chloroquine has been researched along with Lipidoses in 34 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic treatment of rats with the amphipilic drugs chloroquine and chlorphentermine caused prominent anterior polar cataracts in virtually all rats." | 7.66 | Anterior polar cataract and lysosomal alterations in the lens of rats treated with the amphiphilic lipidosis-inducing drugs chloroquine and chlorphentermine. ( Drenckhahn, D, 1978) |
| "Chronic treatment of rats with the amphipilic drugs chloroquine and chlorphentermine caused prominent anterior polar cataracts in virtually all rats." | 3.66 | Anterior polar cataract and lysosomal alterations in the lens of rats treated with the amphiphilic lipidosis-inducing drugs chloroquine and chlorphentermine. ( Drenckhahn, D, 1978) |
| " Chloroquine, ergotamine, ethaverine and chronic abuse of non-narcotic analgesic drugs seem to be responsible for the drug-induced cutaneous neuro-phospholipidosis, whereas the same condition was found in two patients with metastatic bronchogenic carcinoma and malignant melanoma." | 3.65 | Tumor- and drug-induced cutaneous neuro-phospholipidosis. ( Orfanos, CE; Runne, U, 1975) |
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| "CQ induced a phospholipidosis-like phenotype, characterized by the appearance of numerous multivesicular and multilamellar bodies (MLBs/MVBs) within the lumen of expanded cytoplasmic vesicles." | 1.37 | Effect of phospholipidosis on the cellular pharmacokinetics of chloroquine. ( Rosania, GR; Zhang, X; Zheng, N, 2011) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| "Chloroquine caused severe lipidosis in the neuroretina and slight photoreceptor cell degeneration after 12 weeks of treatment." | 1.30 | [Chloroquine- and chlorphentermin-induced lipidosis in rat retina]. ( Bredehorn, T; Duncker, GI, 1999) |
| "Corneal opacity, reversible retinal lipidosis and irreversible receptor cell degeneration are known to occur after long-term treatment with chloroquine." | 1.29 | Chloroquine-induced lipidosis in the rat retina: a functional and morphological study. ( Bredehorn, T; Duncker, G; Schmiederer, M, 1995) |
| "It is known to cause lipidosis and photoreceptor degeneration in the human and the rat retina." | 1.29 | Chloroquine-induced lipidosis in the rat retina: functional and morphological changes after withdrawal of the drug. ( Bredehorn, T; Duncker, G, 1996) |
| "To induce lipidosis, rats were pretreated for several weeks with chloroquine or chlorphentermine; they then received combined treatment with the lipidosis-inducing drug plus acarbose." | 1.27 | Fusion of storage lysosomes in experimental lipidosis and glycogenosis. ( Lüllmann-Rauch, R; Watermann, D, 1987) |
| "Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers." | 1.26 | Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals. ( Lüllmann-Rauch, R; Stoermer, B, 1982) |
| "The influence of three potent lipidosis-inducing agents, i." | 1.26 | Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs. ( Duncker, G; Hartmann, F; Mohr, K, 1982) |
| "A drug-induced lipidosis of the central nervous system of chickens is reported." | 1.25 | A drug-induced cerebrospinal lipodystrophy in the domestic chicken (Gallus domesticus). ( Bay, WW; Dukes, TW; Gleiser, CA; Read, WK, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (64.71) | 18.7374 |
| 1990's | 5 (14.71) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Yamagiwa, Y | 1 |
| Takei, Y | 1 |
| Koizumi, H | 1 |
| Nemoto, S | 1 |
| Kurata, M | 1 |
| Satoh, H | 1 |
| Zheng, N | 1 |
| Zhang, X | 1 |
| Rosania, GR | 1 |
| KURACHI, Y | 1 |
| YONEMURA, D | 1 |
| Linthorst, GE | 1 |
| Hollak, CE | 1 |
| Albay, D | 1 |
| Adler, SG | 1 |
| Philipose, J | 1 |
| Calescibetta, CC | 1 |
| Romansky, SG | 1 |
| Cohen, AH | 1 |
| Ahmed, MH | 1 |
| Lüllmann-Rauch, R | 9 |
| Stoermer, B | 1 |
| Matsuzawa, Y | 1 |
| Hostetler, KY | 1 |
| Drenckhahn, D | 4 |
| Jacobi, B | 1 |
| D'Amico, DJ | 1 |
| Kenyon, KR | 1 |
| Duncker, G | 3 |
| Hartmann, F | 1 |
| Mohr, K | 1 |
| Frisch, W | 1 |
| Bichler, E | 1 |
| Spoendlin, H | 1 |
| Schmiederer, M | 1 |
| Bredehorn, T | 3 |
| Pods, R | 1 |
| von Witzendorff, B | 1 |
| Duncker, GI | 1 |
| Goldberg MVermelin, L | 1 |
| Mostermans, P | 1 |
| Lécolle, S | 1 |
| Septier, D | 1 |
| Godeau, G | 1 |
| LeGeros, RZ | 1 |
| Seiler, KU | 1 |
| Thiel, HJ | 2 |
| Wassermann, O | 2 |
| Orfanos, CE | 1 |
| Runne, U | 1 |
| Pülhorn, G | 1 |
| Philippart, M | 1 |
| Kamensky, E | 1 |
| Joshi, UM | 1 |
| Kodavanti, PR | 1 |
| Coudert, B | 1 |
| Dwyer, TM | 1 |
| Mehendale, HM | 1 |
| Watermann, D | 1 |
| Dietzmann, K | 1 |
| Kemnitz, P | 1 |
| Schneidewind, J | 1 |
| Lüllmann, H | 1 |
| Dukes, TW | 1 |
| Read, WK | 1 |
| Bay, WW | 1 |
| Gleiser, CA | 1 |
| Podos, SM | 1 |
3 reviews available for chloroquine and Lipidoses
| Article | Year |
|---|---|
Nitric oxide might be involved in the pathogenesis of chloroquine-induced lipidosis.
Topics: Animals; Antimalarials; Chloroquine; Glomerulonephritis; Humans; Lipidoses; Nitric Oxide; Nitric Oxi | 2005 |
Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review.
Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Per | 1981 |
[Drug-induced phospholipid storage disease].
Topics: Adrenal Gland Diseases; Amitriptyline; Animals; Anticholesteremic Agents; Appetite Depressants; Body | 1973 |
31 other studies available for chloroquine and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone.
Topics: Administration, Ophthalmic; Aging; Amiodarone; Animals; Chloroquine; Cornea; Disease Models, Animal; | 2019 |
Effect of phospholipidosis on the cellular pharmacokinetics of chloroquine.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Cell Size; Chloroquine; Dogs; Lipidoses; Ph | 2011 |
[ERG, WITH SPECIAL REFERENCE TO ITS CORRELATION WITH INTERNAL DISEASES].
Topics: Anesthesia; Anesthesiology; Behcet Syndrome; Blood Circulation; Chloroquine; Diabetic Retinopathy; E | 1964 |
Chloroquine-induced phospholipidosis of the kidney mimicking Fabry's disease.
Topics: alpha-Galactosidase; Antirheumatic Agents; Chloroquine; Diagnosis, Differential; Fabry Disease; Fema | 2003 |
Chloroquine-induced lipidosis mimicking Fabry disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Diagnosis, Differential; Fabry Disease; Fe | 2005 |
Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.
Topics: Adrenal Glands; Animals; Chloroquine; Chlorphentermine; Female; Guinea Pigs; Hypothalamus; Kidney; L | 1982 |
Effects of chloroquine and 4,4'-bis(diethylaminoethoxy)alpha, beta-diethyldiphenylethane on the incorporation of [3H]glycerol into the phospholipids of rat liver lysosomes and other subcellular fractions, in vivo.
Topics: Animals; Chloroquine; Glycerol; Hexestrol; Lipidoses; Liver; Lysosomes; Male; Microsomes, Liver; Mit | 1980 |
Corneal lipidosis in rats treated with amphiphilic cationic drugs.
Topics: Animals; Cations; Chloroquine; Chlorphentermine; Corneal Diseases; Female; Iprindole; Lipidoses; Mal | 1983 |
Drug-induced lipidoses of the cornea and conjunctiva.
Topics: Amiodarone; Amodiaquine; Chloroquine; Conjunctival Diseases; Corneal Diseases; Fabry Disease; Female | 1981 |
Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs.
Topics: Adrenal Cortex; Animals; Chloroquine; Corticosterone; Indoles; Iprindole; Lipidoses; Male; Rats; Rat | 1982 |
Effects of several lipidosis-including drugs upon the area postrema and adjacent medullary nuclei of adult rats. I. Alterations is perikarya and dendrites.
Topics: Animals; Blood-Brain Barrier; Brain Diseases; Chloroquine; Chlorphentermine; Female; Lipidoses; Male | 1980 |
Experimental lipidosis of the inner ear.
Topics: Animals; Auditory Pathways; Chloroquine; Chlorphentermine; Guinea Pigs; Hair Cells, Auditory, Inner; | 1980 |
Chloroquine-induced lipidosis in the rat retina: a functional and morphological study.
Topics: Animals; Chloroquine; Electroretinography; Female; Lipidoses; Rats; Rats, Wistar; Retina; Retinal De | 1995 |
The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; beta-N-Acetylhexosaminidases; Cattle; Cells, Cultu | 1996 |
Chloroquine-induced lipidosis in the rat retina: functional and morphological changes after withdrawal of the drug.
Topics: Animals; Antimalarials; Chloroquine; Electroretinography; Female; Lipidoses; Photoreceptor Cells; Ra | 1996 |
[Chloroquine- and chlorphentermin-induced lipidosis in rat retina].
Topics: Administration, Oral; Animals; Chloroquine; Chlorphentermine; Dose-Response Relationship, Drug; Elec | 1999 |
Fragmentation of the distal portion of Tomes' processes of secretory ameloblasts in the forming enamel of rat incisors.
Topics: Ameloblasts; Animals; Chloroquine; Dental Enamel; Fatty Acids; Incisor; Lipidoses; Male; Rats; Rats, | 1998 |
[Chloroquine keratopathy as an example of drug-induced phospholipidosis (contribution to the pathogenesis of cornea verticillata) (author's transl)].
Topics: Adrenal Glands; Animals; Chloroquine; Chlorphentermine; Corneal Diseases; Cytoplasm; Hydrogen-Ion Co | 1977 |
Drug-induced retinal lipidosis: differential susceptibilities of pigment epithelium and neuroretina toward several amphiphilic cationic drugs.
Topics: Animals; Chloroquine; Female; Hexestrol; Inclusion Bodies; Lipidoses; Male; Microscopy, Electron; Pi | 1978 |
Tumor- and drug-induced cutaneous neuro-phospholipidosis.
Topics: Adult; Aged; Analgesics; Axons; Carcinoma, Bronchogenic; Chloroquine; Ergotamine; Female; Humans; Li | 1975 |
[Ultrastructural aspects of chloroquin-keratopathy (author's transl)].
Topics: Chloroquine; Cornea; Corneal Diseases; Epithelium; Humans; Inclusion Bodies; Lipidoses; Microscopy, | 1976 |
Anterior polar cataract and lysosomal alterations in the lens of rats treated with the amphiphilic lipidosis-inducing drugs chloroquine and chlorphentermine.
Topics: Acid Phosphatase; Animals; Cataract; Chloroquine; Chlorphentermine; Epithelium; Female; Inclusion Bo | 1978 |
Lens opacities associated with lipidosis-like ultrastructural alterations in rats treated with chloroquine, chlorphentermine, or iprindole.
Topics: Animals; Cataract; Chloroquine; Chlorphentermine; Cytoplasm; Epithelial Cells; Epithelium; Female; I | 1977 |
Chemical induction of lysosomal storage.
Topics: Acetates; Aza Compounds; Cell Membrane; Chloroquine; Fibroblasts; Fluorenes; Hexosaminidases; Humans | 1976 |
Types of interaction of amphiphilic drugs with phospholipid vesicles.
Topics: Amiodarone; Anilino Naphthalenesulfonates; Binding Sites; Chloramphenicol; Chloroquine; Chlorpromazi | 1988 |
Fusion of storage lysosomes in experimental lipidosis and glycogenosis.
Topics: Acarbose; Animals; Autophagy; Chloroquine; Chlorphentermine; Endocytosis; Female; Glycogen Storage D | 1987 |
[Morphologic and histochemical studies of the development of chloroquine-induced storage disease in the semilunar ganglion of the rat].
Topics: Animals; Chloroquine; Diagnosis, Differential; Histocytochemistry; Lipidoses; Lysosomes; Male; Neuro | 1985 |
A drug-induced cerebrospinal lipodystrophy in the domestic chicken (Gallus domesticus).
Topics: Animals; Brain; Cat Diseases; Cats; Central Nervous System Diseases; Chickens; Chinchilla; Chloroqui | 1971 |
Retinal pigmentary disease.
Topics: Adolescent; Adult; Blindness; Brain Diseases; Chloroquine; Chorioretinitis; Choroid; Diagnosis, Diff | 1967 |