasmodium falciparum malaria and Plasmodium vivax malaria, respectively." | 5.12 | Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. ( Baird, JK; Fryauff, DJ; Maguire, JD; Marwoto, H; Richie, TL, 2006) |
| " We recommend the use of artemisinin-based combination therapy as first-line treatment for uncomplicated Plasmodium falciparum malaria in Koumantou." | 5.12 | Efficacy of chloroquine and sulfadoxine/pyrimethamine for the treatment of uncomplicated falciparum malaria in Koumantou, Mali. ( de Radiguès, X; Diallo, KI; Diallo, M; Djimdé, A; Doumbo, O; Guthmann, JP; Maiga, H; Ngwakum, PA; Sacko, M, 2006) |
| "Amodiaquine alone or in combination with sulphadoxine-pyrimethamine, although associated with minor side-effects, is effective when used to treat malaria in pregnancy." | 5.12 | Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial. ( Browne, E; Bruce, J; Chandramohan, D; Greenwood, B; Randal, A; Tagbor, H, 2006) |
| "To assess the safety of chloroquine (CQ) as prophylaxis against Plasmodium vivax infection during pregnancy." | 5.12 | Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, double-blind, placebo-controlled trial. ( Arunjerdja, R; Greenwood, B; Htway, M; McGready, R; Nosten, F; Paw, MK; Pimanpanarak, M; Viladpai-Nguen, SJ; Villegas, L; White, NJ, 2007) |
| "Few studies have documented the effectiveness in west Africa of intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine (SP) in pregnancy." | 5.12 | A comparison of sulfadoxine-pyrimethamine with chloroquine and pyrimethamine for prevention of malaria in pregnant Nigerian women. ( Madaki, JK; Sagay, AS; Thacher, TD; Tukur, IU, 2007) |
| "Chloroquine should no longer be used to treat children presenting with Plasmodium falciparum malaria in Benin." | 5.12 | Dramatically decreased therapeutic efficacy of chloroquine and sulfadoxine-pyrimethamine, but not mefloquine, in southern Benin. ( Aubouy, A; Bertin, G; Deloron, P; Fievet, N; Kinde-Gazard, D; Kiniffo, R; Kossou, H; Massougbodji, A; Sagbo, JC, 2007) |
| " The purpose was to compare the efficacy of two regimens using chloroquine (CQ) or sulfadoxine-pyrimethamine (SP) during pregnancy and delivery in a village located in an endemic area of Mali." | 5.12 | [Randomized clinical trial of two malaria prophylaxis regimens for pregnant women in Faladie, Mali]. ( Dabo, CA; Diallo, M; Diarra, MA; Doumbo, O; Kayentao, K; Ongoiba, A; Sangho, H; Saye, R; Yattara, O, 2007) |
| "A study of the therapeutic efficacy of combined chloroquine and sulfadoxine-pyrimethamine (SP) for the treatment of uncomplicated Plasmodium falciparum malaria was carried out from June to November 2002, using the standard protocol recommended by the WHO for a low-to-moderate transmission area, in two sentinel sites in Bangladesh: Alikadam Upazilla in Bandarban district and Matiranga Upazilla in Khagrachari district." | 5.11 | Efficacy of combined chloroquine and sulfadoxine-pyrimethamine in uncomplicated Plasmodium falciparum malaria in Bangladesh. ( Bangali, M; Das, S; Rahman, M; Rahman, R; Ringwald, P; Talukder, MR, 2004) |
| "The efficacy of a single dose of 45 mg primaquine, as a gametocytocidal agent, was assessed in Mumbai, India, among adults with uncomplicated or severe Plasmodium falciparum malaria." | 5.11 | A prospective study evaluating the efficacy of a single, 45-mg dose of primaquine, as a gametocytocidal agent, in patients with Plasmodium falciparum malaria in Mumbai, India. ( Aigal, U; Chogle, AR; Dalvi, SS; Gogtay, NJ; Kamtekar, KD; Karnad, DR; Kshirsagar, NA, 2004) |
| "In November-December 2002, 98 patients presented at the Elhara Eloula health centre, in the New Halfa area of eastern Sudan, with Plasmodium falciparum malaria that had failed to respond to chloroquine treatment." | 5.11 | Low-dose quinine is effective in the treatment of chloroquine-resistant Plasmodium falciparum malaria in eastern Sudan. ( Adam, I; Aelbasit, IA; Elbashir, MI; Ibrahim, MH; Kheir, MM; Naser, A, 2004) |
| "Recent clinical trials in the Lao People's Democratic Republic have demonstrated that chloroquine and sulfadoxine-pyrimethamine, which are national malaria treatment policy, are no longer effective in the treatment of uncomplicated Plasmodium falciparum malaria." | 5.11 | Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic. ( Annerberg, A; Barends, M; Keola, S; Khanthavong, M; Lindegårdh, N; Mayxay, M; Newton, PN; Phetsouvanh, R; Phompida, S; Pongvongsa, T; White, NJ; Yapom, R, 2004) |
| "The study examined the efficacy of chloroquine (CQ), amodiaquine (AQ) and sulphadoxine-pyrimethamine (SP) for the treatment of uncomplicated Plasmodium falciparum malaria in Ghana." | 5.11 | A randomized comparative study of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Ghana. ( Amankwa, J; Ansah, NA; Ansah, P; Anto, F; Anyorigiya, T; Atuguba, F; Hodgson, A; Mumuni, G; Oduro, AR, 2005) |
| " The efficacy of chloroquine was tested in India among 91 subjects and of sulfadoxine-pyrimethamine in Nepal among 107 subjects with laboratory-confirmed Plasmodium falciparum malaria." | 5.11 | Therapeutic efficacy of antimalarial drugs along the eastern Indo-Nepal border: a cross-border collaborative study. ( Adak, T; Ansari, MA; Bannerjee, S; Bista, MB; Chand, PB; Jha, J; Pandey, S; Shahi, B; Valecha, N; Wijeyaratne, PM, 2005) |
| "Both northern and southern Sudan are deploying artemisinin-based combinations against uncomplicated Plasmodium falciparum malaria (artesunate+sulfadoxine-pyrimethamine [AS+SP] in the north, artesunate+amodiaquine [AS+AQ] in the south)." | 5.11 | Malaria in the Nuba Mountains of Sudan: baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine-pyrimethamine and artesunate plus amodiaquine combinations. ( Atkin, S; Checchi, F; Ford, N; Hamour, S; Hook, C; Keus, K; Melaku, Y; Montgomery, J; Wambugu, J, 2005) |
| " The authors recommend that the treatment to be used in Abie must be firstly amodiaquine followed by sulfadoxine-pyrimethamine in cases where there is persistent asymptomatic parasitemia." | 5.11 | [Evaluation of the therapeutic efficacy of amodiaquine versus chloroquine in the treatment of uncomplicated malaria in Abie, Côte-d'Ivoire]. ( Adjetey, TA; Affoumou, GB; Barro-Kiki, P; Kone, M; Loukou, DD; Menan, EI; Nebavi, NG; Yavo, W, 2005) |
| "At a public hospital in Georgetown, Guyana, 44 patients seeking treatment for symptomatic, slide-confirmed malaria were given standard chloroquine (CQ) therapy and followed for 28 days." | 5.10 | Chloroquine for the treatment of uncomplicated malaria in Guyana. ( Baird, JK; Bravet, PP; Carucci, D; Ferrel, M; Hoffman, SL; Martin, GJ; Prout, TM; Rawlins, S; Tamminga, CL; Tiwari, T; Tjaden, J, 2002) |
| " Children with fever and >or=2000 asexual forms of Plasmodium falciparum/ micro L in a thick blood smear received chloroquine and were randomly assigned to receive zinc (20 mg/d for infants, 40 mg/d for older children) or placebo for 4 d." | 5.10 | Effect of zinc on the treatment of Plasmodium falciparum malaria in children: a randomized controlled trial. ( , 2002) |
| "The effects of chloroquine (CQ), amodiaquine (AQ) and CQ plus chlorpheniramine (a histamine H(1) antagonist that reverses CQ resistance in vitro and in vivo) on the disposition of the enlarged liver associated with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria were evaluated." | 5.10 | The effects of chloroquine, amodiaquine and chloroquine plus chlorpheniramine on the disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children. ( Adedeji, AA; Sowunmi, A, 2002) |
| "To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study." | 5.10 | The efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria in Laos. ( Brockman, A; Garcia, M; Gastellu, M; Guthmann, JP; Kasparian, S; Legros, D; Nathan, N; Phetsouvanh, R; Phompida, S, 2002) |
| "In a southern border province of Lao PDR, we compared the efficacy of antimalarial drug combinations in patients aged >or=1 year with uncomplicated Plasmodium falciparum malaria: monotherapy with either mefloquine (MQ), chloroquine (CQ), or sulphadoxine/pyrimethamine (SP) vs." | 5.10 | Therapeutic efficacy of chloroquine plus sulphadoxine/ pyrimethamine compared with monotherapy with either chloroquine or sulphadoxine/pyrimethamine in uncomplicated Plasmodium falciparum malaria in Laos. ( Christophel, EM; Jelinek, T; Jordan, S; Phetsouvanh, R; Phompida, S; Schwöbel, B; Vanisaveth, V; von Sonnenburg, F, 2003) |
| " In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with uncomplicated Plasmodium falciparum malaria who were treated with either chloroquine (CQ) or sulfadoxine/pyrimethamine (SP)." | 5.10 | Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia. ( Castillo, CM; Ferro, BE; Osorio, L, 2002) |
| "In a randomized controlled trial, chloroquine monotherapy was compared with the combination of artesunate and chloroquine for treating uncomplicated Plasmodium falciparum malaria in 536 Gambian children." | 5.10 | The addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children delays, but does not prevent treatment failure. ( Coleman, R; Drakeley, CJ; Jawara, M; Milligan, P; Obisike, U; Pinder, M; Sutherland, CJ; Targett, GA; Walraven, G, 2003) |
| "We evaluated gametocyte carriage and intensities of gametocytaemia in 710 children presenting with acute, symptomatic, uncomplicated Plasmodium falciparum malaria who were treated with various antimalarial drug regimens: chloroquine (CQ); chloroquine plus chlorpheniramine, a histamine H1 receptor antagonist that reverses CQ resistance in P." | 5.10 | Plasmodium falciparum gametocytaemia in Nigerian children: before, during and after treatment with antimalarial drugs. ( Fateye, BA; Sowunmi, A, 2003) |
| "We evaluated the in vivo responses to chloroquine (CQ), the first line antimalarial, and to sulfadoxine-pyrimethamine (SP), the most readily available and affordable alternative treatment, in children under 5 with acute uncomplicated Plasmodium falciparum malaria in seven sites of Democratic Republic of Congo (DRC) between May 2000 and November 2001, using the standard 14-day WHO protocol." | 5.10 | Assessing the efficacy of chloroquine and sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in the Democratic Republic of Congo. ( Kabuya, W; Kazadi, WM; Kebela, BI; Makina, BN; Mantshumba, JC; Ngimbi, NP; Vong, S, 2003) |
| "The in vivo efficacies of the Lao People's Democratic Republic (Laos) nationally recommended antimalarial agents--chloroquine and sulfadoxine-pyrimethamine-were assessed in a randomized, comparative trial that involved 100 patients with uncomplicated Plasmodium falciparum malaria who were followed for 42 days after starting treatment." | 5.10 | Chloroquine versus sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum malaria in Savannakhet Province, Lao People's Democratic Republic: an assessment of national antimalarial drug recommendations. ( Brockman, A; Khanthavong, M; Mayxay, M; Newton, PN; Phetsouvanh, R; Phompida, S; Tiengkham, P; White, NJ, 2003) |
| "The antimalarial activity of artemether following oral or intramuscular administration in the plasma of 15 adults with acute uncomplicated Plasmodium falciparum malaria was measured by bioassay." | 5.10 | Artemether bioavailability after oral or intramuscular administration in uncomplicated falciparum malaria. ( Newton, PN; Pukrittayakamee, S; Rasameesoraj, M; Silamut, K; Siriyanonda, D; Suputtamongkol, Y; Teja-Isavadharm, P; White, NJ, 2003) |
| " In the present study, the efficacies of chloroquine (CQ) or amodiaquine (AQ) in the oral treatment of acute, symptomatic, uncomplicated, Plasmodium falciparum malaria were compared with those of oral treatments with the combination of CQ or AQ with pyrimethamine-sulfadoxine (PS)." | 5.10 | A randomized comparison of chloroquine, amodiaquine and their combination with pyrimethamine-sulfadoxine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Sowunmi, A, 2002) |
| "The efficacy and kinetics of the combination chloroquine plus sulfadoxine-pyrimethamine (CQ + SP), given sequentially and simultaneously, were investigated in 32 patients with acute uncomplicated Plasmodium falciparum malaria in Palawan Island, the Philippines." | 5.10 | Pharmacokinetics of sequential and simultaneous treatment with the combination chloroquine and sulfadoxine-pyrimethamine in acute uncomplicated Plasmodium falciparum malaria in the Philippines. ( Bustos, DG; Diquet, B; Gay, F; Laracas, CJ; Lazaro, JE; Pottier, A; Traore, B, 2002) |
| "To improve upon the efficacy of primaquine prophylaxis for malaria (94%, Plasmodium falciparum malaria; 85%, Plasmodium vivax malaria), we administered chloroquine (300 mg weekly) in combination with primaquine (30 mg daily) to nonimmune Colombian soldiers during 16 weeks of patrol in a region of endemicity and for a further 1 week in base camp." | 5.09 | Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in nonimmune Colombian soldiers. ( Berman, J; Herrera, R; Padilla, J; Rodriquez, M; Sanchez, J; Soto, J; Toledo, J, 1999) |
| "In India, treatment of acute, uncomplicated Plasmodium falciparum malaria is becoming increasingly difficult due to resistance to chloroquine, thus there is a need for new antimalarial drugs." | 5.09 | A randomized, double-blind, parallel-group, comparative safety, and efficacy trial of oral co-artemether versus oral chloroquine in the treatment of acute uncomplicated Plasmodium falciparum malaria in adults in India. ( Bhatt, AD; Chogle, AR; Dalvi, SS; Garg, MR; Gathmann, I; Gogtay, NJ; Kshirsagar, NA; Marathe, SN; Moorthy, NS; Mull, R; Sane, SP; Sorabjee, JS; Tilve, GH, 2000) |
| " To examine the effect of such therapy on transmission, Gambian children with Plasmodium falciparum malaria were treated with standard regimens of chloroquine or pyrimethamine-sulfadoxine alone or in combination with 1 or 3 doses of artesunate." | 5.09 | Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae. ( Coleman, R; Deen, J; Doherty, T; Drakeley, C; Jawara, M; Milligan, P; Pinder, M; Sutherland, C; Targett, G; von Seidlein, L; Walraven, G, 2001) |
| "The present in vivo study evaluates the potential use of ketotifen, a tricyclic antihistaminic drug, in treatment of Sudanese patients with uncomplicated Plasmodium falciparum malaria (19-38 years)." | 5.09 | Ketotifen in treatment of uncomplicated falciparum malaria. ( Elhag, ER; Ibrahim, AM; Mustafa, SE, 2000) |
| "In a randomized trial, a high dosage chloroquine monotherapy (45 mg/kg over 3 days) was compared with combination regimens of sulfadoxine/pyrimethamine and chloroquine/clindamycin for treating Gabonese school children with Plasmodium falciparum malaria." | 5.08 | Sulfadoxine/pyrimethamine or chloroquine/clindamycin treatment of Gabonese school children infected with chloroquine resistant malaria. ( Bienzle, U; Graninger, W; Kremsner, PG; Metzger, W; Mordmüller, B, 1995) |
| "Ninety-two children with complicated, but not cerebral, Plasmodium falciparum malaria, aged 1-9 years, were recruited between August 1992 and December 1994 to an open, randomized trial of parenteral chloroquine (28), pyrimethamine-sulfadoxine (P-S) (36) and quinine (28)." | 5.08 | A comparative study of parenteral chloroquine, quinine and pyrimethamine-sulfadoxine in the treatment of Gambian children with complicated, non-cerebral malaria. ( Corrah, PT; de Veer, GE; Giadom, B; Greenwood, BM; Jaffar, S; van Hensbroek, MB, 1996) |
| "Sixty-nine children aged between 6 and 60 months with parasitologically proven Plasmodium falciparum malaria were treated with chloroquine (2." | 5.08 | Chloroquine-resistant Plasmodium falciparum among children in Calabar, south eastern Nigeria. ( Alaribe, AA; Antia-Obong, OE; Bassy, A; Etim, BV; Young, MU, 1997) |
| "Two controlled trials of chloroquine prophylaxis during pregnancy were performed, one in Burkina Faso in 1987, on all pregnant women, and the other in Cameroon in 1992, on primigravidae only." | 5.08 | Effect of chloroquine prophylaxis during pregnancy on maternal haematocrit. ( Barro, D; Breart, G; Carnevale, P; Cot, M; Deloron, P; Etya'Ale, D; Fievet, N; le Hesran, JY; Miailhes, P; Roisin, A, 1998) |
| "A randomized, open trial involving 260 Tanzanian children, aged 1-5 years, with acute Plasmodium falciparum malaria was conducted to evaluate the efficacy of the combination antimalarial CGP 56697 (artemether and benflumetol), and to compare it with chloroquine, the standard drug used for malaria treatment in the Kilombero area." | 5.08 | Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged 1-5 years. ( Abdulla, S; Beck, HP; Gathmann, I; Hatz, C; Kibatala, P; Mull, R; Royce, C; Schellenberg, D; Tanner, M, 1998) |
| " Between January and July 1993, 100 patients presenting with symptomatic Plasmodium falciparum malaria were randomised to receive amodiaquine or chloroquine at the dose of 30 mg/kg for 3 days." | 5.07 | [Parasitological and clinical response to amodiaquine versus chloroquine in the treatment of Plasmodium falciparum malaria in children in an endemic area]. ( Assi-Coulibaly, L; Ehouman, A; Kaptué, B; Konan, D; Penali, LK, 1994) |
| "To define an effective and deliverable antimalarial regimen for use during pregnancy, pregnant women at highest risk of malaria (those in their first or second pregnancy) in an area of Malawi with high transmission of chloroquine (CQ)-resistant Plasmodium falciparum were placed on CQ and/or sulfadoxine-pyrimethamine (SP)." | 5.07 | The efficacy of antimalarial regimens containing sulfadoxine-pyrimethamine and/or chloroquine in preventing peripheral and placental Plasmodium falciparum infection among pregnant women in Malawi. ( Chitsulo, L; Kazembe, P; Macheso, A; Schultz, LJ; Steketee, RW; Wirima, JJ, 1994) |
| "The spread of chloroquine-resistant Plasmodium falciparum malaria has led to increased use of mefloquine prophylaxis by US Peace Corps volunteers in sub-Saharan Africa." | 5.07 | Long-term malaria prophylaxis with weekly mefloquine. ( Bernard, KW; Campbell, CC; Eng, T; Hightower, AW; Lobel, HO; Miani, M, 1993) |
| "In October 1988, a project was implemented for assessing the malaria chemoprophylactic efficacy of weekly chloroquine (CQ) and daily proguanil (PROG) during pregnancy in Muheza-Tanzania." | 5.07 | Malaria in infants whose mothers received chemoprophylaxis: response to amodiaquine therapy. ( de Geus, A; Malle, LN; Mutabingwa, TK; Wernsdorfer, WH, 1992) |
| "In-vivo and in-vitro studies to determine the sensitivity of Plasmodium falciparum malaria to chloroquine and amodiaquine were conducted in 4 districts of Western Kenya over a 2-year-period." | 5.07 | Sensitivity of falciparum malaria to chloroquine and amodiaquine in four districts of western Kenya (1985-1987). ( Adoyo, A; Boriga, DA; Kariuki, D; Koech, DK; Magiri, C; Oloo, AJ; Were, JB, 1991) |
| "Chloroquine chemotherapy of malaria fever induces severe generalised pruritus in a large proportion of black Africans." | 5.07 | The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria. ( Ajayi, AA; Ajayi, OO; Akinleye, AO; Ijaware, CO; Oyelese, O; Udoh, SJ, 1991) |
| " Chemopreventive strategies have been increasingly deployed in Africa, notably intermittent sulfadoxine-pyrimethamine treatment in pregnancy, and monthly amodiaquine-sulfadoxine-pyrimethamine during the rainy season months in children aged between 3 months and 5 years across the sub-Sahel." | 4.90 | Malaria. ( Dondorp, AM; Faiz, MA; Hien, TT; Mokuolu, OA; Pukrittayakamee, S; White, NJ, 2014) |
| "Plasmodium falciparum resistance to chloroquine and sulphadoxine-pyrimethamine has led to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of treatment against malaria." | 4.85 | Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. ( Eastman, RT; Fidock, DA, 2009) |
| "To assess the relationship between the genetic and phenotypic factors linked to the cytochrome P-450 enzyme system and the response to the antimalarial drugs chloroquine, amodiaquine, mefloquine, and proguanil, as well as to determine how certain biological and social factors of the host influence the behavior of this enzymatic complex." | 4.83 | [Cytochrome P-450 and the response to antimalarial drugs]. ( Carmona-Fonseca, J; Guzmán, V, 2006) |
| "To compare amodiaquine with chloroquine or sulfadoxine-pyrimethamine for treating uncomplicated Plasmodium falciparum malaria." | 4.82 | Amodiaquine for treating malaria. ( Mussano, P; Olliaro, P, 2003) |
| "Drug resistance is one of the major factors contributing to the resurgence of malaria, especially resistance to the most affordable drugs such as chloroquine and Fansidar, a combination drug of pyrimethamine and sulfadoxine." | 4.82 | Genetic and biochemical aspects of drug resistance in malaria parasites. ( Hayton, K; Su, XZ, 2004) |
| "The development of chloroquine as an antimalarial drug and the subsequent evolution of drug-resistant Plasmodium strains had major impacts on global public health in the 20th century." | 4.81 | Chloroquine-resistant malaria. ( Plowe, CV; Wellems, TE, 2001) |
| "Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever." | 4.81 | Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2001) |
| "Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever." | 4.80 | Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria. ( McIntosh, HM, 2000) |
| "Chloroquine-resistant Plasmodium falciparum malaria is an emerging problem in the West African subregion." | 4.78 | Drug resistance in malaria: a review of the west African situation. ( Adubofour, KO, 1992) |
| "The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are still commonly used for malaria treatment, either alone (CQ) or in combination with artemisinin derivatives." | 4.31 | Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities. ( Basilico, N; D'Alessandro, S; Dondio, G; Misiano, P; Nasser, S; Nosten, F; Parapini, S; Rénia, L; Romeo, S; Russell, BM; Sparatore, A; Suwanarusk, R; Taramelli, D; Vivas, L; Yardley, V, 2023) |
| "Pfcrt gene has been associated with chloroquine resistance and the pfmdr1 gene can alter malaria parasite susceptibility to lumefantrine, mefloquine, and chloroquine." | 4.31 | Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia. ( Amambua-Ngwa, A; Dugassa, S; Golassa, L; Jawara, A; Oboh, M; Oriero, E; Tadele, G, 2023) |
| "The online and command line versions of Malaria-Profiler detect ~ 250 markers from genome sequences covering Plasmodium speciation, likely geographical source, and resistance to chloroquine, sulfadoxine-pyrimethamine (SP), and other anti-malarial drugs for P." | 4.31 | Rapid profiling of Plasmodium parasites from genome sequences to assist malaria control. ( Beshir, KB; Binh, NTH; Bousema, T; Campino, S; Clark, TG; Di Santi, SM; Dombrowski, JG; Gitaka, J; Manko, E; Ngoc, NTH; Nolder, D; Phelan, JE; Sutherland, CJ; Thieu, NQ; Thorpe, J; Turkiewicz, A; van de Vegte-Bolmer, M; Vanheer, LN, 2023) |
| "Artesunate-amodiaquine (ASAQ) and Artemether-lumefantrine (AL) are the recommended treatment for uncomplicated Plasmodium falciparum malaria in Liberia." | 4.12 | Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers. ( Asinya, M; Jeuronlon, MK; Kamara, P; Koko, VS; Kollie, A; Ma, L; Menard, D; Nyansaiye, P; Parwon, S; Pratt, OJ; Ringwald, P; Taweh, F; Tehmeh, L; Vonhm, B; Warsame, M, 2022) |
| "The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic development of the human malaria parasite Plasmodium falciparum." | 4.12 | The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum. ( Barrett, MP; Lanzer, M; Mandel, L; Manson, EDT; Moliner Cubel, S; Sanchez, CP; Weidt, SK, 2022) |
| " Chloroquine (CQ) is a low-cost antimalarial used worldwide for the treatment of Plasmodium vivax malaria." | 4.12 | Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues. ( Annunciato, Y; Caroline C Aguiar, A; Cortopassi, WA; Dos Santos Ferreira, A; Garcia Teles, CB; Gazarini, ML; Guido, RVC; Gunderson, E; Jacobson, MP; Krettli, AU; Meneghetti, MR; Pereira, DB; Pimentel, AS; Ramamoorthi, R; Silva, AES, 2022) |
| " Artesunate plus sulfadoxine-pyrimethamine (AS + SP) has been introduced since 2010 as first-line treatment for uncomplicated Plasmodium falciparum malaria." | 4.12 | Molecular surveillance of anti-malarial drug resistance genes in Plasmodium falciparum isolates in Odisha, India. ( Bal, M; Das, A; Khan, N; Pati, S; Rana, R; Ranjit, M; Sandeepta, S, 2022) |
| "In 2002, Zambia withdrew chloroquine as first-line treatment for Plasmodium falciparum malaria due to increased treatment failure and worldwide spread of chloroquine resistance." | 4.02 | Decreased prevalence of the Plasmodium falciparum Pfcrt K76T and Pfmdr1 and N86Y mutations post-chloroquine treatment withdrawal in Katete District, Eastern Zambia. ( Chipeta, J; Ciubotariu, II; Hamainza, B; Hawela, MB; Mharakurwa, S; Mulenga, MC; Sitali, L, 2021) |
| " Quantification of Free Ferriprotoporphyrin IX Heme and Hemozoin for Artemisinin Sensitive versus Delayed Clearance Phenotype Plasmodium falciparum Malarial Parasites." | 3.88 | Dihydroartemisinin-Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and the Relationship to Emerging Artemisinin Resistance. ( Goggins, E; Heller, LE; Roepe, PD, 2018) |
| "Epoxyazadiradione (1), a major compound derived from Neem oil, showed modest anti-plasmodial activity against CQ-resistant and CQ-sensitive strains of the most virulent human malaria parasite P." | 3.85 | Synthesis and evaluation of anti-plasmodial and cytotoxic activities of epoxyazadiradione derivatives. ( Allanki, AD; Ashok Yadav, P; Jain, N; Pavan Kumar, C; Sijwali, PS; Siva, B; Suresh Babu, K; Veerabhadra Rao, A, 2017) |
| " A fixed ratio method based on the SYBR Green I fluorescence-based assay was used to build isobolograms from a combination of cryptolepine with four standard anti-malarial drugs in vitro using the chloroquine sensitive strain 3D7." | 3.85 | In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine. ( Annan, K; Ansah, C; Forkuo, AD; Gyan, B; Mancama, D; Mensah, KB; Theron, A; Wright, CW, 2017) |
| "A 3-day artesunate-mefloquine combination therapy has been using as first-line treatment for acute uncomplicated Plasmodium falciparum malaria in Thailand since 1995 on the background of mefloquine resistance." | 3.85 | In vitro sensitivity of antimalarial drugs and correlation with clinico-parasitological response following treatment with a 3-day artesunate-mefloquine combination in patients with falciparum malaria along the Thai-Myanmar border. ( Muhamad, P; Na-Bangchang, K; Phompradit, P; Thiengsusuk, A, 2017) |
| "To understand the endemic situation of chloroquine-resistant falciparum malaria in Yunnan Province by analyzing the polymorphism of the 72-76 amino-acid coding sequence within exon 2 region of Plasmodium falciparum chloroquine resistant transporter (Pfcrt) gene （referred to as the 72-76 coding region） in malaria patients." | 3.83 | [Polymorphism of 72-76 Coding Sequence within Exon 2 Region of Pfcrt in Yunnan Province]. ( Chen, MN; Deng, Y; Dong, Y; Mao, XH; Xu, YC; Zhu, YJ, 2016) |
| "In 1993, Malawi changed its first-line anti-malarial treatment for uncomplicated malaria from chloroquine to sulfadoxine-pyrimethamine (SP), and in 2007, it changed from SP to lumefantrine-artemether." | 3.83 | Malaria research and its influence on anti-malarial drug policy in Malawi: a case study. ( de Jager, C; Hongoro, C; Longwe, H; Mutero, CM; Mwendera, C; Phiri, K, 2016) |
| "Faced with intense levels of chloroquine (CQ) resistance in Plasmodium falciparum malaria, Rwanda replaced CQ with amodiaquine (AQ)+sulfadoxine-pyrimethamine (SP) in 2001, and subsequently with artemether-lumefantrine (AL) in 2006, as first-line treatments for uncomplicated malaria." | 3.83 | Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda. ( Grobusch, MP; Hakizimana, E; Kateera, F; Kumar, N; Mens, PF; Mutesa, L; Nsobya, SL; Tukwasibwe, S; van Vugt, M, 2016) |
| "Chloroquine (CQ) has been used as first line malaria therapeutic drug for decades." | 3.81 | Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives. ( Caridha, D; Gerena, L; Korotchenko, V; Kreishman-Deitrick, M; Li, Q; Lin, AJ; Sathunuru, R; Smith, PL, 2015) |
| "A novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resistant) and NF54 (sensitive) strains of the malaria parasite Plasmodium falciparum." | 3.81 | Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. ( Chibale, K; Egan, TJ; Jurva, U; Masimirembwa, CM; Njoroge, M; Ongarora, DS; Strydom, N; Wicht, K; Wiesner, L; Wittlin, S, 2015) |
| "Cambodia's first-line artemisinin combination therapy, dihydroartemisinin-piperaquine (DHA-PPQ), is no longer sufficiently curative against multidrug-resistant Plasmodium falciparum malaria at some Thai-Cambodian border regions." | 3.81 | Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance. ( Buathong, N; Chanarat, N; Chann, S; Chaorattanakawee, S; Chuor, CM; Gosi, P; Heng, TK; Jacob, C; Kong, N; Kuntawunginn, W; Lanteri, CA; Lin, JT; Lon, C; Plowe, C; Prom, S; Saingam, P; Saunders, DL; Se, Y; Sea, D; Sriwichai, S; Sundrakes, S; Takala-Harrison, S; Tangthongchaiwiriya, K; Teja-Isavadharm, P; Tyner, SD; Yingyuen, K; Yom, Y, 2015) |
| "Of late there have been accounts of therapeutic failure and chloroquine resistance in Plasmodium vivax malaria especially from Southeast Asian regions." | 3.81 | Therapeutic assessment of chloroquine-primaquine combined regimen in adult cohort of Plasmodium vivax malaria from a tertiary care hospital in southwestern India. ( Acharya, RV; Acharya, V; Belle, J; Hande, MH; Kamath, A; Rishikesh, K; Saravu, K; Shastry, AB; Vidyasagar, S, 2015) |
| "Chloroquine (CQ) is used as a first-line therapy for the treatment of Plasmodium falciparum malaria in Nicaragua." | 3.80 | Molecular analysis of chloroquine and sulfadoxine-pyrimethamine resistance-associated alleles in Plasmodium falciparum isolates from Nicaragua. ( Macedo De Oliveira, A; Rodriguez, B; Soto, AM; Sridaran, S; Udhayakumar, V, 2014) |
| "Chloroquine resistance in Plasmodium falciparum malaria has been associated with pfcrt 76T (chloroquine resistance transporter gene) and pfmdr1 86Y (multidrug resistance gene 1) alleles." | 3.80 | Single nucleotide polymorphisms in Plasmodium falciparum V type H(+) pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms. ( Björkman, A; Ferreira, PE; Jovel, IT; Kaneko, A; Malmberg, M; Mårtensson, A; Murillo, C; Nosten, F; Ursing, J; Veiga, MI; Zakeri, S, 2014) |
| "Chloroquine (CQ) is officially used for the primary treatment of Plasmodium falciparum malaria in Honduras." | 3.79 | Efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in Honduras. ( Alam, MT; Banegas, EI; Bucheli, ST; Diaz, C; Fontecha, GA; Goldman, I; Mejia Torres, RE; Mendoza, M; Udhayakumar, V; Zambrano, JO, 2013) |
| "Although resistance to chloroquine (CQ) has relegated it from modern chemotherapeutic strategies to treat Plasmodium falciparum malaria, new evidence suggests that higher doses of the drug may exert a different killing mechanism and offers this drug a new lease of life." | 3.78 | Can we teach an old drug new tricks? ( Ch'ng, JH; Nosten, F; Renia, L; Tan, KS, 2012) |
| "Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected." | 3.78 | Lack of evidence for chloroquine-resistant Plasmodium falciparum malaria, Leogane, Haiti. ( Kain, KC; Neuberger, A; Schwartz, E; Zhong, K, 2012) |
| "Quinine is still recommended as an effective therapy for severe cases of Plasmodium falciparum malaria, but the parasite has developed resistance to the drug in some cases." | 3.77 | In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo. ( Amalvict, R; Baret, E; Bogreau, H; Briolant, S; Castello, J; Hovette, P; Pelleau, S; Pradines, B; Rogier, C; Zettor, A, 2011) |
| "A combination of chloroquine (CQ) and primaquine (PQ) had been used as the first-line treatment of uncomplicated Plasmodium falciparum malaria in Rangamati, Bangladesh until the end of 2004." | 3.77 | Efficacy of chloroquine plus primaquine treatment and pfcrt mutation in uncomplicated falciparum malaria patients in Rangamati, Bangladesh. ( Arita, N; Chowdhury, MS; Kawabata, M; Kawai, A; Matsumoto, Y; Saito-Ito, A, 2011) |
| "Ferroquine (FQ), a chloroquine (CQ) analog, is being developed to treat persons with Plasmodium falciparum malaria." | 3.77 | Inhibitory activity of ferroquine, versus chloroquine, against western Kenya Plasmodium falciparum field isolates determined by a SYBR Green I in vitro assay. ( Akala, HM; Eyase, FL; Johnson, JD; Walsh, DS, 2011) |
| "In Honduras, chloroquine and primaquine are recommended and still appear to be effective for treatment of Plasmodium falciparum and Plasmodium vivax malaria." | 3.77 | Drug resistance associated genetic polymorphisms in Plasmodium falciparum and Plasmodium vivax collected in Honduras, Central America. ( Alger, J; Banegas, E; Bjorkman, A; Enamorado, IG; Ferreira, PE; Fontecha, G; Jovel, IT; Mejía, RE; Piedade, R; Ursing, J; Veiga, MI, 2011) |
| "Drug resistance against dihydrofolate reductase (DHFR) inhibitors-such as pyrimethamine (PM)-has now spread to almost all regions where malaria is endemic, rendering antifolate-based malaria treatments highly ineffective." | 3.76 | Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. ( Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B, 2010) |
| " We tested whether chloroquine- and antifolate drug-resistant genotypes would be more commonly associated with cases of cerebral malaria than with cases of mild malaria in the province of Jabalpur, India, by genotyping the dhps, dhfr, pfmdr-1, and pfcrt genes using pyrosequencing, direct sequencing, and real-time PCR." | 3.76 | Evidence of selective sweeps in genes conferring resistance to chloroquine and pyrimethamine in Plasmodium falciparum isolates in India. ( Dash, AP; Jain, V; McCollum, AM; Mixson-Hayden, T; Nagpal, AC; Poe, A; Singh, N; Stiles, JK; Udhayakumar, V, 2010) |
| " They were monitored for development of Plasmodium falciparum malaria, which was treated with chloroquine (CQ) + sulfadoxine-pyrimethamine (SP) and the children followed up for 28 days." | 3.76 | Prolonged elevation of viral loads in HIV-1-infected children in a region of intense malaria transmission in Northern Uganda: a prospective cohort study. ( Egwang, TG; Kiyingi, HS; Nannyonga, M, 2010) |
| " We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge." | 3.75 | Violacein extracted from Chromobacterium violaceum inhibits Plasmodium growth in vitro and in vivo. ( Blanco, YC; Brocchi, M; Costa, FT; Duran, N; Facchini, G; Goelnitz, U; Justo, GZ; Lopes, SC; Nogueira, PA; Rodrigues, FL; Wunderlich, G, 2009) |
| " knowlesi infection had uncomplicated malaria that responded to chloroquine and primaquine treatment." | 3.75 | Clinical and laboratory features of human Plasmodium knowlesi infection. ( Cox-Singh, J; Daneshvar, C; Davis, TM; Divis, PC; Rafa'ee, MZ; Singh, B; Zakaria, SK, 2009) |
| " We now demonstrate the ability of 2-tert-butylprimaquine to inhibit in vitro beta-hematin formation, to form a complex with heme with a stoichiometry of 1:1, and to enhance heme-induced hemolysis." | 3.74 | 2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization. ( Harada, S; Huy, NT; Jain, M; Jain, R; Kamei, K; Kaur, K; Mizunuma, K; Nhien, NT; Uyen, DT, 2007) |
| "These data suggest that, even in low transmission areas, diverse parasite populations can accumulate in the placenta during pregnancy despite strong selection at the PfCRT locus due to chemoprophylaxis with chloroquine." | 3.74 | Accumulation of CVIET Pfcrt allele of Plasmodium falciparum in placenta of pregnant women living in an urban area of Dakar, Senegal. ( Alioune, G; Bouchier, C; Dangou, JM; Ekala, MT; Jambou, R; Lehesran, JY; Marrama, L; Mercereau-Puijalon, O; Ndiaye, JL; Niang, M; Sarr, D; Tall, A, 2008) |
| "In Papua New Guinea, chloroquine (CQ; 25 mg base kg(-1)) is recommended for prophylaxis of malaria during pregnancy, and at the Alexishafen Health Centre women are routinely prescribed CQ at the time of delivery." | 3.74 | Transfer of chloroquine and desethylchloroquine across the placenta and into milk in Melanesian mothers. ( Baiwog, F; Davis, TM; Gomorrai, S; Hackett, LP; Ilett, KF; Karunajeewa, HA; Law, I; Mueller, I; Page-Sharp, M, 2008) |
| "The risk of malaria infection is increased during pregnancy, and many countries recommend chloroquine prophylaxis in pregnant women, despite Plasmodium falciparum chloroquine resistance." | 3.73 | High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal. ( Bertin, G; Deloron, P; Fievet, N; Jafari-Guemouri, S; Le Hesran, JY; Ndam, NT; Renart, E; Sow, S, 2005) |
| "The use of chloroquine treatment for Plasmodium falciparum malaria was abandoned in China in 1979 because of widespread drug resistance." | 3.73 | Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China. ( Chen, L; Chen, P; Fu, L; Guo, X; Li, G; Mu, J; Su, X; Wang, X; Wellems, TE, 2005) |
| " Despite its high resistance level, chloroquine (CQ) is still extensively used as the first-line treatment for uncomplicated Plasmodium falciparum malaria." | 3.73 | Epidemiology of drug-resistant malaria in Republic of Congo: using molecular evidence for monitoring antimalarial drug resistance combined with assessment of antimalarial drug use. ( Durand, R; Jafari-Guemouri, S; Kiori, J; Le Bras, J; Louya, F; Malanda, M; Malonga, DA; Mouata, AM; Nsimba, B; Yocka, D, 2005) |
| "Although chloroquine (CQ) monotherapy is now generally inadequate for the treatment of Plasmodium falciparum malaria in northern Ghana--recently, 58% of 225 children failed treatment by day 14--use of the drug continues because of its low cost and wide availability." | 3.73 | Chloroquine-treatment failure in northern Ghana: roles of pfcrt T76 and pfmdr1 Y86. ( Agana-Nsiire, P; Bienzle, U; Eggelte, TA; Ehrhardt, S; Markert, M; Mathieu, A; Mockenhaupt, FP; Otchwemah, RN; Stollberg, K, 2005) |
| "Between 2002 and 2004, the standardized 28-day protocol recently developed by the World Health Organization was used to explore the efficacy of chloroquine, in the treatment of uncomplicated, Plasmodium falciparum malaria, in five sentinel sites in southern Iran." | 3.73 | Monitoring of the therapeutic efficacy of chloroquine for the treatment of uncomplicated, Plasmodium falciparum malaria in Iran. ( Faraji, L; Keshavarz, H; Nateghpour, M; Raeisi, A; Ranjbar, M; Ringwald, P; Safa, O; Shahbazi, A, 2006) |
| "We developed and evaluated a rapid, real-time polymerase chain reaction (PCR) assay to detect Plasmodium falciparum malaria and chloroquine (CQ)-resistance determinants in returned travelers who are febrile." | 3.73 | Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers. ( Farcas, GA; Kain, KC; Soeller, R; Zahirieh, A; Zhong, K, 2006) |
| "Several factors appear to have accelerated the process: (1) recognition of the extent of the problem of malaria during pregnancy and its adverse consequences; (2) a clear, evidence-based program strategy strongly articulated by an important multilateral organization (World Health Organization); (3) subregionally generated evidence to support the proposed strategy; (4) a subregional forum for dissemination of data and discussion regarding the proposed policy changes; (5) widespread availability of the proposed intervention drug (sulfadoxine-pyrimethamine); (6) technical support from reputable and respected institutions in drafting new policies and planning for implementation; (7) donor support for pilot experiences in integrating proposed policy change into a package of preventive services; and (8) financial support for scaling up the proposed interventions." | 3.73 | Prevention of malaria during pregnancy in West Africa: policy change and the power of subregional action. ( Benga-De, E; Doumbo, O; Faye, O; Gaye, O; Kayentao, K; Lo, Y; Moran, AC; Moreira, PM; Newman, RD; Parise, ME; Steketee, RW; Yameogo, M, 2006) |
| " Gambian children with malaria were treated with chloroquine in 28-day trials, and recovery was defined primarily as the absence of severe clinical malaria at any time and absence of parasitemia with fever after 3 days." | 3.73 | Immunoglobulin G antibodies to merozoite surface antigens are associated with recovery from chloroquine-resistant Plasmodium falciparum in Gambian children. ( Hallett, R; Holder, AA; Ismaili, J; McCall, MB; Milligan, P; Ord, R; Pinder, M; Sisay-Joof, F; Sutherland, CJ, 2006) |
| "We have previously shown that both chloroquine and paracetamol (acetaminophen) have antipyretic activity during treatment of acute uncomplicated Plasmodium falciparum malaria in children 1-4 years old." | 3.73 | Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. ( Björkman, A; Hugosson, E; Montgomery, SM; Premji, Z; Troye-Blomberg, M, 2006) |
| "Chloroquine-resistant plasmodium falciparum malaria is a serious public health threat that is spreading rapidly across Sub-Saharan Africa." | 3.72 | Evaluation of chloroquine as a potent anti-malarial drug: issues of public health policy and healthcare delivery in post-war Liberia. ( Kennedy, SB; Massaquoi, MB, 2003) |
| "In West Africa, administration of chloroquine chemoprophylaxis during pregnancy is common, but little is known about its impact on Plasmodium falciparum infection during pregnancy." | 3.72 | Failure of a chloroquine chemoprophylaxis program to adequately prevent malaria during pregnancy in Koupéla District, Burkina Faso. ( Diarra, A; Konate, A; Moran, AC; Newman, RD; Parise, ME; Sawadogo, R; Sirima, SB; Yameogo, M, 2003) |
| "Chloroquine-resistant Plasmodium vivax malaria was first reported in India in 1995." | 3.72 | Monitoring the chloroquine sensitivity of Plasmodium vivax from Calcutta and Orissa, India. ( Addy, M; Bandyopadhyay, AK; Maji, AK; Nandy, A, 2003) |
| "The influence of combinations containing the blood schizontocides chloroquine (CQ) or mefloquine (MEF), together with the 8-aminoquinolines (8AQ) primaquine (PQ) or the new, long-acting compound, tafenoquine (TAF), on the rate of selection of resistance to the individual compounds was examined using the asexual, intra-erythrocytic stages in rodent malaria models." | 3.72 | The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines. ( Peters, W; Robinson, BL; Stewart, LB, 2003) |
| " All recurrent parasitemias occurred with whole blood levels of chloroquine plus desethylchloroquine exceeding 100 ng/ml." | 3.72 | Very high risk of therapeutic failure with chloroquine for uncomplicated Plasmodium falciparum and P. vivax malaria in Indonesian Papua. ( Baird, JK; Fryauff, DJ; Leksana, B; Subianto, B; Sumawinata, IW; Sutamihardja, A, 2003) |
| "In 1993, Malawi stopped treating patients with chloroquine for Plasmodium falciparum malaria because of a high treatment failure rate (58%)." | 3.72 | Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi. ( Björkman, A; Bwijo, B; Kaneko, A; Kobayakawa, T; Lum, JK; Mita, T; Takechi, M; Tanabe, K; Tsukahara, T; Zungu, IL, 2003) |
| "Nearly half of all infants in a Ugandan cohort are exposed to chloroquine in the last trimester of pregnancy." | 3.72 | Effect of chloroquine on human immunodeficiency virus (HIV) vertical transmission. ( Bagenda, D; Kalyesubula, I; Myers, C; Neely, M; Olness, K, 2003) |
| "The efficacy of amodiaquine against Plasmodium falciparum malaria was assessed in an area of confirmed chloroquine resistance in the cool, north-central plateau of Nigeria, using a 14-day protocol." | 3.72 | Amodiaquine treatment of uncomplicated malaria in children, in an area of chloroquine-resistant Plasmodium falciparum in north-central Nigeria. ( Adeniji, B; Afolabi, BM; Amajoh, CN; Ekanem, OJ; Molta, NB; Odujoko, JB; Oguche, S; Omalu, IC; Pam, SD; Wuyep, VP, 2003) |
| " Whole blood concentrations of chloroquine, sulfadoxine, and quinine were determined at different intervals and at the time of parasites recrudescence after completion of treatment with the respective drugs to confirm the status of drug sensitivity." | 3.72 | Multi-drug resistant Plasmodium falciparum malaria in Assam, India: timing of recurrence and anti-malarial drug concentrations in whole blood. ( Dev, V; Dua, VK; Gupta, NC; Phookan, S; Sharma, VP; Subbarao, SK, 2003) |
| "A non-compartmental pharmacokinetic model was used to describe the changes in gametocytaemia in nine children with chloroquine-sensitive Plasmodium falciparum malaria in whom asexual parasitaemia cleared within 72 h of chloroquine treatment." | 3.72 | Changes in Plasmodium falciparum gametocytaemia in children with chloroquine-sensitive asexual infections. ( Fateye, BA; Sowunmi, A, 2003) |
| "In Togo, chloroquine (CQ) remains the first-line drug for the treatment of uncomplicated, Plasmodium falciparum malaria." | 3.72 | Chloroquine efficacy in the treatment of uncomplicated malaria at three sentinel sites in northern Togo. ( Adjogble, K; Agbo, K; Avodagbe, A; Dekou, K; Djadou, KE; Kassankogno, Y; Malvy, JM; Millet, P; Morgah, K; Penali, KL; Pignandi, A; Sodahlon, YK; Sukwa, T, 2003) |
| " The present study was undertaken to evaluate the efficacy of arteether on acute chloroquine resistant Plasmodium falciparum malaria in eastern coalfield area of Asansol." | 3.72 | Efficacy of arteether in chloroquine resistant falciparum malaria in eastern India. ( Mandal, PK; Pal, A; Sarkar, N, 2004) |
| " The four drivers had been treated with chloroquine and proguanil but the dosage may have been insufficient with regard to their body weight (average weight = 110 kg)." | 3.71 | [A collective malarial infestation during a humanitarian mission in west Africa]. ( Beytout, J; Caumon, L; Chouaki, M; Cueto, T; Delort, P; Dufraise, S; Monchard, F; Philippe, JM; Rimeize, H, 2002) |
| "Nias Island, off the north-western coast of Sumatra, Indonesia, was one of the first locations in which chloroquine-resistant Plasmodium vivax malaria was reported." | 3.71 | The drug sensitivity and transmission dynamics of human malaria on Nias Island, North Sumatra, Indonesia. ( Atmosoedjono, S; Baird, JK; Bangs, MJ; Fryauff, DJ; Leksana, B; Masbar, S; Nagesha, HS; Sismadi, P; Susanti, AI; Wiady, I, 2002) |
| "The efficacy of chloroquine treatment of uncomplicated Plasmodium falciparum malaria in East Timor was investigated via molecular tools." | 3.71 | Short report: Molecular evaluation of the efficacy of chloroquine treatment of uncomplicated Plasmodium falciparum malaria in East Timor. ( Baker, J; Burns, M; Chen, N; Cheng, Q; Edstein, MD; Ezard, N, 2002) |
| "Chloroquine is a first line drug for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda." | 3.71 | Resistance patterns of Plasmodium falciparum malaria to chloroquine in Kampala, Uganda. ( Freers, J; Mayanja-Kizza, H; Mulindwa, HC, 2002) |
| "A protocol for assessment of the therapeutic efficacy of chloroquine against Plasmodium falciparum malaria was evaluated in Sudan." | 3.71 | Sentinel posts for monitoring therapeutice efficacy of antimalarial drugs against Plasmodium falciparum infections in the Sudan. ( Abdel-Hameed, AA; El-Jak, IE; Faragalla, IA, 2001) |
| "Chloroquine-resistant Plasmodium falciparum malaria is a major health problem, particularly in sub-Saharan Africa." | 3.71 | A molecular marker for chloroquine-resistant falciparum malaria. ( Cortese, JF; Coulibaly, D; Dicko, A; Diourté, Y; Djimdé, A; Doumbo, OK; Doumbo, S; Fidock, DA; Kayentao, K; Nomura, T; Plowe, CV; Su, XZ; Wellems, TE, 2001) |
| "To establish the effects of chloroquine on kidney function we monitored renal parameters in age and sex matched control subjects and patients who presented with acute transient fever." | 3.70 | Chloroquine influences renal function in rural Zimbabweans with acute transient fever. ( Munjeri, O; Musabayane, CT; Musvibe, A; Osim, EE; Wenyika, J, 1999) |
| " Seventy patients with Plasmodium falciparum malaria were included in a study of resistance to chloroquine and sulfadoxine-pyrimethamine therapy." | 3.70 | Chemotherapy of malaria and resistance to antimalarial drugs in Guayana area, Venezuela. ( Caraballo, A; Rodriguez-Acosta, A, 1999) |
| " At present, under the National guidelines; all fevers are presumed to be due to malaria and chloroquine is given as presumptive treatment." | 3.70 | Clinical case definition of malaria at a secondary level hospital in northern India. ( Anand, K; Kant, S; Kapoor, SK; Kumar, G, 1999) |
| " Mefloquine should be recommended as prophylaxis to the majority of travellers visiting regions with chloroquine-resistant malaria." | 3.70 | [Malaria imported to Norway 1989-98]. ( Blystad, H, 2000) |
| "1%) took anti-malaria prophylaxis (chloroquine) in the index pregnancy, and 136 (58." | 3.70 | Effect of chloroquine prophylaxis on birthweight and malaria parasite load among pregnant women delivering in a regional hospital in Cameroon. ( Ratard, R; Salihu, HM; Tchuinguem, G, 2000) |
| "The sensitivities of 61 Indian cases of Plasmodium falciparum malaria to chloroquine (CQ) were investigated using in-vitro and in-vivo methods." | 3.70 | Chloroquine and desethylchloroquine concentrations in blood cells and plasma from Indian patients infected with sensitive or resistant Plasmodium falciparum. ( Dua, VK; Edwards, G; Gupta, NC; Kar, PK; Nand, J; Sharma, VP; Subbarao, SK, 2000) |
| "The antimalarial peroxide, dispiro-1,2,4,5-tetraoxane WR 148999, was synergistic with chloroquine, quinine, mefloquine, and artemisinin against both D6 and W2 clones of Plasmodium falciparum." | 3.70 | Assessment of the antimalarial potential of tetraoxane WR 148999. ( Ager, AL; Andersen, SL; Angerhofer, CK; Grace, JM; Hu, JK; Vennerstrom, JL; Wesche, DL; Wongpanich, V, 2000) |
| " The children had persistent fever (5 or more days) despite treatment with chloroquine and were admitted to the Department of Child Health of the University of Ghana Medical School in Accra with severe malaria (Plasmodium falciparum)." | 3.69 | Persistent fever in severe malaria in children. ( Agyepong, I; Commey, J; Quarm-Goka, B, 1994) |
| " A patient with Plasmodium falciparum malaria, severe hyponatremia and hypokalaemia who regurgitated oral treatment of chloroquine phosphate and pyrimethamine and sulfadoxine (Fansidar) is presented." | 3.69 | Falciparum malaria treated with a chloroquine suspension administered rectally in Trinidad. ( Chadee, DD; Chen, A; Doon, R; Le Maitre, A; Poon-King, TM; Tilluckdharry, CC, 1994) |
| "United States military personnel deployed to Somalia were at risk for malaria, including chloroquine-resistant Plasmodium falciparum malaria." | 3.69 | Malaria among United States troops in Somalia. ( Batchelor, R; Burans, JP; Iriye, C; Lobel, HO; Longer, CF; Magill, AJ; Rozmajzl, P; Sharp, TW; Smoak, B; Thornton, SA; Wallace, MR, 1996) |
| "While there is broad evidence for the adverse effects of Plasmodium falciparum infection in pregnancy, and the World Health Organization recommends preventive strategies, there is markedly reduced efficacy in sub-Saharan Africa of the most widely available, affordable and used antimalarial drug for chemoprophylaxis-chloroquine (CQ)." | 3.69 | The effect of malaria and malaria prevention in pregnancy on offspring birthweight, prematurity, and intrauterine growth retardation in rural Malawi. ( Breman, JG; Heymann, DL; Hightower, AW; Slutsker, L; Steketee, RW; Wirima, JJ, 1996) |
| "6 months of pregnancy), placed on one of three chloroquine regimens, and followed through delivery." | 3.69 | Impairment of a pregnant woman's acquired ability to limit Plasmodium falciparum by infection with human immunodeficiency virus type-1. ( Bloland, PB; Breman, JG; Chilima, B; Chitsulo, L; Mermin, JH; Steketee, RW; Wirima, JJ, 1996) |
| " In a cohort of pregnant women enrolled at first antenatal clinic visit in rural Malawi, we evaluated reported fever, determined parasitemia, and placed the women on antimalarial regimens containing chloroquine (CQ) or mefloquine (MQ)." | 3.69 | Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine. ( Breman, JG; Heymann, DL; Khoromana, CO; Slutsker, L; Steketee, RW; Wirima, JJ, 1996) |
| "The objective of the study was to determine the efficacy of chloroquine in pregnant women with Plasmodium falciparum parasitemia at therapeutic doses of 25 mg/kg body weight divided over 3 days." | 3.69 | Resistance to chloroquine therapy in pregnant women with malaria parasitemia. ( Ojwang, SB; Oyieke, JB; Rukaria-Kaumbutho, RM, 1996) |
| "Plasmodium falciparum sensitivity to quinine in São Tomé was determined by in vivo and in vitro tests in 56 children with mild or cerebral malaria." | 3.69 | Plasmodium falciparum chloroquine and quinine sensitivity in asymptomatic and symptomatic children in São Tomé Island. ( Baptista, JL; D'Alessandro, U; Das Neves, I; Hendrix, L; Wéry, M, 1997) |
| "Several reports have confirmed the existence of chloroquine resistant Plasmodium falciparum malaria in Bombay." | 3.69 | Efficacy of sulfadoxine-pyrimethamine in chloroquine resistant falciparum malaria in Bombay. ( Garg, MR; Gogtay, NJ; Kshirsagar, NA, 1996) |
| "The efficacity of oral chloroquine was assessed in 360 out-clinic patients with symptomatic Plasmodium falciparum malaria who were enrolled at five sites, in four administrative regions of Senegal, between 1991 and 1995." | 3.69 | [In vivo chemosensitivity tests of Plasmodium falciparum to chloroquine in Senegal: the development of resistance and the assessment of therapeutic efficacy]. ( Molez, JF; Ndiaye, P; Sane, B; Sokhna, CS; Trape, JF, 1997) |
| " Chloroquine, quinine and pyrimethamine, administered after macrogametocytes of Plasmodium falciparum had been found in the blood smear, eliminated the parasites from the peripheral blood, but respiratory failure and treatment-resistant pneumonia occurred, leading to the adult respiratory distress syndrome (Morel stage 4)." | 3.68 | [Acute respiratory failure in tropical malaria during pregnancy. Successful treatment using extracorporeal CO2 elimination]. ( Benzing, A; Dippold, W; Grundmann, H; Knolle, P; Meyer zum Büschenfelde, KH; Neurath, M, 1993) |
| "The antimalarial activity of beta-artemether and beta-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P." | 3.68 | Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. ( Ager, AL; Canfield, CJ; Heiffer, MH; Klayman, DL; Kyle, DE; Milhous, WK; Rossan, RN; Schuster, BG; Shmuklarsky, MJ; Tang, DB, 1993) |
| "Currently, most of the subjects presenting with Plasmodium falciparum malaria in France come from areas where chloroquine resistance has already been reported." | 3.68 | [Treatment of malaria in children in France]. ( Badoual, J, 1992) |
| "The clinical and parasitologic efficacies of oral chloroquine phosphate, pyrimethamine/sulphadoxine and pyrimethamine/sulphalene in treating Plasmodium falciparum malaria were assessed in selected sites of northeastern Nigeria (Zone D of the Primary Health Care (PHC) Programme) using a 14-day standard in-vivo protocol during 1988-1990." | 3.68 | Efficacies of chloroquine, pyrimethamine/sulphadoxine and pyrimethamine/sulphalene against P. falciparum in northeastern Nigeria. ( Ameh, JO; Daniel, HI; Gadzama, NM; Molta, NB; Oguche, SO; Otu, TI; Watila, IM, 1992) |
| " Eleven volunteers received chloroquine in usually curative doses on a three-day schedule during acute clinical malaria attacks." | 3.64 | STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM THAILAND. ( ALVING, AS; BREWER, GJ; MILLAR, JW; POWELL, RD, 1964) |
| "Methods to fight malaria are being diversified, including the use of mosquito nets, the target candidate profiles (TCPs) and target product profiles (TPPs) of medicine for malarial venture (MMV) strategy, the search for newer and potent drugs that could reverse chloroquine resistance, and the use of adjuvants such as rosiglitazone and sevuparin." | 3.01 | Recent developments in antimalarial drug discovery. ( Habarurema, G; Hahirwa, I; Katembezi, AN; Kayitare, E; Kayumba, PC; Mpenda, M; Muganga, R; Mukazayire, MJ; Mukiza, J; Nkuranga, JB; Nyandwi, JB; Olawode, EO; Umumararungu, T, 2023) |
| " 80% of subjects in the CQAZ group experienced treatment related gastrointestinal adverse events (including 13% that experienced severe nausea) compared to 38% in the CQ group." | 2.94 | An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria inf ( Bennett, J; Cicatelli, S; DeLuca, J; Duncan, EH; Hamer, M; Hutter, J; Kreishman-Deitrick, M; Lee, C; Livezey, J; Mills, K; Moon, JE; Morrison, M; Oliver, T; Poon, L; Sedegah, M; Selig, D; Sikaffy, A; Sousa, J; Tosh, D; Twomey, P; Vuong, C; Waterman, P, 2020) |
| "Prevention and treatment of malaria depend on the species and the drug sensitivity of parasites from the region of acquisition." | 2.82 | Diagnosis, Treatment, and Prevention of Malaria in the US: A Review. ( Daily, JP; Khan, N; Minuti, A, 2022) |
| " Vaccinees (11/20, 55%) and controls (6/10, 60%) had the same percentage of mild to moderate solicited adverse events." | 2.82 | Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers Under Chloroquine Prophylaxis: A Randomized Controlled Trial. ( Bastiaens, GJH; Bijker, EM; Billingsley, PF; de Mast, Q; Graumans, W; Gunasekera, A; Hermsen, CC; Hoffman, SL; James, ER; Obiero, JM; Sauerwein, RW; Scholzen, A; Sim, BKL; van de Vegte-Bolmer, M; van der Ven, AJAM; van Gemert, GJ; van Grinsven, T; van Meer, MPA; Vatanshenassan, M, 2016) |
| " To optimize ID PfSPZ dosing so as to achieve 100% infection, 30 adults aged 18-45 years were randomized to one of six groups composed of five volunteers each." | 2.80 | Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection. ( Adams, M; Billingsley, PF; Chakravarty, S; Dube, TJ; Edelman, R; Green, M; Hoffman, SL; James, E; Laurens, MB; Li, ML; Lyke, KE; Manoj, A; Plowe, CV; Ruben, A; Sim, BKL; Strauss, K, 2015) |
| " Dosing of AZCQ was approximately 30 mg/kg AZ and 10 mg/kg CQ once daily for 3 days (for ≥20 kg weight: AZ/CQ 300/100 mg per tablet; 5 to <20 kg weight: AZ/CQ 150/50 mg per tablet)." | 2.79 | Population pharmacokinetics of azithromycin and chloroquine in healthy adults and paediatric malaria subjects following oral administration of fixed-dose azithromycin and chloroquine combination tablets. ( Chandra, R; Mould, DR; Tensfeldt, TG; Zhao, Q, 2014) |
| " CPS-MQ immunization is safe and equally potent compared to CPS-CQ inducing protection in 7/10 (70%) versus 3/5 (60%) volunteers, respectively." | 2.79 | Sporozoite immunization of human volunteers under mefloquine prophylaxis is safe, immunogenic and protective: a double-blind randomized controlled clinical trial. ( Bastiaens, GJ; Behet, MC; Bijker, EM; Graumans, W; Hermsen, CC; Obiero, JM; Sauerwein, RW; Schats, R; Scholzen, A; Teelen, K; van de Vegte-Bolmer, M; van Gemert, GJ; van Lieshout, L; Visser, LG, 2014) |
| " Serious adverse events (AEs; all causality) were observed more frequently with MQ compared with AZCQ (four vs one, respectively), though discontinuations for AEs were similar (four vs three, respectively)." | 2.79 | Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults. ( Chandra, R; Dieng, Y; Djimdé, AA; Dunne, MW; Kain, KC; Mugyenyi, P; Mulenga, M; Oduro, AR; Ogutu, B; Robbins, J; Sagara, I; Sarkar, S; Sie, A; Tiono, AB; Wasunna, M, 2014) |
| "Falciparum malaria is a significant problem for Afghan refugees in Pakistan." | 2.76 | Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan. ( Beshir, K; Durrani, N; Hallett, R; Howard, N; Rowland, M; Sanda, S, 2011) |
| "falciparum malaria were enrolled." | 2.75 | Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance. ( Oguonu, T; Okafor, HU; Shu, EN, 2010) |
| "Chloroquine was used as first-line treatment for Plasmodium falciparum or Plasmodium vivax in Indonesia before the initial launch of artemisinin combination therapy in 2004." | 2.75 | Evaluation of chloroquine therapy for vivax and falciparum malaria in southern Sumatra, western Indonesia. ( Baird, JK; Endawati, D; Laihad, F; Ling, LH; Setiabudy, R; Sutanto, I, 2010) |
| "Chloroquine treatment led to a decrease in EPO levels in the control subjects but an increase in malaria patients at day 30." | 2.74 | Effects of chloroquine treatment on circulating erythropoietin and inflammatory cytokines in acute Plasmodium falciparum malaria. ( Ballal, A; Jelkmann, W; Rouina, P; Saeed, A, 2009) |
| "Amodiaquine was the most effective on fever." | 2.74 | Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali. ( Beavogui, AH; Dama, S; Dembele, D; Dicko, A; Djimde, AA; Doumbo, OK; Fofana, B; Kone, A; Maiga, H; Ouologuem, D; Sagara, I; Tekete, M; Wele, M, 2009) |
| "falciparum malaria were enrolled at six sites in four states, treated with chloroquine and follow-up was done for 28 days." | 2.74 | Low efficacy of chloroquine: time to switchover to artemisinin-based combination therapy for falciparum malaria in India. ( Das, MK; Dash, AP; Joshi, H; Kumar, A; Mallick, PK; Nagpal, BN; Shahi, B; Sharma, SK; Tyagi, PK; Valecha, N, 2009) |
| " The main outcome measures for safety were incidences of post-treatment clinical and laboratory adverse events." | 2.74 | Artemisinin-naphthoquine combination (ARCO) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: a preliminary report on safety and efficacy. ( Geita, J; Hiawalyer, G; Hombhanje, FW; Jones, R; Kevau, I; Kuanch, C; Linge, D; Masta, A; Sapuri, M; Saweri, A; Toraso, S, 2009) |
| "To compare the adverse effects of two regimens of chlorpheniramine plus chloroquine (CP+CQ) in children who live in a country where chloroquine resistant malaria is endemic." | 2.74 | Potential toxicity of chlorpheniramine plus chloroquine for the treatment of childhood malaria. ( Adedapo, AD; Adedapo, KS; Ademowo, OG; Demissie, K; Osinubi, OY, 2009) |
| "06 liters/h/kg), the median distribution half-life (t 1/2 alpha) was 0." | 2.73 | Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria. ( Batty, KT; Davis, TM; Ilett, KF; Karunajeewa, HA; Lammey, J; Law, I; Lin, E; Mueller, I; Page-Sharp, M; Siba, P, 2008) |
| "Chloroquine (CQ) is an effective treatment of choice for vivax malaria in most settings, but with the spread of CQ-resistant Plasmodium falciparum, many countries now use artemisinin-based combination therapy for treatment of falciparum malaria." | 2.73 | Sulfadoxine-pyrimethamine plus artesunate compared with chloroquine for the treatment of vivax malaria in areas co-endemic for Plasmodium falciparum and P. vivax: a randomised non-inferiority trial in eastern Afghanistan. ( Durrani, N; Kolaczinski, K; Rahim, S; Rowland, M, 2007) |
| "vivax malaria were treated according to the new policy guidelines (i." | 2.73 | Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea. ( Beck, HP; Genton, B; Goroti, M; Maku, P; Marfurt, J; Müeller, I; Reeder, JC; Sie, A, 2007) |
| " * The available data on CQ, SDx and PYR are summary pharmacokinetic parameters based on classical/traditional methods, mostly in adults." | 2.73 | Population pharmacokinetics of chloroquine and sulfadoxine and treatment response in children with malaria: suggestions for an improved dose regimen. ( Gordi, T; Gustafsson, LL; Hellgren, U; Jerling, M; Ntale, M; Obua, C; Ogwal-Okeng, JW, 2008) |
| "A study was conducted to investigate a possible pharmacokinetic interaction between azithromycin and chloroquine." | 2.72 | Lack of a pharmacokinetic interaction between azithromycin and chloroquine. ( Bramson, CR; Cook, JA; Randinitis, EJ; Wesche, DL, 2006) |
| "Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover been shown to selectively inhibit the Plasmodium falciparum glutathione reductase." | 2.72 | Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine. ( Burhenne, J; Coulibaly, B; Jahn, A; Kouyaté, B; Mandi, G; Mansmann, U; Meissner, PE; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Schiek, W; Schirmer, RH; Tapsoba, T; Walter-Sack, I; Witte, S, 2006) |
| "Amodiaquine (AQ) is an affordable compound, chemically related to chloroquine (CQ) but often effective against CQ resistant Plasmodium falciparum." | 2.72 | Improved efficacy with amodiaquine instead of chloroquine in sulfadoxine/pyrimethamine combination treatment of falciparum malaria in Uganda: experience with fixed-dose formulation. ( Aguttu, C; Anokbonggo, WW; Chiria, J; Gustafsson, LL; Hellgren, U; Obua, C; Ogwal-Okeng, JW, 2006) |
| "Chloroquine was prescribed at 25 mg per kg body weight, and administered over 3 days to patients suffering from uncomplicated malaria." | 2.71 | [In vivo evaluation of chloroquine therapeutic efficacy in uncomplicated Plasmodium falciparum malaria in Central African Republic ine 1997 and 1998]. ( Barrau, K; Bergeri, I; Delmont, J; Madji, N; Namsenmo, A; Ndoyo, J; Zoguéreh, DD, 2003) |
| " The findings indicate that - at least at the dosing regimen used in the present study and among children with acute, uncomplicated, P." | 2.71 | A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Sowunmi, A, 2003) |
| "The effectiveness of chloroquine or sulfadoxine-pyrimethamine administered with artesunate for treating uncomplicated falciparum malaria was assessed in 2 Vietnamese provinces where the sensitivity of parasites in vitro to conventional therapies had increased with the removal of drug pressure." | 2.71 | Treatment of uncomplicated falciparum malaria in southern Vietnam: can chloroquine or sulfadoxine-pyrimethamine be reintroduced in combination with artesunate? ( Cox-Singh, J; Davis, TM; Doan, HN; Hewitt, S; Le, DC; Nguyen, MH; Nguyen, TH; Tran, BK; Tran, QT; Vo, NP, 2003) |
| "falciparum malaria were treated with either CQ monotherapy (n=120) or the combination of CQ plus three doses of AS (CQ/AS; n=352)." | 2.71 | Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes. ( Coleman, R; Drakeley, CJ; Jawara, M; Obisike, U; Pinder, M; Sutherland, CJ; Targett, GA; Walraven, G, 2004) |
| " In 2002, we assessed the efficacy of SP alone and combined with amodiaquine (AQ/SP) or chloroquine (CQ/SP) in Ugandan children with uncomplicated falciparum malaria." | 2.71 | Efficacy of sulphadoxine-pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan children. ( Bakyaita, N; D'Alessandro, U; Egwang, TG; Langi, P; Mutabingwa, TK; Nalunkuma-Kazibwe, A; Talisuna, AO; Van Marck, E; Watkins, WW, 2004) |
| " Therefore, standard dosages of MB appear to be safe in G6PD-deficient African populations with predominantly class III G6PD deficiency." | 2.71 | Safety of the combination of chloroquine and methylene blue in healthy adult men with G6PD deficiency from rural Burkina Faso. ( Burhenne, J; Coulibaly, B; Jahn, A; Kouyaté, B; Mandi, G; Mansmann, U; Meissner, P; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Sanon, M; Schiek, W; Schirmer, H; Walter-Sack, I; Witte, S; Wüst, K, 2005) |
| "Chloroquine resistance was detected at the RI level in 29 cases (13%) and RII level in 8 cases (4%)." | 2.71 | The drug sensitivities of Plasmodium falciparum in the Sonitpur district, Assam, India. ( Baruah, I; Das, SC; Talukdar, PK, 2005) |
| " The primary outcome was the incidence of severe haemolysis or other serious adverse events (SAEs)." | 2.71 | Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]. ( Burhenne, J; Coulibaly, B; Jahn, A; Kouyaté, B; Mandi, G; Mansmann, U; Meissner, PE; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Sanon, M; Schiek, W; Schirmer, H; Tapsoba, T; Walter-Sack, I; Witte, S, 2005) |
| "Chloroquine combined with primaquine was evaluated for therapy of uncomplicated malaria caused by Plasmodium falciparum in nonimmune Javanese migrants to northeastern Papua, Indonesia." | 2.70 | Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, Indonesia. ( Ayomi, E; Baird, JK; Basri, H; Fryauff, DJ; Hoffman, SL; Sutanihardja, A; Wiady, I, 2002) |
| "Quinine (30 mg/kg) was totally effective in curing patients in all three areas." | 2.70 | In vivo drug resistance of falciparum malaria in mining areas of Venezuela. ( Aché, A; Díaz, O; Escorihuela, M; Izarra, E; Matos, A; Miranda, L; Páez, E; Pérez, W; Vivas, E, 2002) |
| "falciparum malaria was compared with that of CQ, each drug being given at 10 mg/kg per day for 3 days (days 0, 1 and 2)." | 2.70 | Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Adedeji, AA; Ayede, AI; Falade, AG; Falade, CO; Happi, TC; Ndikum, VN; Oduola, AM; Sowunmi, A; Sowunmi, CO, 2001) |
| "Chloroquine resistance has long been known to be present in the hyperendemic lowlands of Burundi, but no data have so far been reported on the response to antimalarials in the highlands of the country." | 2.69 | Response of uncomplicated falciparum malaria to oral chloroquine and quinine in Burundi highlands. ( Allegranzi, B; Bonora, S; Concia, E; Deganello, R; Di Perri, G; Nardi, S; Olliaro, P; Vento, S, 1998) |
| "Atovaquone-proguanil was well tolerated and more effective than chloroquine or chloroquine-sulfadoxine-pyrimethamine for treatment of multidrug-resistant falciparum malaria in the Philippines." | 2.69 | Atovaquone-proguanil compared with chloroquine and chloroquine-sulfadoxine-pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines. ( Bustos, DG; Canete-Miguel, E; Canfield, CJ; Hutchinson, DB, 1999) |
| "Primaquine was better tolerated than chloroquine." | 2.68 | Primaquine for prophylaxis against malaria among nonimmune transmigrants in Irian Jaya, Indonesia. ( Baird, JK; Bangs, MJ; Basri, H; Fryauff, DJ; Leksana, B; Masbar, S; Richie, TL; Subianto, B; Wiady, I, 1995) |
| "Primaquine was tested as a prophylactic drug against Plasmodium falciparum in a region in western Kenya in which malaria is holoendemic." | 2.68 | Daily primaquine is effective for prophylaxis against falciparum malaria in Kenya: comparison with mefloquine, doxycycline, and chloroquine plus proguanil. ( Hoffman, SL; Johnson, A; Koech, D; Oloo, AJ; Weiss, WR, 1995) |
| "Pyronaridine is an acridine derivative which has been used successfully to treat malaria in China for more than 20 years." | 2.68 | Randomised trial of pyronaridine versus chloroquine for acute uncomplicated falciparum malaria in Africa. ( Basco, L; Bickii, J; Ringwald, P, 1996) |
| "falciparum for at least 14 days." | 2.68 | Efficacy of oral and intravenous artesunate in male Tanzanian adults with Plasmodium falciparum malaria and in vitro susceptibility to artemisinin, chloroquine, and mefloquine. ( Alin, MH; Ashton, M; Bjorkman, A; Bwijo, BA; Kihamia, CM; Mtey, GJ; Premji, Z, 1995) |
| "Halofantrine was the most efficacious drug with 82% of the cases cured followed by fansidar(R)(62%), amodiaquine (55%) and chloroquine (29%)." | 2.68 | A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar in the treatment of uncomplicated malaria in children. ( Anabwani, GM; Esamai, FO; Menya, DA, 1996) |
| " All drug dosing was performed under supervision by the study team, making this an evaluation of intervention efficacy (excluding the role of patient compliance)." | 2.68 | Objectives and methodology in a study of malaria treatment and prevention in pregnancy in rural Malawi: The Mangochi Malaria Research Project. ( Breman, JG; Heymann, DL; Khoromana, CO; Slutsker, WL; Steketee, RW; Wirima, JJ, 1996) |
| "The efficacy and toxicity of oral quinine combined with oral chloroquine were studied in 50 Thai men with uncomplicated falciparum malaria." | 2.68 | Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria. ( Chantra, A; Chindanond, D; Clemens, R; Phophak, N; Pukrittayakamee, S; Vanijanonta, S, 1996) |
| "Halofantrine-primaquine was significantly more effective than chloroquine-primaquine against falciparum malaria (P < 0." | 2.68 | Halofantrine and primaquine for radical cure of malaria in Irian Jaya, Indonesia. ( Baird, JK; Bangs, MJ; Basri, H; Fryauff, DJ; Harjosuwarno, S; Hoffman, SL; Richie, TL; Subianto, B; Tjitra, E; Wiady, I, 1997) |
| "falciparum." | 2.68 | In vivo resistance to chloroquine by Plasmodium vivax and Plasmodium falciparum at Nabire, Irian Jaya, Indonesia. ( Baird, JK; Fryauff, DJ; Leksana, B; Subianto, B; Sutanihardja, MA; Wiady, I; Widjaya, H, 1997) |
| "falciparum malaria were randomly treated with either amodiaquine or chloroquine 25 mg/kg, divided over three days." | 2.67 | A comparison of amodiaquine and chloroquine in the treatment therapy of falciparum malaria in Kenya. ( Munafu, CG; Nevill, CG; ten Hove, WR; van der Kaay, HJ; Verhoeff, FH; Were, JB, 1994) |
| "Chloroquine treatment cured 15 patients (36%)." | 2.67 | Curing of chloroquine-resistant malaria with clindamycin. ( Bienzle, U; Brandts, C; Graninger, W; Kremsner, PG; Winkler, S, 1993) |
| "Halofantrine was administered as prophylaxis for malaria to mine workers returning from endemic areas of Papua New Guinea." | 2.67 | Postexposure administration of halofantrine for the prevention of malaria. ( Edstein, MD; Kereu, RK; Rieckmann, KH; Shanks, GD; Spicer, PE, 1993) |
| "Halofantrine hydrochloride was administered under supervision at the standard dose of 24 mg/kg as 8 mg/kg given three times at 6-hr intervals with an observation period of 1 hr after each 8-mg/kg dose." | 2.67 | In vivo sensitivity of Plasmodium falciparum to halofantrine hydrochloride in Burkina Faso. ( Bougouma, L; Del Nero, L; Lamizana, L; Nebie, I; Pietra, V; Sare, S, 1994) |
| "Treatment with chloroquine failed to produce either a durable clinical improvement or optimal hematologic recovery." | 2.67 | Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa. ( Bloland, PB; Campbell, CC; Kazembe, PN; Lackritz, EM; Steketee, R; Were, JB, 1993) |
| "Chloroquine was taken by 278 men (100 mg daily for 6 weeks after their return to France); the other 480 men were given two doses of 1,500 mg halofantrine on the third and on the tenth day after their return to France." | 2.67 | [Efficacy of radical treatment with halofantrine on the prevention of imported Plasmodium falciparum malaria]. ( Baudon, D; Bernard, J; Lantrade, P; Martet, G; Mouliat-Pelat, JP; Picq, JJ; Sarrouy, J; Spiegel, A; Touzé, JE, 1992) |
| "Artemether is an oil-soluble methyl ether of artemesinin (qinghaosu)." | 2.67 | Comparison of artemether and chloroquine for severe malaria in Gambian children. ( Brewster, D; Chapman, D; Crawley, J; Greenwood, BM; Nosten, F; Waller, D; White, NJ, 1992) |
| " No major adverse events were recorded for either treatment group although five patients on artemether had a transient spike of temperature after clearance of parasitaemia." | 2.67 | A comparative study of the schizontocidal efficacy and safety of artemether versus chloroquine in uncomplicated malaria. ( Chandiwana, S; Mharakurwa, S; Mutetwa, S; Neill, P; Simooya, O; Stein, M, 1992) |
| "Amodiaquine and FansidarR were fully effective in eliminating asexual parasitaemia from the blood in all the cases during the seven days of follow-up." | 2.67 | Falciparum malaria fully cleared by amodiaquine, pyrimethamine-sulfadoxine and pyrimethamine-sulfalene in areas of chloroquine resistance in Dodoma, Tanzania. ( Irare, SG; Lemnge, MM; Mhina, JI, 1991) |
| "Chloroquine has been the standard of care for P." | 2.61 | AQ-13 - an investigational antimalarial drug. ( Held, J; Kreidenweiss, A; Mengue, JB, 2019) |
| "falciparum malaria have been the subject of extensive study." | 2.49 | Genetics of chloroquine-resistant malaria: a haplotypic view. ( Awasthi, G; Das, A, 2013) |
| "Continued use of chloroquine for treatment of P falciparum malaria in India will likely be ineffective." | 2.47 | Antimalarial drug resistance of Plasmodium falciparum in India: changes over time and space. ( Arora, U; Dash, AP; Dhillon, GP; Meshnick, SR; Shah, NK; Valecha, N, 2011) |
| "Atovaquone/proguanil has been registered in Europe for travels of up to four weeks, but in the United States there is no upper limit for the duration of use." | 2.43 | [Malaria chemoprophylaxis]. ( Petersen, JE, 2005) |
| "Malaria is frequently a deadly disease, particularly in tropical countries of the world where this protozoan infection is endemic." | 2.41 | Malaria: a rising incidence in the United States. ( Broder, JS; Colletti, JE; Geroff, AJ; Grundmann, KA; Hanna, JR; Jerrard, DA; Mattu, A, 2002) |
| "All drugs used for malaria prophylaxis have common adverse effects, in addition to rare and/or severe adverse effects." | 2.41 | Safety evaluation of the drugs available to prevent malaria. ( Beer, MD; Cook, GC; Croft, AM; Whitehouse, DP, 2002) |
| " Further research is needed to determine the best dosage regimen for antimalarial drugs used for chemoprophylaxis in children." | 2.41 | Antimalarial chemoprophylaxis in infants and children. ( Kramer, MH; Lobel, HO, 2001) |
| " For optimal efficacy, treatment regimens must be adjusted with regard to dosage of primaquine and association with halofantrine, mefloquine or other new antimalarial agents." | 2.41 | [Epidemiological and therapeutic aspects of plasmodial infection from Plasmodium vivax]. ( Granier, H; Klotz, F; Martin, J; Nicolas, X, 2000) |
| " The latter is defined as regular intake of antimalarial drugs in subtherapeutic dosage in order to suppress the development of clinical disease." | 2.41 | [Malaria--chemoprophylaxis 2001]. ( Beck, B; Blum, J; Funk, M; Furrer, H; Genton, B; Hatz, FR; Holzer, B; Loutan, L; Markwalder, K; Raeber, PA; Schlagenhauf, P; Siegl, G; Steffen, R; Stürchler, D; Wyss, R, 2001) |
| "Chloroquine is still the treatment of choice in most cases of P." | 2.39 | [Current malaria management in Switzerland]. ( Hatz, CF, 1994) |
| "Symptoms of malaria are fever, chills, headache, and malaise." | 2.39 | The treatment of malaria. ( White, NJ, 1996) |
| "Amodiaquine was significantly more effective than chloroquine, with odds ratios and 99% confidence intervals (OR [99% CI]) of 4." | 2.39 | Systematic review of amodiaquine treatment in uncomplicated malaria. ( Brasseur, P; Garner, P; LeBras, J; Mussano, P; Nevill, C; Olliaro, P; Ringwald, P, 1996) |
| "Amodiaquine is a pro-drug for the active antimalarial metabolite desethylamodiaquine." | 2.39 | Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications. ( Krishna, S; White, NJ, 1996) |
| "In both areas, malaria is stable and the inhabitants acquire a high immunity before the age of ten; most of the severe cases touch children below 10." | 2.38 | [Epidemiological stratification of malaria in Madagascar]. ( Aknouche, F; Blanchy, S; Laventure, S; Mouchet, J; Rajaonarivelo, E; Rakotonjanabelo, A; Ranaivoson, G; Rossella, M, 1993) |
| "Chloroquine has been the mainstay of antimalarial treatment for the past 40 years, but resistance in P." | 2.38 | Clinical malaria in the tropics. ( Pukrittayakamee, S; White, NJ, 1993) |
| "Malaria is the most important emergency in people returning from tropical countries." | 2.38 | [Malaria: the most important emergency in subjects returning from the tropics]. ( Schubarth, P, 1993) |
| " A model-informed strategy based on preclinical data, which incorporates pharmacokinetic-pharmacodynamic (PK-PD) properties with physiologically based pharmacokinetic (PBPK) modeling, is proposed to optimally predict an efficacious human dose and dosage regimen for the treatment of Plasmodium falciparum malaria." | 1.91 | Integrating Pharmacokinetic-Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study. ( Chibale, K; Gibhard, L; Mulubwa, M; Redhi, D, 2023) |
| " Conversely, when the W2 systems were dosed with chloroquine, parasitemia levels were moderately decreased when compared to the 3D7 model." | 1.91 | Development of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation. ( Comiter, B; Hickman, JJ; Long, CJ; McAleer, CW; Rupar, MJ; Sasserath, T; Smith, E; Sriram, N, 2023) |
| " Drug sensitivity against a panel of antimalarials, the ring-stage survival assay (RSA), the PPQ survival assay (PSA), and bimodal dose-response curves were used to evaluate antimalarial susceptibility." | 1.72 | A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility. ( Boonyalai, N; Griesenbeck, JS; Kirativanich, K; Praditpol, C; Thamnurak, C; Vesely, BA; Waters, NC; Wojnarski, M, 2022) |
| "Malaria is a major health problem in Peru despite substantial progress achieved by the ongoing malaria elimination program." | 1.72 | Drug resistance and population structure of Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon. ( Barazorda, K; Braga, G; Delgado-Ratto, C; Gamboa, D; Joya, CA; Lizewski, SE; Lucas, C; Nolasco, O; Ricopa, L; Salas, CJ; Sanchez, JF; Valdivia, HO; Villena, FE, 2022) |
| "Chloroquine (CQ) has been used for decades as the primary chemotherapeutic drug for the treatment of malaria." | 1.51 | In silico modeling of Plasmodium falciparum chloroquine resistance transporter protein and biochemical studies suggest its key contribution to chloroquine resistance. ( Antony, HA; Gummadi, SN; Krishna, R; Parija, SC; Siva Sankar, D; Topno, NS, 2019) |
| "The therapeutic efficacy study for treating falciparum malaria was complemented with molecular analysis for artemisinin and piperaquine resistance, and in vitro drug susceptibility testing." | 1.51 | Susceptibility of Plasmodium falciparum to artemisinins and Plasmodium vivax to chloroquine in Phuoc Chien Commune, Ninh Thuan Province, south-central Vietnam. ( Birrell, GW; Chavchich, M; Chuang, I; Edstein, MD; Manh, ND; Martin, NJ; Phong, NC; Quang, HH; San, NN, 2019) |
| " Thus, we are in dire need of alternate chemotherapeutic agents which in combination with artemisinin (or its analogues) are efficacious against chloroquine-resistant strains." | 1.51 | In vitro synergistic interaction of potent 4-aminoquinolines in combination with dihydroartemisinin against chloroquine-resistant Plasmodium falciparum. ( Agarwal, D; Awasthi, SK; Gupta, RD; Singh, S, 2019) |
| "Chloroquine (CQ) treatment failure in Plasmodium falciparum parasites has been documented for decades, but the pharmacological explanation of this phenotype is not fully understood." | 1.48 | Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasites. ( Friedrich, O; Geary, TG; Krohne, G; Reiling, SJ; Rohrbach, P, 2018) |
| "Chloroquine is a previously cheap and effective antimalarial agent whose loss to resistance resulted in more than doubling of malaria-related mortality in malaria-endemic countries." | 1.48 | Prevalence of chloroquine resistance alleles among Plasmodium falciparum parasites in countries affected by malaria disease since change of treatment policy: a systematic review protocol. ( Akena, D; Kamya, MR; Kinengyere, AA; Nsobya, S; Obuku, EA; Ocan, M; Senono, R, 2018) |
| "Chloroquine (CQ) was one of the first drugs used for its treatment, but was officially withdrawn from the market in 2007 following reports of high levels of chloroquine resistance." | 1.48 | Low rates of Plasmodium falciparum Pfcrt K76T mutation in three sentinel sites of malaria monitoring in Côte d'Ivoire. ( Amiah-Droh, M; Bédia-Tanoh, VA; Gnagne, PA; Ignace Eby Menan, H; Konaté, A; Tano, DK; Yavo, W, 2018) |
| "Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates." | 1.48 | Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea. ( Fukuda, N; Hirai, M; Hombhanje, F; Ikeda, M; Mita, T; Mori, T; Sekihara, M; Tachibana, SI; Tiwara, S; Yamauchi, M; Yatsushiro, S, 2018) |
| " It was nongenotoxic in an Ames assay, an in vitro micronucleus assay, and an in vivo rat micronucleus assay when dosed orally up to 2000 mg/kg." | 1.46 | Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate. ( Berry, P; Campo, B; Cao, J; Ciaravino, V; Easom, EE; Erve, JCL; Freund, YR; Gamo, FJ; Guo, D; Jacobs, RT; Plattner, JJ; Rosenthal, PJ; Sanz, LM; Zhang, YK, 2017) |
| "The burden of falciparum malaria is especially high in sub-Saharan Africa." | 1.46 | Pooled-DNA sequencing identifies genomic regions of selection in Nigerian isolates of Plasmodium falciparum. ( Amambua-Ngwa, A; Awolola, TS; Idowu, ET; Olukosi, YA; Oyebola, KM, 2017) |
| "Despite extensive use and accumulated evidence of safety, there have been few pharmacokinetic studies from which appropriate chloroquine (CQ) dosing regimens could be developed specifically for pregnant women." | 1.46 | Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling. ( Baiwog, F; Davis, TME; Ilett, KF; Karunajeewa, HA; Kose, K; Mueller, I; Page-Sharp, M; Rogerson, SJ; Salman, S; Siba, PM, 2017) |
| "Chloroquine (CQ) was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance." | 1.46 | Return of chloroquine sensitivity to Africa? Surveillance of African Plasmodium falciparum chloroquine resistance through malaria imported to China. ( Cao, J; Cao, Y; Culleton, RL; Gao, Q; Gu, Y; He, X; Li, J; Liu, Y; Lu, F; Tang, J; Wang, W; Xu, S; Zhang, C; Zhang, M; Zhou, H; Zhu, G, 2017) |
| "falciparum malaria were included in the study and followed until day 28 after having taken 25 mg/kg of chloroquine orally over 3 days." | 1.46 | In vivo study of Plasmodium falciparum chloroquine susceptibility in three departments of Haiti. ( Boncy, J; Brasseur, P; Cicéron, M; Parke, DM; Raccurt, CP; Zervos, MJ, 2017) |
| "Chloroquine is an antimalarial agent with strong activity against the blood stage of Plasmodium infection, but with low activity against the parasite's liver stage." | 1.46 | Platinum(ii)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function. ( Batista, AA; Couto, CC; Macedo, TS; Machado, M; Moreira, DRM; Navarro, M; Prudêncio, M; Soares, MBP; Villarreal, W, 2017) |
| "The treatment with chloroquine or cercosporin of the parasites increased the ratio between α-tocopherolquinone and α-tocopherol." | 1.46 | Plasmodium falciparum uses vitamin E to avoid oxidative stress. ( Fotoran, WL; Katzin, AM; Kimura, EA; Sussmann, RAC, 2017) |
| "Chloroquine treatment possibly resulted in the development of pfcrt 72-76 CVIET." | 1.46 | Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976-78. ( Björkman, A; Jovel, IT; Mårtensson, A; Roper, C; Ursing, J, 2017) |
| " Compounds with halogen substitutions displayed sustained plasma levels after oral dosing in rodents leading to efficacy in the P." | 1.43 | Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. ( Angulo-Barturen, I; Bazaga, SF; Burrows, JN; Charman, SA; Chen, G; Coteron, JM; de Las Heras, L; Deng, X; El Mazouni, F; Jimenez-Diaz, MB; Kaminsky, W; Kokkonda, S; Leroy, D; Manjalanagara, K; Marco, M; Martínez-Martínez, MS; Matthews, D; Morizzi, J; Phillips, MA; Rathod, PK; Rudra, KR; Ryan, E; Tomchick, DR; Waterson, D; White, J; White, KL, 2016) |
| " The most promising compound (13) showed a reduction in parasitemia of 96% when dosed at 30 mg/kg orally once a day for 4 days in the P." | 1.43 | Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. ( Angulo-Barturen, I; Avery, VM; Baragaña, B; Campbell, SF; Duffy, S; Fairlamb, AH; Ferrer, S; Frearson, JA; Gamo, FJ; Gilbert, IH; Gray, DW; Grimaldi, R; Hallyburton, I; Jiménez-Díaz, B; Martínez, MS; Meister, S; Norcross, NR; Norval, S; Osuna-Cabello, M; Porzelle, A; Read, KD; Riley, J; Sanz, L; Simeons, FR; Stojanovski, L; Waterson, D; Willis, P; Wilson, C; Winzeler, EA; Wittlin, S, 2016) |
| "Chloroquine (CQ) has been used for malaria treatment in Haiti for several decades, but reports of CQ resistance are scarce." | 1.42 | Therapeutic efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum in Haiti after many decades of its use. ( de Rochars, MB; Existe, A; Fukuda, M; Memnon, G; Okech, BA; Romain, JR; Victor, YS, 2015) |
| "Chloroquine failure rate was high which was well above the WHO recommended cut off threshold for drug policy change (> 10%), Sulfadoxine- Pyrimethamine can be used in place of Chloroquine as the first line drug in uncomplicated P." | 1.42 | Comparative Study of Effectiveness and Resistance Profile of Chloroquine and Sulfadoxine-Pyrimethamine in Uncomplicated Plasmodium falciparum Malaria in Kolkata. ( Basu, A; Guha, SK; Saha, S, 2015) |
| " Furthermore, 35 displayed high (78%) rat oral bioavailability with good oral exposure and plasma half-life." | 1.40 | Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1. ( Avery, VM; Charman, SA; Chibale, K; Douelle, F; Duffy, S; Gonzàlez Cabrera, D; Le Manach, C; March, C; Nchinda, AT; Ryan, E; Street, LJ; Taylor, D; Waterson, D; White, KL; Wiesner, L; Wittlin, S; Witty, MJ; Younis, Y, 2014) |
| "vivax malaria is a substantial risk." | 1.40 | Imported malaria is stable from Africa but declining from Asia. ( David, K; Møller, CH, 2014) |
| " Moreover, an oral bioavailability of 40% for compound 50 was determined from in vivo pharmacokinetic studies." | 1.39 | Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. ( Diao, Y; Han, D; Huang, J; Li, H; Ren, X; Sun, D; Xu, M; Xu, Y; Zhao, Z; Zhou, H; Zhu, J; Zhu, L, 2013) |
| " We reasoned that, akin to antibacterials, antimalarials might have an essential pharmacokinetic requirement for efficacy: action governed either by total exposure or peak concentration (AUC/CMAX), or by duration above a defined minimum concentration [time above minimum inhibitory concentration (TMIC)]." | 1.39 | Model system to define pharmacokinetic requirements for antimalarial drug efficacy. ( Bakshi, RP; Nenortas, E; Shapiro, TA; Sullivan, DJ; Tripathi, AK, 2013) |
| "Chloroquine (CQ) was the main malaria therapy worldwide from the 1940s until the 1990s." | 1.39 | Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011. ( Aboubaca, A; Agnamey, P; Aiach, MM; Angoulvant, A; Barbut, P; Basset, D; Belkadi, G; Bellanger, AP; Bemba, D; Benoit-Vica, F; Berry, A; Bertaux, L; Bigel, ML; Bonhomme, J; Botterel, F; Bouchaud, O; Bougnoux, ME; Bourée, P; Bourgeois, N; Branger, C; Bret, L; Buret, B; Casalino, E; Chevrier, S; Conquere de Monbrison, F; Cuisenier, B; Danis, M; Darde, ML; De Gentile, L; Delarbre, JM; Delaunay, P; Delaval, A; Desoubeaux, G; Develoux, M; Dunand, J; Durand, R; Eloy, O; Fauchet, N; Faugere, B; Faye, A; Fenneteau, O; Flegg, JA; Flori, P; Fontrouge, M; Garabedian, C; Gayandrieu, F; Gharbi, M; Godineau, N; Guérin, PJ; Houzé, P; Houzé, S; Hubert, V; Hurst, JP; Ichou, H; Kendjo, E; Lachaud, L; Le Bras, J; Le Moal, G; Lebuisson, A; Lefevre, M; LeGuern, AS; Lusina, D; Machouart, MC; Malvy, D; Matheron, S; Maubon, D; Mechali, D; Megarbane, B; Menard, G; Metcalf, JE; Millon, L; Minodier, P; Morelle, C; Nevez, G; Parola, P; Parzy, D; Patey, O; Patoz, P; Penn, P; Perignon, A; Picot, S; Pilo, JE; Poilane, I; Pons, D; Poupart, M; Pradines, B; Raffenot, D; Rapp, C; Receveur, MC; Sarfati, C; Senghor, Y; Simon, F; Siriez, JY; Taudon, N; Thellier, M; Thouvenin, M; Toubas, D, 2013) |
| "Chloroquine (CQ) drug was withdrawn in 1998 as a first-line treatment of uncomplicated malaria in Kenya." | 1.38 | Changes in genotypes of Plasmodium falciparum human malaria parasite following withdrawal of chloroquine in Tiwi, Kenya. ( Mang'era, CM; Mbai, FN; Mireji, PO; Omar, SA; Omedo, IA, 2012) |
| " The treatment of malaria in young children and the relative benefits of age- and weight-based dosing need further exploration." | 1.38 | Monitoring antimalarial drug resistance in India via sentinel sites: outcomes and risk factors for treatment failure, 2009-2010. ( Anvikar, AR; Arora, U; Bhatt, RM; Das, MK; Dhariwal, AC; Ghosh, SK; Gupta, R; Kaitholia, K; Kumar, A; Mishra, N; Shah, NK; Sharma, SK; Singh, JP; Sonal, GS; Srivastava, B; Valecha, N, 2012) |
| " Nanosized carriers have been receiving special attention with the aim of minimizing the side effects of malaria therapy by increasing drug bioavailability and selectivity." | 1.37 | A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro. ( Cortés, A; Estelrich, J; Fernàndez-Busquets, X; Urbán, P, 2011) |
| "Plasmodium falciparum malaria is endemic in Haiti, but epidemiological data are scarce." | 1.37 | Malaria among patients and aid workers consulting a primary healthcare centre in Leogane, Haiti, November 2010 to February 2011 - a prospective observational study. ( Garpenfeldt, K; Held, K; Neuberger, A; Pex, R; Schwartz, E; Tenenboim, S; Urman, M; Vernet, S; Zaulan, O, 2011) |
| "Chloroquine treatment was not efficacious, and of 93 assessable patients, only 10 individuals (10." | 1.36 | Dynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparum. ( El-Sayed, B; Elzaki, SE; Gadalla, NB; Mukhtar, E; Sutherland, CJ; Warhurst, DC, 2010) |
| "falciparum malaria were recruited and treated with CQ+SP." | 1.36 | Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology. ( Ballif, M; Beck, HP; Crameri, A; Fafale, A; Felger, I; Genton, B; Hii, J; Marfurt, J, 2010) |
| "Chloroquine treatment failures were significantly associated with Pfmdr-1 86Y mutant codon (OR = 4." | 1.36 | Chloroquine clinical failures in P. falciparum malaria are associated with mutant Pfmdr-1, not Pfcrt in Madagascar. ( Andriantsoanirina, V; Bouchier, C; Durand, R; Jahevitra, M; Ménard, D; Mercereau-Puijalon, O; Rabearimanana, S; Raherinjafy, R; Ratsimbasoa, A; Tichit, M, 2010) |
| "Ellagic acid is a polyphenol found in various plant products." | 1.35 | In vitro and in vivo properties of ellagic acid in malaria treatment. ( Benoit-Vical, F; Berry, A; Garcia-Alvarez, MC; Nicolau, ML; Olagnier, D; Soh, PN; Witkowski, B, 2009) |
| "1%) were the three main molecules which account for antimalarial self-treatment However the use of these molecules was inappropriate regarding the dosage (41." | 1.35 | [Self-medication in the treatment of acute malaria: study based on users of private health drug stores in Ouagadougou, Burkina Faso]. ( Diarra, M; Guissou, IP; Ouédraogo, LT; Somé, IT, 2008) |
| "falciparum malaria was evaluated in the Anand district of Gujarat state, in western India." | 1.35 | Therapeutic responses of Plasmodium vivax and P. falciparum to chloroquine, in an area of western India where P. vivax predominates. ( Dash, AP; Joshi, H; Mallick, PK; Prajapati, SK; Srivastava, HC; Valecha, N; Yadav, RS, 2008) |
| "Chloroquine resistance has been associated with the Plasmodium falciparum multidrug resistance 1 (Pfmdr1) mutant gene." | 1.35 | High prevalence of Plasmodium falciparum Pfmdr1 86Y mutant gene in sickle cell disease in Nigeria. ( Agbonlahor, DE; Clarence, YS; Faith, O; Inoigbe, OP; Mirabeau, TY; Samuel, TK, 2008) |
| "Parasite recrudescences in 33 consecutive paired episodes during the same pregnancy were identified by msp1 and msp2 genotyping." | 1.35 | Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women. ( Alonso, PL; Aponte, JJ; Bardají, A; Cisteró, P; Mandomando, I; Mayor, A; Menéndez, C; Puyol, L; Sanz, S; Serra-Casas, E; Sigauque, B, 2009) |
| "Chloroquine was the main drug used in treatment of malaria throughout the periods studied, with frequency of prescription at both sites ranging from 91." | 1.35 | Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy. ( Ganiyu, A; Gbotosho, GO; Happi, CT; Oduola, AM; Ogundahunsi, OA; Sowunmi, A, 2009) |
| "Chloroquine resistance has been associated with the emergence of Pfcrt mutant genes." | 1.35 | Chloroquine prophylaxis associated with high prevalence of Plasmodium falciparum pfcrt K76T mutation in people with sickle-cell disease in Benin City, Nigeria. ( Adeolu, A; Agbonlahor, DE; Okodua, M; Omolu, PI; Tatfeng, YM; Tchounga, KS; Yah, CS, 2008) |
| "Chloroquine was provided free of charge to all fever cases." | 1.35 | Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India. ( Das, LK; Jambulingam, P; Sadanandane, C, 2008) |
| " We investigated whether the in vivo efficacy of chloroquine (CQ) in children aged 6-59 months with uncomplicated malaria differed in 9 villages that had benefited from long-term use of insecticide-treated curtains (ITCs) and in 9 nearby non-ITC villages." | 1.34 | Sustained use of insecticide-treated curtains is not associated with greater circulation of drug-resistant malaria parasites, or with higher risk of treatment failure among children with uncomplicated malaria in Burkina Faso. ( Cousens, SN; Diallo, DA; Greenwood, BM; Ilboudo-Sanogo, E; Konaté, AT; Nebié, I; Ord, R; Pota, H; Roper, C; Sutherland, C, 2007) |
| "Chloroquine (CQ) has been in use in Africa for a long time." | 1.34 | Rapid detection of Pfcrt and Pfmdr1 mutations in Plasmodium falciparum isolates by FRET and in vivo response to chloroquine among children from Osogbo, Nigeria. ( Fagbenro-Beyioku, AF; Fendel, R; Kremsner, PG; Kun, JF; Ogungbamigbe, TO; Ojurongbe, O, 2007) |
| "Chloroquine has been the first line drug of treatment for malaria in Zimbabwe until a recent adoption of an interim policy to treat using a combination of chloroquine (CQ) and sulfadoxine/pyrimethamine (SP)." | 1.34 | High prevalence of molecular markers for resistance to chloroquine and pyrimethamine in Plasmodium falciparum from Zimbabwe. ( Chivenga, J; Gemperli, A; Kumar, N; Mbedzi, J; Mlambo, G; Mutambu, SL; Soko, W; Sullivan, D, 2007) |
| "The main clinical features concerning cerebral malaria, diagnostic tools and therapeutic measures are discussed." | 1.33 | [Imported cerebral malaria]. ( Guillon, B; Maiga, Y; Yatim, D, 2005) |
| "Falciparum Malaria is hyperendemic in southern Nigeria and chloroquine resistance is an increasing problem." | 1.33 | Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine. ( Göbels, K; Graupner, J; Grobusch, MP; Häussinger, D; Lund, A; Richter, J, 2005) |
| "Chloroquine resistance was measured by the in vitro microtest recommended by WHO." | 1.33 | [The point mutations in Pfcrt and Pfmdr1 genes in Plasmodium falciparum isolated from Hainan Province]. ( Feng, XP; Guan, YY; Hu, L; Liu, DQ; Tang, LH, 2005) |
| "Chloroquine treatment remains the most common single treatment of malaria in sub-Saharan Africa." | 1.33 | Chloroquine-induced bilateral ptosis. ( Bedu-Addo, G, 2006) |
| "Sulfadoxine-pyremethamine treatment alone cured 68." | 1.33 | The efficacy of sulfadoxine-pyrimethamine alone and in combination with chloroquine for malaria treatment in rural Eastern Sudan: the interrelation between resistance, age and gametocytogenesis. ( A-Elbasit, IE; Alifrangis, M; Elbashir, MI; Giha, HA; Khalil, IF, 2006) |
| "Amodiaquine use has increased in the region." | 1.33 | Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania. ( Alifrangis, M; Bygbjerg, IC; Dalgaard, MB; Enevold, A; Jensen, AT; Khalil, IF; Lemnge, MM; Lusingu, JP; Rønn, AM; Staalsoe, T; Theander, TG; Vestergaard, LS; Warhurst, DC, 2006) |
| " Patients were treated with standard dosage of CQ and followed up for 28 days." | 1.33 | Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria. ( Bolaji, OM; Fateye, BA; Folarin, OA; Gbotosho, GO; Happi, CT; Kyle, DE; Milhous, W; Oduola, AM; Sowunmi, A; Wirth, DF, 2006) |
| "Treatment with quinine dihydrochloride i." | 1.33 | [Successful management of malaria tropica with 50% parasitaemia]. ( Eiffert, H; Möller, H; Ramadori, G; Reichard, U; Schwörer, H, 2006) |
| "Amodiaquine was effective at all study sites (proportion of failures, 7." | 1.33 | Molecular epidemiology of malaria in Cameroon. XXI. Baseline therapeutic efficacy of chloroquine, amodiaquine, and sulfadoxine-pyrimethamine monotherapies in children before national drug policy change. ( Abodo, RT; Basco, LK; Ndounga, M; Ngane, VF; Same-Ekobo, A; Soula, G; Youmba, JC, 2006) |
| "Ferroquine is a derivative of chloroquine and shows good activity in vitro and in animal models, but the development of cross-resistance is of concern." | 1.33 | In vitro activity of ferroquine (SAR97193) is independent of chloroquine resistance in Plasmodium falciparum. ( Dietz, K; Kreidenweiss, A; Kremsner, PG; Mordmüller, B, 2006) |
| "Chloroquine treatment mediated oxidative stress in the host and this effect was exacerbated in Plasmodium falciparum infected patients administered with the drug." | 1.32 | Influence of chloroquine treatment and Plasmodium falciparum malaria infection on some enzymatic and non-enzymatic antioxidant defense indices in humans. ( Emerole, GO; Farombi, EO; Shyntum, YY, 2003) |
| "Chloroquine resistance was seen in 23% of the cases." | 1.32 | Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal community. ( Chand, SK; Mishra, AK; Shukla, MM; Singh, N, 2003) |
| "The first treatment of malaria in 2000 was monotherapy with quinine (P." | 1.32 | [Imported malaria in 2000 in 2 northern Paris hospitals]. ( Bouchaud, O; Durand, R; Godineau, N; Hamane, S; Keundjian, A; Le Bras, J; Ralaimazava, P, 2003) |
| "Chloroquine resistant was increased with the decrease of education level; decrease income/capita/month; among younger age-group (<15 years); and sleeping in open air in courts (56." | 1.32 | Malaria status in Al-Hodeidah Governorate, Republic of Yemen. Part II: Human factors causing the persistence of chloroquine resistant P. falciparum local strain. ( Al-Maktari, MT; Bassiouny, HK, 2003) |
| " Preliminary studies of the pharmacodynamic activity of this newly synthesized compound revealed that at the doses which exhibit potent antimalarial activity, there is no alteration in motor activity such as distance traveled, rotational behavior, and stereotypic activity." | 1.32 | The pharmacodynamic study of a potent new antimalarial (MC1). ( Khamkong, P; Pavaro, C; Ruchirawat, S; Satayavivad, J; Tuntawiroon, J; Watcharasit, P, 2004) |
| "falciparum malaria were initially treated with chloroquine (CQ)." | 1.32 | Therapeutic efficacies of antimalarial drugs in the treatment of uncomplicated, Plasmodium falciparum malaria in Assam, north-eastern India. ( Barman, K; Dev, V; Phookan, S, 2003) |
| "Chloroquine has been widely used for malaria treatment and prophylaxis for several decades, but its usefulness has now declined with the emergence of chloroquine resistance." | 1.32 | Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro. ( Beaudou, J; Berry, A; Durrand, V; Fandeur, T; Glaziou, P; Sem, R, 2004) |
| "Chloroquine effectiveness was associated with age and ethnicity." | 1.32 | Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso. ( Kouyate, B; Mueller, O; Razum, O; Traore, C, 2004) |
| "Chloroquine was administered in accordance with the standard 14 day WHO protocol; i." | 1.32 | [Revaluation of chloroquine therapeutic efficacy on children with uncomplicated Plasmodium falciparum malaria in eastern Ivory Coast (1999-2002)]. ( Adou, SJ; Adoubryn, KD; Assoumou, A; Kouabenan, A; Kouakou, KA; N'guettia, KS; Ouhon, J; Yapo, CG, 2004) |
| "Chloroquine treatment failed in 23 children (76." | 1.32 | Plasmodium falciparum resistant to chloroquine and to pyrimethamine in Comoros. ( Ariey, F; Bedja, SA; Mercereau-Puijalon, O; Migliani, R; Raherinjafy, RH; Randrianarivelojosia, M, 2004) |
| "Chloroquine resistance was only checked in the subjects harboring P." | 1.32 | Chloroquine resistance and Plasmodium falciparum in Punjab, Pakistan during 2000-2001. ( Rana, MS; Tanveer, A, 2004) |
| "falciparum malaria was diagnosed using microscopic methods." | 1.32 | Assessment of clinical course and outcome of Plasmodium falciparum malaria in Angola diagnosed by microscopic and molecular methods. ( Kryger, T; Myjak, P; Nahorski, W; Pietkiewicz, H; Szostakowska, B; Wojtacha, A, 2004) |
| "Oral chloroquine is the treatment of choice for uncomplicated Plasmodium malariae infections worldwide." | 1.31 | Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. ( Baird, JK; Bangs, MJ; Laksana, B; Maguire, JD; Mahmud, N; Masbar, S; Prodjodipuro, P; Sismadi, P; Sumawinata, IW; Susanti, I, 2002) |
| "Chloroquine resistance has been linked to mutations in the pfcrt and pfmdr1 genes of Plasmodium falciparum." | 1.31 | In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal. ( Dieng, T; Maguire, JH; Mboup, S; Ndir, O; Thomas, SM; Wirth, DF; Wypij, D, 2002) |
| "Chloroquine treatment resulted in clinical failure in 33% (n = 60) and 51% (n = 49) of the patients in Merca and Gabiley respectively." | 1.31 | Therapeutic efficacy of chloroquine and sulfadoxine/pyrimethamine against Plasmodium falciparum infection in Somalia. ( Abdillahi, A; Duale, ON; Hassan, AM; Ismail, AN; Mohamed, A; Warsame, A; Warsame, M, 2002) |
| "Chloroquine resistance was observed in > 70% of the isolates from Africa and India followed by Pakistan (39." | 1.31 | Drug-resistant Plasmodium falciparum infection in immigrants and non-immune travellers. ( Al-Aniezi, A; Hira, PR; Lqbal, J; Sher, A, 2002) |
| "Chloroquine was thus an ineffective therapy for P." | 1.31 | Chloroquine or sulfadoxine-pyrimethamine for the treatment of uncomplicated, Plasmodium falciparum malaria during an epidemic in Central Java, Indonesia. ( Baird, JK; Bangs, MJ; Barcus, MJ; Basuki, W; Edstein, MD; Lacy, MD; Laksana, B; Maguire, JD; Marwoto, H; Masbar, S; Sismadi, P; Susanti, I; Tjokrosonto, S; Wiady, I, 2002) |
| "Chloroquine was administered on a dosage of 25 mg/kg, spread over three days." | 1.31 | [Therapeutic efficacy of chloroquine in the uncomplicated malaria due to Plasmodium falciparum in hospital patients in central Ivory Coast (1997-2000)]. ( Adou-Bryn, KD; Akoussi, CF; Assoumou, A; Boni, NM; Ehouman, A; Krelo, K; Ouhon, J; Penali, LK; Yapo, GC, 2002) |
| "Amodiaquine was 3." | 1.31 | In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar. ( Ariey, F; Duchemin, JB; Harisoa, JL; Mauclere, P; Pietra, V; Rabarijaona, LP; Raharimalala, LA; Rakotomanana, F; Ranaivo, L; Randrianarivelojosia, M; Robert, V, 2002) |
| "Pyronaridine was the most effective gametocytocidal drug against P." | 1.31 | Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro. ( Auparakkitanon, S; Chavalitshewinkoon-Petmitr, P; Pongvilairat, G; Wilairat, P, 2000) |
| " From September to December 1998, 598 children with uncomplicated malaria were treated; 135 received chloroquine (CQ) alone, 276 received pyrimethamine/sulfadoxine (Fansidar, PSD) alone, 113 received PSD with a single dose of artesunate (PSD + 1ART) and 74 received PSD combined with three doses of artesunate (PSD + 3ART)." | 1.31 | Parasitaemia and gametocytaemia after treatment with chloroquine, pyrimethamine/sulfadoxine, and pyrimethamine/sulfadoxine combined with artesunate in young Gambians with uncomplicated malaria. ( Coleman, R; Doherty, T; Jawara, M; Targett, G; von Seidlein, L; Walraven, G, 2001) |
| "Ferrochloroquine was active against P." | 1.31 | Ferrocene-chloroquine analogues as antimalarial agents: in vitro activity of ferrochloroquine against 103 Gabonese isolates of Plasmodium falciparum. ( Daries, W; Fusai, T; Kombila, M; Laloge, V; Millet, P; Panconi, E; Parzy, D; Pradines, B; Rogier, C, 2001) |
| "Amodiaquine was shown to be more effective than chloroquine in clinical response and ridding patients of parasites: adequate clinical response was significantly higher with amodiaquine than chloroquine [100% (27/27) versus 45% (9/20), p < 0." | 1.31 | [Evaluation of efficacy and tolerance of amodiaquine versus chloroquine in the treatment of uncomplicated malaria outbreak in children of Gabon]. ( Bouyou Akotet, M; Guiyedi, V; Koko, J; Kombila, M; Mabika Manfoumbi, M; Matsiégui, PB; Traoré, B, 2001) |
| " The dose-response relationship between the severity of parasitaemia and the risk of being anaemic (P < 0." | 1.31 | Weekly chloroquine prophylaxis and the effect on maternal haemoglobin status at delivery. ( Bosny, JP; Dagne, G; Naik, EG; Salihu, HM; Tchuinguem, G, 2002) |
| "Gedunin was extracted in quantity, and nine derivatives prepared for a structure-activity study, which revealed essential functionalities for activity." | 1.30 | Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives. ( Angerhofer, C; Arnason, JT; Durst, T; Gbeassor, M; MacKinnon, S; Pezzuto, J; Poveda, LJ; Sanchez-Vindas, PE, 1997) |
| "vivax parasitemias were sensitive to chloroquine and the blood remained clear, with the exception of one case in which an asymptomatic parasitemia appeared on day 28." | 1.30 | Survey of in vivo sensitivity to chloroquine by Plasmodium falciparum and P. vivax in Lombok, Indonesia. ( Baird, JK; Candradikusuma, D; Fryauff, DJ; Leksana, B; Marwoto, H; Masbar, S; Richie, T; Romzan, A; Sutamihardja, MA; Tuti, S, 1997) |
| " This malaria parasite was sensitive to standard dosage of either chloroquine or sulphadoxine-pyrimethamine." | 1.30 | Malaria in Mvumi, central Tanzania and the in vivo response of Plasmodium falciparum to chloroquine and sulphadoxine pyrimethamine. ( Mboera, LE; Ndawi, BT; Wakibara, JV, 1997) |
| "Artemether was equally effective on chloroquine-sensitive and chloroquine-resistant isolates (mean IC50 = 346 nM, 95% CI = 2." | 1.30 | In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs. ( Doury, JC; Fusai, T; Pradines, B; Rogier, C; Tall, A; Trape, JF, 1998) |
| "Chloroquine was prescribed at 25 mg/kg for 3 days in asymptomatic Brazzavillian school children who presented parasitemia > 800 P." | 1.30 | [No variation in chloroquine resistance (Plasmodium falciparum) from 1986 to 1996 in semi-immune children in Brazzaville (Congo)]. ( Baya Tsika, N; Carme, B; Kissila, AM; Ndounga, M; Samba, G, 1998) |
| "One case of cerebral malaria was noted." | 1.30 | [Malaria in an urban environment: the case of the city of Rufisque in Senegal]. ( Diallo, S; Dieng, Y; Faye, O; Feller-Dansokho, E; Gaye, O; Lakh, NC; Ndir, O, 1997) |
| "Chloroquine therefore has declining parasitological and clinical value as the first-line, presumptive treatment for uncomplicated, falciparum malaria in the study area, necessitating strategies to cope with resistant cases." | 1.30 | Status of chloroquine efficacy against falciparum malaria in the Mola area of Kariba district, Zimbabwe. ( Chandiwana, SK; Mharakurwa, S; Murahwa, FC; Rangarira, R, 1998) |
| "Pyronaridine was less potent against chloroquine-resistant isolates than chloroquine-susceptible isolates but more potent than chloroquine against chloroquine-resistant parasites." | 1.30 | In vitro susceptibility of African isolates of Plasmodium falciparum from Gabon to pyronaridine. ( Doury, JC; Kombila, M; Lebeau, C; Mabika Mamfoumbi, M; Mourou Mbina, JR; Owono Medang, M; Parzy, D; Pradines, B, 1999) |
| "Treatment with halofantrine was successful in all but one case which required combined chemotherapy using quinine and doxycycline." | 1.30 | [Health assessments of a military company stationed on the Maroni River in French Guiana]. ( Lial, JP, 1999) |
| "Chloroquine failure was found in 43% of the children." | 1.30 | Current clinical efficacy of chloroquine for the treatment of Plasmodium falciparum infections in urban Dar es Salaam, United Republic of Tanzania. ( Makwaya, C; Minjas, JN; Premji, Z, 1999) |
| "Chloroquine was prescribed at 25 mg/kg for 3 days in febrile patients with uncomplicated P." | 1.30 | [Chloroquine sensitivity of Plasmodium falciparum at the Gamkalley Clinic and the Nigerian armed forces PMI (Niamey, Niger)]. ( Ali, I; Bendavid, C; Condomines, P; Crassard, N; Djermakoye, F; Faugère, B; Parola, P, 1999) |
| "Chloroquine was undetectable in plasma samples of 8 out of 55 P." | 1.30 | Chloroquine concentration profile in the community of Mewat region, district Gurgaon (Haryana), India. ( Dua, VK; Gupta, NC; Sharma, VP, 1999) |
| "falciparum malaria are to be treated with chloroquine, rigorous monitoring for nonresponse and timely rescue medication is necessary." | 1.30 | Resurgence of malaria in Mumbai--is escalating chloroquine resistance a cause? ( Bodhe, PV; Garg, MR; Gogtay, NJ; Kotwani, RN; Kshirsagar, NA, 1999) |
| "The prevalence of enlarged spleen was 57% in children and 10% in adults and closely matched the corresponding age-related parasite rate." | 1.29 | The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity. ( al-Yaman, F; Alpers, MP; Beck, HP; Genton, B; Gibson, N; Hii, J; Mellor, S; Narara, A; Smith, T, 1995) |
| "Quinine was used as curative treatment of malaria before admission in a significant greater proportion (p < 0." | 1.29 | An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. ( Delacollette, C; Taelman, H; Wery, M, 1995) |
| "There were 26 cases of cerebral malaria, with a death rate of 34." | 1.29 | [Malaria in children at the Sihanoukville Hospital (Cambodia)]. ( Imbert, P; Martin, YN; Migliani, R; Pheng, S; Sokhan, C; Yen, KK, 1994) |
| "Chloroquine treatment in vivo resulted in parasite clearance in 47 subjects (92." | 1.29 | Susceptibility of Plasmodium falciparum to chloroquine and mefloquine in Ouagadougou area (Burkina Faso). ( Del Nero, L; Lamizana, L; Nebie, I; Pietra, V, 1993) |
| " Dosage was 25 mg/kg chloroquine base delivered over three days." | 1.29 | Chloroquine resistant Plasmodium falciparum in coastal Tanzania. A challenge to the continued strategy of village based chemotherapy for malaria control. ( Minjas, JN; Premji, Z; Shiff, CJ, 1994) |
| "Chloroquine has been the treatment of choice for vivax malaria for more than 40 years." | 1.29 | Vivax malaria resistant to treatment and prophylaxis with chloroquine. ( Andersen, EM; Bangs, MJ; Basri, H; Gorden, J; Harjosuwarno, S; Lal, AA; Mount, DL; Murphy, GS; Purwokusumo, AR, 1993) |
| "He had a single grand mal seizure 37 days following retreatment with quinine intravenously, which resulted in rapid clearance of fever and parasitemia, in addition to mefloquine." | 1.29 | [A case of mefloquine-resistant Plasmodium falciparum malaria with convulsion after antimalarial treatment]. ( Aoki, M; Kamei, K; Miyashita, T; Nishiya, H; Ohyatsu, I; Ono, Y; Shibuya, T; Sugiyama, H; Tokumura, Y; Yamaguchi, M, 1994) |
| "Control of falciparum malaria has become almost impossible in many areas due to the development of resistance to chloroquine and other antimalarial drugs." | 1.29 | Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum. ( Boulter, MK; Bray, PG; Howells, RE; Ritchie, GY; Ward, SA, 1994) |
| "Chloroquine resistance was present in 58." | 1.29 | In vitro responses of P. falciparum parasites to chloroquine, amodiaquine and quinine in two ecological zones in Ghana. ( Afari, EA; Akanmori, BD; Nakano, T; Ofori-Adjei, D, 1993) |
| " The investigations undertaken by the Pasteur Institute of Madagascar, by the Institute for Tropical Medicine and Epidemiology in Paris and by the Unit of Epidemiological Surveillance within the Malagasy Ministry of Health raise a number of questions: Taking to account the various causes for imprecision in measurement and in evaluation (variations in parasite density, microscopic detection levels, bio-availability of the drug) of the groups of R I and R II how significant are the variations observed in numbers and proportions of resistance levels R I and R II? How important are the effects of auto-medication? Can they be correctly evaluated by Bergquist's test? How explain the low level of drug resistance in a country close to East Africa, in which chemoprophylaxis has been widely practiced and in which insufficient dosage for treatment is common? The absence of R III resistance in vivo permit for chloroquine to remain the first line treatment for malaria in Madagascar." | 1.29 | [Evolution of Plasmodium falciparum drug sensitivity in Madagascar from 1982 to 1993 and operational consequences]. ( Blanchy, S; Rakotonjanabelo, A; Ranaivoson, G, 1993) |
| "Of the 134 seizure cases seen, febrile convulsion (FC) formed the majority (55%) with cerebral malaria (CM) as the only major (33%) rival." | 1.29 | Upsurge of malaria-related convulsions in a paediatric emergency room in Nigeria. Consequence of emergence of chloroquine-resistant Plasmodium falciparum. ( Asindi, AA; Ekanem, EE; Ibia, EO; Nwangwa, MA, 1993) |
| "Cyproheptadine and verapamil were not effective in reversing chloroquine resistance and probable drug toxicity was observed with these drugs in combination with chloroquine." | 1.29 | Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys. ( Kyle, DE; Milhous, WK; Rossan, RN, 1993) |
| "Chloroquine was given under supervision at the standard dose of 25 mg kg-1 over three days (days 0, 1 and 2) with an observation period of one hour after treatment." | 1.29 | A national survey of the prevalence of chloroquine resistant Plasmodium falciparum in Burkina Faso. ( Del Nero, L; Lamizana, L; Pietra, V; Rotigliano, G, 1993) |
| "Chloroquine sensitivity was found in 77 (32%) patients." | 1.29 | Falciparum malaria, imported into The Netherlands, 1979-1988. I. Epidemiological aspects. ( de Geus, A; Wetsteyn, JC, 1995) |
| "Artemisinin was rapidly effective against both rings and schizonts, achieving 100% growth inhibition within 6-8 h." | 1.29 | In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs. ( Davis, TM; Johnston, WA; Manning, LS; Skinner, TS, 1996) |
| "Chloroquine was effective in 75% cases despite of existence of resistant falciparum strain." | 1.29 | Epidemiological observations on malaria in villages of Buhari PHC, Surat, Gujarat. ( Bhatt, RM; Kant, R; Sharma, SK; Sharma, VP; Srivastava, HC, 1995) |
| "Treatment failure of chloroquine in standard dosage (25 mg/kg)." | 1.29 | Risk factors of chloroquine resistance in Plasmodium falciparum malaria. ( Cowdrey, D; Hess, FI; Iannuzzi, A; Leafasia, J; Löscher, T; Nothdurft, HD; Rieckmann, KH; Von Sonnenburg, F, 1996) |
| " We administered a drug combination (chloroquine and a tiapamil analogue), that has been shown to reverse chloroquine resistance in vitro, to Aotus monkeys but failed to safely clear experimentally-induced chloroquine-resistant Plasmodium falciparum parasitaemias." | 1.28 | Treatment of chloroquine-resistant malaria in monkeys with a drug combination that reverses resistance in vitro. ( Johnson, DJ; Martin, SK; Okoye, VC; Williams, HL, 1992) |
| "Chloroquine treatments were given at 25 mg/kg over 3 days period to children with P." | 1.28 | Persistence of low levels of Plasmodium falciparum resistance to chloroquine in the autochthonous population of the Central African Republic. ( Capdevielle, H; Courtois, P; Delmont, J; Le Tien, C; Roungou, JB; Testa, J, 1992) |
| " The mean dosage of chloroquine for complete inhibition of schizont formation declined from 10." | 1.28 | [Alteration in resistance of Plasmodium falciparum to chloroquine after cessation of chloroquine medication for twelve years]. ( Cai, XZ; Gao, DQ; Liang, AH; Ling, CF; Liu, DQ; Liu, RJ; Qiu, CP; Ren, DX; Tang, Y; Zhang, CY, 1992) |
| "Chloroquine resistance was detected in 38% of the subjects by thick blood smear and in 45% by the QBC test." | 1.28 | Rapid in vivo detection of chloroquine resistance by the Quantitative Buffy Coat Malaria Diagnosis System. ( Busangu, I; Garin, B; Perrone, J; Peyron, F; Salun, JJ; Vigier, JP, 1992) |
| " In nine of 13 patients who received prophylaxis, there was inadequate dosing or poor compliance." | 1.28 | Imported malaria in the Bronx: review of 51 cases recorded from 1986 to 1991. ( Froude, JR; Tanowitz, HB; Weiss, LM; Wittner, M, 1992) |
| " A dosage of chloroquine base (25 mg/kg of body weight) was given to women over a 3-day period, followed by 5 mg/kg doses administered weekly for 4 weeks." | 1.28 | Malaria and pregnancy in Cameroonian women. Effect of pregnancy on Plasmodium falciparum parasitemia and the response to chloroquine. ( Campbell, CC; James, MA; Mvondo, JL, 1992) |
| "Recrudescence was confirmed by microscopic examination, indicating a type RI resistance to halofantrine." | 1.28 | Type RI resistance to halofantrine in West Africa. ( Basco, LK; Bouchaud, O; Coulaud, JP; Farinotti, R; Gillotin, C; Gimenez, F; Le Bras, J; Rabenjarson, E; Ringwald, P, 1991) |
| " falciparum cases within seventh day in Purulia and Jalpaiguri districts respectively, with a dosage of 25 mg per kg body weight, spread over three days in divided doses." | 1.28 | Changing response of Plasmodium falciparum to chloroquine in West Bengal during 1980-1988. ( Barkakaty, BN; Narasimham, MV; Pandya, AP, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (1.18) | 18.7374 |
| 1990's | 417 (25.79) | 18.2507 |
| 2000's | 675 (41.74) | 29.6817 |
| 2010's | 393 (24.30) | 24.3611 |
| 2020's | 113 (6.99) | 2.80 |
| Authors | Studies |
|---|---|
| MacKinnon, S | 1 |
| Durst, T | 1 |
| Arnason, JT | 1 |
| Angerhofer, C | 1 |
| Pezzuto, J | 1 |
| Sanchez-Vindas, PE | 1 |
| Poveda, LJ | 1 |
| Gbeassor, M | 1 |
| Avery, MA | 1 |
| Muraleedharan, KM | 1 |
| Desai, PV | 1 |
| Bandyopadhyaya, AK | 1 |
| Furtado, MM | 1 |
| Tekwani, BL | 1 |
| Dong, Y | 3 |
| Chollet, J | 2 |
| Matile, H | 2 |
| Charman, SA | 5 |
| Chiu, FC | 1 |
| Charman, WN | 2 |
| Scorneaux, B | 1 |
| Urwyler, H | 2 |
| Santo Tomas, J | 2 |
| Scheurer, C | 2 |
| Snyder, C | 2 |
| Dorn, A | 2 |
| Wang, X | 6 |
| Karle, JM | 1 |
| Tang, Y | 3 |
| Wittlin, S | 8 |
| Brun, R | 10 |
| Vennerstrom, JL | 4 |
| Gutteridge, CE | 2 |
| Nichols, DA | 1 |
| Curtis, SM | 1 |
| Thota, DS | 1 |
| Vo, JV | 1 |
| Gerena, L | 7 |
| Montip, G | 1 |
| Asher, CO | 1 |
| Diaz, DS | 1 |
| Ditusa, CA | 1 |
| Smith, KS | 1 |
| Bhattacharjee, AK | 2 |
| Skinner-Adams, TS | 3 |
| Andrews, KT | 7 |
| Melville, L | 1 |
| McCarthy, J | 1 |
| Gardiner, DL | 4 |
| Sidhu, AB | 1 |
| Sun, Q | 1 |
| Nkrumah, LJ | 1 |
| Dunne, MW | 4 |
| Sacchettini, JC | 1 |
| Fidock, DA | 19 |
| Noedl, H | 7 |
| Krudsood, S | 4 |
| Leowattana, W | 2 |
| Tangpukdee, N | 2 |
| Thanachartwet, W | 1 |
| Looareesuwan, S | 6 |
| Miller, RS | 3 |
| Fukuda, M | 3 |
| Jongsakul, K | 1 |
| Yingyuen, K | 2 |
| Sriwichai, S | 2 |
| Ohrt, C | 2 |
| Knirsch, C | 1 |
| Baniecki, ML | 1 |
| Wirth, DF | 12 |
| Clardy, J | 2 |
| Ouattara, M | 1 |
| Wein, S | 2 |
| Calas, M | 1 |
| Hoang, YV | 1 |
| Vial, H | 3 |
| Escale, R | 1 |
| Huy, NT | 1 |
| Mizunuma, K | 1 |
| Kaur, K | 1 |
| Nhien, NT | 1 |
| Jain, M | 1 |
| Uyen, DT | 1 |
| Harada, S | 1 |
| Jain, R | 1 |
| Kamei, K | 2 |
| Karunajeewa, HA | 5 |
| Ilett, KF | 6 |
| Mueller, I | 12 |
| Siba, P | 3 |
| Law, I | 4 |
| Page-Sharp, M | 6 |
| Lin, E | 2 |
| Lammey, J | 1 |
| Batty, KT | 2 |
| Davis, TM | 10 |
| Atheaya, H | 2 |
| Khan, SI | 5 |
| Mamgain, R | 1 |
| Rawat, DS | 4 |
| Lisk, G | 1 |
| Pain, M | 1 |
| Gluzman, IY | 1 |
| Kambhampati, S | 1 |
| Furuya, T | 2 |
| Su, XZ | 9 |
| Fay, MP | 1 |
| Goldberg, DE | 1 |
| Desai, SA | 1 |
| Lek-Uthai, U | 1 |
| Suwanarusk, R | 3 |
| Ruengweerayut, R | 1 |
| Nosten, F | 19 |
| Boonma, P | 1 |
| Piera, KA | 2 |
| Machunter, B | 2 |
| McCarthy, JS | 3 |
| Anstey, NM | 7 |
| Price, RN | 9 |
| Russell, B | 3 |
| Dow, GS | 1 |
| Chen, Y | 1 |
| Caridha, D | 2 |
| Gettayacamin, M | 1 |
| Johnson, J | 2 |
| Li, Q | 2 |
| Melendez, V | 1 |
| Obaldia, N | 3 |
| Tran, TN | 1 |
| Kozikowski, AP | 1 |
| Soh, PN | 1 |
| Witkowski, B | 4 |
| Olagnier, D | 1 |
| Nicolau, ML | 1 |
| Garcia-Alvarez, MC | 1 |
| Berry, A | 11 |
| Benoit-Vical, F | 11 |
| Musonda, CC | 1 |
| Whitlock, GA | 1 |
| Witty, MJ | 3 |
| Kaiser, M | 7 |
| Chiang, AN | 1 |
| Valderramos, JC | 2 |
| Balachandran, R | 1 |
| Chovatiya, RJ | 1 |
| Mead, BP | 1 |
| Schneider, C | 1 |
| Bell, SL | 1 |
| Klein, MG | 1 |
| Huryn, DM | 1 |
| Chen, XS | 1 |
| Day, BW | 1 |
| Wipf, P | 1 |
| Brodsky, JL | 1 |
| Kumar, N | 5 |
| Sharma, M | 1 |
| Bacon, DJ | 2 |
| McCollum, AM | 3 |
| Griffing, SM | 2 |
| Salas, C | 2 |
| Soberon, V | 1 |
| Santolalla, M | 1 |
| Haley, R | 1 |
| Tsukayama, P | 1 |
| Lucas, C | 3 |
| Escalante, AA | 3 |
| Udhayakumar, V | 14 |
| Cunico, W | 1 |
| Gomes, CR | 1 |
| Facchinetti, V | 1 |
| Moreth, M | 1 |
| Penido, C | 1 |
| Henriques, MG | 1 |
| Varotti, FP | 1 |
| Krettli, LG | 1 |
| Krettli, AU | 3 |
| da Silva, FS | 1 |
| Caffarena, ER | 1 |
| de Magalhães, CS | 1 |
| Rajalakshmi, G | 1 |
| Kumaradhas, P | 1 |
| Jiménez-Díaz, MB | 6 |
| Mulet, T | 1 |
| Viera, S | 2 |
| Gómez, V | 1 |
| Garuti, H | 1 |
| Ibáñez, J | 3 |
| Alvarez-Doval, A | 1 |
| Shultz, LD | 1 |
| Martínez, A | 1 |
| Gargallo-Viola, D | 1 |
| Angulo-Barturen, I | 6 |
| Omodeo-Salè, F | 1 |
| Cortelezzi, L | 1 |
| Basilico, N | 4 |
| Casagrande, M | 2 |
| Sparatore, A | 3 |
| Taramelli, D | 9 |
| Grimberg, BT | 1 |
| Jaworska, MM | 1 |
| Hough, LB | 1 |
| Zimmerman, PA | 4 |
| Phillips, JG | 1 |
| Iwaniuk, DP | 1 |
| Whetmore, ED | 1 |
| Rosa, N | 1 |
| Ekoue-Kovi, K | 1 |
| Alumasa, J | 1 |
| de Dios, AC | 2 |
| Roepe, PD | 12 |
| Wolf, C | 2 |
| El Hage, S | 1 |
| Ane, M | 1 |
| Stigliani, JL | 1 |
| Marjorie, M | 1 |
| Baziard-Mouysset, G | 1 |
| Payard, M | 1 |
| Mwai, L | 3 |
| Kiara, SM | 3 |
| Abdirahman, A | 2 |
| Pole, L | 1 |
| Rippert, A | 1 |
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| Bull, P | 1 |
| Marsh, K | 2 |
| Borrmann, S | 3 |
| Nzila, A | 5 |
| Guetzoyan, L | 1 |
| Yu, XM | 1 |
| Ramiandrasoa, F | 1 |
| Pethe, S | 1 |
| Rogier, C | 14 |
| Pradines, B | 23 |
| Cresteil, T | 1 |
| Perrée-Fauvet, M | 1 |
| Mahy, JP | 1 |
| Morita, H | 1 |
| Tomizawa, Y | 1 |
| Deguchi, J | 1 |
| Ishikawa, T | 1 |
| Arai, H | 1 |
| Zaima, K | 1 |
| Hosoya, T | 1 |
| Hirasawa, Y | 1 |
| Matsumoto, T | 1 |
| Kamata, K | 1 |
| Ekasari, W | 1 |
| Widyawaruyanti, A | 1 |
| Wahyuni, TS | 1 |
| Zaini, NC | 1 |
| Honda, T | 1 |
| Sriraghavan, K | 1 |
| Creek, DJ | 3 |
| Morizzi, J | 2 |
| Koltun, M | 1 |
| Padmanilayam, M | 1 |
| Nsobya, SL | 9 |
| Kiggundu, M | 2 |
| Nanyunja, S | 1 |
| Joloba, M | 1 |
| Greenhouse, B | 2 |
| Rosenthal, PJ | 28 |
| Salman, S | 3 |
| Baiwog, F | 3 |
| Gomorrai, S | 2 |
| Rogerson, S | 1 |
| Lelièvre, J | 3 |
| Barragán, MJ | 1 |
| Laurent, V | 1 |
| Hans, RH | 1 |
| Gut, J | 6 |
| Chibale, K | 8 |
| Rottmann, M | 2 |
| Chitnumsub, P | 1 |
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| Maneeruttanarungroj, C | 1 |
| Taweechai, S | 1 |
| Yeung, BK | 1 |
| Goh, A | 1 |
| Lakshminarayana, SB | 2 |
| Zou, B | 1 |
| Wong, J | 1 |
| Ma, NL | 1 |
| Weaver, M | 1 |
| Keller, TH | 1 |
| Dartois, V | 1 |
| Yuthavong, Y | 1 |
| Diagana, TT | 2 |
| Ramalhete, C | 1 |
| Lopes, D | 3 |
| Mulhovo, S | 1 |
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| Ferreira, MJ | 1 |
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| Carballeira, NM | 1 |
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| Milhous, WK | 6 |
| Xu, M | 2 |
| Birrell, GW | 2 |
| Tran, TL | 1 |
| Camp, D | 1 |
| Davis, RA | 1 |
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| Patricia Rodriguez, E | 1 |
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| Bolitho, EM | 1 |
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| Murray, PE | 1 |
| Mayence, A | 1 |
| Vanden Eynde, JJ | 1 |
| Yarlett, N | 1 |
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| Francek, C | 1 |
| Chen, Z | 1 |
| Plouffe, D | 1 |
| Lin, X | 1 |
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| Liu, F | 1 |
| Wang, J | 3 |
| Chang, J | 1 |
| Li, C | 2 |
| Liu, B | 1 |
| Hollenbeck, T | 1 |
| Tuntland, T | 1 |
| Isbell, J | 1 |
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| Alper, PB | 1 |
| Fischli, C | 1 |
| Winzeler, EA | 4 |
| Glynne, R | 1 |
| Tully, DC | 1 |
| Chatterjee, AK | 1 |
| Sashidhara, KV | 2 |
| Kumar, A | 7 |
| Dodda, RP | 1 |
| Krishna, NN | 1 |
| Agarwal, P | 4 |
| Srivastava, K | 6 |
| Puri, SK | 4 |
| Avula, SR | 1 |
| Palnati, GR | 1 |
| Singh, SV | 1 |
| Saxena, JK | 1 |
| Barteselli, A | 1 |
| Parapini, S | 4 |
| Pretorius, SI | 1 |
| Breytenbach, WJ | 1 |
| de Kock, C | 1 |
| Smith, PJ | 3 |
| N'Da, DD | 1 |
| Sharma, A | 3 |
| Santos, IO | 1 |
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| da Rocha, DR | 1 |
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| de Dios, A | 1 |
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| Inam, A | 1 |
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| Woster, PM | 1 |
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| Ongarora, DS | 1 |
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| Meister, S | 3 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Malaria Heart Disease Study: A Novel Pathway to Subclinical Heart Disease[NCT04445103] | 597 participants (Actual) | Observational | 2020-06-21 | Terminated (stopped due to Due to the COVID-19 pandemic it was not possible to complete the study inclusion as originally anticipated.) | |||
| A Phase 2a Open Label Study of the Safety and Efficacy of a Single Dose of Weekly Chloroquine (CQ) and Azithromycin (AZ) Administered in Combination for Malaria Prophylaxis in Healthy Adults Challenged With 7G8 Chloroquine-Resistant Plasmodium Falciparum [NCT03278808] | Phase 2 | 0 participants (Actual) | Interventional | 2018-09-17 | Withdrawn (stopped due to The IND has been withdrawn from FDA) | ||
| Comparing Safety and Protective Efficacy of the Whole Plasmodium Falciparum Sporozoite Chemoprophylaxis Vaccine Candidate PfSPZ-CVac and Prime- Target Vaccination With Viral Vectored Vaccine Candidate Regime MVA ME-TRAP/ ChAd63 ME-TRAP in Malaria-naïve, H[NCT05441410] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2024-02-01 | Not yet recruiting | ||
| Evaluating the Potential Role of Chloroquine in Preventing Infections During Elimination Campaigns: A Randomized, Single-blind, Placebo-controlled Trial in Asymptomatic Mozambican Adults[NCT02698748] | Phase 2/Phase 3 | 75 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Effectiveness of Community Level Deployment of Rapid Diagnostic Tests for Malaria in Afghanistan: Cluster Randomised Trial[NCT01403350] | Phase 4 | 2,421 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Host and Parasites Factors Contributing to Risk of Plasmodium Re-infection and Morbidity in Elementary School Children in Maprik, East Sepik Province[NCT02143934] | Phase 4 | 524 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of Glucose-6-dehydrogenase Status in South-east Bangladesh[NCT02389374] | Phase 4 | 181 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual Blood Stag[NCT02511054] | Phase 1 | 57 participants (Actual) | Interventional | 2015-07-21 | Completed | ||
| Experimental Human Malaria Infection After Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis[NCT01236612] | 25 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| Incorporation of the 'Ottawa Malaria Decision Aid' Into the Pre-travel Consultation Process: Assessment of Travelers' Knowledge, Decisional Conflict, Preparation for Decision-making and Medication Adherence Compared to Standard Care[NCT01976325] | 100 participants (Anticipated) | Interventional | 2014-01-31 | Recruiting | |||
| Infections in Migrants in Sweden - the Importance of Malaria and Other Parasitic Infections[NCT05086887] | 715 participants (Anticipated) | Observational [Patient Registry] | 2019-04-15 | Recruiting | |||
| Clinical Efficacy of Artemisinin-based Combination Therapy for Treatment of Uncomplicated Plasmodium Falciparum Malaria in North Sumatera, Indonesia and the Association of Molecular Markers With Treatment Outcomes[NCT02325180] | Phase 4 | 338 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Versus Mefloquine Prophylaxis[NCT01422954] | 20 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau[NCT00137566] | Phase 4 | 0 participants | Interventional | 2004-05-31 | Active, not recruiting | ||
| Chloroquine and Coartem for Treatment of Symptomatic Children With Plasmodium Falciparum in Guinea Bissau.[NCT00426439] | Phase 4 | 300 participants (Anticipated) | Interventional | 2006-12-31 | Completed | ||
| Chloroquine and Amodiaquine for Treatment of Symptomatic Children With Plasmodium Malaria in Guinea-Bissau[NCT00137514] | Phase 4 | 720 participants | Interventional | 2001-03-31 | Completed | ||
| The Routine Use of Coartem for Treatment of Symptomatic Children With Plasmodium Falciparum at the Bandim Health Centre[NCT01157689] | 500 participants (Anticipated) | Observational | 2010-03-31 | Completed | |||
| Efficacy and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for the Treatment of Uncomplicated Malaria in Guinea-Bissau.[NCT01704508] | Phase 4 | 346 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| A Phase II/III, Randomized, Double-Blind, Comparative Trial Of Azithromycin Plus Chloroquine Versus Mefloquine For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In Africa[NCT00082576] | Phase 2/Phase 3 | 238 participants (Actual) | Interventional | 2004-06-30 | Completed | ||
| A Phase 3, Randomized, Open-Label, Comparative Trial Of Azithromycin Plus Chloroquine Versus Mefloquine For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In Africa[NCT00367653] | Phase 3 | 397 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Development of Safer Drugs for Malaria in U.S. Troops, Civilian Personnel, and Travelers: Clinical Evaluation of Primaquine Enantiomer[NCT02898779] | Phase 1 | 36 participants (Actual) | Interventional | 2017-05-01 | Completed | ||
| Phase 2/3, Open-Label, Comparative Trial Of Azithromycin Plus Chloroquine Versus Artemether-Lumefantrine For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In Children In Africa[NCT00677833] | Phase 2/Phase 3 | 361 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Re-exposure of Previously Immunized and Challenged Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites[NCT01660854] | 21 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| Intermittent Preventive Treatment With Azithromycin-containing Regimens for the Prevention of Malarial Infections and Anaemia and the Control of Sexually Transmitted Infections in Pregnant Women in Papua New Guinea[NCT01136850] | Phase 3 | 2,793 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| A Phase I, Randomized Malaria Challenge Study of Intradermally-Administered Infectious (Replication-intact), Cryopreserved Plasmodium Falciparum Sporozoites (PfSPZ Challenge) in Malaria-Naïve Adults[NCT01546389] | Phase 1 | 30 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity[NCT05757167] | Phase 4 | 2,500 participants (Anticipated) | Interventional | 2023-11-06 | Recruiting | ||
| A Phase 3, Open Label, Randomized, Comparative Study To Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa[NCT01103063] | Phase 3 | 2,891 participants (Actual) | Interventional | 2010-10-31 | Terminated (stopped due to See termination reason in detailed description.) | ||
| Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falciparum I[NCT03952650] | Phase 1/Phase 2 | 252 participants (Actual) | Interventional | 2019-05-23 | Completed | ||
| Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis[NCT02115516] | Phase 1 | 67 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| [NCT01075945] | Phase 4 | 140 participants (Anticipated) | Interventional | 2010-02-28 | Recruiting | ||
| Safety, Tolerability and Pharmacokinetics of Tafenoquine After Weekly and Escalating Monthly Doses of Tafenoquine in Healthy Vietnamese Volunteers[NCT05203744] | Phase 4 | 200 participants (Anticipated) | Interventional | 2022-05-10 | Not yet recruiting | ||
| Effect of Single-course Malaria Chemoprevention on Clearance of and Protection From Plasmodium Falciparum Infection in the Presence of Resistance-associated Genotypes in Cameroon[NCT06173206] | Phase 3 | 900 participants (Anticipated) | Interventional | 2024-03-15 | Not yet recruiting | ||
| Exposure of Human Volunteers to Live Malaria Sporozoites Under Chloroquine Prophylaxis[NCT00442377] | 15 participants (Anticipated) | Interventional | 2007-01-31 | Completed | |||
| Safety and Protective Efficacy of Genetically Attenuated Pf∆mei2 (Also Referred to as GA2) Malaria Parasites in Healthy Dutch Volunteers.[NCT04577066] | Phase 1/Phase 2 | 43 participants (Actual) | Interventional | 2021-09-27 | Completed | ||
| Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Dose Escalation Trial to Determine Safety and Development of Protective Efficacy After Exposure to Only Pre-erythrocytic Stages of Plasmodium Falciparum[NCT03083847] | Phase 1 | 55 participants (Actual) | Interventional | 2017-06-05 | Completed | ||
| Identification of Pre-erythrocytic Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis[NCT02080026] | 15 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Chemoprophylaxis and Plasmodium Falciparum NF54 Sporozoite Immunization Challenged by Heterologous Infection[NCT02098590] | 40 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| A Phase Ib Randomised, Controlled, Single-blind Study to Assess the Safety, Immunogenicity of the Malaria Vaccine Candidate R21 With Matrix-M1 Adjuvant in West African Adult Volunteers[NCT02925403] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2016-08-26 | Completed | ||
| Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine or Chloroquine/Azithromycin Prophylaxis[NCT01783340] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2013-04-30 | Withdrawn (stopped due to No funding) | ||
| Re-exposure of EHMI-8 Human Volunteers to Live Malaria Sporozoites[NCT00757887] | 15 participants (Anticipated) | Interventional | 2009-10-31 | Completed | |||
| Pseudo-randomised, Double-blinded Placebo-controlled Trial of Chloroquine or Sulphadoxine-pyrimethamine Alone or in Combination With Primaquine or Artesunate for the Treatment of Uncomplicated Falciparum Malaria in Pakistan[NCT00959517] | Phase 2 | 588 participants (Actual) | Interventional | 2001-07-31 | Completed | ||
| Prospective Assessment of Relapse Characteristics of Plasmodium Ovale and Antimalarial Treatment Efficacy of Artemether-lumefantrine for Mixed Species and Non-falciparum Malaria in Gabon[NCT02528279] | 50 participants (Anticipated) | Interventional | 2014-10-31 | Completed | |||
| Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine (PQ) for the Treatment of Uncomplicated Plasmodium Vivax Infection[NCT02691910] | Phase 2/Phase 3 | 204 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Establishment of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers[NCT01083095] | Early Phase 1 | 18 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Phase 1 and Phase 2a Clinical Trial:Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites[NCT01082341] | Phase 1/Phase 2 | 27 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Evaluation of Reproducibility of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers[NCT00367380] | Phase 2 | 18 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| Evaluation of the Household-level Impact of a Single Round of Intermittent Preventive Treatment of Malaria in Schoolchildren: A Randomized Study[NCT04660110] | Phase 3 | 1,500 participants (Anticipated) | Interventional | 2021-01-28 | Recruiting | ||
| A Phase II, Double Blind, Randomized, Exploratory Study of Chloroquine for Reducing HIV-Associated Immune Activation[NCT00819390] | Phase 2 | 70 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| Characterization of Novel Molecular Tools for the Epidemiological Surveillance of Antimalarial Drug Resistance in Mali[NCT00127998] | 1,011 participants | Interventional | 2005-07-31 | Completed | |||
| A Randomised Double Blind Clinical Trial of Amodiaquine (AQ) and Sulphadoxine-pyrimethamine (SP) Used Singly and in Combination (AQ+SP) Compared With Chloroquine (CQ) in the Treatment of Falciparum Malaria Infection in Pregnancy[NCT00131703] | Phase 3 | 900 participants | Interventional | 2003-03-31 | Completed | ||
| Chloroquine and Sulfadoxine-Pyrimethamine Efficacy for the Treatment of Uncomplicated Falciparum Malaria in Blantyre, Malawi[NCT00125489] | Phase 4 | 210 participants | Interventional | 2005-05-31 | Completed | ||
| A Multi Center Randomized Open Label Trial on the Safety and Efficacy of Chloroquine for the Treatment of Hospitalized Adults With Laboratory Confirmed SARS-CoV-2 Infection in Vietnam[NCT04328493] | Phase 2 | 10 participants (Actual) | Interventional | 2020-04-07 | Completed | ||
| A Randomised Non-Inferiority Trial of Sulfadoxine-Pyrimethamine Plus Artesunate Compared to Chloroquine for the Treatment of Vivax Malaria in Eastern Afghanistan.[NCT00486694] | Phase 2 | 190 participants (Actual) | Interventional | 2004-03-31 | Completed | ||
| Comparison of the Effectiveness of Two Scheme Treatments to Treat Plasmodium Vivax Cases in Patients Living in Communities With Persistence of Transmission in Oaxaca and Chiapas, Mexico[NCT02394197] | Phase 4 | 153 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Short Course of Quinine Plus a Single Dose of Sulphadoxine-Pyrimethamine for Plasmodium Falciparum Malaria[NCT00167739] | Phase 4 | 50 participants | Interventional | 2003-04-30 | Completed | ||
| An Open-label, Phase II, Dose-Escalation Clinical Study to Assess the Pharmacokinetics, Safety, Tolerability and Pharmacodynamics of Fixed Dose Combination of Pyronaridine and Artesunate (3:1) in Children With Acute Falciparum Malaria[NCT00331136] | Phase 2 | 60 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| A Comparative Study of Mefloquine and Sulphadoxine-pyrimethamine as Prophylaxis Against Malaria in Pregnant Human Immunodeficiency Virus Positive Patients[NCT02524444] | Phase 1 | 142 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| A Phase IIIB Comparative Trial of Seasonal Vaccination With the Malaria Vaccine RTS,S/AS01, Seasonal Malaria Chemoprevention and of the Two Interventions Combined[NCT03143218] | Phase 3 | 5,920 participants (Actual) | Interventional | 2017-04-17 | Completed | ||
| Assessment of Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa[NCT02974348] | Phase 3 | 300 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT02389374)
Timeframe: day 16
| Intervention | Participants (Count of Participants) |
|---|---|
| Chloroquine Primaquine 14days | 34 |
| Artemether-lumefantrine Primaquine 1day | NA |
| Artemether-lumefantrine Primaquine 14days | 7 |
(NCT02389374)
Timeframe: day 28
| Intervention | participants (Number) |
|---|---|
| Chloroquine Primaquine 14days | 0 |
| Artemether-lumefantrine Primaquine 1day | 0 |
| Artemether-lumefantrine Primaquine 14days | 0 |
(NCT02389374)
Timeframe: on day 2
| Intervention | participants with Hb under 8g/dl (Number) |
|---|---|
| Chloroquine Primaquine 14days | 0 |
| Artemether-lumefantrine Primaquine 1day | 2 |
| Artemether-lumefantrine Primaquine 14days | 0 |
(NCT02389374)
Timeframe: day 3
| Intervention | participants (Number) |
|---|---|
| Chloroquine Primaquine 14days | 0 |
| Artemether-lumefantrine Primaquine 1day | 2 |
| Artemether-lumefantrine Primaquine 14days | 0 |
(NCT02389374)
Timeframe: day 2
| Intervention | Participants (Count of Participants) |
|---|---|
| Chloroquine Primaquine 14days | 0 |
| Artemether-lumefantrine Primaquine 1day | 0 |
| Artemether-lumefantrine Primaquine 14days | 0 |
(NCT02389374)
Timeframe: day 16
| Intervention | Recurrences of Parsitaemia (Number) |
|---|---|
| Chloroquine Primaquine 14days | 0 |
| Artemether-lumefantrine Primaquine 1day | 0 |
| Artemether-lumefantrine Primaquine 14days | 0 |
(NCT02389374)
Timeframe: day 0
| Intervention | U/gHb (Median) |
|---|---|
| All Malaria Patients | 7.82 |
The proportion of adverse and serious adverse events following unsupervised primaquine treatment until day 28 (NCT02389374)
Timeframe: during follow up (day 28)
| Intervention | events (Number) |
|---|---|
| Chloroquine Primaquine 14days | 0 |
| Artemether-lumefantrine Primaquine 1day | 0 |
| Artemether-lumefantrine Primaquine 14days | 0 |
(NCT02389374)
Timeframe: day 0 and 16
| Intervention | percent change Hb (Mean) | |
|---|---|---|
| baseline to day 9 | baseline to day 16 | |
| Artemether-lumefantrine Primaquine 14days | -13.8 | -8.3 |
| Artemether-lumefantrine Primaquine 1day | -7.7 | NA |
| Chloroquine Primaquine 14days | -2.3 | -0.5 |
Defined as time to first of two consecutive zero asexual P. falciparum parasite (PCR-corrected) counts, regardless of recurrence of parasitemia later. PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation. (NCT00677833)
Timeframe: Baseline to Day 42
| Intervention | Hours (Median) |
|---|---|
| Cohort 2: Azithromycin + Chloroquine | 48.000 |
| Cohort 2: Artemether + Lumefantrine | 24.000 |
Calculated as time of first occurrence of two consecutive time points with temperature less than (<) 38.0 degrees C/100.4 degrees Fahrenheit (F) (rectal), 37.2 degrees C/99.0 degrees F (axillary), or <37.5 degrees C/99.5 degrees F (oral). (NCT00677833)
Timeframe: Baseline to Day 42
| Intervention | Hours (Median) |
|---|---|
| Cohort 2: Azithromycin + Chloroquine | 24.000 |
| Cohort 2: Artemether + Lumefantrine | 24.000 |
Nadir hemoglobin for each participant was defined as the minimum hemoglobin values obtained from Day 0 through Day 3. (NCT00677833)
Timeframe: Day 0 through Day 3
| Intervention | grams per deciliter (g/dL) (Mean) |
|---|---|
| Cohort 2: Azithromycin + Chloroquine | 9.63 |
| Cohort 2: Artemether + Lumefantrine | 9.82 |
"ETF defined as participants who met the following criteria:~Developed signs of severe malaria or clinical deterioration that required rescue medication on Days 0, 1, 2 or 3, in the presence of P. falciparum parasitemia~Last available asexual P. falciparum parasite count on Day 2 greater than the first available parasite count on Day 0 (Baseline), irrespective of axillary, oral or rectal temperature.~Parasitemia (P. falciparum) on Day 3 with fever or~Last available P. falciparum parasite count on Day 3 >=25% of the first available parasite count on Day 0 (Baseline).~PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation." (NCT00677833)
Timeframe: Day 0 up to Day 3
| Intervention | Percentage of participants (Number) |
|---|---|
| Cohort 2: Azithromycin + Chloroquine | 5.83 |
| Cohort 2: Artemether + Lumefantrine | 0.79 |
"ETF defined as participants who met the following criteria:~Developed signs of severe malaria or clinical deterioration that required rescue medication on Days 0, 1, 2 or 3, in the presence of P.falciparum parasitemia~Last available asexual P.falciparum parasite count on Day 2 greater than the first available parasite count on Day 0 (Baseline), irrespective of axillary, oral or rectal temperature.~Parasitemia (P.falciparum) on Day 3 with fever or~Last available P.falciparum parasite count on Day 3 >=25% of the first available parasite count on Day 0 (Baseline).~PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation." (NCT00677833)
Timeframe: Day 0 up to Day 3
| Intervention | Percentage of participants (Number) |
|---|---|
| Cohort 2: Azithromycin + Chloroquine | 1.75 |
| Cohort 2: Artemether + Lumefantrine | 0 |
ACPR (PCR-corrected) was defined as asexual P.falciparum parasitologic clearance at Day 28 irrespective of axillary, oral, rectal, or tympanic temperature, without previously meeting the criteria of ETF (see measure description in secondary outcome measures 7 and 8) or PCR-corrected LTF (which includes PCR-corrected LCF - see measure description in secondary outcome measure 9 and 10, and PCR-corrected LPF - see measure description in secondary outcome measure 11 and 12). PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation. (NCT00677833)
Timeframe: Day 28
| Intervention | Percentage of participants (Number) |
|---|---|
| Cohort 2: Azithromycin + Chloroquine | 93.08 |
| Cohort 2: Artemether + Lumefantrine | 99.16 |
ACPR (PCR-corrected) was defined as asexual Plasmodium falciparum (P.falciparum) parasitologic clearance at Day 28 irrespective of axillary, oral, rectal, or tympanic temperature, without previously meeting the criteria of Early Treatment Failure (ETF) (see measure description in secondary outcome measures 7 and 8) or PCR-corrected Late Treatment Failure (LTF) (which includes PCR-corrected Late Clinical Failures [LCF] - see measure description in secondary outcome measure 9 and 10, and PCR-corrected Late Parasitologic Failures (LPF)- see measure description in secondary outcome measure 11 and 12). PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation. (NCT00677833)
Timeframe: Day 28
| Intervention | Percentage of participants (Number) |
|---|---|
| Cohort 2: Azithromycin + Chloroquine | 89.27 |
| Cohort 2: Artemether + Lumefantrine | 98.37 |
Time from the day of clearance to the time of recurrence of asexual P.falciparum parasitemia (PCR-uncorrected). (NCT00677833)
Timeframe: Baseline (Day 0) to Day 42
| Intervention | Days (Median) |
|---|---|
| Cohort 2: Azithromycin + Chloroquine | 34 |
| Cohort 2: Artemether + Lumefantrine | NA |
Change from nadir = observation minus nadir. Nadir defined as the minimum value for each participant on Days 0-3. (NCT00677833)
Timeframe: Day 14, 28, 42
| Intervention | g/dL (Mean) | ||
|---|---|---|---|
| Change at Day 14 (n=122, 127) | Change at Day 28 (n=122, 127) | Change at Day 42 (n=122, 128) | |
| Cohort 2: Artemether + Lumefantrine | 0.44 | 0.96 | 1.14 |
| Cohort 2: Azithromycin + Chloroquine | 0.52 | 1.15 | 1.29 |
Percentage of participants who were cleared of asexual parasites. Asexual parasite clearance - clearance of asexual P.falciparum parasitemia within 7 days of initiation of treatment without subsequent recurrence (PCR-corrected) through the day of consideration. PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation. (NCT00677833)
Timeframe: Day 7, 14, 21, 28, 35, 42
| Intervention | Percentage of participants (Number) | |||||
|---|---|---|---|---|---|---|
| Day 7 (n=120, 128) | Day 14 (n=120, 127) | Day 21 (n=120, 128) | Day 28 (n=120, 127) | Day 35 (n=120, 128) | Day 42 (n=120, 127) | |
| Cohort 2: Artemether + Lumefantrine | 99.22 | 99.21 | 98.44 | 98.43 | 96.88 | 96.85 |
| Cohort 2: Azithromycin + Chloroquine | 93.33 | 91.67 | 90.83 | 89.17 | 89.17 | 88.33 |
Gametocyte response/absence/clearance: Clearance of P.falciparum gametocytemia (PCR-uncorrected) (attainment of 2 consecutive zero gametocyte counts) without subsequent recurrence through the day of consideration. PCR-uncorrected: not adjusted for molecular testing which determined recrudescence or true failures from reinfection. (NCT00677833)
Timeframe: Days 7, 14, 21, 28, 35, 42
| Intervention | Percentage of participants (Number) | |||||
|---|---|---|---|---|---|---|
| Day 7 (n=122, 129) | Day 14 (n=122, 130) | Day 21 (n=122, 130) | Day 28 (n=122, 130) | Day 35 (n=122, 130) | Day 42 (n=122, 130) | |
| Cohort 2: Artemether + Lumefantrine | 91.47 | 91.54 | 93.08 | 93.08 | 92.31 | 91.54 |
| Cohort 2: Azithromycin + Chloroquine | 81.97 | 81.15 | 80.33 | 81.97 | 81.97 | 80.33 |
"LCF included participants who met any of the following criteria:~Development of signs of severe malaria or clinical deterioration requiring rescue medication after Day 3 in the presence of P.falciparum parasitemia, without previously meeting any of the criteria of ETF (see measure description in secondary outcome measures 7 and 8)~Presence of P.falciparum parasitemia and fever on any day from Day 4 onward, without previously meeting any of the criteria of ETF (see measure description in secondary outcome measures 7 and 8). PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation." (NCT00677833)
Timeframe: Days 7, 14, 21, 28, 35, 42
| Intervention | Percentage of participants (Number) | |||||
|---|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 21 | Day 28 | Day 35 | Day 42 | |
| Cohort 2: Artemether + Lumefantrine | 0 | 0 | 0 | 0 | 0 | 0 |
| Cohort 2: Azithromycin + Chloroquine | 0 | 0 | 0 | 0 | 0 | 0 |
LPF: Presence of P. falciparum parasitemia in the mITT population on any day from Day 7 onward and the absence of fever without previously meeting any of the criteria of ETF (see measure description in secondary outcome measures 7 and 8) or LCF (see measure description in secondary outcome measure 9 and 10). PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation. (NCT00677833)
Timeframe: Days 7, 14, 21, 28, 35, 42
| Intervention | Percentage of participants (Number) | |||||
|---|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 21 | Day 28 | Day 35 | Day 42 | |
| Cohort 2: Artemether + Lumefantrine | 0 | 0 | 0.79 | 0.79 | 2.38 | 2.38 |
| Cohort 2: Azithromycin + Chloroquine | 0 | 1.67 | 2.50 | 4.17 | 4.17 | 5.00 |
"LCF included participants who met any of the following criteria:~Development of signs of severe malaria or clinical deterioration requiring rescue medication after Day 3 in the presence of P.falciparum parasitemia, without previously meeting any of the criteria of ETF (see measure description in secondary outcome measures 7 and 8)~Presence of P.falciparum parasitemia and fever on any day from Day 4 onward, without previously meeting any of the criteria of ETF (see measure description in secondary outcome measures 7 and 8). PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation." (NCT00677833)
Timeframe: Days 7, 14, 21, 28, 35, 42
| Intervention | Percentage of participants (Number) | |||||
|---|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 21 | Day 28 | Day 35 | Day 42 | |
| Cohort 2: Artemether + Lumefantrine | 0 | 0 | 0 | 0 | 0 | 0 |
| Cohort 2: Azithromycin + Chloroquine | 0 | 0 | 0 | 0 | 0 | 0 |
LPF: Presence of P.falciparum parasitemia in the PP population on any day from Day 7 onward and the absence of fever without previously meeting any of the criteria of ETF (see measure description in secondary outcome measures 7 and 8) or LCF (see measure description in secondary outcome measure 9 and 10). PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation. (NCT00677833)
Timeframe: Days 7, 14, 21, 28, 35, 42
| Intervention | Percentage of participants (Number) | |||||
|---|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 21 | Day 28 | Day 35 | Day 42 | |
| Cohort 2: Artemether + Lumefantrine | 0 | 0 | 0.81 | 0.81 | 2.42 | 2.42 |
| Cohort 2: Azithromycin + Chloroquine | 0 | 1.75 | 2.63 | 4.39 | 4.39 | 5.26 |
ACPR (PCR-corrected) was defined as asexual P.falciparum parasitologic clearance on Days 7, 14, 21, 35, 42 irrespective of axillary, oral, rectal, or tympanic temperature, without previously meeting the criteria of ETF (see measure description in secondary outcome measures 7 and 8) or PCR-corrected LTF (which includes PCR-corrected LCF - see measure description in secondary outcome measure 9 and 10, and PCR-corrected LPF - see measure description in secondary outcome measure 11 and 12). PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation. (NCT00677833)
Timeframe: Days 7, 14, 21, 35, 42
| Intervention | Percentage of participants (Number) | ||||
|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 21 | Day 35 | Day 42 | |
| Cohort 2: Artemether + Lumefantrine | 100.00 | 100.00 | 99.16 | 96.96 | 96.96 |
| Cohort 2: Azithromycin + Chloroquine | 98.25 | 96.46 | 95.53 | 93.08 | 91.29 |
ACPR (PCR-corrected) was defined as asexual P.falciparum parasitologic clearance on Days 7, 14, 21, 35, 42 irrespective of axillary, oral, rectal, or tympanic temperature, without previously meeting the criteria of ETF (see measure description in secondary outcome measures 7 and 8) or PCR-corrected LTF (which includes PCR-Corrected LCF- see measure description in secondary outcome measure 9 and 10, and PCR-corrected LPF - see measure description in secondary outcome measure 11 and 12). PCR-corrected refers to the use of molecular testing to differentiate recrudescence from reinfection in the context of an efficacy evaluation. (NCT00677833)
Timeframe: Days 7, 14, 21, 35, 42
| Intervention | Percentage of participants (Number) | ||||
|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 21 | Day 35 | Day 42 | |
| Cohort 2: Artemether + Lumefantrine | 99.21 | 99.21 | 98.37 | 96.19 | 96.19 |
| Cohort 2: Azithromycin + Chloroquine | 94.17 | 92.47 | 91.59 | 89.27 | 87.55 |
ACPR (PCR-uncorrected) was defined as asexual P.falciparum parasitologic clearance on Days 7, 14, 21, 28, 35, 42 irrespective of axillary, oral, rectal, or tympanic temperature, without previously meeting the criteria of ETF (see measure description in secondary outcome measures 7 and 8) or PCR-uncorrected LTF (which includes PCR-uncorrected LCF - see measure description in secondary outcome measure 9 and 10, and PCR-uncorrected LPF - see measure description in secondary outcome measure 11 and 12). PCR-uncorrected: not adjusted for molecular testing which determined recrudescence or true failures from reinfection. (NCT00677833)
Timeframe: Days 7, 14, 21, 28, 35, 42
| Intervention | Percentage of participants (Number) | |||||
|---|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 21 | Day 28 | Day 35 | Day 42 | |
| Cohort 2: Artemether + Lumefantrine | 100.00 | 97.56 | 83.62 | 73.90 | 63.41 | 56.74 |
| Cohort 2: Azithromycin + Chloroquine | 98.25 | 92.89 | 70.56 | 54.28 | 47.04 | 39.80 |
ACPR (PCR-uncorrected) was defined as asexual P.falciparum parasitologic clearance on Days 7, 14, 21, 28, 35, 42 irrespective of axillary, oral, rectal, or tympanic temperature, without previously meeting the criteria of ETF (see measure description in secondary outcome measures 7 and 8) or PCR-uncorrected LTF (which includes PCR-uncorrected LCF - see measure description in secondary outcome measure 9 and 10, and PCR-uncorrected LPF - see measure description in secondary outcome measure 11 and 12). PCR-uncorrected: not adjusted for molecular testing which determined recrudescence or true failures from reinfection. (NCT00677833)
Timeframe: Days 7, 14, 21, 28, 35, 42
| Intervention | Percentage of participants (Number) | |||||
|---|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 21 | Day 28 | Day 35 | Day 42 | |
| Cohort 2: Artemether + Lumefantrine | 99.21 | 96.79 | 82.96 | 73.31 | 62.91 | 56.29 |
| Cohort 2: Azithromycin + Chloroquine | 94.17 | 89.08 | 67.87 | 51.55 | 44.67 | 37.80 |
Birth weight of live borne neonates were calculated in grams. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age.
| Intervention | grams (Least Squares Mean) |
|---|---|
| Azithromycin + Chloroquine | 3148.3 |
| Sulfadoxine + Pyrimethamine | 3146.2 |
Change from Baseline to 36-38 weeks of gestation in Hb concentration was noted. (NCT01103063)
Timeframe: Baseline, at 36-38 weeks of gestation.
| Intervention | g/dL (Least Squares Mean) |
|---|---|
| Azithromycin + Chloroquine | 0.13 |
| Sulfadoxine + Pyrimethamine | 0.27 |
This outcome measure determined if an episode of malaria started within the time period of first dose to delivery. Clinical episode of malaria was determined if the participant presented with clinical symptoms of malaria (fever >37.5°C, oral) and diagnosed (either by rapid diagnostic tests or microscopy) with malaria. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Number of episodes (Least Squares Mean) |
|---|---|
| Azithromycin + Chloroquine | 0.06 |
| Sulfadoxine + Pyrimethamine | 0.13 |
Neonates with congenital abnormalities at birth were noted. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age.
| Intervention | Percentage of neonates (Number) |
|---|---|
| Azithromycin + Chloroquine | 2.19 |
| Sulfadoxine + Pyrimethamine | 2.44 |
LBW was defined as live birth weight <2500 g (up to and including 2499 g). (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of neonates (Number) |
|---|---|
| Azithromycin + Chloroquine | 4.72 |
| Sulfadoxine + Pyrimethamine | 5.21 |
LBW was defined as live birth weight <2500 g (up to and including 2499 g). (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of neonates (Number) |
|---|---|
| Azithromycin + Chloroquine | 5.01 |
| Sulfadoxine + Pyrimethamine | 5.72 |
Ophthalmia neonatorum was diagnosed at birth. The laboratory diagnosis was performed among neonates with purulent discharge. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of neonates (Number) |
|---|---|
| Azithromycin + Chloroquine | 0.35 |
| Sulfadoxine + Pyrimethamine | 0.17 |
This outcome measure evaluated the participants requiring additional treatments for malaria during the study period following the first dose (diagnosed based on clinical presentation and/or lab test results). (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 5.74 |
| Sulfadoxine + Pyrimethamine | 10.52 |
Participants positive for bacterial infections including other lower respiratory tract infections were measured anytime from first dose administration to delivery. (NCT01103063)
Timeframe: Up to approximately 40 weeks of gestational age
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 0.48 |
| Sulfadoxine + Pyrimethamine | 1.25 |
Bacterial vaginosis was diagnosed based on laboratory result at 36-38 weeks of gestation. A vaginal swab was collected for the Gram staining. (NCT01103063)
Timeframe: At 36-38 weeks of gestation
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 8.58 |
| Sulfadoxine + Pyrimethamine | 11.84 |
Participants positive for Chlamydia trachomatis infection was diagnosed based on laboratory result at 36-38 weeks of gestation. A vaginal swab was collected and PCR assay was used for analysis. (NCT01103063)
Timeframe: At 36-38 weeks of gestation
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 1.47 |
| Sulfadoxine + Pyrimethamine | 0.63 |
This outcome measure evaluated the percentage of participants positive for cord blood parasitemia at delivery. A participant was positive for parasitemia if the number of asexual parasites per μL was >0. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 0.49 |
| Sulfadoxine + Pyrimethamine | 0.75 |
Anemia was defined as Hb <11 g/dL. (NCT01103063)
Timeframe: At 36-38 weeks of gestation.
| Intervention | Percentage of Participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 50.57 |
| Sulfadoxine + Pyrimethamine | 49.11 |
Participants positive for Neisseria gonorrhoeae infection was diagnosed based on laboratory result at 36-38 weeks of gestation. A vaginal swab was collected and PCR assay was used for analysis. (NCT01103063)
Timeframe: At 36-38 weeks of gestation
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 0.40 |
| Sulfadoxine + Pyrimethamine | 1.64 |
This outcome measure evaluated the percentage of participants positive for peripheral parasitemia at 36-38 weeks of gestation. A participant was positive for parasitemia if the number of asexual parasites per μL was >0. (NCT01103063)
Timeframe: At 36-38 weeks of gestation
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 2.71 |
| Sulfadoxine + Pyrimethamine | 4.38 |
This outcome measure evaluated the percentage of participants positive for peripheral parasitemia at delivery. A participant was positive for parasitemia if the number of asexual parasites per μL was >0. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 6.05 |
| Sulfadoxine + Pyrimethamine | 7.46 |
Participants positive for placental malaria at delivery were evaluated based on placental histology. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 4.81 |
| Sulfadoxine + Pyrimethamine | 5.73 |
Participants with placental parasitemia at delivery were diagnosed using Placental blood smear at birth from participants who deliver at hospital. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 5.30 |
| Sulfadoxine + Pyrimethamine | 5.67 |
Pre-eclampsia was diagnosed as systolic blood pressure of at least 140 mmHg and/or diastolic blood pressure of at least 90 mmHg on two separate readings taken at least 4 hours apart and proteinuria at least 300 mg protein in a 24 hour urine collection. (NCT01103063)
Timeframe: From Week 20 to approximately 40 weeks of gestational age
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 0.63 |
| Sulfadoxine + Pyrimethamine | 1.04 |
Severe maternal anemia was defined as Hb <8 g/dL. (NCT01103063)
Timeframe: At 36-38 weeks of gestation.
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 1.80 |
| Sulfadoxine + Pyrimethamine | 2.00 |
Sexual transmitted disease included Treponema pallidum, Neisseria gonorrhoeae, and Chlamydia trachomatis infections. This was diagnosed based on clinical presentation prior to Week 36-38 and/or lab test results between Week 36-38. (NCT01103063)
Timeframe: Upto 36-38 weeks of gestation
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 12.32 |
| Sulfadoxine + Pyrimethamine | 16.47 |
Adverse pregnancy outcomes were defined as live-borne neonate (singleton) with LBW (<2,500g), premature births (<37 weeks as confirmed by the Ballard score), abortion (≤28 weeks), still birth (>28 weeks), lost to follow-up prior to termination of pregnancy or delivery, or missing birth weight of the neonates. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of Participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 10.38 |
| Sulfadoxine + Pyrimethamine | 10.12 |
Sub-optimal pregnancy outcome including neonatal deaths and congenital malformations, defined as any of the following: live-borne neonate (singleton) with low birth-weight (or LBW for short, defined as live birth weight <2,500g), premature birth (<37 weeks), abortion (≤28 weeks), still birth (>28 weeks), neonatal death, congenital malformation, lost to follow-up prior to termination of pregnancy or delivery, or missing birth weight of the neonates. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age.
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 28.51 |
| Sulfadoxine + Pyrimethamine | 26.51 |
Participants positive for Treponema pallidum infection was diagnosed based on laboratory result at 36-38 weeks of gestation. Treponema Pallidum particle Agglutination Assay was used. (NCT01103063)
Timeframe: At 36-38 weeks of gestation
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 0.93 |
| Sulfadoxine + Pyrimethamine | 2.01 |
Participants positive for Trichomonas vaginalis infection was diagnosed based on laboratory result at 36-38 weeks of gestation. A vaginal swab was collected for the laboratory test. (NCT01103063)
Timeframe: At 36-38 weeks of gestation
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 8.24 |
| Sulfadoxine + Pyrimethamine | 10.67 |
Percentage of perinatal or neonatal deaths were noted. (NCT01103063)
Timeframe: Day 28 after delivery.
| Intervention | Percentage of neonates (Number) |
|---|---|
| Azithromycin + Chloroquine | 2.19 |
| Sulfadoxine + Pyrimethamine | 1.85 |
Adverse pregnancy outcomes were defined as live-borne neonate (singleton) with low birth weight (LBW) (<2,500 g), premature births (<37 weeks as confirmed by the Ballard score), abortion (≤28 weeks), still birth (>28 weeks), lost to follow-up prior to termination of pregnancy or delivery, or missing birth weight of the neonates. (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age
| Intervention | Percentage of participants (Number) |
|---|---|
| Azithromycin + Chloroquine | 26.16 |
| Sulfadoxine + Pyrimethamine | 23.67 |
Number of episodes of sexually transmitted infection episodes per participant were noted. The STI's including Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis, from first dose to delivery (diagnosis was based on clinical presentation and lab results). (NCT01103063)
Timeframe: Approximately 40 weeks of gestational age .
| Intervention | Number of episodes (Least Squares Mean) |
|---|---|
| Azithromycin + Chloroquine | 0.14 |
| Sulfadoxine + Pyrimethamine | 0.19 |
This outcome measure evaluated the Streptococcus pneumoniae sensitivity against macrolide antibiotics. (NCT01103063)
Timeframe: Visits 6 and 7
| Intervention | Percentage of participants (Number) | |
|---|---|---|
| Visit 6 (N = 8 and 17 respectively) | Visit 7 (N = 16 and 11 respectively) | |
| Azithromycin + Chloroquine | 0 | 0 |
| Sulfadoxine + Pyrimethamine | 11.76 | 0 |
This outcome measure evaluated the Streptococcus pneumoniae sensitivity against penicillin antibiotics. (NCT01103063)
Timeframe: Visits 6 and 7
| Intervention | Percentage of participants (Number) | |
|---|---|---|
| Visit 6 (N = 8 and 17 respectively) | Visit 7 (N = 16 and 11 respectively) | |
| Azithromycin + Chloroquine | 0 | 0 |
| Sulfadoxine + Pyrimethamine | 0 | 0 |
Count of participants with local and systemic adverse events (AEs) and serious adverse events (SAEs) occurring after PfSPZ-CVac immunization. This outcome measure applies to main phase arms 1b, 2b, 4a, and 4b. Arms 5b and 6b were not performed as patent parasitemia with the higher dose of PfSPZ was not observed in the pilot phase (Arms 1a, 2a). (NCT03952650)
Timeframe: For the main phase: from the day of inoculation to approximately 6 months post-3rd inoculation. For the booster phase: from the time of inoculation to approximately 6 months post-booster inoculation
| Intervention | Participants (Count of Participants) |
|---|---|
| 1b - Safety/Efficacy: Dosing Interval on Days: 1, 29, 57 | 88 |
| 2b - Safety/Efficacy: Dosing Interval on Days: 1, 29, 57 | 59 |
| 4a - Safety Comparator: Dosing Interval on Days: 1, 29, 57 | 51 |
| 4b - Safety Comparator: Dosing Interval on Days: 1, 29, 57 | 36 |
Count of participants with local and systemic grade 3 signs or symptoms lasting more than 48 hours despite adequate management and serious adverse events (SAEs) occurring after PfSPZ-CVac DVI. Only arm 3a was analyzed for this outcome measure, per the protocol objectives. (NCT03952650)
Timeframe: From day of inoculation to 14 days post-inoculation
| Intervention | Participants (Count of Participants) |
|---|---|
| 3a - Pilot/Safety: Dosing Interval on Days: 1 | 0 |
Count of participants with positive sensitive blood smear (sBS) occurring after PfSPZ-CVac immunization starting on day 7 post DVI. Only pilot phase arms (Arms 1a, 2a) were analyzed for this outcome measure. Arms 5a and 6a were not performed, as no patent parasitemia was observed in either Arms 1a or 2a, per the protocol. (NCT03952650)
Timeframe: 7 -12 days post-inoculation
| Intervention | Participants (Count of Participants) |
|---|---|
| 1a - Pilot/Safety: Dosing Interval on Days: 1 | 0 |
| 2a - Pilot/Safety: Dosing Interval on Days: 1 | 0 |
Incidence of a clinical malaria diagnosis occurring after PfSPZ-Cvac challenge requiring treatment with atovaquone/proguanil (Malarone). (NCT03083847)
Timeframe: 12 days post PfSPZ Challenge injection
| Intervention | participants (Number) |
|---|---|
| Main (3): 3 Doses of 2x10^5 PfSPZ + Chloroquine + 7G8 CHMI | 0 |
| Pilot (5a): 1 Injection of 1x10^5 PfSPZ Challenge+Chloroquine | 0 |
| Pilot (5b): 1 Dose of 2x10^5 PfSPZ Challenge + Chloroquine | 0 |
Participants who had one or more episodes of related or/and unrelated adverse events (AEs). An AE is defined as any untoward medical occurrence temporarily associated with the subject's participation in research, whether or not considered related or not. Refer to adverse event table for specific AE. (NCT03083847)
Timeframe: 7 months
| Intervention | participants (Number) |
|---|---|
| Pilot (1a):1 Injection of 5x10^4 PfSPZ Challenge+Pyrimethamine | 2 |
| Pilot (1b):1 Injection of 1x10^5 PfSPZ Challenge+Pyrimethamine | 2 |
| Pilot (1d):1 Injection of 2x10^5 PfSPZ Challenge+Pyrimethamine | 3 |
| Main (2a):3 Doses of 2x10^5 PfSPZ Challenge+Pyrimethamine+NF54 | 8 |
| Main (2b):3 Doses of 2x10^5 PfSPZ Challenge+Pyrimethamine+7G8 | 9 |
| Main (3):3 Doses of 2x10^5 PfSPZ Challenge+Chloroquine+7G8 | 10 |
| Pilot (5a): 1 Injection of 1x10^5 PfSPZ Challenge+Chloroquine | 2 |
| Pilot (5b): 1 Injection of 2x10^5 PfSPZ Challenge+Chloroquine | 4 |
Participants with P. falciparum blood stage infection defined as detection of P. falciparum parasites by qPCR (real time NIH qPCR and sensitive retrospective Laboratory of Malaria Immunology & Vaccinology (LMIV) qPCR) following Sanaria® PfSPZ Challenge (NF54) via direct venous injection (DVI). (NCT03083847)
Timeframe: 14 days post PfSPZ Challenge injection
| Intervention | Participants (Number) |
|---|---|
| Pilot (1a):1 Injection of 5x10^4 PfSPZ Challenge+Pyrimethamine | 0 |
| Pilot (1b): 1 Dose of 1x10^5 PfSPZ Challenge + Pyrimethamine | 0 |
| Pilot (1d): 1 Dose of 2x10^5 PfSPZ Challenge + Pyrimethamine | 0 |
| Main (2a): 3 Doses of 2x10^5 PfSPZ + Pyrimethamine + NF54 CHMI | 0 |
| Main (2b): 3 Doses of 2x10^5 PfSPZ + Pyrimethamine + 7G8 CHMI | 0 |
Participants who had one or more episodes of serious adverse events (SAEs). SAE is defined as a life-threatening reaction or event that results in death. (NCT03083847)
Timeframe: 7 months
| Intervention | participants (Number) |
|---|---|
| Pilot (1a):1 Injection of 5x10^4 PfSPZ Challenge+Pyrimethamine | 0 |
| Pilot (1b):1 Injection of 1x10^5 PfSPZ Challenge+Pyrimethamine | 0 |
| Pilot (1d):1 Injection of 2x10^5 PfSPZ Challenge+Pyrimethamine | 0 |
| Main (2a):3 Doses of 2x10^5 PfSPZ Challenge+Pyrimethamine+NF54 | 0 |
| Main (2b):3 Doses of 2x10^5 PfSPZ Challenge+Pyrimethamine+7G8 | 0 |
| Main (3):3 Doses of 2x10^5 PfSPZ Challenge+Chloroquine+7G8 | 2 |
| Pilot (5a): 1 Injection of 1x10^5 PfSPZ Challenge+Chloroquine | 0 |
| Pilot (5b): 1 Injection of 2x10^5 PfSPZ Challenge+Chloroquine | 0 |
Occurrence of solicited local and systemic adverse events (i.e: pain, redness, swelling and pruritus at injection site and temperature, feverishness, myalgia, arthralgia, malaise, headache and nausea). (NCT02925403)
Timeframe: Assessment of solicited AEs in the first 7 days post vaccination.
| Intervention | Number of adverse events (Number) |
|---|---|
| Group 1 | 10 |
| Group 2 | 0 |
Occurrence of laboratory adverse events defined as clinically significant changes from baseline. Haematology (Full Blood Count) and Biochemistry (Kidney and Liver Function Tests) will be assessed. (NCT02925403)
Timeframe: At Day 0 (baseline), day 7 and day 28 post vaccination.
| Intervention | Laboratory AEs (Number) |
|---|---|
| Group 1 | 18 |
| Group 2 | 15 |
Occurrence of serious adverse events will be collected from enrolment until the end of the follow-up period. (NCT02925403)
Timeframe: 6 months
| Intervention | SAEs (Number) |
|---|---|
| Group 1 | 0 |
| Group 2 | 0 |
Occurrence of unsolicited local and systemic adverse events. This will be done by recording the number of participants who experience unsolicited adverse events. (NCT02925403)
Timeframe: Unsolicited AEs to be assessed up to 28 days post vaccination.
| Intervention | participants (Number) |
|---|---|
| Group 1 | 8 |
| Group 2 | 5 |
Thick blood smear was performed to patients daily on days 7 to 23, and every other day until day 29. Any prove of P. vivax infection was considered positive and confirmed later by real time polymerase chain reaction (rPCR). (NCT00367380)
Timeframe: Twenty eight days
| Intervention | days (Mean) |
|---|---|
| Group 1 | 11 |
| Group 2 | 11 |
| Group 3 | 9 |
The baseline percent CD8 HLA-DR+/CD38+ (mean of pre-entry and entry percent CD8 HLA-DR+/CD38+) was subtracted from the mean of week 10 and week 12 percent CD8 HLA-DR+/CD38+. (NCT00819390)
Timeframe: At pre-entry, entry, weeks 10 and 12
| Intervention | percent of CD8 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | -2.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | -0.5 |
| C: Chloroquine Then Placebo for On-ART Participants | -3.1 |
| D: Placebo Then Chloroquine for On-ART Participants | -1.2 |
The baseline percent CD8 HLA-DR+/CD38+ (mean of pre-entry and entry percent CD8 HLA-DR+/CD38+) was subtracted from the mean of week 22 and week 24 percent CD8 HLA-DR+/CD38+. (NCT00819390)
Timeframe: At Pre-entry, entry, Weeks 22 and 24
| Intervention | percent of CD8 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 10.8 |
| C: Chloroquine Then Placebo for On-ART Participants | -2.4 |
For Arm A: Chloroquine then Placebo for off-ART participants and Arm C: Chloroquine then Placebo for on-ART participants, the baseline percent CD8 HLA-DR+/CD38+ (mean of pre-entry and entry percent CD8 HLA-DR+/CD38+) was subtracted from the mean of week 10 and week 12 percent CD8 HLA-DR+/CD38+. For Arm B: Placebo then Chloroquine for off-ART participants and Arm D: Placebo then Chloroquine for on-ART participants, the mean of week 10 and week 12 percent CD8 HLA-DR+/CD38+ was subtracted from the mean of week 22 and week 24 percent CD8 HLA-DR+/CD38+. (NCT00819390)
Timeframe: For Arms A and C: Pre-entry, entry, weeks 10 and 12. For Arms B and D: Weeks 10, 12, 22 and 24
| Intervention | percent of CD8 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | -2.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.5 |
| C: Chloroquine Then Placebo for On-ART Participants | -3.1 |
| D: Placebo Then Chloroquine for On-ART Participants | -2.9 |
The mean of week 10 and week 12 percent CD8 HLA-DR+/CD38+ is subtracted from the mean of the week 22 and week 24 percent CD8 HLA-DR+/CD38+ (NCT00819390)
Timeframe: At Weeks 10, 12, 22 and 24
| Intervention | percent of CD8 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 5.5 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.5 |
| C: Chloroquine Then Placebo for On-ART Participants | -0.1 |
| D: Placebo Then Chloroquine for On-ART Participants | -2.9 |
Baseline CD4 count (mean of pre-entry and entry CD4 count) is subtracted from the mean of week 10 and week 12 CD4 count (NCT00819390)
Timeframe: At pre-entry, entry, weeks 10 and 12
| Intervention | cells/mm^3 (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | -27 |
| B: Placebo Then Chloroquine for Off-ART Participants | -11 |
| C: Chloroquine Then Placebo for On-ART Participants | -6 |
| D: Placebo Then Chloroquine for On-ART Participants | 7 |
Results reported are for entry fasting LPS. (NCT00819390)
Timeframe: At entry
| Intervention | pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 13.68 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.64 |
| C: Chloroquine Then Placebo for On-ART Participants | 8.00 |
| D: Placebo Then Chloroquine for On-ART Participants | 7.00 |
Results reported are the week 12 fasting LPS. (NCT00819390)
Timeframe: At week 12
| Intervention | pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 14.37 |
| B: Placebo Then Chloroquine for Off-ART Participants | 13.06 |
| C: Chloroquine Then Placebo for On-ART Participants | 7.00 |
| D: Placebo Then Chloroquine for On-ART Participants | 7.00 |
Results reported are the week 24 fasting LPS. (NCT00819390)
Timeframe: At week 24
| Intervention | pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 20.54 |
| B: Placebo Then Chloroquine for Off-ART Participants | 2.83 |
| C: Chloroquine Then Placebo for On-ART Participants | 7.00 |
| D: Placebo Then Chloroquine for On-ART Participants | 8.00 |
Results reported are for HIV-1 RNA (copies/mL) at study entry for off-ART participants. (NCT00819390)
Timeframe: At Entry
| Intervention | log10 copies/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 4.48 |
| B: Placebo Then Chloroquine for Off-ART Participants | 4.42 |
Events included signs and symptoms, laboratory abnormalities and/or clinical events grade 3 or higher which were described by site clinician blinded to the treatment arm as definitely or possibly related to the study treatment. (NCT00819390)
Timeframe: From start of study treatment to study completion at week 28
| Intervention | participants (Number) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1 |
| C: Chloroquine Then Placebo for On-ART Participants | 1 |
| D: Placebo Then Chloroquine for On-ART Participants | 0 |
Baseline CD4 HLA-DR+/CD38+ is computed as the mean of pre-entry and entry CD4 HLA-DR+/CD38+. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | percent of CD4 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 8.5 |
| B: Placebo Then Chloroquine for Off-ART Participants | 9.8 |
| C: Chloroquine Then Placebo for On-ART Participants | 8.7 |
| D: Placebo Then Chloroquine for On-ART Participants | 9.9 |
Results reported are the week 12 percentage of CD4 expressing HLA-DR+/CD38+. (NCT00819390)
Timeframe: At Week 12
| Intervention | percent of CD4 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 6.5 |
| B: Placebo Then Chloroquine for Off-ART Participants | 10.5 |
| C: Chloroquine Then Placebo for On-ART Participants | 7.7 |
| D: Placebo Then Chloroquine for On-ART Participants | 9.0 |
Results reported are the week 24 percentage of CD4 expressing HLA-DR+/CD38+. (NCT00819390)
Timeframe: At Week 24
| Intervention | percent of CD4 expressing HLA-DR+/CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 11.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 12.5 |
| C: Chloroquine Then Placebo for On-ART Participants | 7.3 |
| D: Placebo Then Chloroquine for On-ART Participants | 9.2 |
Baseline CD8 CD38+ is computed as the mean of pre-entry and entry CD8 CD38+. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | percent of CD8 expressing CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 71.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 77.0 |
| C: Chloroquine Then Placebo for On-ART Participants | 50.8 |
| D: Placebo Then Chloroquine for On-ART Participants | 49.9 |
Results reported are the week 12 percentage of CD8 expressing CD38+. (NCT00819390)
Timeframe: At Week 12
| Intervention | percent of CD8 expressing CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 71.5 |
| B: Placebo Then Chloroquine for Off-ART Participants | 79.5 |
| C: Chloroquine Then Placebo for On-ART Participants | 50.9 |
| D: Placebo Then Chloroquine for On-ART Participants | 51.9 |
Results reported are the week 24 percentage of CD8 expressing CD38+. (NCT00819390)
Timeframe: At Week 24
| Intervention | percent of CD8 expressing CD38+ (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 78.0 |
| B: Placebo Then Chloroquine for Off-ART Participants | 79.5 |
| C: Chloroquine Then Placebo for On-ART Participants | 50.6 |
| D: Placebo Then Chloroquine for On-ART Participants | 48.7 |
Baseline sCD14 was computed as the mean of pre-entry and entry sCD14. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | million pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 1.43 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.97 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.80 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.58 |
Results reported are the week 12 sCD14. (NCT00819390)
Timeframe: At week 12
| Intervention | million pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 1.53 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.88 |
| C: Chloroquine Then Placebo for On-ART Participants | 2.04 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.63 |
Results reported are the week 24 sCD14. (NCT00819390)
Timeframe: At week 24
| Intervention | million pg/mL (Median) |
|---|---|
| A: Chloroquine Then Placebo for Off-ART Participants | 1.53 |
| B: Placebo Then Chloroquine for Off-ART Participants | 2.19 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.77 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.72 |
Results reported are for HIV-1 RNA at study entry for on-ART participants. (NCT00819390)
Timeframe: At Entry
| Intervention | participants (Number) | |
|---|---|---|
| at or below lower limit of quantitation | above lower limit of quantitation | |
| C: Chloroquine Then Placebo for On-ART Participants | 16 | 2 |
| D: Placebo Then Chloroquine for On-ART Participants | 17 | 2 |
Results reported are for HIV-1 RNA at week 12 for on-ART participants. (NCT00819390)
Timeframe: At week 12
| Intervention | participants (Number) | |
|---|---|---|
| at or below lower limit of quantitation | above lower limit of quantitation | |
| C: Chloroquine Then Placebo for On-ART Participants | 16 | 1 |
| D: Placebo Then Chloroquine for On-ART Participants | 18 | 1 |
Results reported are for HIV-1 RNA at week 24 for on-ART participants. (NCT00819390)
Timeframe: At week 24
| Intervention | participants (Number) | |
|---|---|---|
| at or below lower limit of quantitation | above lower limit of quantitation | |
| C: Chloroquine Then Placebo for On-ART Participants | 14 | 2 |
| D: Placebo Then Chloroquine for On-ART Participants | 18 | 1 |
Results reported are for HIV-1 RNA (copies/mL) at week 12 and week 24 for off-ART participants. (NCT00819390)
Timeframe: At weeks 12 and 24
| Intervention | log10 copies/mL (Median) | |
|---|---|---|
| Week 12 | Week 24 | |
| A: Chloroquine Then Placebo for Off-ART Participants | 4.68 | 4.69 |
| B: Placebo Then Chloroquine for Off-ART Participants | 4.28 | 4.61 |
Baseline IL-6, sTNF-rI and D-dimer were computed as the mean of pre-entry and entry IL-6, sTNF-rI and D-dimer, respectively. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | pg/mL (Median) | ||
|---|---|---|---|
| IL-6 | sTNF-rI | D-dimer | |
| A: Chloroquine Then Placebo for Off-ART Participants | 1.65 | 1228.66 | 286390 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.62 | 1377.81 | 328460 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.01 | 1316.63 | 107890 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.51 | 1250.85 | 103530 |
Results reported are the week 12 IL-6, sTNF-rI and D-dimer. (NCT00819390)
Timeframe: At week 12
| Intervention | pg/mL (Median) | ||
|---|---|---|---|
| IL-6 | sTNF-rI | D-dimer | |
| A: Chloroquine Then Placebo for Off-ART Participants | 1.68 | 1209.50 | 251320 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.28 | 1347.06 | 319770 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.15 | 1441.35 | 126540 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.30 | 1304.77 | 117890 |
Results reported are the week 24 IL-6, sTNF-rI and D-dimer. (NCT00819390)
Timeframe: At week 24
| Intervention | pg/mL (Median) | ||
|---|---|---|---|
| IL-6 | sTNF-rI | D-dimer | |
| A: Chloroquine Then Placebo for Off-ART Participants | 1.34 | 1327.21 | 264240 |
| B: Placebo Then Chloroquine for Off-ART Participants | 1.18 | 1420.30 | 294780 |
| C: Chloroquine Then Placebo for On-ART Participants | 1.02 | 1230.21 | 100860 |
| D: Placebo Then Chloroquine for On-ART Participants | 1.27 | 1176.20 | 124920 |
Baseline percent activation levels of pDC were computed as the mean of pre-entry and entry percent activation levels of pDC. Similarly, baseline percent activation levels of mDC were computed as the mean of pre-entry and entry percent activation levels of mDC. (NCT00819390)
Timeframe: At pre-entry and entry
| Intervention | percentage of cells (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| %pDC expressing CD80+ | %pDC expressing CD83+ | %pDC expressing CD86+ | %pDC expressing PDL-1+ | %mDC expressing CD80+ | %mDC expressing CD83+ | %mDC expressing CD86+ | %mDC expressing PDL-1+ | |
| A: Chloroquine Then Placebo for Off-ART Participants | 0.03 | 45.48 | 9.12 | 2.52 | 1.04 | 38.60 | 96.29 | 9.82 |
| B: Placebo Then Chloroquine for Off-ART Participants | 0.03 | 36.15 | 9.35 | 6.13 | 0.83 | 39.94 | 97.52 | 16.37 |
| C: Chloroquine Then Placebo for On-ART Participants | 0.13 | 19.91 | 10.96 | 4.48 | 1.31 | 48.17 | 96.11 | 4.58 |
| D: Placebo Then Chloroquine for On-ART Participants | 0.07 | 23.65 | 12.66 | 6.49 | 1.17 | 26.08 | 95.38 | 8.28 |
Results reported are the week 12 percent activation levels of pDC and mDC. (NCT00819390)
Timeframe: At week 12
| Intervention | percentage of cells (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| %pDC expressing CD80+ | %pDC expressing CD83+ | %pDC expressing CD86+ | %pDC expressing PDL-1+ | %mDC expressing CD80+ | %mDC expressing CD83+ | %mDC expressing CD86+ | %mDC expressing PDL-1+ | |
| A: Chloroquine Then Placebo for Off-ART Participants | 0.00 | 51.90 | 7.66 | 3.74 | 0.84 | 43.51 | 97.90 | 15.03 |
| B: Placebo Then Chloroquine for Off-ART Participants | 0.05 | 40.49 | 8.48 | 8.43 | 1.03 | 36.47 | 97.18 | 16.32 |
| C: Chloroquine Then Placebo for On-ART Participants | 0.10 | 14.70 | 13.93 | 7.24 | 1.47 | 47.83 | 95.40 | 7.10 |
| D: Placebo Then Chloroquine for On-ART Participants | 0.14 | 18.20 | 13.64 | 5.16 | 1.01 | 26.75 | 95.15 | 6.09 |
Results reported are the week 24 percent activation levels of pDC and mDC. (NCT00819390)
Timeframe: At week 24
| Intervention | percentage of cells (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| %pDC expressing CD80+ | %pDC expressing CD83+ | %pDC expressing CD86+ | %pDC expressing PDL-1+ | %mDC expressing CD80+ | %mDC expressing CD83+ | %mDC expressing CD86+ | %mDC expressing PDL-1+ | |
| A: Chloroquine Then Placebo for Off-ART Participants | 0.05 | 44.50 | 10.13 | 4.34 | 0.94 | 41.21 | 97.70 | 9.53 |
| B: Placebo Then Chloroquine for Off-ART Participants | 0.00 | 38.96 | 7.89 | 7.45 | 1.12 | 33.19 | 97.05 | 14.84 |
| C: Chloroquine Then Placebo for On-ART Participants | 0.08 | 14.80 | 11.79 | 5.63 | 0.76 | 36.65 | 96.69 | 4.13 |
| D: Placebo Then Chloroquine for On-ART Participants | 0.16 | 17.65 | 12.88 | 6.52 | 1.39 | 24.14 | 92.41 | 7.49 |
"The time from first dosing to the first normal reading with fever clearance, defined as 2 consecutive assessments without fever (<37.5°C) taken between 8 and 24 hours apart.~NB: Time to fever clearance was only summarised for subjects who had fever at baseline or within the first 24 hours after the start of study treatment. Since only 12 subjects in total had fever during this time, the time to fever clearance estimates are not very meaningful." (NCT00331136)
Timeframe: Day 3
| Intervention | hours (Median) |
|---|---|
| Group A (Tablets) | 8.2 |
| Group B (Tablets) | 8.6 |
| Group C (Tablets) | 8.2 |
| Group D (Granules) | 8.2 |
Clearance of asexual parasitaemia within 7 days of initiation of study medication without recrudescence within 14 days. (NCT00331136)
Timeframe: Day 14
| Intervention | Participants (Count of Participants) |
|---|---|
| Group A (Tablets) | 11 |
| Group B (Tablets) | 13 |
| Group C (Tablets) | 15 |
| Group D (Granules) | 14 |
Clearance of asexual parasitaemia within 7 days of initiation of study medication without recrudescence within 42 days. (NCT00331136)
Timeframe: Day 42
| Intervention | Participants (Count of Participants) |
|---|---|
| Group A (Tablets) | 10 |
| Group B (Tablets) | 8 |
| Group C (Tablets) | 15 |
| Group D (Granules) | 13 |
The time from first dosing to the time of first blood draw with parasite clearance. Parasite clearance is defined as zero presence of parasites for 2 consecutive negative readings taken between 8 and 24 hours apart. (NCT00331136)
Timeframe: Day 3
| Intervention | hours (Median) |
|---|---|
| Group A (Tablets) | 16.4 |
| Group B (Tablets) | 16.1 |
| Group C (Tablets) | 8.1 |
| Group D (Granules) | 8.3 |
Clearance of asexual parasitaemia within 7 days of initiation of study medication without recrudescence within 28 days, without previously meeting any of the criteria for early treatment failure, late clinical failure, or late parasitological failure. (NCT00331136)
Timeframe: Day 28
| Intervention | Participants (Count of Participants) |
|---|---|
| Group A (Tablets) | 11 |
| Group B (Tablets) | 13 |
| Group C (Tablets) | 15 |
| Group D (Granules) | 14 |
The proportion of patients with crude (non-PCR corrected) ACPR. (NCT00331136)
Timeframe: Days 14, 28, 42
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Day 14 | Day 28 | Day 42 | |
| Group A (Tablets) | 11 | 11 | 7 |
| Group B (Tablets) | 13 | 10 | 6 |
| Group C (Tablets) | 15 | 15 | 13 |
| Group D (Granules) | 14 | 14 | 12 |
"The number of gametocytes per μl at Days 0, 3, 7, 14, 21, 28, 35, and 42 summarised from blood slides taken on the respective days.~P. falciparum gametocytes are responsible for transmission from host to vector." (NCT00331136)
Timeframe: Day 42
| Intervention | Participants (Count of Participants) | |||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | >0-24 hours | >24-48 hours | >48-72 hours | >72 hours - Day 7 | >Day 7 - Day 28 | >Day 28 - Day 42 | >Day 42 | |
| Group A (Tablets) | 2 | 3 | 2 | 2 | 2 | 1 | 0 | 0 |
| Group B (Tablets) | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
| Group C (Tablets) | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
| Group D (Granules) | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
"Patient without fever for 2 consecutive readings taken between 8 and 24 hours apart.~NB: Percentage of fever clearance was only summarised for subjects who had fever at baseline or within the first 24 hours after the start of study treatment. Since only 12 subjects in total had fever during this time, the time to fever clearance estimates are not very meaningful." (NCT00331136)
Timeframe: Days 1, 2, 3
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Clearance by >0 - 24 hours | Clearance by >24 - 48 hours | Clearance by >48 - 72 hours | No clearance achieved | |
| Group A (Tablets) | 3 | 0 | 0 | 0 |
| Group B (Tablets) | 5 | 0 | 0 | 0 |
| Group C (Tablets) | 3 | 0 | 0 | 0 |
| Group D (Granules) | 1 | 0 | 0 | 0 |
Passive surveillance to detect episode of fever (temperature > 37.5 C), or a history of fever within the past 48 hours, that is severe enough to require treatment at a health centre and which is accompanied by a positive blood film with a parasite density of 5,000 per µl or more (NCT03143218)
Timeframe: Passive surveillance of clinical episodes of malaria within the study area starting from the date of the first dose of study vaccines (April/May 2017) until 31st March 2020- a total of 36 months.
| Intervention | No. of events/1000 person years at risk (Number) |
|---|---|
| SMC With SP+AQ | 304.8 |
| RTS,S/AS01 | 278.2 |
| RTS,S/AS01 PLUS SMC With SP+AQ | 113.3 |
129 reviews available for chloroquine and Malaria, Falciparum
| Article | Year |
|---|---|
Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities.
Topics: Antimalarials; Crystallization; Drug Resistance; Heme; Hemeproteins; Humans; Malaria, Falciparum; Mo | 2013 |
Antimalarial application of quinones: A recent update.
Topics: Antimalarials; Dose-Response Relationship, Drug; Malaria, Falciparum; Molecular Structure; Parasitic | 2021 |
Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines.
Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Discovery; Female; Malaria, Falciparu | 2021 |
Methods Used to Investigate the
Topics: Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum; Vacuoles | 2021 |
Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review.
Topics: Africa South of the Sahara; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, F | 2022 |
Diagnosis, Treatment, and Prevention of Malaria in the US: A Review.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Humans; Malaria; Malar | 2022 |
Recent developments in antimalarial drug discovery.
Topics: Antimalarials; Chloroquine; Drug Resistance; Folic Acid Antagonists; Humans; Malaria; Malaria, Falci | 2023 |
Transition Metal Complexes as Antimalarial Agents: A Review.
Topics: Antimalarials; Chloroquine; Coordination Complexes; Drug Resistance; Humans; Malaria; Malaria, Falci | 2023 |
Pyronaridine: a review of its clinical pharmacology in the treatment of malaria.
Topics: Antimalarials; Child; Chloroquine; Female; Humans; Malaria; Malaria, Falciparum; Naphthyridines; Pre | 2023 |
Molecular Mechanisms of Drug Resistance in
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Tra | 2020 |
Current and emerging strategies to combat antimalarial resistance.
Topics: Antimalarials; Chloroquine; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Pl | 2022 |
pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies.
Topics: Aminoquinolines; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Therapy, Combinatio | 2017 |
Anti-malarial treatment outcomes in Ethiopia: a systematic review and meta-analysis.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Drug Combinatio | 2017 |
Mefloquine for preventing malaria during travel to endemic areas.
Topics: Adult; Antimalarials; Atovaquone; Child; Chloroquine; Doxycycline; Drug Combinations; Drug Resistanc | 2017 |
Primaquine or other 8-aminoquinolines for reducing Plasmodium falciparum transmission.
Topics: Adult; Antimalarials; Artemisinins; Child; Chloroquine; Drug Combinations; Glucosephosphate Dehydrog | 2018 |
Malaria Elimination: Time to Target All Species.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Disease Eradication; Host-Parasite Interactions; Hum | 2018 |
AQ-13 - an investigational antimalarial drug.
Topics: Animals; Antimalarials; Chloroquine; Drug Development; Drug Resistance; Drug Therapy, Combination; H | 2019 |
Persistence of chloroquine resistance alleles in malaria endemic countries: a systematic review of burden and risk factors.
Topics: Africa; Antimalarials; Asia; Chloroquine; Drug Resistance; Endemic Diseases; Gene Frequency; Genetic | 2019 |
Chemotherapy and drug resistance status of malaria parasite in northeast India.
Topics: Animals; Anopheles; Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Multiple; Drug Therap | 2013 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Malaria.
Topics: Africa South of the Sahara; Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate | 2014 |
Monitoring antimalarial drug efficacy in the Greater Mekong Subregion: an overview of in vivo results from 2008 to 2010.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Asia, Southeastern; Chloroquine; Directly Obser | 2013 |
Genetics of chloroquine-resistant malaria: a haplotypic view.
Topics: Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Haplotypes; Humans; Malaria, Falciparum | 2013 |
Primaquine or other 8-aminoquinoline for reducing P. falciparum transmission.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Glucosephosphate Dehydrogen | 2014 |
Is Plasmodium vivax malaria a severe malaria?: a systematic review and meta-analysis.
Topics: Adolescent; Adult; Anemia; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Ma | 2014 |
Primaquine or other 8-aminoquinoline for reducing Plasmodium falciparum transmission.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Glucosephosphate Dehydrogen | 2015 |
Fighting fire with fire: mass antimalarial drug administrations in an era of antimalarial resistance.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Therapy, Combination; History, 20th | 2015 |
WITHDRAWN: Drugs for preventing malaria in travellers.
Topics: Adult; Antimalarials; Atovaquone; Child; Chloroquine; Doxycycline; Drug Combinations; Drug Resistanc | 2015 |
The Treatment of Plasmodium knowlesi Malaria.
Topics: Antimalarials; Artemisinins; Artesunate; Asia, Southeastern; Chloroquine; Coinfection; Humans; Malar | 2017 |
Risk of drug resistance in Plasmodium falciparum malaria therapy-a systematic review and meta-analysis.
Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Drug Ther | 2017 |
Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Discovery; Humans; Malaria, Falcip | 2017 |
Lessons learnt from the six decades of chloroquine use (1945-2005) to control malaria in Madagascar.
Topics: Adolescent; Animals; Antimalarials; Artemisinins; Child; Chloroquine; Disease Outbreaks; Drug Resist | 2009 |
Azithromycin-chloroquine and the intermittent preventive treatment of malaria in pregnancy.
Topics: Africa South of the Sahara; Animals; Antimalarials; Azithromycin; Chloroquine; Drug Administration S | 2008 |
Drugs for preventing malaria in travellers.
Topics: Adult; Antimalarials; Atovaquone; Child; Chloroquine; Doxycycline; Drug Combinations; Drug Resistanc | 2009 |
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Design; Drug Interactions; Drug Sy | 2009 |
Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Drug Therapy, Combination; | 2010 |
Prospects of intermittent preventive treatment of adults against malaria in areas of seasonal and unstable malaria transmission, and a possible role for chloroquine.
Topics: Adult; Antimalarials; Carrier State; Chloroquine; Disease Outbreaks; Drug Resistance; Humans; Malari | 2010 |
Empowering malaria vaccination by drug administration.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria Vaccines; Malaria, Falciparum; Plasmodium falci | 2010 |
Artemisinin combination therapy for vivax malaria.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malari | 2010 |
Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; Drug Combinations; Drug Resis | 2010 |
PfCRT-mediated drug transport in malarial parasites.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transpor | 2011 |
Antimalarial drug resistance of Plasmodium falciparum in India: changes over time and space.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Drug Resistance; Geography; | 2011 |
Azithromycin for treating uncomplicated malaria.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Atovaquone; Azit | 2011 |
Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy.
Topics: Adult; Anti-Bacterial Agents; Antimalarials; Azithromycin; Chloroquine; Drug Therapy, Combination; F | 2011 |
The antimalarial ferroquine: from bench to clinic.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Clinical Trials, Phase II as Topic; Drug Resis | 2011 |
Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transpor | 2012 |
Primaquine for reducing Plasmodium falciparum transmission.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Glucosephosphate Dehydrogen | 2012 |
The need for new antimalarial drugs less prone to resistance.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Design; Drug Resistance; Drug Therapy, Combination; G | 2013 |
Malaria: a rising incidence in the United States.
Topics: Antimalarials; Chemoprevention; Chloroquine; Drug Combinations; Drug Resistance; Female; Global Heal | 2002 |
The pH of the Plasmodium falciparum digestive vacuole: holy grail or dead-end trail?
Topics: Acridine Orange; Animals; Antimalarials; Benzopyrans; Chloroquine; Drug Resistance; Erythrocytes; Fl | 2002 |
A novel transporter, Pfcrt, confers antimalarial drug resistance.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Gene Expression Regulation; Humans; Malaria, F | 2002 |
The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Antimetabolites; Chloroquine; Drug Resistance; Drug Resistance, Mult | 2003 |
Amodiaquine for treating malaria.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Combinations; Humans; Malaria, Falciparum; Pyrimethami | 2003 |
Chloroquine and artemisinin: six decades of research--what next?
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Genes, Protozoan; Humans; Malari | 2003 |
Safety evaluation of the drugs available to prevent malaria.
Topics: Adult; Animals; Antimalarials; Chemical and Drug Induced Liver Injury; Chloroquine; Humans; Malaria, | 2002 |
Monitoring antimalarial drug resistance: making the most of the tools at hand.
Topics: Animals; Antimalarials; Chloroquine; Drug Monitoring; Drug Resistance; Folic Acid Antagonists; Genet | 2003 |
Chemoresistance in falciparum malaria.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Endemic Diseases; F | 2003 |
WHO, the Global Fund, and medical malpractice in malaria treatment.
Topics: Africa; Antimalarials; Artemisinins; Child; Chloroquine; Drug Combinations; Drug Costs; Drug Resista | 2004 |
Management of severe malaria.
Topics: Adolescent; Age Distribution; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Com | 2004 |
Genetic and biochemical aspects of drug resistance in malaria parasites.
Topics: Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; Drug Resistance; Drug Resistance, Mul | 2004 |
Proteomic approaches to studying drug targets and resistance in Plasmodium.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Computational Biology; Computers; Drug Resistance | 2004 |
QTL analysis for discovery of genes involved in drug responses.
Topics: Alleles; Animals; Biological Evolution; Chloroquine; Chromosome Mapping; Drug Design; Drug Resistanc | 2004 |
Emerging drug--resistance and guidelines for treatment of malaria.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance, Multiple; Dru | 2004 |
Malaria in endemic areas.
Topics: Antimalarials; Artemether; Artemisinins; Blood Transfusion; Chloroquine; Deferoxamine; Drug Combinat | 2003 |
Plasmodium falciparum transmission rate and selection for drug resistance: a vexed association or a key to successful control?
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Insect Control; Insect Vectors; Malari | 2004 |
Antimalarial drug resistance in the Eastern Mediterranean Region.
Topics: Afghanistan; Animals; Antimalarials; Chloroquine; Djibouti; Drug Monitoring; Drug Resistance; Endemi | 2003 |
Drug resistant Plasmodium falciparum in an area of seasonal transmission.
Topics: Animals; Antimalarials; Chloroquine; Disease Transmission, Infectious; Drug Resistance, Multiple; Hu | 2005 |
pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Proteins | 2005 |
Contribution of the pfmdr1 gene to antimalarial drug-resistance.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Drug Resistance, Multiple; G | 2005 |
Malaria: uncomplicated, caused by Plasmodium falciparum.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Combina | 2005 |
[Malaria chemoprophylaxis].
Topics: Antimalarials; Atovaquone; Chloroquine; Contraindications; Doxycycline; Drug Combinations; Female; H | 2005 |
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.
Topics: Adult; Amodiaquine; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Mala | 2005 |
Antimalarial multi-drug resistance in Asia: mechanisms and assessment.
Topics: Animals; Antimalarials; Asia; ATP-Binding Cassette Transporters; Chloroquine; Dihydropteroate Syntha | 2005 |
[Cytochrome P-450 and the response to antimalarial drugs].
Topics: Administration, Oral; Adult; Amodiaquine; Animals; Antimalarials; Biotransformation; Child; Chloroqu | 2006 |
Comparative efficacy of chloroquine and sulphadoxine--pyrimethamine in pregnant women and children: a meta-analysis.
Topics: Adolescent; Adult; Africa; Antimalarials; Child; Chloroquine; Drug Combinations; Endemic Diseases; F | 2006 |
Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significance.
Topics: Africa; Amino Alcohols; Animals; Antimalarials; Artemisinins; Asia, Southeastern; Biological Transpo | 2006 |
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malar | 2006 |
Chloroquine resistance reversal agents as promising antimalarial drugs.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Proteins | 2006 |
Transporters involved in resistance to antimalarial drugs.
Topics: Animals; Antimalarials; Artemisinins; Calcium-Transporting ATPases; Chloroquine; Drug Resistance; Hu | 2006 |
Artemisinin and chloroquine: do mode of action and mechanism of resistance involve the same protagonists?
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drugs, Investigational; Humans; | 2007 |
Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Hydrogen-Ion Concentration; Malaria, Falciparu | 2007 |
Advances in understanding the genetic basis of antimalarial drug resistance.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Genome, Protozoan; Humans; Malaria, Falciparum | 2007 |
[Current malaria management in Switzerland].
Topics: Adult; Animals; Antimalarials; Chloroquine; Critical Care; Drug Resistance; Female; Humans; Malaria; | 1994 |
Deferoxamine treatment of malaria.
Topics: Animals; Chloroquine; Clinical Trials as Topic; Deferoxamine; Drug Resistance; Drug Therapy, Combina | 1994 |
Antimalarial 4-aminoquinolines: mode of action and pharmacokinetics.
Topics: Aminoquinolines; Animals; Antimalarials; Biotransformation; Chloroquine; Drug Resistance; Half-Life; | 1994 |
[Epidemiological stratification of malaria in Madagascar].
Topics: Agriculture; Animals; Anopheles; Chloroquine; Emigration and Immigration; Humans; Insect Vectors; Ma | 1993 |
Women and malaria--special risks and appropriate control strategy.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Developing Countries; Female; Humans; Ind | 1993 |
Malaria chemotherapy: resistance to quinoline containing drugs in Plasmodium falciparum.
Topics: Animals; Chloroquine; Humans; Insecticide Resistance; Malaria, Falciparum; Plasmodium falciparum | 1993 |
Clinical malaria in the tropics.
Topics: Africa; Antimalarials; Asia, Southeastern; Chloroquine; Combined Modality Therapy; Drug Resistance; | 1993 |
[Malaria: the most important emergency in subjects returning from the tropics].
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Emergencies; Humans; Malaria; Malaria, Falci | 1993 |
Prophylaxis against malaria for travellers from the United Kingdom. Malaria Reference Laboratory and the Ross Institute.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; H | 1993 |
Localized permanent epidemics: the genesis of chloroquine resistance in Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Asia, Southeastern; Chloroquine; Disease Outbreaks; Drug Resistance; | 1995 |
[Decision making policies on the utilization of antimalarials in response to a modification of chloroquine efficacity. Applications to Africa].
Topics: Africa; Antimalarials; Chloroquine; Decision Making, Organizational; Drug Resistance; Drug Utilizati | 1995 |
The treatment of malaria.
Topics: Adult; Antimalarials; Artemisinins; Child; Chloroquine; Drug Resistance; Female; Humans; Malaria; Ma | 1996 |
Molecular approaches to the spreading problem of drug resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Chromosome Mapping; DNA Fingerprinting; DNA, Protozoan; Drug Re | 1995 |
Systematic review of amodiaquine treatment in uncomplicated malaria.
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Randomized Controlled Trials a | 1996 |
Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Interactions; Drug Therapy, Combination; Malaria, Falc | 1996 |
Quinoline resistance mechanisms in Plasmodium falciparum: the debate goes on.
Topics: Aminoquinolines; Animals; Antimalarials; Biological Transport; Chloroquine; Drug Resistance; Malaria | 1997 |
[Malarone: newcomer in the treatment of malaria].
Topics: Antimalarials; Atovaquone; Chloroquine; Clinical Trials, Phase III as Topic; Drug Combinations; Drug | 1997 |
[The treatment of malaria].
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Malar | 1997 |
[Malaria therapy in the era of chloroquine resistance].
Topics: Antimalarials; Chloroquine; Clinical Trials as Topic; Drug Resistance; Drug Therapy, Combination; Hu | 1998 |
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine as a treatment for uncomplicated malaria--a systematic review.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Therapy, Combination; Humans; Malaria, Falciparum; Pyr | 1998 |
Malaria prevention in travelers.
Topics: Animals; Antimalarials; Bedding and Linens; Chloroquine; Doxycycline; Humans; Malaria; Malaria, Falc | 1999 |
The treatment of chloroquine-resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falcip | 1999 |
Na+/H+ antiporter, chloroquine uptake and drug resistance: inconsistencies in a newly proposed model.
Topics: Amiloride; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmo | 1999 |
Redox metabolism in glucose-6-phosphate dehydrogenase deficient erythrocytes and its relation to antimalarial chemotherapy.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Erythrocytes; Glucosephosphate Dehydrogenase D | 1999 |
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.
Topics: Adult; Amodiaquine; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Mala | 2000 |
[Malaria in Norway--diagnosis, treatment and prevention].
Topics: Antimalarials; Chloroquine; Humans; Insect Bites and Stings; Malaria; Malaria, Falciparum; Mefloquin | 2000 |
[Atovaquone/proguanil. Prophylaxis and treatment of malaria].
Topics: Antimalarials; Atovaquone; Chloroquine; Drug Combinations; Humans; Malaria, Falciparum; Naphthoquino | 2000 |
The challenge of chloroquine-resistant malaria in sub-Saharan Africa.
Topics: Africa South of the Sahara; Animals; Antimalarials; Chloroquine; Developing Countries; Disease Outbr | 2001 |
Antimalarial chemoprophylaxis in infants and children.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Doxycycline; Humans; Infant; Malaria, Falciparu | 2001 |
[Molecular aspects of chloroquine and antifols resistance in P. falciparum].
Topics: Animals; Antimalarials; Chloroquine; Folic Acid Antagonists; Humans; Incidence; Malaria, Falciparum; | 2001 |
Malaria chemoprophylaxis in the age of drug resistance. I. Currently recommended drug regimens.
Topics: Animals; Antimalarials; Atovaquone; Azithromycin; Chloroquine; Drug Resistance; Health Planning Guid | 2001 |
[Epidemiological and therapeutic aspects of plasmodial infection from Plasmodium vivax].
Topics: Antimalarials; Chloroquine; Clinical Protocols; Drug Resistance; Drug Therapy, Combination; Humans; | 2000 |
[Malaria--chemoprophylaxis 2001].
Topics: Africa; Antimalarials; Asia; Atovaquone; Chloroquine; Contraindications; Doxycycline; Drug Combinati | 2001 |
The rise and fall of malarial sporozoite rates in Anopheles gambiae s.l. and An. funestus in north-eastern Tanzania, between 1934 and 1999.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Climate; Drug Resistance; Female; Housing; Malaria, | 2001 |
Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Proteins | 2001 |
Chloroquine-resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Plasmodium; Plasmodium fa | 2001 |
The Italian army standpoint on malaria chemoprophylaxis.
Topics: Antimalarials; Chloroquine; Doxycycline; Drug Resistance; Drug Therapy, Combination; Endemic Disease | 2001 |
The malaria threat.
Topics: Antimalarials; Chloroquine; Doxycycline; Drug Resistance; Health Policy; Humans; Malaria; Malaria, F | 2001 |
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.
Topics: Adult; Amodiaquine; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Mala | 2001 |
Thioredoxin and glutathione system of malaria parasite Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Glutathione; Humans; Malaria, Fa | 2001 |
Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?
Topics: Africa South of the Sahara; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; | 2001 |
New developments: chloroquine-resistance in Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum | 2001 |
Combating malaria in Africa.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Ins | 2002 |
[Current status of research on chloroquine-resistant falciparum malaria].
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum | 1998 |
Drug resistance in malaria: a review of the west African situation.
Topics: Africa, Western; Animals; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falc | 1992 |
Plasmodium falciparum malaria in pregnancy: a review.
Topics: Animals; Chloroquine; Critical Care; Female; Humans; Immunocompromised Host; Malaria, Falciparum; Me | 1992 |
Development of the new antimalarial drug pyronaridine: a review.
Topics: Administration, Oral; Animals; Antimalarials; Cardiovascular System; Chloroquine; Dogs; Drug Evaluat | 1992 |
[The synthesis of the epidemiology and treatment of malaria of the pregnant woman and the infant in subsaharan Africa].
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Infant; Infant, Newbor | 1991 |
264 trials available for chloroquine and Malaria, Falciparum
| Article | Year |
|---|---|
Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria.
Topics: Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug | 2008 |
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
Topics: Antimalarials; Child; Child, Preschool; Cohort Studies; Drug Resistance; Humans; Malaria, Falciparum | 2010 |
Pharmacokinetics of chloroquine and monodesethylchloroquine in pregnancy.
Topics: Adolescent; Adult; Antimalarials; Area Under Curve; Bayes Theorem; Chloroquine; Dose-Response Relati | 2010 |
Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Eth | 2022 |
Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Eth | 2022 |
Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Eth | 2022 |
Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Eth | 2022 |
An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria inf
Topics: Adult; Antimalarials; Azithromycin; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans; | 2020 |
Immunogenicity and Protective Efficacy of Radiation-Attenuated and Chemo-Attenuated PfSPZ Vaccines in Equatoguinean Adults.
Topics: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Antimalarials; Child; Child, Preschool; Chl | 2021 |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial.
Topics: Adult; Antimalarials; Cell Line; Chemoprevention; Chloroquine; Female; Humans; Immunoglobulin G; Mal | 2021 |
In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections in Mozambican Adults: A Randomized, Placebo-controlled Trial with Implications for Elimination Strategies.
Topics: Adult; Antimalarials; Asymptomatic Infections; Chloroquine; Drug Resistance; Humans; Malaria, Falcip | 2017 |
Use of malaria rapid diagnostic tests by community health workers in Afghanistan: cluster randomised trial.
Topics: Adolescent; Afghanistan; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Communit | 2017 |
Effects of liver-stage clearance by Primaquine on gametocyte carriage of Plasmodium vivax and P. falciparum.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Blood; Child; Child, Prescho | 2017 |
Changing Antimalarial Drug Sensitivities in Uganda.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Aspartic Acid Endopeptidases; Child; Child, Pr | 2017 |
Placental but Not Peripheral Plasmodium falciparum Infection During Pregnancy Is Associated With Increased Risk of Malaria in Infancy.
Topics: Chloroquine; Drug Combinations; Female; Follow-Up Studies; Humans; Infant; Logistic Models; Longitud | 2017 |
Chloroquine is grossly under dosed in young children with malaria: implications for drug resistance.
Topics: Adolescent; Africa; Age Factors; Antimalarials; Child; Child, Preschool; Chloroquine; Dose-Response | 2014 |
Population pharmacokinetics of azithromycin and chloroquine in healthy adults and paediatric malaria subjects following oral administration of fixed-dose azithromycin and chloroquine combination tablets.
Topics: Adolescent; Adult; Africa South of the Sahara; Antimalarials; Azithromycin; Biological Availability; | 2014 |
Sporozoite immunization of human volunteers under mefloquine prophylaxis is safe, immunogenic and protective: a double-blind randomized controlled clinical trial.
Topics: Adolescent; Adult; Antibodies; Antimalarials; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes | 2014 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Temporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Ethanolamines; Female; Fluorenes; G | 2015 |
Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Azithromycin; Chloroquine; Drug Therapy, | 2014 |
Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Azithromycin; Chloroquine; Drug Therapy, | 2014 |
Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Azithromycin; Chloroquine; Drug Therapy, | 2014 |
Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Azithromycin; Chloroquine; Drug Therapy, | 2014 |
Comparison of azithromycin plus chloroquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in children in Africa: a randomized, open-label study.
Topics: Africa South of the Sahara; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; | 2015 |
Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites.
Topics: Adult; Chloroquine; Humans; Immunization; Malaria, Falciparum; Parasitemia; Plasmodium falciparum; S | 2015 |
Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission.
Topics: Adult; Antibodies, Protozoan; Antimalarials; Azithromycin; Chloroquine; Drug Combinations; Erythrocy | 2015 |
Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection.
Topics: Adult; Antibodies, Protozoan; Antimalarials; Chloroquine; Cryopreservation; Female; Humans; Injectio | 2015 |
High-Dose Chloroquine for Treatment of Chloroquine-Resistant Plasmodium falciparum Malaria.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falci | 2016 |
Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers Under Chloroquine Prophylaxis: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Animals; Anopheles; Antimalarials; Chloroquine; Cryopreservation; Double-Blind Me | 2016 |
Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial.
Topics: Adolescent; Adult; Azithromycin; Chloroquine; Drug Combinations; Female; Humans; Infant, Newborn; In | 2016 |
Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial.
Topics: Adolescent; Adult; Azithromycin; Chloroquine; Drug Combinations; Female; Humans; Infant, Newborn; In | 2016 |
Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial.
Topics: Adolescent; Adult; Azithromycin; Chloroquine; Drug Combinations; Female; Humans; Infant, Newborn; In | 2016 |
Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial.
Topics: Adolescent; Adult; Azithromycin; Chloroquine; Drug Combinations; Female; Humans; Infant, Newborn; In | 2016 |
Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa.
Topics: Adolescent; Adult; Africa South of the Sahara; Asymptomatic Diseases; Azithromycin; Chloroquine; Dru | 2016 |
The return of chloroquine-susceptible Plasmodium falciparum malaria in Zambia.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Cross-Sectional Studies; DNA, Protozoan; Drug Resista | 2016 |
Sterile protection against human malaria by chemoattenuated PfSPZ vaccine.
Topics: Adolescent; Adult; Antibodies, Protozoan; Chloroquine; Double-Blind Method; Healthy Volunteers; Huma | 2017 |
Sterile protection against human malaria by chemoattenuated PfSPZ vaccine.
Topics: Adolescent; Adult; Antibodies, Protozoan; Chloroquine; Double-Blind Method; Healthy Volunteers; Huma | 2017 |
Sterile protection against human malaria by chemoattenuated PfSPZ vaccine.
Topics: Adolescent; Adult; Antibodies, Protozoan; Chloroquine; Double-Blind Method; Healthy Volunteers; Huma | 2017 |
Sterile protection against human malaria by chemoattenuated PfSPZ vaccine.
Topics: Adolescent; Adult; Antibodies, Protozoan; Chloroquine; Double-Blind Method; Healthy Volunteers; Huma | 2017 |
Randomised controlled clinical trial of strychnos myrtoides extract for reversal of chloroquine resistance. (Comment on: Potential antimalarial activity of indole alkaloids).
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Double-Blind Method; Drug Resistance; | 2008 |
Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania.
Topics: Adolescent; Adult; Agranulocytosis; Amodiaquine; Analysis of Variance; Animals; Antimalarials; Chemi | 2008 |
Effects of chloroquine treatment on circulating erythropoietin and inflammatory cytokines in acute Plasmodium falciparum malaria.
Topics: Adult; Case-Control Studies; Chloroquine; Cytokines; Erythropoietin; Humans; Immunologic Factors; In | 2009 |
A trial of combination antimalarial therapies in children from Papua New Guinea.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Child, Preschool; Chloroquine; Drug Therapy, Co | 2008 |
Short report: comparison of chlorproguanil-dapsone with a combination of sulfadoxine-pyrimethamine and chloroquine in children with malaria in northcentral Nigeria.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Com | 2009 |
In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa.
Topics: Alleles; Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Chl | 2009 |
Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali.
Topics: Amodiaquine; Animals; Antigens, Protozoan; Antimalarials; Child; Child, Preschool; Chloroquine; Drug | 2009 |
Low efficacy of chloroquine: time to switchover to artemisinin-based combination therapy for falciparum malaria in India.
Topics: Adolescent; Adult; Aged; Animals; ATP-Binding Cassette Transporters; Child; Child, Preschool; Chloro | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Protection against a malaria challenge by sporozoite inoculation.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Biomarkers; Blood; Chloroquine; Dou | 2009 |
Artemisinin-naphthoquine combination (ARCO) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: a preliminary report on safety and efficacy.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Blood; Chloroquine; Drug Combinations; Huma | 2009 |
Potential toxicity of chlorpheniramine plus chloroquine for the treatment of childhood malaria.
Topics: Adolescent; Antimalarials; Antipruritics; Chi-Square Distribution; Child; Child, Preschool; Chloroqu | 2009 |
Placental malaria and low birth weight in pregnant women living in a rural area of Burkina Faso following the use of three preventive treatment regimens.
Topics: Adult; Animals; Antimalarials; Burkina Faso; Chemoprevention; Chloroquine; Drug Combinations; Female | 2009 |
Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance.
Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Chi | 2010 |
Evaluation of chloroquine therapy for vivax and falciparum malaria in southern Sumatra, western Indonesia.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Fe | 2010 |
Comparative study of efficacy of artesunate plus cotrimoxazole and artesunate plus chloroquine in the treatment of malaria in Nigerian children: a preliminary report.
Topics: Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug Therapy, Combina | 2010 |
Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial.
Topics: Adolescent; Amino Acid Substitution; Antimalarials; Artemether, Lumefantrine Drug Combination; Artem | 2011 |
Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study.
Topics: Adaptive Immunity; Adult; Antibody Specificity; Antimalarials; Chloroquine; Female; Humans; Immuniza | 2011 |
Efficacy of chloroquine and sulphadoxine-pyrimethamine either alone or in combination before introduction of ACT as first-line therapy in uncomplicated Plasmodium falciparum malaria in Jalpaiguri District, West Bengal, India.
Topics: Adolescent; Adult; Anti-Infective Agents; Antimalarials; Artemisinins; Child; Chloroquine; Drug Comb | 2011 |
Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan.
Topics: Adolescent; Adult; Afghanistan; Aged; Aged, 80 and over; Animals; Antimalarials; Blood; Child; Child | 2011 |
Effect of transmission reduction by insecticide-treated bednets (ITNs) on antimalarial drug resistance in western Kenya.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Female; Ge | 2011 |
Defining Plasmodium falciparum treatment in South West Asia: a randomized trial comparing artesunate or primaquine combined with chloroquine or SP.
Topics: Adolescent; Antimalarials; Artemisinins; Artesunate; Child; Chloroquine; Drug Combinations; Drug Res | 2012 |
Effects of malaria volunteer training on coverage and timeliness of diagnosis: a cluster randomized controlled trial in Myanmar.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemether, Lumefantrine Drug Combination | 2012 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Chloroquine for the treatment of uncomplicated malaria in Guyana.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Follow-Up St | 2002 |
Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, Indonesia.
Topics: Antimalarials; Chloroquine; Drug Therapy, Combination; Humans; Incidence; Indonesia; Malaria, Falcip | 2002 |
In vivo drug resistance of falciparum malaria in mining areas of Venezuela.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Female; Health Promo | 2002 |
Effect of zinc on the treatment of Plasmodium falciparum malaria in children: a randomized controlled trial.
Topics: Animals; Child, Preschool; Chloroquine; Double-Blind Method; Ecuador; Fever; Ghana; Hospitalization; | 2002 |
Treatment of children with Plasmodium falciparum malaria with chloroquine in Guinea-Bissau.
Topics: Antimalarials; Child; Chloroquine; Guinea-Bissau; Humans; Malaria, Falciparum | 2002 |
Tolerability of doxycycline monohydrate salt vs. chloroquine-proguanil in malaria chemoprophylaxis.
Topics: Adult; Animals; Antimalarials; Chad; Chloroquine; Doxycycline; Drug Therapy, Combination; France; Ga | 2002 |
Chloroquine and sulphadoxine-pyrimethamine efficacy for uncomplicated malaria treatment and haematological recovery in children in Bobo-Dioulasso, Burkina Faso during a 3-year period 1998-2000.
Topics: Anemia; Animals; Antimalarials; Burkina Faso; Child, Preschool; Chloroquine; Drug Combinations; Drug | 2002 |
The effects of chloroquine, amodiaquine and chloroquine plus chlorpheniramine on the disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children.
Topics: Acute Disease; Adolescent; Amodiaquine; Antimalarials; Area Under Curve; Child; Child, Preschool; Ch | 2002 |
The efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria in Laos.
Topics: Acute Disease; Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Fema | 2002 |
[Chemosensitivity of Plasmodium falciparum in Sainte Marie island, east coast of Madagascar: in vivo and in vitro studies].
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; | 2000 |
Therapeutic efficacy of chloroquine plus sulphadoxine/ pyrimethamine compared with monotherapy with either chloroquine or sulphadoxine/pyrimethamine in uncomplicated Plasmodium falciparum malaria in Laos.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Dru | 2003 |
Efficacy of chloroquine, sulfadoxine-pyrimethamine, and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria on the north coast of Peru.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; | 2003 |
Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia.
Topics: Adolescent; Adult; Animals; Antimalarials; Chi-Square Distribution; Child, Preschool; Chloroquine; C | 2002 |
Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinatio | 2003 |
[In vivo evaluation of chloroquine therapeutic efficacy in uncomplicated Plasmodium falciparum malaria in Central African Republic ine 1997 and 1998].
Topics: Administration, Oral; Antimalarials; Central African Republic; Chloroquine; Drug Resistance; Endemic | 2003 |
A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.
Topics: Acute Disease; Administration, Oral; Amodiaquine; Analysis of Variance; Antimalarials; Child; Child, | 2003 |
The addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children delays, but does not prevent treatment failure.
Topics: Age Factors; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; | 2003 |
Efficacy of chloroquine in the treatment of uncomplicated Plasmodium falciparum infection in East Timor, 2000.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Fe | 2003 |
Plasmodium falciparum gametocytaemia in Nigerian children: before, during and after treatment with antimalarial drugs.
Topics: Age Factors; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combina | 2003 |
Malaria in a cohort of Javanese migrants to Indonesian Papua.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Cross-Sectional Studies; Female; Follow-Up Stu | 2003 |
Assessing the efficacy of chloroquine and sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in the Democratic Republic of Congo.
Topics: Antimalarials; Child, Preschool; Chloroquine; Democratic Republic of the Congo; Drug Combinations; D | 2003 |
N'Dribala (Cochlospermum planchonii) versus chloroquine for treatment of uncomplicated Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Antimalarials; Bixaceae; Child; Chloroquine; Female; Humans; Malaria, Falciparum; | 2003 |
Chloroquine versus sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum malaria in Savannakhet Province, Lao People's Democratic Republic: an assessment of national antimalarial drug recommendations.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Female; | 2003 |
Treatment of uncomplicated falciparum malaria in southern Vietnam: can chloroquine or sulfadoxine-pyrimethamine be reintroduced in combination with artesunate?
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Child; Chloroquine; Drug Combin | 2003 |
Artemether bioavailability after oral or intramuscular administration in uncomplicated falciparum malaria.
Topics: Administration, Oral; Adolescent; Adult; Antimalarials; Area Under Curve; Artemether; Artemisinins; | 2003 |
Antipyretic, parasitologic, and immunologic effects of combining sulfadoxine/pyrimethamine with chloroquine or paracetamol for treating uncomplicated Plasmodium falciparum malaria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Body Temperature; Child, Preschool; | 2003 |
The efficacy of chloroquine, sulfadoxine-pyrimethamine and a combination of both for the treatment of uncomplicated Plasmodium falciparum malaria in an area of low transmission in western Uganda.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resi | 2004 |
Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes.
Topics: Acute Disease; Age Factors; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate; Child; Chil | 2004 |
Efficacy of chloroquine, amodiaquine, sulphadoxine-pyrimethamine and combination therapy with artesunate in Mozambican children with non-complicated malaria.
Topics: Amodiaquine; Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Therapy, | 2004 |
Efficacy of sulphadoxine-pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan children.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Huma | 2004 |
Antimalarial efficacy of sulfadoxine-pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine-pyrimethamine in Bundi Bugyo, western Uganda.
Topics: Amodiaquine; Antimalarials; Child, Preschool; Chloroquine; Developing Countries; Drug Combinations; | 2004 |
Patterns of resistance and DHFR/DHPS genotypes of Plasmodium falciparum in rural Tanzania prior to the adoption of sulfadoxine-pyrimethamine as first-line treatment.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Developing Countries; Dihydropteroate Synthas | 2004 |
Efficacy of combined chloroquine and sulfadoxine-pyrimethamine in uncomplicated Plasmodium falciparum malaria in Bangladesh.
Topics: Administration, Oral; Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug C | 2004 |
[Gametocyte levels in response to differing malaria treatments in two municipalities of Colombia].
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Colombia; Dru | 2004 |
A prospective study evaluating the efficacy of a single, 45-mg dose of primaquine, as a gametocytocidal agent, in patients with Plasmodium falciparum malaria in Mumbai, India.
Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Drug Administration Schedule; Drug Therapy, Com | 2004 |
Low-dose quinine is effective in the treatment of chloroquine-resistant Plasmodium falciparum malaria in eastern Sudan.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Administration Sc | 2004 |
Efficacy of chloroquine, sulphadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in Kajo Keji county, Sudan.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Therapy, C | 2004 |
[Therapeutic efficiency of chloroquine in the savannah region in the north of Côte d'Ivoire (1997)].
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Cote d'Ivoire; Humans; Infant; Malaria, Falcipa | 2004 |
Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children.
Topics: Amodiaquine; Animals; Antimalarials; Carrier State; Child; Child, Preschool; Chloroquine; Chlorpheni | 2004 |
Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic.
Topics: Adolescent; Adult; Antimalarials; Artemether; Artemisinins; Artesunate; Child; Child, Preschool; Chl | 2004 |
Plasmodium falciparum hyperparasitaemia in children. Risk factors, treatment outcomes, and gametocytaemia following treatment.
Topics: Age Factors; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combina | 2004 |
Comparison of the in-vitro activity of amodiaquine and its main metabolite, monodesethyl-amodiaquine, in Plasmodium falciparum.
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Cell Proliferation; Chloroquine; Dose-Respon | 2003 |
Clinical and parasitological response of Plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine in rural Uganda.
Topics: Adult; Animals; Antimalarials; Cell Proliferation; Child, Preschool; Chloroquine; Drug Combinations; | 2003 |
Efficacies of chloroquine, sulfadoxine-pyrimethamine and quinine in the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resi | 2004 |
Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar.
Topics: Adolescent; Adult; Age Distribution; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschoo | 2004 |
Pharmacokinetic interaction of chloroquine and methylene blue combination against malaria.
Topics: Administration, Oral; Adult; Anti-Infective Agents, Urinary; Antimalarials; Area Under Curve; Chloro | 2004 |
Safety of the combination of chloroquine and methylene blue in healthy adult men with G6PD deficiency from rural Burkina Faso.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Glucosephosphate Dehydroge | 2005 |
Evidence basis for antimalarial policy change in Sierra Leone: five in vivo efficacy studies of chloroquine, sulphadoxine-pyrimethamine and amodiaquine.
Topics: Amodiaquine; Animals; Antimalarials; Child, Preschool; Chloroquine; Developing Countries; Drug Combi | 2005 |
A randomized comparative study of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Ghana.
Topics: Amodiaquine; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Female; Fever; Ghana; | 2005 |
A randomized comparison of sulphadoxine-pyrimethamine and combination of sulphadoxine pyrimethamine with chloroquine in the treatment of uncomplicated falciparum malaria in Eastern Sudan.
Topics: Adolescent; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malari | 2005 |
Plasma zinc concentrations are depressed during the acute phase response in children with falciparum malaria.
Topics: Antimalarials; Child, Preschool; Chloroquine; Dietary Supplements; Female; Humans; Infant; Malaria, | 2005 |
Therapeutic efficacy of antimalarial drugs along the eastern Indo-Nepal border: a cross-border collaborative study.
Topics: Adolescent; Adult; Age Distribution; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combi | 2005 |
A multicenter study of azithromycin, alone and in combination with chloroquine, for the treatment of acute uncomplicated Plasmodium falciparum malaria in India.
Topics: Adolescent; Adult; Aged; Antimalarials; Azithromycin; Chloroquine; Double-Blind Method; Drug Therapy | 2005 |
Reduction of malaria transmission to Anopheles mosquitoes with a six-dose regimen of co-artemether.
Topics: Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Female; | 2005 |
Malaria in the Nuba Mountains of Sudan: baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine-pyrimethamine and artesunate plus amodiaquine combinations.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Chloroquine; Drug Combinatio | 2005 |
Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulfadoxine-pyrimethamine + artesunate in Huambo and Bie provinces, central Angola.
Topics: Amodiaquine; Angola; Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Chloroquine | 2005 |
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Therapy, C | 2005 |
Efficacy of combination therapy with artesunate plus amodiaquine compared to monotherapy with chloroquine, amodiaquine or sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum in Afghanistan.
Topics: Adolescent; Adult; Afghanistan; Aged; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; C | 2005 |
Predictors of the failure of treatment with chloroquine plus chlorpheniramine, in children with acute, uncomplicated, Plasmodium falciparum malaria.
Topics: Acute Disease; Age Factors; Antimalarials; Child; Child, Preschool; Chloroquine; Chlorpheniramine; D | 2005 |
Quinine for the treatment of chloroquine-resistant Plasmodium falciparum malaria in pregnant and non-pregnant Sudanese women.
Topics: Adult; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans | 2005 |
In vivo and in vitro analysis of chloroquine resistance in Plasmodium falciparum isolates from Senegal.
Topics: Adolescent; Adult; Animals; Antiparasitic Agents; ATP-Binding Cassette Transporters; Chloroquine; DN | 2005 |
In vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in Plasmodium falciparum isolates from the Republic of Congo.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Congo; DNA, Protozoan; Genotype; Human | 2005 |
Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Chloroquine; Drug Combinatio | 2005 |
Efficacy of chloroquine + sulfadoxine--pyrimethamine, mefloquine + artesunate and artemether + lumefantrine combination therapies to treat Plasmodium falciparum malaria in the Chittagong Hill Tracts, Bangladesh.
Topics: Adolescent; Antimalarials; Artemether; Artemisinins; Artesunate; Bangladesh; Child; Child, Preschool | 2005 |
The drug sensitivities of Plasmodium falciparum in the Sonitpur district, Assam, India.
Topics: Adolescent; Adult; Age Factors; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug C | 2005 |
Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].
Topics: Burkina Faso; Child, Preschool; Chloroquine; Drug Therapy, Combination; Glycogen Storage Disease Typ | 2005 |
Pre-treatment with chloroquine and parasite chloroquine resistance in Ghanaian children with severe malaria.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Genotype; Gha | 2005 |
Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug Com | 2005 |
[Evaluation of the therapeutic efficacy of amodiaquine versus chloroquine in the treatment of uncomplicated malaria in Abie, Côte-d'Ivoire].
Topics: Amodiaquine; Animals; Antimalarials; Child, Preschool; Chloroquine; Cote d'Ivoire; Drug Combinations | 2005 |
A randomized trial comparing the efficacy of four treatment regimens for uncomplicated falciparum malaria in Assam state, India.
Topics: Adolescent; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Drug Comb | 2006 |
Response to chloroquine treatment in children with or without gametocytes during uncomplicated Plasmodium falciparum malaria.
Topics: Antimalarials; Chloroquine; Germ Cells; Humans; Malaria, Falciparum | 2006 |
Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance.
Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Comb | 2006 |
A randomized, double-blind, placebo-controlled, clinical trial of the impact of malaria prevention on the educational attainment of school children.
Topics: Achievement; Adolescent; Animals; Antimalarials; Child; Chloroquine; Cognition; Double-Blind Method; | 2006 |
Lack of a pharmacokinetic interaction between azithromycin and chloroquine.
Topics: Adult; Animals; Antimalarials; Area Under Curve; Azithromycin; Chloroquine; Drug Interactions; Drug | 2006 |
Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia.
Topics: Adult; Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Indonesia; Japan; Malaria, Falcip | 2006 |
Efficacy of chloroquine and sulfadoxine/pyrimethamine for the treatment of uncomplicated falciparum malaria in Koumantou, Mali.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Female; Humans; Infant; Malaria, Falcip | 2006 |
Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau: implications for future treatment recommendations.
Topics: Adolescent; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Dose-Response Relation | 2007 |
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine.
Topics: Burkina Faso; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Drug Therapy, Combina | 2006 |
Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antimalarials; Child; Child, Preschool; Chloroq | 2007 |
Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial.
Topics: Adult; Amodiaquine; Antimalarials; Chloroquine; Drug Administration Schedule; Drug Combinations; Fem | 2006 |
Return of chloroquine antimalarial efficacy in Malawi.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Endemic D | 2006 |
Combined chloroquine, sulfadoxine/pyrimethamine and primaquine against Plasmodium falciparum in Central Java, Indonesia.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination | 2006 |
Improved efficacy with amodiaquine instead of chloroquine in sulfadoxine/pyrimethamine combination treatment of falciparum malaria in Uganda: experience with fixed-dose formulation.
Topics: Amodiaquine; Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Administration Schedule; Dr | 2006 |
Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Anemia; Antimalarials; Child Development; Chloroquine; Double-Blind Method; Femal | 2007 |
Thiamin deficiency and uncomplicated falciparum malaria in Laos.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artesunate; Beriberi; Child | 2007 |
Is chloroquine chemoprophylaxis still effective to prevent low birth weight? Results of a study in Benin.
Topics: Adult; Anemia; Antimalarials; Bedding and Linens; Benin; Birth Weight; Chloroquine; Drug Administrat | 2007 |
[Surveillance of falciparum malaria susceptibility to antimalarial drugs and policy change in the Comoros].
Topics: Animals; Antimalarials; Artemether; Artemisinins; Child; Child, Preschool; Chloroquine; Clinical Pro | 2007 |
Sulfadoxine-pyrimethamine efficacy and selection of Plasmodium falciparum DHFR mutations in Burkina Faso before its introduction as intermittent preventive treatment for pregnant women.
Topics: Adolescent; Animals; Antimalarials; Burkina Faso; Child; Child, Preschool; Chloroquine; Drug Adminis | 2007 |
Unusual pattern of Plasmodium falciparum drug resistance in the northwestern Peruvian Amazon region.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; | 2007 |
Plasmodium falciparum genotypes associated with chloroquine and amodiaquine resistance in Guinea-Bissau.
Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistan | 2007 |
Randomized clinical trial of artemisinin versus non-artemisinin combination therapy for uncomplicated falciparum malaria in Madagascar.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroqui | 2007 |
Children in Burkina Faso who are protected by insecticide-treated materials are able to clear drug-resistant parasites better than unprotected children.
Topics: Animals; Antimalarials; Bedding and Linens; Burkina Faso; Child, Preschool; Chloroquine; Drug Resist | 2007 |
Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Genotype; Heterodup | 2007 |
A comparison of sulfadoxine-pyrimethamine with chloroquine and pyrimethamine for prevention of malaria in pregnant Nigerian women.
Topics: Adult; Animals; Antimalarials; Birth Weight; Chloroquine; Drug Combinations; Female; Hematocrit; Hum | 2007 |
Efficacy of artesunate plus amodiaquine, artesunate plus sulfadoxine-pyrimethamine, and chloroquine plus sulfadoxine-pyrimethamine in patients with uncomplicated Plasmodium falciparum in the Comoros Union.
Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child | 2007 |
Dramatically decreased therapeutic efficacy of chloroquine and sulfadoxine-pyrimethamine, but not mefloquine, in southern Benin.
Topics: Administration, Oral; Animals; Antigens, Protozoan; Antimalarials; Benin; Child, Preschool; Chloroqu | 2007 |
Sulfadoxine-pyrimethamine plus artesunate compared with chloroquine for the treatment of vivax malaria in areas co-endemic for Plasmodium falciparum and P. vivax: a randomised non-inferiority trial in eastern Afghanistan.
Topics: Adolescent; Afghanistan; Antimalarials; Artemisinins; Artesunate; Child; Chloroquine; Drug Combinati | 2007 |
[Open radomized study comparing chloroquine and amodiaquine for treatment of uncomplicated plasmodium falciparum malaria in children in Aboisso, Cote d' Ivoire].
Topics: Amodiaquine; Antimalarials; Child, Preschool; Chloroquine; Cote d'Ivoire; Female; Humans; Infant; Ma | 2007 |
Comparison of the therapeutic efficacy of chloroquine and sulphadoxine-pyremethamine in children and pregnant women.
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Female; Humans; Malaria, Falciparum | 2007 |
Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea.
Topics: Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug R | 2007 |
Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa.
Topics: Analysis of Variance; Anemia; Animals; Antimalarials; Artemisinins; Artesunate; Benin; Child, Presch | 2007 |
Comparative study of interactions between chloroquine and chlorpheniramine or promethazine in healthy volunteers: a potential combination-therapy phenomenon for resuscitating chloroquine for malaria treatment in Africa.
Topics: Adult; Animals; Antimalarials; Area Under Curve; Chloroquine; Chlorpheniramine; Chromatography, High | 2008 |
[Randomized clinical trial of two malaria prophylaxis regimens for pregnant women in Faladie, Mali].
Topics: Adult; Anemia; Antimalarials; Chloroquine; Drug Combinations; Endemic Diseases; Female; Humans; Infa | 2007 |
Population pharmacokinetics of chloroquine and sulfadoxine and treatment response in children with malaria: suggestions for an improved dose regimen.
Topics: Animals; Anti-Infective Agents; Antimalarials; Child, Preschool; Chloroquine; Dose-Response Relation | 2008 |
Randomised placebo-controlled trial of primaquine for prophylaxis of falciparum and vivax malaria.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Double-Blind Method; Drug Administration Schedule; Hu | 1995 |
Randomised placebo-controlled trial of primaquine for prophylaxis of falciparum and vivax malaria.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Double-Blind Method; Drug Administration Schedule; Hu | 1995 |
Randomised placebo-controlled trial of primaquine for prophylaxis of falciparum and vivax malaria.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Double-Blind Method; Drug Administration Schedule; Hu | 1995 |
Randomised placebo-controlled trial of primaquine for prophylaxis of falciparum and vivax malaria.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Double-Blind Method; Drug Administration Schedule; Hu | 1995 |
Comparison of three malaria chemoprophylactic regimens in residents in east, central and southern Africa. A prospective, randomized multicentre trial in The Netherlands.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Administration Schedule; Drug Therapy, Combination | 1995 |
Efficacy and tolerance in adults of a short (3 days) course of quinine for uncomplicated falciparum malaria.
Topics: Adolescent; Adult; Antimalarials; Cameroon; Chloroquine; Drug Tolerance; Female; Humans; Malaria, Fa | 1995 |
Response of Plasmodium falciparum to chloroquine and Fansidar in vivo and chloroquine and amodiaquine in vitro in Uganda.
Topics: Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Evaluation, Preclin | 1995 |
Antibodies to ring-infected erythrocyte surface antigen (Pf155/RESA) protect against P. falciparum parasitemia in highly exposed multigravidas women in Malawi.
Topics: Adult; Amino Acid Sequence; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; | 1994 |
Primaquine for prophylaxis against malaria among nonimmune transmigrants in Irian Jaya, Indonesia.
Topics: Adolescent; Adult; Animals; Anopheles; Child; Chloroquine; Confounding Factors, Epidemiologic; Drug | 1995 |
Daily primaquine is effective for prophylaxis against falciparum malaria in Kenya: comparison with mefloquine, doxycycline, and chloroquine plus proguanil.
Topics: Adolescent; Child; Chloroquine; Doxycycline; Drug Administration Schedule; Humans; Kenya; Malaria, F | 1995 |
Specific and nonspecific responses to Plasmodium falciparum blood-stage parasites and observations on the gametocytemia in schoolchildren living in a malaria-endemic area of Mozambique.
Topics: Adolescent; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Blotting, Western; C | 1995 |
[Parasitological and clinical response to amodiaquine versus chloroquine in the treatment of Plasmodium falciparum malaria in children in an endemic area].
Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Infa | 1994 |
In vivo sensitivity of Plasmodium falciparum to chloroquine, amodiaquine and sulfadoxine-pyrimethamine in western Uganda.
Topics: Adult; Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; | 1994 |
Classification of clinical falciparum malaria and its use for the evaluation of chemosuppression in children under six years of age in Liberia, west Africa.
Topics: Anemia; Body Temperature; Child, Preschool; Chloroquine; Cohort Studies; Female; Humans; Infant; Lib | 1993 |
Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum.
Topics: Administration, Oral; Adolescent; Adult; Azithromycin; Chloroquine; Drug Administration Schedule; Dr | 1994 |
Prevention of Plasmodium falciparum malaria by Fansimef and Lariam in the northeastern part of Thailand.
Topics: Adult; Animals; Antibodies, Protozoan; Blood; Chloroquine; Drug Combinations; Humans; Malaria, Falci | 1993 |
A comparison of amodiaquine and chloroquine in the treatment therapy of falciparum malaria in Kenya.
Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Costs; Humans; Kenya; Mal | 1994 |
The efficacy of antimalarial regimens containing sulfadoxine-pyrimethamine and/or chloroquine in preventing peripheral and placental Plasmodium falciparum infection among pregnant women in Malawi.
Topics: Analysis of Variance; Antimalarials; Chi-Square Distribution; Chloroquine; Drug Combinations; Drug T | 1994 |
Comparison of micronized halofantrine with chloroquine-antibiotic combinations for treating Plasmodium falciparum malaria in adults from Gabon.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antimalarials; Chloroquine; Clindamycin; Doxycycline; | 1994 |
High dose chloroquine versus micronized halofantrine in chloroquine-resistant Plasmodium falciparum malaria.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Ma | 1994 |
Chloroquine chemoprophylaxis in children during peak transmission period in Ethiopia.
Topics: Adolescent; Age Distribution; Child; Child, Preschool; Chloroquine; Drug Resistance; Ethiopia; Follo | 1994 |
Long-term malaria prophylaxis with weekly mefloquine.
Topics: Africa, Western; Chloroquine; Cohort Studies; Drug Administration Schedule; Drug Therapy, Combinatio | 1993 |
Mefloquine or doxycycline prophylaxis in US troops in Somalia.
Topics: Animals; Chloroquine; Doxycycline; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Militar | 1993 |
Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon.
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Clindamycin; Drug Therapy, Combination; Female; Ga | 1994 |
Comparison of three regimens for malaria prophylaxis in travellers to east, central, and southern Africa.
Topics: Africa, Central; Africa, Eastern; Africa, Southern; Animals; Chloroquine; Dose-Response Relationship | 1993 |
Chloroquine and sulfadoxine/pyrimethamine sensitivity in Burkina Faso. In vivo sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine in Burkina Faso.
Topics: Animals; Burkina Faso; Child; Child, Preschool; Chloroquine; Drug Resistance; Drug Therapy, Combinat | 1994 |
Response of falciparum malaria to chloroquine and three second line antimalarial drugs in a Kenyan coastal school age population.
Topics: Adolescent; Amodiaquine; Child; Chloroquine; Drug Combinations; Drug Resistance; Humans; Kenya; Mala | 1993 |
Curing of chloroquine-resistant malaria with clindamycin.
Topics: Adolescent; Adult; Aged; Animals; Chloroquine; Clindamycin; Drug Resistance; Female; Follow-Up Studi | 1993 |
Tolerability of prophylactic Lariam regimens.
Topics: Adult; Anorexia; Chloroquine; Depression; Dizziness; Double-Blind Method; Dreams; Drug Tolerance; Ey | 1993 |
Postexposure administration of halofantrine for the prevention of malaria.
Topics: Administration, Oral; Adult; Antimalarials; Chloroquine; Drug Administration Schedule; Humans; Malar | 1993 |
Plasmodium falciparum sensitivity to antimalarials at Humera, northwestern Ethiopia.
Topics: Adolescent; Adult; Animals; Child; Chloroquine; Drug Combinations; Drug Resistance; Ethiopia; Female | 1993 |
In vivo sensitivity of Plasmodium falciparum to halofantrine hydrochloride in Burkina Faso.
Topics: Alanine Transaminase; Animals; Antimalarials; Aspartate Aminotransferases; Bilirubin; Burkina Faso; | 1994 |
Resistance of Plasmodium falciparum to antimalarial drugs in Equatorial Guinea.
Topics: Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug R | 1993 |
Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa.
Topics: Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Follow-Up Studies; Hemogl | 1993 |
Recent military experience with malaria chemoprophylaxis.
Topics: Antimalarials; Australia; Chloroquine; Dapsone; Doxycycline; Drug Administration Schedule; Drug Comb | 1993 |
Malaria chemosuppression in pregnancy. I. The effect of chemosuppressive drugs on maternal parasitaemia.
Topics: Adolescent; Adult; Animals; Chloroquine; Drug Combinations; Female; Humans; Malaria, Falciparum; Pla | 1993 |
Randomised trial of pyronaridine versus chloroquine for acute uncomplicated falciparum malaria in Africa.
Topics: Administration, Oral; Adolescent; Adult; Animals; Antimalarials; Cameroon; Chloroquine; Drug Resista | 1996 |
Chloroquine versus amodiaquine in the treatment of Plasmodium falciparum malaria in northeast India.
Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Female; H | 1995 |
Efficacy of oral and intravenous artesunate in male Tanzanian adults with Plasmodium falciparum malaria and in vitro susceptibility to artemisinin, chloroquine, and mefloquine.
Topics: Administration, Oral; Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Chloroqui | 1995 |
Sulfadoxine/pyrimethamine or chloroquine/clindamycin treatment of Gabonese school children infected with chloroquine resistant malaria.
Topics: Adolescent; Animals; Anti-Bacterial Agents; Antimalarials; Child; Child, Preschool; Chloroquine; Cli | 1995 |
A randomized trial of chloroquine, amodiaquine and pyrimethamine-sulphadoxine in Gambian children with uncomplicated malaria.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance | 1996 |
A note on present trend of chloroquine sensitivity of P. falciparum in Malkangiri District, Orissa.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Plasmodium | 1996 |
A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar in the treatment of uncomplicated malaria in children.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance | 1996 |
Comparability of treatment groups and risk factors for parasitemia at the first antenatal clinic visit in a study of malaria treatment and prevention in pregnancy in rural Malawi.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Female; Humans; Malaria, Falciparum; Malawi; Mefloqui | 1996 |
Malaria parasite infection during pregnancy and at delivery in mother, placenta, and newborn: efficacy of chloroquine and mefloquine in rural Malawi.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Female; Fetal Blood; Humans; Malaria, Falciparum; Mal | 1996 |
Objectives and methodology in a study of malaria treatment and prevention in pregnancy in rural Malawi: The Mangochi Malaria Research Project.
Topics: Antimalarials; Chloroquine; Female; Fetal Death; Follow-Up Studies; Humans; Infant, Low Birth Weight | 1996 |
Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antimalarials; Chloroquine; Drug Therapy, Combination; Fev | 1996 |
A comparative study of parenteral chloroquine, quinine and pyrimethamine-sulfadoxine in the treatment of Gambian children with complicated, non-cerebral malaria.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Data Interpretation, Statistical; Drug Combinat | 1996 |
In vivo efficacy of chloroquine, halofantrine, pyrimethamine-sulfadoxine and qinghaosu (artesunate) in the treatment of malaria in Calabar, Nigeria.
Topics: Adolescent; Antimalarials; Artemisinins; Artesunate; Child; Chloroquine; Drug Combinations; Drug Res | 1996 |
Chloroquine resistant falciparum malaria in Mutare District, eastern Zimbabwe.
Topics: Adolescent; Adult; Child; Chloroquine; Drug Resistance; Female; Humans; Incidence; Malaria, Falcipar | 1996 |
Response of childhood malaria to chloroquine and Fansidar in an area of intermediate chloroquine resistance in Côte d'Ivoire.
Topics: Animals; Antimalarials; Body Temperature; Child; Child, Preschool; Chloroquine; Cote d'Ivoire; Drug | 1996 |
A comparative study of the efficacies of chloroquine and a pyrimethamine-dapsone combination in clearing Plasmodium falciparum parasitaemia in school children in Tanzania.
Topics: Antimalarials; Child; Chloroquine; Dapsone; Drug Combinations; Female; Humans; Malaria, Falciparum; | 1996 |
Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine.
Topics: Alleles; Amodiaquine; Animals; Antimalarials; ATP-Binding Cassette Transporters; Child; Child, Presc | 1997 |
Malaria in a nonimmune population after extended chloroquine or primaquine prophylaxis.
Topics: Antimalarials; Chloroquine; Disease Susceptibility; Follow-Up Studies; Humans; Incidence; Indonesia; | 1997 |
Halofantrine and primaquine for radical cure of malaria in Irian Jaya, Indonesia.
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Follow-Up Studies; Humans; Indonesia; | 1997 |
Efficacy of artemether in severe falciparum malaria in African children.
Topics: Adolescent; Animals; Antimalarials; Artemether; Artemisinins; Child; Child, Preschool; Chloroquine; | 1996 |
Chloroquine-resistant Plasmodium falciparum among children in Calabar, south eastern Nigeria.
Topics: Administration, Oral; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; | 1997 |
In vivo resistance to chloroquine by Plasmodium vivax and Plasmodium falciparum at Nabire, Irian Jaya, Indonesia.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Hum | 1997 |
Chloroquine versus pyrimethamine/sulphadoxine in the treatment of uncomplicated P. falciparum malaria in northern Kenya.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resi | 1997 |
Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Antimalarials; Berberine; Child; Child, Preschool; C | 1997 |
The differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector.
Topics: Animals; Anopheles; Antimalarials; Carrier State; Chloroquine; Drug Combinations; Drug Resistance; F | 1998 |
Phase II trial in China of a new, rapidly-acting and effective oral antimalarial, CGP 56697, for the treatment of Plasmodium falciparum malaria.
Topics: Administration, Oral; Adolescent; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; A | 1997 |
Effect of chloroquine prophylaxis during pregnancy on maternal haematocrit.
Topics: Anemia; Antimalarials; Chloroquine; Female; Hematocrit; Humans; Malaria, Falciparum; Placenta; Pregn | 1998 |
Distinction of recrudescences from new infections by PCR-RFLP analysis in a comparative trial of CGP 56 697 and chloroquine in Tanzanian children.
Topics: Acute Disease; Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chil | 1998 |
Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged 1-5 years.
Topics: Acute Disease; Administration, Oral; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combin | 1998 |
Chloroquine in Africa: critical assessment and recommendations for monitoring and evaluating chloroquine therapy efficacy in sub-Saharan Africa.
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Monitoring; Drug Resistance; F | 1998 |
Response of uncomplicated falciparum malaria to oral chloroquine and quinine in Burundi highlands.
Topics: Administration, Oral; Adolescent; Age Factors; Antimalarials; Burundi; Child; Child, Preschool; Chlo | 1998 |
Response of falciparum malaria to different antimalarials in Myanmar.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Therapy, Combination; Humans; | 1999 |
Atovaquone-proguanil compared with chloroquine and chloroquine-sulfadoxine-pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines.
Topics: Antimalarials; Atovaquone; Chloroquine; Drug Therapy, Combination; Folic Acid Antagonists; Humans; M | 1999 |
Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in nonimmune Colombian soldiers.
Topics: Antimalarials; Chloroquine; Colombia; Double-Blind Method; Humans; Malaria; Malaria, Falciparum; Mal | 1999 |
Population structure of recrudescent Plasmodium falciparum isolates from western Uganda.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antigens, Protozoan; Antimalarials; Child; Chil | 1999 |
Short report: effects of pyronaridine on gametocytes in patients with acute uncomplicated falciparum malaria.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Hu | 1999 |
Molecular epidemiology of malaria in Yaounde, Cameroon V. analysis of the omega repetitive region of the plasmodium falciparum CG2 gene and chloroquine resistance.
Topics: Adolescent; Adult; Animals; Antimalarials; Cameroon; Child; Chloroquine; DNA Primers; DNA, Protozoan | 1999 |
Assessment of therapeutic response of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine in an area of low malaria transmission in Colombia.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Colombia; Disease T | 1999 |
Poor gametocytocidal activity of 45 mg primaquine in chloroquine-treated patients with acute, uncomplicated, Plasmodium falciparum malaria in Mumbai (Bombay): an issue of public-health importance.
Topics: Animals; Antimalarials; Chloroquine; Double-Blind Method; Drug Resistance; Drug Therapy, Combination | 1999 |
Monitoring efficacy of commonly used antimalarials by a 14-day in-vivo test in a new settler's camp in endemic zone at Cox's Bazar.
Topics: Adolescent; Adult; Antimalarials; Bangladesh; Child; Chloroquine; Drug Administration Schedule; Drug | 1998 |
Comparative efficacy of chloroquine plus chlorpheniramine alone and in a sequential combination with sulfadoxine-pyrimethamine, for the treatment of acute, uncomplicated, falciparum malaria in children.
Topics: Animals; Antimalarials; Antipruritics; Child; Child, Preschool; Chloroquine; Chlorpheniramine; Drug | 2000 |
A randomized, parallel-group study in Mumbai (Bombay), comparing chloroquine with chloroquine plus sulfadoxine-pyrimethamine in the treatment of adults with acute, uncomplicated, Plasmodium falciparum malaria.
Topics: Acute Disease; Adolescent; Adult; Aged; Antimalarials; Chloroquine; Cost of Illness; Cost-Benefit An | 2000 |
Teaching mothers to provide home treatment of malaria in Tigray, Ethiopia: a randomised trial.
Topics: Antimalarials; Child, Preschool; Chloroquine; Ethiopia; Female; Home Nursing; Humans; Infant; Malari | 2000 |
A randomized, double-blind, parallel-group, comparative safety, and efficacy trial of oral co-artemether versus oral chloroquine in the treatment of acute uncomplicated Plasmodium falciparum malaria in adults in India.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Antimalarials; Artemether, Lumefantrin | 2000 |
Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Malarone International Study Team.
Topics: Adolescent; Adult; Aged; Antimalarials; Anxiety; Atovaquone; Chloroquine; Dizziness; Double-Blind Me | 2000 |
Plasmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cohort Studies; Dru | 2001 |
Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.
Topics: Adolescent; Animals; Anopheles; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Ch | 2001 |
Rapid therapeutic response onset of a new pharmaceutical form of chloroquine phosphate 300 mg: effervescent tablets.
Topics: Adult; Antimalarials; Chloroquine; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Tablets; | 2001 |
Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda.
Topics: Adolescent; Adult; Age Factors; Animals; Antimalarials; Body Temperature; Child; Child, Preschool; C | 2000 |
Impact of prepackaging antimalarial drugs on cost to patients and compliance with treatment.
Topics: Acetaminophen; Adult; Antimalarials; Child; Chloroquine; Dosage Forms; Drug Costs; Drug Packaging; G | 2001 |
Atovaquone and proguani hydrochloride compared with chloroquine or pyrimethamine/sulfodaxine for treatment of acute Plasmodium falciparum malaria in Peru.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Atovaquone; Chloroquine; Drug Combinations; Drug Re | 2001 |
Ketotifen in treatment of uncomplicated falciparum malaria.
Topics: Adult; Antimalarials; Body Weight; Chloroquine; Drug Monitoring; Drug Therapy, Combination; Follow-U | 2000 |
The impact of insecticide-treated bednets on malaria and anaemia in pregnancy in Kassena-Nankana district, Ghana: a randomized controlled trial.
Topics: Analysis of Variance; Anemia; Bedding and Linens; Birth Weight; Chloroquine; Cluster Analysis; Endem | 2001 |
Efficacy of Sulphadoxine and Pyrimethamine, Doxycycline and their combination in the treatment of chloroquine resistant Falciparum Malaria.
Topics: Antimalarials; Chi-Square Distribution; Chloroquine; Doxycycline; Drug Resistance; Drug Therapy, Com | 2001 |
Gametocytaemia in Senegalese children with uncomplicated falciparum malaria treated with chloroquine, amodiaquine or sulfadoxine + pyrimethamine.
Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistan | 2001 |
Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.
Topics: Age Factors; Amodiaquine; Analysis of Variance; Antimalarials; Child; Child, Preschool; Chloroquine; | 2001 |
Therapeutic efficacy of chloroquine against uncomplicated, Plasmodium falciparum malaria in south-western Saudi Arabia.
Topics: Acute Disease; Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine | 2001 |
In vivo-in vitro model for the assessment of clinically relevant antimalarial cross-resistance.
Topics: Adult; Animals; Antimalarials; Artemisinins; Chloroquine; Cross Reactions; Drug Resistance; Drug The | 2001 |
A randomized comparison of chloroquine, amodiaquine and their combination with pyrimethamine-sulfadoxine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.
Topics: Acute Disease; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Therapy, Combi | 2002 |
Sulphadoxine/pyrimethamine: an appropriate first-line alternative for the treatment of uncomplicated falciparum malaria in Ghanaian children under 5 years of age.
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Follow-Up | 2002 |
Sulfadoxine-pyrimethamine monotherapy in Tanzanian children gives rapid parasite clearance but slow fever clearance that is improved by chloroquine in combination therapy.
Topics: Acetaminophen; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Dru | 2002 |
Pharmacokinetics of sequential and simultaneous treatment with the combination chloroquine and sulfadoxine-pyrimethamine in acute uncomplicated Plasmodium falciparum malaria in the Philippines.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Area Under Curve; Child; Chloroquine; Drug Administ | 2002 |
[Efficacy of radical treatment with halofantrine on the prevention of imported Plasmodium falciparum malaria].
Topics: Adult; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Male; Military Personnel; Phenanthre | 1992 |
Malaria in infants whose mothers received chemoprophylaxis: response to amodiaquine therapy.
Topics: Administration, Oral; Amodiaquine; Chloroquine; Drug Resistance; Female; Humans; Immunity, Maternall | 1992 |
Fansimef for prophylaxis of malaria: a double-blind randomized placebo controlled trial.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Double-Blind Method; Drug Combinations; Humans; Incid | 1992 |
Mefloquine-sulphadoxine-pyrimethamine (Fansimef, Roche) in the prophylaxis of Plasmodium falciparum malaria: a double-blind, comparative, placebo-controlled study.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Double-Blind Method; Drug Combinations; Humans; Malar | 1992 |
Comparison of artemether and chloroquine for severe malaria in Gambian children.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Child; Child, Preschool; Chloroquine; Gambia; Huma | 1992 |
A comparative study of the schizontocidal efficacy and safety of artemether versus chloroquine in uncomplicated malaria.
Topics: Adolescent; Adult; Antimalarials; Artemether; Artemisinins; Chloroquine; Female; Humans; Malaria, Fa | 1992 |
Clinical trials of mefloquine with tetracycline.
Topics: Acute Disease; Adolescent; Adult; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Com | 1992 |
Parasitological, clinical and haematological response of children with Plasmodium falciparum to 4-aminoquinolines and to pyrimethamine-sulfadoxine with quinine in western Kenya.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combinati | 1992 |
Norfloxacin is inferior to chloroquine for falciparum malaria in northwestern Zambia: a comparative clinical trial.
Topics: Adult; Chloroquine; Drug Resistance; Female; Follow-Up Studies; Humans; Malaria, Falciparum; Male; N | 1992 |
Evaluation of the relative efficacy of various antimalarial drugs in Nigerian children under five years of age suffering from acute uncomplicated falciparum malaria.
Topics: Acute Disease; Amodiaquine; Antimalarials; Child, Preschool; Chloroquine; Drug Administration Schedu | 1992 |
Development of the new antimalarial drug pyronaridine: a review.
Topics: Administration, Oral; Animals; Antimalarials; Cardiovascular System; Chloroquine; Dogs; Drug Evaluat | 1992 |
Sensitivity of falciparum malaria to chloroquine and amodiaquine in four districts of western Kenya (1985-1987).
Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Kenya | 1991 |
New trends in chloroquine efficacy in the treatment of malaria: chloroquine-resistant Plasmodium falciparum in Anambra and Benue States of Nigeria.
Topics: Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Infant; Malaria, Falciparum; Male; N | 1991 |
The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria.
Topics: Adult; Chloroquine; Double-Blind Method; Female; Follow-Up Studies; Humans; Malaria, Falciparum; Mal | 1991 |
Falciparum malaria fully cleared by amodiaquine, pyrimethamine-sulfadoxine and pyrimethamine-sulfalene in areas of chloroquine resistance in Dodoma, Tanzania.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance | 1991 |
Comparison of mefloquine, chloroquine plus pyrimethamine-sulfadoxine (Fansidar), and chloroquine as malarial prophylaxis in eastern Thailand.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Animals; Antimalarials; Cambodia; Chloroquine; Confid | 1991 |
1225 other studies available for chloroquine and Malaria, Falciparum
| Article | Year |
|---|---|
Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives.
Topics: Animals; Antimalarials; Cell Survival; Chloroquine; Drug Resistance; Humans; KB Cells; Limonins; Mal | 1997 |
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Artemisinins; Clone Cells; Drug Design; Inhibitory Con | 2003 |
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Topics: Adamantane; Animals; Antimalarials; Cell Line, Tumor; Drug Resistance; Half-Life; Malaria; Malaria, | 2005 |
In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum.
Topics: Animals; Antimalarials; Ketones; Malaria, Falciparum; Mice; Microsomes, Liver; Plasmodium falciparum | 2006 |
Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Chloroquine; Drug Synergism; HIV Protease Inhibitors; Humans; Malaria, Falci | 2007 |
In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.
Topics: Amodiaquine; Animals; Antimalarials; Azithromycin; DNA, Protozoan; Drug Resistance; Erythrocytes; Hu | 2007 |
In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Azithromycin; Clinical Trials, Phase II as Topic; | 2007 |
High-throughput Plasmodium falciparum growth assay for malaria drug discovery.
Topics: Animals; Biological Assay; Child, Preschool; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resi | 2007 |
Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives.
Topics: Administration, Oral; Alkanes; Amidines; Animals; Antimalarials; Female; Humans; Hydroxylation; Indi | 2007 |
2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization.
Topics: Animals; Antimalarials; Erythrocytes; Hemeproteins; Hemolysis; Humans; Malaria, Falciparum; Parasiti | 2007 |
Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes.
Topics: Animals; Antimalarials; Benzene Derivatives; Calorimetry, Differential Scanning; Chloroquine; Drug S | 2008 |
Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.
Topics: Animals; Antimalarials; Biological Transport, Active; Cell Membrane Permeability; Cysteine Proteinas | 2008 |
Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum.
Topics: Animals; Antimalarials; Drug Resistance, Multiple; Gene Dosage; Genes, MDR; Genes, Protozoan; HIV In | 2008 |
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors.
Topics: Animals; Antimalarials; Aotidae; Drug Resistance; Enzyme Inhibitors; Histone Deacetylase Inhibitors; | 2008 |
In vitro and in vivo properties of ellagic acid in malaria treatment.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Atovaquone; Chloroquine; Dose-Response Relationshi | 2009 |
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity.
Topics: Animals; Antimalarials; Astemizole; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclinica | 2009 |
Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.
Topics: Adenosine Triphosphatases; Amides; Animals; Antimalarials; Erythrocytes; HSP70 Heat-Shock Proteins; | 2009 |
Iodine-catalyzed one-pot synthesis and antimalarial activity evaluation of symmetrically and asymmetrically substituted 3,6-diphenyl[1,2,4,5]tetraoxanes.
Topics: Animals; Antimalarials; Artemisinins; Chemistry, Organic; Chemistry, Pharmaceutical; Chlorocebus aet | 2009 |
Dynamics of malaria drug resistance patterns in the Amazon basin region following changes in Peruvian national treatment policy for uncomplicated malaria.
Topics: Animals; Antimalarials; Drug Resistance; Genotype; Haplotypes; Health Policy; Humans; Malaria, Falci | 2009 |
Synthesis, antimalarial evaluation and molecular modeling studies of hydroxyethylpiperazines, potential aspartyl protease inhibitors, part 2.
Topics: Animals; Antimalarials; Aspartic Acid Endopeptidases; Cell Line; Erythrocytes; Ethanolamines; Humans | 2009 |
Synthesis, antimalarial activity and cytotoxicity of substituted 3,6-diphenyl-[1,2,4,5]tetraoxanes.
Topics: Animals; Antimalarials; Cell Line; Cell Survival; Chlorocebus aethiops; Crystallography, X-Ray; Mala | 2009 |
Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Disease Models, Animal; Erythrocytes; | 2009 |
Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes.
Topics: Aminoquinolines; Antimalarials; Cells, Cultured; Erythrocytes; Heme; Humans; Malaria, Falciparum; Mo | 2009 |
Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials.
Topics: Animals; Antimalarials; DNA, Protozoan; Drug Discovery; Drug Resistance; Erythrocytes; Flow Cytometr | 2009 |
Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Inhibitory Concentration 50; Malaria, Falcipar | 2009 |
Synthesis and antimalarial activity of new atovaquone derivatives.
Topics: Antimalarials; Atovaquone; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; | 2009 |
In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.
Topics: Animals; Antimalarials; Artemisinins; Ethanolamines; Fluorenes; Genotype; Humans; Lumefantrine; Mala | 2009 |
Antimalarial acridines: synthesis, in vitro activity against P. falciparum and interaction with hematin.
Topics: Aminoacridines; Antimalarials; Cell Line, Tumor; Cell Survival; Hemin; Humans; Inhibitory Concentrat | 2009 |
Synthesis and structure-activity relationships of cassiarin A as potential antimalarials with vasorelaxant activity.
Topics: Animals; Antimalarials; Binding, Competitive; Cell Adhesion Molecules; Cell Separation; Endothelial | 2009 |
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Topics: Animals; Antimalarials; Heterocyclic Compounds, 1-Ring; Malaria, Falciparum; Mice; Molecular Conform | 2010 |
Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism.
Topics: Antimalarials; Artemisinins; Artesunate; Cambodia; Drug Resistance, Bacterial; Erythrocytes; Flow Cy | 2010 |
Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids.
Topics: Antimalarials; Chalcone; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Isatin; La | 2010 |
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Foli | 2010 |
New antimalarials with a triterpenic scaffold from Momordica balsamina.
Topics: Antimalarials; Cell Line, Tumor; Cell Survival; Humans; Malaria, Falciparum; Models, Molecular; Momo | 2010 |
New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.
Topics: Animals; Antimalarials; Cell Survival; Chlorocebus aethiops; Farnesyltranstransferase; Humans; Malar | 2010 |
Anti-HIV and antiplasmodial activity of original flavonoid derivatives.
Topics: Anti-HIV Agents; Antimalarials; Cell Line; Cell Survival; Flavonoids; HIV; HIV Infections; Humans; M | 2010 |
2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.
Topics: Alkynes; Antimalarials; Binding Sites; Cell Line, Tumor; Computer Simulation; Erythrocytes; Fatty Ac | 2010 |
In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalcones.
Topics: Aminoquinolines; Antimalarials; Chalcones; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum | 2011 |
Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina.
Topics: Alkaloids; Animals; Antimalarials; Cell Line; Humans; Isoxazoles; Malaria, Falciparum; Oxepins; Plas | 2011 |
Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.
Topics: Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Indoles; Malaria, Fa | 2011 |
Synthesis and antimalarial activity of new heterocyclic hybrids based on chloroquine and thiazolidinone scaffolds.
Topics: Animals; Antimalarials; Cell Line; Cell Survival; Chloroquine; Drug Resistance, Multiple; Hep G2 Cel | 2011 |
The anti-malarial activity of bivalent imidazolium salts.
Topics: Animals; Antimalarials; Disease Models, Animal; Erythrocytes; Imidazoles; Magnetic Resonance Spectro | 2011 |
Synthesis and antimalarial evaluation of novel isocryptolepine derivatives.
Topics: 3T3 Cells; Animals; Antimalarials; Chloroquine; Humans; Indole Alkaloids; Malaria, Falciparum; Mice; | 2011 |
Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents.
Topics: Animals; Antimalarials; Benzimidazoles; Cell Line; Humans; Inhibitory Concentration 50; Malaria, Fal | 2011 |
Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.
Topics: Animals; Antimalarials; Biological Availability; Caco-2 Cells; Humans; Imidazoles; Malaria, Falcipar | 2012 |
Coumarin-trioxane hybrids: synthesis and evaluation as a new class of antimalarial scaffolds.
Topics: Aldehydes; Animals; Antimalarials; Benzenesulfonates; Coumarins; Erythrocytes; Heterocyclic Compound | 2012 |
Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum.
Topics: Animals; Antimalarials; Cell Survival; Chalcone; Chlorocebus aethiops; Chloroquine; Drug Resistance; | 2012 |
Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline.
Topics: Aminoquinolines; Antimalarials; Cell Line; Cell Survival; Humans; Malaria, Falciparum; Plasmodium fa | 2012 |
Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids.
Topics: Animals; Antimalarials; Cell Survival; CHO Cells; Cricetinae; Inhibitory Concentration 50; Malaria, | 2013 |
Addition of thiols to o-quinone methide: new 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7).
Topics: Antimalarials; Cells, Cultured; Flow Cytometry; Humans; Indolequinones; Malaria, Falciparum; Molecul | 2013 |
Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives.
Topics: 2-Naphthylamine; Animals; Antimalarials; Area Under Curve; Dihydroorotate Dehydrogenase; Drug Discov | 2013 |
3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.
Topics: Animals; Antimalarials; Drug Resistance; Hep G2 Cells; Humans; Liver; Malaria; Malaria, Falciparum; | 2013 |
Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.
Topics: Antimalarials; Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Dimerization; Humans; Malaria, Fa | 2013 |
Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation.
Topics: Antimalarials; beta-Lactams; Chloroquine; Humans; Malaria, Falciparum; Oxamic Acid; Plasmodium falci | 2014 |
Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents.
Topics: Antiprotozoal Agents; Drug Design; Entamoeba histolytica; Entamoebiasis; Humans; Hydrazones; Malaria | 2014 |
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
Topics: Animals; Antimalarials; Biological Availability; Drug Design; Drug Resistance; Drug Stability; Gene | 2014 |
Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.
Topics: Animals; Antimalarials; Benzimidazoles; Biological Availability; Cell Line, Tumor; Cell Survival; Hi | 2014 |
Preparation and antimalarial activity of a novel class of carbohydrate-derived, fused thiochromans.
Topics: Antimalarials; Carbohydrates; Cell Proliferation; Cells, Cultured; Chromans; Glycosides; Humans; Mal | 2014 |
Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials.
Topics: Antimalarials; Antimicrobial Cationic Peptides; Cysteine Endopeptidases; HEK293 Cells; Humans; Malar | 2014 |
Synthesis and in vitro evaluation of novel 8-aminoquinoline-pyrazolopyrimidine hybrids as potent antimalarial agents.
Topics: Aminoquinolines; Antimalarials; Humans; Malaria, Falciparum; Molecular Docking Simulation; Parasitic | 2015 |
Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives.
Topics: Animals; Antimalarials; Hep G2 Cells; Humans; Malaria; Malaria, Falciparum; Male; Mice; Naphthyridin | 2015 |
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Topics: Aminoquinolines; Animals; Antimalarials; Brain; Cell Line; Dimerization; Hemeproteins; Humans; Malar | 2015 |
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.
Topics: Alkylation; Antimalarials; Humans; Life Cycle Stages; Malaria, Falciparum; Plasmodium falciparum; Po | 2015 |
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.
Topics: Amides; Animals; Antimalarials; Benzamides; Benzimidazoles; Cell Proliferation; Cells, Cultured; Dru | 2015 |
Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Topics: Animals; Antimalarials; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Fem | 2015 |
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
Topics: Aminoquinolines; Animals; Antimalarials; Benzene Derivatives; Humans; Malaria; Malaria, Falciparum; | 2015 |
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.
Topics: Animals; Antimalarials; Ether-A-Go-Go Potassium Channels; Humans; Liver; Malaria; Malaria, Falciparu | 2015 |
Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.
Topics: Alkyl and Aryl Transferases; Animals; Antiparasitic Agents; Cell Line; Enzyme Inhibitors; Humans; Im | 2016 |
Novel morpholinoquinoline nucleus clubbed with pyrazoline scaffolds: Synthesis, antibacterial, antitubercular and antimalarial activities.
Topics: Anti-Infective Agents; Antimalarials; Antitubercular Agents; Bacteria; Bacterial Infections; Fungi; | 2016 |
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Dose-Response Relation | 2016 |
Selective anti-malarial minor groove binders.
Topics: Antimalarials; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Malaria, Falciparum; Molecula | 2016 |
Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.
Topics: Animals; Antimalarials; Humans; Malaria; Malaria, Falciparum; Mice, SCID; Parasitemia; Plasmodium be | 2016 |
Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.
Topics: Aniline Compounds; Animals; Antiprotozoal Agents; Benzimidazoles; Cell Line; Humans; Malaria, Falcip | 2016 |
New hydrazine and hydrazide quinoxaline 1,4-di-N-oxide derivatives: In silico ADMET, antiplasmodial and antileishmanial activity.
Topics: Antiprotozoal Agents; Humans; Hydrazines; Leishmania infantum; Leishmaniasis, Visceral; Malaria, Fal | 2017 |
Synthesis and evaluation of anti-plasmodial and cytotoxic activities of epoxyazadiradione derivatives.
Topics: Animals; Antimalarials; Antineoplastic Agents; Azadirachta; Cell Line, Tumor; Cell Proliferation; Hu | 2017 |
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.
Topics: Amides; Animals; Antimalarials; Boron Compounds; Dogs; Female; Humans; Malaria; Malaria, Falciparum; | 2017 |
The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.
Topics: Antimalarials; Antineoplastic Agents; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Dose-Resp | 2018 |
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analog
Topics: Antimalarials; Dose-Response Relationship, Drug; Enzyme Inhibitors; Furans; Life Cycle Stages; Malar | 2018 |
Designing novel inhibitors against falcipain-2 of Plasmodium falciparum.
Topics: Animals; Antimalarials; Coumarins; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Drug D | 2018 |
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Female; Humans; Imidazoles; Inhibitory Con | 2018 |
MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.
Topics: Aldose-Ketose Isomerases; Animals; Antimalarials; Female; Fosfomycin; Malaria, Falciparum; Mice; Pla | 2018 |
One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
Topics: Acetylation; Antimalarials; Hep G2 Cells; Histone Deacetylase Inhibitors; Histones; Humans; Malaria, | 2018 |
Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites.
Topics: Antimalarials; Benzimidazoles; Dose-Response Relationship, Drug; Hemeproteins; Malaria, Falciparum; | 2018 |
Improvement of Asparagine Ethylenediamines as Anti-malarial
Topics: Antimalarials; Asparagine; Drug Resistance; Ethylenediamines; Humans; Malaria, Falciparum; Mutation; | 2019 |
Green synthesis, biological evaluation, molecular docking studies and 3D-QSAR analysis of novel phenylalanine linked quinazoline-4(3H)-one-sulphonamide hybrid entities distorting the malarial reductase activity in folate pathway.
Topics: Antimalarials; Humans; Malaria, Falciparum; Molecular Docking Simulation; Molecular Structure; Pheny | 2019 |
Synthesis and efficacy of pyrvinium-inspired analogs against tuberculosis and malaria pathogens.
Topics: Antimalarials; Antitubercular Agents; Dose-Response Relationship, Drug; Malaria, Falciparum; Microbi | 2020 |
Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents.
Topics: Antimalarials; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Malaria, Falciparu | 2020 |
β-Hydroxy- and β-Aminophosphonate Acyclonucleosides as Potent Inhibitors of
Topics: Animals; Antimalarials; Female; Humans; K562 Cells; Malaria, Falciparum; Mice; Nucleosides; Organoph | 2020 |
Discovery of fast-acting dual-stage antimalarial agents by profiling pyridylvinylquinoline chemical space via copper catalyzed azide-alkyne cycloadditions.
Topics: Antimalarials; Azides; Copper; Cycloaddition Reaction; Hep G2 Cells; Humans; Life Cycle Stages; Mala | 2021 |
Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors.
Topics: Antimalarials; Chloroquine; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Hep G2 Cel | 2021 |
Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion.
Topics: Animals; Antimalarials; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Erythro | 2021 |
Novel molecule combinations and corresponding hybrids targeting artemisinin-resistant Plasmodium falciparum parasites.
Topics: Antimalarials; Artemisinins; Atovaquone; Dose-Response Relationship, Drug; Drug Resistance; Humans; | 2021 |
Discovery and development of 2-aminobenzimidazoles as potent antimalarials.
Topics: Antimalarials; Benzimidazoles; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Human | 2021 |
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.
Topics: Administration, Oral; Animals; Antimalarials; Humans; Malaria, Falciparum; Mice; Molecular Structure | 2021 |
Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents.
Topics: Antimalarials; Chloroquine; Harmine; Heme; Humans; Malaria, Falciparum; Plasmodium falciparum | 2022 |
Drug susceptibility of
Topics: Antimalarials; Chloroquine; Genotype; Humans; Longitudinal Studies; Lumefantrine; Malaria, Falciparu | 2021 |
The return of chloroquine-sensitive Plasmodium falciparum parasites in Jazan region, southwestern Saudi Arabia over a decade after the adoption of artemisinin-based combination therapy: analysis of genetic mutations in the pfcrt gene.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Mut | 2021 |
The Rare, the Best: Spread of Antimalarial-Resistant Plasmodium falciparum Parasites by
Topics: Alleles; Animals; Anopheles; Antimalarials; Cameroon; Chloroquine; Drug Resistance; Genetic Variatio | 2021 |
Topics: Antimalarials; Chloroquine; GTP Phosphohydrolases; Humans; Malaria, Falciparum; Plasmodium falciparu | 2022 |
Chloroquine-resistant Plasmodium falciparum in Pakistan.
Topics: Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Pakistan; Plasmodium falciparum | 2021 |
Frequency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malaria.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Brazil; Case-Control Studies; Chlor | 2022 |
FIT-PNAs as RNA-Sensing Probes for Drug-Resistant
Topics: Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Peptide Nucleic Acids; Plasmodium falciparu | 2022 |
Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.
Topics: Alleles; Animals; Antimalarials; Artemisinins; Chloroquine; Computer Simulation; Drug Resistance, Mu | 2022 |
Chloroquine-susceptible and -resistant Plasmodium falciparum strains survive high chloroquine concentrations by becoming dormant but are eliminated by prolonged exposure.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum | 2022 |
Targeted Amplicon Deep Sequencing for Monitoring Antimalarial Resistance Markers in Western Kenya.
Topics: Antimalarials; Child; Chloroquine; Codon; Drug Combinations; Drug Resistance; Folic Acid Antagonists | 2022 |
Iloneoside, an antimalarial pregnane glycoside isolated from Gongronema latifolium leaf, potentiates the activity of chloroquine against multidrug resistant Plasmodium falciparum.
Topics: Antimalarials; Apocynaceae; Chloroquine; Drug Resistance; Folic Acid Antagonists; Glycosides; Malari | 2022 |
Evaluations of candidate markers of dihydroartemisinin-piperaquine resistance in Plasmodium falciparum isolates from the China-Myanmar, Thailand-Myanmar, and Thailand-Cambodia borders.
Topics: Antimalarials; Artemisinins; Biomarkers; Cambodia; Chloroquine; Drug Resistance; Humans; Malaria, Fa | 2022 |
A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility.
Topics: Animals; Antimalarials; Chloroquine; DNA Copy Number Variations; Drug Resistance; Exonucleases; Mala | 2022 |
Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers.
Topics: Amodiaquine; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artesunate; Child | 2022 |
Molecular Markers for Sulfadoxine/Pyrimethamine and Chloroquine Resistance in Plasmodium falciparum in Thailand.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Plasmod | 2022 |
Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Lumefantrine; Malar | 2022 |
Decoding the Role of Melatonin Structure on
Topics: Animals; Chloroquine; Humans; Indoles; Malaria; Malaria, Falciparum; Melatonin; Parasitemia; Parasit | 2022 |
Genetic Diversity of Plasmodium falciparum and Distribution of Antimalarial Drug Resistance Mutations in Symptomatic and Asymptomatic Infections.
Topics: Antimalarials; Asymptomatic Infections; Chloroquine; Drug Resistance; Folic Acid Antagonists; Genoty | 2022 |
The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Membrane Transport Proteins; Oligo | 2022 |
[Pcr-rflp genotyping of
Topics: Amodiaquine; Artesunate; Child; Chloroquine; Drug Resistance; Genotype; Humans; Madagascar; Malaria, | 2022 |
Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials.
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Gabon; Humans; Malaria, Falciparum; P | 2022 |
Molecular Epidemiology of Drug Resistance Genes in Plasmodium falciparum Isolates Imported from Nigeria between 2016 and 2020: Continued Emergence of Fully Resistant
Topics: Alleles; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Molecular Epidemi | 2022 |
Evaluation of ferrocenyl-containing γ-hydroxy-γ-lactam-derived tetramates as potential antiplasmodials.
Topics: Antimalarials; Chloroquine; Humans; Lactams; Malaria, Falciparum; Metallocenes; Plasmodium falciparu | 2022 |
Drug resistance and population structure of Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Mal | 2022 |
High prevalence of Pfcrt 76T and Pfmdr1 N86 genotypes in malaria infected patients attending health facilities in East Shewa zone, Oromia Regional State, Ethiopia.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Chloroquine; Drug Resistance; | 2022 |
Genome-wide functional screening of drug-resistance genes in Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Plasmodium fal | 2022 |
The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures.
Topics: Amyloid beta-Peptides; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Malaria, F | 2022 |
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Heme; Hemoglobins; Humans; Malar | 2022 |
Molecular surveillance for anti-malarial drug resistance and genetic diversity of Plasmodium falciparum after chloroquine and sulfadoxine-pyrimethamine withdrawal in Quibdo, Colombia, 2018.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Chloroquine; Codon; Colombia; | 2022 |
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Chloroquine; Ghana; Humans; Lu | 2022 |
A Novel
Topics: Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum; Primaquine | 2022 |
Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues.
Topics: Acetylene; Alkynes; Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Fa | 2022 |
Anti-malarial investigation of Acorus calamus, Dichapetalum gelonioides, and Leucas aspera on Plasmodium falciparum strains.
Topics: Acorus; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum | 2022 |
Anti-malarial investigation of Acorus calamus, Dichapetalum gelonioides, and Leucas aspera on Plasmodium falciparum strains.
Topics: Acorus; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum | 2022 |
Anti-malarial investigation of Acorus calamus, Dichapetalum gelonioides, and Leucas aspera on Plasmodium falciparum strains.
Topics: Acorus; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum | 2022 |
Anti-malarial investigation of Acorus calamus, Dichapetalum gelonioides, and Leucas aspera on Plasmodium falciparum strains.
Topics: Acorus; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum | 2022 |
Development of Mitochondria Targeting AIE-Active Cyclometalated Iridium Complexes as Potent Antimalarial Agents.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Multiple; Humans; Iridium; Malaria, Falci | 2023 |
Development of Mitochondria Targeting AIE-Active Cyclometalated Iridium Complexes as Potent Antimalarial Agents.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Multiple; Humans; Iridium; Malaria, Falci | 2023 |
Development of Mitochondria Targeting AIE-Active Cyclometalated Iridium Complexes as Potent Antimalarial Agents.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Multiple; Humans; Iridium; Malaria, Falci | 2023 |
Development of Mitochondria Targeting AIE-Active Cyclometalated Iridium Complexes as Potent Antimalarial Agents.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Multiple; Humans; Iridium; Malaria, Falci | 2023 |
Targeting malaria parasites with novel derivatives of azithromycin.
Topics: Animals; Antimalarials; Azithromycin; Chloroquine; Humans; Malaria; Malaria, Falciparum; Parasites; | 2022 |
Blood-stage antiplasmodial activity and oocyst formation-blockage of metallo copper-cinchonine complex.
Topics: Animals; Antimalarials; Chloroquine; Copper; Malaria, Falciparum; Malaria, Vivax; Mice; Oocysts; Par | 2022 |
Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Parasites; Plasmo | 2022 |
Molecular surveillance of anti-malarial drug resistance genes in Plasmodium falciparum isolates in Odisha, India.
Topics: Antimalarials; Artesunate; Chloroquine; Drug Combinations; Drug Resistance; Humans; India; Malaria, | 2022 |
Steroids from Diplazium esculentum: Antiplasmodial activity and molecular docking studies to investigate their binding modes.
Topics: Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Molecular Docking Simulation; Plant Extract | 2022 |
Antiplasmodial activity, structure-activity relationship and studies on the action of novel benzimidazole derivatives.
Topics: Antimalarials; Benzimidazoles; Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum; Stru | 2023 |
A Plasmodium falciparum RING Finger E3 Ubiquitin Ligase Modifies the Roles of PfMDR1 and PfCRT in Parasite Drug Responses.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transport Protein | 2023 |
IFNγ, TNFα polymorphisms and IFNγ serum levels are associated with the clearance of drug-resistant P. falciparum in Malian children.
Topics: Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Membrane T | 2023 |
Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches.
Topics: Antimalarials; Bayes Theorem; Chloroquine; Humans; Malaria, Falciparum; Molecular Docking Simulation | 2023 |
Integrating Pharmacokinetic-Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Humans; Malaria, Falciparum; Mice; Plas | 2023 |
Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana.
Topics: Antimalarials; Chloroquine; Ghana; Humans; Malaria; Malaria, Falciparum; Plasmodium falciparum; Plas | 2023 |
Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1.
Topics: Amino Acid Transport Systems; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium | 2023 |
Monitoring antimalarial drug-resistance markers in Somalia.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Plasmodium falciparum; Somalia | 2023 |
Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Dogs; Malaria; Malaria, Falciparum; Plasmodium fa | 2023 |
Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Chloroquine; Drug Resistance; | 2023 |
PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Kinetics; Malaria, Falciparum; Mutation; Plasmo | 2023 |
Antiplasmodial Activity Evaluation of a Bestatin-Related Aminopeptidase Inhibitor, Phebestin.
Topics: Aminopeptidases; Animals; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Mice; Pa | 2023 |
Quantification of Plasmodium falciparum HRP-2 as an alternative method to [
Topics: Animals; Antimalarials; Chloroquine; Hypoxanthine; Malaria, Falciparum; Parasites; Plasmodium falcip | 2023 |
Development of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation.
Topics: Antimalarials; Chloroquine; Endothelial Cells; Humans; Lab-On-A-Chip Devices; Malaria; Malaria, Falc | 2023 |
pH-dependence of the Plasmodium falciparum chloroquine resistance transporter is linked to the transport cycle.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Hydrogen-Ion Concentration; Malaria, Falciparum | 2023 |
Rebound of multiple infections and prevalence of anti-malarial resistance associated markers following malaria upsurges in Dielmo village, Senegal, West Africa.
Topics: Africa, Western; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Membrane Transpor | 2023 |
Geo-environmental factors and the effectiveness of mulberry leaf extract in managing malaria.
Topics: Chloroquine; Malaria; Malaria, Falciparum; Methanol; Morus; Plant Extracts | 2023 |
Structure-Activity Relationships and Antiplasmodial Potencies of Novel 3,4-Disubstituted 1,2,5-Oxadiazoles.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Plasmodium falciparum; Structure-A | 2023 |
Rapid profiling of Plasmodium parasites from genome sequences to assist malaria control.
Topics: Animals; Antimalarials; Chloroquine; Coinfection; Drug Resistance; Humans; Malaria; Malaria, Falcipa | 2023 |
Genomic analysis of Plasmodium vivax describes patterns of connectivity and putative drivers of adaptation in Ethiopia.
Topics: Antimalarials; Chloroquine; Drug Resistance; Ethiopia; Genomics; Humans; Malaria, Falciparum; Malari | 2023 |
Prevalence of Molecular Markers of Antimalarial Drug Resistance across Altitudinal Transmission Zones in Highland Western Uganda.
Topics: Antimalarials; Chloroquine; Drug Resistance; Genetic Markers; Geography; Humans; Malaria, Falciparum | 2019 |
Adherence to antimalarial drug policy among doctors in Delta State, Nigeria: implications for malaria control.
Topics: Adult; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artesunate; Chloroquine | 2019 |
Prevalence of Plasmodium falciparum Pfcrt and Pfmdr1 alleles in settings with different levels of Plasmodium vivax co-endemicity in Ethiopia.
Topics: Adolescent; Adult; Alleles; Antimalarials; Artemether, Lumefantrine Drug Combination; Child; Chloroq | 2019 |
Characterization of drug resistance and genetic diversity of Plasmodium falciparum parasites from Tripura, Northeast India.
Topics: Antimalarials; Chloroquine; Drug Resistance; Genetic Variation; India; Malaria, Falciparum; Mutation | 2019 |
DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon.
Topics: Adolescent; Adult; Biological Specimen Banks; Body Temperature; Child; Child, Preschool; Chloroquine | 2019 |
The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo.
Topics: Adolescent; Adult; Alcohol Dehydrogenase; Antimalarials; Chloroquine; Cross-Sectional Studies; Democ | 2019 |
A multilamellar nanoliposome stabilized by interlayer hydrogen bonds increases antimalarial drug efficacy.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Cross-Linking Reagents; Drug Delivery Systems; Hy | 2019 |
En-route to the 'elimination' of genotypic chloroquine resistance in Western and Southern Zambia, 14 years after chloroquine withdrawal.
Topics: Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Cross-Sectional Studies; Dried Blood | 2019 |
Multiple-targets Directed Screening of Flavonoid Compounds from
Topics: Antimalarials; Chloroquine; Citrus; Computer Simulation; Density Functional Theory; Drug Resistance; | 2021 |
Antimalarial Drug Resistance Profiling of Plasmodium falciparum Infections in Ghana Using Molecular Inversion Probes and Next-Generation Sequencing.
Topics: Adolescent; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Combinations; Dr | 2020 |
Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in Southeast of Tanzania.
Topics: Antimalarials; Artemisinins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; D | 2020 |
Epidemiology of malaria and chloroquine resistance in Mizoram, northeastern India, a malaria-endemic region bordering Myanmar.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Child; Child, Preschool; Chloroquine; Dru | 2020 |
A multicomponent reaction to design antimalarial pyridyl-indole derivatives: Synthesis, biological activities and molecular docking.
Topics: Antimalarials; Chloroquine; Combinatorial Chemistry Techniques; Drug Design; Drug Resistance; Humans | 2020 |
Molecular surveillance of anti-malarial drug resistance in Democratic Republic of Congo: high variability of chloroquinoresistance and lack of amodiaquinoresistance.
Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Democrati | 2020 |
Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?
Topics: Antimalarials; Chloroquine; Drug Resistance; Evolution, Molecular; Humans; Malaria, Falciparum; Memb | 2020 |
Nationwide Monitoring for Plasmodium falciparum Drug-Resistance Alleles to Chloroquine, Sulfadoxine, and Pyrimethamine, Haiti, 2016-2017.
Topics: Alleles; Antimalarials; Chloroquine; Drug Resistance; Haiti; Humans; Malaria, Falciparum; Mutation; | 2020 |
Effects of combined drug treatments on Plasmodium falciparum: In vitro assays with doxycycline, ivermectin and efflux pump inhibitors.
Topics: Antimalarials; Chloroquine; Doxycycline; Drug Resistance; Drug Therapy, Combination; Humans; Ivermec | 2020 |
Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate
Topics: Africa; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Hydrolases; Malaria, Falc | 2020 |
Is Coronavirus Disease 2019 (COVID-19) seen less in countries more exposed to Malaria?
Topics: Africa South of the Sahara; Anti-Inflammatory Agents; Antigen Presentation; Antimalarials; Antiviral | 2020 |
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.
Topics: Antimalarials; Chloroquine; Democratic Republic of the Congo; Drug Combinations; Drug Resistance; Ge | 2020 |
Unsymmetrical Bisquinolines with High Potency against
Topics: Antimalarials; Chloroquine; Erythrocytes; Humans; Inhibitory Concentration 50; Malaria, Falciparum; | 2020 |
Rab7 of Plasmodium falciparum is involved in its retromer complex assembly near the digestive vacuole.
Topics: Antimalarials; Chloroquine; Humans; Magnesium; Malaria, Falciparum; Models, Molecular; Plasmodium fa | 2020 |
Ex-vivo Sensitivity of Plasmodium falciparum to Common Anti-malarial Drugs: The Case of Kéniéroba, a Malaria Endemic Village in Mali.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Res | 2020 |
Altered Drug Transport by
Topics: Antimalarials; Biological Transport; Cell Culture Techniques; Chloroquine; Drug Resistance; Humans; | 2020 |
Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Chloroquine; Drug Resistance; F | 2021 |
Characterization of putative drug resistant biomarkers in Plasmodium falciparum isolated from Ghanaian blood donors.
Topics: Adolescent; Adult; Alleles; Antimalarials; Asymptomatic Diseases; Biomarkers; Blood Donors; Chloroqu | 2020 |
The natural function of the malaria parasite's chloroquine resistance transporter.
Topics: Animals; Antimalarials; Biological Transport, Active; Chloroquine; Drug Resistance; Female; Host-Par | 2020 |
Establishing a National Molecular Surveillance Program for the Detection of
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Dru | 2020 |
Plasmodium falciparum replication factor C subunit 1 is involved in genotoxic stress response.
Topics: Antimalarials; Artesunate; Cell Death; Chloroquine; DNA Damage; DNA Repair; DNA Replication; DNA, Pr | 2021 |
Persistence of Markers of Chloroquine Resistance in
Topics: Antimalarials; Bangladesh; Chloroquine; Drug Resistance; Genetic Markers; Genotype; Humans; Malaria, | 2021 |
Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase.
Topics: Antimalarials; Artemisinins; Chloroquine; DNA Repair; Enzyme Inhibitors; Humans; Malaria, Falciparum | 2020 |
Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana.
Topics: Amodiaquine; Antimalarials; Biomarkers, Pharmacological; Carrier State; Child, Preschool; Chloroquin | 2020 |
Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment.
Topics: Antimalarials; Child; Chloroquine; Drug Resistance; Gabon; Humans; Malaria; Malaria, Falciparum; Pla | 2021 |
Epitope-specific IgG pools identify PfCRT monomer and homodimer polypeptides that are differentially phosphorylated at Ser
Topics: Antimalarials; Chloroquine; Dimerization; Epitopes; HEK293 Cells; Humans; Immunoglobulin G; Malaria, | 2021 |
Longitudinal ex vivo and molecular trends of chloroquine and piperaquine activity against Plasmodium falciparum and P. vivax before and after introduction of artemisinin-based combination therapy in Papua, Indonesia.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Indonesia; Malaria, Falciparum; P | 2021 |
Selection of
Topics: Alleles; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Child, Preschool; Chloroqui | 2021 |
Cross-resistance of the chloroquine-derivative AQ-13 with amodiaquine in Cambodian Plasmodium falciparum isolates.
Topics: Amodiaquine; Antimalarials; Asian People; Chloroquine; Drug Combinations; Drug Resistance; Humans; M | 2021 |
Decreased prevalence of the Plasmodium falciparum Pfcrt K76T and Pfmdr1 and N86Y mutations post-chloroquine treatment withdrawal in Katete District, Eastern Zambia.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Malaria, Falciparum; Male; Memb | 2021 |
Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation.
Topics: Aminoquinolines; Antimalarials; Chalcone; Chloroquine; Drug Resistance; Ferrous Compounds; HeLa Cell | 2017 |
Reemergence of chloroquine-sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern Cameroon.
Topics: Antimalarials; Cameroon; Child, Preschool; Chloroquine; Drug Resistance; Female; Genotype; Humans; I | 2017 |
Genetic polymorphisms in Plasmodium falciparum chloroquine resistance genes, pfcrt and pfmdr1, in North Sulawesi, Indonesia.
Topics: Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Drug Resistance, Multiple; Gene Frequen | 2017 |
Antibody Responses to
Topics: Adaptive Immunity; Antibodies, Protozoan; Antimalarials; Artemisinins; Artesunate; Chloroquine; Coho | 2017 |
Correlation between in vitro and in vivo antimalarial activity of compounds using CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and CQ-resistant strain of P. yoelii.
Topics: Animals; Antimalarials; Chloroquine; Malaria, Falciparum; Mice; Parasitemia; Plasmodium falciparum | 2017 |
Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Indonesia; Malaria, Falciparum; Malaria, Vivax; | 2017 |
Pooled-DNA sequencing identifies genomic regions of selection in Nigerian isolates of Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Gene Frequency; Genetic Variation; H | 2017 |
Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Female; Humans; Malaria, Falciparum; Metabolic | 2017 |
Progressive increase in point mutations associates chloroquine resistance: Even after withdrawal of chloroquine use in India.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Coinfection; Drug Resi | 2017 |
Return of chloroquine sensitivity to Africa? Surveillance of African Plasmodium falciparum chloroquine resistance through malaria imported to China.
Topics: Africa; China; Chloroquine; Communicable Diseases, Imported; Drug Resistance; Genotype; Humans; Mala | 2017 |
HIV-malaria interactions in North-East India: A prospective cohort study.
Topics: Adolescent; Adult; Antimalarials; Child, Preschool; Chloroquine; Coinfection; Drug Resistance; Femal | 2017 |
In vivo study of Plasmodium falciparum chloroquine susceptibility in three departments of Haiti.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Femal | 2017 |
Molecular analysis demonstrates high prevalence of chloroquine resistance but no evidence of artemisinin resistance in Plasmodium falciparum in the Chittagong Hill Tracts of Bangladesh.
Topics: Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; Bangladesh; Chloroquine; Drug Resist | 2017 |
Platinum(ii)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function.
Topics: Animals; Antimalarials; Cell Line; Cell Line, Tumor; Chloroquine; Coordination Complexes; Dogs; Eryt | 2017 |
Sustained
Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Therapy, Combination; E | 2017 |
Plasmodium falciparum uses vitamin E to avoid oxidative stress.
Topics: Animals; Antimalarials; Benzofurans; Chloroquine; Erythrocytes; Humans; Malaria, Falciparum; Microsc | 2017 |
Haiti's Commitment to Malaria Elimination: Progress in the Face of Challenges, 2010-2016.
Topics: Antimalarials; Chloroquine; Cholera; Disasters; Disease Eradication; Disease Outbreaks; Earthquakes; | 2017 |
Molecular surveillance of chloroquine drug resistance markers (Pfcrt and Pfmdr1) among imported Plasmodium falciparum malaria in Qatar.
Topics: Adolescent; Adult; Antimalarials; Blood; Chloroquine; Communicable Diseases, Imported; DNA, Protozoa | 2018 |
Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; | 2017 |
In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine.
Topics: Alkaloids; Antimalarials; Chloroquine; Ethanolamines; Fluorenes; Gametogenesis; Ghana; Humans; Indol | 2017 |
Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action.
Topics: Antigens, Protozoan; Antimalarials; Chloroquine; Drug Delivery Systems; Drug Resistance; Glutathione | 2018 |
Topics: Anti-Bacterial Agents; Antimalarials; Artemether; Artemisinins; Atovaquone; Azithromycin; Chloroquin | 2017 |
Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity.
Topics: Animals; Antibodies, Protozoan; Antibody Formation; Antimalarials; Chloroquine; Humans; Malaria Vacc | 2018 |
Chloroquine diphosphate bearing dextran nanoparticles augmented drug delivery and overwhelmed drug resistance in Plasmodium falciparum parasites.
Topics: Chloroquine; Dextrans; Drug Delivery Systems; Drug Resistance; Humans; Malaria, Falciparum; Nanopart | 2018 |
Longitudinal surveillance of drug resistance in Plasmodium falciparum isolates from the China-Myanmar border reveals persistent circulation of multidrug resistant parasites.
Topics: Antimalarials; Artemisinins; China; Chloroquine; Drug Resistance, Multiple; Epidemiological Monitori | 2018 |
Spatio-temporal distribution of PfMDR1 polymorphism among uncomplicated Plasmodium falciparum malaria cases along international border of north east India.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Bangladesh; Chloroquine; Dru | 2018 |
Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasites.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transport Proteins; Par | 2018 |
Prevalence of chloroquine resistance alleles among Plasmodium falciparum parasites in countries affected by malaria disease since change of treatment policy: a systematic review protocol.
Topics: Alleles; Animals; Antimalarials; Chloroquine; Drug Resistance; Guideline Adherence; Humans; Malaria, | 2018 |
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
Topics: Animals; Antimalarials; Cambodia; Cell Shape; Chloroquine; Drug Resistance; Gene Dosage; Gene Editin | 2018 |
[Polymorphism of 72-76 Coding Sequence within Exon 2 Region of Pfcrt in Yunnan Province].
Topics: Africa; Amino Acid Sequence; Antimalarials; Base Sequence; China; Chloroquine; Drug Resistance; Exon | 2016 |
[Analysis of Pfcrt Gene Polymorphism in Imported Falciparum Malaria Cases in Henan Province in 2015].
Topics: Africa; Antimalarials; Base Sequence; Chloroquine; Drug Resistance; Haplotypes; Humans; Malaria, Fal | 2016 |
[Detection of Genetic Mutations Associated with Drug Resistance in Imported Plasmodium falciparum].
Topics: Africa; Antimalarials; Chloroquine; DNA Primers; Drug Resistance; Malaria, Falciparum; Membrane Tran | 2016 |
In silico modeling of Plasmodium falciparum chloroquine resistance transporter protein and biochemical studies suggest its key contribution to chloroquine resistance.
Topics: Animals; Antimalarials; Chloroquine; Computer Simulation; Drug Resistance; Humans; Malaria, Falcipar | 2019 |
No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Res | 2018 |
Low rates of Plasmodium falciparum Pfcrt K76T mutation in three sentinel sites of malaria monitoring in Côte d'Ivoire.
Topics: Adolescent; Adult; Age Distribution; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Cote | 2018 |
Towards a re-emergence of chloroquine sensitivity in Côte d'Ivoire?
Topics: Antimalarials; Chloroquine; Cote d'Ivoire; Drug Resistance; Malaria, Falciparum; Membrane Transport | 2018 |
Artemisinin Resistance Outside of Southeast Asia.
Topics: Africa South of the Sahara; Antimalarials; Artemisinins; Asia, Southeastern; Chloroquine; Drug Resis | 2018 |
Evidence of Self-Medication with Chloroquine before Consultation for Malaria in the Southern Pacific Coast Region of Colombia.
Topics: Adolescent; Adult; Alleles; Antimalarials; Chloroquine; Colombia; Drug Resistance, Multiple; Female; | 2019 |
Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Studies; Dru | 2018 |
Dihydroartemisinin-Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and the Relationship to Emerging Artemisinin Resistance.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Human | 2018 |
Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Aspartic Acid Endopeptidases | 2019 |
Targeting Asexual and Sexual Blood Stages of the Human Malaria Parasite P. falciparum with 7-Chloroquinoline-Based 1,2,3-Triazoles.
Topics: Antimalarials; Chloroquine; Humans; Inhibitory Concentration 50; Life Cycle Stages; Malaria, Falcipa | 2019 |
Application of the automated haematology analyzer XN-30 for discovery and development of anti-malarial drugs.
Topics: Antimalarials; Atovaquone; Automation, Laboratory; Chloroquine; Drug Discovery; Hematology; Humans; | 2019 |
Susceptibility of Plasmodium falciparum to artemisinins and Plasmodium vivax to chloroquine in Phuoc Chien Commune, Ninh Thuan Province, south-central Vietnam.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance, Multi | 2019 |
Plasmodium vivax transcriptomes reveal stage-specific chloroquine response and differential regulation of male and female gametocytes.
Topics: Antimalarials; Cell Cycle; Chloroquine; Female; Gene Expression Regulation; Genes, Protozoan; Genome | 2019 |
Antibody Biomarkers Associated with Sterile Protection Induced by Controlled Human Malaria Infection under Chloroquine Prophylaxis.
Topics: Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Biomarkers; Chloroquine; Clinical Trials | 2019 |
Artemisinin resistance-associated markers in Plasmodium falciparum parasites from the China-Myanmar border: predicted structural stability of K13 propeller variants detected in a low-prevalence area.
Topics: Algorithms; Alleles; Antimalarials; Artemisinins; China; Chloroquine; Drug Resistance; Genetic Varia | 2019 |
Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies.
Topics: Animals; Antimalarials; Chloroquine; Down-Regulation; Drug Resistance; Drug Therapy, Combination; Fo | 2019 |
An analysis of large structural variation in global Plasmodium falciparum isolates identifies a novel duplication of the chloroquine resistance associated gene.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Gene Deletion; Gene Duplication; Gen | 2019 |
Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites.
Topics: Animals; Antimalarials; B-Lymphocytes; Chemoprevention; Chloroquine; Humans; Malaria Vaccines; Malar | 2019 |
High Frequency of
Topics: Antimalarials; Child, Preschool; Chloroquine; Cote d'Ivoire; Drug Resistance; Gabon; Gene Frequency; | 2019 |
Antiplasmodial Activity and In Vivo Bio-Distribution of Chloroquine Molecules Released with a 4-(4-Ethynylphenyl)-Triazole Moiety from Organometallo-Cobalamins.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Molecular Structure; Organ | 2019 |
In vitro synergistic interaction of potent 4-aminoquinolines in combination with dihydroartemisinin against chloroquine-resistant Plasmodium falciparum.
Topics: Aminoquinolines; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Synergism; Drug The | 2019 |
Evolution of Plasmodium falciparum drug resistance genes following artemisinin combination therapy in Sudan.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; DNA, Protozoan; Drug | 2019 |
Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents.
Topics: Antimalarials; Chloroquine; Erythrocytes; HEK293 Cells; Humans; Malaria, Falciparum; Molecular Struc | 2019 |
Efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in Honduras.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Genotype; Honduras; | 2013 |
Association between prevalence of chloroquine resistance and unusual mutation in pfmdr-I and pfcrt genes in India.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Drug Resistance; Female; Genoty | 2013 |
Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys.
Topics: Administration, Oral; Animals; Antimalarials; Aotus trivirgatus; Benzylisoquinolines; Chloroquine; D | 2013 |
Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.
Topics: Adolescent; Adult; Animals; Anopheles; Antigens, Protozoan; Antimalarials; Chloroquine; Erythrocytes | 2013 |
Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.
Topics: Adolescent; Adult; Animals; Anopheles; Antigens, Protozoan; Antimalarials; Chloroquine; Erythrocytes | 2013 |
Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.
Topics: Adolescent; Adult; Animals; Anopheles; Antigens, Protozoan; Antimalarials; Chloroquine; Erythrocytes | 2013 |
Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.
Topics: Adolescent; Adult; Animals; Anopheles; Antigens, Protozoan; Antimalarials; Chloroquine; Erythrocytes | 2013 |
Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger.
Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Ethanolamines; Fluorenes; Hu | 2013 |
High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.
Topics: Amodiaquine; Antimalarials; Artemisinins; Automation, Laboratory; Chloroquine; Drug Resistance; Drug | 2013 |
Prevalence of the molecular marker of Plasmodium falciparum resistance to chloroquine and sulphadoxine/pyrimethamine in Benin seven years after the change of malaria treatment policy.
Topics: Adolescent; Antimalarials; Benin; Blood; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Drug | 2013 |
The role of Pfmdr1 and Pfcrt in changing chloroquine, amodiaquine, mefloquine and lumefantrine susceptibility in western-Kenya P. falciparum samples during 2008-2011.
Topics: Amodiaquine; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Ethanolamines; Fluorenes; | 2013 |
Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Antimalarials; Cell Membrane; Chloroquine; Drug Resistance; Erythrocyt | 2013 |
Haemoglobin dynamics in Papuan and non-Papuan adults in northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria.
Topics: Adolescent; Adult; Anemia; Antimalarials; Chloroquine; Doxycycline; Female; Hemoglobins; Humans; Ind | 2013 |
Microsatellite analysis of chloroquine resistance associated alleles and neutral loci reveal genetic structure of Indian Plasmodium falciparum.
Topics: Alleles; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Genes, Protozoan; Haplotypes; | 2013 |
[Prevalence of Plasmodium falciparum, anemia and molecular markers of chloroquine and sulfadoxine-pyriméthamine resistance in delivered women in Fana, Mali].
Topics: Adolescent; Adult; Anemia; Chloroquine; Delivery, Obstetric; Drug Combinations; Drug Resistance; Fem | 2013 |
Stage-specific cytosolic protein kinase C-like activity in human malarial parasite Plasmodium falciparum.
Topics: Adenosine Triphosphate; Antimalarials; Calcium; Chloroquine; Cytosol; Erythrocytes; Gene Expression | 2005 |
Trends in antimalarial drug use in Africa.
Topics: Africa; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Health Surveys | 2013 |
Importation of chloroquine-resistant Plasmodium falciparum by Guatemalan peacekeepers returning from the Democratic Republic of the Congo.
Topics: Adult; Antimalarials; Chloroquine; Democratic Republic of the Congo; Drug Resistance; Guatemala; Hum | 2013 |
Model system to define pharmacokinetic requirements for antimalarial drug efficacy.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Humans; Malaria, Falcipar | 2013 |
Occurrence of multiple chloroquine-resistant Pfcrt haplotypes and emergence of the S(agt)VMNT type in Cameroonian Plasmodium falciparum.
Topics: Cameroon; Chloroquine; Haplotypes; Humans; Malaria, Falciparum; Membrane Transport Proteins; Plasmod | 2014 |
Reduced heterozygosity at intragenic and flanking microsatellites of pfcrt gene establishes natural selection based molecular evolution of chloroquine-resistant Plasmodium falciparum in India.
Topics: Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Evolution, Molecular; Genetic Variation | 2013 |
Analyses of genetic variations at microsatellite loci present in-and-around the Pfcrt gene in Indian Plasmodium falciparum.
Topics: Antimalarials; Base Sequence; Chloroquine; DNA, Protozoan; Drug Resistance; Evolution, Molecular; Ge | 2013 |
Surveillance of travellers: an additional tool for tracking antimalarial drug resistance in endemic countries.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Child; Child, Preschool; Chloroquine; DNA | 2013 |
Low prevalence of the molecular markers of Plasmodium falciparum resistance to chloroquine and sulphadoxine/pyrimethamine in asymptomatic children in Northern Benin.
Topics: Adolescent; Animals; Antimalarials; Benin; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Dru | 2013 |
A SYBR Green 1-based in vitro test of susceptibility of Ghanaian Plasmodium falciparum clinical isolates to a panel of anti-malarial drugs.
Topics: Antimalarials; Benzothiazoles; Child; Child, Preschool; Chloroquine; Diamines; Drug Resistance; Ghan | 2013 |
Pre-erythrocytic antibody profiles induced by controlled human malaria infections in healthy volunteers under chloroquine prophylaxis.
Topics: Antibodies; Antibody Formation; Antigens, Protozoan; Antimalarials; Chloroquine; Erythrocytes; Healt | 2013 |
Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.
Topics: Antimalarials; Child, Preschool; Chloroquine; Democratic Republic of the Congo; DNA, Protozoan; Drug | 2013 |
Metabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolism.
Topics: Antimalarials; Chloroquine; Chromosome Mapping; Drug Resistance; Hemoglobins; Humans; Malaria, Falci | 2014 |
To kill or not to kill, that is the question: cytocidal antimalarial drug resistance.
Topics: Antimalarials; Chloroquine; Drug Discovery; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium | 2014 |
The treatment of Plasmodium falciparum malaria with a single dose antimalarial; a preliminary report of the use of hydroxychloroquine, 7-chloro-4(4-(N-ethyl-N-B-hydroxyethylamino)-1-methylbutylamino)-quinoline diphosphate.
Topics: Antimalarials; Chloroquine; Humans; Hydroxychloroquine; Malaria; Malaria, Falciparum; Quinolines | 1952 |
Molecular analysis of chloroquine and sulfadoxine-pyrimethamine resistance-associated alleles in Plasmodium falciparum isolates from Nicaragua.
Topics: Alleles; Antimalarials; Chloroquine; Dihydropteroate Synthase; DNA, Protozoan; Drug Combinations; Dr | 2014 |
Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria.
Topics: Acute Disease; Adult; Antimalarials; Artemisinins; Chloroquine; Corpus Callosum; Drug Therapy, Combi | 2014 |
Single nucleotide polymorphisms in Plasmodium falciparum V type H(+) pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms.
Topics: Adult; Alleles; Antimalarials; Base Sequence; Child; Chloroquine; DNA, Protozoan; Drug Resistance; G | 2014 |
Treatment of erythrocytes with the 2-cys peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine.
Topics: Animals; Antimalarials; Apoptosis; Cells, Cultured; Chloroquine; Cysteine; Erythrocytes; Homeodomain | 2014 |
Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum.
Topics: Adult; Animals; Anopheles; Antibodies, Protozoan; Antimalarials; Chloroquine; Erythrocytes; Humans; | 2014 |
Return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi.
Topics: Antimalarials; Child, Preschool; Chloroquine; Cross-Sectional Studies; Genotype; Genotyping Techniqu | 2014 |
High prevalence of PfCRT K76T mutation in Plasmodium falciparum isolates in Ghana.
Topics: Adult; Animals; Antimalarials; Chloroquine; Ghana; Humans; Malaria, Falciparum; Membrane Transport P | 2014 |
Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter.
Topics: Amino Acid Sequence; Animals; Biological Transport; Chloroquine; Drug Resistance; Haplotypes; Kineti | 2014 |
A cross-sectional survey of Plasmodium falciparum pfcrt mutant haplotypes in the Democratic Republic of Congo.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Cross-Sectional Studies; Democratic | 2014 |
Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Child, Preschool; Chl | 2014 |
Imported malaria is stable from Africa but declining from Asia.
Topics: Adolescent; Adult; Africa; Aged; Antimalarials; Asia; Atovaquone; Chemoprevention; Child; Child, Pre | 2014 |
Quality of antimalarial drugs and antibiotics in Papua New Guinea: a survey of the health facility supply chain.
Topics: Amodiaquine; Amoxicillin; Antimalarials; Artemether; Artemisinins; Biosimilar Pharmaceuticals; Chlor | 2014 |
Plasmodium falciparum multidrug resistance protein 1 (pfmrp1) gene and its association with in vitro drug susceptibility of parasite isolates from north-east Myanmar.
Topics: Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Chloroquine; | 2014 |
A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum.
Topics: Antimalarials; Biological Transport; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Memb | 2014 |
Pfcrt mutant haplotypes may not correspond with chloroquine resistance.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Developing Countries; Drug R | 2014 |
Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs.
Topics: Animals; Antimalarials; Cell Death; Chloroquine; Dendrimers; Drug Carriers; Drug Delivery Systems; E | 2014 |
Imported malaria in a non-endemic area: the experience of the university of Campinas hospital in the Brazilian Southeast.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Anemia; Antimalarials; Artemether; Artemisini | 2014 |
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.
Topics: Amino Acid Substitution; Amodiaquine; Antimalarials; Artemether; Artemisinins; Child; Child, Prescho | 2014 |
Double mutation in the pfmdr1 gene is associated with emergence of chloroquine-resistant Plasmodium falciparum malaria in Eastern India.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Multidrug Resistanc | 2014 |
The origins of antimalarial-drug resistance.
Topics: Antimalarials; Artemisinins; Cambodia; Chloroquine; Drug Resistance; Drug Therapy, Combination; Hist | 2014 |
Antimalarial activity of the myxobacterial macrolide chlorotonil a.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Hydrocarbons, Chlorinated; Macrolides | 2014 |
[Epidemiological characteristics of malaria in the village of Corail, Grand'Anse, Haiti].
Topics: Adolescent; Adult; Aged; Antimalarials; Asymptomatic Diseases; Child; Child, Preschool; Chloroquine; | 2014 |
Molecular evidence of increased resistance to anti-folate drugs in Plasmodium falciparum in North-East India: a signal for potential failure of artemisinin plus sulphadoxine-pyrimethamine combination therapy.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Codon; Drug Co | 2014 |
Antiplasmodial activity-aided isolation and identification of quercetin-4'-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Cell Line; Chloroquine; Chromolaena; Drug Resistan | 2014 |
Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.
Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Biological Transport; Child; Chloroquine; Drug Resi | 2014 |
Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity.
Topics: Aminoquinolines; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Cryopreservation; | 2014 |
Pfcrt 76T and pfmdr1 86Y allele frequency in Plasmodium falciparum isolates and use of self-medication in a rural area of Gabon.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Gabon; Ge | 2014 |
Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.
Topics: Amino Acid Sequence; Antimalarials; Artemisinins; Biological Transport; Chloroquine; Chromosomes; Dr | 2014 |
Clonal outbreak of Plasmodium falciparum infection in eastern Panama.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Cluster Analysis; Colo | 2015 |
Detection of single-nucleotide polymorphisms in Plasmodium falciparum by PCR primer extension and lateral flow immunoassay.
Topics: Antimalarials; Chloroquine; DNA Primers; DNA, Protozoan; Drug Resistance; Immunoassay; Malaria, Falc | 2015 |
Genotyping of chloroquine resistant Plasmodium falciparum in wild caught Anopheles minimus mosquitoes in a malaria endemic area of Assam, India.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Endemic Diseases; G | 2014 |
Therapeutic efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum in Haiti after many decades of its use.
Topics: Antimalarials; Chloroquine; Drug Resistance; Female; Haiti; Humans; Malaria, Falciparum; Male; Plasm | 2015 |
Polymorphisms of the Pfatpase 6 and Pfcrt gene and their relationship with the in vitro susceptibility to dihydroartemisinin and chloroquine of Plasmodium falciparum isolates from Abobo, Côte d'Ivoire.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Cote d'Ivoire; Drug Resistance; Gene Expression R | 2014 |
Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite.
Topics: Animals; Chloroquine; Drug Resistance; Gene Expression Regulation; Genetic Variation; Humans; Malari | 2015 |
Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae).
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Antiprotozoal Agents; Cell Line; Chloroquine; Ethn | 2015 |
Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay.
Topics: Antimalarials; Artemisinins; Blood Cells; Chloroquine; Flow Cytometry; Hemeproteins; Humans; Inhibit | 2015 |
Knowledge, attitudes, and practices concerning malaria in pregnancy: results from a qualitative study in Madang, Papua New Guinea.
Topics: Adult; Antimalarials; Chloroquine; Female; Focus Groups; Health Knowledge, Attitudes, Practice; Huma | 2015 |
Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.
Topics: Chloroquine; Drug Resistance; Erythrocytes; Gene Frequency; Haplotypes; Humans; Malaria, Falciparum; | 2015 |
Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Studies; Drug Resistance; Femal | 2015 |
A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum.
Topics: Antigenic Variation; Antigens, Protozoan; Azepines; Chloroquine; Gene Expression Regulation; Genetic | 2015 |
Survey of chloroquine-resistant mutations in the Plasmodium falciparum pfcrt and pfmdr-1 genes in Hadhramout, Yemen.
Topics: Adolescent; Adult; Aged; Alleles; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistan | 2015 |
Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy.
Topics: Animals; Antibodies; Antigens, Protozoan; Antimalarials; Carrier Proteins; Chloroquine; Drug Deliver | 2015 |
Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Cambodia; Chloroquine; Drug Resistance; Female | 2015 |
Changing Malaria Prevalence on the Kenyan Coast since 1974: Climate, Drugs and Vector Control.
Topics: Adolescent; Adult; Aged; Antimalarials; Bayes Theorem; Child; Child, Preschool; Chloroquine; Climate | 2015 |
In silico attempt for adduct agent(s) against malaria: Combination of chloroquine with alkaloids of Adhatoda vasica.
Topics: Alkaloids; Chloroquine; Humans; Malaria, Falciparum | 2015 |
Therapeutic assessment of chloroquine-primaquine combined regimen in adult cohort of Plasmodium vivax malaria from a tertiary care hospital in southwestern India.
Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Coinfection; Drug Therapy, Combination; Female; | 2015 |
Chloroquine sensitivity: diminished prevalence of chloroquine-resistant gene marker pfcrt-76 13 years after cessation of chloroquine use in Msambweni, Kenya.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Codon; Drug Resistance; Female; Genetic Markers | 2015 |
In Vitro and Molecular Surveillance for Antimalarial Drug Resistance in Plasmodium falciparum Parasites in Western Kenya Reveals Sustained Artemisinin Sensitivity and Increased Chloroquine Sensitivity.
Topics: Alleles; Amodiaquine; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Dr | 2015 |
Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso.
Topics: Antimalarials; Burkina Faso; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Tra | 2015 |
Comparative Study of Effectiveness and Resistance Profile of Chloroquine and Sulfadoxine-Pyrimethamine in Uncomplicated Plasmodium falciparum Malaria in Kolkata.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Female; Hu | 2015 |
Characterizing Types of Human Mobility to Inform Differential and Targeted Malaria Elimination Strategies in Northeast Cambodia.
Topics: Animals; Anopheles; Antimalarials; Artemisinins; Artesunate; Cambodia; Chloroquine; Disease Eradicat | 2015 |
[Malaria and intestinal protozoa].
Topics: Animals; Antimalarials; Chloroquine; Humans; Incidence; Intestines; Malaria, Falciparum | 2016 |
Assessment of the Worldwide Antimalarial Resistance Network Standardized Procedure for In Vitro Malaria Drug Sensitivity Testing Using SYBR Green Assay for Field Samples with Various Initial Parasitemia Levels.
Topics: Antimalarials; Artemisinins; Atovaquone; Benzothiazoles; Biological Assay; Chloroquine; Diamines; DN | 2016 |
High prevalence of Plasmodium falciparum pfcrt K76T mutation in children with sickle cell disease at a tertiary hospital in north-western Tanzania.
Topics: Anemia, Sickle Cell; Child, Preschool; Chloroquine; Drug Resistance; Endemic Diseases; Female; Human | 2014 |
Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.
Topics: Alleles; Antimalarials; Chloroquine; Drug Resistance; Haplotypes; Humans; Malaria, Falciparum; Membr | 2016 |
Within-host competition and drug resistance in the human malaria parasite Plasmodium falciparum.
Topics: Angola; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Ghana; Humans; Infant; | 2016 |
Comparative assessment on the prevalence of mutations in the Plasmodium falciparum drug-resistant genes in two different ecotypes of Odisha state, India.
Topics: Alleles; Antimalarials; Chloroquine; Dihydropteroate Synthase; Drug Combinations; Drug Resistance; E | 2016 |
Malaria wars.
Topics: Antimalarials; Artemisinins; Cambodia; Chloroquine; Disease Eradication; Drug Resistance, Microbial; | 2016 |
Breadth of humoral response and antigenic targets of sporozoite-inhibitory antibodies associated with sterile protection induced by controlled human malaria infection.
Topics: Animals; Antibodies, Neutralizing; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Chloro | 2016 |
Molecular mutation profile of pfcrt in Plasmodium falciparum isolates imported from Africa in Henan province.
Topics: Adolescent; Adult; Africa; Aged; Antimalarials; China; Chloroquine; Drug Resistance; Female; Gene Fr | 2016 |
Antiplasmodial activity of selected medicinal plants used to treat malaria in Ghana.
Topics: Antimalarials; Cell Line; Chloroquine; Ghana; Humans; Malaria, Falciparum; Medicine, Traditional; Ph | 2016 |
A link between poor quality antimalarials and malaria drug resistance?
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Drug Therap | 2016 |
Malaria research and its influence on anti-malarial drug policy in Malawi: a case study.
Topics: Antimalarials; Artemether; Artemisinins; Biomedical Research; Chloroquine; Drug Combinations; Drug R | 2016 |
Highly active ozonides selected against drug resistant malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Disease Models, Animal; Female; Human | 2016 |
Does Malaria Cause Hypertension?
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Hypertension; Malaria; Malaria, Falciparum | 2016 |
Molecular markers associated with resistance to commonly used antimalarial drugs among Plasmodium falciparum isolates from a malaria-endemic area in Taiz governorate-Yemen during the transmission season.
Topics: Alleles; Antimalarials; Artemisinins; Artesunate; Chloroquine; Cross-Sectional Studies; Dihydroptero | 2016 |
Analysis of genetic diversity in the chloroquine-resistant gene Pfcrt in field Plasmodium falciparum isolates from five regions of the southern Cameroon.
Topics: Antimalarials; Cameroon; Chloroquine; Drug Resistance; Genetic Variation; Genotype; Linkage Disequil | 2016 |
Transcriptomic Analysis of Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium falciparum: Toward Malaria Diagnostics and Therapeutics for Global Health.
Topics: Antimalarials; Chloroquine; Drug Resistance; Gene Expression Profiling; Global Health; Humans; Malar | 2016 |
Plasmodium falciparum Drug-Resistant Haplotypes and Population Structure in Postearthquake Haiti, 2010.
Topics: Alleles; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Earthquakes; Genetics, Popu | 2016 |
Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter.
Topics: Amantadine; Animals; Antimalarials; Biological Transport; Blotting, Western; Chloroquine; Drug Resis | 2016 |
Polymorphisms in Pfcrt and Pfmdr-1 genes after five years withdrawal of chloroquine for the treatment of Plasmodium falciparum malaria in West Bengal, India.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance, Micro | 2016 |
Prevalence of crt and mdr-1 mutations in Plasmodium falciparum isolates from Grande Comore island after withdrawal of chloroquine.
Topics: Adult; Amino Acid Substitution; Antimalarials; Child; Child, Preschool; Chloroquine; Comoros; Drug U | 2016 |
3D QSAR, pharmacophore and molecular docking studies of known inhibitors and designing of novel inhibitors for M18 aspartyl aminopeptidase of Plasmodium falciparum.
Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Design; Glutamyl Aminopeptidase; Humans; Malaria, | 2016 |
Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda.
Topics: Adolescent; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Dru | 2016 |
Prevalence of Plasmodium falciparum Molecular Markers of Antimalarial Drug Resistance in a Residual Malaria Focus Area in Sabah, Malaysia.
Topics: Adult; Alleles; Antimalarials; Biomarkers; Child; Chloroquine; Drug Combinations; Drug Resistance; G | 2016 |
Plasmodium falciparum Genetic Diversity in Continental Equatorial Guinea before and after Introduction of Artemisinin-Based Combination Therapy.
Topics: Amodiaquine; Antigens, Protozoan; Antimalarials; Artemisinins; Artesunate; Chloroquine; DNA Copy Num | 2017 |
In vitro sensitivity of antimalarial drugs and correlation with clinico-parasitological response following treatment with a 3-day artesunate-mefloquine combination in patients with falciparum malaria along the Thai-Myanmar border.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Administration Schedul | 2017 |
Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy.
Topics: Administration, Oral; Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Dr | 2017 |
Recrudescence of
Topics: Administration, Intravenous; Adult; Antimalarials; Chemoprevention; Chloroquine; Female; Gravidity; | 2017 |
Association between Polymorphisms in the Pf
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; | 2017 |
Establishment and application of a novel isothermal amplification assay for rapid detection of chloroquine resistance (K76T) in Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; DNA Primers; DNA, Protozoan; Drug Resistance; Humans; Malaria, Falciparu | 2017 |
A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs.
Topics: Antimalarials; Chloroquine; Drug Resistance; Fluorescent Dyes; Hydrogen-Ion Concentration; Malaria, | 2017 |
Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs.
Topics: Animals; Antimalarials; Chloroquine; Drug Discovery; Female; Heme; Hemeproteins; Malaria, Falciparum | 2017 |
Anti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Female; Humans; Malaria; Malaria, Falci | 2017 |
Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations.
Topics: Antimalarials; Artemisinins; Atovaquone; Chloroquine; Computational Biology; Drug Combinations; Drug | 2017 |
The Malaria TaqMan Array Card Includes 87 Assays for Plasmodium falciparum Drug Resistance, Identification of Species, and Genotyping in a Single Reaction.
Topics: Antimalarials; Artemisinins; Atovaquone; Chloroquine; Drug Resistance; Epidemiological Monitoring; G | 2017 |
Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976-78.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Liberia; Malaria, Falc | 2017 |
[Self-medication in the treatment of acute malaria: study based on users of private health drug stores in Ouagadougou, Burkina Faso].
Topics: Acute Disease; Adult; Antimalarials; Artemisinins; Burkina Faso; Child; Chloroquine; Cross-Sectional | 2008 |
Diminished Plasmodium falciparum sensitivity to quinine exposure in vitro and in a sequential multi-drug regimen: A preliminary investigation in Guyana, South America.
Topics: Animals; Antimalarials; Child; Chloroquine; Doxycycline; Drug Administration Schedule; Drug Resistan | 2008 |
Molecular epidemiology of drug-resistant malaria in western Kenya highlands.
Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Dihydropteroate Synthase; DNA, Protozoan; Dr | 2008 |
Accumulation of CVIET Pfcrt allele of Plasmodium falciparum in placenta of pregnant women living in an urban area of Dakar, Senegal.
Topics: Adolescent; Adult; Animals; Antigens, Protozoan; Blood; Chemoprevention; Child; Chloroquine; DNA, Pr | 2008 |
Predictors of antimalarial treatment failure in an area of unstable malaria transmission in eastern Sudan.
Topics: Adolescent; Age Factors; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Studie | 2009 |
Therapeutic responses of Plasmodium vivax and P. falciparum to chloroquine, in an area of western India where P. vivax predominates.
Topics: Administration, Oral; Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquin | 2008 |
[Is the antimalarial fight effective in Mayotte?].
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Comoros; Drug Combinations; Female; Humans; | 2008 |
Monitoring Plasmodium falciparum chloroquine resistance in Yunnan Province, China, 1981-2006.
Topics: Amodiaquine; Animals; Antimalarials; China; Chloroquine; Drug Resistance; Humans; Inhibitory Concent | 2008 |
Mutation in pfmdr1 gene in chloroquine-resistant Plasmodium falciparum isolates, Southeast Iran.
Topics: Animals; Antimalarials; Base Sequence; Chloroquine; Drug Resistance; Humans; Iran; Malaria, Falcipar | 2008 |
The bioactivity of novel furanoterpenoids isolated from Siphonochilus aethiopicus.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Chloroquine; CHO Cells; Cricetinae | 2009 |
Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola.
Topics: Adolescent; Angola; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Dihydropteroate Sy | 2008 |
Malariological baseline survey and in vitro antimalarial drug resistance in Gulu district, Northern Uganda.
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chlor | 2008 |
The evolution of drug-resistant malaria.
Topics: Africa; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Evolution, Molecular; Humans | 2009 |
High prevalence of Plasmodium falciparum Pfmdr1 86Y mutant gene in sickle cell disease in Nigeria.
Topics: Analysis of Variance; Anemia, Sickle Cell; Animals; Antibiotic Prophylaxis; Antimalarials; Chi-Squar | 2008 |
Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women.
Topics: Adult; Animals; Antigens, Protozoan; Antimalarials; Chloroquine; Drug Combinations; Female; Genotype | 2009 |
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia.
Topics: Adult; Animals; Antimalarials; Artemisinins; Artesunate; Cambodia; Child; Chloroquine; Drug Therapy, | 2009 |
Violacein extracted from Chromobacterium violaceum inhibits Plasmodium growth in vitro and in vivo.
Topics: Animals; Antimalarials; Chloroquine; Chromobacterium; Drug Resistance; Humans; Indoles; Malaria; Mal | 2009 |
Nonradioactive heteroduplex tracking assay for the detection of minority-variant chloroquine-resistant Plasmodium falciparum in Madagascar.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Gene Amplification; G | 2009 |
Analysis of genetic mutations associated with anti-malarial drug resistance in Plasmodium falciparum from the Democratic Republic of East Timor.
Topics: Adolescent; Adult; Alleles; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Gen | 2009 |
Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.
Topics: Africa; Alleles; Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; DNA, Protozoan; Drug | 2009 |
In vitro activity of pyronaridine against Plasmodium falciparum and comparative evaluation of anti-malarial drug susceptibility assays.
Topics: Administration, Oral; Adolescent; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Artesun | 2009 |
Anti-malarial prescriptions in three health care facilities after the emergence of chloroquine resistance in Niakhar, Senegal (1992-2004).
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Fa | 2009 |
Genetic structure of Plasmodium falciparum populations between lowland and highland sites and antimalarial drug resistance in Western Kenya.
Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Endemic | 2009 |
Chloroquine-resistant haplotype Plasmodium falciparum parasites, Haiti.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antimalarials; Child; Child, Preschool; Chloroq | 2009 |
Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the United Kingdom.
Topics: Adult; Alleles; Amino Acid Sequence; Animals; Antimalarials; Atovaquone; Chloroquine; Dihydropteroat | 2009 |
Chloroquine resistance before and after its withdrawal in Kenya.
Topics: Animals; Antimalarials; Chloroquine; Drug Approval; Drug Combinations; Drug Resistance; Genotype; Hu | 2009 |
A unique methodology for detecting the spread of chloroquine-resistant strains of Plasmodium falciparum, in previously unreported areas, by analyzing anophelines of malaria endemic zones of Orissa, India.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Drug Resistance; Endemic Diseases; Humans; India; In | 2009 |
Plasmodium falciparum gametocytaemia with chloroquine chemotherapy in persistent malaria in an endemic area of India.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistan | 2009 |
Molecular markers of chloroquine resistance in Plasmodium falciparum in Sri Lanka: frequency before revision of the antimalarial drug policy.
Topics: Animals; Antimalarials; Biomarkers; Chloroquine; Drug Monitoring; Drug Resistance; Humans; Malaria, | 2009 |
Association of molecular markers in Plasmodium falciparum crt and mdr1 with in vitro chloroquine resistance: a Philippine study.
Topics: Antimalarials; Chloroquine; Drug Resistance; Genetic Markers; Humans; Malaria, Falciparum; Membrane | 2009 |
Chloroquine and sulphadoxine-pyrimethamine sensitivity of Plasmodium falciparum parasites in a Brazilian endemic area.
Topics: Animals; Antimalarials; Brazil; Chloroquine; Drug Combinations; Drug Resistance; Endemic Diseases; H | 2009 |
Low level genotypic chloroquine resistance near Malawi's northern border with Tanzania.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Ge | 2009 |
Seasonal fluctuation of drug-resistant malaria parasites: a sign of fitness cost.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transpor | 2009 |
Clinical and laboratory features of human Plasmodium knowlesi infection.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Blood Chemical Analysis; Chloroquine; Female; Hemog | 2009 |
The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification.
Topics: Animals; Carrier Proteins; Cell Extracts; Chloroquine; Cytosol; Erythrocytes; Fluorescent Antibody T | 2009 |
Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Antimalarials; Biological Transport, Active; Chloroquine; Dru | 2009 |
Molecular assessment of Plasmodium falciparum resistance to antimalarial drugs in China.
Topics: Animals; Antimalarials; China; Chloroquine; Drug Resistance, Multiple; Humans; Malaria, Falciparum; | 2009 |
Molecular surveillance of Plasmodium falciparum chloroquine resistance transporter variant T76 in Jazan area, Kingdom of Saudi Arabia.
Topics: Animals; Antimalarials; Base Sequence; Chloroquine; DNA, Protozoan; Drug Resistance; Genetic Markers | 2009 |
Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance; Gene Dosage; Genetic Markers; | 2010 |
Therapeutic efficacy of chloroquine and sequence variation in pfcrt gene among patients with falciparum malaria in central India.
Topics: Adolescent; Adult; Age Factors; Animals; Antigens, Protozoan; Antimalarials; Child; Child, Preschool | 2010 |
Haemoglobin interference and increased sensitivity of fluorimetric assays for quantification of low-parasitaemia Plasmodium infected erythrocytes.
Topics: Animals; Benzothiazoles; Cell Separation; Chloroquine; Cytophotometry; Diamines; DNA, Protozoan; Ery | 2009 |
The long shadow of malaria interventions in tropical Africa.
Topics: Africa South of the Sahara; Antimalarials; Chloroquine; Humans; Malaria, Falciparum | 2009 |
Evidence of selective sweeps in genes conferring resistance to chloroquine and pyrimethamine in Plasmodium falciparum isolates in India.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Genes, Protozoan; Genotype; Humans; India; Mal | 2010 |
A molecular map of chloroquine resistance in Mali.
Topics: Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Humans; Malaria, Falciparum; M | 2010 |
Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Therapy, Combination; Hista | 2009 |
Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance.
Topics: Adolescent; Aged; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; DNA, Pr | 2010 |
Plasmodium falciparum malaria, southern Algeria, 2007.
Topics: Algeria; Animals; Anopheles; Chloroquine; Disease Outbreaks; Disease Vectors; Humans; Insecticide Re | 2010 |
A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Fluorescent Dyes; Genotype; Humans; Indol | 2010 |
pfmdr1 amplification and fixation of pfcrt chloroquine resistance alleles in Plasmodium falciparum in Venezuela.
Topics: Alleles; Antimalarials; Base Sequence; Chloroquine; DNA Primers; DNA, Protozoan; Drug Resistance, Mu | 2010 |
Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placenta.
Topics: Adolescent; Adult; Animals; Blood; Chloroquine; Drug Resistance; Female; Gene Frequency; Humans; Mal | 2010 |
Flow cytometry for the evaluation of anti-plasmodial activity of drugs on Plasmodium falciparum gametocytes.
Topics: Anti-Infective Agents; Antimalarials; Artemisinins; Chloroquine; Drug Evaluation, Preclinical; Flow | 2010 |
Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007.
Topics: Antimalarials; Artemisinins; Artesunate; Cambodia; Chloroquine; Drug Resistance, Bacterial; Geograph | 2010 |
Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates.
Topics: Alleles; Amplified Fragment Length Polymorphism Analysis; Animals; Antimalarials; Chloroquine; Drug | 2010 |
Clustering of malaria treatment failure (TF) in Daraweesh: hints for host genetic susceptibility to TF with emphasis on immune-modulating SNPs.
Topics: Adolescent; Adult; Antibodies, Protozoan; Antimalarials; Chi-Square Distribution; Chloroquine; Clust | 2010 |
Dynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparum.
Topics: Adolescent; Adult; Aged; Alleles; Antimalarials; Black People; Child; Child, Preschool; Chloroquine; | 2010 |
Predictive factors of severe disease secondary to falciparum malaria among travelers.
Topics: Adolescent; Adult; Age Factors; Antimalarials; Asia, Southeastern; Child; Child, Preschool; Chloroqu | 2011 |
High chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from the island of Car Nicobar, India.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Dihydropteroate Synthase; DN | 2010 |
Active case detection, treatment of falciparum malaria with combined chloroquine and sulphadoxine/pyrimethamine and vivax malaria with chloroquine and molecular markers of anti-malarial resistance in the Republic of Vanuatu.
Topics: Adolescent; Adult; Antigens, Protozoan; Antimalarials; Case-Control Studies; Child; Child, Preschool | 2010 |
Malaria in Brazil: an overview.
Topics: Animals; Anopheles; Antimalarials; Brazil; Chloroquine; Female; Humans; Immunity, Innate; Incidence; | 2010 |
Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa.
Topics: Africa; Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Drug Resistance; Genotype; Humans; | 2010 |
Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.
Topics: Antimalarials; Cells, Cultured; Chloroquine; Drug Resistance; Erythrocytes; French Guiana; Humans; M | 2010 |
Rapid identification of chloroquine and atovaquone drug resistance in Plasmodium falciparum using high-resolution melt polymerase chain reaction.
Topics: Antimalarials; Atovaquone; Chloroquine; DNA, Protozoan; Drug Resistance; Haplotypes; Humans; Malaria | 2010 |
Glutathione transferase from Plasmodium falciparum--interaction with malagashanine and selected plant natural products.
Topics: Alkaloids; Biological Products; Chloroquine; Coumarins; Curcumin; Dinitrochlorobenzene; Drug Discove | 2010 |
Antimalarial activity of Aspilia pruliseta, a medicinal plant from Uganda.
Topics: Antimalarials; Asteraceae; Chloroquine; Diterpenes; Inhibitory Concentration 50; Malaria, Falciparum | 2010 |
Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene.
Topics: Adult; Angola; Antimalarials; Chloroquine; Drug Resistance; Female; Gene Frequency; Haplotypes; Huma | 2010 |
Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Genetics, Population; Genotype; Haploty | 2010 |
Chloroquine resistance: proposed mechanisms and countermeasures.
Topics: Alkaloids; Animals; Antimalarials; Chloroquine; Drug Design; Drug Resistance, Multiple; Humans; Mala | 2010 |
Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure.
Topics: Adolescent; Adult; Antimalarials; Cambodia; Child; Child, Preschool; Chloroquine; Chromatography, Li | 2010 |
The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dimerization; Dose-Response Relationship, Drug; Hemeprotein | 2011 |
Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Fem | 2010 |
Chloroquine clinical failures in P. falciparum malaria are associated with mutant Pfmdr-1, not Pfcrt in Madagascar.
Topics: Alleles; Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; DNA, Protozoan; Dru | 2010 |
On the mechanism of chloroquine resistance in Plasmodium falciparum.
Topics: Algorithms; Amebicides; Amino Acid Sequence; Animals; Biological Transport; Carbonyl Cyanide p-Trifl | 2010 |
Is chloroquine making a comeback?
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum | 2011 |
Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type.
Topics: Amodiaquine; Angola; Antimalarials; Chloroquine; Codon; Drug Resistance; Haplotypes; Humans; Malaria | 2010 |
A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro.
Topics: 3T3 Cells; Animals; Antimalarials; Cells, Cultured; Chloroquine; Drug Delivery Systems; Endothelial | 2011 |
Increased prevalence of the Plasmodium falciparum Pfmdr1 86N genotype among field isolates from Franceville, Gabon after replacement of chloroquine by artemether-lumefantrine and artesunate-mefloquine.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Child, Pr | 2011 |
Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Dihydropteroate Synthase; Dr | 2011 |
Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana.
Topics: Alleles; Amino Acid Substitution; Antimalarials; Biological Evolution; Child, Preschool; Chloroquine | 2011 |
Epidemic of Plasmodium falciparum malaria in Central India, an area where chloroquine has been replaced by artemisinin-based combination therapy.
Topics: Adolescent; Age Distribution; Antimalarials; Artemisinins; Child; Chloroquine; Drug Therapy, Combina | 2011 |
High frequency of PfCRT 76T in two Malian villages and its prevalence in severe relative to non-severe malaria.
Topics: Alleles; Case-Control Studies; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Drug Resistance | 2011 |
In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo.
Topics: Amino Acid Sequence; Antimalarials; Chloroquine; Congo; Drug Resistance; Genotype; Humans; Inhibitor | 2011 |
Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum.
Topics: Antimalarials; ATP-Binding Cassette Transporters; Base Sequence; Chloroquine; Drug Resistance; Gene | 2011 |
Factors associated with regional bias of pfcrt (plasmodium falciparum chloroquine resistance transporter) haplotypes in Nepal.
Topics: Antimalarials; Chloroquine; Drug Resistance; Female; Haplotypes; Humans; India; Logistic Models; Mal | 2011 |
Malaria epidemiology along Indo-Bangladesh border in Tripura State, India.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Drug Resistance; Humans; India; Insect Vectors; Inse | 2010 |
Detecting mutations in PfCRT and PfMDR1 genes among Plasmodium falciparum isolates from Saudi Arabia by pyrosequencing.
Topics: Amino Acid Substitution; Antimalarials; Chloroquine; DNA Primers; DNA, Protozoan; Drug Resistance; H | 2011 |
Population genetic analyses of Plasmodium falciparum chloroquine receptor transporter gene haplotypes reveal the evolutionary history of chloroquine-resistant malaria in India.
Topics: Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Evolution, Molecular; Haplotyp | 2011 |
Prevalence of molecular markers of anti-malarial drug resistance in Plasmodium vivax and Plasmodium falciparum in two districts of Nepal.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria, Falci | 2011 |
Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages.
Topics: Antimalarials; Atovaquone; Chloroquine; Erythrocytes; Malaria, Falciparum; Parasitemia; Plasmodium f | 2011 |
Malaria among patients and aid workers consulting a primary healthcare centre in Leogane, Haiti, November 2010 to February 2011 - a prospective observational study.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Earthquakes; Female; H | 2011 |
The mysteries of immunity to malaria.
Topics: Adaptive Immunity; Antibody Specificity; Antimalarials; Chloroquine; Endemic Diseases; Epitopes; Hum | 2011 |
Plasmodium knowlesi malaria in children.
Topics: Adolescent; Age Factors; Anemia; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans | 2011 |
High frequency of Plasmodium falciparum chloroquine resistance marker (pfcrt T76 mutation) in Yemen: an urgent need to re-examine malaria drug policy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Child; Child, Preschool; Chloroquine; Cro | 2011 |
Efficacy of chloroquine plus primaquine treatment and pfcrt mutation in uncomplicated falciparum malaria patients in Rangamati, Bangladesh.
Topics: Administration, Oral; Adolescent; Adult; Antimalarials; Bangladesh; Child; Child, Preschool; Chloroq | 2011 |
Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Dihydropteroate Synthase; Dr | 2011 |
Plasmodium falciparum: differential selection of drug resistance alleles in contiguous urban and peri-urban areas of Brazzaville, Republic of Congo.
Topics: Adolescent; Alleles; Animals; Anopheles; Antimalarials; Chloroquine; Congo; Drug Resistance; Female; | 2011 |
Indolone-N-oxide derivatives: in vitro activity against fresh clinical isolates of Plasmodium falciparum, stage specificity and in vitro interactions with established antimalarial drugs.
Topics: Adult; Antimalarials; Artemisinins; Cameroon; Chloroquine; Drug Interactions; Drug Resistance; Femal | 2011 |
Prolonged elevation of viral loads in HIV-1-infected children in a region of intense malaria transmission in Northern Uganda: a prospective cohort study.
Topics: Antimalarials; CD4 Lymphocyte Count; Child; Child, Preschool; Chloroquine; Disease Progression; Drug | 2010 |
Molecular markers of Plasmodium falciparum drug resistance in southern highland Rwanda.
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Fe | 2012 |
Human genetic variation is associated with Plasmodium falciparum drug resistance.
Topics: Adolescent; Adult; Alleles; Antimalarials; Aryl Hydrocarbon Hydroxylases; Black People; Burkina Faso | 2011 |
Plasmodium falciparum gametocyte carriage, sex ratios and asexual parasite rates in Nigerian children before and after a treatment protocol policy change instituting the use of artemisinin-based combination therapies.
Topics: Adolescent; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Therapy, Combina | 2011 |
Eritrean and Sudanese migrants presenting with malaria in Israel.
Topics: Adult; Antigens, Protozoan; Antimalarials; Chloroquine; Eritrea; Female; Hospitalization; Humans; Is | 2011 |
Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Haplotypes; Humans; Malaria, Falciparum; Membr | 2011 |
Large differences in prevalence of Pfcrt and Pfmdr1 mutations between Mwanza, Tanzania and Iganga, Uganda-a reflection of differences in policies regarding withdrawal of chloroquine?
Topics: Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Drug Resistance | 2012 |
Genetic backgrounds of the Plasmodium falciparum chloroquine resistant transporter (pfcrt) alleles in Pakistan.
Topics: Alleles; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Haplotypes; Humans; Malaria, F | 2012 |
Inhibitory activity of ferroquine, versus chloroquine, against western Kenya Plasmodium falciparum field isolates determined by a SYBR Green I in vitro assay.
Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance; Ferrous Compounds; Humans; Kenya; Mala | 2011 |
Drug resistance associated genetic polymorphisms in Plasmodium falciparum and Plasmodium vivax collected in Honduras, Central America.
Topics: Antimalarials; Chloroquine; Drug Resistance; Honduras; Humans; Malaria, Falciparum; Malaria, Vivax; | 2011 |
Identification of pyrimethamine- and chloroquine-resistant Plasmodium falciparum in Africa between 1984 and 1998: genotyping of archive blood samples.
Topics: Africa; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Genotype; Genotyping Techniques | 2011 |
Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.
Topics: Aminoquinolines; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine | 2012 |
In vitro antiplasmodial properties of Flacourtia flavescens Willd. (Flacourtiaceae) and Rytigynia canthioides (Benth.) Robyns (Rubiaceae).
Topics: Antimalarials; Benin; Chloroquine; In Vitro Techniques; Inhibitory Concentration 50; Malaria, Falcip | 2011 |
Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.
Topics: Aging; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Cohort Studies | 2012 |
Diversity of Plasmodium falciparum chloroquine resistance transporter (pfcrt) exon 2 haplotypes in the Pacific from 1959 to 1979.
Topics: Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Drug Resistance; Exons; Gene Flow; Genetic | 2012 |
High prevalence of pfcrt K76t mutants among Plasmodium falciparum isolates from Sabah, Malaysia.
Topics: Antimalarials; Chloroquine; Drug Resistance; Genes, Protozoan; Humans; Malaria, Falciparum; Malaysia | 2011 |
Saquinavir inhibits the malaria parasite's chloroquine resistance transporter.
Topics: Animals; Antimalarials; Biological Transport; Chloroquine; Drug Combinations; Drug Synergism; Female | 2012 |
The impact of three anopheline mosquito species in Toshka, on the introduction of chloroquine resistant P. falciparum to Egypt.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Drug Resistance; Egypt; Humans; Malaria, Falciparum; | 2011 |
Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso.
Topics: Adolescent; Antibodies, Protozoan; Antimalarials; Biomarkers; Burkina Faso; Child; Child, Preschool; | 2012 |
Can we teach an old drug new tricks?
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Humans; Mala | 2012 |
Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt.
Topics: Africa; Amino Acid Substitution; Antimalarials; Asia; Chloroquine; Cluster Analysis; Drug Resistance | 2012 |
Effect of chloroquine phosphate and toxic concentrations of lead acetate on Ca2+-ATPase activity in isolates and clones of Plasmodium falciparum.
Topics: Animals; Antimalarials; Calcium; Calcium-Transporting ATPases; Chloroquine; Drug Resistance; Homeost | 2011 |
Changes in genotypes of Plasmodium falciparum human malaria parasite following withdrawal of chloroquine in Tiwi, Kenya.
Topics: Antimalarials; Blood; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Drug Resistance; Genotyp | 2012 |
Prevalence of molecular markers of Plasmodium falciparum drug resistance in Dakar, Senegal.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Female; Gene Dosage; Gene Frequency; | 2012 |
Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal.
Topics: Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Drug Utilization; Gene Frequency; Human | 2012 |
Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Cinnamates; Drug Resistance; Erythrocytes; Humans; Malaria, Falciparum; | 2012 |
Chloroquine-resistant malaria in travelers returning from Haiti after 2010 earthquake.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Canada; Child; Child, Preschool; Chloroquine; Disas | 2012 |
Various pfcrt and pfmdr1 genotypes of Plasmodium falciparum cocirculate with P. malariae, P. ovale spp., and P. vivax in northern Angola.
Topics: Africa; Angola; Antimalarials; Chloroquine; Genotype; Humans; Malaria, Falciparum; Plasmodium falcip | 2012 |
The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia.
Topics: Adult; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Female; Humans; Malaria, Falcipa | 2012 |
[In vitro sensitivity of Plasmodium falciparum isolates from China-Myanmar border region to chloroquine, piperaquine and pyronaridine].
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; China; Chloroquine; Drug Resistance; Fema | 2012 |
Assessment of the molecular marker of Plasmodium falciparum chloroquine resistance (Pfcrt) in Senegal after several years of chloroquine withdrawal.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Administration Schedule; Drug Resistance; | 2012 |
Lack of evidence for chloroquine-resistant Plasmodium falciparum malaria, Leogane, Haiti.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Haplotypes; Humans; M | 2012 |
New insights into acquisition, boosting, and longevity of immunity to malaria in pregnant women.
Topics: Adult; Antibodies, Protozoan; Antimalarials; Case-Control Studies; Chloroquine; Female; Humans; Immu | 2012 |
2-Cys peroxiredoxin of Plasmodium falciparum is involved in resistance to heat stress of the parasite.
Topics: Animals; Antimalarials; Chloroquine; Cysteine; Cytoplasm; Erythrocytes; Gene Knockout Techniques; Ho | 2013 |
Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Cambodia; Child; Chloroquine; Drug Resistance; Drug | 2013 |
Assessing the cost-benefit effect of a Plasmodium falciparum drug resistance mutation on parasite growth in vitro.
Topics: Amodiaquine; Antimalarials; Biological Transport; Chloroquine; Drug Resistance; Genetic Fitness; Gen | 2013 |
Assessment and characterization of Ca2+-ATPase expression in selected isolates and clones of Plasmodium falciparum.
Topics: Calcium-Transporting ATPases; Chloroquine; Cloning, Molecular; Drug Resistance; Erythrocyte Membrane | 2012 |
Monitoring antimalarial drug resistance in India via sentinel sites: outcomes and risk factors for treatment failure, 2009-2010.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Microbial; Humans; India; Kaplan-Meier Es | 2012 |
4-aminoquinoline-triazine-based hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum.
Topics: Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Drug Resistance; Hep G2 | 2013 |
Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011.
Topics: Adolescent; Adult; Africa, Central; Africa, Western; Aged; Aged, 80 and over; Antimalarials; Child; | 2013 |
Molecular monitoring of antimalarial drug resistance among Plasmodium falciparum field isolates from Odisha, India.
Topics: Antimalarials; Artemisinins; Chloroquine; Cross-Sectional Studies; Drug Combinations; Drug Resistanc | 2013 |
Rapid selection of Plasmodium falciparum chloroquine resistance transporter gene and multidrug resistance gene-1 haplotypes associated with past chloroquine and present artemether-lumefantrine use in Inhambane District, southern Mozambique.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; DNA, Protozoan; | 2013 |
Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Humans | 2002 |
Assessment of therapeutic response of Plasmodium vivax and Plasmodium falciparum to chloroquine in a Malaria transmission free area in Colombia.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Colombia; Drug Resistance; Female; Fo | 2002 |
Rapid detection of a molecular marker for chloroquine-resistant falciparum malaria.
Topics: Animals; Antimalarials; Chloroquine; Cloning, Molecular; DNA, Protozoan; Drug Resistance; Fluorescen | 2002 |
Population genetics: malaria variorum.
Topics: Animals; Antimalarials; Chloroquine; Chromosomes; Drug Resistance; Evolution, Molecular; Genes, Prot | 2002 |
Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.
Topics: Alleles; Animals; Antimalarials; Chloroquine; Drug Resistance; Evolution, Molecular; Founder Effect; | 2002 |
Molecular epidemiology of malaria in cameroon. IX. Characteristics of recrudescent and persistent Plasmodium falciparum infections after chloroquine or amodiaquine treatment in children.
Topics: Amodiaquine; Animals; Antimalarials; Cameroon; Child, Preschool; Chloroquine; Chromatography, High P | 2002 |
Recurrent cerebellar syndrome following malaria.
Topics: Adult; Antimalarials; Cerebellar Diseases; Chloroquine; Chronic Disease; Drug Resistance; Humans; Ma | 2002 |
[A collective malarial infestation during a humanitarian mission in west Africa].
Topics: Adult; Altruism; Animals; Antimalarials; Body Weight; Chemoprevention; Chloroquine; Drug Resistance; | 2002 |
[Center of multidrug-resistant malaria in a forest zone of Cameroon revisited after 14 years].
Topics: Amodiaquine; Animals; Cameroon; Chloroquine; Drug Resistance, Multiple; Humans; Malaria, Falciparum; | 2002 |
The drug sensitivity and transmission dynamics of human malaria on Nias Island, North Sumatra, Indonesia.
Topics: Adolescent; Adult; Age Distribution; Aged; Animals; Anopheles; Antimalarials; Child; Child, Preschoo | 2002 |
Resistance to antimalarials.
Topics: Africa; Antimalarials; Chloroquine; Developing Countries; Drug Combinations; Drug Resistance, Multip | 2002 |
Reduced levels of chloroquine resistant Plasmodium falciparum in selected foci of the South West Province, Cameroon.
Topics: Adolescent; Adult; Animals; Cameroon; Child; Child, Preschool; Chloroquine; Cross-Sectional Studies; | 2001 |
In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasm | 2002 |
Molecular epidemiology of malaria in Cameroon. X. Evaluation of PFMDR1 mutations as genetic markers for resistance to amino alcohols and artemisinin derivatives.
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Base Sequence; Cameroon; Child; Child, Presc | 2002 |
Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America.
Topics: Alleles; Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Cloning, Molecular; Drug Resistan | 2002 |
Short report: Molecular evaluation of the efficacy of chloroquine treatment of uncomplicated Plasmodium falciparum malaria in East Timor.
Topics: Animals; Antigens, Protozoan; Antimalarials; Base Sequence; Chloroquine; DNA Primers; Genotype; Huma | 2002 |
Parasitology. A requiem for chloroquine.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Therapy, Combination; Drug | 2002 |
Plasmodium chloroquine resistance and the search for a replacement antimalarial drug.
Topics: Alleles; Animals; Antimalarials; ATP-Binding Cassette Transporters; Biological Evolution; Chloroquin | 2002 |
Monitoring the drug-sensitivity of Plasmodium falciparum in coastal towns in Madagascar by use of in vitro chemosensitivity and mutation detection tests.
Topics: Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Drug Resistance, Multiple; Dru | 2002 |
Therapeutic efficacy of chloroquine and sulfadoxine/pyrimethamine against Plasmodium falciparum infection in Somalia.
Topics: Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Evaluation; Drug | 2002 |
Resistance patterns of Plasmodium falciparum malaria to chloroquine in Kampala, Uganda.
Topics: Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; | 2002 |
Molecular surveillance of drug resistance through imported isolates of Plasmodium falciparum in Europe.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Codon; Dihydropteroate Synth | 2002 |
Drug-resistant Plasmodium falciparum infection in immigrants and non-immune travellers.
Topics: Adult; Africa; Animals; Antimalarials; Asia, Southeastern; Chloroquine; Drug Resistance; Emigration | 2002 |
Molecular epidemiology of malaria in Cameroon. XII. In vitro drug assays and molecular surveillance of chloroquine and proguanil resistance.
Topics: Animals; Antimalarials; Cameroon; Child; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; | 2002 |
Molecular epidemiology of malaria in Cameroon. XIII. Analysis of pfcrt mutations and in vitro chloroquine resistance.
Topics: Animals; Cameroon; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Proteins; Mem | 2002 |
Molecular epidemiology of malaria in Cameroon. XIV. Plasmodium falciparum chloroquine resistance transporter (PFCRT) gene sequences of isolates before and after chloroquine treatment.
Topics: Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Mal | 2002 |
Increasing antimalarial drug resistance in Uganda and revision of the national drug policy.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Databases, Factual; Evaluation Studies as Top | 2002 |
Diagnostic value of molecular markers in chloroquine-resistant falciparum malaria in Southern Mauritania.
Topics: Adult; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Female; Genet | 2002 |
Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes.
Topics: Animals; Anopheles; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; DNA, Protozoan; D | 2002 |
A molecular surveillance system for global patterns of drug resistance in imported malaria.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistan | 2003 |
In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Gabon; Humans; Inhibitory Concentration 50; Ma | 2003 |
Chloroquine or sulfadoxine-pyrimethamine for the treatment of uncomplicated, Plasmodium falciparum malaria during an epidemic in Central Java, Indonesia.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Disease Outbr | 2002 |
Evaluation of chloroquine as a potent anti-malarial drug: issues of public health policy and healthcare delivery in post-war Liberia.
Topics: Antimalarials; Chloroquine; Delivery of Health Care; Drug Resistance; Drug Utilization Review; Healt | 2003 |
[Changes in chloroquine resistance of Plasmodium falciparum in Hainan province].
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; China; Chloroquine; Drug Resistance; Humans; Ma | 1999 |
Assessment of therapeutic efficacy of chloroquine against falciparum malaria in an outbreak area in Xishuangbanna, Yunnan.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; China; Chloroquine; Female; Humans; | 2002 |
[Comparison of three approaches to prevent falciparum malaria in Chinese who worked in an African country with high endemicity of malaria].
Topics: Adult; Antimalarials; Chloroquine; Communicable Disease Control; Female; Humans; Malaria, Falciparum | 2001 |
Early treatment of childhood fevers with pre-packaged antimalarial drugs in the home reduces severe malaria morbidity in Burkina Faso.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Aspirin; Burkina Faso; Child, Preschool; Chl | 2003 |
[Therapeutic efficacy of chloroquine in the uncomplicated malaria due to Plasmodium falciparum in hospital patients in central Ivory Coast (1997-2000)].
Topics: Age Factors; Antimalarials; Child, Preschool; Chloroquine; Cote d'Ivoire; Drug Administration Schedu | 2002 |
In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe.
Topics: Animals; Antiprotozoal Agents; Chloroquine; Drug Resistance; Humans; Inhibitory Concentration 50; Ma | 2003 |
pfcrt and pfmdr1 mutations and chloroquine resistance in Plasmodium falciparum from São Tomé and Príncipe, West Africa.
Topics: Alleles; Animals; Antimalarials; Atlantic Islands; ATP-Binding Cassette Transporters; Chloroquine; D | 2002 |
Clinical efficacy of chloroquine in young children with uncomplicated falciparum malaria--a community-based study in rural Burkina Faso.
Topics: Antimalarials; Burkina Faso; Chloroquine; Cohort Studies; Drug Resistance; Female; Humans; Infant; M | 2003 |
Profile and evolution of the chemosusceptibility of falciparum malaria imported into France in 2000.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistan | 2002 |
In-vitro sensitivity of Plasmodium falciparum to chloroquine, halofantrine, mefloquine and quinine in Madagascar.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Hospitals, Publi | 2002 |
Drug-resistant malaria in Bangladesh: an in vitro assessment.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Bangladesh; Chloroquine; Drug Resistance; Female; | 2003 |
Association of Plasmodium falciparum chloroquine resistance transporter variant T76 with age-related plasma chloroquine levels.
Topics: Age Factors; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; DNA Primers; Drug Resista | 2003 |
Influence of chloroquine treatment and Plasmodium falciparum malaria infection on some enzymatic and non-enzymatic antioxidant defense indices in humans.
Topics: Adolescent; Adult; Animals; Antimalarials; Catalase; Ceruloplasmin; Chloroquine; Cholesterol; Erythr | 2003 |
In vitro susceptibility to a new antimalarial organometallic analogue, ferroquine, of Plasmodium falciparum isolates from the Haut-Ogooué region of Gabon.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Resistance; Ferrous Compounds; Gabon; Hum | 2003 |
The hospital- and field-based performances of the OptiMAL test, for malaria diagnosis and treatment monitoring in central India.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Combinations; False Negative Reactions; False Posit | 2003 |
Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in Niamey, Niger, in 2001.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Malaria, Falciparum | 2003 |
The treatment of Plasmodium falciparum-infected erythrocytes with chloroquine leads to accumulation of ferriprotoporphyrin IX bound to particular parasite proteins and to the inhibition of the parasite's 6-phosphogluconate dehydrogenase.
Topics: Animals; Antimalarials; Chloroquine; Erythrocyte Membrane; Erythrocytes; Glycolysis; Hemin; Humans; | 2003 |
[Iron supplementation associated with malaria prevention among pregnant women in Abidjan].
Topics: Adult; Analysis of Variance; Anemia, Iron-Deficiency; Antimalarials; Attitude of Health Personnel; C | 2003 |
Antiplasmodial activity of alkaloid extracts from Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC), two plants used in traditional medicine in Burkina Faso.
Topics: Alkaloids; Animals; Antimalarials; Asteraceae; Burkina Faso; Cell Line; Child; Child, Preschool; Chl | 2003 |
In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Humans | 2002 |
Parasitemia in children with Plasmodium falciparum malaria receiving chemoprophylaxis.
Topics: Adolescent; Age Distribution; Animals; Chemoprevention; Child; Child, Preschool; Chloroquine; Cohort | 2003 |
Prevalence of malaria in Aligarh.
Topics: Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; India; | 2002 |
The clinical and epidemiological features of childhood malaria in a moderately endemic area of Sri Lanka.
Topics: Administration, Oral; Antimalarials; Arthralgia; Case-Control Studies; Child; Child Welfare; Child, | 2002 |
Malaria in Austria 1990-2000.
Topics: Adolescent; Adult; Age Distribution; Animals; Austria; Chemoprevention; Child; Child, Preschool; Chl | 2003 |
Failure of a chloroquine chemoprophylaxis program to adequately prevent malaria during pregnancy in Koupéla District, Burkina Faso.
Topics: Adolescent; Adult; Animals; Antimalarials; Burkina Faso; Chemoprevention; Chloroquine; Cross-Section | 2003 |
Health seeking behavior by families of children suspected to have malaria in Kabale: Uganda.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Studies; Drug Combinat | 2002 |
[Malaria--case report].
Topics: Adult; Anti-Infective Agents; Antidiarrheals; Antimalarials; Chloroquine; Ciprofloxacin; Diarrhea; E | 2003 |
Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans; Mala | 2003 |
Prevalence of Plasmodium falciparum pfcrt polymorphisms and in vitro chloroquine sensitivity in Senegal.
Topics: Adolescent; Adult; Alleles; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; DNA, Proto | 2003 |
Metapopulation concepts applied to falciparum malaria and their impacts on the emergence and spread of chloroquine resistance.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Genetics, Population; Humans; Malaria, Falcipa | 2003 |
Monitoring the chloroquine sensitivity of Plasmodium vivax from Calcutta and Orissa, India.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Malaria, V | 2003 |
The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Drug | 2003 |
Surveillance of in vivo resistance of Plasmodium falciparum to antimalarial drugs from 1992 to 1999 in Malabo (Equatorial Guinea).
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Eq | 2003 |
Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal community.
Topics: Adolescent; Adult; Age Factors; Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroqu | 2003 |
Prevalence of the K76T mutation in the pfcrt gene of Plasmodium falciparum among chloroquine responders in India.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Chloroquine; DNA, Bacterial; Drug Resistance | 2003 |
[Imported malaria in 2000 in 2 northern Paris hospitals].
Topics: Africa; Antimalarials; Chemoprevention; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falc | 2003 |
Real-time PCR for chloroquine sensitivity assay and for pfmdr1-pfcrt single nucleotide polymorphisms in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Benzothiazoles; Chloroquine; Diamines; DN | 2003 |
Ineffectiveness of chloroquine antenatal prophylaxis in East of Democratic Republic of Congo (RDC).
Topics: Animals; Antimalarials; Chloroquine; Democratic Republic of the Congo; Drug Resistance; Female; Huma | 2003 |
New haplotypes of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene among chloroquine-resistant parasite isolates.
Topics: Animals; Antimalarials; Chloroquine; DNA Mutational Analysis; DNA, Protozoan; Drug Resistance; Haplo | 2003 |
Very high risk of therapeutic failure with chloroquine for uncomplicated Plasmodium falciparum and P. vivax malaria in Indonesian Papua.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Indonesia; Life Tabl | 2003 |
Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi.
Topics: Adolescent; Animals; Antimalarials; ATP-Binding Cassette Transporters; Child; Child, Preschool; Chlo | 2003 |
The mortality consequences of the continued use of chloroquine in Africa: experience in Siaya, western Kenya.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Infant, Newb | 2003 |
Multiple transporters associated with malaria parasite responses to chloroquine and quinine.
Topics: Animals; Antimalarials; Chloroquine; Databases, Nucleic Acid; Drug Resistance; Genes, Protozoan; Hum | 2003 |
Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum.
Topics: Adenosine Triphosphate; Animals; Antimalarials; Chloroquine; Drug Carriers; Drug Resistance; Humans; | 2003 |
[Chloroquine drug prophylaxis no longer prevents Plasmodium falciparum-induced fetal hypotrophy in Kinshasa].
Topics: Adolescent; Adult; Age Factors; Animals; Antimalarials; Chloroquine; Drug Resistance; Embryonic and | 2003 |
Effect of chloroquine on human immunodeficiency virus (HIV) vertical transmission.
Topics: Animals; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Cohort Studies; Female; F | 2003 |
Prevalence of Plasmodium falciparum infection in pregnant women in Gabon.
Topics: Adolescent; Adult; Age Factors; Animals; Chloroquine; Female; Fever; Gabon; Gravidity; Hemoglobin, S | 2003 |
Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria.
Topics: Acute Disease; Animals; Antimalarials; ATP-Binding Cassette Transporters; Child; Child, Preschool; C | 2003 |
Plasmodium falciparum gametocytaemia in Nigerian children: Peripheral immature gametocytaemia as an indicator of a poor response to chloroquine treatment, and its relationship to molecular determinants of chloroquine resistance.
Topics: Acute Disease; Administration, Oral; Adolescent; Animals; Antimalarials; ATP-Binding Cassette Transp | 2003 |
Asymptomatic, recrudescent, chloroquine-resistant Plasmodium falciparum infections in Nigerian children: clinical and parasitological characteristics and implications for the transmission of drug-resistant parasites.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Fe | 2003 |
Plasmodium falciparum: correlation of in vivo resistance to chloroquine and antifolates with genetic polymorphisms in isolates from the south of Lao PDR.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinat | 2003 |
A study of falciparum malaria in Liberia and its treatment with chloroquine.
Topics: Chloroquine; Humans; Liberia; Malaria; Malaria, Falciparum | 1952 |
Intensity of transmission and spread of gene mutations linked to chloroquine and sulphadoxine-pyrimethamine resistance in falciparum malaria.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance, Mu | 2003 |
The treatment of Plasmodium falciparum infection with chloroquine, with a note on infectivity to mosquitoes of primaquine- and pyrimethamine-treated cases.
Topics: Animals; Antimalarials; Chloroquine; Culicidae; Humans; Malaria, Falciparum; Plasmodium falciparum; | 1956 |
Short report: association between chloroquine and amodiaquine resistance and allelic variation in the Plasmodium falciparum multiple drug resistance 1 gene and the chloroquine resistance transporter gene in isolates from the upper Nile in southern Sudan.
Topics: Alleles; Amodiaquine; Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Drug R | 2003 |
Observations on two Plasmodium falciparum infections with an abnormal response to chloroquine.
Topics: Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum | 1961 |
[Resistance of P. falciparum to the action of chloroquine (preliminary note)].
Topics: Chloroquine; Humans; Malaria; Malaria, Falciparum | 1961 |
Chloroquine-resistant falciparum malaria in Malaya.
Topics: Animals; Chloroquine; Culicidae; Humans; Malaria; Malaria, Falciparum; Malaysia | 1963 |
CHLOROQUINE RESISTANT FALCIPARUM MALARIA IN MALAYA.
Topics: Animals; Chloroquine; Culicidae; Drug Resistance; Drug Resistance, Microbial; Humans; Malaria; Malar | 1963 |
DRUG-RESISTANT FALCIPARUM MALARIA FROM CAMBODIA AND MALAYA.
Topics: Animals; Cambodia; Chloroquine; Culicidae; Drug Resistance; Drug Resistance, Microbial; Humans; Mala | 1963 |
STUDIES IN THE ACQUISITION OF IMMUNITY OF PLASMODIUM FALCIPARUM INFECTIONS IN AFRICA.
Topics: Adolescent; Africa; Africa, Western; Allergy and Immunology; Child; Chloroquine; Humans; Infant; Mal | 1964 |
STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM THAILAND.
Topics: Amodiaquine; Antimalarials; Asia, Southeastern; Biomedical Research; Chloroquine; Drug Resistance; D | 1964 |
CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN MALAYA.
Topics: Animals; Chloroquine; Culicidae; Drug Resistance; Drug Resistance, Microbial; Humans; Malaria; Malar | 1963 |
CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN SOUTH-EAST ASIA, WITH A REPORT OF A CASE FROM THAILAND.
Topics: Asia, Southeastern; Chloroquine; Drug Resistance; Drug Resistance, Microbial; Humans; Malaria; Malar | 1964 |
STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM VIET-NAM.
Topics: Amodiaquine; Antimalarials; Biomedical Research; Chloroquine; Drug Therapy; Humans; Malaria; Malaria | 1964 |
GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND FALCIPARUM MALARIA.
Topics: Biomedical Research; Chloroquine; Drug Therapy; Glucosephosphate Dehydrogenase Deficiency; Glucoseph | 1965 |
The single dose treatment of falciparum malaria with nivaquine; a review of 164 cases treated at the District Hospital, Kuala Kangsar.
Topics: Chloroquine; Hospitals, District; Malaria; Malaria, Falciparum; Quinolines; Uricosuric Agents | 1955 |
Molecular epidemiology of malaria in Cameroon. XV. Experimental studies on serum substitutes and supplements and alternative culture media for in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum.
Topics: Amodiaquine; Animals; Antimalarials; Cameroon; Chloroquine; Culture Media; Humans; Malaria, Falcipar | 2003 |
Chloroquine-resistant Plasmodium falciparum malaria in Ilorin, Nigeria: prevalence and risk factors for treatment failure.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Fe | 2001 |
Sentinel posts for monitoring therapeutice efficacy of antimalarial drugs against Plasmodium falciparum infections in the Sudan.
Topics: Adolescent; Adult; Analysis of Variance; Animals; Antimalarials; Child; Child, Preschool; Chloroquin | 2001 |
Evaluation of a simple operational approach for monitoring resistance to antimalarial drugs in Peru.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Monitoring; Drug Resistance; Humans; Malaria, Fa | 2003 |
Autoimmune thrombocytopenia in malaria.
Topics: Antimalarials; Autoantibodies; Chloroquine; Erythrocyte Transfusion; Humans; Malaria, Cerebral; Mala | 2003 |
[Chloroquine resistant strains of Plasmodium falciparum in the Anopheles vector and use of antimalarials].
Topics: Adolescent; Adult; Aged; Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroquine; Dr | 1996 |
Two worlds of malaria.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Life Cycle St | 2003 |
Delayed onset of malaria--implications for chemoprophylaxis in travelers.
Topics: Antimalarials; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Israel; Malaria; Malaria, Fal | 2003 |
Application of a multi-faceted approach for the assessment of treatment response in falciparum malaria: a study from Malaysian Borneo.
Topics: Animals; Antimalarials; Borneo; Chloroquine; Drug Resistance, Multiple; Genes, MDR; Genes, Protozoan | 2003 |
pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines.
Topics: Alleles; Amino Acid Substitution; Amino Acids; Animals; Antimalarials; Calcium Channel Blockers; Chl | 2003 |
[Placental infection by Plasmodium falciparum in an urban area of Senegal].
Topics: Adolescent; Adult; Animals; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Middl | 2003 |
Diagnosis and treatment of malaria in children.
Topics: Animals; Antimalarials; Atovaquone; Child; Chloroquine; Drug Combinations; Humans; Malaria; Malaria, | 2003 |
Amodiaquine treatment of uncomplicated malaria in children, in an area of chloroquine-resistant Plasmodium falciparum in north-central Nigeria.
Topics: Amodiaquine; Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Infant; | 2003 |
[Factors affecting the in vitro microtest for drug sensitivity of Plasmodium falciparum].
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Blood; Chloroquine; Humans; Malaria, Falciparum; N | 2003 |
Relationship between the Pfcrt T76 and the Pfmdr-1 Y86 mutations in Plasmodium falciparum and in vitro/in vivo chloroquine resistance in Burkina Faso, West Africa.
Topics: Adolescent; Animals; Antimalarials; Burkina Faso; Child; Child, Preschool; Chloroquine; Drug Resista | 2003 |
Diagnosis of malaria aided by polymerase chain reaction in two cases with low-level parasitaemia.
Topics: Adult; Animals; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Plasm | 2003 |
Multi-drug resistant Plasmodium falciparum malaria in Assam, India: timing of recurrence and anti-malarial drug concentrations in whole blood.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance, Multiple; Female; Hu | 2003 |
Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; H | 2003 |
Malaria status in Al-Hodeidah Governorate, Republic of Yemen. Part II: Human factors causing the persistence of chloroquine resistant P. falciparum local strain.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Education | 2003 |
Changes in Plasmodium falciparum gametocytaemia in children with chloroquine-sensitive asexual infections.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Kinet | 2003 |
A cost-effectiveness analysis of three antimalarial treatments for acute, uncomplicated Plasmodium falciparum malaria in Mumbai, India.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Clinical Trials | 2003 |
[Misunderstood neurological side effects of amodiaquine: apropos of 35 cases in children at Central University Hospital of Yopougon at Abidjan, Côte d' Ivoire].
Topics: Adolescent; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Cote d'Ivoire; Drug Re | 2003 |
Stable SNPs in malaria antigen genes in isolated populations.
Topics: Alleles; Amino Acid Sequence; Animals; Antigens, Protozoan; Antimalarials; Chloroquine; Drug Resista | 2004 |
The pharmacodynamic study of a potent new antimalarial (MC1).
Topics: Animals; Antimalarials; Blood Glucose; Cells, Cultured; Chloroquine; Humans; Malaria, Falciparum; Ma | 2004 |
Therapeutic efficacies of antimalarial drugs in the treatment of uncomplicated, Plasmodium falciparum malaria in Assam, north-eastern India.
Topics: Adolescent; Adult; Aged; Animals; Anti-Infective Agents; Antimalarials; Artemisinins; Child; Child, | 2003 |
Chloroquine efficacy in the treatment of uncomplicated malaria at three sentinel sites in northern Togo.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Infant; Mala | 2003 |
Double-drug development against antioxidant enzymes from Plasmodium falciparum.
Topics: Animals; Antimalarials; Antioxidants; Chloroquine; Drug Resistance; Enzyme Inhibitors; Erythrocytes; | 2003 |
Malaria status in Al-Hodeidah Governorate, Yemen: malariometric parasitic survey & chloroquine resistance P. falciparum local strain.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Section | 2003 |
Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria.
Topics: Animals; Antigens, Protozoan; Antimalarials; Child; Child, Preschool; Chloroquine; DNA, Protozoan; D | 2004 |
Efficacy of arteether in chloroquine resistant falciparum malaria in eastern India.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Female; Humans; India; Malaria, | 2004 |
Detection by real-time PCR of the Pfcrt T76 mutation, a molecular marker of chloroquine-resistant Plasmodium falciparum strains.
Topics: Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Genetic Markers; Humans; Malar | 2004 |
Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea.
Topics: Aminoquinolines; Amodiaquine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlo | 2004 |
Widespread occurrence of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene haplotype SVMNT in P. falciparum malaria in India.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Drug Resistance; Hapl | 2004 |
Evolution of drug-resistance genes in Plasmodium falciparum in an area of seasonal malaria transmission in Eastern Sudan.
Topics: Alleles; Animals; Antimalarials; Chloroquine; Cross-Sectional Studies; DNA, Protozoan; Drug Combinat | 2004 |
Malaria during pregnancy in a reference centre from the Brazilian Amazon: unexpected increase in the frequency of Plasmodium falciparum infections.
Topics: Adolescent; Adult; Antimalarials; Brazil; Child; Chloroquine; Cross-Sectional Studies; Female; Human | 2004 |
Monitoring antimalarial drug efficacy.
Topics: Animals; Antimalarials; Chloroquine; Drug Monitoring; Drug Resistance; Humans; Laos; Malaria, Falcip | 2004 |
Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; DNA Damage; DNA Repair; Drug Resistance; Drug Res | 2004 |
In vitro susceptibility of Plasmodium falciparum isolates to chloroquine and mefloquine in southeastern Mindanao Island, the Philippines.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Female; Humans; I | 2003 |
Comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for uncomplicated Plasmodium falciparum malaria and impact on gametocyte carriage rates in the East Nusatenggara province of Indonesia.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Drug Th | 2004 |
Oleanene constituents of Lantana cujabensis.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Lantana; Malaria, Falciparum; Oleanolic Acid; | 2004 |
Anti-plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Kenya; Mala | 2004 |
Studies on medicinal plants of Ivory Coast: investigation of Sida acuta for in vitro antiplasmodial activities and identification of an active constituent.
Topics: Animals; Antimalarials; Chloroquine; Cote d'Ivoire; Drug Resistance; Inhibitory Concentration 50; Ma | 2004 |
Drug resistance in Plasmodium falciparum from the Chittagong Hill Tracts, Bangladesh.
Topics: Adolescent; Adult; Animals; Antimalarials; ATP-Binding Cassette Transporters; Bangladesh; Child; Chi | 2004 |
Dihydroethanoanthracene derivatives as in vitro malarial chloroquine resistance reversal agents.
Topics: Animals; Anthracenes; Antimalarials; Bridged-Ring Compounds; Chloroquine; Drug Resistance; Humans; M | 2004 |
pfcrt Polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin.
Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Brazil; Chloroquine; DNA, Protozoan; Drug | 2004 |
The in-vitro antimalarial activity of ferrochloroquine, measured against Cambodian isolates of Plasmodium falciparum.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Cambodia; Chloroquine; Drug Resistance; Humans; Ma | 2004 |
Acute gluteal abscess due to chloroquine injection in Sudanese pregnant woman.
Topics: Abscess; Adult; Antimalarials; Buttocks; Chloroquine; Drainage; Female; Humans; Injections, Intramus | 2004 |
[Efficacy of chloroquine in treatment of non-complicated malaria with Plasmodium falciparum in children at the San Pedro dispensary in Côte d'Ivoire].
Topics: Administration, Oral; Adolescent; Age Factors; Ambulatory Care Facilities; Antimalarials; Child; Chi | 2004 |
Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones.
Topics: Animals; Antimalarials; Chloroquine; Cross-Sectional Studies; Disease Outbreaks; DNA, Protozoan; Dru | 2004 |
The PfCRT (K76T) point mutation favours clone multiplicity and disease severity in Plasmodium falciparum infection.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Ma | 2004 |
Intercontinental spread of pyrimethamine-resistant malaria.
Topics: Africa; Alleles; Animals; Antimalarials; Asia, Southeastern; Chloroquine; Drug Resistance; Drug Ther | 2004 |
Chloroquine resistant falciparum malaria among security forces personnel in the Northern Province of Sri Lanka.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Male; Military Pe | 2004 |
Pfcrt K76T mutation and its associations in imported Plasmodium falciparum malaria cases.
Topics: Adult; Amino Acid Substitution; Animals; Antimalarials; Black People; Chloroquine; Codon; Drug Resis | 2004 |
Single intravenous injections of chloroquine in the treatment of falciparum malaria: toxic and immediate therapeutic effects in 110 cases.
Topics: Chloroquine; Humans; Injections, Intravenous; Malaria; Malaria, Falciparum | 1950 |
Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro.
Topics: Animals; Antimalarials; Base Sequence; Biological Transport, Active; Cambodia; Chloroquine; DNA, Com | 2004 |
In vitro and in vivo antimalarial studies of Striga hermonthica and Tapinanthus sessilifolius extracts.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; In Vi | 2004 |
Serum levels of soluble urokinase plasminogen activator receptor is associated with parasitemia in children with acute Plasmodium falciparum malaria infection.
Topics: Acetaminophen; Acute Disease; Amoxicillin; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; | 2004 |
Association of house spraying with suppressed levels of drug resistance in Zimbabwe.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Cross-Sectional Studies; Dru | 2004 |
Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antimalarials; Burkina Faso; Caregivers; Child, Preschool; | 2004 |
In-vitro interaction of tafenoquine and chloroquine in Plasmodium falciparum from northwestern Thailand.
Topics: Adolescent; Adult; Aminoquinolines; Animals; Antimalarials; Cell Proliferation; Chloroquine; Dose-Re | 2003 |
In-vitro response of Plasmodium falciparum to the main alkaloids of Cinchona in northwestern Thailand.
Topics: Adolescent; Adult; Animals; Antimalarials; Cell Proliferation; Chloroquine; Cinchona Alkaloids; Dose | 2003 |
Transporter of a malaria catastrophe.
Topics: Amantadine; Animals; Chloroquine; Drug Resistance; Global Health; Humans; Malaria, Falciparum; Membr | 2004 |
Polyphosphate content and fine structure of acidocalcisomes of Plasmodium falciparum.
Topics: Animals; Antimalarials; Calcium; Chloroquine; Electron Probe Microanalysis; Erythrocytes; Malaria, F | 2004 |
[Acute malaria in an Israeli tourist to Kenya].
Topics: Acidosis; Adult; Chloroquine; Drug Therapy, Combination; Humans; Malaria, Falciparum; Male; Mefloqui | 1999 |
Polymorphism in plasmodium falciparum drug transporter proteins and reversal of in vitro chloroquine resistance by a 9,10-dihydroethanoanthracene derivative.
Topics: Animals; Anthracenes; Antimalarials; Carrier Proteins; Chloroquine; DNA, Protozoan; Drug Resistance; | 2004 |
In vitro monitoring of Plasmodium falciparum susceptibility to artesunate, mefloquine, quinine and chloroquine in Cambodia: 2001-2002.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Cambodia; Chloroquine; Drug Resistance; Humans; In | 2005 |
Prevalence of pfcrt mutations in Congolese and Malawian Plasmodium falciparum isolates as determined by a new Taqman assay.
Topics: Animals; Child, Preschool; Chloroquine; Democratic Republic of the Congo; DNA, Protozoan; Drug Resis | 2005 |
Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa.
Topics: Adult; Africa South of the Sahara; Africa, Western; Antimalarials; Case-Control Studies; Chloroquine | 2005 |
[Revaluation of chloroquine therapeutic efficacy on children with uncomplicated Plasmodium falciparum malaria in eastern Ivory Coast (1999-2002)].
Topics: Antimalarials; Child, Preschool; Chloroquine; Cote d'Ivoire; Drug Resistance, Microbial; Female; Hum | 2004 |
Plasmodium falciparum resistant to chloroquine and to pyrimethamine in Comoros.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Comoros; DNA, Protozoan; Drug Resistan | 2004 |
Influence of chemotherapy on the Plasmodium gametocyte sex ratio of mice and humans.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Female; Humans; Inf | 2004 |
Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda.
Topics: Alleles; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Dihydropteroate | 2004 |
[Drug susceptibility of Plasmodium falciparum from polyclonal isolates].
Topics: Africa, Western; Alleles; Animals; Antigens, Protozoan; Antimalarials; Cells, Cultured; Chloroquine; | 2004 |
The PfCRT (K76T) point mutation in Plasmodium falciparum, and its usefulness for monitoring chloroquine resistance.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Haplotypes; | 2004 |
Chloroquine resistant malaria in neonates.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Infant, Newborn; Malaria, Falciparum; Malaria, | 2005 |
[Imported cerebral malaria].
Topics: Adult; Antimalarials; Chloroquine; Drug Resistance; Female; France; Humans; Malaria, Cerebral; Malar | 2005 |
The development of the antimalarial drugs with new type of chemical structure--qinghaosu and dihydroqinghaosu.
Topics: Animals; Antimalarials; Artemisia annua; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; | 2004 |
Chloroquine resistance and Plasmodium falciparum in Punjab, Pakistan during 2000-2001.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cluster Analysis; Drug Res | 2004 |
Glutathione-S-transferases from chloroquine-resistant and -sensitive strains of Plasmodium falciparum: what are their differences?
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Glutathione Transferase; Isoenzymes; Malaria, | 2004 |
Serious psychiatric symptoms after chloroquine treatment following experimental malaria infection.
Topics: Adult; Antimalarials; Chloroquine; Female; Human Experimentation; Humans; Malaria, Falciparum; Psych | 2005 |
A simple, high-throughput method to detect Plasmodium falciparum single nucleotide polymorphisms in the dihydrofolate reductase, dihydropteroate synthase, and P. falciparum chloroquine resistance transporter genes using polymerase chain reaction- and enzy
Topics: Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; DNA Primers; DNA, Protozoan; Drug Com | 2005 |
Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum.
Topics: Alkaloids; Animals; Benzylisoquinolines; Chloroquine; Disease Models, Animal; Dose-Response Relation | 2005 |
High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal.
Topics: Adult; Animals; Antimalarials; Chemoprevention; Chloroquine; DNA, Protozoan; Drug Resistance; Female | 2005 |
Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China.
Topics: Animals; Antimalarials; Base Sequence; China; Chloroquine; Codon; DNA Primers; Drug Resistance; Gene | 2005 |
Origin and dissemination of chloroquine-resistant Plasmodium falciparum with mutant pfcrt alleles in the Philippines.
Topics: Alleles; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane | 2005 |
Evaluation of chloroquine (CQ) and sulphadoxine/pyrimethamine (SP) therapy in uncomplicated falciparum malaria in Indo-Myanmar border areas.
Topics: Adolescent; Adult; Age Distribution; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; D | 2005 |
Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.
Topics: Amodiaquine; Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistan | 2005 |
Assessment of clinical course and outcome of Plasmodium falciparum malaria in Angola diagnosed by microscopic and molecular methods.
Topics: Adolescent; Adult; Angola; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; DNA Primers | 2004 |
Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?
Topics: Animals; Antimalarials; Artemisinins; Artesunate; ATP-Binding Cassette Transporters; Chloroquine; Dr | 2005 |
Plasmodium falciparum: higher incidence of molecular resistance markers for sulphadoxine than for pyrimethamine in Kasangati, Uganda.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Codon; Dihydroptero | 2005 |
Diagnostic and prognostic utility of an inexpensive rapid on site malaria diagnostic test (ParaHIT f) among ethnic tribal population in areas of high, low and no transmission in central India.
Topics: Adult; Antimalarials; Child; Chloroquine; Ethnicity; Female; Humans; India; Infant; Malaria, Falcipa | 2005 |
Plasmodium falciparum malaria in Nigerian children during high and low transmission seasons: gametocyte carriage and response to oral chloroquine.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Gametogenesis; Humans; Infant; | 2005 |
Isradipine--a calcium channel blocker--does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum.
Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Drug Resistance; Drug Synergism; Huma | 2005 |
Use of a locked-nucleic-acid oligomer in the clamped-probe assay for detection of a minority Pfcrt K76T mutant population of Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Codon; DNA, Protozoan; Drug Resistance; Humans; Malaria, Falcip | 2005 |
The roles of the pfcrt 76T and pfmdr1 86Y mutations, immunity and the initial level of parasitaemia, in predicting the outcome of chloroquine treatment in two areas with different transmission intensities.
Topics: Adult; Animals; Antimalarials; ATP-Binding Cassette Transporters; Child; Child, Preschool; Chloroqui | 2005 |
Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil.
Topics: Adverse Drug Reaction Reporting Systems; Antimalarials; Chemical and Drug Induced Liver Injury; Chlo | 2005 |
Rapid increase in resistance of Plasmodium falciparum to chloroquine-Fansidar in Uganda and the potential of amodiaquine-Fansidar as a better alternative.
Topics: Amodiaquine; Animals; Antimalarials; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug C | 2005 |
[Fluctuation in the resistance of Plasmodium falciparum to chloroquine in China].
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Hu | 2005 |
Molecular epidemiology of drug resistance markers of Plasmodium falciparum malaria in Thailand.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Biomarkers; Chloroquine; Drug Resistance; | 2005 |
Effectiveness of antimalarial drugs.
Topics: Adult; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combinat | 2005 |
In vitro antimalarial drug susceptibility in Thai border areas from 1998-2003.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; Inhibitory Concentration | 2005 |
Malaria transmission intensity and the rate of spread of chloroquine resistant Plasmodium falciparum: Why have theoretical models generated conflicting results?
Topics: Alleles; Animals; Antimalarials; Chloroquine; Codon; Drug Resistance; Evolution, Molecular; Gene Fre | 2006 |
Antimalarial compounds from Kniphofia foliosa roots.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; KB Cells; Liliaceae; Malaria, Falcipar | 2005 |
[Malaria in childhood and G6PD deficiency. Report of three cases].
Topics: Adolescent; Antimalarials; Black People; Blood Transfusion; Child; Chloroquine; Comoros; Emergency T | 1978 |
Rapid immunochromatography-based detection of mixed-species malaria infection in Pakistan.
Topics: Adult; Animals; Antigens, Protozoan; Antimalarials; Azure Stains; Chloroquine; Chromatography; Drug | 2005 |
Economic evaluation of a policy change from single-agent treatment for suspected malaria to artesunate-amodiaquine for microscopically confirmed uncomplicated falciparum malaria in the Oussouye District of south-western Senegal.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Ch | 2005 |
Prevalence of pfcrt point mutations and level of chloroquine resistance in Plasmodium falciparum isolates from Africa.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Democratic Republic | 2006 |
Predictors of the failure of treatment with chloroquine in children with acute, uncomplicated, Plasmodium falciparum malaria, in an area with high and increasing incidences of chloroquine resistance.
Topics: Acute Disease; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Endemic Disease | 2005 |
High frequency of Plasmodium falciparum PfCRT K76T and PfpghN86Y in patients clearing infection after chloroquine treatment in the Sudan.
Topics: Adolescent; Adult; Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2006 |
Detection of Plasmodium falciparum in pregnancy by laser desorption mass spectrometry.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Female; Genotype; Hu | 2005 |
Epidemiology of drug-resistant malaria in Republic of Congo: using molecular evidence for monitoring antimalarial drug resistance combined with assessment of antimalarial drug use.
Topics: Antimalarials; Biomarkers; Child, Preschool; Chloroquine; Congo; Dihydropteroate Synthase; Drug Comb | 2005 |
Adoption of the new antimalarial drug policy in Tanzania--a cross-sectional study in the community.
Topics: Antimalarials; Artemisinins; Child, Preschool; Chloroquine; Cross-Sectional Studies; Drug Combinatio | 2005 |
Carriage of chloroquine-resistant parasites and delay of effective treatment increase the risk of severe malaria in Gambian children.
Topics: Alleles; Anemia; Animals; ATP-Binding Cassette Transporters; Case-Control Studies; Child; Child, Pre | 2005 |
Imported malaria in pregnancy: a retrospective study of 18 cases in Marseilles, France.
Topics: Adolescent; Adult; Anemia; Antimalarials; Chloroquine; Female; France; Humans; Hypoglycemia; Malaria | 2005 |
Research influence on antimalarial drug policy change in Tanzania: case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug.
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Health Policy; Humans; Mala | 2005 |
Semisynthetic 15-O-acyl- and 1,15-di-O-acyleurycomanones from Eurycoma longifolia as potential antimalarials.
Topics: Animals; Antimalarials; Artemia; Chloroquine; Drug Resistance; Eurycoma; Humans; Malaria, Falciparum | 2005 |
Increased density but not prevalence of gametocytes following drug treatment of Plasmodium falciparum.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; H | 2006 |
Drug resistance and genetic diversity of Plasmodium falciparum parasites from suriname.
Topics: Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; Drug Resistance; | 2005 |
Insight into the early spread of chloroquine-resistant Plasmodium falciparum infections in Papua New Guinea.
Topics: Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Female; Genes, MDR; Humans; Ma | 2005 |
An efficient PCR--SSCP-based method for detection of a chloroquine resistance marker in the PfCRT gene of Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Genetic Markers; Humans; India | 2006 |
Chloroquine-treatment failure in northern Ghana: roles of pfcrt T76 and pfmdr1 Y86.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Child; Child, Preschool; Chloroquine; Dru | 2005 |
Efficacy of chloroquine, sulfadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria among children under five in Bongor and Koumra, Chad.
Topics: Amodiaquine; Animals; Chad; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Drug | 2006 |
[The point mutations in Pfcrt and Pfmdr1 genes in Plasmodium falciparum isolated from Hainan Province].
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Chloroquine; Codon; Drug Resistance; Humans; | 2005 |
Efficacy of chloroquine-proguanil malaria prophylaxis in a non-immune population in Bangui, Central African Republic: a case-control study.
Topics: Adolescent; Adult; Aged; Antimalarials; Case-Control Studies; Central African Republic; Child; Child | 2006 |
Malagashanine potentiates chloroquine antimalarial activity in drug resistant Plasmodium malaria by modifying both its efflux and influx.
Topics: Alkaloids; Animals; Antimalarials; Chloroquine; Culture Media; Drug Resistance; Drug Synergism; Eryt | 2006 |
In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chlor | 2006 |
Falciparum malaria in the north of Laos: the occurrence and implications of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene haplotype SVMNT.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Section | 2005 |
Chloroquine-induced bilateral ptosis.
Topics: Antimalarials; Blepharoptosis; Child, Preschool; Chloroquine; Humans; Malaria, Falciparum; Male | 2006 |
CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Age Factors; Animals; Antimalarials; Body Temperature; CD4-Positive T-Lymphocytes | 2006 |
Monitoring of the therapeutic efficacy of chloroquine for the treatment of uncomplicated, Plasmodium falciparum malaria in Iran.
Topics: Adult; Antimalarials; Chloroquine; Female; Humans; Iran; Malaria, Falciparum; Male; Sentinel Surveil | 2006 |
First evidence of pfcrt mutant Plasmodium falciparum in Madagascar.
Topics: Animals; Antimalarials; Chloroquine; Codon; Drug Resistance; Female; Humans; Madagascar; Malaria, Fa | 2006 |
Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Membrane P | 2006 |
Parvovirus B19 co-infection with falciparum malaria: a cause of severe anemia.
Topics: Antibodies, Viral; Antimalarials; Bone Marrow; Child; Chloroquine; Erythrocyte Transfusion; Humans; | 2005 |
Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Bangui, Central African Republic.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Central African Rep | 2006 |
The costs of changing national policy: lessons from malaria treatment policy guidelines in Tanzania.
Topics: Amodiaquine; Antimalarials; Chloroquine; Clinical Protocols; Drug Combinations; Health Care Costs; H | 2006 |
Prevention of malaria during pregnancy in West Africa: policy change and the power of subregional action.
Topics: Africa, Western; Antimalarials; Chloroquine; Communication Barriers; Drug Combinations; Drug Resista | 2006 |
Lack of association between putative transporter gene polymorphisms in Plasmodium falciparum and chloroquine resistance in imported malaria isolates from Africa.
Topics: Africa; Animals; Antimalarials; Carrier Proteins; Chloroquine; Drug Resistance; France; Genotype; Hu | 2006 |
Chloroquine and primaquine: combining old drugs as a new weapon against falciparum malaria?
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Fa | 2006 |
Progressive increase in point mutations associated with chloroquine resistance in Plasmodium falciparum isolates from India.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Communicable Disease Control | 2006 |
Epidemiology of malaria in New Halfa, an irrigated area in eastern Sudan.
Topics: Adolescent; Adult; Age Distribution; Agriculture; Antimalarials; Child; Child, Preschool; Chloroquin | 2005 |
[Malaria: a medical and economic problem].
Topics: Anti-Infective Agents; Antimalarials; Artemisinins; Atovaquone; Chloroquine; Drug Combinations; Drug | 2006 |
Role of pfmdr1 mutations on chloroquine resistance in Plasmodium falciparum isolates with pfcrt K76T from Papua New Guinea.
Topics: Adolescent; Animals; Antimalarials; ATP-Binding Cassette Transporters; Child; Child, Preschool; Chlo | 2006 |
Immunoglobulin G antibodies to merozoite surface antigens are associated with recovery from chloroquine-resistant Plasmodium falciparum in Gambian children.
Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Child; Child, Preschool; Chloroq | 2006 |
Epidemiological characterization of Plasmodium falciparum in the Republic of Cabo Verde: implications for potential large-scale re-emergence of malaria.
Topics: Animals; Antibodies, Protozoan; Antimalarials; Carrier State; Chloroquine; Communicable Diseases, Em | 2006 |
Invasion of Africa by a single pfcrt allele of South East Asian type.
Topics: Africa; Alleles; Animals; Antimalarials; Base Sequence; Cambodia; Chloroquine; DNA, Protozoan; Drug | 2006 |
The efficacy of sulfadoxine-pyrimethamine alone and in combination with chloroquine for malaria treatment in rural Eastern Sudan: the interrelation between resistance, age and gametocytogenesis.
Topics: Adolescent; Adult; Age Distribution; Antimalarials; Child; Chloroquine; Cohort Studies; Drug Combina | 2006 |
Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Disease-Free Surviv | 2006 |
Efficacy of chloroquine chemoprophylaxis for Plasmodium falciparum in Dindori District, Madhya Pradesh.
Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Humans; India; Malaria, Falciparum; Male; Plas | 2006 |
Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis.
Topics: Animals; Antimalarials; Apoptosis; Atovaquone; Cells, Cultured; Chloroquine; DNA Fragmentation; DNA, | 2006 |
Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania.
Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistan | 2006 |
Plasmodium falciparum chloroquine-resistance transporter gene detection in imported Plasmodium falciparum malaria cases.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Proteins | 2006 |
Chloroquine-resistant Plasmodium falciparum local strain in Taiz Governorate, Republic of Yemen.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Stu | 2006 |
Mefloquine-induced mania in a 22-year-old Chinese man.
Topics: Acute Disease; Adult; Animals; Antimalarials; Bipolar Disorder; Chloroquine; Contraindications; Huma | 2006 |
Therapeutic efficacy of sulphadoxine-pyrimethamine and chloroquine for the treatment of uncomplicated malaria in pregnancy in Burkina Faso.
Topics: Adolescent; Adult; Burkina Faso; Chloroquine; Contraindications; Drug Combinations; Female; Follow-U | 2006 |
High prevalence of drug-resistance mutations in Plasmodium falciparum and Plasmodium vivax in southern Ethiopia.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; | 2006 |
Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria.
Topics: Animals; Antimalarials; Child; Chloroquine; Chromosome Mapping; Drug Resistance; Humans; Linkage Dis | 2006 |
From chloroquine to artemisinin-based combination therapy: the Sudanese experience.
Topics: Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Drug Therapy, C | 2006 |
[Knowledge and practice among health workers from the Thiès region with regard to new malaria treatment policies].
Topics: Amodiaquine; Antimalarials; Chloroquine; Clinical Competence; Community Health Services; Drug Combin | 2006 |
Flashback to the 1960s: utility of archived sera to explore the origin and evolution of Plasmodium falciparum chloroquine resistance in the Pacific.
Topics: Amino Acid Sequence; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Evolution | 2006 |
[Successful management of malaria tropica with 50% parasitaemia].
Topics: Animals; Antimalarials; Chloroquine; Female; Germany; Humans; Kenya; Liver Function Tests; Malaria, | 2006 |
Paleoparasite populations from archived sera: insights into chloroquine drug resistance in Papua New Guinea.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Drug Resistance; Human | 2006 |
Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antimalarials; Child, Preschool; Chloroquine; Cyto | 2006 |
Molecular epidemiology of malaria in Cameroon. XXI. Baseline therapeutic efficacy of chloroquine, amodiaquine, and sulfadoxine-pyrimethamine monotherapies in children before national drug policy change.
Topics: Amodiaquine; Antimalarials; Cameroon; Child; Chloroquine; Drug Combinations; Health Policy; Humans; | 2006 |
Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Coloring Agents; Drug Resistance; Malaria, Fal | 2006 |
Additive effects of ciprofloxacin on the in-vitro activity of chloroquine against a clinical isolate of Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Ciprofloxacin; Drug Synergism; Drug Therapy, Combination; Malar | 2006 |
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 1. Quantification of hemozoin development for drug sensitive versus resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Hemeproteins; Humans; Image Proc | 2006 |
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Fluorescent Dyes; Humans; Hydrog | 2006 |
[Molecular epidemiology of imported malaria in Italy: the use of genetic markers and in vitro sensitivity test in a study of chloroquine resistance in Plasmodium falciparum].
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Em | 2006 |
Therapeutic efficacy of quinine plus sulfadoxine-pyremethamine for the treatment of uncomplicated falciparum malaria in Bangladesh.
Topics: Adolescent; Adult; Animals; Antimalarials; Bangladesh; Chloroquine; Drug Combinations; Drug Resistan | 2006 |
Vangueria infausta root bark: in vivo and in vitro antiplasmodial activity.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Malaria; Malaria, Falciparum; Mice; Mice, Inbr | 2006 |
Fluoxetine potentiates chloroquine and mefloquine effect on multidrug-resistant Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Drug Resistance, Multiple; Drug Synergism; Ery | 2006 |
Decreased availability of antimalarials in the private sector following the policy change from chloroquine to sulphadoxine-pyrimethamine in the Kilombero Valley, Tanzania.
Topics: Analgesics, Non-Narcotic; Antimalarials; Chloroquine; Drug Combinations; Health Policy; Humans; Mala | 2006 |
A multiplex ligase detection reaction-fluorescent microsphere assay for simultaneous detection of single nucleotide polymorphisms associated with Plasmodium falciparum drug resistance.
Topics: Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; Drug Combinations; Drug Resistance; F | 2007 |
Molecular epidemiology of malaria in Cameroon. XXIII. Experimental studies on serum substitutes and alternative culture media for in vitro drug sensitivity assays using clinical isolates of Plasmodium falciparum.
Topics: Animals; Cameroon; Chloroquine; Culture Media; Malaria, Falciparum; Molecular Epidemiology; Parasiti | 2006 |
Consumers stated and revealed preferences for community health workers and other strategies for the provision of timely and appropriate treatment of malaria in southeast Nigeria.
Topics: Adult; Animals; Antimalarials; Chloroquine; Community Health Services; Community Health Workers; Con | 2006 |
Mutations in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance genes, and treatment outcomes in Ghanaian children with uncomplicated malaria.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Chi-Square Distribution; Child, Preschool | 2007 |
In vitro activity of ferroquine (SAR97193) is independent of chloroquine resistance in Plasmodium falciparum.
Topics: Aminoquinolines; Animals; Antimalarials; Blood; Chloroquine; Drug Evaluation, Preclinical; Drug Resi | 2006 |
[A plasmodium alciparum malaria case originated from Mozambique: clues for the diagnosis and therapy].
Topics: Animals; Antimalarials; Canada; Chloroquine; Doxycycline; Drug Resistance; Erythrocytes; Humans; Mal | 2006 |
Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Fe | 2007 |
Evolutionary paradigm of chloroquine-resistant malaria in India.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Evolution, Molecular; Haplotypes; Humans; Indi | 2007 |
Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children.
Topics: Acute Disease; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Chlorpheni | 2006 |
Sustained use of insecticide-treated curtains is not associated with greater circulation of drug-resistant malaria parasites, or with higher risk of treatment failure among children with uncomplicated malaria in Burkina Faso.
Topics: Animals; Antimalarials; Bedding and Linens; Burkina Faso; Child, Preschool; Chloroquine; Cross-Secti | 2007 |
In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloro | 2007 |
Chloroquine-resistant malaria in Malawi.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malari | 2007 |
Chloroquine-resistant malaria in Malawi.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Combinations; Drug Resis | 2007 |
Chloroquine-resistant malaria in Malawi.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Genetics, Population; Humans; Malaria, | 2007 |
In vitro antiplasmodial activity and cytotoxicity of newly synthesized N-alkyl and N-benzyl-1,10-phenanthroline derivatives.
Topics: Animals; Cell Survival; Chelating Agents; Chlorocebus aethiops; Chloroquine; Cholinesterase Inhibito | 2006 |
Diagnosis and treatment of malaria in peripheral health facilities in Uganda: findings from an area of low transmission in south-western Uganda.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Animals; Child; Child, Presc | 2007 |
Antimalarial activity of sera from subjects taking HIV protease inhibitors.
Topics: Animals; Antimalarials; Antiretroviral Therapy, Highly Active; Chloroquine; Drug Synergism; HIV Infe | 2007 |
Rapid detection of Pfcrt and Pfmdr1 mutations in Plasmodium falciparum isolates by FRET and in vivo response to chloroquine among children from Osogbo, Nigeria.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Fluorescence | 2007 |
Pfcrt haplotypes and in-vivo chloroquine response in Sundergarh district, Orissa, India.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Haplotypes; Humans; India; I | 2007 |
Influence of oxygen on asexual blood cycle and susceptibility of Plasmodium falciparum to chloroquine: requirement of a standardized in vitro assay.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Erythrocytes | 2007 |
Diagnosis and management of malaria by rural community health providers in the Lao People's Democratic Republic (Laos).
Topics: Administration, Oral; Adult; Antimalarials; Child; Chloroquine; Clinical Competence; Community Healt | 2007 |
Chloroquine resistant P. falciparum prevalence is low and unchanged between 1990 and 2005 in Guinea-Bissau: an effect of high chloroquine dosage?
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Guinea-Bissau; Humans; Malaria, Falciparum; Pl | 2007 |
High residual chloroquine blood levels in African children with severe malaria seeking healthcare.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Drug | 2007 |
Chloroquine-resistant Plasmodium falciparum infections among UK travellers returning with malaria after chloroquine prophylaxis.
Topics: Alleles; Animals; Chloroquine; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Membrane Tran | 2007 |
Detection of in-vivo chloroquine resistance in Plasmodium falciparum from Rameswaram Island, a pilgrim centre in southern India.
Topics: Adolescent; Adult; Animals; Antigens, Protozoan; Antimalarials; Child; Child, Preschool; Chloroquine | 2007 |
Molecular surveillance for drug-resistant Plasmodiumfalciparum malaria in Malawi.
Topics: Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; DNA, Protozoan; Drug Combinations; Dr | 2007 |
High prevalence of molecular markers for resistance to chloroquine and pyrimethamine in Plasmodium falciparum from Zimbabwe.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Combinations; Drug Resi | 2007 |
The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Chloroquine; Drug R | 2007 |
Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Humans; Inhibitor | 2007 |
Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana.
Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Artemisinins; Child; Chloroquine; Drug | 2007 |
Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo.
Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Chlorpheniram | 2007 |
Antiplasmodial activity and cytotoxicity of Albertisia delagoensis.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Malaria, Falciparum; Menispermaceae; Parasitic | 2007 |
Detection of drug resistance markers for chloroquine and pyrimethamine-sulfadoxine in Jazan area, Saudi Arabia using PCR and restriction digestion.
Topics: Animals; Antimalarials; Biomarkers; Chloroquine; Codon; Drug Combinations; Drug Resistance; Humans; | 2007 |
Real-time PCR assay for rapid detection and analysis of PfCRT haplotypes of chloroquine-resistant Plasmodium falciparum isolates from India.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Animals; Chloroquine; Drug Resistance; Gene | 2007 |
[Study on the haplotypes of pfcrt polymorphism from Hainan Province].
Topics: Alleles; Animals; Antimalarials; Base Sequence; Chloroquine; Drug Resistance; Gene Frequency; Genoty | 2007 |
Low antiplasmodial activity of alkaloids and amides from the stem bark of Zanthoxylum rubescens (Rutaceae).
Topics: Alkaloids; Amides; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; In | 2007 |
The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics.
Topics: Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; Drug Combinations; Drug Therapy, Comb | 2007 |
Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys.
Topics: Animals; Antimalarials; Aotidae; Chloroquine; Cytochromes b; Dihydropteroate Synthase; Disease Model | 2007 |
[Polymorphisms of the pfmdr1 gene in field samples of Plasmodium falciparum and their association with therapeutic response to antimalarial drugs and severe malaria in Colombia].
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Colombia; Drug Resistance, Multiple; Humans; Malar | 2007 |
A longitudinal investigation of Plasmodium falciparum malaria in children in northern India.
Topics: Animals; Antibodies, Protozoan; Antibody Specificity; Antigens, Protozoan; Antimalarials; Child, Pre | 2008 |
Marked differences in the prevalence of chloroquine resistance between urban and rural communities in Burkina Faso.
Topics: Animals; Burkina Faso; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria, Falc | 2008 |
A case of hyper-reactive malarial splenomegaly. The role of rapid antigen-detecting and PCR-based tests.
Topics: Aged; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Chloroquine; Humans; Malar | 2008 |
No genetic bottleneck in Plasmodium falciparum wild-type Pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance.
Topics: Alleles; Animals; Antimalarials; China; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; M | 2008 |
Prevalence of mutations associated with antimalarial drugs in Plasmodium falciparum isolates prior to the introduction of sulphadoxine-pyrimethamine as first-line treatment in Iran.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Dihydropteroate Syn | 2007 |
Assessment of in vitro antimalarial interactions between dihydroartemisinin and fosmidomycin.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Dose-Response Relationship, Drug; Drug Interactio | 2007 |
The treatment of falciparum malaria with intramuscular chloroquine.
Topics: Chloroquine; Humans; Injections, Intramuscular; Malaria, Falciparum | 1949 |
Carriers, channels and chloroquine efficacy in Guinea-Bissau.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Guinea-Bissau; Humans; Ion Channels; Malaria, | 2008 |
Drug-resistant malaria parasites introduced into Madagascar from Comoros Islands.
Topics: Adult; Animals; Antimalarials; Child, Preschool; Chloroquine; Comoros; Drug Resistance, Multiple; Fe | 2007 |
Baseline in vitro efficacy of ACT component drugs on Plasmodium falciparum clinical isolates from Mali.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Microbial; Enzyme-Linked Immunos | 2008 |
Transfer of chloroquine and desethylchloroquine across the placenta and into milk in Melanesian mothers.
Topics: Adult; Antimalarials; Area Under Curve; Breast Feeding; Chloroquine; Chromatography, High Pressure L | 2008 |
Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso.
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Burkina Faso; Child; Child, Preschool; Chlor | 2008 |
In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon.
Topics: Animals; Antimalarials; Brazil; Chloroquine; Drug Resistance; Erythrocytes; Ethanol; Malaria, Falcip | 2008 |
Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment.
Topics: Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Chlorpheniramine; Clinica | 2008 |
Anti-protozoan activities of Harungana madagascariensis stem bark extract on trichomonads and malaria.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Antitrichomonal Agents; Artemether; Artemisinins; Chlo | 2008 |
Association of pfcrt but not pfmdr1 alleles with chloroquine resistance in Iranian isolates of Plasmodium falciparum.
Topics: Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Gene Amplif | 2008 |
Clinical diagnosis of malaria and the risk of chloroquine self-medication in rural health centres in Burkina Faso.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Burkina Faso; Child; Child, Preschool; Ch | 2008 |
Chloroquine prophylaxis associated with high prevalence of Plasmodium falciparum pfcrt K76T mutation in people with sickle-cell disease in Benin City, Nigeria.
Topics: Anemia, Sickle Cell; Animals; Antimalarials; Chemoprevention; Chloroquine; Drug Resistance; Humans; | 2008 |
In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Microbial; Global Health; Humans | 2008 |
Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Asia; ATP-Binding Cassette Transporters; Chloroquine; Drug Resistanc | 2008 |
Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Colombia; Drug Resistance; Humans; Malaria, Falcip | 2008 |
Revising antimalarial drug policy in Central America: experience in Panama.
Topics: Adult; Animals; Antimalarials; Child, Preschool; Chloroquine; DNA, Protozoan; Drug Resistance; Fatal | 2008 |
Assessment of the therapeutic efficacy of chloroquine in the treatment of uncomplicated Plasmodium falciparum malaria in a tribal block of the Kalahandi district of Orissa, India.
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Humans; India; Malaria, Fal | 2008 |
Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Workers; | 2008 |
Malaria--an experience at CMH Khuzdar (Balochistan).
Topics: Antimalarials; Chloroquine; Disease Outbreaks; Doxycycline; Female; Humans; Malaria, Falciparum; Mal | 2008 |
The potential use of methotrexate in the treatment of falciparum malaria: in vitro assays against sensitive and multidrug-resistant falciparum strains.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Humans; Hypoxanthine; Malaria, Falci | 2008 |
Tumour necrosis factor alpha in uncomplicated malaria in young adults.
Topics: Adolescent; Adult; Antimalarials; Case-Control Studies; Chloroquine; Drug Combinations; Enzyme-Linke | 1995 |
Falciparum malaria, imported into The Netherlands, 1979-1988. II. Clinical features.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Incidence; Malaria, | 1995 |
In vitro susceptibility of Plasmodium falciparum to chloroquine, amodiaquine, quinine, mefloquine, and sulfadoxine/pyrimethamine in Equatorial Guinea.
Topics: Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Equatorial Guinea; Human | 1995 |
The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity.
Topics: Adolescent; Adult; Age Factors; Antibodies, Protozoan; Child; Child, Preschool; Chloroquine; Female; | 1995 |
Chloroquine-resistant falciparum malaria in Mauritania.
Topics: Adult; Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Mauritania; Plasmo | 1995 |
Congenital malaria in a hyperendemic area: a preliminary study.
Topics: Chloroquine; Cross-Sectional Studies; Developing Countries; Drug Administration Schedule; Female; Hu | 1993 |
Changes in the resistance of Plasmodium falciparum to chloroquine in Hainan, China.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; China; Chloroquine; Drug Resista | 1995 |
Efficacy of a 3-day oral regimen of quinine in an area of northern Nigeria with low-grade resistance of Plasmodium falciparum to chloroquine and sulphadoxine-pyrimethamine.
Topics: Administration, Oral; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Administrat | 1995 |
Malaria prophylaxis. Mefloquine toxicity should limit its use to treatment alone.
Topics: Africa; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Falciparum; Mefloquine; Proguanil; Tra | 1995 |
Genetic changes in the population of Plasmodium falciparum in a Sudanese village over a three-year period.
Topics: Alleles; Aminohydrolases; Animals; Antigens, Protozoan; Antigens, Surface; Chloroquine; Electrophore | 1995 |
High proportion of subclinical Plasmodium falciparum infections in an area of seasonal and unstable malaria in Sudan.
Topics: Adolescent; Adult; Amino Acid Sequence; Animals; Antibodies, Protozoan; Antigens, Protozoan; Child; | 1995 |
Plasmodium falciparum: detection of P-glycoprotein in chloroquine-susceptible and chloroquine-resistant clones and isolates.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Chloroquine; | 1995 |
Quinine resistant falciparum malaria acquired in east Africa.
Topics: Adult; Africa, Eastern; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falci | 1995 |
Sensitivity to antimalarial drugs by Plasmodium falciparum in Goundry, Oubritenga province, Burkina Faso.
Topics: Amodiaquine; Animals; Antimalarials; Burkina Faso; Child; Child, Preschool; Chloroquine; Drug Resist | 1994 |
[Antimalarial active 10 H-indolo(3,2-b)quinolin-11-yl-amine. 2. Chloroquine analogs].
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Humans; In Vitro Techniques; Indoles; Magnetic | 1995 |
Drug-resistant Plasmodium falciparum malaria in the eastern Transvaal.
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum | 1994 |
In vivo sensitivity of Plasmodium falciparum to chloroquine in rural areas of Côte d'Ivoire.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Cote d'Ivoire; Drug Resistance; Follow-Up | 1994 |
High level chloroquine resistance of Plasmodium falciparum in Madras, Tamil Nadu.
Topics: Adult; Animals; Chloroquine; Doxycycline; Drug Resistance; Humans; India; Malaria, Falciparum; Male; | 1994 |
Halofantrine in acute malaria.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Malaria, Vivax; Phenanthre | 1994 |
Antimalarials during pregnancy: a cost-effectiveness analysis.
Topics: Antimalarials; Chloroquine; Cost-Benefit Analysis; Decision Support Techniques; Drug Combinations; F | 1995 |
Congenitally acquired chloroquine-resistant P. falciparum malaria in an infant born in the United States.
Topics: Adult; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans; Infant; Malaria, Falciparum; | 1995 |
Atypical presentations of malaria associated with chloroquine resistance.
Topics: Animals; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria, Falcipa | 1995 |
Effect of Plasmodium falciparum malaria on plasma fibrinopeptide-A (FpA) concentration.
Topics: Acute Disease; Adolescent; Adult; Blood Coagulation Tests; Case-Control Studies; Child; Child, Presc | 1995 |
An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire.
Topics: Adolescent; Adult; Blackwater Fever; Child; Chloroquine; Female; Glucosephosphate Dehydrogenase Defi | 1995 |
Persistent fever in severe malaria in children.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Chloroquine; Chronic Disease; Drug Resistance; Femal | 1994 |
Hyper parasitaemia due to plasmodium falciparum malaria.
Topics: Animals; Chloroquine; Host-Parasite Interactions; Humans; Infusions, Intravenous; Injections, Intram | 1994 |
[Malaria in children at the Sihanoukville Hospital (Cambodia)].
Topics: Cambodia; Child; Chloroquine; Hospitals; Humans; Malaria; Malaria, Cerebral; Malaria, Falciparum; Ma | 1994 |
Chloroquine resistance in malaria.
Topics: Child; Chloroquine; Drug Resistance; Humans; Incidence; India; Malaria, Falciparum; Malaria, Vivax | 1994 |
Plasmodium falciparum and Plasmodium vivax: lactate dehydrogenase activity and its application for in vitro drug susceptibility assay.
Topics: Animals; Antimalarials; Chloroquine; Colorimetry; Erythrocytes; Humans; L-Lactate Dehydrogenase; Mal | 1995 |
Death from malaria.
Topics: Adult; Chloroquine; Drug Resistance; Female; Humans; Infant, Newborn; Kenya; Malaria, Falciparum; Pr | 1994 |
Response of chloroquine-resistant falciparum malaria to sulfadoxine/pyrimethamine in Gokwe area of Zimbabwe.
Topics: Adult; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Monitoring; Drug Resistance; Follo | 1994 |
Serum complement levels in asymptomatic Plasmodium falciparum parasitaemic children.
Topics: Child; Child, Preschool; Chloroquine; Complement System Proteins; Humans; Infant; Malaria, Falciparu | 1994 |
Falciparum malaria in naturally infected human patients: VIII. Fine structure of intraerythrocytic asexual forms before and during chloroquine treatment.
Topics: Adult; Animals; Chloroquine; Endocytosis; Erythrocytes; Female; Humans; Malaria, Falciparum; Microsc | 1994 |
Response of P. falciparum to chloroquine in Car Nicobar Island.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Plasmodium falciparum | 1994 |
In-vitro chloroquine resistance of P. falciparum in Vellore, Tamil Nadu.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Plasmodium falcip | 1994 |
Some observations on malaria in Boko PHC of Kamrup District, Assam.
Topics: Adolescent; Adult; Animals; Anopheles; Child; Child, Preschool; Chloroquine; Disease Vectors; Drug R | 1994 |
Plasmodium falciparum sensitivity in "in-vivo" and its distribution in geo-ecological zones of Gujarat.
Topics: Adolescent; Age Factors; Animals; Child; Child, Preschool; Chloroquine; Climate; Drug Resistance; Ec | 1994 |
Comparative efficacy of chloroquine and amodiaquine in Plasmodium falciparum strain of north-eastern India.
Topics: Amodiaquine; Animals; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Plasmodium f | 1994 |
In vivo response of falciparum malaria to chloroquine in southern Thailand.
Topics: Adolescent; Adult; Aged; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mi | 1994 |
Ten-year surveillance of drug-resistant malaria in Burkina Faso (1982-1991).
Topics: Adolescent; Animals; Antimalarials; Burkina Faso; Child; Chloroquine; Drug Resistance; Humans; Longi | 1994 |
Falciparum malaria treated with a chloroquine suspension administered rectally in Trinidad.
Topics: Administration, Rectal; Adult; Chloroquine; Developing Countries; Humans; Malaria, Falciparum; Male; | 1994 |
[Avoid routine malaria prophylaxis for Southeastern Asia. The risk of infection is low for the customary traveller].
Topics: Asia, Southeastern; Chloroquine; Humans; Malaria, Falciparum; Risk Factors; Scandinavian and Nordic | 1994 |
[Cytokines and malaria. A study of TNF-alpha, IL1-beta, IL6 and IL2R in 28 patients].
Topics: Adolescent; Adult; Amodiaquine; C-Reactive Protein; Chloroquine; Humans; Interleukin-1; Interleukin- | 1994 |
Susceptibility of Plasmodium falciparum to chloroquine and mefloquine in Ouagadougou area (Burkina Faso).
Topics: Animals; Burkina Faso; Child; Child, Preschool; Chloroquine; Drug Evaluation; Drug Resistance; Femal | 1993 |
Chloroquine resistant Plasmodium falciparum in coastal Tanzania. A challenge to the continued strategy of village based chemotherapy for malaria control.
Topics: Animals; Child; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum; Sa | 1994 |
Treatment of malaria fever episodes among children in Malawi: results of a KAP survey.
Topics: Algorithms; Ambulatory Care Facilities; Antimalarials; Caregivers; Child; Child, Preschool; Chloroqu | 1994 |
What's new in malaria.
Topics: Adult; Africa; B-Lymphocytes; Child, Preschool; Chloroquine; Female; Humans; Humidity; Infant; Malar | 1994 |
[Subacute Plasmodium falciparum malaria in 43 patients returning from areas with chloroquine in Africa].
Topics: Adult; Africa; Aged; Antibodies, Protozoan; Blood Cell Count; Chloroquine; Drug Resistance; Female; | 1994 |
Vivax malaria resistant to treatment and prophylaxis with chloroquine.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; DNA, Protozoan; Drug Resistance, Microbial; | 1993 |
Chloroquine for treatment of falciparum malaria in Madagascar.
Topics: Animals; Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum | 1993 |
Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa.
Topics: Adult; Antimalarials; Chloroquine; Female; Humans; Kenya; Malaria, Falciparum; Male; Mefloquine; Mid | 1993 |
Mefloquine prophylaxis.
Topics: Chloroquine; Humans; Malaria, Falciparum; Mefloquine | 1993 |
Chloroquine-resistant falciparum malaria in an area of rising endemicity in Zimbabwe.
Topics: Absenteeism; Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Diseas | 1994 |
In vitro activity of bisquinoline WR268,668 against African clones and isolates of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Chloroquine; Cyclohexylamines; Desipramine; Drug Interactions; Drug | 1994 |
[Difficulties of diagnosis and treatment of malaria outbreaks in Europeans living in Burkina Faso].
Topics: Adult; Burkina Faso; Child, Preschool; Chloroquine; Drug Resistance; Europe; Humans; Infant; Malaria | 1993 |
In vitro and in vivo chloroquine-potentiating action of Strychnos myrtoides alkaloids against chloroquine-resistant strains of Plasmodium malaria.
Topics: Alkaloids; Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance; Drug Synergism; HeLa Cel | 1994 |
Experimental infections of Anopheles gambiae with Plasmodium falciparum of naturally infected gametocyte carriers in Cameroon: factors influencing the infectivity to mosquitoes.
Topics: ABO Blood-Group System; Adolescent; Adult; Age Factors; Amodiaquine; Animals; Anopheles; Aspirin; Bo | 1993 |
[A case of mefloquine-resistant Plasmodium falciparum malaria with convulsion after antimalarial treatment].
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Male; Mefloquine; Seizure | 1994 |
Falciparum malaria in naturally infected human patients: IV--Ultrastructural changes in peripheral white blood cells.
Topics: Acute Disease; Adolescent; Adult; Child; Child, Preschool; Chloroquine; Humans; Leukocytes; Lymphocy | 1993 |
Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum.
Topics: Animals; Biological Transport, Active; Chloroquine; Desipramine; Drug Resistance; Humans; Hydrogen-I | 1994 |
[Aspects of Plasmodium falciparum sensitivity to chloroquine in Madagascar from 1982 to 1993].
Topics: Animals; Chloroquine; Drug Resistance; Fever; Humans; Madagascar; Malaria, Falciparum; Plasmodium fa | 1993 |
Sulphadoxine-pyrimethamine and chloroquine resistant Plasmodium falciparum infection in Sri Lanka.
Topics: Adult; Animals; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Male; | 1994 |
In vitro responses of P. falciparum parasites to chloroquine, amodiaquine and quinine in two ecological zones in Ghana.
Topics: Amodiaquine; Animals; Child; Chloroquine; Drug Resistance; Ghana; Humans; Malaria, Falciparum; Plasm | 1993 |
Malaria chemoprophylactic regimens for travellers.
Topics: Chloroquine; Doxycycline; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mefloquine; Progua | 1994 |
Efficacy of chloroquine on Plasmodium falciparum transmitted at Amani, eastern Usambara Mountains, north-east Tanzania: an area where malaria has recently become endemic.
Topics: Adolescent; Adult; Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Dose-Response Relatio | 1993 |
[Evolution of Plasmodium falciparum drug sensitivity in Madagascar from 1982 to 1993 and operational consequences].
Topics: Bias; Biological Availability; Chloroquine; Drug Resistance; Humans; Madagascar; Malaria, Falciparum | 1993 |
In-vivo and in-vitro sensitivity of Plasmodium falciparum to chloroquine at Indian Oil Corporation, Mathura (U.P.).
Topics: Animals; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Humans; India; Malaria, Fal | 1993 |
[Malaria in the Saharan region of Senegal. 2. Parasitological indices].
Topics: Animals; Child; Child, Preschool; Chloroquine; Humans; Infant; Infant, Newborn; Longitudinal Studies | 1993 |
Enhancement of drug susceptibility in Plasmodium falciparum in vitro and Plasmodium berghei in vivo by mixed-function oxidase inhibitors.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Cimetidine; Cytochrome P-450 Enzyme Inhib | 1993 |
[Acute respiratory failure in tropical malaria during pregnancy. Successful treatment using extracorporeal CO2 elimination].
Topics: Acute Disease; Adult; Carbon Dioxide; Cesarean Section; Chloroquine; Drug Therapy, Combination; Extr | 1993 |
Assessment of the response in vivo and in vitro of Plasmodium falciparum to sulphadoxine-pyrimethamine in the malarious areas of Iran.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amodiaquine; Animals; Child; Child, Preschool; Chloroqui | 1993 |
Upsurge of malaria-related convulsions in a paediatric emergency room in Nigeria. Consequence of emergence of chloroquine-resistant Plasmodium falciparum.
Topics: Age Factors; Child; Child, Preschool; Chloroquine; Drug Resistance; Emergency Service, Hospital; Hos | 1993 |
Evolution of chloroquine resistance in central and west Africa.
Topics: Africa, Central; Africa, Western; Animals; Chloroquine; Drug Resistance; France; Humans; In Vitro Te | 1993 |
Curative efficacy of norfloxacin in falciparum malaria.
Topics: Adolescent; Adult; Chloroquine; Drug Administration Schedule; Female; Humans; Malaria, Falciparum; M | 1993 |
Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys.
Topics: Animals; Aotus trivirgatus; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Cyproheptadine; D | 1993 |
Malaria during pregnancy: neonatal morbidity and mortality and the efficacy of chloroquine chemoprophylaxis.
Topics: Birth Weight; Chloroquine; Drug Resistance; Female; Fetal Death; Humans; Infant, Newborn; Malaria, F | 1993 |
Prospective in-vivo study of chloroquine resistance of Plasmodium falciparum in Zambian under-fives.
Topics: Animals; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Infant, Newborn; Malaria, F | 1993 |
Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo.
Topics: Animals; Antimalarials; Aotus trivirgatus; Artemether; Artemisinins; Chloroquine; Disease Models, An | 1993 |
[Imported malaria: 6 cases, 2 of them with an erythrocyte glucose-6-phosphate dehydrogenase deficiency].
Topics: Adolescent; Adult; Aged; Chloroquine; England; Erythrocytes; Female; France; Glucosephosphate Dehydr | 1993 |
[In vivo resistance of Plasmodium falciparum to chloroquine in Anjouan (Comoros)].
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Comoros; Drug Resistance; Female; | 1993 |
A national survey of the prevalence of chloroquine resistant Plasmodium falciparum in Burkina Faso.
Topics: Animals; Burkina Faso; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria, Falci | 1993 |
Sensitivity of Plasmodium falciparum to chloroquine in pregnant women in Zaria, northern Nigeria.
Topics: Animals; Chloroquine; Drug Resistance; Female; Hospitals, General; Humans; In Vitro Techniques; Mala | 1993 |
Efficacy of intramuscular amopyroquin for treatment of Plasmodium falciparum malaria in the Gabon Republic.
Topics: Adolescent; Aminoquinolines; Animals; Antimalarials; Body Temperature; Child; Child, Preschool; Chlo | 1993 |
The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites.
Topics: Adult; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Bridged Bicyclo Compounds, Heteroc | 1995 |
A case of dual chloroquine and halofantrine treatment failure in Zimbabwe.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; | 1995 |
[In vivo evaluation of Plasmodium falciparum sensitivity to chloroquine in Moundou, Chad].
Topics: Animals; Antimalarials; Chad; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malari | 1995 |
Canadian recommendations for the prevention and treatment of malaria among international travellers. Committee to Advise on Tropical Medicine and Travel (CATMAT).
Topics: Animals; Antimalarials; Canada; Child; Chloroquine; Culicidae; Drug Resistance; Female; Humans; Mala | 1995 |
Malaria among United States troops in Somalia.
Topics: Anti-Bacterial Agents; Antimalarials; Chemoprevention; Chloroquine; Clothing; Cohort Studies; Doxycy | 1996 |
Falciparum malaria, imported into The Netherlands, 1979-1988. I. Epidemiological aspects.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Humans; Mala | 1995 |
Susceptibility of Plasmodium falciparum to chloroquine in tea garden tribes of Assam, India.
Topics: Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Hum | 1995 |
[Sensitivity in vivo and in vitro of Plasmodium falciparum to chloroquine and amodiaquine in Bangangte (west Cameroon)].
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chloroqui | 1995 |
[Epidemiological surveillance of Plasmodium falciparum sensitivity to chloroquine in Cameroon: necessity of public health policy adaptation].
Topics: Antimalarials; Cameroon; Chloroquine; Drug Resistance; Drug Utilization; Health Policy; Humans; Long | 1995 |
Increasing chloroquine resistance -- the Mpumalanga Lowveld story, 1990-1995.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Mass Screening; P | 1996 |
Field research, relief work and war: does chloroquine-resistance occur in displaced populations of southern Sudan?
Topics: Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria, Falciparum; | 1996 |
The effect of malaria and malaria prevention in pregnancy on offspring birthweight, prematurity, and intrauterine growth retardation in rural Malawi.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Female; Fetal Growth Retardation; Humans; Infant, Low | 1996 |
Impairment of a pregnant woman's acquired ability to limit Plasmodium falciparum by infection with human immunodeficiency virus type-1.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Delivery, Obstetric; Female; Fetal Blood; HIV Infecti | 1996 |
Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Female; Fetal Death; Fever; Humans; Malaria, Falcipar | 1996 |
Evaluation of maternal practices, efficacy, and cost-effectiveness of alternative antimalarial regimens for use in pregnancy: chloroquine and sulfadoxine-pyrimethamine.
Topics: Antimalarials; Chloroquine; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Health Knowled | 1996 |
Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa.
Topics: Africa South of the Sahara; Alleles; Animals; Antimalarials; Base Sequence; Chloroquine; Codon; DNA | 1995 |
[Diagnostic and prognostic importance of laboratory tests in malaria in airports. Study of six recent cases].
Topics: Adult; Aerospace Medicine; Antimalarials; Chloroquine; Female; France; Humans; Malaria, Falciparum; | 1996 |
Severe and complicated malaria in KwaZulu-Natal.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Animals; Antimalarials; Child; Chl | 1996 |
Resurgence of malaria and drug resistance in Plasmodium falciparum and vivax species in Bombay.
Topics: Antimalarials; Chloroquine; Drug Resistance; Follow-Up Studies; Humans; India; Malaria, Falciparum; | 1996 |
Resistance to chloroquine therapy in pregnant women with malaria parasitemia.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Kenya; Malaria, Falcipa | 1996 |
A quantification methodology of conversion rate based on field detected RI cases to RII-RIII cases--an approach for an alternative anti-malaria drug strategy.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Forecasting; Health Planning; | 1996 |
In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs.
Topics: Adult; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Drug Evaluation, P | 1996 |
In vitro susceptibilities of field isolates of Plasmodium falciparum to chloroquine in Mpumalanga.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria, Falciparum; Microb | 1996 |
Using community health workers for malaria control: experience in Zaire.
Topics: Adolescent; Algorithms; Antimalarials; Child; Child, Preschool; Chloroquine; Community Health Worker | 1996 |
In vitro drug sensitivity and clinical aspects of Plasmodium falciparum malaria in African children.
Topics: Animals; Child; Child, Preschool; Chloroquine; Congo; Humans; Infant; Malaria, Falciparum; Mefloquin | 1995 |
Short report: gametocytes, chloroquine pressure, and the relative parasite survival advantage of resistant strains of falciparum malaria in west Africa.
Topics: Adolescent; Adult; Age Factors; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; | 1996 |
Epidemiological observations on malaria in villages of Buhari PHC, Surat, Gujarat.
Topics: Adolescent; Adult; Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Res | 1995 |
Drug resistant Plasmodium falciparum in Mandla District, Madhya Pradesh.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; Drug Resistance, Microbial; Female; F | 1995 |
Risk factors of chloroquine resistance in Plasmodium falciparum malaria.
Topics: Age Factors; Animals; Antimalarials; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; | 1996 |
[In vitro sensitivity of 85 Plasmodium falciparum isolates in the Fatick region, Senegal].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Microbial Sensiti | 1996 |
Changes in protein turnover and resting energy expenditure after treatment of malaria in Gambian children.
Topics: Acetaminophen; Adolescent; Body Mass Index; Body Temperature; Body Weight; Child; Chloroquine; Energ | 1996 |
[Mechanisms and epidemiology of resistances to antimalarials].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Humans; Malaria, Fa | 1996 |
Response of Plasmodium falciparum to chloroquine in Digboi area of Assam, India.
Topics: Adolescent; Adult; Age Distribution; Antimalarials; Child; Child, Preschool; Chloroquine; Disease Ou | 1996 |
Chloroquine resistance of Plasmodium falciparum malaria in Ethiopia and Eritrea.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Child; Child, Preschool; Chloroquine; Dru | 1996 |
Severe falciparum malaria with hyperparasitaemia: management without exchange blood transfusion.
Topics: Adolescent; Animals; Antimalarials; Chloroquine; Female; Fetal Death; Humans; Malaria, Falciparum; P | 1996 |
A study of sensitivity of P. falciparum to chloroquine in a rural area of Bharuch district, Gujarat. SEWA-Rural Research Team. Society for Education, Welfare and Action.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance, Mi | 1996 |
High prevalence of chloroquine resistant Plasmodium falciparum infection in Rajasthan epidemic.
Topics: Animals; Antibodies, Protozoan; Antimalarials; Chloroquine; Disease Outbreaks; Drug Resistance, Micr | 1996 |
Survey of in vivo sensitivity to chloroquine by Plasmodium falciparum and P. vivax in Lombok, Indonesia.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Hu | 1997 |
Resurgence of malaria and drug resistance in plasmodium falciparum and plasmodium vivax species in Bombay.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Section | 1995 |
Reversible suppression of bone marrow response to erythropoietin in Plasmodium falciparum malaria.
Topics: Antimalarials; Bone Marrow; Bone Marrow Diseases; Child; Child, Preschool; Chloroquine; Erythropoies | 1997 |
Plasma cholesterol, B-carotene and ascorbic acid changes in human malaria.
Topics: Adolescent; Adult; Antimalarials; Ascorbic Acid; beta Carotene; Chloroquine; Cholesterol; Convalesce | 1995 |
Chloroquine-resistant Plasmodium falciparum malaria: report of two locally acquired infections in Saudi Arabia.
Topics: Adolescent; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Male; Middle A | 1997 |
Malaria in Mvumi, central Tanzania and the in vivo response of Plasmodium falciparum to chloroquine and sulphadoxine pyrimethamine.
Topics: Adolescent; Adult; Aged; Animals; Anopheles; Antimalarials; Child; Chloroquine; Cross-Sectional Stud | 1997 |
Interaction of thyroxine sodium with antimalarial drugs.
Topics: Antimalarials; Chloroquine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypothyroi | 1997 |
Non-iron porphyrins inhibit beta-haematin (malaria pigment) polymerisation.
Topics: Antimalarials; Chloroquine; Dimerization; Hematoporphyrins; Hemeproteins; Hemin; Humans; Malaria, Fa | 1997 |
In vivo sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine in school children in Hoima district, western Uganda.
Topics: Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; | 1997 |
Post treatment sensitivity studies with the ParaSight-F test for malaria diagnosis in Zimbabwe.
Topics: Antimalarials; Chloroquine; False Negative Reactions; False Positive Reactions; Humans; Malaria, Fal | 1997 |
Plasmodium falciparum chloroquine and quinine sensitivity in asymptomatic and symptomatic children in São Tomé Island.
Topics: Adolescent; Animals; Antimalarials; Atlantic Islands; Child; Child, Preschool; Chloroquine; Drug Res | 1997 |
False chloroquine resistance in Africa.
Topics: Africa; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Dose-Response Relationship | 1997 |
Chloroquine resistant falciparum malaria--the Indian scene.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Plasmodium | 1996 |
Efficacy of sulfadoxine-pyrimethamine in chloroquine resistant falciparum malaria in Bombay.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans; Indi | 1996 |
Status of Plasmodium falciparum resistance to chloroquine in Orissa.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Population Surveill | 1997 |
Coexistence of enteric fever with malaria.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antimalarials; Brain Diseases; Chloroquine; Ciprofloxa | 1995 |
Modified antimalarial treatment for chloroquin resistant plasmodium falciparum infection.
Topics: Antimalarials; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Malaria, Falciparum; Pyrimeth | 1995 |
Chloroquine resistant falciparum malaria in the Andamans.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Ind | 1995 |
[In vivo chemosensitivity tests of Plasmodium falciparum to chloroquine in Senegal: the development of resistance and the assessment of therapeutic efficacy].
Topics: Administration, Oral; Adolescent; Adult; Aged; Ambulatory Care; Animals; Antimalarials; Bias; Chemop | 1997 |
[Will a gametocytocide combined with an antimalarial schizonticide soon be necessary in areas of drug resistance?].
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Gametogenesis; Humans; Mala | 1997 |
In-vivo and in-vitro sensitivity of Plasmodium falciparum to chloroquine in Chennai (Tamil Nadu), India.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Female; Humans; Malaria, Falciparum; Male; M | 1997 |
World malaria situation in 1994. Part I. Population at risk.
Topics: Adolescent; Adult; Africa; Age Distribution; Antimalarials; Asia; Child; Child, Preschool; Chloroqui | 1997 |
Anti-malarial drug resistance, malnutrition and socio-economic status.
Topics: Adolescent; Antimalarials; Case-Control Studies; Child; Child, Preschool; Chloroquine; Drug Resistan | 1997 |
Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria.
Topics: Anemia; Blood Circulation; CD3 Complex; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8-Positi | 1997 |
Early diagnosis and treatment of malaria in a refugee population in Sri Lanka.
Topics: Adult; Antimalarials; Blood; Child; Chloroquine; Cost-Benefit Analysis; Developing Countries; Health | 1997 |
In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides.
Topics: Alkaloids; Antimalarials; Benzylisoquinolines; Chloroquine; Erythrocytes; Fibroblasts; Humans; Isoqu | 1997 |
Plasmodium falciparum malaria.
Topics: Adult; Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; P | 1997 |
Effect of previous chloroquine intake on in vivo P. falciparum drug sensitivity.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Drug Resistance; Emigration and Immigration; H | 1997 |
A bioassay for evaluating antimalarial activity and for measuring concentration in plasma.
Topics: Adolescent; Adult; Biological Assay; Child; Chloroquine; Chromatography, High Pressure Liquid; Human | 1997 |
Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria.
Topics: Adolescent; Adult; Antimalarials; Artemether; Artemisinins; Child; Child, Preschool; Chloroquine; Dr | 1997 |
Resistance of falciparum malaria to chloroquine and sulfadoxine-pyrimethamine in Afghan refugee settlements in western Pakistan: surveys by the general health services using a simplified in vivo test.
Topics: Adolescent; Adult; Afghanistan; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinatio | 1997 |
Decreased erythropoietin response in Plasmodium falciparum malaria-associated anaemia.
Topics: Adolescent; Adult; Anemia; Cell Line; Chloroquine; Erythropoietin; Ferritins; Humans; Interleukin-6; | 1997 |
Chloroquine resistance in Pakistan and the upsurge of falciparum malaria in Pakistani and Afghan refugee populations.
Topics: Afghanistan; Antimalarials; Chloroquine; Drug Resistance; Humans; Incidence; Insect Control; Malaria | 1997 |
In-vivo resistance of Plasmodium falciparum to chloroquine and amodiaquine in south Cameroon and age-related efficacy of the drugs.
Topics: Adolescent; Age Factors; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chl | 1997 |
Chloroquine resistance--discovering the missing link?
Topics: Animals; Antimalarials; Chloroquine; Crosses, Genetic; DNA, Protozoan; Drug Resistance; Genes, Proto | 1998 |
A simplified in vivo drug sensitivity test for malaria in the field.
Topics: Adult; Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance; Female; Human | 1997 |
Malaria: an unresolved problem.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; History, 19th Century; History, 20t | 1997 |
[Impact of antimalarial drug accessibility on malarial morbidity and chloroquine resistance. A study carried out in Touba (Senegal)].
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Drug Util | 1997 |
On achieving consensus on the prevention of malaria.
Topics: Antimalarials; Chemoprevention; Chloroquine; Guidelines as Topic; Humans; Malaria, Falciparum; Meflo | 1998 |
Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum.
Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Dose-Response Relationship, Drug; Dru | 1998 |
Resistance of Plasmodium falciparum malaria to amodiaquine, chloroquine and quinine in the Madang Province of Papua New Guinea, 1990-1993.
Topics: Acute Disease; Amodiaquine; Animals; Antimalarials; Case-Control Studies; Child; Child, Preschool; C | 1996 |
In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; E | 1998 |
Acute generalized exanthematous pustulosis due to the combination of chloroquine and proguanil.
Topics: Acute Disease; Adult; Animals; Antimalarials; Chloroquine; Drug Eruptions; Drug Therapy, Combination | 1998 |
A primary malarial infection is composed of a very wide range of genetically diverse but related parasites.
Topics: Africa; Animals; Antimalarials; Biomarkers; Chloroquine; Clone Cells; Culicidae; Drug Resistance; Ge | 1998 |
Enhancement of the antimalarial effect of chloroquine by chloropheniramine in vivo.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Synergism; Female; Histamine H1 Antagonist | 1998 |
Antifolate-resistant malaria infections in Mpumalanga.
Topics: Antimalarials; Chloroquine; Drug Resistance, Multiple; Folic Acid Antagonists; Humans; Malaria, Falc | 1998 |
Follow-up of the susceptibility of Plasmodium falciparum to antimalarials in Gabon.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance | 1998 |
In vitro and in vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine.
Topics: Adult; Animals; Antimalarials; Antipruritics; Aotidae; Aotus trivirgatus; Chloroquine; Disease Model | 1998 |
[Surveillance of the in vivo sensitivity of Plasmodium falciparum to antimalarial agents: the results of initial tests of the OCEAC Malaria Network].
Topics: Africa, Central; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chloroquine | 1997 |
Modelling the chloroquine chemotherapy of falciparum malaria: the value of spacing a split dose.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Administration Schedule; | 1998 |
The effect of chemoprophylaxis on the timing of onset of falciparum malaria.
Topics: Antimalarials; Chemoprevention; Chloroquine; Drug Combinations; Female; Humans; Malaria, Falciparum; | 1998 |
Effectiveness of chemoprophylaxis and other determinants of malaria in travellers to Kenya.
Topics: Adult; Animals; Antimalarials; Case-Control Studies; Chloroquine; Humans; Kenya; Malaria, Falciparum | 1998 |
In vitro sensitivity of Plasmodium falciparum to halofantrine compared with chloroquine, quinine and mefloquine in the region of Bobo-Dioulasso, Burkina Faso (West Africa).
Topics: Animals; Antimalarials; Burkina Faso; Chloroquine; Drug Resistance; Malaria, Falciparum; Mefloquine; | 1998 |
[Dynamics of Plasmodium falciparum gametocytemia as a function of therapeutic response to chloroquine in a mesoendemic malaria zone].
Topics: Adolescent; Adult; Animals; Blood; Child; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; | 1998 |
[No variation in chloroquine resistance (Plasmodium falciparum) from 1986 to 1996 in semi-immune children in Brazzaville (Congo)].
Topics: Child; Chloroquine; Congo; Drug Resistance; Humans; Immunity, Innate; Malaria, Falciparum | 1998 |
A systematic approach to the development of a rational malaria treatment policy in Zambia.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Evaluation; Drug Resist | 1998 |
Studies on malaria during pregnancy in a tribal area of central India (Madhya Pradesh).
Topics: Adult; Antimalarials; Chloroquine; Female; Fever; Hemoglobins; Humans; India; Malaria; Malaria, Falc | 1998 |
Impact of chloroquine resistance on malaria mortality.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Infant, Newbor | 1998 |
Chloroquine resistant malaria in children.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; I | 1998 |
[Considering disparities in resistance of Plasmodium falciparum in Africa in chemoprevention decisions].
Topics: Africa; Animals; Antimalarials; Chloroquine; Cross-Cultural Comparison; Dose-Response Relationship, | 1998 |
[Malaria in an urban environment: the case of the city of Rufisque in Senegal].
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Humans; Inciden | 1997 |
[Prevalence of malaria in Dakar, Senegal. Results of serological survey of pregnant and non-pregnant women].
Topics: Adolescent; Adult; Antibodies, Protozoan; Antimalarials; Chloroquine; Female; Humans; Malaria, Falci | 1997 |
[Malaria prophylaxis].
Topics: Antimalarials; Chloroquine; Global Health; Humans; Malaria, Falciparum | 1998 |
In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine.
Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Child; Child, Preschool; | 1998 |
Malaria situation in several villages around Timika, south central Irian Jaya, Indonesia.
Topics: Adolescent; Age Distribution; Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroquin | 1998 |
Status of chloroquine efficacy against falciparum malaria in the Mola area of Kariba district, Zimbabwe.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Female; Follow-Up Studies; Humans; Infant; Mala | 1998 |
In vitro susceptibility of African isolates of Plasmodium falciparum from Gabon to pyronaridine.
Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Gabon; Humans | 1999 |
Comparison of in vivo and in vitro tests of resistance in patients treated with chloroquine in Yaoundé, Cameroon.
Topics: Adolescent; Adult; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resi | 1999 |
[Resistance to chloroquine and cycloguanil of Plasmodium falciparum in patients arriving in France after travel in Africa without chemoprophylaxis].
Topics: Africa; Animals; Antimalarials; Chloroquine; Codon; Drug Resistance, Multiple; Folic Acid Antagonist | 1998 |
[The proper use of antimalarial drugs currently available].
Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Contraindications; Drug Combinations; Drug Res | 1998 |
Chloroquine influences renal function in rural Zimbabweans with acute transient fever.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Blood Pressure; Chloroquin | 1999 |
[Pulmonary manifestations associated with malaria].
Topics: Adult; Anti-Bacterial Agents; Antimalarials; Bronchitis; Child; Chloroquine; Female; Humans; Infant, | 1998 |
In vivo testing of the therapeutic efficacy of chloroquine on falciparum malaria infections in Chirundu, Mashonaland West, Zimbabwe.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; | 1998 |
Malaria prophylaxis for the 1990s and beyond.
Topics: Antimalarials; Atovaquone; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; | 1997 |
In vitro susceptibility of African Plasmodium falciparum isolates to dihydroartemisinin and the risk factors for resistance to qinghaosu.
Topics: Africa; Animals; Antimalarials; Artemisinins; Chloroquine; Cross Reactions; Drug Evaluation, Preclin | 1998 |
Chloroquine increases Plasmodium falciparum gametocytogenesis in vitro.
Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Drug Resistance; Erythrocytes; Fluorescent Ant | 1999 |
Possible establishment of chloroquine-resistant P. falciparum in Saudi Arabia.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falcip | 1999 |
In vivo responses to antimalarials by Plasmodium falciparum and Plasmodium vivax from isolated Gag Island off northwest Irian Jaya, Indonesia.
Topics: Adolescent; Adult; Age Distribution; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; D | 1999 |
Severe subconjunctival haemorrhage associated with malaria.
Topics: Adult; Chloroquine; Conjunctival Diseases; Eye Hemorrhage; Humans; Malaria, Falciparum; Male; Remiss | 1999 |
Antimalarial drug resistance and combination chemotherapy.
Topics: Animals; Antimalarials; Artemisinins; Atovaquone; Chloroquine; Drug Resistance; Drug Therapy, Combin | 1999 |
Low frequency of complications in imported falciparum malaria: a review of 222 cases in south-eastern Norway.
Topics: Adolescent; Adult; Africa South of the Sahara; Aged; Animals; Antimalarials; Child; Child, Preschool | 1999 |
[In vitro sensitivity of Plasmodium falciparum isolates from Gabon to chloroquine and cycloguanil].
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Gabon; Hu | 1999 |
Does the availability of blood slide microscopy for malaria at health centers improve the management of persons with fever in Zambia?
Topics: Ambulatory Care Facilities; Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations | 1999 |
Artemisinin and its derivatives are transported by a vacuolar-network of Plasmodium falciparum and their anti-malarial activities are additive with toxic sphingolipid analogues that block the network.
Topics: Animals; Antimalarials; Artemisinins; Biological Transport; Chloroquine; Drug Resistance; Drug Syner | 1999 |
Analysis of kappa and omega repeats of the cg2 gene and chloroquine susceptibility in isolates of Plasmodium falciparum from sub-Saharan Africa.
Topics: Adolescent; Adult; Africa South of the Sahara; Aged; Animals; Antimalarials; Base Sequence; Child; C | 1999 |
[A story of the absurd!].
Topics: Aged; Antimalarials; Chloroquine; Dengue; Diagnosis, Differential; Female; Humans; Malaria, Falcipar | 1999 |
Efficacy and tolerability of a low-dose mefloquine-sulfadoxine-pyrimethamine combination compared with chloroquine in the treatment of acute malaria infection in a population with multiple drug-resistant Plasmodium falciparum.
Topics: Adolescent; Adult; Animals; Antimalarials; Blood; Child; Child, Preschool; Chloroquine; Drug Combina | 1999 |
Chemotherapy of malaria and resistance to antimalarial drugs in Guayana area, Venezuela.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug | 1999 |
Changing scenario of malaria: a study at Calcutta.
Topics: Animals; Antimalarials; Chloroquine; Female; Humans; India; Malaria, Falciparum; Malaria, Vivax; Mal | 1998 |
Plasmodium falciparum: drug-resistant malaria complicating leukemias and lymphomas in children.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Drug Ther | 1999 |
Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand.
Topics: Animals; Antimalarials; Blotting, Western; Chloroquine; DNA Fingerprinting; DNA, Protozoan; Drug Res | 1999 |
[Heterogeneity of chloroquine resistant malaria in Senegal].
Topics: Adolescent; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Infant, Newborn; | 1999 |
[Health assessments of a military company stationed on the Maroni River in French Guiana].
Topics: Acclimatization; Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Condoms; Crotalid Venom | 1999 |
Parasitological response of Plasmodium falciparum infection to chloroquine treatment in malaria patients in Port Moresby.
Topics: Adult; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Treat | 1997 |
Assessment of drug resistance to the malaria parasite in residents of Kampala, Uganda.
Topics: Antimalarials; Chloroquine; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Quinine; Uganda; | 1999 |
[Prevention of malaria].
Topics: Anti-Bacterial Agents; Antimalarials; Chloroquine; Doxycycline; Female; Humans; Malaria; Malaria, Fa | 1999 |
Current clinical efficacy of chloroquine for the treatment of Plasmodium falciparum infections in urban Dar es Salaam, United Republic of Tanzania.
Topics: Age Factors; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Evaluation; Human | 1999 |
Chloroquine resistance in Plasmodium falciparum and polymorphism of the CG2 gene.
Topics: Animals; Antigens, Surface; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum | 1999 |
Suboptimal prophylaxis for P. falciparum.
Topics: Antimalarials; Chloroquine; Fatal Outcome; Humans; Kenya; Malaria, Falciparum; Male; Mefloquine; Mid | 1999 |
Association of cg2 and pfmdr1 genotype with chloroquine resistance in field samples of Plasmodium falciparum from Nigeria.
Topics: Animals; ATP-Binding Cassette Transporters; Child; Child, Preschool; Chloroquine; Drug Resistance; G | 1999 |
Pseudo-reticulocytosis as a result of malaria parasites.
Topics: Afghanistan; Animals; Autoanalysis; Chloroquine; DNA; DNA, Protozoan; Electronic Data Processing; Er | 1999 |
[Apropos of Plasmodium falciparum malaria].
Topics: Antimalarials; Chloroquine; Diagnosis, Differential; Drug Resistance, Multiple; Humans; Malaria, Fal | 1999 |
Anti-malarial drug use among preschool children in an area of seasonal malaria transmission in Kenya.
Topics: Adult; Animals; Antibodies, Monoclonal; Antimalarials; Child, Preschool; Chloroquine; Cluster Analys | 1999 |
Analysis of mefloquine resistance and amplification of pfmdr1 in multidrug-resistant Plasmodium falciparum isolates from Thailand.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Chromosome Mapping; DNA Primers; DNA, Protozoan; D | 1999 |
Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Gambia; Hematocrit; Humans; Mala | 1999 |
Atovaquone-proguanil for falciparum malaria in the Philippines.
Topics: Antimalarials; Atovaquone; Chloroquine; Drug Combinations; Humans; Malaria, Falciparum; Naphthoquino | 2000 |
Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; In Vitro | 1999 |
Congenital malaria: diagnosis and therapy.
Topics: Animals; Antimalarials; Chloroquine; District of Columbia; Female; Fever; Humans; Infant; Jaundice; | 2000 |
[Chloroquine sensitivity of Plasmodium falciparum at the Gamkalley Clinic and the Nigerian armed forces PMI (Niamey, Niger)].
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Hu | 1999 |
Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria.
Topics: Alkaloids; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Interactions; Drug Resi | 2000 |
Epidemiological and control issues related to malaria in pregnancy.
Topics: Africa; Antimalarials; Bedding and Linens; Chloroquine; Drug Resistance; Endemic Diseases; Female; H | 1999 |
Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro.
Topics: Amsacrine; Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Enzyme Inhibitors; Etopos | 2000 |
Population dynamics of Plasmodium falciparum in an unstable malaria area of eastern Sudan.
Topics: Alleles; Animals; Antigens, Protozoan; Antimalarials; Chloroquine; Cohort Studies; DNA Primers; DNA, | 2000 |
Correlation of in vivo-resistance to chloroquine and allelic polymorphisms in Plasmodium falciparum isolates from Uganda.
Topics: Alleles; Animals; Antimalarials; ATP-Binding Cassette Transporters; Child; Chloroquine; Drug Resista | 2000 |
Chloroquine enhances viral replication and murine disease.
Topics: Alphavirus Infections; Animals; Antimalarials; Cardiovirus Infections; Chloroquine; Cytokines; Encep | 2000 |
Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates.
Topics: Amodiaquine; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antimalarials; Artemether; Arte | 2000 |
Epidemiologic tools for malaria surveillance in an urban setting of low endemicity along the Colombian Pacific coast.
Topics: Animals; Antimalarials; Blood; Blotting, Southern; Chloroquine; Colombia; Cross-Sectional Studies; D | 2000 |
Re: Drug-resistant falciparum malaria with bowel symptoms.
Topics: Abdomen, Acute; Adult; Antimalarials; Chloroquine; Drug Resistance; Humans; Ileal Diseases; Ileum; I | 2000 |
Management of a case of chloroquine-resistant falciparum malaria in a pregnant woman with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; F | 1999 |
The in vivo sensitivity of Plasmodium falciparum to chloroquine in the Red River basin, Yunnan, China.
Topics: Adult; Animals; Antimalarials; China; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falcipa | 1998 |
Chloroquine concentration profile in the community of Mewat region, district Gurgaon (Haryana), India.
Topics: Adult; Antimalarials; Body Weight; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; H | 1999 |
Clinical case definition of malaria at a secondary level hospital in northern India.
Topics: Analysis of Variance; Antimalarials; Case-Control Studies; Child; Chloroquine; Female; Fever; Humans | 1999 |
Resurgence of malaria in Mumbai--is escalating chloroquine resistance a cause?
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Incidence; India; Malaria, Falciparum | 1999 |
Prevention and treatment of malaria in UK travellers.
Topics: Age Factors; Antimalarials; Chloroquine; Contraindications; Doxycycline; Drug Resistance; Female; Hu | 2000 |
[Epidemiological, clinical and therapeutic aspects of severe malaria in adults in the infectious disease department of Central University Hospital of Dakar].
Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Female; Humans; Malaria, Falciparum; Male; Midd | 1999 |
Economic impact of febrile morbidity and use of permethrin-impregnated bed-nets in a malarious area I. Study of demographics, morbidity, and household expenditures associated with febrile morbidity in the Republic of Benin.
Topics: Adult; Animals; Anopheles; Antimalarials; Attitude to Health; Bedding and Linens; Benin; Child, Pres | 2000 |
Economic impact of febrile morbidity and use of permethrin-impregnated bed nets in a malarious area II. Determinants of febrile episodes and the cost of their treatment and malaria prevention.
Topics: Adult; Animals; Anopheles; Antimalarials; Bedding and Linens; Benin; Child, Preschool; Chloroquine; | 2000 |
Chloroquine-resistant isolates of Plasmodium falciparum with alternative CG2 omega repeat length polymorphisms.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Chloroquine; DNA Primers; DNA, Protozoan; Drug Res | 2000 |
Gametocytemia and infectivity to mosquitoes of patients with uncomplicated Plasmodium falciparum malaria attacks treated with chloroquine or sulfadoxine plus pyrimethamine.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Animals; Anopheles; Antimalarials; Child | 2000 |
Seasonality of Plasmodium vivax and P. falciparum in tribal villages in central India (1987-1995).
Topics: Adolescent; Age Distribution; Analysis of Variance; Antimalarials; Child; Child, Preschool; Chloroqu | 2000 |
Chloroquine resistant malaria.
Topics: Africa South of the Sahara; Anti-Bacterial Agents; Antimalarials; Chloroquine; Doxycycline; Drug Ant | 2000 |
[Malaria imported to Norway 1989-98].
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Disease Notification; | 2000 |
Antimalarial clinical trial protocols--can we avoid risk to patients?
Topics: Adult; Antimalarials; Chloroquine; Drug Resistance; Fatal Outcome; Humans; Malaria, Falciparum; Male | 2000 |
Effect of chloroquine prophylaxis on birthweight and malaria parasite load among pregnant women delivering in a regional hospital in Cameroon.
Topics: Adult; Animals; Birth Weight; Cameroon; Chloroquine; Educational Status; Female; Humans; Infant, Low | 2000 |
In vivo sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine among schoolchildren in rural Uganda: a comparison between 1995 and 1998.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Humans; Malaria, Falciparum; Parasite | 2000 |
In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins.
Topics: Animals; Antimalarials; Artemisinins; Cell Line; Chloroquine; Drug Resistance; Drug Synergism; Human | 2000 |
Chloroquine- and sulfadoxine-pyrimethamine-resistant Falciparum malaria in vivo - a pilot study in rural Zambia.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; F | 2000 |
Prevalence of point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum isolates from India and Thailand: a molecular epidemiologic study.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Dihydropteroa | 2000 |
Hyperreactive malaria in expatriates returning from sub-Saharan Africa.
Topics: Adolescent; Adult; Africa South of the Sahara; Aged; Animals; Antibodies, Protozoan; Antimalarials; | 2000 |
Chemoresistance of P. falciparum in urban areas of Yaounde, Cameroon. Part 1: Surveillance of in vitro and in vivo resistance of Plasmodium falciparum to chloroquine from 1994 to 1999 in Yaounde, Cameroon.
Topics: Adolescent; Adult; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chloroquine; Female; H | 2000 |
Comparative clinical characteristics and response to oral antimalarial therapy of children with and without Plasmodium falciparum hyperparasitaemia in an endemic area.
Topics: Adolescent; Age Factors; Analysis of Variance; Antimalarials; Child; Child, Preschool; Chloroquine; | 2000 |
Chloroquine and desethylchloroquine concentrations in blood cells and plasma from Indian patients infected with sensitive or resistant Plasmodium falciparum.
Topics: Adult; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Drug Resistance; Humans; Ma | 2000 |
Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Drug Resistance; Genes, Prot | 2000 |
Anti-NANP antibody and treatment efficacy in patients with acute uncomplicated falciparum malaria attacks.
Topics: Adolescent; Adult; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Child; Child, | 2000 |
Treatment of uncomplicated Plasmodium falciparum malaria in Myanmar: a clinical decision analysis.
Topics: Antimalarials; Chloroquine; Cost-Benefit Analysis; Decision Support Techniques; Decision Trees; Drug | 2000 |
Prophylactic effect of Malarone against malaria: all good news?
Topics: Antimalarials; Atovaquone; Chloroquine; Drug Combinations; Humans; Malaria, Falciparum; Naphthoquino | 2000 |
Increased plasma levels of histidine and histamine in falciparum malaria: relevance to severity of infection.
Topics: Amino Acids; Antimalarials; Blood-Brain Barrier; Brain; Child; Child, Preschool; Chloroquine; Female | 2000 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Adult; Age Factors; Animals; Child; Chloroquine; DNA Mutational Analysis; Drug Resistance; Genetic M | 2001 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Adult; Age Factors; Animals; Child; Chloroquine; DNA Mutational Analysis; Drug Resistance; Genetic M | 2001 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Adult; Age Factors; Animals; Child; Chloroquine; DNA Mutational Analysis; Drug Resistance; Genetic M | 2001 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Adult; Age Factors; Animals; Child; Chloroquine; DNA Mutational Analysis; Drug Resistance; Genetic M | 2001 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Adult; Age Factors; Animals; Child; Chloroquine; DNA Mutational Analysis; Drug Resistance; Genetic M | 2001 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Adult; Age Factors; Animals; Child; Chloroquine; DNA Mutational Analysis; Drug Resistance; Genetic M | 2001 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Adult; Age Factors; Animals; Child; Chloroquine; DNA Mutational Analysis; Drug Resistance; Genetic M | 2001 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Adult; Age Factors; Animals; Child; Chloroquine; DNA Mutational Analysis; Drug Resistance; Genetic M | 2001 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Adult; Age Factors; Animals; Child; Chloroquine; DNA Mutational Analysis; Drug Resistance; Genetic M | 2001 |
A molecular marker for chloroquine-resistant falciparum malaria.
Topics: Animals; Chloroquine; Drug Resistance; Genetic Markers; Humans; Lysosomes; Malaria, Falciparum; Plas | 2001 |
Research in complex emergencies. Medical Emergency Relief International.
Topics: Chloroquine; Emergencies; Humans; Indonesia; Malaria, Falciparum; Research | 2001 |
Efficacy of chloroquine in febrile Plasmodium falciparum infected children in Mewat region of Haryana.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Fever; Humans; Infant; Mal | 2000 |
Resurgence of malaria in Mumbai--is escalating chloroquine resistance a cause?
Topics: Animals; Chloroquine; Drug Resistance; Humans; Incidence; India; Malaria, Falciparum; Plasmodium fal | 2000 |
Halofantrine in G-6 PD deficiency.
Topics: Aged; Antimalarials; Chloroquine; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria, Falci | 1997 |
Declining chloroquine resistance of Plasmodium falciparum in Lambaréné, Gabon from 1992 to 1998.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Gabon; Humans; In Vitro Techniques; Inhibitory | 2001 |
Resistance of Plasmodium falciparum malaria to chloroquine is widespread in eastern Afghanistan.
Topics: Adolescent; Adult; Afghanistan; Antimalarials; Child; Chloroquine; Drug Resistance; Female; Humans; | 2001 |
Parasitaemia and gametocytaemia after treatment with chloroquine, pyrimethamine/sulfadoxine, and pyrimethamine/sulfadoxine combined with artesunate in young Gambians with uncomplicated malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Child; Chloroquine; Cost-Benefit Analysis; Disease | 2001 |
Evidence for a reduced effect of chloroquine against Plasmodium falciparum in alpha-thalassaemic children.
Topics: alpha-Thalassemia; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Cross-Sectional Stu | 2001 |
[Resistance of Plasmodium falciparum to 3 antimalarials in Turbo (Antioquia, Colombia), 1998].
Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; | 2001 |
[Drug resistance of Plasmodium falciparum in coastal regions of Madagascar].
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Drug Therapy, Combinatio | 2000 |
Pulmonary manifestations in malaria.
Topics: Adult; Animals; Antimalarials; Chloroquine; Female; Humans; Lung Diseases; Malaria, Falciparum; Mala | 2000 |
Variation of incubation time in an in vitro drug susceptibility test of Plasmodium falciparum isolates studied in the Solomon Islands.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Melanesia; Parasitic Sensitivity T | 2001 |
Malaria in Yuanyang, Yunnan, People's Republic of China--new control strategy (1992 -1996).
Topics: Animals; Antimalarials; China; Chloroquine; Communicable Disease Control; Culicidae; DDT; Humans; In | 2000 |
Is reversal of chloroquine resistance ready for the clinic?
Topics: Animals; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Neuro | 2001 |
Assessment of the antimalarial potential of tetraoxane WR 148999.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Cytochrome P-450 Enzyme Inhibitors; Drug Interact | 2000 |
In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites.
Topics: Administration, Oral; Animals; Antimalarials; Cells, Cultured; Chloroquine; Drug Resistance; Female; | 2001 |
Malaria epidemic in Burundi.
Topics: Antimalarials; Artemisinins; Burundi; Chloroquine; Disease Outbreaks; Drug Therapy, Combination; Hum | 2001 |
Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene and its relation to chloroquine resistance in Mozambique.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Codon; Drug Resistance; Female; Genotype; Hum | 2001 |
Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Case-Control Studies; Child, Preschool; C | 2001 |
Brainstem dysfunction: another manifestation of post-malaria neurological syndrome?
Topics: Adult; Antimalarials; Ataxia; Chloroquine; Evoked Potentials, Auditory, Brain Stem; Humans; Malaria, | 2001 |
High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.
Topics: Alleles; Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Clone Cells; Drug R | 2001 |
Sequence polymorphisms in pfcrt are strongly associated with chloroquine resistance in Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Genes, Protozoan; Humans; Malaria, Falciparum; | 2001 |
Use of the DELI-microtest to determine the drug sensitivity of Plasmodium falciparum in Burkina Faso.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Malaria, Falciparum; Mefloquine; Parasitemia; | 2001 |
Malaria diagnosis and treatment administered by teachers in primary schools in Tanzania.
Topics: Adolescent; Antimalarials; Child; Chloroquine; Delivery of Health Care; Female; Humans; Malaria, Fal | 2001 |
[Does the brief treatment with antimalarials favorably influence drug resistance and recurrences?].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Malaria, | 2001 |
Analysis of pfcrt point mutations and chloroquine susceptibility in isolates of Plasmodium falciparum.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistan | 2001 |
Subacute clinical forms of Plasmodium falciparum malaria in travelers receiving chloroquine-proguanil prophylaxis.
Topics: Adult; Africa; Aged; Animals; Antimalarials; Chemoprevention; Chloroquine; Drug Therapy, Combination | 2001 |
Protein tyrosine kinase activity in human malaria parasite Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Enzyme Inhibitors; Humans; Kinetics; Malaria, Falciparum; Plasm | 2000 |
Investigation of malaria prevalence at National Thermal Power Corporation, Shaktinagar, Sonbhadra District (Uttar Pradesh), India.
Topics: Animals; Antimalarials; Chloroquine; Culicidae; Humans; India; Industry; Insect Vectors; Malaria, Fa | 2000 |
HIV infection may adversely affect clinical response to chloroquine therapy for uncomplicated malaria in children.
Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Antimalarials; Child; Child, Preschool; Ch | 2001 |
Ferrocene-chloroquine analogues as antimalarial agents: in vitro activity of ferrochloroquine against 103 Gabonese isolates of Plasmodium falciparum.
Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Ferrous Compounds; Hu | 2001 |
Can treatment of P. vivax lead to a unexpected appearance of falciparum malaria?
Topics: Adult; Animals; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Plasm | 2001 |
Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of Plasmodium falciparum-infected erythrocytes that protect against placental parasitemia.
Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Cell Adhesion; Chloroquine; Chon | 2001 |
Antimalarial t-butylperoxyamines.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Malar | 2001 |
Death from malaria following inappropriate chemoprophylaxis.
Topics: Africa; Animals; Antimalarials; Centers for Disease Control and Prevention, U.S.; Chemoprevention; C | 2001 |
Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria.
Topics: Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Genotype; Humans; Infant; Malaria, F | 2001 |
Plasmodium falciparum: linkage disequilibrium between loci in chromosomes 7 and 5 and chloroquine selective pressure in Northern Nigeria.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Child; Child, Preschool; Chloroquine; Dru | 2001 |
The T76 mutation in the pfcrt gene of Plasmodium falciparum and clinical chloroquine resistance phenotypes in Papua, Indonesia.
Topics: Adult; Alleles; Animals; Antigens, Protozoan; Antimalarials; Child; Chloroquine; Drug Resistance; Ge | 2001 |
Plasmodium falciparum pfcrt and pfmdr1 polymorphisms are associated with the pfdhfr N108 pyrimethamine-resistance mutation in isolates from Ghana.
Topics: Adolescent; Adult; Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; DNA, Prot | 2001 |
Prevalence of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum isolates from southern Mauritania.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Dihydropteroate Syn | 2001 |
[Evaluation of efficacy and tolerance of amodiaquine versus chloroquine in the treatment of uncomplicated malaria outbreak in children of Gabon].
Topics: Adolescent; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Femal | 2001 |
Subacute malaria due to Plasmodium falciparum and the role of polymerase chain reaction.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Plasmodium falciparum; Polymerase | 2001 |
History and importance of antimalarial drug resistance.
Topics: Africa; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; History, 20th Century; Histo | 2001 |
Detection of histidine rich protein 2 and panmalarial ICT Malaria Pf/Pv test antigens after chloroquine treatment of uncomplicated falciparum malaria does not reliably predict treatment outcome in eastern Indonesia.
Topics: Antigens, Protozoan; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Infant, Ne | 2001 |
Allelic variation in the cg2 gene does not correlate with chloroquine resistance among Indian Plasmodium falciparum isolates.
Topics: Alleles; Amino Acid Sequence; Animals; Antimalarials; Base Sequence; Chloroquine; DNA, Protozoan; Dr | 2001 |
Plasmodium falciparum: pfcrt and DHFR mutations are associated with failure of chloroquine plus proguanil prophylaxis in travelers.
Topics: Animals; Antimalarials; Chloroquine; Drug Therapy, Combination; Humans; Malaria, Falciparum; Membran | 2001 |
Psychiatric complications of malaria: a case report.
Topics: Acute Disease; Adult; Antimalarials; Brain; Chloroquine; Chronic Disease; Humans; Malaria, Falciparu | 2001 |
Malaria remains a military medical problem.
Topics: Adult; Animals; Antimalarials; Atovaquone; Chloroquine; Drug Combinations; Global Health; Humans; Ke | 2001 |
Molecular markers for chloroquine-resistant Plasmodium falciparum malaria in Thailand and Laos.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Chloroquine; Drug Resistance; Genetic Mar | 2001 |
Epidemiologic investigations of a malaria outbreak in northern Delhi area.
Topics: Adolescent; Adult; Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroquine; Disease | 2001 |
Sustained release implants of chloroquine phosphate for possible use in chemoprophylaxis of malaria.
Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Dose-Response Relationship, Drug; Drug Implant | 2001 |
Asexual erythrocytic forms of Plasmodium falciparum in asymptomatic American and Korean soldiers serving in Vietnam.
Topics: Animals; Antimalarials; Australia; Chloroquine; Erythrocytes; Humans; Korea; Malaria, Falciparum; Mi | 1967 |
Weekly chloroquine prophylaxis and the effect on maternal haemoglobin status at delivery.
Topics: Adult; Anemia; Animals; Antimalarials; Chloroquine; Female; Hemoglobins; Humans; Labor, Obstetric; M | 2002 |
Mapping of a Plasmodium falciparum pfcrt K76T mutation: a useful strategy for controlling chloroquine resistance in Madagascar.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Madagascar; Malaria, Falciparum; Membr | 2002 |
An in-vivo study of falciparum malaria sensitivity to Chloroquine in unstable malaria endemic area of central Ethiopia.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Ethiopia; Female; H | 1999 |
Do azoles and chloroquine share similar mechanisms of antimalarial action?
Topics: Animals; Antimalarials; Azoles; Chloroquine; Clotrimazole; Humans; Malaria, Falciparum; Parasitic Se | 2002 |
[Management of child fever in the battle against malaria in Brazzaville].
Topics: Amodiaquine; Antimalarials; Asthenia; Child, Preschool; Chills; Chloroquine; Congo; Diarrhea; Fever; | 2002 |
Chronic persistent hemolysis in an infant: can we afford to forget malaria as a cause?
Topics: Anemia, Hemolytic; Chloroquine; Chronic Disease; Humans; Infant; Infectious Disease Transmission, Ve | 2002 |
Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana.
Topics: Age Factors; Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Resistance; Female; Follow- | 2002 |
[In vitro sensitivity of Plasmodium falciparum to chloroquine, piperaquine, pyronaridine and artesunate in Yuxi prefecture of Yunnan province].
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloro | 1998 |
Resistant malaria in a neonate.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Resistance, Multiple; Drug Therapy, Combi | 2002 |
A longitudinal study to monitor chloroquine-resistant P. falciparum malaria in Bokajan and Manja PHC areas of Karbi Anglong District, Assam.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Longitudinal Studies; Malaria, Falciparum; Pla | 1992 |
Treatment of chloroquine-resistant malaria in monkeys with a drug combination that reverses resistance in vitro.
Topics: Animals; Aotus trivirgatus; Calcium Channel Blockers; Chloroquine; Drug Combinations; Drug Resistanc | 1992 |
Malaria--general management as recommended by WHO.
Topics: Adult; Antimalarials; Child; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Cerebral; Malar | 1992 |
Death from a severe case of Plasmodium falciparum in a Canadian.
Topics: Adult; Animals; Antimalarials; Cause of Death; Chloroquine; Drug Combinations; Female; Humans; Malar | 1992 |
Sensitivity status of Plasmodium falciparum to chloroquine, amodiaquine, quinine, mefloquine and sulfadoxine/pyrimethamine in a tribal population of District Sundargarh, Orissa.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, | 1992 |
Persistence of low levels of Plasmodium falciparum resistance to chloroquine in the autochthonous population of the Central African Republic.
Topics: Animals; Central African Republic; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Ma | 1992 |
[Alteration in resistance of Plasmodium falciparum to chloroquine after cessation of chloroquine medication for twelve years].
Topics: Animals; Chloroquine; Drug Resistance; In Vitro Techniques; Longitudinal Studies; Malaria, Falciparu | 1992 |
[Treatment of malaria in children in France].
Topics: Antimalarials; Child; Chloroquine; France; Humans; Malaria, Cerebral; Malaria, Falciparum; Mefloquin | 1992 |
[In vivo chemosensitivity of Plasmodium falciparum to chloroquine in Burkina Faso: development of resistance 1988-1990].
Topics: Animals; Burkina Faso; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria, Falci | 1992 |
Importance of mean parasite clearance time and recrudescence time and their role in gradation of Plasmodium falciparum resistance.
Topics: Adolescent; Adult; Age Factors; Animals; Child; Child, Preschool; Chloroquine; Drug Evaluation; Drug | 1992 |
Chloroquine and proguanil prophylaxis in travellers to Kenya.
Topics: Chloroquine; Health Education; Humans; Kenya; Malaria, Falciparum; Proguanil; Travel | 1992 |
Chloroquine and proguanil prophylaxis in travellers to Kenya.
Topics: Chloroquine; Humans; Kenya; Malaria, Falciparum; Patient Compliance; Proguanil; Travel | 1992 |
Plasmodium falciparum: in vitro characterization and human infectivity of a cloned line.
Topics: Amino Acid Sequence; Animals; Anopheles; Antigens, Protozoan; Antigens, Surface; Base Sequence; Chlo | 1992 |
Long-term course of antimalarial maculopathy after cessation of treatment.
Topics: Chloroquine; Follow-Up Studies; Humans; Hydroxychloroquine; Longitudinal Studies; Macula Lutea; Mala | 1992 |
Evaluating the efficacy of chloroquine in febrile Guinean children infected with Plasmodium falciparum by a simplified in vivo test.
Topics: Animals; Blood; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Guinea; Humans; Infan | 1992 |
[Malaria and pregnancy].
Topics: Adult; Chloroquine; Female; Fetal Death; Humans; Malaria, Falciparum; Malaria, Vivax; Pregnancy; Pre | 1992 |
[Stability and chemosensitivity of Plasmodium falciparum to chloroquine in 1990 and 1991 in Ankazobe, a village in high plateau Madagascar].
Topics: Animals; Chloroquine; Drug Resistance; Humans; Madagascar; Malaria, Falciparum; Plasmodium falciparu | 1992 |
Rapid in vivo detection of chloroquine resistance by the Quantitative Buffy Coat Malaria Diagnosis System.
Topics: Animals; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum; Sensitivi | 1992 |
In vitro activity of halofantrine and its relationship to other standard antimalarial drugs against African isolates and clones of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Phenanthr | 1992 |
Imported malaria in the Bronx: review of 51 cases recorded from 1986 to 1991.
Topics: Adolescent; Adult; Africa, Western; Animals; Antimalarials; Asia, Western; Chi-Square Distribution; | 1992 |
Antimalarial drug sensitivity patterns in the western province of Zambia. Implications for the management of primary health care (PHC).
Topics: Adolescent; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans; Malaria, | 1992 |
Problem of antimalarial drug resistance in Plasmodium falciparum in Mizoram.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Plasmodium | 1992 |
The in vitro and in vivo antimalarial activity of some Mannich bases derived from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol, 2-(7'-trifluoromethyl-quinolin-4'-ylamino)phenol, and 4'-chloro-5-(7''-trifluoromethylquinolin-4''-ylamino)biphen
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Hypoxanthines; Malaria, Falciparum; Male; Mann | 1992 |
Effectiveness of long-term malaria chemoprophylaxis among French expatriates residing in Rwanda.
Topics: Antimalarials; Chloroquine; France; Humans; Malaria, Falciparum; Proguanil; Rwanda | 1992 |
New trends in chloroquine efficacy in the treatment of malaria: significance of low (scanty) parasitaemia in an endemic area, with emerging chloroquine-resistant P. falciparum.
Topics: Adult; Animals; Child; Child, Preschool; Chloroquine; Chronic Disease; Drug Resistance; Female; Huma | 1992 |
Chloroquine resistant Plasmodium falciparum malaria in Calcutta.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Humans; India; Mala | 1992 |
Malariometric survey in Keoudom District, Laos: sensitivity of Plasmodium falciparum to anti-malarials and automedication with chloroquine.
Topics: Adolescent; Adult; Animals; Antibodies, Protozoan; Child; Child, Preschool; Chloroquine; Disease Res | 1992 |
Decrease of malaria morbidity with community participation in central Java.
Topics: Adult; Child; Child, Preschool; Chloroquine; Health Education; Humans; Indonesia; Malaria, Falciparu | 1992 |
Efficacies of chloroquine, pyrimethamine/sulphadoxine and pyrimethamine/sulphalene against P. falciparum in northeastern Nigeria.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Humans; Incidence; Infant; | 1992 |
Chloroquine resistance of Plasmodium falciparum in Bukumbi, Tanzania. An in vivo study.
Topics: Child, Preschool; Chloroquine; Classification; Drug Resistance; Humans; Infant; Malaria, Falciparum; | 1992 |
Pathology of falciparum malaria in Vietnam.
Topics: Adult; Aged; Aged, 80 and over; Brain; Chloroquine; Female; Humans; Malaria, Cerebral; Malaria, Falc | 1992 |
In vivo and in vitro response of Plasmodium falciparum to chloroquine in pregnant women in Kilifi district, Kenya.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Female; Hospitals, District; Humans; Kenya; Malaria, F | 1992 |
Proposals for a new therapeutic strategy for simple Plasmodium falciparum malaria attacks in Cameroon.
Topics: Administration, Oral; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Child, | 1992 |
Assessment of chloroquine resistance of Plasmodium falciparum in children of Wad Medani (Central Sudan).
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; In Vitro | 1992 |
[Resistance of Plasmodium falciparum to the chloroquine-proguanil combination. A case from Benin].
Topics: Adult; Benin; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Malaria, F | 1992 |
Multi-drug resistant falciparum malaria in Cameroon in 1987-1988. I. Stable figures of prevalence of chloroquine- and quinine-resistant isolates in the original foci.
Topics: Animals; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria, F | 1992 |
Treatment of chloroquine-resistant malaria in African children: a cost-effectiveness analysis.
Topics: Africa; Amodiaquine; Animals; Antimalarials; Child, Preschool; Chloroquine; Cost-Benefit Analysis; D | 1992 |
Unexpected response to treatment of falciparum malaria illness.
Topics: Adult; Antimalarials; Chloroquine; Doxycycline; Drug Resistance; Drug Therapy, Combination; Humans; | 1992 |
Malaria and pregnancy in Cameroonian women. Effect of pregnancy on Plasmodium falciparum parasitemia and the response to chloroquine.
Topics: Cameroon; Chloroquine; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Malaria, Falci | 1992 |
Merocyanine 540-sensitized photoinactivation of human erythrocytes parasitized by Plasmodium falciparum.
Topics: Animals; Chloroquine; Drug Resistance; Erythrocytes; Humans; In Vitro Techniques; Malaria, Falciparu | 1992 |
Susceptibility of Plasmodium falciparum strains to mefloquine in an urban area in Senegal.
Topics: Adolescent; Adult; Aminoquinolines; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Hu | 1992 |
Acute renal failure in severe chloroquine resistant falciparum malaria.
Topics: Acute Kidney Injury; Adult; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; | 1992 |
Type RI resistance to halofantrine in West Africa.
Topics: Animals; Antimalarials; Biological Availability; Chloroquine; Cote d'Ivoire; Drug Resistance; Follow | 1991 |
Failure of chloroquine and proguanil prophylaxis in travellers to Kenya.
Topics: Animals; Chloroquine; Female; Humans; Kenya; Malaria, Falciparum; Proguanil; Travel | 1991 |
Congenital malaria with chloroquine resistance.
Topics: Chloroquine; Drug Resistance; Female; Humans; Infant, Newborn; Malaria, Falciparum; Quinine | 1991 |
West African malaria.
Topics: Chloroquine; Female; Humans; Immunity, Innate; Malaria, Falciparum; Male; Middle Aged; Military Pers | 1991 |
[Malaria in the republic of São Tomé and Principe. Epidemiologic evaluation and chemoresistance of P. falciparum].
Topics: Age Factors; Animals; Antimalarials; Atlantic Islands; Child; Child, Preschool; Chloroquine; Drug Re | 1991 |
Simulation of kinetic data on the influx and efflux of chloroquine by erythrocytes infected with Plasmodium falciparum. Evidence for a drug-importer in chloroquine-sensitive strains.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Chloroquine; Diffusion; Drug Resistance; | 1991 |
Severe falciparum malaria (21 cases).
Topics: Adolescent; Adult; Child, Preschool; Chloroquine; Exchange Transfusion, Whole Blood; Female; Humans; | 1991 |
Chloroquine resistant P. falciparum malaria in Arunachal Pradesh.
Topics: Adolescent; Adult; Animals; Child; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; | 1991 |
Malaria prophylaxis.
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Trav | 1991 |
Chloroquine resistant Plasmodium falciparum malaria in Rajasthan.
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Plasmodium falciparum | 1991 |
[Malaria of the pregnant woman and the newborn].
Topics: Adult; Animals; Cesarean Section; Chloroquine; Female; Fetal Diseases; Humans; Infant, Newborn; Mala | 1991 |
A study of current practices in the treatment of malaria in industrial complexes in India.
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum | 1991 |
Resistant falciparum malaria in an endemic area of Allahabad (U.P.).
Topics: Animals; Chloroquine; Drug Resistance; Humans; India; Malaria, Falciparum; Plasmodium falciparum | 1991 |
In vitro and in vivo potentiation of chloroquine against malaria parasites by an enantiomer of amlodipine.
Topics: Amlodipine; Animals; Chloroquine; Drug Synergism; Erythrocytes; Female; Malaria, Falciparum; Mice; N | 1991 |
[Malaria of importation in the child: epidemiological, clinical and therapeutic analysis. Apropos of 70 cases observed in a pediatric hospital in Paris].
Topics: Africa; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Malaria; Malaria, Fal | 1991 |
An in vivo chloroquine sensitivity study in relation to low transmission potential and imported malaria in Kerala.
Topics: Animals; Chloroquine; Commerce; Drug Resistance; Humans; India; Malaria, Falciparum; Plasmodium falc | 1991 |
Changing response of Plasmodium falciparum to chloroquine in West Bengal during 1980-1988.
Topics: Animals; Chloroquine; Drug Administration Schedule; Drug Resistance; Humans; India; Malaria, Falcipa | 1991 |