chloroquine has been researched along with Kidney Neoplasms in 16 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Kidney Neoplasms: Tumors or cancers of the KIDNEY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Englerin A is a natural product with a very potent and selective cytotoxicity against renal cancer cells." | 5.38 | Englerin a selectively induces necrosis in human renal cancer cells. ( Chain, WJ; Fash, DM; Li, Z; Nakashige, ML; Ramos, JW; Sulzmaier, FJ, 2012) |
| "Ursolic acid activates autophagy in renal carcinoma 786-O cells, probably by inhibiting hedgehog signaling pathway activity." | 1.72 | Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism. ( Lyu, X; Sun, L; Wang, D; Wang, J; Zhang, X, 2022) |
| "The role of autophagy in nephroblastoma is largely uninvestigated." | 1.48 | Autophagy Inhibition in Childhood Nephroblastoma and the Therapeutic Significance. ( Chen, X; Gu, WZ; Li, LJ; Li, MJ; Lv, Y; Wang, JH; Wang, YL; Yang, M; Yuan, LQ; Zhao, ZY; Zhou, D; Zhu, K, 2018) |
| "Renal cell carcinoma is an aggressive disease often asymptomatic and weakly chemo-radiosensitive." | 1.42 | Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells. ( Boccellino, M; Caraglia, M; Desiderio, V; Di Lorenzo, G; Grimaldi, A; Lombardi, A; Misso, G; Pantano, F; Santini, D; Vitiello, PP; Zappavigna, S; Zoccoli, A, 2015) |
| "Englerin A is a natural product with a very potent and selective cytotoxicity against renal cancer cells." | 1.38 | Englerin a selectively induces necrosis in human renal cancer cells. ( Chain, WJ; Fash, DM; Li, Z; Nakashige, ML; Ramos, JW; Sulzmaier, FJ, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (75.00) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lyu, X | 1 |
| Zhang, X | 1 |
| Sun, L | 1 |
| Wang, J | 2 |
| Wang, D | 1 |
| Kovalenko, A | 1 |
| Sanin, A | 1 |
| Kosmas, K | 1 |
| Zhang, L | 1 |
| Akl, EW | 1 |
| Giannikou, K | 1 |
| Probst, CK | 1 |
| Hougard, TR | 1 |
| Rue, RW | 1 |
| Krymskaya, VP | 1 |
| Asara, JM | 1 |
| Lam, HC | 1 |
| Kwiatkowski, DJ | 1 |
| Henske, EP | 1 |
| Filippakis, H | 1 |
| Li, LJ | 1 |
| Wang, YL | 1 |
| Yuan, LQ | 1 |
| Gu, WZ | 1 |
| Zhu, K | 1 |
| Yang, M | 1 |
| Zhou, D | 1 |
| Lv, Y | 1 |
| Li, MJ | 1 |
| Zhao, ZY | 1 |
| Wang, JH | 1 |
| Chen, X | 1 |
| Singla, M | 1 |
| Bhattacharyya, S | 1 |
| Sun, J | 1 |
| Song, WD | 1 |
| Yan, SY | 1 |
| Xi, ZJ | 1 |
| Makhov, P | 1 |
| Golovine, K | 1 |
| Teper, E | 1 |
| Kutikov, A | 1 |
| Mehrazin, R | 1 |
| Corcoran, A | 1 |
| Tulin, A | 1 |
| Uzzo, RG | 1 |
| Kolenko, VM | 1 |
| Grimaldi, A | 1 |
| Santini, D | 1 |
| Zappavigna, S | 1 |
| Lombardi, A | 1 |
| Misso, G | 1 |
| Boccellino, M | 1 |
| Desiderio, V | 1 |
| Vitiello, PP | 1 |
| Di Lorenzo, G | 1 |
| Zoccoli, A | 1 |
| Pantano, F | 1 |
| Caraglia, M | 1 |
| Park, EJ | 1 |
| Min, KJ | 1 |
| Choi, KS | 1 |
| Kubatka, P | 1 |
| Kruzliak, P | 1 |
| Kim, DE | 1 |
| Kwon, TK | 1 |
| Kang, JH | 1 |
| Lee, JS | 1 |
| Hong, D | 1 |
| Lee, SH | 1 |
| Kim, N | 1 |
| Lee, WK | 1 |
| Sung, TW | 1 |
| Gong, YD | 1 |
| Kim, SY | 1 |
| Yin, P | 1 |
| Jia, J | 1 |
| Li, J | 1 |
| Song, Y | 1 |
| Zhang, Y | 1 |
| Chen, F | 1 |
| Zhou, L | 1 |
| Yang, H | 1 |
| Zhan, YH | 1 |
| Liu, J | 1 |
| Qu, XJ | 1 |
| Hou, KZ | 1 |
| Wang, KF | 1 |
| Liu, YP | 1 |
| Wu, B | 1 |
| Li, H | 1 |
| Jin, X | 1 |
| Zhang, Z | 1 |
| Xing, Y | 1 |
| Kong, X | 1 |
| Sulzmaier, FJ | 1 |
| Li, Z | 1 |
| Nakashige, ML | 1 |
| Fash, DM | 1 |
| Chain, WJ | 1 |
| Ramos, JW | 1 |
| Muhlbauer, JE | 1 |
| Pathak, MA | 1 |
| el-Mofty, MM | 1 |
| Khudoley, VV | 1 |
| Sakr, SA | 1 |
| Abdel-Gawad, HS | 1 |
1 review available for chloroquine and Kidney Neoplasms
| Article | Year |
|---|---|
Porphyria cutanea tarda.
Topics: Adolescent; Aged; Alcoholism; Animals; Chick Embryo; Child; Chloroquine; Diagnosis, Differential; He | 1979 |
15 other studies available for chloroquine and Kidney Neoplasms
| Article | Year |
|---|---|
Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism.
Topics: Apoptosis; Autophagy; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Chloroquine; Hedg | 2022 |
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
Topics: Angiolipoma; Animals; Autophagy; Cell Proliferation; Chloroquine; Diacylglycerol Kinase; Down-Regula | 2021 |
Autophagy Inhibition in Childhood Nephroblastoma and the Therapeutic Significance.
Topics: Animals; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Autopha | 2018 |
Autophagy as a potential therapeutic target during epithelial to mesenchymal transition in renal cell carcinoma: An in vitro study.
Topics: Autophagy; Carcinoma, Renal Cell; Cell Culture Techniques; Cell Line, Tumor; Chloroquine; Epithelial | 2017 |
[Chloroquine inhibits viability of renal carcinoma cells and enhances sunitinib-induced caspase-dependent apoptosis].
Topics: Animals; Antineoplastic Agents; Antirheumatic Agents; Apoptosis; Autophagy; Caspases; Cell Line, Tum | 2018 |
Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death.
Topics: Animals; Apoptosis; Autophagy; Breast Neoplasms; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proli | 2014 |
Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Ren | 2015 |
Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Chloroquine; Gene Expression Regulation, Neoplastic; Gene Knoc | 2016 |
Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Autophagy; Carcinoma, Renal Cell; Cell Line, Tumor; | 2016 |
ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosi | 2016 |
The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.
Topics: Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Carcinoma, Renal Cell; Cell Line, T | 2011 |
β-Elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways.
Topics: Adenine; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Chloroquine; Extracellul | 2012 |
Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells.
Topics: Adenine; Apoptosis; Autophagy; Carcinoma, Renal Cell; Cell Line, Tumor; Chloroquine; Drug Synergism; | 2013 |
Englerin a selectively induces necrosis in human renal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Calcium; Cell Line, Tumor; Cell Survival; Chloroquine; | 2012 |
The carcinogenicity of some antimalarial drugs using the Egyptian toad Bufo regularis as a biological test animal.
Topics: Animals; Antimalarials; Bufonidae; Chloroquine; Disease Models, Animal; Drug Combinations; Female; K | 1992 |