chloroquine has been researched along with Lung Neoplasms in 84 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Urethane-induced lung carcinogenesis led to more M2 macrophage phenotype and increased abnormal angiogenesis concomitant with the upregulation of LC3-B and the downregulation of p62." | 5.43 | The M2 macrophages induce autophagic vascular disorder and promote mouse sensitivity to urethane-related lung carcinogenesis. ( Cao, N; Du, GJ; Geng, SN; Guo, ZZ; Han, G; Li, GG; Lin, HH; Ma, XF; Meng, MJ; Zheng, YQ, 2016) |
| "Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment." | 5.43 | Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model. ( Bérubé-Lauzière, Y; Bouchard, G; Bujold, R; Geha, S; Paquette, B; Saucier, C; Therriault, H, 2016) |
| " Combined chloroquine and HDACi treatment abrogates growth of human MPNST xenografts and lung metastases." | 3.77 | Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: potential implications for the treatment of a therapeutic-resistant malignancy. ( Lev, D; Lopez, G; Torres, K, 2011) |
| " Chloroquine, ergotamine, ethaverine and chronic abuse of non-narcotic analgesic drugs seem to be responsible for the drug-induced cutaneous neuro-phospholipidosis, whereas the same condition was found in two patients with metastatic bronchogenic carcinoma and malignant melanoma." | 3.65 | Tumor- and drug-induced cutaneous neuro-phospholipidosis. ( Orfanos, CE; Runne, U, 1975) |
| "CAFs contribute to metastasis process through direct or indirect interaction with tumor cells; however, the underlying mechanism is largely unknown." | 1.62 | Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling. ( Cao, L; Chen, M; Furlong, F; Guo, X; Li, X; Meng, Z; Ren, Y; Wang, L; Wu, X; Xu, K; Zhang, Q; Zheng, S, 2021) |
| " These results reveal that autophagy plays an adverse role in osimertinib cytotoxicity through inducing stem cell-like properties." | 1.51 | Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer. ( Feng, M; He, Y; Hu, C; Jiao, L; Li, L; Lin, C; Lu, C; Wang, Y; Wu, H; Ye, J; Zhang, D; Zhang, K, 2019) |
| "Chloroquine (CQ) has been revealed to exhibit antitumor activity in several human tumors including lung cancer as mono‑ or add‑on therapy." | 1.48 | Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis. ( Cui, H; Han, C; Liu, L; Yu, H; Yue, L; Zhang, C; Zheng, L; Zhu, W, 2018) |
| "Chloroquine (CQ) was used in combination with AP/ES to normalize tumor vessels for sufficient drug/gene delivery to overcome drug resistance in NSCLC cells." | 1.48 | Chloroquine in combination with aptamer-modified nanocomplexes for tumor vessel normalization and efficient erlotinib/Survivin shRNA co-delivery to overcome drug resistance in EGFR-mutated non-small cell lung cancer. ( Chen, H; Gao, Y; Li, Z; Lv, T; Xu, L; Zhang, Y, 2018) |
| " Besides, xenograft experiment showed that combination with autophagy inhibitor potentiated the anti-tumor efficacy of rhArg in vivo." | 1.46 | A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor. ( Cao, Z; Fan, J; Fu, X; Ju, D; Luan, J; Shen, W; Xu, Z; Yang, P; Zhang, X, 2017) |
| "Lung cancer is the leading cause of cancer-related deaths." | 1.46 | Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells. ( Barr, MP; Cardelli, J; Circu, M; El-Osta, H; Mills, G; O'Byrne, K, 2017) |
| "Urethane-induced lung carcinogenesis led to more M2 macrophage phenotype and increased abnormal angiogenesis concomitant with the upregulation of LC3-B and the downregulation of p62." | 1.43 | The M2 macrophages induce autophagic vascular disorder and promote mouse sensitivity to urethane-related lung carcinogenesis. ( Cao, N; Du, GJ; Geng, SN; Guo, ZZ; Han, G; Li, GG; Lin, HH; Ma, XF; Meng, MJ; Zheng, YQ, 2016) |
| "Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment." | 1.43 | Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model. ( Bérubé-Lauzière, Y; Bouchard, G; Bujold, R; Geha, S; Paquette, B; Saucier, C; Therriault, H, 2016) |
| "Chloroquine (CQ) is a widely used antimalarial drug with emerging potential in anticancer therapies due to its apparent inhibitory effects on CXCR4 chemokine receptor, autophagy, and cholesterol metabolism." | 1.43 | Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis. ( Li, J; Oupický, D; Sleightholm, RL; Xie, Y; Yu, F, 2016) |
| "Quercetin treatment dose-dependently decreased the p62 protein expression and increased GFP-LC3B." | 1.42 | Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. ( Eo, SK; Lee, JH; Moon, JH; Park, SY, 2015) |
| "In addition, LY2603618-treated lung cancer cells transitioned from LC3-I to LC3-II, a hallmark of autophagy." | 1.40 | The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. ( Cui, YJ; Fei, HR; Li, ZM; Sun, BL; Sun, YK; Wang, FZ; Wang, XY; Yang, XY; Zhang, JG, 2014) |
| "Chloroquine (CQ) is an antimalarial drug and late-stage inhibitor of autophagy currently FDA-approved for use in the treatment of rheumatoid arthritis and other autoimmune diseases." | 1.40 | Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent. ( Cummings, C; Gamez, G; Gidan, F; Hernandez, A; Maycotte, P; Menke, C; Morgan, MJ; Morgan, S; Staskiewicz, L; Thorburn, A; Thorburn, J, 2014) |
| " NVP-BEZ235 (BEZ235) is a novel, orally bioavailable dual PI3K/mTOR inhibitor that has exhibited promising activity against non-small cell lung cancer (NSCLC) in preclinical models." | 1.37 | Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy. ( Fang, G; Khuri, FR; Owonikoko, TK; Ramalingam, SS; Sun, SY; Tao, H; Xu, CX; Yue, P; Zhao, L, 2011) |
| "Perifosine is an alkylphospholipid exhibiting antitumor activity as shown in both preclinical studies and clinical trials." | 1.35 | Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. ( Fu, L; Khuri, FR; Kim, YA; Lonial, S; Sun, SY; Wang, X; Wu, X; Yue, P, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (15.48) | 18.7374 |
| 1990's | 2 (2.38) | 18.2507 |
| 2000's | 6 (7.14) | 29.6817 |
| 2010's | 47 (55.95) | 24.3611 |
| 2020's | 16 (19.05) | 2.80 |
| Authors | Studies |
|---|---|
| Gochfeld, DJ | 1 |
| Hamann, MT | 1 |
| Ren, Y | 2 |
| Cao, L | 2 |
| Wang, L | 3 |
| Zheng, S | 1 |
| Zhang, Q | 3 |
| Guo, X | 1 |
| Li, X | 11 |
| Chen, M | 2 |
| Wu, X | 3 |
| Furlong, F | 1 |
| Meng, Z | 1 |
| Xu, K | 1 |
| Zhao, H | 3 |
| Lu, L | 1 |
| Peng, Z | 1 |
| Chen, LL | 1 |
| Meng, X | 1 |
| Zhang, C | 2 |
| Ip, JD | 1 |
| Chan, WM | 1 |
| Chu, AW | 1 |
| Chan, KH | 1 |
| Jin, DY | 1 |
| Chen, H | 3 |
| Yuen, KY | 1 |
| To, KK | 1 |
| Saini, H | 3 |
| Choudhary, M | 3 |
| Sharma, H | 3 |
| Chowdhury, S | 3 |
| Mukherjee, S | 4 |
| Chowdhury, R | 3 |
| Marianna, B | 1 |
| Radka, M | 1 |
| Martin, K | 1 |
| Janka, V | 1 |
| Jan, M | 1 |
| Patrakova, E | 1 |
| Biryukov, M | 1 |
| Troitskaya, O | 1 |
| Gugin, P | 1 |
| Milakhina, E | 1 |
| Semenov, D | 1 |
| Poletaeva, J | 1 |
| Ryabchikova, E | 1 |
| Novak, D | 1 |
| Kryachkova, N | 1 |
| Polyakova, A | 1 |
| Zhilnikova, M | 1 |
| Zakrevsky, D | 1 |
| Schweigert, I | 1 |
| Koval, O | 1 |
| Ali Beg, MM | 1 |
| Saxena, A | 1 |
| Singh, VK | 1 |
| Akhter, J | 1 |
| Habib, H | 1 |
| Raisuddin, S | 1 |
| Xiong, R | 1 |
| Shao, D | 1 |
| Do, S | 1 |
| Chan, WK | 1 |
| Nenkov, M | 1 |
| Ma, Y | 4 |
| Haase, D | 1 |
| Zhou, Z | 1 |
| Li, Y | 9 |
| Petersen, I | 1 |
| Lu, G | 1 |
| Chen, Y | 6 |
| Pan, ST | 1 |
| Zhou, J | 1 |
| Yang, F | 1 |
| Zhou, SF | 1 |
| Ren, T | 3 |
| Maghsoudnia, N | 1 |
| Eftekhari, RB | 1 |
| Sohi, AN | 1 |
| Dorkoosh, FA | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
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| Alexander Ross, JB | 1 |
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| Hahn, S | 3 |
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| Ling, J | 2 |
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| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
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| Saud, N | 1 |
| Hoplock, LB | 1 |
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| Siddique, AB | 1 |
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| Mushtaq, Z | 1 |
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| Rasool, G | 1 |
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| Hua, W | 1 |
| Liu, ZM | 2 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 4 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 3 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
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| Lemin, AS | 1 |
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| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
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| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 2 |
| Dong, X | 2 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 2 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 2 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 2 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, L | 3 |
| Shan, A | 1 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Wang, J | 7 |
| Zhang, E | 1 |
| Zhang, J | 4 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 3 |
| Yan, Z | 2 |
| Wang, Y | 8 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
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| Du, L | 1 |
| Liu, X | 2 |
| Li, J | 9 |
| Li, P | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 3 |
| Wang, YS | 1 |
| Wang, C | 3 |
| Zhou, X | 2 |
| Wang, W | 2 |
| Wang, S | 3 |
| Hou, J | 1 |
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| Zhu, J | 2 |
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| Zhuang, T | 1 |
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| Heckl, D | 1 |
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| Mi, Y | 1 |
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| Wang, Z | 5 |
| Gurzu, S | 1 |
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| Sugimura, H | 2 |
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| Astutik, E | 1 |
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| Yu, N | 1 |
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| Govindasamy, V | 1 |
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| Annapurna, K | 1 |
| Dhakate, SR | 1 |
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3 reviews available for chloroquine and Lung Neoplasms
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Inhibition of autophagy enhances heat-induced apoptosis in human non-small cell lung cancer cells through ER stress pathways.
Topics: A549 Cells; Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Carcinoma, Non-Small-Cell Lung; Cell L | 2016 |
[Sarcoidosis therapy and its problems today].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents; Antineoplasti | 1978 |
2 trials available for chloroquine and Lung Neoplasms
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Diagnostic efficacy of a radioiodinated chloroquine analog in patients with malignant melanoma.
Topics: Brain Neoplasms; Chloroquine; Clinical Trials as Topic; Eye Neoplasms; Humans; Iodine Radioisotopes; | 1970 |
80 other studies available for chloroquine and Lung Neoplasms
| Article | Year |
|---|---|
Isolation and biological evaluation of filiformin, plakortide F, and plakortone G from the Caribbean sponge Plakortis sp.
Topics: Animals; Antimalarials; Bromobenzenes; Chromatography, High Pressure Liquid; Colonic Neoplasms; Diox | 2001 |
Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling.
Topics: Adenine; Autophagy; Autophagy-Related Protein 5; Cancer-Associated Fibroblasts; Carcinoma, Non-Small | 2021 |
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chlorocebus aethiops; Chloroquine; COVID- | 2022 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Design, Synthesis and Antiproliferative Evaluation of Bis-Indole Derivatives with a Phenyl Linker: Focus on Autophagy.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Huma | 2022 |
Chloroquine Enhances Death in Lung Adenocarcinoma A549 Cells Exposed to Cold Atmospheric Plasma Jet.
Topics: A549 Cells; Adenocarcinoma of Lung; Apoptosis; Chloroquine; Humans; Lung Neoplasms; Plasma Gases | 2023 |
Modulatory role of BV6 and chloroquine on the regulation of apoptosis and autophagy in non-small cell lung cancer cells.
Topics: Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Caspase 3; Caspase 9; Caspases; Cell Line, Tum | 2023 |
Activation of Chaperone-Mediated Autophagy Inhibits the Aryl Hydrocarbon Receptor Function by Degrading This Receptor in Human Lung Epithelial Carcinoma A549 Cells.
Topics: A549 Cells; Autophagy; Carcinoma; Chaperone-Mediated Autophagy; Chloroquine; Humans; Ligands; Lung; | 2023 |
Growth inhibitory role of the p53 activator SCH 529074 in non‑small cell lung cancer cells expressing mutant p53.
Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chl | 2020 |
Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells.
Topics: A549 Cells; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Proliferation | 2020 |
Chloroquine Assisted Delivery of microRNA Mimic Let-7b to NSCLC Cell Line by PAMAM (G5) - HA Nano-Carrier.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chloroquine; Dendrimers; Humans; Hyaluronic Acid; | 2021 |
Autophagy inhibition enhances the inhibitory effects of ursolic acid on lung cancer cells.
Topics: A549 Cells; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carcinoma, Non-Small-Cell Lu | 2020 |
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
Topics: Angiolipoma; Animals; Autophagy; Cell Proliferation; Chloroquine; Diacylglycerol Kinase; Down-Regula | 2021 |
Chinese herbal medicine Feiyanning cooperates with cisplatin to enhance cytotoxicity to non-small-cell lung cancer by inhibiting protective autophagy.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Prolif | 2021 |
Sensitizing TRAIL‑resistant A549 lung cancer cells and enhancing TRAIL‑induced apoptosis with the antidepressant amitriptyline.
Topics: A549 Cells; Amitriptyline; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroqui | 2021 |
PFKFB3 Inhibition Impairs Erlotinib-Induced Autophagy in NSCLCs.
Topics: Adenylate Kinase; Autophagosomes; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, | 2021 |
Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non-Small Cell Lung Cancer.
Topics: Animals; Antineoplastic Agents, Immunological; Autophagy; Carcinoma, Non-Small-Cell Lung; CD47 Antig | 2017 |
A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor.
Topics: Apoptosis; Arginase; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chloroquine; Chrom | 2017 |
High Serum HDGF Levels Are Predictive of Bone Metastasis and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
Topics: A549 Cells; Aged; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Chloroquine; Cohort Studies; Femal | 2017 |
Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Chloroquine | 2017 |
[Inhibition of autophagy initiation stage enhances camptothecin-induced apoptosis in NCI-H1975 cells].
Topics: Adenine; Apoptosis; Autophagy; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell | 2017 |
Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells.
Topics: A549 Cells; Adenocarcinoma of Lung; Caffeic Acids; Cantharidin; Cell Line, Tumor; Cell Proliferation | 2018 |
Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis.
Topics: A549 Cells; Autophagy; Cell Proliferation; Cell Survival; Chloroquine; Dose-Response Relationship, D | 2018 |
Chloroquine in combination with aptamer-modified nanocomplexes for tumor vessel normalization and efficient erlotinib/Survivin shRNA co-delivery to overcome drug resistance in EGFR-mutated non-small cell lung cancer.
Topics: Animals; Aptamers, Nucleotide; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chloroquine; Drug R | 2018 |
Metastatic cells are preferentially vulnerable to lysosomal inhibition.
Topics: Animals; Cell Line, Tumor; Chloroquine; Drug Resistance, Neoplasm; Gene Expression Regulation, Neopl | 2018 |
AZD9291 promotes autophagy and inhibits PI3K/Akt pathway in NSCLC cancer cells.
Topics: A549 Cells; Acrylamides; Aniline Compounds; Animals; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell | 2019 |
Lysosome Membrane Permeabilization and Disruption of the Molecular Target of Rapamycin (mTOR)-Lysosome Interaction Are Associated with the Inhibition of Lung Cancer Cell Proliferation by a Chloroquinoline Analog.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Chloroquinolinols; Humans; | 2019 |
Anti-cancer effects of CQBTO, a chloroquine, and benzo(e)triazine oxide conjugate.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal | 2019 |
Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer.
Topics: Acrylamides; Aldehyde Dehydrogenase 1 Family; Aniline Compounds; Animals; Antineoplastic Agents; Aut | 2019 |
The triazole linked galactose substituted dicyano compound can induce autophagy in NSCLC cell lines.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Protein | 2019 |
Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; A | 2013 |
The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib.
Topics: Animals; Antimalarials; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Blotti | 2013 |
Reversal of lung cancer multidrug resistance by pH-responsive micelleplexes mediating co-delivery of siRNA and paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Chloroquine; Drug Carriers; Drug Res | 2014 |
Autophagy sensitivity of neuroendocrine lung tumor cells.
Topics: Adaptor Proteins, Signal Transducing; Antimalarials; Autophagy; Cell Line, Tumor; Cell Proliferation | 2013 |
Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer.
Topics: Anaplastic Lymphoma Kinase; Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Chloroquine | 2014 |
Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro.
Topics: Aminoglycosides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apo | 2014 |
The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.
Topics: Antineoplastic Agents; Antirheumatic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Caspases; Ce | 2014 |
Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Blotting, Western; Ca | 2014 |
Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells.
Topics: Animals; Autophagy; Cell Line, Tumor; Chick Embryo; Chloroquine; Drug Resistance, Neoplasm; Gene Kno | 2014 |
Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent.
Topics: Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; HEK293 Cells; Humans; Lung Neoplasms; | 2014 |
PROX1 promotes metabolic adaptation and fuels outgrowth of Wnt(high) metastatic colon cancer cells.
Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Chloroquine; Colo | 2014 |
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Benzylisoquinolines; | 2015 |
Chloroquine enhances gefitinib cytotoxicity in gefitinib-resistant nonsmall cell lung cancer cells.
Topics: Adenine; Antineoplastic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chloroq | 2015 |
Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung | 2015 |
Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death.
Topics: Antineoplastic Agents; Autophagy; Cell Line, Tumor; Chloroquine; Dose-Response Relationship, Drug; G | 2015 |
Cytotoxicity of Ru(II) piano-stool complexes with chloroquine and chelating ligands against breast and lung tumor cells: Interactions with DNA and BSA.
Topics: Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cattle; Cell Line, Tumor; Chelating | 2015 |
AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cel | 2015 |
Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death.
Topics: Antimalarials; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Prolifer | 2016 |
The M2 macrophages induce autophagic vascular disorder and promote mouse sensitivity to urethane-related lung carcinogenesis.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Apoptosis; Autophagy; Benzofurans; Capillary Permea | 2016 |
ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells.
Topics: A549 Cells; Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Proliferation; Chloroquine; C | 2016 |
The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to γ-rays and/or erlotinib.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle; Cel | 2016 |
Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress.
Topics: Antineoplastic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferati | 2016 |
Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells.
Topics: Acetylcysteine; Apoptosis; Autophagy; Blotting, Western; Caspase 3; Caspase 7; Cell Line, Tumor; Cel | 2016 |
Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells.
Topics: A549 Cells; Acetylcysteine; Apoptosis; Autophagy; Blotting, Western; Cell Line; Chloroquine; Glutath | 2016 |
Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model.
Topics: Animals; Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Cyclooxygenase 2; Female; Gene Exp | 2016 |
Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis.
Topics: Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Movement; Cell Survival; Chemokine | 2016 |
Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line | 2016 |
Autophagy inhibition upregulates CD4
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antirheumatic Agents; Apoptosis; Autophagy; C | 2016 |
Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patients.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; CD8-Positive T-Lymphocytes; Cell Proliferati | 2008 |
[Modulation of TLR9 on anti-tumor immune responses of peripheral blood mononuclear cells from patients with non-small-cell lung cancer].
Topics: Aged; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Carcinoma, Non-Small-Cell Lung; CD3 Com | 2008 |
Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.
Topics: Animals; Autophagy; Cell Cycle Proteins; Cell Line, Tumor; Chloroquine; F-Box Proteins; F-Box-WD Rep | 2009 |
Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: potential implications for the treatment of a therapeutic-resistant malignancy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Chloroquine; Gene Expression Regulation, Neopl | 2011 |
Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy.
Topics: Animals; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; | 2011 |
Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Bcl-2-Like Protein | 2011 |
Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Cathepsin B; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Re | 2013 |
STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. 3. EFFECTS OF CHLOROQUINE ON HUMAN CANCERS.
Topics: Chloroquine; Drug Therapy; Fibroblasts; Geriatrics; Lung Neoplasms; Neoplasms; Radiography; Radiogra | 1964 |
[COLLIQUATIVE AMEBIC HAPITITIS, WITH SECONDARY PULMONARY ABSCESS. ASSOCIATED CHLOROQUINE-EMETINE TREATMENT. RECOVERY].
Topics: Abscess; Chloroquine; Emetine; Geriatrics; Liver Abscess; Liver Abscess, Amebic; Lung Abscess; Lung | 1963 |
Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells.
Topics: Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Shape; Chloroquine; Humans; Lung Neoplasms | 2006 |
Neutral proteinase inhibitors and antimetastatic effects in mice.
Topics: Animals; Aurintricarboxylic Acid; Chloroquine; Indomethacin; Lung Neoplasms; Mice; Mice, Inbred C57B | 1980 |
Targeting the cytotoxicity of topoisomerase II-directed epipodophyllotoxins to tumor cells in acidic environments.
Topics: Amsacrine; Animals; Carcinoma, Small Cell; Chloroquine; DNA Damage; DNA Topoisomerases, Type II; DNA | 1994 |
Chloroquine: nonselective inhibition of recovery from radiation injury in tumors and normal tissues.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Chloroquine; DNA; DNA Damage; DNA Repair; DNA, Neoplas | 1974 |
Functional defects of NK cells treated with chloroquine mimic the lytic defects observed in perforin-deficient mice.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Movement; Cells, Cultured; Chloroquine | 2000 |
Tumor- and drug-induced cutaneous neuro-phospholipidosis.
Topics: Adult; Aged; Analgesics; Axons; Carcinoma, Bronchogenic; Chloroquine; Ergotamine; Female; Humans; Li | 1975 |
Characterization of ligand binding and processing by gastrin-releasing peptide receptors in a small-cell lung cancer cell line.
Topics: Anti-Bacterial Agents; Binding, Competitive; Bombesin; Carcinoma, Small Cell; Cell Line; Chloroquine | 1992 |
Regulation of hormone production in small cell carcinoma of the lung.
Topics: Adrenocorticotropic Hormone; Bethanechol; Bethanechol Compounds; Calcitonin; Carcinoma, Small Cell; | 1985 |
Mediation of reduction of spontaneous and experimental pulmonary metastases by ricin A-chain immunotoxin 45-2D9-RTA with potentiation by systemic monensin in mice.
Topics: Ammonium Chloride; Animals; Antigens, Neoplasm; Chloroquine; Dimethyl Sulfoxide; Drug Synergism; Fem | 1988 |
Antiteratogenic and anticarcinogenic effects of X-rays in urethane-treated NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Chloroquine; Female; Lung Neoplasms; Male; Mice | 1987 |
[Current usage of antineoplastic agents].
Topics: Antineoplastic Agents; Bronchial Neoplasms; Chloroquine; Chymotrypsin; Cyclophosphamide; Female; Fib | 1971 |
[Loefgren's syndrome in a 37-year-old woman].
Topics: Adrenal Cortex Hormones; Adult; Chloroquine; Drug Therapy, Combination; Erythema Nodosum; Female; Hu | 1973 |
[Treatment of lung cancer (especially small-sized) with Bleomycin--significance of CPBP therapy].
Topics: Adenocarcinoma; Adult; Aged; Animals; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Chloroq | 1970 |