chloroquine has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 9 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| He, W | 1 |
| Zhao, CF | 1 |
| Chen, L | 1 |
| Hu, HX | 1 |
| Chiou, JT | 1 |
| Lee, YC | 1 |
| Chang, LS | 1 |
| Hseu, YC | 1 |
| Shen, YC | 1 |
| Kao, MC | 1 |
| Mathew, DC | 1 |
| Karuppaiya, P | 1 |
| Li, ML | 1 |
| Yang, HL | 1 |
| Kamitsuji, Y | 1 |
| Kuroda, J | 1 |
| Kimura, S | 1 |
| Toyokuni, S | 1 |
| Watanabe, K | 1 |
| Ashihara, E | 1 |
| Tanaka, H | 1 |
| Yui, Y | 1 |
| Watanabe, M | 1 |
| Matsubara, H | 1 |
| Mizushima, Y | 1 |
| Hiraumi, Y | 1 |
| Kawata, E | 1 |
| Yoshikawa, T | 1 |
| Maekawa, T | 1 |
| Nakahata, T | 1 |
| Adachi, S | 1 |
| Bellodi, C | 1 |
| Lidonnici, MR | 1 |
| Hamilton, A | 1 |
| Helgason, GV | 1 |
| Soliera, AR | 1 |
| Ronchetti, M | 1 |
| Galavotti, S | 1 |
| Young, KW | 1 |
| Selmi, T | 1 |
| Yacobi, R | 1 |
| Van Etten, RA | 1 |
| Donato, N | 1 |
| Hunter, A | 1 |
| Dinsdale, D | 1 |
| Tirrò, E | 1 |
| Vigneri, P | 1 |
| Nicotera, P | 1 |
| Dyer, MJ | 1 |
| Holyoake, T | 1 |
| Salomoni, P | 2 |
| Calabretta, B | 2 |
| Patel, H | 1 |
| Marley, SB | 1 |
| Gordon, MY | 1 |
| Carew, JS | 1 |
| Nawrocki, ST | 1 |
| Kahue, CN | 1 |
| Zhang, H | 1 |
| Yang, C | 1 |
| Chung, L | 1 |
| Houghton, JA | 1 |
| Huang, P | 1 |
| Giles, FJ | 1 |
| Cleveland, JL | 1 |
| Jiang, YZ | 1 |
| Mavroudis, D | 1 |
| Dermime, S | 1 |
| Hensel, N | 1 |
| Couriel, D | 1 |
| Molldrem, J | 1 |
| Barrett, AJ | 1 |
1 review available for chloroquine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Suppression of autophagy by BCR/ABL.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Benzamides; Chloroquine; Drug Sy | 2012 |
8 other studies available for chloroquine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
[Chloroquine Enhances BIIB021-induced Apoptosis in Chronic Myeloid Leukemia Cells Bearing T315I Mutation].
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Chloroquine; Fusion Proteins, b | 2022 |
Hydroquinone-selected chronic myelogenous leukemia cells are sensitive to chloroquine-induced cytotoxicity via MCL1 suppression and glycolysis inhibition.
Topics: Apoptosis; Chloroquine; Glycolysis; Humans; Hydroquinones; K562 Cells; Leukemia, Myelogenous, Chroni | 2023 |
Ganoderma tsugae induced ROS-independent apoptosis and cytoprotective autophagy in human chronic myeloid leukemia cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2019 |
The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias.
Topics: Animals; Apoptosomes; Autophagy; Caspases; Cell Line, Tumor; Chloroquine; Cytoprotection; Disease Mo | 2008 |
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Benzamides; Calcium; Cell Death; Cell Line, Tumor; Chloro | 2009 |
Detection in primary chronic myeloid leukaemia cells of p210BCR-ABL1 in complexes with adaptor proteins CBL, CRKL, and GRB2.
Topics: Adaptor Proteins, Signal Transducing; Caspases; Cell Line, Tumor; Chloroquine; Fusion Proteins, bcr- | 2006 |
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.
Topics: Antineoplastic Agents; Autophagy; Cathepsin D; Cell Line, Tumor; Chloroquine; Drug Resistance, Neopl | 2007 |
Alloreactive CD4+ T lymphocytes can exert cytotoxicity to chronic myeloid leukaemia cells processing and presenting exogenous antigen.
Topics: Bone Marrow Transplantation; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Cyclopentanes; Cy | 1996 |