chloroquine has been researched along with Leukemia, Erythroblastic, Acute in 9 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Leukemia, Erythroblastic, Acute: A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Transferrin degradation was not found, which leads us to suggest a process of 'acid flushing' for the dissociation of iron from transferrin without the involvement of endosome-lysosome fusion." | 1.27 | Iron metabolism of established human hematopoietic cell lines in vitro. ( Forsbeck, K; Nilsson, K, 1983) |
| "When the human erythroleukemia cell line K562 is treated with OKT9, a monoclonal antibody against the transferrin receptor, effects on receptor dynamics and degradation ensue." | 1.27 | Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor. ( Harford, JB; Klausner, RD; Rao, K; Weissman, AM, 1986) |
| "A different murine erythroleukemia cell line which does not differentiate in response to EP was found to have only the lower affinity binding sites for the hormone." | 1.27 | Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells. ( Goldwasser, E; Krantz, SB; Sawyer, ST, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kazemi, A | 1 |
| Sadri, M | 1 |
| Houshmand, M | 1 |
| Yazdi, N | 1 |
| Zarif, MN | 1 |
| Anjam-Najmedini, A | 1 |
| Tavakoli, R | 1 |
| Ojaghi, M | 1 |
| Ajami, M | 2 |
| Atashi, A | 1 |
| Iyamu, E | 1 |
| Perdew, H | 1 |
| Woods, G | 1 |
| Forsbeck, K | 1 |
| Nilsson, K | 1 |
| Breuer, W | 1 |
| Epsztejn, S | 1 |
| Cabantchik, ZI | 1 |
| Mizutani, Y | 1 |
| Bonavida, B | 1 |
| Nio, Y | 1 |
| Yoshida, O | 1 |
| Krajewski, WA | 1 |
| Wu-Pong, S | 1 |
| Weiss, TL | 1 |
| Hunt, CA | 1 |
| Weissman, AM | 1 |
| Klausner, RD | 1 |
| Rao, K | 1 |
| Harford, JB | 1 |
| Sawyer, ST | 1 |
| Krantz, SB | 1 |
| Goldwasser, E | 1 |
9 other studies available for chloroquine and Leukemia, Erythroblastic, Acute
| Article | Year |
|---|---|
The anticancer effects of pharmacological inhibition of autophagy in acute erythroid leukemia cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Autophagy; Cell Line, Tumor; Chloroquine; Cyclin-Dependent | 2018 |
Growth inhibitory and differentiation effects of chloroquine and its analogue on human leukemic cells potentiate fetal hemoglobin production by targeting the polyamine pathway.
Topics: Arginase; Cell Differentiation; Chloroquine; Drug Delivery Systems; Drug Synergism; Fetal Hemoglobin | 2009 |
Iron metabolism of established human hematopoietic cell lines in vitro.
Topics: Ammonium Chloride; Cell Line; Chloroquine; Endocytosis; Erythrocytes; Ferritins; Heme; Humans; Iron; | 1983 |
Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II).
Topics: 2,2'-Dipyridyl; Ammonium Chloride; Azides; Biological Transport; Cell Line; Chloroquine; Cytoplasm; | 1995 |
Enhanced susceptibility of cis-diamminedichloroplatinum-treated K562 cells to lysis by peripheral blood lymphocytes and lymphokine activated killer cells.
Topics: Aged; Aged, 80 and over; Antigens, Neoplasm; Antigens, Surface; Carboplatin; Chloroquine; Cisplatin; | 1993 |
Alterations in the internucleosomal DNA helical twist in chromatin of human erythroleukemia cells in vivo influences the chromatin higher-order folding.
Topics: Chloroquine; Chromatin; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Intercalating Agent | 1995 |
Calcium dependent cellular uptake of a c-myc antisense oligonucleotide.
Topics: Animals; Arsenicals; Base Sequence; Biological Transport; Calcium; Cell Line; Chloroquine; Deoxygluc | 1994 |
Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.
Topics: Antibodies, Monoclonal; Binding Sites, Antibody; Cell Line; Chloroquine; Endocytosis; Half-Life; Hum | 1986 |
Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells.
Topics: Ammonium Chloride; Animals; Cell Line; Cell Transformation, Neoplastic; Chloroquine; Endocytosis; Er | 1987 |