chloroquine has been researched along with Lymphoma in 17 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| " When HSB-2 T lymphoma cells were mixed with normal human bone marrow and incubated with 3A1-PAP and 100 microM chloroquine, approximately 3 logs of clonogenic T cells could be eliminated from a 20-fold excess of bone marrow." | 3.68 | Elimination of malignant clonogenic T cells from human bone marrow using chemoimmunoseparation with 2'-deoxycoformycin, deoxyadenosine and an immunotoxin. ( Haleen, A; Haynes, BF; Houston, LL; Kurtzberg, J; Montgomery, RB; Olsen, GA; Peters, WP; Ramakrishnan, S; Rhinehardt-Clark, A; Smith, CA, 1990) |
| "Transferrin degradation was not found, which leads us to suggest a process of 'acid flushing' for the dissociation of iron from transferrin without the involvement of endosome-lysosome fusion." | 1.27 | Iron metabolism of established human hematopoietic cell lines in vitro. ( Forsbeck, K; Nilsson, K, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (52.94) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Niesen, J | 1 |
| Hehmann-Titt, G | 1 |
| Woitok, M | 1 |
| Fendel, R | 1 |
| Barth, S | 1 |
| Fischer, R | 1 |
| Stein, C | 1 |
| Turno-Kręcicka, A | 1 |
| Tomczyk-Socha, M | 1 |
| Zimny, A | 1 |
| Delage, B | 1 |
| Luong, P | 1 |
| Maharaj, L | 1 |
| O'Riain, C | 1 |
| Syed, N | 1 |
| Crook, T | 1 |
| Hatzimichael, E | 1 |
| Papoudou-Bai, A | 1 |
| Mitchell, TJ | 1 |
| Whittaker, SJ | 1 |
| Cerio, R | 1 |
| Gribben, J | 1 |
| Lemoine, N | 1 |
| Bomalaski, J | 1 |
| Li, CF | 1 |
| Joel, S | 1 |
| Fitzgibbon, J | 1 |
| Chen, LT | 1 |
| Szlosarek, PW | 1 |
| HIRAKI, K | 1 |
| KIMURA, I | 1 |
| VANBREMEERSCH, F | 1 |
| Amaravadi, RK | 1 |
| Yu, D | 1 |
| Lum, JJ | 1 |
| Bui, T | 1 |
| Christophorou, MA | 1 |
| Evan, GI | 1 |
| Thomas-Tikhonenko, A | 1 |
| Thompson, CB | 1 |
| Forsbeck, K | 1 |
| Nilsson, K | 1 |
| Arnold, AM | 1 |
| Whitehouse, JM | 1 |
| Delhaes, L | 1 |
| Abessolo, H | 1 |
| Biot, C | 1 |
| Berry, L | 1 |
| Delcourt, P | 1 |
| Maciejewski, L | 1 |
| Brocard, J | 1 |
| Camus, D | 1 |
| Dive, D | 1 |
| Wurm, K | 1 |
| Selvan, RS | 1 |
| Nagarkatti, PS | 1 |
| Nagarkatti, M | 1 |
| Augustine, EC | 1 |
| Kensinger, RS | 1 |
| Montgomery, RB | 1 |
| Kurtzberg, J | 1 |
| Rhinehardt-Clark, A | 1 |
| Haleen, A | 1 |
| Ramakrishnan, S | 2 |
| Olsen, GA | 1 |
| Peters, WP | 1 |
| Smith, CA | 1 |
| Haynes, BF | 1 |
| Houston, LL | 2 |
| Bikoff, EK | 1 |
| Yu, H | 1 |
| Eckhardt, LA | 1 |
| Uckun, FM | 1 |
| Krauze, J | 1 |
| Ota, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Tumor Hypoxia With 18F-EF5 PET in Recurrent or Metastatic Clear Cell Ovarian Cancer[NCT01881451] | 5 participants (Actual) | Observational | 2013-08-31 | Terminated (stopped due to Due to slow accrual and access to the study drug.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chloroquine and Lymphoma
| Article | Year |
|---|---|
[Sarcoidosis therapy and its problems today].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents; Antineoplasti | 1978 |
Multiple combination therapy in cancer chemotherapy in Japan.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chloroquine; Cyclophosphamide; Cytarabine; Drug | 1969 |
15 other studies available for chloroquine and Lymphoma
| Article | Year |
|---|---|
A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Chloroquine; ErbB Receptors; Granzymes; HEK293 Cells; Hu | 2016 |
Progressive outer retinal necrosis syndrome in the course of systemic lupus erythematosus.
Topics: Adult; Antiviral Agents; Central Nervous System Neoplasms; Chloroquine; Chorioretinitis; Fatal Outco | 2016 |
Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis.
Topics: Apoptosis; Arginine; Argininosuccinate Synthase; Autophagy; Caspases; Chloroquine; DNA Methylation; | 2012 |
STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. IV. EFFECTS OF CHLOROQUINE ON MALIGNANT LYMPHOMAS.
Topics: Chloroquine; Fibroblasts; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lympho | 1964 |
[CUTANEOUS LYMPHOCYTOMAS].
Topics: Chloroquine; Humans; Lymphoma; Methylprednisolone; Neoplasms; Pathology; Pseudolymphoma; Skin Neopla | 1965 |
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma.
Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Genes | 2007 |
Iron metabolism of established human hematopoietic cell lines in vitro.
Topics: Ammonium Chloride; Cell Line; Chloroquine; Endocytosis; Erythrocytes; Ferritins; Heme; Humans; Iron; | 1983 |
Interaction of VP16-213 with the DNA repair antagonist chloroquine.
Topics: Animals; Chloroquine; DNA Repair; Drug Interactions; Etoposide; Female; Lymphoma; Mice; Mice, Inbred | 1982 |
In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites.
Topics: Administration, Oral; Animals; Antimalarials; Cells, Cultured; Chloroquine; Drug Resistance; Female; | 2001 |
Role of IL-2, IL-4 and IL-6 in the growth and differentiation of tumor-specific CD4+ T helper and CD8+ T cytotoxic cells.
Topics: Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; Antigens, Differentiation, T-Lymphocyte; | 1990 |
Endocytosis and degradation of ovine prolactin by Nb2 lymphoma cells: characterization and effects of agents known to alter prolactin-induced mitogenesis.
Topics: Amiloride; Animals; Calcimycin; Cell Division; Cell Membrane; Chloroquine; Endocytosis; Kinetics; Le | 1990 |
Elimination of malignant clonogenic T cells from human bone marrow using chemoimmunoseparation with 2'-deoxycoformycin, deoxyadenosine and an immunotoxin.
Topics: Antiviral Agents; Bone Marrow; Cell Line; Cell Separation; Chloroquine; Deoxyadenosines; Hematopoiet | 1990 |
T cell recognition of endogenous IgG2a expressed in B lymphoma cells.
Topics: Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; B-Lymphocytes; Chloroquine; Histocompatib | 1988 |
Increased efficiency in selective elimination of leukemia cells by a combination of a stable derivative of cyclophosphamide and a human B-cell-specific immunotoxin containing pokeweed antiviral protein.
Topics: Antibodies, Monoclonal; Antiviral Agents; B-Lymphocytes; Bone Marrow Cells; Cell Line; Cell Survival | 1985 |
[Loefgren's syndrome in a 37-year-old woman].
Topics: Adrenal Cortex Hormones; Adult; Chloroquine; Drug Therapy, Combination; Erythema Nodosum; Female; Hu | 1973 |