chloroquine has been researched along with Leukemia, Promyelocytic, Acute in 3 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML), as standing out for its distinguished sensitivity to all-trans retinoic acid and arsenic trioxide (ATO, As2O3)." | 7.88 | Chloroquine aggravates the arsenic trioxide (As2O3)-induced apoptosis of acute promyelocytic leukemia NB4 cells via inhibiting lysosomal degradation in vitro. ( Liu, DM; Yang, L; Zhang, XD, 2018) |
| "Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML), as standing out for its distinguished sensitivity to all-trans retinoic acid and arsenic trioxide (ATO, As2O3)." | 3.88 | Chloroquine aggravates the arsenic trioxide (As2O3)-induced apoptosis of acute promyelocytic leukemia NB4 cells via inhibiting lysosomal degradation in vitro. ( Liu, DM; Yang, L; Zhang, XD, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, DM | 1 |
| Zhang, XD | 1 |
| Yang, L | 1 |
| Orfali, N | 1 |
| O'Donovan, TR | 1 |
| Nyhan, MJ | 1 |
| Britschgi, A | 1 |
| Tschan, MP | 1 |
| Cahill, MR | 1 |
| Mongan, NP | 1 |
| Gudas, LJ | 1 |
| McKenna, SL | 1 |
| Shunkert, H | 1 |
| Handt, S | 1 |
| de Wit, M | 1 |
| Gladziwa, U | 1 |
| Glöckner, WM | 1 |
| Sieberth, HG | 1 |
3 other studies available for chloroquine and Leukemia, Promyelocytic, Acute
| Article | Year |
|---|---|
Chloroquine aggravates the arsenic trioxide (As2O3)-induced apoptosis of acute promyelocytic leukemia NB4 cells via inhibiting lysosomal degradation in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Tr | 2018 |
Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Antineoplastic Agents; Antirheumatic Agents; Autophag | 2015 |
[Transfusion malaria in promyelocytic leukemia].
Topics: Adult; Animals; Chloroquine; Drug Therapy, Combination; Erythrocyte Transfusion; Female; Humans; Leu | 1988 |