chloroquine has been researched along with Itching in 137 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Naltrexone exerted an antipruritic action, at least to a similar extent to promethazine in patients with chloroquine-induced itching in malaria fever." | 9.11 | Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching. ( Ajayi, AA; Kolawole, BA; Udoh, SJ, 2004) |
| "The significance of a pharmacokinetics basis in chloroquine (CQ)-induced pruritus was investigated by determining the disposition of the drug in two groups of volunteers; pruritus positive and pruritus negative." | 9.09 | Pharmacokinetic aspects of chloroquine-induced pruritus: influence of dose and evidence for varied extent of metabolism of the drug. ( Ogunbona, FA; Onyeji, CO, 2001) |
| "Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 9.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
| "1 g base total dose) with prednisolone caused a statistically significant reduction in the pruritus AUC (0, 72 h) (P < 0." | 9.08 | Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine. ( Adebayo, RA; Ajayi, AA; Onayemi, O; Sofowora, GG; Udoh, SJ, 1997) |
| "Chloroquine chemotherapy of malaria fever induces severe generalised pruritus in a large proportion of black Africans." | 9.07 | The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria. ( Ajayi, AA; Ajayi, OO; Akinleye, AO; Ijaware, CO; Oyelese, O; Udoh, SJ, 1991) |
| "The efficacy of chlorpheniramine in the prevention of choroquine-induced pruritus was assessed in a trial involving 132 malaria patients with a history of chloroquine-induced pruritus." | 9.07 | The efficacy of piriton on chloroquine-induced pruritus in patients with malaria. ( Mnyika, KS, 1991) |
| "The incidence and nature of pruritus induced by chloroquine and halofantrine were studied in 82 patients with acute malaria and in 40 healthy subjects, using a visual analogue scale for quantitating pruritus." | 9.07 | Halofantrine-induced pruritus amongst subjects who itch to chloroquine. ( Abila, B; Ambakederemo, AW; Ezeamuzie, IC; Igbigbi, PS; Nwaejike, IN, 1991) |
| "The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale." | 9.06 | Effects of clemastine, ketotifen and prednisolone on chloroquine-induced pruritus. ( Abila, B; Ikueze, R, 1989) |
| "The association of pruritus and ingestion of chloroquine phosphate in Saradidi, Kenya, was determined by randomly giving 437 children (less than 18 years) and 182 adults either 10 mg base kg-1 of regular chloroquine, 10 mg base kg-1 of enteric-coated chloroquine, 10 mg base kg-1 of amodiaquine, or one 300 mg tablet of enteric-coated ferrous sulphate." | 9.06 | Epidemiology of chloroquine-associated pruritus in Saradidi, Kenya. ( Brandling-Bennett, AD; Kaseje, DC; Oloo, AJ; Spencer, HC; Watkins, WM, 1987) |
| "Chloroquine (CQ) is an antimalarial drug that elicits severe pruritus in black Africans with malaria fever." | 9.01 | Itching, chloroquine, and malaria: a review of recent molecular and neuroscience advances and their contribution to mechanistic understanding and therapeutics of chronic non-histaminergic pruritus. ( Ajayi, AAL, 2019) |
| "The mechanisms whereby the intrinsic pruritogenic effect of chloroquine (a property also encountered among some other 4-amino-quinolines including amodiaquine) becomes aggravated during paroxysmal malarial suppressive chemotherapy with the drug form the basis of this paper." | 8.77 | Mechanisms of enhanced pruritogenicity of chloroquine among patients with malaria: a review. ( Osifo, NG, 1989) |
| " Pretreatment with perampanel dose-dependently attenuated the induction of scratching, a behavior typically associated with pruritus, by intradermal administration of the pruritogen chloroquine." | 7.96 | Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice. ( Funahashi, H; Haruta-Tsukamoto, A; Ishida, Y; Miyahara, Y; Nishimori, T, 2020) |
| "Chloroquine-induced pruritus has been described as a common adverse event in African patients being treated for Plasmodium falciparum malaria, and has been associated with treatment discontinuation in this setting." | 7.79 | Prevalence and risk factors associated to pruritus in Plasmodium vivax patients using chloroquine in the Brazilian Amazon. ( Alecrim, MG; Alexandre, MA; Ballut, PC; Lacerda, MV; Orlando, AC; Siqueira, AM, 2013) |
| " A major determinant of compliance with treatment in this environment is the pruritus chloroquine induces when ingested." | 7.72 | Pattern of chloroquine-induced pruritus in antenatal patients at the University College Hospital, Ibadan. ( Adeniji, AR; Aimakhu, CO; Fehintola, FA; Olayemi, O; Osungbade, A; Udoh, ES, 2003) |
| "The hypothesis that chloroquine-induced pruritus (CIP) may be determined by certain genetic factors was tested by investigating the epidemiology of CIP with respect to certain genetic red cell markers namely, haemoglobin genotype, glucose-6-phosphate dehydrogenase (G6PD) deficiency and the ABO blood groups." | 7.71 | Certain red cell genetic factors and prevalence of chloroquine-induced pruritus. ( Ademowo, OG; Sodeinde, O, 2002) |
| "The pharmacokinetics of chloroquine and its main metabolite desethylchloroquine have been carried out in volunteers with and without chloroquine-induced pruritus." | 7.70 | The disposition of chloroquine and its main metabolite desethylchloroquine in volunteers with and without chloroquine-induced pruritus: evidence for decreased chloroquine metabolism in volunteers with pruritus. ( Ademowo, OG; Sodeinde, O; Walker, O, 2000) |
| "Severe generalized pruritus is a common drawback in chloroquine therapy of malaria in black Africans." | 7.70 | Knowledge, attitude and practice of prednisolone prevention of chloroquine induced pruritus among Nigerian health workers. ( Ajayi, AA; Olotu, TC; Sofowora, GG, 1998) |
| "A clinical survey in Benin (Nigeria) has revealed that 393 out of 541 respondents experienced pruritus (itching) whenever they took chloroquine for malaria treatment." | 7.68 | Responsiveness of chloroquine-induced pruritus to antihistamine therapy--a clinical survey. ( Okor, RS, 1990) |
| "To confirm reports that chloroquine-induced pruritus might have a negative impact on chloroquine utilization on malaria control in Dar es Salaam, a precoded questionnaire was administered to 300 malaria patients and the respondents were then followed up at their homes during the period of their malaria treatment." | 7.68 | Chloroquine-induced pruritus: its impact on chloroquine utilization in malaria control in Dar es Salaam. ( Kihamia, CM; Mnyika, KS, 1991) |
| "A study of relations between pruritus after doses of chloroquine and on the one hand the infection by Mansonella perstans (filariasis frequent in some areas but pathogenic) and on the other hand the infection by Onchocerca volvulus (filariasis frequent in some other areas but not very pathogenic) was carried out in two villages in Ivory Coast." | 7.67 | [Pruritus after taking chloroquine and filariasis]. ( Coulibaly, A; Delolme, HG; Houdier, R; Rey, JL; Saki, Z; Soro, B; Yao, KF, 1989) |
| "Two hundred and fifty-one Nigerian medical and nursing students from the University of Maiduguri Teaching Hospital completed a questionnaire on chloroquine-induced pruritus." | 7.67 | Chloroquine-induced pruritus in Nigerian medical and nursing students. ( Chugh, KS; Harries, AD, 1986) |
| "A questionnaire survey was performed among 550 acutely febrile patients with malaria to determine whether pruritus accompanied chloroquine therapy when the drug was employed to suppress paroxysmal febrile attacks." | 7.67 | Chloroquine-induced pruritus among patients with malaria. ( Osifo, NG, 1984) |
| "Attention has once again been directed to the very uncomfortable itching following chloroquine chemotherapy of malaria in about 8% of the Nigeria population." | 7.65 | The practical and therapeutic implications of chloroquine-induced itching in tropical Africa. ( Olatunde, A, 1977) |
| "Chloroquine (CQ) is a prototypical systemic and intradermal pruritogen for histamine-independent (nonhistaminergic) itch in mice and humans." | 5.56 | Characterization of a chloroquine-induced canine model of pruritus and skin inflammation. ( Banovic, F; Blubaugh, A; Denley, T, 2020) |
| "Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 5.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
| "vivax malaria is low in comparison with black-skinned Africans." | 5.31 | Frequency of pruritus in Plasmodium vivax malaria patients treated with chloroquine in Thailand. ( Bussaratid, V; Krudsood, S; Looareesuwan, S; Silachamroon, U; Walsh, DS; Wilairatana, P, 2000) |
| "Bullous pemphigoid has been reported to be induced or precipitated by systemic therapy with several drugs, including penicillamine, captopril, frusemide and ampicillin." | 5.30 | Bullous pemphigoid developing during systemic therapy with chloroquine. ( Barker, JN; Black, MM; Millard, TP; Smith, HR, 1999) |
| " Significant alterations of pharmacokinetic parameters, a delayed completion of distribution with a biphasic pattern of uptake of chloroquine into peripheral organs (skin and skeletal musculature) and increased tissue uptake in visceral organs (heart, liver and kidneys) of pyrogen treated rats were found." | 5.26 | Chloroquine pharmacokinetics in tissues of pyrogen treated rats and implications for chloroquine related pruritus. ( Osifo, NG, 1980) |
| "Naltrexone exerted an antipruritic action, at least to a similar extent to promethazine in patients with chloroquine-induced itching in malaria fever." | 5.11 | Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching. ( Ajayi, AA; Kolawole, BA; Udoh, SJ, 2004) |
| "The significance of a pharmacokinetics basis in chloroquine (CQ)-induced pruritus was investigated by determining the disposition of the drug in two groups of volunteers; pruritus positive and pruritus negative." | 5.09 | Pharmacokinetic aspects of chloroquine-induced pruritus: influence of dose and evidence for varied extent of metabolism of the drug. ( Ogunbona, FA; Onyeji, CO, 2001) |
| "Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 5.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
| "1 g base total dose) with prednisolone caused a statistically significant reduction in the pruritus AUC (0, 72 h) (P < 0." | 5.08 | Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine. ( Adebayo, RA; Ajayi, AA; Onayemi, O; Sofowora, GG; Udoh, SJ, 1997) |
| "Chloroquine chemotherapy of malaria fever induces severe generalised pruritus in a large proportion of black Africans." | 5.07 | The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria. ( Ajayi, AA; Ajayi, OO; Akinleye, AO; Ijaware, CO; Oyelese, O; Udoh, SJ, 1991) |
| "5mg and histamine 2 micrograms in 11 healthy black subjects who experienced generalised pruritus with oral chloroquine." | 5.07 | Effects of two antihistamines on chloroquine and histamine induced weal and flare in healthy African volunteers. ( Abila, B; Ambakederemo, AW; Asomugha, L; Ezeamuzie, IC; Igbigbi, PS, 1994) |
| "The incidence and nature of pruritus induced by chloroquine and halofantrine were studied in 82 patients with acute malaria and in 40 healthy subjects, using a visual analogue scale for quantitating pruritus." | 5.07 | Halofantrine-induced pruritus amongst subjects who itch to chloroquine. ( Abila, B; Ambakederemo, AW; Ezeamuzie, IC; Igbigbi, PS; Nwaejike, IN, 1991) |
| "The efficacy of chlorpheniramine in the prevention of choroquine-induced pruritus was assessed in a trial involving 132 malaria patients with a history of chloroquine-induced pruritus." | 5.07 | The efficacy of piriton on chloroquine-induced pruritus in patients with malaria. ( Mnyika, KS, 1991) |
| "The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale." | 5.06 | Effects of clemastine, ketotifen and prednisolone on chloroquine-induced pruritus. ( Abila, B; Ikueze, R, 1989) |
| "The association of pruritus and ingestion of chloroquine phosphate in Saradidi, Kenya, was determined by randomly giving 437 children (less than 18 years) and 182 adults either 10 mg base kg-1 of regular chloroquine, 10 mg base kg-1 of enteric-coated chloroquine, 10 mg base kg-1 of amodiaquine, or one 300 mg tablet of enteric-coated ferrous sulphate." | 5.06 | Epidemiology of chloroquine-associated pruritus in Saradidi, Kenya. ( Brandling-Bennett, AD; Kaseje, DC; Oloo, AJ; Spencer, HC; Watkins, WM, 1987) |
| "Chloroquine (CQ) is an antimalarial drug that elicits severe pruritus in black Africans with malaria fever." | 5.01 | Itching, chloroquine, and malaria: a review of recent molecular and neuroscience advances and their contribution to mechanistic understanding and therapeutics of chronic non-histaminergic pruritus. ( Ajayi, AAL, 2019) |
| "The mechanisms whereby the intrinsic pruritogenic effect of chloroquine (a property also encountered among some other 4-amino-quinolines including amodiaquine) becomes aggravated during paroxysmal malarial suppressive chemotherapy with the drug form the basis of this paper." | 4.77 | Mechanisms of enhanced pruritogenicity of chloroquine among patients with malaria: a review. ( Osifo, NG, 1989) |
| " Pretreatment with perampanel dose-dependently attenuated the induction of scratching, a behavior typically associated with pruritus, by intradermal administration of the pruritogen chloroquine." | 3.96 | Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice. ( Funahashi, H; Haruta-Tsukamoto, A; Ishida, Y; Miyahara, Y; Nishimori, T, 2020) |
| " Itch responses were evoked by histamine, chloroquine, and dinitrochlorobenzene-induced contact dermatitis (CD)." | 3.88 | GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way. ( Han, MK; Im, SY; Im, YN; Kim, HK; Lee, HK; Lee, YD; Park, JS; Song, HR, 2018) |
| " An acetone-ether-water (AEW) model as a histamine-independent itch model is often used in the study of chronic pruritus." | 3.85 | MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model. ( Geng, X; Gu, L; Hu, D; Lan, L; Shi, H; Tang, Z; Wang, C; Wu, G; Yang, N; Yang, Y; Yu, G; Yu, L; Yuan, X; Zhu, C, 2017) |
| "Chloroquine-induced pruritus has been described as a common adverse event in African patients being treated for Plasmodium falciparum malaria, and has been associated with treatment discontinuation in this setting." | 3.79 | Prevalence and risk factors associated to pruritus in Plasmodium vivax patients using chloroquine in the Brazilian Amazon. ( Alecrim, MG; Alexandre, MA; Ballut, PC; Lacerda, MV; Orlando, AC; Siqueira, AM, 2013) |
| "Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain." | 3.79 | Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. ( Giesler, GJ; Moser, HR, 2013) |
| " Moreover, similar to wild-type littermates, Nf1± mice developed inflammation-induced heat and mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia." | 3.79 | Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. ( Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE, 2013) |
| "Chemotherapy of malaria fever with chloroquine is often associated with generalized pruritus of unknown pathogenesis." | 3.72 | Kappa opioid agonists suppress chloroquine-induced scratching in mice. ( Cowan, A; Inan, S, 2004) |
| " A major determinant of compliance with treatment in this environment is the pruritus chloroquine induces when ingested." | 3.72 | Pattern of chloroquine-induced pruritus in antenatal patients at the University College Hospital, Ibadan. ( Adeniji, AR; Aimakhu, CO; Fehintola, FA; Olayemi, O; Osungbade, A; Udoh, ES, 2003) |
| "The hypothesis that chloroquine-induced pruritus (CIP) may be determined by certain genetic factors was tested by investigating the epidemiology of CIP with respect to certain genetic red cell markers namely, haemoglobin genotype, glucose-6-phosphate dehydrogenase (G6PD) deficiency and the ABO blood groups." | 3.71 | Certain red cell genetic factors and prevalence of chloroquine-induced pruritus. ( Ademowo, OG; Sodeinde, O, 2002) |
| "Severe generalized pruritus is a common drawback in chloroquine therapy of malaria in black Africans." | 3.70 | Knowledge, attitude and practice of prednisolone prevention of chloroquine induced pruritus among Nigerian health workers. ( Ajayi, AA; Olotu, TC; Sofowora, GG, 1998) |
| "The pharmacokinetics of chloroquine and its main metabolite desethylchloroquine have been carried out in volunteers with and without chloroquine-induced pruritus." | 3.70 | The disposition of chloroquine and its main metabolite desethylchloroquine in volunteers with and without chloroquine-induced pruritus: evidence for decreased chloroquine metabolism in volunteers with pruritus. ( Ademowo, OG; Sodeinde, O; Walker, O, 2000) |
| "To confirm reports that chloroquine-induced pruritus might have a negative impact on chloroquine utilization on malaria control in Dar es Salaam, a precoded questionnaire was administered to 300 malaria patients and the respondents were then followed up at their homes during the period of their malaria treatment." | 3.68 | Chloroquine-induced pruritus: its impact on chloroquine utilization in malaria control in Dar es Salaam. ( Kihamia, CM; Mnyika, KS, 1991) |
| "The effectiveness of an antihistamine, chlorpheniramine, in suppressing chloroquine-related pruritus has been investigated in 38 patients, employing two modes of therapy." | 3.68 | Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy. ( Okor, RS, 1991) |
| "A clinical survey in Benin (Nigeria) has revealed that 393 out of 541 respondents experienced pruritus (itching) whenever they took chloroquine for malaria treatment." | 3.68 | Responsiveness of chloroquine-induced pruritus to antihistamine therapy--a clinical survey. ( Okor, RS, 1990) |
| "Using a presumptive animal model of the pruritus produced by chloroquine or amodiaquine in patients with malaria, the ability of mono de-ethylated chloroquine, chloroquine, mono de-ethylated amodiaquine, bi-de-ethylated amodiaquine and normal saline (placebo) to be differentiated in their pruritogenic potentials were determined." | 3.68 | Structure activity relationships in the pruritogenicity of chloroquine and amodiaquine metabolites in a dog model. ( Osifo, NG, 1991) |
| "Urine concentrations of methylhistamine were measured in 11 subjects who experienced itching with chloroquine ('itchers') and in 14 who did not itch ('non-itchers')." | 3.68 | Urine methylhistamine concentrations before and after chloroquine in healthy black subjects. ( Abila, B; Ambakederemo, AW; Asomugha, L; Assem, ES; Ezeamuzie, CI; Igbigbi, PS, 1990) |
| "A questionnaire survey was performed among 550 acutely febrile patients with malaria to determine whether pruritus accompanied chloroquine therapy when the drug was employed to suppress paroxysmal febrile attacks." | 3.67 | Chloroquine-induced pruritus among patients with malaria. ( Osifo, NG, 1984) |
| "A study of relations between pruritus after doses of chloroquine and on the one hand the infection by Mansonella perstans (filariasis frequent in some areas but pathogenic) and on the other hand the infection by Onchocerca volvulus (filariasis frequent in some other areas but not very pathogenic) was carried out in two villages in Ivory Coast." | 3.67 | [Pruritus after taking chloroquine and filariasis]. ( Coulibaly, A; Delolme, HG; Houdier, R; Rey, JL; Saki, Z; Soro, B; Yao, KF, 1989) |
| "Two hundred and fifty-one Nigerian medical and nursing students from the University of Maiduguri Teaching Hospital completed a questionnaire on chloroquine-induced pruritus." | 3.67 | Chloroquine-induced pruritus in Nigerian medical and nursing students. ( Chugh, KS; Harries, AD, 1986) |
| "Attention has once again been directed to the very uncomfortable itching following chloroquine chemotherapy of malaria in about 8% of the Nigeria population." | 3.65 | The practical and therapeutic implications of chloroquine-induced itching in tropical Africa. ( Olatunde, A, 1977) |
| " Surprisingly, oral dosing of both compounds suppressed scratching behaviors that were observed in mice." | 2.82 | Anti-pruritic effect of isothiocyanates: Potential involvement of toll-like receptor 3 signaling. ( Hayashi, I; Kainoh, M; Konno, M; Majima, Y; Moriyama, M; Serizawa, K; Suzuki, T; Yuzawa, N, 2022) |
| "Itching is a common side effect of epidermal growth factor receptor inhibitors." | 2.53 | Drug-Induced Itch Management. ( Ebata, T, 2016) |
| "Although itch and pain have many similarities, they are completely different in perceptual experience and behavioral response." | 1.91 | Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways. ( Li, BM; Liu, Y; Liu, YU; Ma, CL; Mou, B; Pan, H; Peng, J; Xiong, MT; Yang, Y; Yun, X; Zhang, JY; Zhang, QR; Zhao, HX, 2023) |
| "Atopic dermatitis is often associated with increased pain." | 1.91 | Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis. ( Akiyama, T; Bystrom, L; Ishida, H; Markan, A; Pavlenko, D; Todurga Seven, Z; Verpile, R, 2023) |
| "Itch (pruritus) is a common unpleasant feeling, often accompanied by the urge of scratching the skin." | 1.91 | Antipruritic effects of geraniol on acute and chronic itch via modulating spinal GABA/GRPR signaling. ( Chu, YX; Du, LX; Maoying, QL; Mi, WL; Qiao, Z; Wang, YQ; Yang, YC; Yang, YY; Yi, T; Zhu, JY, 2023) |
| "Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated." | 1.56 | Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons. ( Ase, AR; Ribeiro-da-Silva, A; Séguéla, P; Sharif, B, 2020) |
| "Chloroquine (CQ) is a prototypical systemic and intradermal pruritogen for histamine-independent (nonhistaminergic) itch in mice and humans." | 1.56 | Characterization of a chloroquine-induced canine model of pruritus and skin inflammation. ( Banovic, F; Blubaugh, A; Denley, T, 2020) |
| "This will promote the research and treatment of pruritus and depression." | 1.48 | The behavioral study on the interactive aggravation between pruritus and depression. ( Bai, Y; Feng, YP; Li, H; Wang, XD; Yang, G, 2018) |
| "Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment." | 1.48 | Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice. ( Bardoni, R; Barry, DM; Bruchas, MR; Chen, ZF; Huo, FQ; Jeffry, J; Jin, H; Kim, S; Li, H; Li, YQ; Liu, XY; Meng, QT; Mo, P; Munanairi, A; Peng, JH; Wan, L; Wu, ZY; Yang, Q; Yin, J; Yin, JB; Zhou, XY, 2018) |
| "Chloroquine was injected intradermally into the rostral back of NMRI mice, and the scratching behavior was evaluated by measuring the number of bouts over 30 min." | 1.48 | Pharmacological evidence of involvement of nitric oxide pathway in anti-pruritic effects of sumatriptan in chloroquine-induced scratching in mice. ( Afshari, K; Dehpour, AR; Foroutan, A; Haddadi, NS; Ostadhadi, S; Rahimi, N; Shakiba, S, 2018) |
| "Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 1.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
| "Chloroquine (CQ) is a widely used antimalarial drug that causes pruritus in humans and mice." | 1.42 | Characterization and Validation of a Canine Pruritic Model. ( Aberg, GA; Arulnesan, N; Bolger, GT; Ciofalo, VB; Pucaj, K, 2015) |
| "Imiquimod (IQ) is an agonist of Toll-like receptor 7 (TLR7) used to treat various infectious skin diseases such as genital warts, keratosis, and basal cell carcinoma." | 1.37 | Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons. ( Han, SK; Kim, D; Kim, SJ; Lee, CJ; Lee, J; Lee, SJ; Min, H; Park, GH; Simon, MI; Wall, E, 2011) |
| " Multiple chloroquine drug doses were used, revealing the existence of inverted-U dose-response relationships in every strain, allowing us to determine strain-dependent peak scratching behavior over the entire dose range." | 1.33 | Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse. ( Green, AD; Lehto, SG; Mogil, JS; Smith, SB; Young, KK, 2006) |
| "vivax malaria is low in comparison with black-skinned Africans." | 1.31 | Frequency of pruritus in Plasmodium vivax malaria patients treated with chloroquine in Thailand. ( Bussaratid, V; Krudsood, S; Looareesuwan, S; Silachamroon, U; Walsh, DS; Wilairatana, P, 2000) |
| "Bullous pemphigoid has been reported to be induced or precipitated by systemic therapy with several drugs, including penicillamine, captopril, frusemide and ampicillin." | 1.30 | Bullous pemphigoid developing during systemic therapy with chloroquine. ( Barker, JN; Black, MM; Millard, TP; Smith, HR, 1999) |
| "Treatment with prednisolone (15 mg/day), chloroquine phosphate (200 mg/ day), cyclosporine (5 mg/kg daily), and gold (10 mg/day) failed to reduce pruritic plaque formation, and pulse methylprednisolone therapy led to only a transient remission." | 1.29 | Widespread pruritic plaques in a patient with subacute cutaneous lupus erythematosus and hypocomplementemia: response to dapsone therapy. ( Hatta, N; Imai, T; Sakai, H; Takata, M; Takehara, K; Tsutsui, K, 1996) |
| " Over a 2-yr period we have prospectively reviewed 114 patients with a suspected adverse cutaneous reaction to anti-rheumatic drugs." | 1.29 | Suspected cutaneous drug toxicity in rheumatoid arthritis--an evaluation. ( Davis, MJ; Dawes, PT; Mattey, DL; Smith, AG; Wilkinson, SM, 1993) |
| " Significant alterations of pharmacokinetic parameters, a delayed completion of distribution with a biphasic pattern of uptake of chloroquine into peripheral organs (skin and skeletal musculature) and increased tissue uptake in visceral organs (heart, liver and kidneys) of pyrogen treated rats were found." | 1.26 | Chloroquine pharmacokinetics in tissues of pyrogen treated rats and implications for chloroquine related pruritus. ( Osifo, NG, 1980) |
| "1." | 1.25 | Chloroquine concentrations in the skin of rabbits and man. ( Olatunde, IA, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (14.60) | 18.7374 |
| 1990's | 20 (14.60) | 18.2507 |
| 2000's | 13 (9.49) | 29.6817 |
| 2010's | 57 (41.61) | 24.3611 |
| 2020's | 27 (19.71) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Q | 3 |
| Tang, Z | 3 |
| Surdenikova, L | 1 |
| Kim, S | 2 |
| Patel, KN | 3 |
| Kim, A | 1 |
| Ru, F | 2 |
| Guan, Y | 2 |
| Weng, HJ | 2 |
| Geng, Y | 1 |
| Undem, BJ | 2 |
| Kollarik, M | 1 |
| Chen, ZF | 2 |
| Anderson, DJ | 1 |
| Dong, X | 5 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 2 |
| Inan, S | 2 |
| Dun, NJ | 1 |
| Cowan, A | 2 |
| Zhang, Z | 1 |
| Pan, J | 1 |
| Zhu, T | 1 |
| Malewicz, N | 1 |
| Ye, K | 1 |
| Rong, J | 1 |
| Luo, Y | 1 |
| Situ, Y | 1 |
| Verkhratsky, A | 1 |
| Wang, Y | 1 |
| Zhao, J | 1 |
| Tang, D | 1 |
| Nie, H | 2 |
| Kim, H | 2 |
| Cho, H | 1 |
| Lee, B | 1 |
| Lu, HJ | 1 |
| Kim, K | 1 |
| Chung, S | 1 |
| Shim, WS | 2 |
| Shin, YK | 1 |
| Wood, JN | 1 |
| Oh, U | 1 |
| Ryu, K | 3 |
| Heo, Y | 3 |
| Lee, Y | 3 |
| Jeon, H | 3 |
| Namkung, W | 3 |
| Yu, H | 2 |
| Xiong, J | 2 |
| Ye, AY | 2 |
| Cranfill, SL | 2 |
| Cannonier, T | 2 |
| Gautam, M | 2 |
| Zhang, M | 2 |
| Bilal, R | 2 |
| Park, JE | 2 |
| Xue, Y | 2 |
| Polam, V | 2 |
| Vujovic, Z | 2 |
| Dai, D | 2 |
| Ong, W | 2 |
| Ip, J | 2 |
| Hsieh, A | 2 |
| Mimouni, N | 2 |
| Lozada, A | 2 |
| Sosale, M | 2 |
| Ahn, A | 2 |
| Ma, M | 2 |
| Ding, L | 2 |
| Arsuaga, J | 2 |
| Luo, W | 2 |
| Moriyama, M | 2 |
| Konno, M | 2 |
| Serizawa, K | 2 |
| Yuzawa, N | 2 |
| Majima, Y | 2 |
| Hayashi, I | 2 |
| Suzuki, T | 2 |
| Kainoh, M | 2 |
| Fricke, TC | 1 |
| Pantke, S | 1 |
| Lüttmann, B | 1 |
| Echtermeyer, FG | 1 |
| Herzog, C | 1 |
| Eberhardt, MJ | 1 |
| Leffler, A | 1 |
| Tian, W | 1 |
| He, D | 1 |
| Liu, J | 1 |
| Chen, F | 1 |
| Zhang, W | 1 |
| Hu, J | 2 |
| Wang, S | 1 |
| Yang, Y | 2 |
| Mou, B | 1 |
| Zhang, QR | 1 |
| Zhao, HX | 1 |
| Zhang, JY | 1 |
| Yun, X | 1 |
| Xiong, MT | 1 |
| Liu, Y | 1 |
| Liu, YU | 1 |
| Pan, H | 2 |
| Ma, CL | 1 |
| Li, BM | 1 |
| Peng, J | 1 |
| Funahashi, H | 5 |
| Pavlenko, D | 3 |
| Sakai, K | 4 |
| Verpile, R | 2 |
| Sanders, KM | 2 |
| Akiyama, T | 12 |
| Yang, YY | 1 |
| Du, LX | 1 |
| Zhu, JY | 1 |
| Yi, T | 1 |
| Yang, YC | 1 |
| Qiao, Z | 1 |
| Maoying, QL | 1 |
| Chu, YX | 1 |
| Wang, YQ | 1 |
| Mi, WL | 1 |
| Haruta-Tsukamoto, A | 3 |
| Kanemaru-Kawazoe, A | 1 |
| Kogoh, Y | 1 |
| Miyahara, Y | 3 |
| Hirano, Y | 1 |
| Nishimori, T | 3 |
| Ishida, Y | 3 |
| Todurga Seven, Z | 1 |
| Bystrom, L | 1 |
| Markan, A | 1 |
| Ishida, H | 1 |
| Chen, WZ | 1 |
| Shen, TY | 1 |
| Wang, M | 1 |
| Yuan, L | 1 |
| Wang, LH | 1 |
| Ding, WQ | 1 |
| Shi, XX | 1 |
| Wang, XF | 1 |
| Bo, BS | 1 |
| Liang, ZF | 1 |
| Sun, YG | 1 |
| Haddadi, NS | 5 |
| Shakiba, S | 2 |
| Afshari, K | 2 |
| Haj-Mirzaian, A | 1 |
| Vesaghati, S | 1 |
| Gharagozlou, S | 1 |
| Foroumadi, R | 1 |
| Shafaroodi, H | 1 |
| Ostadhadi, S | 5 |
| Dehpour, AR | 5 |
| Ganchingco, JRC | 1 |
| Fukuyama, T | 1 |
| Yoder, JA | 1 |
| Bäumer, W | 1 |
| Blubaugh, A | 1 |
| Denley, T | 1 |
| Banovic, F | 1 |
| Matsuo, T | 1 |
| Naono-Nakayama, R | 1 |
| Ebihara, K | 1 |
| Huang, Z | 1 |
| Zhou, X | 1 |
| Zhang, J | 1 |
| Mai, CL | 1 |
| Mai, JZ | 1 |
| Liu, C | 2 |
| Zhang, H | 1 |
| Liu, XG | 1 |
| Alvaro, CG | 1 |
| Braz, JM | 2 |
| Bernstein, M | 1 |
| Hamel, KA | 1 |
| Craik, V | 1 |
| Yamanaka, H | 1 |
| Basbaum, AI | 2 |
| Sharif, B | 1 |
| Ase, AR | 1 |
| Ribeiro-da-Silva, A | 1 |
| Séguéla, P | 1 |
| Ramachandran, R | 2 |
| Thompson, SK | 1 |
| Malkmus, S | 2 |
| Mieda, T | 1 |
| Lin, JH | 1 |
| Gupta, S | 1 |
| Yaksh, TL | 3 |
| Gadotti, VM | 2 |
| Kreitinger, JM | 1 |
| Wageling, NB | 1 |
| Budke, D | 1 |
| Diaz, P | 1 |
| Zamponi, GW | 2 |
| Hashimoto, T | 3 |
| Lozada, T | 1 |
| Yosipovitch, G | 2 |
| Samineni, VK | 2 |
| Grajales-Reyes, JG | 1 |
| Grajales-Reyes, GE | 1 |
| Tycksen, E | 1 |
| Copits, BA | 1 |
| Pedersen, C | 1 |
| Ankudey, ES | 1 |
| Sackey, JN | 1 |
| Sewell, SB | 1 |
| Bruchas, MR | 2 |
| Gereau, RW | 4 |
| Wercberger, R | 1 |
| Weinrich, JA | 1 |
| Miao, X | 1 |
| Huang, Y | 3 |
| Liu, TT | 2 |
| Guo, R | 1 |
| Wang, B | 1 |
| Wang, XL | 1 |
| Chen, LH | 2 |
| Zhou, Y | 2 |
| Ji, RR | 1 |
| Liu, T | 2 |
| Cao, LF | 1 |
| Si, M | 1 |
| Peng, XY | 1 |
| Qin, YQ | 1 |
| Luo, WF | 1 |
| Tarrasón, G | 1 |
| Carcasona, C | 1 |
| Eichhorn, P | 1 |
| Pérez, B | 1 |
| Gavaldà, A | 1 |
| Godessart, N | 1 |
| Elliott, P | 1 |
| G'Sell, M | 1 |
| Snyder, LM | 1 |
| Ross, SE | 1 |
| Ventura, V | 1 |
| Rahimi, N | 2 |
| Foroutan, A | 4 |
| Shi, H | 1 |
| Yu, G | 1 |
| Geng, X | 1 |
| Gu, L | 1 |
| Yang, N | 1 |
| Wang, C | 1 |
| Zhu, C | 1 |
| Yu, L | 1 |
| Hu, D | 1 |
| Yuan, X | 1 |
| Lan, L | 1 |
| Wu, G | 2 |
| Norouzi-Javidan, A | 1 |
| Momeny, M | 1 |
| Zarrinrad, G | 1 |
| Ghaffari, SH | 1 |
| Palkar, R | 1 |
| Ongun, S | 1 |
| Catich, E | 1 |
| Li, N | 1 |
| Borad, N | 1 |
| Sarkisian, A | 1 |
| McKemy, DD | 1 |
| Im, YN | 1 |
| Lee, YD | 1 |
| Park, JS | 1 |
| Kim, HK | 1 |
| Im, SY | 1 |
| Song, HR | 1 |
| Lee, HK | 1 |
| Han, MK | 1 |
| Marino, MJ | 1 |
| Paul, S | 1 |
| Wang, Z | 1 |
| Mascarenhas, NL | 1 |
| Pellett, S | 1 |
| Johnson, EA | 1 |
| DiNardo, A | 1 |
| Munanairi, A | 1 |
| Liu, XY | 1 |
| Barry, DM | 1 |
| Yang, Q | 1 |
| Yin, JB | 1 |
| Jin, H | 1 |
| Li, H | 2 |
| Meng, QT | 1 |
| Peng, JH | 1 |
| Wu, ZY | 1 |
| Yin, J | 1 |
| Zhou, XY | 1 |
| Wan, L | 1 |
| Mo, P | 1 |
| Huo, FQ | 1 |
| Jeffry, J | 1 |
| Li, YQ | 2 |
| Bardoni, R | 1 |
| Lipshetz, B | 1 |
| Khasabov, SG | 1 |
| Truong, H | 1 |
| Netoff, TI | 1 |
| Simone, DA | 1 |
| Giesler, GJ | 3 |
| Follansbee, T | 1 |
| Fujii, M | 1 |
| Davoodi, A | 3 |
| Nagamine, M | 3 |
| Iodi Carstens, M | 1 |
| Carstens, E | 6 |
| Wang, XD | 1 |
| Yang, G | 1 |
| Bai, Y | 2 |
| Feng, YP | 1 |
| Ajayi, AAL | 1 |
| Henry, TD | 1 |
| Fatima, M | 1 |
| Ren, X | 1 |
| Slade, HFE | 1 |
| Asmar, AJ | 1 |
| Xiong, CM | 1 |
| Shi, A | 1 |
| Xiong, AE | 1 |
| Wang, L | 1 |
| Duan, B | 1 |
| Chen, YB | 1 |
| Huang, J | 1 |
| Sun, Y | 1 |
| Li, JN | 1 |
| Yang, J | 1 |
| Su, XY | 1 |
| Chen, M | 1 |
| Yuan, Y | 1 |
| Li, Y | 2 |
| Guo, SS | 1 |
| Luo, HQ | 1 |
| Huang, C | 1 |
| Sun, W | 1 |
| Zhu, MX | 1 |
| Liu, MG | 1 |
| Xu, TL | 1 |
| Moser, HR | 1 |
| O'Brien, DE | 1 |
| Brenner, DS | 1 |
| Gutmann, DH | 1 |
| Mishra, SK | 1 |
| Ballut, PC | 1 |
| Siqueira, AM | 1 |
| Orlando, AC | 1 |
| Alexandre, MA | 1 |
| Alecrim, MG | 1 |
| Lacerda, MV | 1 |
| Xu, Y | 1 |
| Lopes, C | 1 |
| Wende, H | 1 |
| Guo, Z | 1 |
| Cheng, L | 1 |
| Birchmeier, C | 1 |
| Ma, Q | 1 |
| Tominaga, M | 6 |
| Takamori, K | 3 |
| Carstens, MI | 6 |
| Zhang, L | 1 |
| Jiang, GY | 1 |
| Song, NJ | 1 |
| Chen, JY | 1 |
| Wang, QX | 1 |
| Ding, YQ | 1 |
| Piecha, D | 1 |
| Steppan, S | 1 |
| Min, H | 2 |
| Lee, H | 1 |
| Lim, H | 1 |
| Jang, YH | 1 |
| Chung, SJ | 1 |
| Lee, CJ | 2 |
| Lee, SJ | 2 |
| Jansen, NA | 1 |
| Valtcheva, MV | 2 |
| Davidson, S | 2 |
| Zhao, C | 1 |
| Leitges, M | 1 |
| Golden, JP | 1 |
| Sistany, N | 1 |
| Pradhananga, S | 1 |
| Aberg, GA | 1 |
| Arulnesan, N | 1 |
| Bolger, GT | 1 |
| Ciofalo, VB | 1 |
| Pucaj, K | 1 |
| Morgenweck, J | 1 |
| Frankowski, KJ | 1 |
| Prisinzano, TE | 1 |
| Aubé, J | 1 |
| Bohn, LM | 1 |
| Kusube, F | 1 |
| Kawasaki, H | 1 |
| Yamakura, F | 1 |
| Naito, H | 1 |
| Ogawa, H | 1 |
| Tomooka, Y | 1 |
| Ebata, T | 1 |
| Lei, Z | 1 |
| Sami Shaikh, A | 1 |
| Zheng, W | 1 |
| Yu, X | 1 |
| Yu, J | 1 |
| Li, J | 1 |
| Azimi, E | 1 |
| Nateghpour, M | 1 |
| Lerner, EA | 1 |
| Sun, H | 1 |
| Jurcakova, D | 1 |
| Herbstsomer, RA | 1 |
| Meixong, J | 1 |
| Bandell, M | 1 |
| Patapoutian, A | 1 |
| Su, X | 1 |
| Kim, SJ | 1 |
| Park, GH | 1 |
| Kim, D | 1 |
| Lee, J | 1 |
| Wall, E | 1 |
| Simon, MI | 1 |
| Han, SK | 1 |
| Wilson, SR | 1 |
| Gerhold, KA | 1 |
| Bifolck-Fisher, A | 1 |
| Bautista, DM | 1 |
| Mir, A | 1 |
| Tlougan, B | 1 |
| O'Reilly, K | 1 |
| Tzu, J | 1 |
| Meehan, S | 1 |
| Kamino, H | 1 |
| Franks, AG | 1 |
| Han, N | 1 |
| Zu, JY | 1 |
| Chai, J | 1 |
| McCoy, ES | 1 |
| Taylor-Blake, B | 1 |
| Zylka, MJ | 1 |
| Carstens, EE | 1 |
| Yao, RS | 1 |
| Li, TT | 1 |
| Xu, J | 1 |
| Jiang, LE | 1 |
| Ruan, BF | 1 |
| Marino, M | 1 |
| Huang, P | 1 |
| Robertshaw, E | 1 |
| Mac, EA | 1 |
| Shatterman, Y | 1 |
| Blansit, K | 2 |
| Horwitz, A | 2 |
| Han, L | 1 |
| Ma, C | 1 |
| Cui, Y | 1 |
| Kim, Y | 1 |
| Qu, L | 1 |
| Li, Z | 1 |
| McNeil, B | 1 |
| He, S | 1 |
| Xiao, B | 1 |
| Lamotte, RH | 1 |
| Song, Y | 1 |
| Pan, X | 1 |
| Xiang, H | 1 |
| Olayemi, O | 1 |
| Fehintola, FA | 1 |
| Osungbade, A | 1 |
| Aimakhu, CO | 1 |
| Udoh, ES | 1 |
| Adeniji, AR | 1 |
| EKPECHI, OL | 1 |
| OKORO, AN | 1 |
| Ademowo, OG | 2 |
| Sodeinde, O | 2 |
| Ajayi, AA | 6 |
| Kolawole, BA | 1 |
| Udoh, SJ | 3 |
| Green, AD | 1 |
| Young, KK | 1 |
| Lehto, SG | 1 |
| Smith, SB | 1 |
| Mogil, JS | 1 |
| Wieczorek, D | 1 |
| Spencer, HC | 2 |
| Poulter, NR | 1 |
| Lury, JD | 1 |
| Poulter, CJ | 1 |
| Caussade, P | 1 |
| Bhasin, V | 1 |
| Goel, S | 1 |
| Srivastava, VK | 1 |
| Osifo, NG | 5 |
| Olatunde, A | 2 |
| Obih, PO | 1 |
| Mnyika, KS | 3 |
| Kabalimu, TK | 1 |
| Lugoe, WL | 1 |
| Abila, B | 4 |
| Ezeamuzie, IC | 2 |
| Igbigbi, PS | 3 |
| Ambakederemo, AW | 3 |
| Asomugha, L | 2 |
| Wilkinson, SM | 1 |
| Smith, AG | 1 |
| Davis, MJ | 1 |
| Mattey, DL | 1 |
| Dawes, PT | 1 |
| Mharakurwa, S | 1 |
| Mugochi, T | 1 |
| Tsutsui, K | 1 |
| Imai, T | 1 |
| Hatta, N | 1 |
| Sakai, H | 1 |
| Takata, M | 1 |
| Takehara, K | 1 |
| George, AO | 1 |
| Adebayo, RA | 1 |
| Sofowora, GG | 2 |
| Onayemi, O | 1 |
| Jiménez-Alonso, J | 1 |
| Tercedor, J | 1 |
| Jáimez, L | 1 |
| García-Lora, E | 1 |
| Olotu, TC | 1 |
| Millard, TP | 1 |
| Smith, HR | 1 |
| Black, MM | 1 |
| Barker, JN | 1 |
| Onigbogi, O | 1 |
| Ukponmwan, OE | 1 |
| Walker, O | 2 |
| Bussaratid, V | 1 |
| Walsh, DS | 1 |
| Wilairatana, P | 1 |
| Krudsood, S | 1 |
| Silachamroon, U | 1 |
| Looareesuwan, S | 1 |
| Onyeji, CO | 1 |
| Ogunbona, FA | 1 |
| Ebong, O | 1 |
| Okonkwo, PO | 1 |
| Ogunranti, JO | 1 |
| Aguiyi, JC | 1 |
| Roma, S | 1 |
| Onwukeme, KE | 1 |
| Okor, RS | 2 |
| Akinleye, AO | 1 |
| Ajayi, OO | 1 |
| Oyelese, O | 1 |
| Ijaware, CO | 1 |
| Kihamia, CM | 1 |
| Nwaejike, IN | 1 |
| Ezeamuzie, CI | 1 |
| Assem, ES | 1 |
| Soro, B | 1 |
| Rey, JL | 1 |
| Houdier, R | 1 |
| Coulibaly, A | 1 |
| Saki, Z | 1 |
| Yao, KF | 1 |
| Delolme, HG | 1 |
| Sowunmi, A | 1 |
| Salako, LA | 1 |
| Hallwood, PM | 1 |
| Horton, RJ | 1 |
| O'Sullivan, KM | 1 |
| Parr, SN | 1 |
| Ikueze, R | 1 |
| Guderian, RH | 1 |
| Williams, JF | 1 |
| Mackenzie, CD | 1 |
| Harries, AD | 1 |
| Chugh, KS | 1 |
| Kaseje, DC | 1 |
| Brandling-Bennett, AD | 1 |
| Oloo, AJ | 1 |
| Watkins, WM | 1 |
| Ashton, WL | 1 |
| Boardman, PL | 1 |
| D'Sa, CJ | 1 |
| Everall, PH | 1 |
| Houghton, AW | 1 |
| Meyer, W | 1 |
| Olatunde, IA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1, Randomized, Double-Blind, Vehicle-Controlled Ascending Doses Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ASN008 Topical Gel in Healthy Volunteers and Subjects With Atopic Dermatitis[NCT03798561] | Phase 1 | 24 participants (Actual) | Interventional | 2019-01-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for chloroquine and Itching
| Article | Year |
|---|---|
Anti-pruritic effect of isothiocyanates: Potential involvement of toll-like receptor 3 signaling.
Topics: Animals; Antipruritics; Chloroquine; Humans; Mice; Mice, Knockout; Pruritus; Skin; Toll-Like Recepto | 2022 |
Anti-pruritic effect of isothiocyanates: Potential involvement of toll-like receptor 3 signaling.
Topics: Animals; Antipruritics; Chloroquine; Humans; Mice; Mice, Knockout; Pruritus; Skin; Toll-Like Recepto | 2022 |
Anti-pruritic effect of isothiocyanates: Potential involvement of toll-like receptor 3 signaling.
Topics: Animals; Antipruritics; Chloroquine; Humans; Mice; Mice, Knockout; Pruritus; Skin; Toll-Like Recepto | 2022 |
Anti-pruritic effect of isothiocyanates: Potential involvement of toll-like receptor 3 signaling.
Topics: Animals; Antipruritics; Chloroquine; Humans; Mice; Mice, Knockout; Pruritus; Skin; Toll-Like Recepto | 2022 |
Itching, chloroquine, and malaria: a review of recent molecular and neuroscience advances and their contribution to mechanistic understanding and therapeutics of chronic non-histaminergic pruritus.
Topics: Action Potentials; Antimalarials; Antipruritics; Black People; Calcium; Chloroquine; Chronic Disease | 2019 |
Drug-Induced Itch Management.
Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Analgesics, Opioid; Antimalarials; Antineoplasti | 2016 |
Mechanisms of enhanced pruritogenicity of chloroquine among patients with malaria: a review.
Topics: Child, Preschool; Chloroquine; Drug Eruptions; Female; Humans; Infant; Malaria; Male; Pruritus; Skin | 1989 |
11 trials available for chloroquine and Itching
| Article | Year |
|---|---|
Endogenous opioids, mu-opiate receptors and chloroquine-induced pruritus: a double-blind comparison of naltrexone and promethazine in patients with malaria fever who have an established history of generalized chloroquine-induced itching.
Topics: Administration, Oral; Adult; Animals; Antimalarials; Antipruritics; Area Under Curve; Chloroquine; D | 2004 |
The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria.
Topics: Adolescent; Adult; Antimalarials; Antipruritics; Chloroquine; Chlorpheniramine; Cyproheptadine; Derm | 1995 |
Effects of two antihistamines on chloroquine and histamine induced weal and flare in healthy African volunteers.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Black People; Chloroquine; Clemastine | 1994 |
Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine.
Topics: Adult; Animals; Antimalarials; Area Under Curve; Chloroquine; Double-Blind Method; Drug Therapy, Com | 1997 |
Pharmacokinetic aspects of chloroquine-induced pruritus: influence of dose and evidence for varied extent of metabolism of the drug.
Topics: Adult; Antimalarials; Area Under Curve; Chloroquine; Humans; Male; Pruritus | 2001 |
The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria.
Topics: Adult; Chloroquine; Double-Blind Method; Female; Follow-Up Studies; Humans; Malaria, Falciparum; Mal | 1991 |
Halofantrine-induced pruritus amongst subjects who itch to chloroquine.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Chloroquine; Drug Eruptions; Drug Hypersensitivity; | 1991 |
The efficacy of piriton on chloroquine-induced pruritus in patients with malaria.
Topics: Chloroquine; Chlorpheniramine; Female; Humans; Malaria; Male; Pruritus | 1991 |
Pruritus and antimalarial drugs in Africans.
Topics: Antimalarials; Chloroquine; Humans; Nigeria; Phenanthrenes; Pruritus | 1989 |
Effects of clemastine, ketotifen and prednisolone on chloroquine-induced pruritus.
Topics: Adult; Analysis of Variance; Black People; Chloroquine; Clemastine; Humans; Ketotifen; Male; Prednis | 1989 |
Epidemiology of chloroquine-associated pruritus in Saradidi, Kenya.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Drug Eruptions; Humans; Kenya; Primary Health | 1987 |
122 other studies available for chloroquine and Itching
| Article | Year |
|---|---|
Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.
Topics: Animals; Capsaicin; Chloroquine; Ganglia, Spinal; Histamine; Humans; Mice; Pruritus; Receptors, G-Pr | 2009 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic.
Topics: Animals; Antipruritics; Behavior, Animal; Chloroquine; Deoxycholic Acid; Disease Models, Animal; Dos | 2021 |
Oxymatrine screened from Sophora flavescens by cell membrane immobilized chromatography relieves histamine-independent itch.
Topics: Alkaloids; Animals; Antipruritics; Cell Membrane; Chloroquine; Chromatography; Disease Models, Anima | 2021 |
Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor-dependent itch.
Topics: Animals; Anoctamin-1; Chloride Channels; Chloroquine; Ganglia, Spinal; GTP-Binding Proteins; Mice; P | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1.
Topics: Animals; Benzylisoquinolines; Chloroquine; Histamine; Mice; Pruritus; Ubiquitin-Protein Ligases | 2022 |
Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.
Topics: Animals; Behavior, Animal; Chloroquine; Deep Learning; Disease Models, Animal; Injections; Mice; Pru | 2022 |
Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.
Topics: Animals; Behavior, Animal; Chloroquine; Deep Learning; Disease Models, Animal; Injections; Mice; Pru | 2022 |
Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.
Topics: Animals; Behavior, Animal; Chloroquine; Deep Learning; Disease Models, Animal; Injections; Mice; Pru | 2022 |
Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.
Topics: Animals; Behavior, Animal; Chloroquine; Deep Learning; Disease Models, Animal; Injections; Mice; Pru | 2022 |
Molecular mechanisms of MrgprA3-independent activation of the transient receptor potential ion channels TRPA1 and TRPV1 by chloroquine.
Topics: Calcium; Chloroquine; Ganglia, Spinal; Humans; Pruritus; Reactive Oxygen Species; Sensory Receptor C | 2023 |
Topical borneol relieves nonhistaminergic pruritus via targeting TRPA1 and TRPM8 channels in peripheral nerve terminals of mice.
Topics: Animals; Antipruritics; Chloroquine; Mice; Peripheral Nerves; Pruritus; Sensory Receptor Cells; Tran | 2023 |
Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways.
Topics: Animals; Chloroquine; Histamine; Mice; Mice, Transgenic; Microglia; Pain; Pruritus; Signal Transduct | 2023 |
Dynorphinergic Projections from the Central Amygdala to the Parabrachial Nucleus Regulate Itch.
Topics: Animals; Central Amygdaloid Nucleus; Chloroquine; Mice; Neurons; Pain; Parabrachial Nucleus; Pruritu | 2023 |
Antipruritic effects of geraniol on acute and chronic itch via modulating spinal GABA/GRPR signaling.
Topics: Animals; Antipruritics; Bicuculline; Chloroquine; gamma-Aminobutyric Acid; Gastrin-Releasing Peptide | 2023 |
Role of kainate receptors in pruriceptive processing in the mouse spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chloroquine; Excitatory Amino Acid Antagonists; Gluta | 2023 |
Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis.
Topics: Animals; Calcium; Capsaicin; Chloroquine; Dermatitis, Atopic; Disease Models, Animal; Histamine; Neu | 2023 |
An atlas of itch-associated neural dynamics in the mouse brain.
Topics: Animals; Brain; Chloroquine; Histamine; Mice; Pruritus | 2023 |
Possible Involvement of Nitric Oxide in the Antipruritic Effect of Metformin on Chloroquine-Induced Scratching in Mice.
Topics: Animals; Antipruritics; Chloroquine; Dermatologic Agents; Enzyme Inhibitors; Injections; Metformin; | 2020 |
Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.
Topics: Animals; Cadaver; Calcium Radioisotopes; Capsaicin; Cattle; Cells, Cultured; Chloroquine; Dogs; Gang | 2019 |
Characterization of a chloroquine-induced canine model of pruritus and skin inflammation.
Topics: Administration, Intravenous; Animals; Chloroquine; Cross-Over Studies; Disease Models, Animal; Dogs; | 2020 |
Pharmacological characteristics of hemokinin-1-derived peptides in rat pruriceptive processing.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Chloroquine; Dose-Response Relationship, Drug | 2020 |
Bulleyaconitine A Inhibits Itch and Itch Sensitization Induced by Histamine and Chloroquine.
Topics: Aconitine; Animals; China; Chloroquine; Histamine; Mice; Posterior Horn Cells; Pruritus; Quality of | 2020 |
Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.
Topics: Animals; Behavior Rating Scale; Behavior, Animal; Chloroquine; Gene Knockout Techniques; Histamine; | 2020 |
Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons.
Topics: Adenosine Triphosphate; Animals; Channelrhodopsins; Chloroquine; Ganglia, Spinal; Gastrin-Releasing | 2020 |
Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus.
Topics: Administration, Topical; Animals; Antipruritics; Chloroquine; Dermatitis, Atopic; Disease Models, An | 2020 |
Cav3.2 T-type calcium channels control acute itch in mice.
Topics: Acute Disease; Animals; Behavior, Animal; Calcium Channels, T-Type; Chloroquine; Female; Histamine; | 2020 |
IL-23 modulates histamine-evoked itch and responses of pruriceptors in mice.
Topics: Animals; Behavior, Animal; Calcium; Cells, Cultured; Chloroquine; Ganglia, Spinal; Histamine; Interl | 2020 |
Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice.
Topics: Animals; Behavior, Animal; Chloroquine; Cyclopropanes; Disease Models, Animal; Histamine; Hypodermoc | 2020 |
Ethosuximide inhibits acute histamine- and chloroquine-induced scratching behavior in mice.
Topics: Animals; Behavior, Animal; Chloroquine; Ethosuximide; Female; Histamine; Male; Mice, Inbred C57BL; P | 2021 |
Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala.
Topics: Amygdala; Animals; Behavior, Animal; Chloroquine; Male; Mice; Mice, Inbred C57BL; Neurons; Pruritus; | 2021 |
Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons.
Topics: Animals; Chloroquine; Female; Gene Expression Regulation; Male; Mice, Inbred C57BL; Neurons; Pain; P | 2021 |
TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms.
Topics: Animals; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Etanercept; Ganglia, | 2018 |
Long-term anti-itch effect of botulinum neurotoxin A is associated with downregulation of TRPV1 and TRPA1 in the dorsal root ganglia in mice.
Topics: Acetone; Animals; Botulinum Toxins, Type A; Chloroquine; Chronic Disease; Disease Models, Animal; Do | 2017 |
Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.
Topics: Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricy | 2017 |
Automated acoustic detection of mouse scratching.
Topics: Acoustics; Algorithms; Animals; Automation; Chloroquine; Mice, Inbred C57BL; Models, Theoretical; Pr | 2017 |
Pharmacological evidence of involvement of nitric oxide pathway in anti-pruritic effects of sumatriptan in chloroquine-induced scratching in mice.
Topics: Animals; Antipruritics; Behavior, Animal; Chloroquine; Disease Models, Animal; Dose-Response Relatio | 2018 |
MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.
Topics: Acetone; Animals; Calcium; Cations, Divalent; Cells, Cultured; Chloroquine; Chronic Disease; Disease | 2017 |
Pharmacological evidence for the involvement of adenosine triphosphate sensitive potassium channels in chloroquine-induced itch in mice.
Topics: Animals; Antimalarials; Behavior, Animal; Chloroquine; Diazoxide; Glyburide; Injections, Intradermal | 2017 |
Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.
Topics: Animals; Antipruritics; Behavior, Animal; Capsaicin; Chloroquine; Chronic Disease; Cryotherapy; Dise | 2018 |
GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way.
Topics: Animals; Cell Line; Chloroquine; Dermatitis, Contact; Dinitrochlorobenzene; Disease Models, Animal; | 2018 |
A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus.
Topics: Animals; Botulinum Toxins, Type A; Cell Degranulation; Cells, Cultured; Chloroquine; Humans; Male; M | 2018 |
Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice.
Topics: Animals; Cell Membrane; Chloroquine; GTP-Binding Protein alpha Subunits, Gi-Go; HEK293 Cells; Humans | 2018 |
Responses of thalamic neurons to itch- and pain-producing stimuli in rats.
Topics: Action Potentials; Animals; Antipruritics; beta-Alanine; Capsaicin; Chloroquine; Histamine; Injectio | 2018 |
Effects of pruritogens and algogens on rostral ventromedial medullary ON and OFF cells.
Topics: Animals; Capsaicin; Chloroquine; Evoked Potentials; Hindlimb; Histamine; Male; Medulla Oblongata; Mi | 2018 |
The behavioral study on the interactive aggravation between pruritus and depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chloroquine; Depression; Depressive Disorder; Dise | 2018 |
A Subpopulation of Amygdala Neurons Mediates the Affective Component of Itch.
Topics: Amygdala; Animals; Avoidance Learning; Chloroquine; Female; Histamine; Male; Mice; Mice, Inbred C57B | 2019 |
Spinal somatostatin-positive interneurons transmit chemical itch.
Topics: Action Potentials; Angiogenesis Inhibitors; Animals; Chloroquine; Disease Models, Animal; In Vitro T | 2019 |
Serotoninergic projection from dorsal raphe nucleus to insular cortex is involved in acute itch sensation processing in mice.
Topics: Animals; Brain Stem; Cerebral Cortex; Chloroquine; Dorsal Raphe Nucleus; Histamine; Male; Mice; Mice | 2019 |
Central Processing of Itch in the Midbrain Reward Center.
Topics: Animals; Behavior, Animal; Calcium Signaling; Chloroquine; Dopaminergic Neurons; Electrophysiologica | 2019 |
Signal Transducer and Activator of Transcription 3 in Keratinocytes Regulates Histaminergic Itch but Not Nonhistaminergic Itch.
Topics: Animals; Chloroquine; Disease Models, Animal; Female; Histamine; Keratinocytes; Male; Mice, Knockout | 2019 |
Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
Topics: Action Potentials; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Electric Stimulat | 2013 |
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histam | 2013 |
The cells and circuitry for itch responses in mice.
Topics: Animals; Chloroquine; Endothelin-1; Gastrin-Releasing Peptide; Histamine; Male; Mice; Mice, Inbred C | 2013 |
Prevalence and risk factors associated to pruritus in Plasmodium vivax patients using chloroquine in the Brazilian Amazon.
Topics: Adolescent; Adult; Aged; Antimalarials; Brazil; Child; Child, Preschool; Chloroquine; Cross-Sectiona | 2013 |
Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities.
Topics: Animals; Animals, Newborn; Capsaicin; Cell Count; Chloroquine; Embryo, Mammalian; Ganglia, Spinal; G | 2013 |
Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antirheumatic Agents; Bombesin; Ch | 2014 |
Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord.
Topics: Animals; Butadienes; Chloroquine; Dinitrofluorobenzene; Disease Models, Animal; Enzyme Activation; E | 2014 |
Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice.
Topics: Animals; Antipruritics; Behavior, Animal; Chloroquine; Disease Models, Animal; Histamine; Ichthyosis | 2015 |
Role of spinal bombesin-responsive neurons in nonhistaminergic itch.
Topics: Animals; Bombesin; Capsaicin; Chloroquine; Histamine; Hot Temperature; Isothiocyanates; Male; Mice; | 2014 |
TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity.
Topics: Animals; Calcium; Capsaicin; Chloroquine; HEK293 Cells; Histamine; Humans; Intracellular Space; Ion | 2014 |
Response characteristics of pruriceptive and nociceptive trigeminoparabrachial tract neurons in the rat.
Topics: Action Potentials; Animals; beta-Alanine; Capsaicin; Cheek; Chloroquine; Histamine; Hot Temperature; | 2015 |
Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors.
Topics: Animals; beta-Alanine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Chloroq | 2015 |
Enhanced nonpeptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Cells, Cultured; Chloroquine; Disease Models, Ani | 2015 |
Chloroquine-induced scratching is mediated by NO/cGMP pathway in mice.
Topics: Animals; Behavior, Animal; Chloroquine; Cyclic GMP; Dose-Response Relationship, Drug; Male; Mice; Ni | 2015 |
Caffeic acid exhibits anti-pruritic effects by inhibition of multiple itch transmission pathways in mice.
Topics: Animals; Behavior, Animal; Caffeic Acids; Chloroquine; HEK293 Cells; Histamine; Humans; Menthol; Mic | 2015 |
Characterization and Validation of a Canine Pruritic Model.
Topics: Animals; Antimalarials; Antipruritics; Chloroquine; Cross-Over Studies; Dog Diseases; Dogs; Dose-Res | 2015 |
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2015 |
Electrophysiological properties of brain-natriuretic peptide- and gastrin-releasing peptide-responsive dorsal horn neurons in spinal itch transmission.
Topics: Action Potentials; Animals; Chloroquine; Gastrin-Releasing Peptide; Histamine; Male; Mice; Mice, Inb | 2016 |
Non-proton ligand-sensing domain of acid-sensing ion channel 3 is required for itch sensation.
Topics: Acid Sensing Ion Channels; Animals; Antimalarials; Cells, Cultured; Chloroquine; CHO Cells; Cricetin | 2016 |
Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice.
Topics: Animals; Behavior, Animal; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; En | 2017 |
Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin.
Topics: Action Potentials; Animals; Anoctamin-1; Chloroquine; Histamine; Male; Mice; Mice, Inbred C57BL; Neu | 2017 |
Itching for insight.
Topics: Animals; Antimalarials; Chloroquine; Humans; Pain; Pruritus; Sensory Receptor Cells; Skin | 2009 |
Antipruritic activity of extracts of Humulus scandens, the combinations of bioactive flavonoids.
Topics: 4-Aminopyridine; Animals; Antipruritics; Chloroquine; Dexamethasone; Flavonoids; Histamine; Humulus; | 2010 |
Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons.
Topics: Aminoquinolines; Animals; Chloroquine; Histamine; Imiquimod; Interferon Inducers; Mice; Neurons; Pru | 2011 |
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antirheumatic Agents; Calcium; Capsaicin; Cells, Cu | 2011 |
Morphea with discoid lupus erythematosus.
Topics: Antibodies, Bacterial; Arm; Atrophy; Borrelia burgdorferi; Chloroquine; Disease Progression; Doxycyc | 2011 |
Spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice.
Topics: Animals; Bombesin; Chloroquine; Denervation; Histamine; Histamine Agonists; Hypersensitivity; Immuno | 2012 |
CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Chloroquine; Female; Ga | 2012 |
Site-dependent and state-dependent inhibition of pruritogen-responsive spinal neurons by scratching.
Topics: Animals; Capsaicin; Chloroquine; Evoked Potentials; Histamine; Male; Mice; Mice, Inbred C57BL; Poste | 2012 |
Design, synthesis and anti-itch activity evaluation of aromatic amino acid derivatives as gastrin-releasing peptide receptor antagonists.
Topics: Amino Acids, Aromatic; Animals; Antipruritics; Binding Sites; Chloroquine; Computer Simulation; Drug | 2012 |
Development and validation of an automated system for detection and assessment of scratching in the rodent.
Topics: Algorithms; Analog-Digital Conversion; Animals; Anti-Allergic Agents; Automation; Behavior, Animal; | 2012 |
Cross-sensitization of histamine-independent itch in mouse primary sensory neurons.
Topics: Animals; Behavior, Animal; Calcium Signaling; Chloroquine; Ganglia, Spinal; Histamine; Male; Mice; M | 2012 |
Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors.
Topics: Animals; Calcium; Chloroquine; Ganglia, Spinal; Gastrin-Releasing Peptide; Histamine; Male; Mice; Mi | 2013 |
A subpopulation of nociceptors specifically linked to itch.
Topics: Action Potentials; Animals; Antirheumatic Agents; Calcium; Capsaicin; Cells, Cultured; Chloroquine; | 2013 |
Role of nociceptive arcuate nucleus neurons in chloroquine-induced pruritic behaviors in mice.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Chloroquine; Male; Mice; Mice, Inbred C57BL; Nociceptors; | 2012 |
Pattern of chloroquine-induced pruritus in antenatal patients at the University College Hospital, Ibadan.
Topics: Adult; Antimalarials; Chloroquine; Cross-Sectional Studies; Female; Humans; Malaria; Pregnancy; Preg | 2003 |
A PATTERN OF PRURITUS DUE TO CHLOROQUINE.
Topics: Black People; Chloroquine; Humans; Nigeria; Pruritus; Toxicology | 1964 |
Certain red cell genetic factors and prevalence of chloroquine-induced pruritus.
Topics: Adolescent; Adult; Antimalarials; Biomarkers; Child; Child, Preschool; Chloroquine; Erythrocytes; Fe | 2002 |
Kappa opioid agonists suppress chloroquine-induced scratching in mice.
Topics: Analgesics, Opioid; Animals; Chloroquine; Dose-Response Relationship, Drug; Male; Mice; Pruritus; Re | 2004 |
Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chloroquine; Dose-Response Relationship, Drug; Fema | 2006 |
[Treating chronic urticaria].
Topics: Adrenal Cortex Hormones; Adult; Child; Chloroquine; Chronic Disease; Cyclosporine; Dapsone; Diagnosi | 2006 |
Chloroquine-associated pruritus in a European.
Topics: Adult; Chloroquine; Drug Eruptions; Female; Humans; Kenya; Malaria; Pruritus; White People | 1982 |
[Pruritus induced by chloroquine during the treatment of malaria].
Topics: Chloroquine; Humans; Malaria; Pruritus | 1984 |
Role of pantothenic acid in chloroquine induced skin toxicity.
Topics: Adult; Antimalarials; Child, Preschool; Chloroquine; Female; Humans; Male; Pantothenic Acid; Pruritu | 1984 |
Chloroquine-induced pruritus among patients with malaria.
Topics: Adolescent; Adult; Black People; Child; Chloroquine; Female; Humans; Malaria; Male; Nigeria; Pruritu | 1984 |
Chloroquine pharmacokinetics in tissues of pyrogen treated rats and implications for chloroquine related pruritus.
Topics: Animals; Chloroquine; Escherichia coli; Half-Life; Kinetics; Male; Pruritus; Pyrogens; Rats; Tissue | 1980 |
Use and misuse of 4-aminoquinoline antimalarials in tropical Africa and re-examination of itch reaction to these drugs.
Topics: Amodiaquine; Chloroquine; Health Surveys; Humans; Malaria; Nigeria; Pruritus | 1981 |
Perception and utilisation of malaria prophylaxis among pregnant women in Dar es Salaam, Tanzania.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Cross-Sectional Studies; Female; Health Knowledge, At | 1995 |
Suspected cutaneous drug toxicity in rheumatoid arthritis--an evaluation.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, | 1993 |
Chloroquine-resistant falciparum malaria in an area of rising endemicity in Zimbabwe.
Topics: Absenteeism; Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Diseas | 1994 |
Widespread pruritic plaques in a patient with subacute cutaneous lupus erythematosus and hypocomplementemia: response to dapsone therapy.
Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chloroquine; Complement C3 | 1996 |
Chloroquine pruritus: a possible fixed cutaneous reaction.
Topics: Antimalarials; Chloroquine; Drug Eruptions; Female; Humans; Malaria; Male; Pruritus; Skin | 1996 |
Antimalarial drug-induced aquagenic-type pruritus in patients with lupus.
Topics: Adult; Antimalarials; Chloroquine; Data Collection; Female; Humans; Hydroxychloroquine; Lupus Erythe | 1998 |
Knowledge, attitude and practice of prednisolone prevention of chloroquine induced pruritus among Nigerian health workers.
Topics: Adult; Antimalarials; Antipruritics; Chloroquine; Cross-Sectional Studies; Female; Health Knowledge, | 1998 |
Bullous pemphigoid developing during systemic therapy with chloroquine.
Topics: Antirheumatic Agents; Biopsy; Chloroquine; Drug Eruptions; Dyspnea; Erythema Multiforme; Fluorescent | 1999 |
Mechanisms of chloroquine-induced body-scratching behavior in rats: evidence of involvement of endogenous opioid peptides.
Topics: Animals; Antimalarials; Chloroquine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Op | 2000 |
The disposition of chloroquine and its main metabolite desethylchloroquine in volunteers with and without chloroquine-induced pruritus: evidence for decreased chloroquine metabolism in volunteers with pruritus.
Topics: Adult; Antimalarials; Area Under Curve; Chloroquine; Chromatography, High Pressure Liquid; Humans; M | 2000 |
Mechanisms of chloroquine-induced pruritus.
Topics: Animals; Chloroquine; Humans; Malaria; Mice; Pruritus; Rats | 2000 |
Frequency of pruritus in Plasmodium vivax malaria patients treated with chloroquine in Thailand.
Topics: Adolescent; Adult; Animals; Antimalarials; Asian People; Child; Chloroquine; Drug Eruptions; Female; | 2000 |
The practical and therapeutic implications of chloroquine-induced itching in tropical Africa.
Topics: Adult; Child; Chloroquine; Female; Humans; Malaria; Male; Pruritus | 1977 |
Chloroquine induced pruritus-immunoglobulin level [proceedings].
Topics: Chloroquine; Humans; Immunoglobulins; Pruritus | 1976 |
Chloroquine-induced pruritus and sickle cell gene trait in Africans: possible pharmacogenetic relationship.
Topics: Adult; Chloroquine; Female; Humans; Male; Middle Aged; Pain Measurement; Pruritus; Sickle Cell Trait | 1992 |
Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy.
Topics: Adult; Chloroquine; Chlorpheniramine; Humans; Pruritus | 1991 |
Chloroquine-induced pruritus: its impact on chloroquine utilization in malaria control in Dar es Salaam.
Topics: Chloroquine; Drug Eruptions; Humans; Malaria; Pruritus; Surveys and Questionnaires; Tanzania | 1991 |
Responsiveness of chloroquine-induced pruritus to antihistamine therapy--a clinical survey.
Topics: Adult; Chloroquine; Histamine H1 Antagonists; Humans; Middle Aged; Pruritus | 1990 |
Structure activity relationships in the pruritogenicity of chloroquine and amodiaquine metabolites in a dog model.
Topics: Amodiaquine; Animals; Chloroquine; Dealkylation; Dogs; Female; Hindlimb; Ischemia; Male; Pruritus; S | 1991 |
Urine methylhistamine concentrations before and after chloroquine in healthy black subjects.
Topics: Adult; Analysis of Variance; Black People; Chloroquine; Female; Humans; Male; Methylhistamines; Prur | 1990 |
[Pruritus after taking chloroquine and filariasis].
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Cote d'Ivoire; Female; Filariasis; Humans; | 1989 |
Halofantrine and pruritus.
Topics: Child; Child, Preschool; Chloroquine; Drug Eruptions; Humans; Nigeria; Phenanthrenes; Pruritus; Time | 1989 |
Chloroquine and onchocerciasis.
Topics: Chloroquine; Ecuador; Female; Humans; In Vitro Techniques; Microfilariae; Onchocerca; Onchocerciasis | 1986 |
Chloroquine-induced pruritus in Nigerian medical and nursing students.
Topics: Administration, Oral; Adult; Chloroquine; Female; Histamine H1 Antagonists; Humans; Injections, Intr | 1986 |
Human fascioliasis in Shropshire.
Topics: Administration, Oral; Adolescent; Adult; Animals; Anthelmintics; Body Temperature; Chloroquine; Comp | 1970 |
[Clinical picture of rheumatic diseases. Current position of gold therapy].
Topics: Adrenal Glands; Antibody Formation; Arthritis, Rheumatoid; Chloroquine; Drug Eruptions; Drug Evaluat | 1974 |
Chloroquine concentrations in the skin of rabbits and man.
Topics: Adolescent; Adult; Animals; Chloroquine; Female; Fluorometry; Humans; Injections, Intravenous; Liver | 1971 |