chloroquine has been researched along with Leishmaniasis in 22 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Leishmaniasis: A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The compounds were evaluated for their in vivo antimalarial activity against Plasmodium berghei infected mice and the most active derivatives were further examined for their in vitro antimalarial activity against chloroquine resistant (RKL9) strain of Plasmodium falciparum." | 7.81 | New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. ( Abd El Razik, HA; Bekhit, AA; Bekhit, Ael-D; El-Agroudy, EJ; El-Miligy, MM; Hassan, AM, 2015) |
| " The compounds were evaluated for their in vivo antimalarial activity against Plasmodium berghei infected mice and the most active derivatives were further examined for their in vitro antimalarial activity against chloroquine resistant (RKL9) strain of Plasmodium falciparum." | 3.81 | New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. ( Abd El Razik, HA; Bekhit, AA; Bekhit, Ael-D; El-Agroudy, EJ; El-Miligy, MM; Hassan, AM, 2015) |
| " In this study, a new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride (1), showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leishmaniasis model." | 3.77 | Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. ( Anklin, C; Bahar, M; Deng, Y; Doskotch, RW; Drew, ME; Gil, RR; He, S; Kinghorn, AD; Navarro-Vázquez, A; Pandharkar, T; Werbovetz, KA; Zhu, X, 2011) |
| "Cutaneous leishmaniasis is now considered a spectral and polar disease not unlike leprosy, caused by the leishmania parasite but also influenced by the host's immune response and intolerance." | 1.26 | [Cutaneous Leishmaniasis in Africa. Classification-clinical picture-treatment]. ( Stingl, P, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (77.27) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Patil, V | 1 |
| Guerrant, W | 1 |
| Chen, PC | 1 |
| Gryder, B | 1 |
| Benicewicz, DB | 1 |
| Khan, SI | 1 |
| Tekwani, BL | 1 |
| Oyelere, AK | 1 |
| Bahar, M | 1 |
| Deng, Y | 1 |
| Zhu, X | 1 |
| He, S | 1 |
| Pandharkar, T | 1 |
| Drew, ME | 1 |
| Navarro-Vázquez, A | 1 |
| Anklin, C | 1 |
| Gil, RR | 1 |
| Doskotch, RW | 1 |
| Werbovetz, KA | 1 |
| Kinghorn, AD | 1 |
| Herrera, L | 1 |
| Llanes, A | 1 |
| Álvarez, J | 1 |
| Degracia, K | 1 |
| Restrepo, CM | 1 |
| Rivera, R | 1 |
| Stephens, DE | 1 |
| Dang, HT | 1 |
| Larionov, OV | 1 |
| Lleonart, R | 1 |
| Fernández, PL | 1 |
| Bekhit, AA | 1 |
| Hassan, AM | 1 |
| Abd El Razik, HA | 1 |
| El-Miligy, MM | 1 |
| El-Agroudy, EJ | 1 |
| Bekhit, Ael-D | 1 |
| TELLA, A | 1 |
| INIAKHINA, AV | 1 |
| NEAL, RA | 1 |
| YOKOKAWA, K | 1 |
| Alexander, J | 1 |
| von Sonnenburg, F | 1 |
| Prüfer, L | 1 |
| Stingl, P | 1 |
| Fossati, C | 1 |
| Veras, PS | 1 |
| de Chastellier, C | 1 |
| Rabinovitch, M | 1 |
| Ramírez, O | 1 |
| Dedet, JP | 1 |
| Esterre, P | 1 |
| Várnai, F | 1 |
| Fülöp, E | 1 |
| Bánhegyi, D | 1 |
| Krampitz, HE | 1 |
| Schopp, W | 1 |
| Killig, H | 1 |
| Woodruff, AW | 2 |
| Bryceson, AD | 1 |
| Hart, M | 1 |
| Livingood, CS | 1 |
| Goltz, RW | 1 |
| Totonchy, M | 1 |
| Mansour, NS | 1 |
| McConnell, E | 1 |
3 reviews available for chloroquine and Leishmaniasis
| Article | Year |
|---|---|
[Progress in immunodiagnosis and chemotherapy of protozoan infections].
Topics: Amebiasis; Animals; Antibodies; Babesiosis; Chloroquine; Drug Resistance, Microbial; Giardiasis; Hum | 1983 |
[Treatment of intestinal parasitosis].
Topics: Amphotericin B; Anthelmintics; Bithionol; Cestode Infections; Chloroquine; Humans; Intestinal Diseas | 1975 |
Advances in the treatment of tropical diseases.
Topics: Acute Kidney Injury; Amebiasis; Antimalarials; Ascariasis; Chloroquine; Dexamethasone; Drug Resistan | 1968 |
19 other studies available for chloroquine and Leishmaniasis
| Article | Year |
|---|---|
Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.
Topics: Antimalarials; Antiprotozoal Agents; Histone Deacetylase Inhibitors; Histone Deacetylases; Leishmani | 2010 |
Potent antiprotozoal activity of a novel semi-synthetic berberine derivative.
Topics: Animals; Antiprotozoal Agents; Berberine; Chlorocebus aethiops; Disease Models, Animal; Inhibitory C | 2011 |
Antileishmanial activity of a new chloroquine analog in an animal model of Leishmania panamensis infection.
Topics: Animals; Antiprotozoal Agents; Chloroquine; Disease Models, Animal; Female; Leishmania; Leishmaniasi | 2020 |
New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents.
Topics: Animals; Antimalarials; Chemistry Techniques, Synthetic; Chloroquine; Drug Design; Drug Evaluation, | 2015 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
[EXPERIENCE WITH RESOCHIN (CHLOROQUINE) THERAPY OF BOROVSKI'I'S DISEASE].
Topics: Chloroquine; Leishmaniasis; Leishmaniasis, Mucocutaneous | 1964 |
CHEMOTHERAPY OF CUTANEOUS LEISHMANIASIS: LEISHMANIA TROPICA INFECTIONS IN MICE.
Topics: Amidines; Animals; Antimony; Antiprotozoal Agents; Chloroquine; Chlortetracycline; Dapsone; Deoxyrib | 1964 |
[AMERICAN LEISHMANIASIS, A CASE REPORT].
Topics: Antimony; Brazil; Chloroquine; Drug Therapy; Humans; Leishmaniasis; Leishmaniasis, Cutaneous; Leishm | 1965 |
Leishmania mexicana: inhibition and stimulation of phagosome-lysosome fusion in infected macrophages.
Topics: Animals; Cell Fusion; Cells, Cultured; Chloroquine; Female; Leishmania; Leishmaniasis; Lysosomes; Ma | 1981 |
[Cutaneous Leishmaniasis in Africa. Classification-clinical picture-treatment].
Topics: Africa; Chloroquine; Humans; Leishmaniasis; Male | 1982 |
Transfer of zymosan (yeast cell walls) to the parasitophorous vacuoles of macrophages infected with Leishmania amazonensis.
Topics: Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Cytochalasin D; Hydrogen-Ion Concentration | 1992 |
[Autochthonous cutaneous leishmaniasis in El Salvador. Report of 5 cases].
Topics: Adolescent; Adult; Agricultural Workers' Diseases; Animals; Antimony; Child; Chloroquine; El Salvado | 1986 |
Lack of effect of antimalarial prophylaxis with chloroquine or amodiaquine in cutaneous leishmaniasis in French Guiana.
Topics: Amodiaquine; Chloroquine; Humans; Leishmaniasis; Malaria | 1986 |
[Cases of cutaneous leishmaniasis imported by Hungarian citizens].
Topics: Administration, Topical; Chloroquine; Chlorpromazine; Humans; Hungary; Leishmaniasis; Travel; Tropic | 1985 |
[Diagnosis and epidemiology of Mediterranean cutaneous leishmaniasis].
Topics: Child, Preschool; Chloroquine; Disease Reservoirs; Diseases in Twins; Female; Humans; Leishmaniasis; | 1973 |
Current practice in tropical medicine.
Topics: Acute Kidney Injury; Amebiasis; Amebicides; Chloroquine; Cholera; Drug Resistance, Microbial; Hepati | 1969 |
Diffuse cutaneous leishmaniasis in Ethiopia. II. Treatment.
Topics: Adolescent; Amidines; Amphotericin B; Antimony; Antiprotozoal Agents; Child; Chloroquine; Female; Gl | 1970 |
Late cutaneous leishmaniasis.
Topics: Adult; Amphotericin B; Antimony; Biopsy; Chloroquine; Humans; Injections, Intradermal; Leishmania; L | 1969 |
Leishmaniasis in the Sudan Republic. 27. Lack of effect of chloroquine and pyrimethamine on visceral leishmaniasis in the hamster.
Topics: Animals; Chloroquine; Cricetinae; Leishmaniasis; Liver; Pyrimethamine; Sudan | 1966 |