chloroquine has been researched along with Macular Degeneration in 24 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine diphosphate has been used in the treatment of various rheumatic diseases, including rheumatoid arthritis." | 7.74 | Chloroquine-induced bull's eye maculopathy in rheumatoid arthritis: related to disease duration? ( Kochen, JA; Laurindo, IM; Maia, OO; Morita, C; Shinjo, SK; Takahashi, WY; Tizziani, VA, 2007) |
| "Chloroquine diphosphate has been used in the treatment of various rheumatic diseases, including rheumatoid arthritis." | 3.74 | Chloroquine-induced bull's eye maculopathy in rheumatoid arthritis: related to disease duration? ( Kochen, JA; Laurindo, IM; Maia, OO; Morita, C; Shinjo, SK; Takahashi, WY; Tizziani, VA, 2007) |
| "A 59-year-old housewife took a daily dosage of 250 mg chloroquine for her rheumatoid arthritis over a period of 5 years up to a total dose of 450 g." | 3.69 | [Chloroquine-induced bull's eye maculopathy without electrophysiologic changes]. ( Cursiefen, C; Grunert, U; Jünemann, A, 1997) |
| " A higher dosage per kg body mass, long therapy duration, presence of keratopathy and renal or hepatic dysfunction are probably associated with an increased risk to develop a maculopathy/retinopathy." | 2.45 | [Retinal damage by (hydroxy)chloroquine intake: published evidence for an efficient ophthalmological follow-up]. ( Pluta, JP; Rüther, K, 2009) |
| " The risk of this severe, irreversible ophthalmological complication significantly increases with duration of treatment (> 5 years) and dosage of medication (for CQ > 2." | 1.48 | [Chloroquine retinopathy]. ( Lavrijsen, APM; Nguyen, AL; Tan, AN, 2018) |
| "Chloroquine-induced maculopathy may progress years after drug cessation and an apparent period of visual stability." | 1.46 | Delayed progression of bull's eye maculopathy. ( Jain, NG; Jain, S, 2017) |
| " Established risk factors are duration and dosage of treatment while the involvement of genetic factors contributing to toxic maculopathy is largely unclear." | 1.42 | Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy). ( Bergholz, R; Grassmann, F; Jägle, H; Mändl, J; Ruether, K; Weber, BH, 2015) |
| "Chloroquine retinopathy is a well-documented toxic manifestation of a commonly used systemic medication." | 1.27 | Progressive chloroquine retinopathy. ( Brucker, AJ; Campbell, C; Cobbs, W; Sassani, JW, 1983) |
| "A case of maculopathy mimicking chloroquine toxicity without exposure to the drug is described." | 1.26 | Retinal vascular changes in bull's eye maculopathy. ( Chopdar, A, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (45.83) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Rickmann, A | 1 |
| Al-Nawaiseh, S | 1 |
| Ramirez, L | 1 |
| Röhrig, S | 1 |
| Ladewig, M | 1 |
| Szurman, P | 1 |
| Szurman, G | 1 |
| Handzel, DM | 1 |
| Romanou-Papadopoulou, V | 1 |
| Briesen, S | 1 |
| Jain, S | 1 |
| Jain, NG | 1 |
| Nguyen, AL | 1 |
| Tan, AN | 1 |
| Lavrijsen, APM | 1 |
| Grassmann, F | 1 |
| Bergholz, R | 1 |
| Mändl, J | 1 |
| Jägle, H | 1 |
| Ruether, K | 1 |
| Weber, BH | 1 |
| Zhan, J | 1 |
| He, J | 1 |
| Zhou, Y | 1 |
| Wu, M | 1 |
| Liu, Y | 1 |
| Shang, F | 1 |
| Zhang, X | 1 |
| Szatmári-Tóth, M | 1 |
| Kristóf, E | 1 |
| Veréb, Z | 1 |
| Akhtar, S | 1 |
| Facskó, A | 1 |
| Fésüs, L | 1 |
| Kauppinen, A | 1 |
| Kaarniranta, K | 1 |
| Petrovski, G | 1 |
| Kunavisarut, P | 1 |
| Chavengsaksongkram, P | 1 |
| Rothova, A | 1 |
| Pathanapitoon, K | 1 |
| Pluta, JP | 1 |
| Rüther, K | 1 |
| SMITH, JL | 1 |
| ROBERTSON, PR | 1 |
| PENNER, R | 1 |
| SOMERS, K | 1 |
| Shinjo, SK | 1 |
| Maia, OO | 1 |
| Tizziani, VA | 1 |
| Morita, C | 1 |
| Kochen, JA | 1 |
| Takahashi, WY | 1 |
| Laurindo, IM | 1 |
| Vanheesbeke, A | 1 |
| Sassani, JW | 1 |
| Brucker, AJ | 1 |
| Cobbs, W | 1 |
| Campbell, C | 1 |
| Paulus, HE | 1 |
| Cursiefen, C | 1 |
| Grunert, U | 1 |
| Jünemann, A | 1 |
| Edwards, AC | 1 |
| Meredith, TJ | 1 |
| Sowton, E | 1 |
| Chopdar, A | 1 |
| Bonnet, M | 1 |
| Leroy, D | 1 |
| Trojan, HJ | 1 |
| Meier-Ruge, W | 1 |
| Deutman, AF | 1 |
| van Lith, GH | 1 |
| Obikili, AG | 1 |
3 reviews available for chloroquine and Macular Degeneration
| Article | Year |
|---|---|
[Progressive maculopathy despite discontinuation of chloroquine treatment-multimodal imaging and review of the literature].
Topics: Chloroquine; Humans; Macular Degeneration; Multimodal Imaging; Prognosis; Retinal Diseases | 2020 |
[Retinal damage by (hydroxy)chloroquine intake: published evidence for an efficient ophthalmological follow-up].
Topics: Antimalarials; Chloroquine; Diagnostic Techniques, Ophthalmological; Dose-Response Relationship, Dru | 2009 |
[Retinal pigment epithelium--the point about safety of antimalarial agents].
Topics: Aged; Animals; Antimalarials; Chloroquine; Cisplatin; Humans; Hydroxychloroquine; Macular Degenerati | 2007 |
21 other studies available for chloroquine and Macular Degeneration
| Article | Year |
|---|---|
[Visual loss under chloroquine treatment-and not (only) due to bull's eye maculopathy!]
Topics: Blindness; Chloroquine; Humans; Macular Degeneration; Vision Disorders | 2021 |
Delayed progression of bull's eye maculopathy.
Topics: Aftercare; Aged; Antirheumatic Agents; Chloroquine; Disease Progression; Electroretinography; Female | 2017 |
[Chloroquine retinopathy].
Topics: Antirheumatic Agents; Chloroquine; Female; Humans; Hydroxychloroquine; Lupus Erythematosus, Discoid; | 2018 |
Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy).
Topics: Adult; Aged; Alleles; Antirheumatic Agents; ATP-Binding Cassette Transporters; Chloroquine; Female; | 2015 |
Crosstalk Between the Autophagy-Lysosome Pathway and the Ubiquitin-Proteasome Pathway in Retinal Pigment Epithelial Cells.
Topics: Autophagy; Cell Line; Chloroquine; Epithelial Cells; Humans; Lysosomes; Macular Degeneration; Protea | 2016 |
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.
Topics: Adenine; Autophagy; Biomarkers; Cell Line; Chloroquine; Coculture Techniques; Culture Media, Serum-F | 2016 |
Screening for chloroquine maculopathy in populations with uncertain reliability in outcomes of automatic visual field testing.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Child; Chloroquine; Electroretinog | 2016 |
Chloroquine macular degeneration.
Topics: Blindness; Chloroquine; Disease; Humans; Macula Lutea; Macular Degeneration; Retinal Degeneration | 1962 |
ANOTHER CASE OF MACULAR DEGENERATION DUE TO CHLOROQUINE.
Topics: Chloroquine; Macula Lutea; Macular Degeneration; Ophthalmology; Toxicology | 1963 |
Bilateral macular degeneration associated with chloroquine therapy.
Topics: Chloroquine; Disease; Humans; Macula Lutea; Macular Degeneration; Retinal Degeneration | 1962 |
Chloroquine-induced bull's eye maculopathy in rheumatoid arthritis: related to disease duration?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Disease Progression; Female; | 2007 |
Progressive chloroquine retinopathy.
Topics: Chloroquine; Fluorescein Angiography; Follow-Up Studies; Humans; Macular Degeneration; Malaria; Male | 1983 |
An overview of benefit/risk of disease modifying treatment of rheumatoid arthritis as of today.
Topics: Arthritis, Rheumatoid; Azathioprine; Chloroquine; Cyclophosphamide; Female; Gold; Humans; Hydroxychl | 1982 |
[Chloroquine-induced bull's eye maculopathy without electrophysiologic changes].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Dose-Response Relationship, Drug; Drug Adm | 1997 |
Complete heart block due to chronic chloroquine toxicity managed with permanent pacemaker.
Topics: Adult; Chloroquine; Heart Block; Humans; Macular Degeneration; Male; Pacemaker, Artificial | 1978 |
Retinal vascular changes in bull's eye maculopathy.
Topics: Chloroquine; Female; Fluorescein Angiography; Humans; Macular Degeneration; Middle Aged; Retinal Deg | 1976 |
[The "bull's eye" maculopathy (symptomatology)].
Topics: Chloroquine; Humans; Macular Degeneration; Retinal Degeneration | 1976 |
[Eye complications in the long-term treatment with chloroquin. Study carried out in Togo].
Topics: Cataract; Chloroquine; Corneal Opacity; Eye Diseases; Female; Humans; Macular Degeneration; Malaria; | 1975 |
[Toxic macular injuries].
Topics: Animals; Cats; Chloroquine; Dogs; Humans; Macula Lutea; Macular Degeneration; Phenothiazines; Retina | 1975 |
[Differential diagnosis of the "bull's eye" macula].
Topics: Chloroquine; Diagnosis, Differential; Female; Humans; Macular Degeneration; Male; Retinal Degenerati | 1975 |
A type of macular degeneration in adult Nigerians; a possible role of chloroquine.
Topics: Adult; Chloroquine; Female; Humans; Macular Degeneration; Malaria; Male; Nigeria; Pterygium; Retrosp | 1990 |