chloroquine has been researched along with Leukemia in 13 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Verapamil pretreatment of cytoplasts from resistant cells revealed the subcellular DNP-sensitive uptake present in parental cytoplasts." | 5.28 | Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts. ( Daniel, JC; Lecerf, JM; Levy, SB; Slapak, CA, 1992) |
| "Verapamil pretreatment of cytoplasts from resistant cells revealed the subcellular DNP-sensitive uptake present in parental cytoplasts." | 1.28 | Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts. ( Daniel, JC; Lecerf, JM; Levy, SB; Slapak, CA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (61.54) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Palmeira dos Santos, C | 1 |
| Pereira, GJ | 1 |
| Barbosa, CM | 1 |
| Jurkiewicz, A | 1 |
| Smaili, SS | 1 |
| Bincoletto, C | 1 |
| Guo, S | 1 |
| Liang, Y | 1 |
| Murphy, SF | 1 |
| Huang, A | 1 |
| Shen, H | 1 |
| Kelly, DF | 1 |
| Sobrado, P | 1 |
| Sheng, Z | 1 |
| Lu, Y | 1 |
| Liu, XF | 1 |
| Liu, TR | 1 |
| Fan, RF | 1 |
| Xu, YC | 1 |
| Zhang, XZ | 1 |
| Liu, LL | 1 |
| HIRAKI, K | 1 |
| KIMURA, I | 1 |
| Sasaki, R | 1 |
| Slapak, CA | 1 |
| Lecerf, JM | 1 |
| Daniel, JC | 1 |
| Levy, SB | 1 |
| Beck, WT | 4 |
| Cirtain, MC | 2 |
| Danks, MK | 1 |
| Felsted, RL | 2 |
| Safa, AR | 2 |
| Wolverton, JS | 1 |
| Suttle, DP | 1 |
| Trent, JM | 1 |
| Glover, CJ | 1 |
| Zamora, JM | 2 |
| Pearce, HL | 1 |
| Calabro, JJ | 1 |
| Katz, RM | 1 |
| Maltz, BA | 1 |
| Tanneberger, S | 1 |
| Bacigalupo, G | 1 |
| Ota, K | 1 |
3 reviews available for chloroquine and Leukemia
| Article | Year |
|---|---|
[Various factors determining direction of differentiation in leukemic cells].
Topics: Acetamides; Animals; Antineoplastic Agents; Basophils; Carcinogens; Cell Differentiation; Chloroquin | 1996 |
A critical reappraisal of juvenile rheumatoid arthritis.
Topics: Agammaglobulinemia; Arthritis, Juvenile; Aspirin; Cardiomegaly; Child; Child, Preschool; Chloroquine | 1971 |
Multiple combination therapy in cancer chemotherapy in Japan.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chloroquine; Cyclophosphamide; Cytarabine; Drug | 1969 |
10 other studies available for chloroquine and Leukemia
| Article | Year |
|---|---|
Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine‑induced death of leukaemia cells.
Topics: Adenine; Antimalarials; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoc | 2014 |
A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications.
Topics: Animals; Autophagy; Cell Survival; Chloroquine; Dactinomycin; Endosomes; Fluorescent Dyes; Gene Expr | 2015 |
Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Celecoxib; Cell Proliferation; Chloroquine; HL-60 Cells | 2016 |
STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. IV. EFFECTS OF CHLOROQUINE ON MALIGNANT LYMPHOMAS.
Topics: Chloroquine; Fibroblasts; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lympho | 1964 |
Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Compartmentation; Chloroquine; | 1992 |
Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Chromosome Banding; Chromosome | 1987 |
Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine.
Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Su | 1988 |
Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry, Physic | 1988 |
Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukemic cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Count; Cells, Cultured; Chloroquine; Drug R | 1986 |
[On the value of chloroquine in the treatment of malignant tumor diseases].
Topics: Adenocarcinoma, Scirrhous; Adult; Aged; Animals; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, E | 1967 |