chloroquine has been researched along with Leukemia L 1210 in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-seven new acridone alkaloid derivatives (SA compounds) were tested for antimalarial activity in vitro." | 3.68 | Activities of new acridone alkaloid derivatives against Plasmodium yoelii in vitro. ( Fujimura, K; Fujioka, H; Fujita, M; Kato, N; Nishiyama, Y, 1990) |
| "Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating subpopulation." | 1.38 | Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression. ( Chin, BB; Dai, D; Greer, KL; Hjelemand, A; Lascola, C; McDougald, D; McLendon, R; Metzler, SD; Reiman, R; Rich, J; Song, H; Storms, R; Vaidyanathan, G, 2012) |
| "Chloroquine is a lysosomotropic agent that has been reported to enhance in vitro cytotoxicity of basic anticancer drugs." | 1.36 | Triggering liposomal drug release with a lysosomotropic agent. ( Lee, RJ; Li, H; Wu, J; Xiong, S; Yu, B, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiong, S | 1 |
| Li, H | 1 |
| Yu, B | 1 |
| Wu, J | 1 |
| Lee, RJ | 1 |
| Chin, BB | 1 |
| Hjelemand, A | 1 |
| Rich, J | 1 |
| Song, H | 1 |
| Lascola, C | 1 |
| Storms, R | 1 |
| McLendon, R | 1 |
| Reiman, R | 1 |
| Greer, KL | 1 |
| Metzler, SD | 1 |
| McDougald, D | 1 |
| Dai, D | 1 |
| Vaidyanathan, G | 1 |
| Jensen, PB | 1 |
| Sørensen, BS | 1 |
| Sehested, M | 1 |
| Grue, P | 1 |
| Demant, EJ | 1 |
| Hansen, HH | 1 |
| Prescott, B | 1 |
| Fujioka, H | 1 |
| Kato, N | 1 |
| Fujita, M | 1 |
| Fujimura, K | 1 |
| Nishiyama, Y | 1 |
| Junqua, S | 1 |
| Wiels, J | 1 |
| Tursz, T | 1 |
| Le Pecq, JB | 1 |
6 other studies available for chloroquine and Leukemia L 1210
| Article | Year |
|---|---|
Triggering liposomal drug release with a lysosomotropic agent.
Topics: Animals; Antibiotics, Antineoplastic; Arylsulfonates; Cell Line, Tumor; Chloroquine; Daunorubicin; F | 2010 |
Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Chlo | 2012 |
Targeting the cytotoxicity of topoisomerase II-directed epipodophyllotoxins to tumor cells in acidic environments.
Topics: Amsacrine; Animals; Carcinoma, Small Cell; Chloroquine; DNA Damage; DNA Topoisomerases, Type II; DNA | 1994 |
Thiosemicarbazones and hydrazones of alpha-methylchalkone as potential chemotherapeutic agents.
Topics: Animals; Antimalarials; Antineoplastic Agents; Carcinoma 256, Walker; Chalcone; Chloroquine; Drug Ev | 1975 |
Activities of new acridone alkaloid derivatives against Plasmodium yoelii in vitro.
Topics: Acridines; Acridones; Alkaloids; Animals; Antimalarials; Cell Survival; Chloroquine; Erythrocytes; I | 1990 |
Antitumor activity against L1210 mouse leukemia of immunotoxins containing a monoclonal antibody to the glycolipid globotriaosylceramide.
Topics: Animals; Antibody Specificity; Cell Line; Chloroquine; Globosides; Glycolipids; Glycosphingolipids; | 1987 |